data_5LLP
# 
_entry.id   5LLP 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   5LLP         pdb_00005llp 10.2210/pdb5llp/pdb 
WWPDB D_1200000962 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2017-08-16 
2 'Structure model' 1 1 2017-11-22 
3 'Structure model' 1 2 2017-11-29 
4 'Structure model' 1 3 2018-05-16 
5 'Structure model' 1 4 2024-01-10 
6 'Structure model' 1 5 2024-11-06 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1  2 'Structure model' 'Database references'    
2  2 'Structure model' 'Structure summary'      
3  3 'Structure model' 'Database references'    
4  4 'Structure model' 'Data collection'        
5  4 'Structure model' 'Database references'    
6  5 'Structure model' 'Data collection'        
7  5 'Structure model' 'Database references'    
8  5 'Structure model' 'Derived calculations'   
9  5 'Structure model' 'Refinement description' 
10 6 'Structure model' 'Structure summary'      
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1  2 'Structure model' citation                      
2  2 'Structure model' struct                        
3  3 'Structure model' pdbx_database_related         
4  4 'Structure model' citation                      
5  4 'Structure model' citation_author               
6  5 'Structure model' chem_comp_atom                
7  5 'Structure model' chem_comp_bond                
8  5 'Structure model' database_2                    
9  5 'Structure model' diffrn_radiation_wavelength   
10 5 'Structure model' pdbx_initial_refinement_model 
11 5 'Structure model' struct_conn                   
12 6 'Structure model' pdbx_entry_details            
13 6 'Structure model' pdbx_modification_feature     
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.title'                      
2  2 'Structure model' '_struct.title'                        
3  4 'Structure model' '_citation.country'                    
4  4 'Structure model' '_citation.journal_abbrev'             
5  4 'Structure model' '_citation.journal_id_CSD'             
6  4 'Structure model' '_citation.journal_id_ISSN'            
7  4 'Structure model' '_citation.journal_volume'             
8  4 'Structure model' '_citation.page_first'                 
9  4 'Structure model' '_citation.page_last'                  
10 4 'Structure model' '_citation.pdbx_database_id_DOI'       
11 4 'Structure model' '_citation.pdbx_database_id_PubMed'    
12 4 'Structure model' '_citation.title'                      
13 4 'Structure model' '_citation.year'                       
14 4 'Structure model' '_citation_author.name'                
15 5 'Structure model' '_database_2.pdbx_DOI'                 
16 5 'Structure model' '_database_2.pdbx_database_accession'  
17 5 'Structure model' '_struct_conn.pdbx_dist_value'         
18 5 'Structure model' '_struct_conn.pdbx_ptnr2_label_alt_id' 
19 5 'Structure model' '_struct_conn.ptnr1_auth_asym_id'      
20 5 'Structure model' '_struct_conn.ptnr1_auth_comp_id'      
21 5 'Structure model' '_struct_conn.ptnr1_auth_seq_id'       
22 5 'Structure model' '_struct_conn.ptnr1_label_asym_id'     
23 5 'Structure model' '_struct_conn.ptnr1_label_atom_id'     
24 5 'Structure model' '_struct_conn.ptnr1_label_comp_id'     
25 5 'Structure model' '_struct_conn.ptnr1_label_seq_id'      
26 5 'Structure model' '_struct_conn.ptnr2_auth_asym_id'      
27 5 'Structure model' '_struct_conn.ptnr2_auth_comp_id'      
28 5 'Structure model' '_struct_conn.ptnr2_auth_seq_id'       
29 5 'Structure model' '_struct_conn.ptnr2_label_asym_id'     
30 5 'Structure model' '_struct_conn.ptnr2_label_atom_id'     
31 5 'Structure model' '_struct_conn.ptnr2_label_comp_id'     
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        5LLP 
_pdbx_database_status.recvd_initial_deposition_date   2016-07-28 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.status_code_nmr_data            ? 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB . 5LLC unspecified 
PDB . 5LLE unspecified 
PDB . 5LLG unspecified 
PDB . 5LLH unspecified 
PDB . 5LLN unspecified 
PDB . 5LLO unspecified 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Smirnov, A.'  1 ? 
'Manakova, E.' 2 ? 
'Grazulis, S.' 3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            PeerJ 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2167-8359 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            6 
_citation.language                  ? 
_citation.page_first                e4412 
_citation.page_last                 e4412 
_citation.title                     
'Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding.' 
_citation.year                      2018 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.7717/peerj.4412 
_citation.pdbx_database_id_PubMed   29503769 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Smirnov, A.'  1 ? 
primary 'Zubriene, A.' 2 ? 
primary 'Manakova, E.' 3 ? 
primary 'Grazulis, S.' 4 ? 
primary 'Matulis, D.'  5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Carbonic anhydrase 12'                                                                                         
29917.318 4    4.2.1.1 ? 'human carbonic anhydrase XII' ? 
2 non-polymer syn 'ZINC ION'                                                                                                      
65.409    4    ?       ? 
'3-[(1S)-1,2,3,4-Tetrahydronapthalen-1-ylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide' ? 
3 non-polymer syn '3-[(1S)-1,2,3,4-Tetrahydronapthalen-1-ylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide' 
464.479   4    ?       ? Zn ? 
4 water       nat water                                                                                                           
18.015    1184 ?       ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Carbonate dehydratase XII,Carbonic anhydrase XII,CA-XII,Tumor antigen HOM-RCC-3.1.3' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQG
LQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFS
HLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPR
EMINNFRQVQKFDERLVYTSFSQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQG
LQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFS
HLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPR
EMINNFRQVQKFDERLVYTSFSQ
;
_entity_poly.pdbx_strand_id                 A,B,C,D 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                                                                                      ZN  
3 '3-[(1S)-1,2,3,4-Tetrahydronapthalen-1-ylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide' 6Z9 
4 water                                                                                                           HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   SER n 
1 3   LYS n 
1 4   TRP n 
1 5   THR n 
1 6   TYR n 
1 7   PHE n 
1 8   GLY n 
1 9   PRO n 
1 10  ASP n 
1 11  GLY n 
1 12  GLU n 
1 13  ASN n 
1 14  SER n 
1 15  TRP n 
1 16  SER n 
1 17  LYS n 
1 18  LYS n 
1 19  TYR n 
1 20  PRO n 
1 21  SER n 
1 22  CYS n 
1 23  GLY n 
1 24  GLY n 
1 25  LEU n 
1 26  LEU n 
1 27  GLN n 
1 28  SER n 
1 29  PRO n 
1 30  ILE n 
1 31  ASP n 
1 32  LEU n 
1 33  HIS n 
1 34  SER n 
1 35  ASP n 
1 36  ILE n 
1 37  LEU n 
1 38  GLN n 
1 39  TYR n 
1 40  ASP n 
1 41  ALA n 
1 42  SER n 
1 43  LEU n 
1 44  THR n 
1 45  PRO n 
1 46  LEU n 
1 47  GLU n 
1 48  PHE n 
1 49  GLN n 
1 50  GLY n 
1 51  TYR n 
1 52  ASN n 
1 53  LEU n 
1 54  SER n 
1 55  ALA n 
1 56  ASN n 
1 57  LYS n 
1 58  GLN n 
1 59  PHE n 
1 60  LEU n 
1 61  LEU n 
1 62  THR n 
1 63  ASN n 
1 64  ASN n 
1 65  GLY n 
1 66  HIS n 
1 67  SER n 
1 68  VAL n 
1 69  LYS n 
1 70  LEU n 
1 71  ASN n 
1 72  LEU n 
1 73  PRO n 
1 74  SER n 
1 75  ASP n 
1 76  MET n 
1 77  HIS n 
1 78  ILE n 
1 79  GLN n 
1 80  GLY n 
1 81  LEU n 
1 82  GLN n 
1 83  SER n 
1 84  ARG n 
1 85  TYR n 
1 86  SER n 
1 87  ALA n 
1 88  THR n 
1 89  GLN n 
1 90  LEU n 
1 91  HIS n 
1 92  LEU n 
1 93  HIS n 
1 94  TRP n 
1 95  GLY n 
1 96  ASN n 
1 97  PRO n 
1 98  ASN n 
1 99  ASP n 
1 100 PRO n 
1 101 HIS n 
1 102 GLY n 
1 103 SER n 
1 104 GLU n 
1 105 HIS n 
1 106 THR n 
1 107 VAL n 
1 108 SER n 
1 109 GLY n 
1 110 GLN n 
1 111 HIS n 
1 112 PHE n 
1 113 ALA n 
1 114 ALA n 
1 115 GLU n 
1 116 LEU n 
1 117 HIS n 
1 118 ILE n 
1 119 VAL n 
1 120 HIS n 
1 121 TYR n 
1 122 ASN n 
1 123 SER n 
1 124 ASP n 
1 125 LEU n 
1 126 TYR n 
1 127 PRO n 
1 128 ASP n 
1 129 ALA n 
1 130 SER n 
1 131 THR n 
1 132 ALA n 
1 133 SER n 
1 134 ASN n 
1 135 LYS n 
1 136 SER n 
1 137 GLU n 
1 138 GLY n 
1 139 LEU n 
1 140 ALA n 
1 141 VAL n 
1 142 LEU n 
1 143 ALA n 
1 144 VAL n 
1 145 LEU n 
1 146 ILE n 
1 147 GLU n 
1 148 MET n 
1 149 GLY n 
1 150 SER n 
1 151 PHE n 
1 152 ASN n 
1 153 PRO n 
1 154 SER n 
1 155 TYR n 
1 156 ASP n 
1 157 LYS n 
1 158 ILE n 
1 159 PHE n 
1 160 SER n 
1 161 HIS n 
1 162 LEU n 
1 163 GLN n 
1 164 HIS n 
1 165 VAL n 
1 166 LYS n 
1 167 TYR n 
1 168 LYS n 
1 169 GLY n 
1 170 GLN n 
1 171 GLU n 
1 172 ALA n 
1 173 PHE n 
1 174 VAL n 
1 175 PRO n 
1 176 GLY n 
1 177 PHE n 
1 178 ASN n 
1 179 ILE n 
1 180 GLU n 
1 181 GLU n 
1 182 LEU n 
1 183 LEU n 
1 184 PRO n 
1 185 GLU n 
1 186 ARG n 
1 187 THR n 
1 188 ALA n 
1 189 GLU n 
1 190 TYR n 
1 191 TYR n 
1 192 ARG n 
1 193 TYR n 
1 194 ARG n 
1 195 GLY n 
1 196 SER n 
1 197 LEU n 
1 198 THR n 
1 199 THR n 
1 200 PRO n 
1 201 PRO n 
1 202 CYS n 
1 203 ASN n 
1 204 PRO n 
1 205 THR n 
1 206 VAL n 
1 207 LEU n 
1 208 TRP n 
1 209 THR n 
1 210 VAL n 
1 211 PHE n 
1 212 ARG n 
1 213 ASN n 
1 214 PRO n 
1 215 VAL n 
1 216 GLN n 
1 217 ILE n 
1 218 SER n 
1 219 GLN n 
1 220 GLU n 
1 221 GLN n 
1 222 LEU n 
1 223 LEU n 
1 224 ALA n 
1 225 LEU n 
1 226 GLU n 
1 227 THR n 
1 228 ALA n 
1 229 LEU n 
1 230 TYR n 
1 231 CYS n 
1 232 THR n 
1 233 HIS n 
1 234 MET n 
1 235 ASP n 
1 236 ASP n 
1 237 PRO n 
1 238 SER n 
1 239 PRO n 
1 240 ARG n 
1 241 GLU n 
1 242 MET n 
1 243 ILE n 
1 244 ASN n 
1 245 ASN n 
1 246 PHE n 
1 247 ARG n 
1 248 GLN n 
1 249 VAL n 
1 250 GLN n 
1 251 LYS n 
1 252 PHE n 
1 253 ASP n 
1 254 GLU n 
1 255 ARG n 
1 256 LEU n 
1 257 VAL n 
1 258 TYR n 
1 259 THR n 
1 260 SER n 
1 261 PHE n 
1 262 SER n 
1 263 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   263 
_entity_src_gen.gene_src_common_name               Human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 CA12 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               'BL21(DE3)' 
_entity_src_gen.pdbx_host_org_variant              rosetta 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pET21a 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
6Z9 non-polymer         . 
'3-[(1S)-1,2,3,4-Tetrahydronapthalen-1-ylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide' ? 
'C18 H19 F3 N2 O5 S2' 464.479 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'          89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'      175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'         132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'          133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'        121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'        146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'          147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'          75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'      156.162 
HOH non-polymer         . WATER ? 'H2 O'                18.015  
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'         131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'         131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'      147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'       149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'         165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'          115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'          105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'          119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'       204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'         181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'         117.146 
ZN  non-polymer         . 'ZINC ION' ? 'Zn 2'                65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   SER 2   2   ?   ?   ?   A . n 
A 1 3   LYS 3   3   3   LYS LYS A . n 
A 1 4   TRP 4   4   4   TRP TRP A . n 
A 1 5   THR 5   5   5   THR THR A . n 
A 1 6   TYR 6   6   6   TYR TYR A . n 
A 1 7   PHE 7   7   7   PHE PHE A . n 
A 1 8   GLY 8   8   8   GLY GLY A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  ASP 10  10  10  ASP ASP A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  GLU 12  12  12  GLU GLU A . n 
A 1 13  ASN 13  13  13  ASN ASN A . n 
A 1 14  SER 14  14  14  SER SER A . n 
A 1 15  TRP 15  15  15  TRP TRP A . n 
A 1 16  SER 16  16  16  SER SER A . n 
A 1 17  LYS 17  17  17  LYS LYS A . n 
A 1 18  LYS 18  18  18  LYS LYS A . n 
A 1 19  TYR 19  19  19  TYR TYR A . n 
A 1 20  PRO 20  20  20  PRO PRO A . n 
A 1 21  SER 21  21  21  SER SER A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  GLY 24  24  24  GLY GLY A . n 
A 1 25  LEU 25  25  25  LEU LEU A . n 
A 1 26  LEU 26  26  26  LEU LEU A . n 
A 1 27  GLN 27  27  27  GLN GLN A . n 
A 1 28  SER 28  28  28  SER SER A . n 
A 1 29  PRO 29  29  29  PRO PRO A . n 
A 1 30  ILE 30  30  30  ILE ILE A . n 
A 1 31  ASP 31  31  31  ASP ASP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  HIS 33  33  33  HIS HIS A . n 
A 1 34  SER 34  34  34  SER SER A . n 
A 1 35  ASP 35  35  35  ASP ASP A . n 
A 1 36  ILE 36  36  36  ILE ILE A . n 
A 1 37  LEU 37  37  37  LEU LEU A . n 
A 1 38  GLN 38  38  38  GLN GLN A . n 
A 1 39  TYR 39  39  39  TYR TYR A . n 
A 1 40  ASP 40  40  40  ASP ASP A . n 
A 1 41  ALA 41  41  41  ALA ALA A . n 
A 1 42  SER 42  42  42  SER SER A . n 
A 1 43  LEU 43  43  43  LEU LEU A . n 
A 1 44  THR 44  44  44  THR THR A . n 
A 1 45  PRO 45  45  45  PRO PRO A . n 
A 1 46  LEU 46  46  46  LEU LEU A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  PHE 48  48  48  PHE PHE A . n 
A 1 49  GLN 49  49  49  GLN GLN A . n 
A 1 50  GLY 50  50  50  GLY GLY A . n 
A 1 51  TYR 51  51  51  TYR TYR A . n 
A 1 52  ASN 52  52  52  ASN ASN A . n 
A 1 53  LEU 53  53  53  LEU LEU A . n 
A 1 54  SER 54  54  54  SER SER A . n 
A 1 55  ALA 55  55  55  ALA ALA A . n 
A 1 56  ASN 56  56  56  ASN ASN A . n 
A 1 57  LYS 57  57  57  LYS LYS A . n 
A 1 58  GLN 58  58  58  GLN GLN A . n 
A 1 59  PHE 59  59  59  PHE PHE A . n 
A 1 60  LEU 60  60  60  LEU LEU A . n 
A 1 61  LEU 61  61  61  LEU LEU A . n 
A 1 62  THR 62  62  62  THR THR A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  ASN 64  64  64  ASN ASN A . n 
A 1 65  GLY 65  65  65  GLY GLY A . n 
A 1 66  HIS 66  66  66  HIS HIS A . n 
A 1 67  SER 67  67  67  SER SER A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  LYS 69  69  69  LYS LYS A . n 
A 1 70  LEU 70  70  70  LEU LEU A . n 
A 1 71  ASN 71  71  71  ASN ASN A . n 
A 1 72  LEU 72  72  72  LEU LEU A . n 
A 1 73  PRO 73  73  73  PRO PRO A . n 
A 1 74  SER 74  74  74  SER SER A . n 
A 1 75  ASP 75  75  75  ASP ASP A . n 
A 1 76  MET 76  76  76  MET MET A . n 
A 1 77  HIS 77  77  77  HIS HIS A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLN 79  79  79  GLN GLN A . n 
A 1 80  GLY 80  80  80  GLY GLY A . n 
A 1 81  LEU 81  81  81  LEU LEU A . n 
A 1 82  GLN 82  82  82  GLN GLN A . n 
A 1 83  SER 83  83  83  SER SER A . n 
A 1 84  ARG 84  84  84  ARG ARG A . n 
A 1 85  TYR 85  85  85  TYR TYR A . n 
A 1 86  SER 86  86  86  SER SER A . n 
A 1 87  ALA 87  87  87  ALA ALA A . n 
A 1 88  THR 88  88  88  THR THR A . n 
A 1 89  GLN 89  89  89  GLN GLN A . n 
A 1 90  LEU 90  90  90  LEU LEU A . n 
A 1 91  HIS 91  91  91  HIS HIS A . n 
A 1 92  LEU 92  92  92  LEU LEU A . n 
A 1 93  HIS 93  93  93  HIS HIS A . n 
A 1 94  TRP 94  94  94  TRP TRP A . n 
A 1 95  GLY 95  95  95  GLY GLY A . n 
A 1 96  ASN 96  96  96  ASN ASN A . n 
A 1 97  PRO 97  97  97  PRO PRO A . n 
A 1 98  ASN 98  98  98  ASN ASN A . n 
A 1 99  ASP 99  99  99  ASP ASP A . n 
A 1 100 PRO 100 100 100 PRO PRO A . n 
A 1 101 HIS 101 101 101 HIS HIS A . n 
A 1 102 GLY 102 102 102 GLY GLY A . n 
A 1 103 SER 103 103 103 SER SER A . n 
A 1 104 GLU 104 104 104 GLU GLU A . n 
A 1 105 HIS 105 105 105 HIS HIS A . n 
A 1 106 THR 106 106 106 THR THR A . n 
A 1 107 VAL 107 107 107 VAL VAL A . n 
A 1 108 SER 108 108 108 SER SER A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 HIS 111 111 111 HIS HIS A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 ALA 113 113 113 ALA ALA A . n 
A 1 114 ALA 114 114 114 ALA ALA A . n 
A 1 115 GLU 115 115 115 GLU GLU A . n 
A 1 116 LEU 116 116 116 LEU LEU A . n 
A 1 117 HIS 117 117 117 HIS HIS A . n 
A 1 118 ILE 118 118 118 ILE ILE A . n 
A 1 119 VAL 119 119 119 VAL VAL A . n 
A 1 120 HIS 120 120 120 HIS HIS A . n 
A 1 121 TYR 121 121 121 TYR TYR A . n 
A 1 122 ASN 122 122 122 ASN ASN A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 ASP 124 124 124 ASP ASP A . n 
A 1 125 LEU 125 125 125 LEU LEU A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 PRO 127 127 127 PRO PRO A . n 
A 1 128 ASP 128 128 128 ASP ASP A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 SER 130 130 130 SER SER A . n 
A 1 131 THR 131 131 131 THR THR A . n 
A 1 132 ALA 132 132 132 ALA ALA A . n 
A 1 133 SER 133 133 133 SER SER A . n 
A 1 134 ASN 134 134 134 ASN ASN A . n 
A 1 135 LYS 135 135 135 LYS LYS A . n 
A 1 136 SER 136 136 136 SER SER A . n 
A 1 137 GLU 137 137 137 GLU GLU A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 LEU 139 139 139 LEU LEU A . n 
A 1 140 ALA 140 140 140 ALA ALA A . n 
A 1 141 VAL 141 141 141 VAL VAL A . n 
A 1 142 LEU 142 142 142 LEU LEU A . n 
A 1 143 ALA 143 143 143 ALA ALA A . n 
A 1 144 VAL 144 144 144 VAL VAL A . n 
A 1 145 LEU 145 145 145 LEU LEU A . n 
A 1 146 ILE 146 146 146 ILE ILE A . n 
A 1 147 GLU 147 147 147 GLU GLU A . n 
A 1 148 MET 148 148 148 MET MET A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 SER 150 150 150 SER SER A . n 
A 1 151 PHE 151 151 151 PHE PHE A . n 
A 1 152 ASN 152 152 152 ASN ASN A . n 
A 1 153 PRO 153 153 153 PRO PRO A . n 
A 1 154 SER 154 154 154 SER SER A . n 
A 1 155 TYR 155 155 155 TYR TYR A . n 
A 1 156 ASP 156 156 156 ASP ASP A . n 
A 1 157 LYS 157 157 157 LYS LYS A . n 
A 1 158 ILE 158 158 158 ILE ILE A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 SER 160 160 160 SER SER A . n 
A 1 161 HIS 161 161 161 HIS HIS A . n 
A 1 162 LEU 162 162 162 LEU LEU A . n 
A 1 163 GLN 163 163 163 GLN GLN A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 VAL 165 165 165 VAL VAL A . n 
A 1 166 LYS 166 166 166 LYS LYS A . n 
A 1 167 TYR 167 167 167 TYR TYR A . n 
A 1 168 LYS 168 168 168 LYS LYS A . n 
A 1 169 GLY 169 169 169 GLY GLY A . n 
A 1 170 GLN 170 170 170 GLN GLN A . n 
A 1 171 GLU 171 171 171 GLU GLU A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 PHE 173 173 173 PHE PHE A . n 
A 1 174 VAL 174 174 174 VAL VAL A . n 
A 1 175 PRO 175 175 175 PRO PRO A . n 
A 1 176 GLY 176 176 176 GLY GLY A . n 
A 1 177 PHE 177 177 177 PHE PHE A . n 
A 1 178 ASN 178 178 178 ASN ASN A . n 
A 1 179 ILE 179 179 179 ILE ILE A . n 
A 1 180 GLU 180 180 180 GLU GLU A . n 
A 1 181 GLU 181 181 181 GLU GLU A . n 
A 1 182 LEU 182 182 182 LEU LEU A . n 
A 1 183 LEU 183 183 183 LEU LEU A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 GLU 185 185 185 GLU GLU A . n 
A 1 186 ARG 186 186 186 ARG ARG A . n 
A 1 187 THR 187 187 187 THR THR A . n 
A 1 188 ALA 188 188 188 ALA ALA A . n 
A 1 189 GLU 189 189 189 GLU GLU A . n 
A 1 190 TYR 190 190 190 TYR TYR A . n 
A 1 191 TYR 191 191 191 TYR TYR A . n 
A 1 192 ARG 192 192 192 ARG ARG A . n 
A 1 193 TYR 193 193 193 TYR TYR A . n 
A 1 194 ARG 194 194 194 ARG ARG A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 SER 196 196 196 SER SER A . n 
A 1 197 LEU 197 197 197 LEU LEU A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 PRO 200 200 200 PRO PRO A . n 
A 1 201 PRO 201 201 201 PRO PRO A . n 
A 1 202 CYS 202 202 202 CYS CYS A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 PRO 204 204 204 PRO PRO A . n 
A 1 205 THR 205 205 205 THR THR A . n 
A 1 206 VAL 206 206 206 VAL VAL A . n 
A 1 207 LEU 207 207 207 LEU LEU A . n 
A 1 208 TRP 208 208 208 TRP TRP A . n 
A 1 209 THR 209 209 209 THR THR A . n 
A 1 210 VAL 210 210 210 VAL VAL A . n 
A 1 211 PHE 211 211 211 PHE PHE A . n 
A 1 212 ARG 212 212 212 ARG ARG A . n 
A 1 213 ASN 213 213 213 ASN ASN A . n 
A 1 214 PRO 214 214 214 PRO PRO A . n 
A 1 215 VAL 215 215 215 VAL VAL A . n 
A 1 216 GLN 216 216 216 GLN GLN A . n 
A 1 217 ILE 217 217 217 ILE ILE A . n 
A 1 218 SER 218 218 218 SER SER A . n 
A 1 219 GLN 219 219 219 GLN GLN A . n 
A 1 220 GLU 220 220 220 GLU GLU A . n 
A 1 221 GLN 221 221 221 GLN GLN A . n 
A 1 222 LEU 222 222 222 LEU LEU A . n 
A 1 223 LEU 223 223 223 LEU LEU A . n 
A 1 224 ALA 224 224 224 ALA ALA A . n 
A 1 225 LEU 225 225 225 LEU LEU A . n 
A 1 226 GLU 226 226 226 GLU GLU A . n 
A 1 227 THR 227 227 227 THR THR A . n 
A 1 228 ALA 228 228 228 ALA ALA A . n 
A 1 229 LEU 229 229 229 LEU LEU A . n 
A 1 230 TYR 230 230 230 TYR TYR A . n 
A 1 231 CYS 231 231 231 CYS CYS A . n 
A 1 232 THR 232 232 232 THR THR A . n 
A 1 233 HIS 233 233 233 HIS HIS A . n 
A 1 234 MET 234 234 234 MET MET A . n 
A 1 235 ASP 235 235 235 ASP ASP A . n 
A 1 236 ASP 236 236 236 ASP ASP A . n 
A 1 237 PRO 237 237 237 PRO PRO A . n 
A 1 238 SER 238 238 238 SER SER A . n 
A 1 239 PRO 239 239 239 PRO PRO A . n 
A 1 240 ARG 240 240 240 ARG ARG A . n 
A 1 241 GLU 241 241 241 GLU GLU A . n 
A 1 242 MET 242 242 242 MET MET A . n 
A 1 243 ILE 243 243 243 ILE ILE A . n 
A 1 244 ASN 244 244 244 ASN ASN A . n 
A 1 245 ASN 245 245 245 ASN ASN A . n 
A 1 246 PHE 246 246 246 PHE PHE A . n 
A 1 247 ARG 247 247 247 ARG ARG A . n 
A 1 248 GLN 248 248 248 GLN GLN A . n 
A 1 249 VAL 249 249 249 VAL VAL A . n 
A 1 250 GLN 250 250 250 GLN GLN A . n 
A 1 251 LYS 251 251 251 LYS LYS A . n 
A 1 252 PHE 252 252 252 PHE PHE A . n 
A 1 253 ASP 253 253 253 ASP ASP A . n 
A 1 254 GLU 254 254 254 GLU GLU A . n 
A 1 255 ARG 255 255 255 ARG ARG A . n 
A 1 256 LEU 256 256 256 LEU LEU A . n 
A 1 257 VAL 257 257 257 VAL VAL A . n 
A 1 258 TYR 258 258 258 TYR TYR A . n 
A 1 259 THR 259 259 259 THR THR A . n 
A 1 260 SER 260 260 260 SER SER A . n 
A 1 261 PHE 261 261 261 PHE PHE A . n 
A 1 262 SER 262 262 262 SER SER A . n 
A 1 263 GLN 263 263 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   SER 2   2   ?   ?   ?   B . n 
B 1 3   LYS 3   3   3   LYS LYS B . n 
B 1 4   TRP 4   4   4   TRP TRP B . n 
B 1 5   THR 5   5   5   THR THR B . n 
B 1 6   TYR 6   6   6   TYR TYR B . n 
B 1 7   PHE 7   7   7   PHE PHE B . n 
B 1 8   GLY 8   8   8   GLY GLY B . n 
B 1 9   PRO 9   9   9   PRO PRO B . n 
B 1 10  ASP 10  10  10  ASP ASP B . n 
B 1 11  GLY 11  11  11  GLY GLY B . n 
B 1 12  GLU 12  12  12  GLU GLU B . n 
B 1 13  ASN 13  13  13  ASN ASN B . n 
B 1 14  SER 14  14  14  SER SER B . n 
B 1 15  TRP 15  15  15  TRP TRP B . n 
B 1 16  SER 16  16  16  SER SER B . n 
B 1 17  LYS 17  17  17  LYS LYS B . n 
B 1 18  LYS 18  18  18  LYS LYS B . n 
B 1 19  TYR 19  19  19  TYR TYR B . n 
B 1 20  PRO 20  20  20  PRO PRO B . n 
B 1 21  SER 21  21  21  SER SER B . n 
B 1 22  CYS 22  22  22  CYS CYS B . n 
B 1 23  GLY 23  23  23  GLY GLY B . n 
B 1 24  GLY 24  24  24  GLY GLY B . n 
B 1 25  LEU 25  25  25  LEU LEU B . n 
B 1 26  LEU 26  26  26  LEU LEU B . n 
B 1 27  GLN 27  27  27  GLN GLN B . n 
B 1 28  SER 28  28  28  SER SER B . n 
B 1 29  PRO 29  29  29  PRO PRO B . n 
B 1 30  ILE 30  30  30  ILE ILE B . n 
B 1 31  ASP 31  31  31  ASP ASP B . n 
B 1 32  LEU 32  32  32  LEU LEU B . n 
B 1 33  HIS 33  33  33  HIS HIS B . n 
B 1 34  SER 34  34  34  SER SER B . n 
B 1 35  ASP 35  35  35  ASP ASP B . n 
B 1 36  ILE 36  36  36  ILE ILE B . n 
B 1 37  LEU 37  37  37  LEU LEU B . n 
B 1 38  GLN 38  38  38  GLN GLN B . n 
B 1 39  TYR 39  39  39  TYR TYR B . n 
B 1 40  ASP 40  40  40  ASP ASP B . n 
B 1 41  ALA 41  41  41  ALA ALA B . n 
B 1 42  SER 42  42  42  SER SER B . n 
B 1 43  LEU 43  43  43  LEU LEU B . n 
B 1 44  THR 44  44  44  THR THR B . n 
B 1 45  PRO 45  45  45  PRO PRO B . n 
B 1 46  LEU 46  46  46  LEU LEU B . n 
B 1 47  GLU 47  47  47  GLU GLU B . n 
B 1 48  PHE 48  48  48  PHE PHE B . n 
B 1 49  GLN 49  49  49  GLN GLN B . n 
B 1 50  GLY 50  50  50  GLY GLY B . n 
B 1 51  TYR 51  51  51  TYR TYR B . n 
B 1 52  ASN 52  52  52  ASN ASN B . n 
B 1 53  LEU 53  53  53  LEU LEU B . n 
B 1 54  SER 54  54  54  SER SER B . n 
B 1 55  ALA 55  55  55  ALA ALA B . n 
B 1 56  ASN 56  56  56  ASN ASN B . n 
B 1 57  LYS 57  57  57  LYS LYS B . n 
B 1 58  GLN 58  58  58  GLN GLN B . n 
B 1 59  PHE 59  59  59  PHE PHE B . n 
B 1 60  LEU 60  60  60  LEU LEU B . n 
B 1 61  LEU 61  61  61  LEU LEU B . n 
B 1 62  THR 62  62  62  THR THR B . n 
B 1 63  ASN 63  63  63  ASN ASN B . n 
B 1 64  ASN 64  64  64  ASN ASN B . n 
B 1 65  GLY 65  65  65  GLY GLY B . n 
B 1 66  HIS 66  66  66  HIS HIS B . n 
B 1 67  SER 67  67  67  SER SER B . n 
B 1 68  VAL 68  68  68  VAL VAL B . n 
B 1 69  LYS 69  69  69  LYS LYS B . n 
B 1 70  LEU 70  70  70  LEU LEU B . n 
B 1 71  ASN 71  71  71  ASN ASN B . n 
B 1 72  LEU 72  72  72  LEU LEU B . n 
B 1 73  PRO 73  73  73  PRO PRO B . n 
B 1 74  SER 74  74  74  SER SER B . n 
B 1 75  ASP 75  75  75  ASP ASP B . n 
B 1 76  MET 76  76  76  MET MET B . n 
B 1 77  HIS 77  77  77  HIS HIS B . n 
B 1 78  ILE 78  78  78  ILE ILE B . n 
B 1 79  GLN 79  79  79  GLN GLN B . n 
B 1 80  GLY 80  80  80  GLY GLY B . n 
B 1 81  LEU 81  81  81  LEU LEU B . n 
B 1 82  GLN 82  82  82  GLN GLN B . n 
B 1 83  SER 83  83  83  SER SER B . n 
B 1 84  ARG 84  84  84  ARG ARG B . n 
B 1 85  TYR 85  85  85  TYR TYR B . n 
B 1 86  SER 86  86  86  SER SER B . n 
B 1 87  ALA 87  87  87  ALA ALA B . n 
B 1 88  THR 88  88  88  THR THR B . n 
B 1 89  GLN 89  89  89  GLN GLN B . n 
B 1 90  LEU 90  90  90  LEU LEU B . n 
B 1 91  HIS 91  91  91  HIS HIS B . n 
B 1 92  LEU 92  92  92  LEU LEU B . n 
B 1 93  HIS 93  93  93  HIS HIS B . n 
B 1 94  TRP 94  94  94  TRP TRP B . n 
B 1 95  GLY 95  95  95  GLY GLY B . n 
B 1 96  ASN 96  96  96  ASN ASN B . n 
B 1 97  PRO 97  97  97  PRO PRO B . n 
B 1 98  ASN 98  98  98  ASN ASN B . n 
B 1 99  ASP 99  99  99  ASP ASP B . n 
B 1 100 PRO 100 100 100 PRO PRO B . n 
B 1 101 HIS 101 101 101 HIS HIS B . n 
B 1 102 GLY 102 102 102 GLY GLY B . n 
B 1 103 SER 103 103 103 SER SER B . n 
B 1 104 GLU 104 104 104 GLU GLU B . n 
B 1 105 HIS 105 105 105 HIS HIS B . n 
B 1 106 THR 106 106 106 THR THR B . n 
B 1 107 VAL 107 107 107 VAL VAL B . n 
B 1 108 SER 108 108 108 SER SER B . n 
B 1 109 GLY 109 109 109 GLY GLY B . n 
B 1 110 GLN 110 110 110 GLN GLN B . n 
B 1 111 HIS 111 111 111 HIS HIS B . n 
B 1 112 PHE 112 112 112 PHE PHE B . n 
B 1 113 ALA 113 113 113 ALA ALA B . n 
B 1 114 ALA 114 114 114 ALA ALA B . n 
B 1 115 GLU 115 115 115 GLU GLU B . n 
B 1 116 LEU 116 116 116 LEU LEU B . n 
B 1 117 HIS 117 117 117 HIS HIS B . n 
B 1 118 ILE 118 118 118 ILE ILE B . n 
B 1 119 VAL 119 119 119 VAL VAL B . n 
B 1 120 HIS 120 120 120 HIS HIS B . n 
B 1 121 TYR 121 121 121 TYR TYR B . n 
B 1 122 ASN 122 122 122 ASN ASN B . n 
B 1 123 SER 123 123 123 SER SER B . n 
B 1 124 ASP 124 124 124 ASP ASP B . n 
B 1 125 LEU 125 125 125 LEU LEU B . n 
B 1 126 TYR 126 126 126 TYR TYR B . n 
B 1 127 PRO 127 127 127 PRO PRO B . n 
B 1 128 ASP 128 128 128 ASP ASP B . n 
B 1 129 ALA 129 129 129 ALA ALA B . n 
B 1 130 SER 130 130 130 SER SER B . n 
B 1 131 THR 131 131 131 THR THR B . n 
B 1 132 ALA 132 132 132 ALA ALA B . n 
B 1 133 SER 133 133 133 SER SER B . n 
B 1 134 ASN 134 134 134 ASN ASN B . n 
B 1 135 LYS 135 135 135 LYS LYS B . n 
B 1 136 SER 136 136 136 SER SER B . n 
B 1 137 GLU 137 137 137 GLU GLU B . n 
B 1 138 GLY 138 138 138 GLY GLY B . n 
B 1 139 LEU 139 139 139 LEU LEU B . n 
B 1 140 ALA 140 140 140 ALA ALA B . n 
B 1 141 VAL 141 141 141 VAL VAL B . n 
B 1 142 LEU 142 142 142 LEU LEU B . n 
B 1 143 ALA 143 143 143 ALA ALA B . n 
B 1 144 VAL 144 144 144 VAL VAL B . n 
B 1 145 LEU 145 145 145 LEU LEU B . n 
B 1 146 ILE 146 146 146 ILE ILE B . n 
B 1 147 GLU 147 147 147 GLU GLU B . n 
B 1 148 MET 148 148 148 MET MET B . n 
B 1 149 GLY 149 149 149 GLY GLY B . n 
B 1 150 SER 150 150 150 SER SER B . n 
B 1 151 PHE 151 151 151 PHE PHE B . n 
B 1 152 ASN 152 152 152 ASN ASN B . n 
B 1 153 PRO 153 153 153 PRO PRO B . n 
B 1 154 SER 154 154 154 SER SER B . n 
B 1 155 TYR 155 155 155 TYR TYR B . n 
B 1 156 ASP 156 156 156 ASP ASP B . n 
B 1 157 LYS 157 157 157 LYS LYS B . n 
B 1 158 ILE 158 158 158 ILE ILE B . n 
B 1 159 PHE 159 159 159 PHE PHE B . n 
B 1 160 SER 160 160 160 SER SER B . n 
B 1 161 HIS 161 161 161 HIS HIS B . n 
B 1 162 LEU 162 162 162 LEU LEU B . n 
B 1 163 GLN 163 163 163 GLN GLN B . n 
B 1 164 HIS 164 164 164 HIS HIS B . n 
B 1 165 VAL 165 165 165 VAL VAL B . n 
B 1 166 LYS 166 166 166 LYS LYS B . n 
B 1 167 TYR 167 167 167 TYR TYR B . n 
B 1 168 LYS 168 168 168 LYS LYS B . n 
B 1 169 GLY 169 169 169 GLY GLY B . n 
B 1 170 GLN 170 170 170 GLN GLN B . n 
B 1 171 GLU 171 171 171 GLU GLU B . n 
B 1 172 ALA 172 172 172 ALA ALA B . n 
B 1 173 PHE 173 173 173 PHE PHE B . n 
B 1 174 VAL 174 174 174 VAL VAL B . n 
B 1 175 PRO 175 175 175 PRO PRO B . n 
B 1 176 GLY 176 176 176 GLY GLY B . n 
B 1 177 PHE 177 177 177 PHE PHE B . n 
B 1 178 ASN 178 178 178 ASN ASN B . n 
B 1 179 ILE 179 179 179 ILE ILE B . n 
B 1 180 GLU 180 180 180 GLU GLU B . n 
B 1 181 GLU 181 181 181 GLU GLU B . n 
B 1 182 LEU 182 182 182 LEU LEU B . n 
B 1 183 LEU 183 183 183 LEU LEU B . n 
B 1 184 PRO 184 184 184 PRO PRO B . n 
B 1 185 GLU 185 185 185 GLU GLU B . n 
B 1 186 ARG 186 186 186 ARG ARG B . n 
B 1 187 THR 187 187 187 THR THR B . n 
B 1 188 ALA 188 188 188 ALA ALA B . n 
B 1 189 GLU 189 189 189 GLU GLU B . n 
B 1 190 TYR 190 190 190 TYR TYR B . n 
B 1 191 TYR 191 191 191 TYR TYR B . n 
B 1 192 ARG 192 192 192 ARG ARG B . n 
B 1 193 TYR 193 193 193 TYR TYR B . n 
B 1 194 ARG 194 194 194 ARG ARG B . n 
B 1 195 GLY 195 195 195 GLY GLY B . n 
B 1 196 SER 196 196 196 SER SER B . n 
B 1 197 LEU 197 197 197 LEU LEU B . n 
B 1 198 THR 198 198 198 THR THR B . n 
B 1 199 THR 199 199 199 THR THR B . n 
B 1 200 PRO 200 200 200 PRO PRO B . n 
B 1 201 PRO 201 201 201 PRO PRO B . n 
B 1 202 CYS 202 202 202 CYS CYS B . n 
B 1 203 ASN 203 203 203 ASN ASN B . n 
B 1 204 PRO 204 204 204 PRO PRO B . n 
B 1 205 THR 205 205 205 THR THR B . n 
B 1 206 VAL 206 206 206 VAL VAL B . n 
B 1 207 LEU 207 207 207 LEU LEU B . n 
B 1 208 TRP 208 208 208 TRP TRP B . n 
B 1 209 THR 209 209 209 THR THR B . n 
B 1 210 VAL 210 210 210 VAL VAL B . n 
B 1 211 PHE 211 211 211 PHE PHE B . n 
B 1 212 ARG 212 212 212 ARG ARG B . n 
B 1 213 ASN 213 213 213 ASN ASN B . n 
B 1 214 PRO 214 214 214 PRO PRO B . n 
B 1 215 VAL 215 215 215 VAL VAL B . n 
B 1 216 GLN 216 216 216 GLN GLN B . n 
B 1 217 ILE 217 217 217 ILE ILE B . n 
B 1 218 SER 218 218 218 SER SER B . n 
B 1 219 GLN 219 219 219 GLN GLN B . n 
B 1 220 GLU 220 220 220 GLU GLU B . n 
B 1 221 GLN 221 221 221 GLN GLN B . n 
B 1 222 LEU 222 222 222 LEU LEU B . n 
B 1 223 LEU 223 223 223 LEU LEU B . n 
B 1 224 ALA 224 224 224 ALA ALA B . n 
B 1 225 LEU 225 225 225 LEU LEU B . n 
B 1 226 GLU 226 226 226 GLU GLU B . n 
B 1 227 THR 227 227 227 THR THR B . n 
B 1 228 ALA 228 228 228 ALA ALA B . n 
B 1 229 LEU 229 229 229 LEU LEU B . n 
B 1 230 TYR 230 230 230 TYR TYR B . n 
B 1 231 CYS 231 231 231 CYS CYS B . n 
B 1 232 THR 232 232 232 THR THR B . n 
B 1 233 HIS 233 233 233 HIS HIS B . n 
B 1 234 MET 234 234 234 MET MET B . n 
B 1 235 ASP 235 235 235 ASP ASP B . n 
B 1 236 ASP 236 236 236 ASP ASP B . n 
B 1 237 PRO 237 237 237 PRO PRO B . n 
B 1 238 SER 238 238 238 SER SER B . n 
B 1 239 PRO 239 239 239 PRO PRO B . n 
B 1 240 ARG 240 240 240 ARG ARG B . n 
B 1 241 GLU 241 241 241 GLU GLU B . n 
B 1 242 MET 242 242 242 MET MET B . n 
B 1 243 ILE 243 243 243 ILE ILE B . n 
B 1 244 ASN 244 244 244 ASN ASN B . n 
B 1 245 ASN 245 245 245 ASN ASN B . n 
B 1 246 PHE 246 246 246 PHE PHE B . n 
B 1 247 ARG 247 247 247 ARG ARG B . n 
B 1 248 GLN 248 248 248 GLN GLN B . n 
B 1 249 VAL 249 249 249 VAL VAL B . n 
B 1 250 GLN 250 250 250 GLN GLN B . n 
B 1 251 LYS 251 251 251 LYS LYS B . n 
B 1 252 PHE 252 252 252 PHE PHE B . n 
B 1 253 ASP 253 253 253 ASP ASP B . n 
B 1 254 GLU 254 254 254 GLU GLU B . n 
B 1 255 ARG 255 255 255 ARG ARG B . n 
B 1 256 LEU 256 256 256 LEU LEU B . n 
B 1 257 VAL 257 257 257 VAL VAL B . n 
B 1 258 TYR 258 258 258 TYR TYR B . n 
B 1 259 THR 259 259 259 THR THR B . n 
B 1 260 SER 260 260 260 SER SER B . n 
B 1 261 PHE 261 261 261 PHE PHE B . n 
B 1 262 SER 262 262 262 SER SER B . n 
B 1 263 GLN 263 263 263 GLN GLN B . n 
C 1 1   MET 1   1   ?   ?   ?   C . n 
C 1 2   SER 2   2   ?   ?   ?   C . n 
C 1 3   LYS 3   3   3   LYS LYS C . n 
C 1 4   TRP 4   4   4   TRP TRP C . n 
C 1 5   THR 5   5   5   THR THR C . n 
C 1 6   TYR 6   6   6   TYR TYR C . n 
C 1 7   PHE 7   7   7   PHE PHE C . n 
C 1 8   GLY 8   8   8   GLY GLY C . n 
C 1 9   PRO 9   9   9   PRO PRO C . n 
C 1 10  ASP 10  10  10  ASP ASP C . n 
C 1 11  GLY 11  11  11  GLY GLY C . n 
C 1 12  GLU 12  12  12  GLU GLU C . n 
C 1 13  ASN 13  13  13  ASN ASN C . n 
C 1 14  SER 14  14  14  SER SER C . n 
C 1 15  TRP 15  15  15  TRP TRP C . n 
C 1 16  SER 16  16  16  SER SER C . n 
C 1 17  LYS 17  17  17  LYS LYS C . n 
C 1 18  LYS 18  18  18  LYS LYS C . n 
C 1 19  TYR 19  19  19  TYR TYR C . n 
C 1 20  PRO 20  20  20  PRO PRO C . n 
C 1 21  SER 21  21  21  SER SER C . n 
C 1 22  CYS 22  22  22  CYS CYS C . n 
C 1 23  GLY 23  23  23  GLY GLY C . n 
C 1 24  GLY 24  24  24  GLY GLY C . n 
C 1 25  LEU 25  25  25  LEU LEU C . n 
C 1 26  LEU 26  26  26  LEU LEU C . n 
C 1 27  GLN 27  27  27  GLN GLN C . n 
C 1 28  SER 28  28  28  SER SER C . n 
C 1 29  PRO 29  29  29  PRO PRO C . n 
C 1 30  ILE 30  30  30  ILE ILE C . n 
C 1 31  ASP 31  31  31  ASP ASP C . n 
C 1 32  LEU 32  32  32  LEU LEU C . n 
C 1 33  HIS 33  33  33  HIS HIS C . n 
C 1 34  SER 34  34  34  SER SER C . n 
C 1 35  ASP 35  35  35  ASP ASP C . n 
C 1 36  ILE 36  36  36  ILE ILE C . n 
C 1 37  LEU 37  37  37  LEU LEU C . n 
C 1 38  GLN 38  38  38  GLN GLN C . n 
C 1 39  TYR 39  39  39  TYR TYR C . n 
C 1 40  ASP 40  40  40  ASP ASP C . n 
C 1 41  ALA 41  41  41  ALA ALA C . n 
C 1 42  SER 42  42  42  SER SER C . n 
C 1 43  LEU 43  43  43  LEU LEU C . n 
C 1 44  THR 44  44  44  THR THR C . n 
C 1 45  PRO 45  45  45  PRO PRO C . n 
C 1 46  LEU 46  46  46  LEU LEU C . n 
C 1 47  GLU 47  47  47  GLU GLU C . n 
C 1 48  PHE 48  48  48  PHE PHE C . n 
C 1 49  GLN 49  49  49  GLN GLN C . n 
C 1 50  GLY 50  50  50  GLY GLY C . n 
C 1 51  TYR 51  51  51  TYR TYR C . n 
C 1 52  ASN 52  52  52  ASN ASN C . n 
C 1 53  LEU 53  53  53  LEU LEU C . n 
C 1 54  SER 54  54  54  SER SER C . n 
C 1 55  ALA 55  55  55  ALA ALA C . n 
C 1 56  ASN 56  56  56  ASN ASN C . n 
C 1 57  LYS 57  57  57  LYS LYS C . n 
C 1 58  GLN 58  58  58  GLN GLN C . n 
C 1 59  PHE 59  59  59  PHE PHE C . n 
C 1 60  LEU 60  60  60  LEU LEU C . n 
C 1 61  LEU 61  61  61  LEU LEU C . n 
C 1 62  THR 62  62  62  THR THR C . n 
C 1 63  ASN 63  63  63  ASN ASN C . n 
C 1 64  ASN 64  64  64  ASN ASN C . n 
C 1 65  GLY 65  65  65  GLY GLY C . n 
C 1 66  HIS 66  66  66  HIS HIS C . n 
C 1 67  SER 67  67  67  SER SER C . n 
C 1 68  VAL 68  68  68  VAL VAL C . n 
C 1 69  LYS 69  69  69  LYS LYS C . n 
C 1 70  LEU 70  70  70  LEU LEU C . n 
C 1 71  ASN 71  71  71  ASN ASN C . n 
C 1 72  LEU 72  72  72  LEU LEU C . n 
C 1 73  PRO 73  73  73  PRO PRO C . n 
C 1 74  SER 74  74  74  SER SER C . n 
C 1 75  ASP 75  75  75  ASP ASP C . n 
C 1 76  MET 76  76  76  MET MET C . n 
C 1 77  HIS 77  77  77  HIS HIS C . n 
C 1 78  ILE 78  78  78  ILE ILE C . n 
C 1 79  GLN 79  79  79  GLN GLN C . n 
C 1 80  GLY 80  80  80  GLY GLY C . n 
C 1 81  LEU 81  81  81  LEU LEU C . n 
C 1 82  GLN 82  82  82  GLN GLN C . n 
C 1 83  SER 83  83  83  SER SER C . n 
C 1 84  ARG 84  84  84  ARG ARG C . n 
C 1 85  TYR 85  85  85  TYR TYR C . n 
C 1 86  SER 86  86  86  SER SER C . n 
C 1 87  ALA 87  87  87  ALA ALA C . n 
C 1 88  THR 88  88  88  THR THR C . n 
C 1 89  GLN 89  89  89  GLN GLN C . n 
C 1 90  LEU 90  90  90  LEU LEU C . n 
C 1 91  HIS 91  91  91  HIS HIS C . n 
C 1 92  LEU 92  92  92  LEU LEU C . n 
C 1 93  HIS 93  93  93  HIS HIS C . n 
C 1 94  TRP 94  94  94  TRP TRP C . n 
C 1 95  GLY 95  95  95  GLY GLY C . n 
C 1 96  ASN 96  96  96  ASN ASN C . n 
C 1 97  PRO 97  97  97  PRO PRO C . n 
C 1 98  ASN 98  98  98  ASN ASN C . n 
C 1 99  ASP 99  99  99  ASP ASP C . n 
C 1 100 PRO 100 100 100 PRO PRO C . n 
C 1 101 HIS 101 101 101 HIS HIS C . n 
C 1 102 GLY 102 102 102 GLY GLY C . n 
C 1 103 SER 103 103 103 SER SER C . n 
C 1 104 GLU 104 104 104 GLU GLU C . n 
C 1 105 HIS 105 105 105 HIS HIS C . n 
C 1 106 THR 106 106 106 THR THR C . n 
C 1 107 VAL 107 107 107 VAL VAL C . n 
C 1 108 SER 108 108 108 SER SER C . n 
C 1 109 GLY 109 109 109 GLY GLY C . n 
C 1 110 GLN 110 110 110 GLN GLN C . n 
C 1 111 HIS 111 111 111 HIS HIS C . n 
C 1 112 PHE 112 112 112 PHE PHE C . n 
C 1 113 ALA 113 113 113 ALA ALA C . n 
C 1 114 ALA 114 114 114 ALA ALA C . n 
C 1 115 GLU 115 115 115 GLU GLU C . n 
C 1 116 LEU 116 116 116 LEU LEU C . n 
C 1 117 HIS 117 117 117 HIS HIS C . n 
C 1 118 ILE 118 118 118 ILE ILE C . n 
C 1 119 VAL 119 119 119 VAL VAL C . n 
C 1 120 HIS 120 120 120 HIS HIS C . n 
C 1 121 TYR 121 121 121 TYR TYR C . n 
C 1 122 ASN 122 122 122 ASN ASN C . n 
C 1 123 SER 123 123 123 SER SER C . n 
C 1 124 ASP 124 124 124 ASP ASP C . n 
C 1 125 LEU 125 125 125 LEU LEU C . n 
C 1 126 TYR 126 126 126 TYR TYR C . n 
C 1 127 PRO 127 127 127 PRO PRO C . n 
C 1 128 ASP 128 128 128 ASP ASP C . n 
C 1 129 ALA 129 129 129 ALA ALA C . n 
C 1 130 SER 130 130 130 SER SER C . n 
C 1 131 THR 131 131 131 THR THR C . n 
C 1 132 ALA 132 132 132 ALA ALA C . n 
C 1 133 SER 133 133 133 SER SER C . n 
C 1 134 ASN 134 134 134 ASN ASN C . n 
C 1 135 LYS 135 135 135 LYS LYS C . n 
C 1 136 SER 136 136 136 SER SER C . n 
C 1 137 GLU 137 137 137 GLU GLU C . n 
C 1 138 GLY 138 138 138 GLY GLY C . n 
C 1 139 LEU 139 139 139 LEU LEU C . n 
C 1 140 ALA 140 140 140 ALA ALA C . n 
C 1 141 VAL 141 141 141 VAL VAL C . n 
C 1 142 LEU 142 142 142 LEU LEU C . n 
C 1 143 ALA 143 143 143 ALA ALA C . n 
C 1 144 VAL 144 144 144 VAL VAL C . n 
C 1 145 LEU 145 145 145 LEU LEU C . n 
C 1 146 ILE 146 146 146 ILE ILE C . n 
C 1 147 GLU 147 147 147 GLU GLU C . n 
C 1 148 MET 148 148 148 MET MET C . n 
C 1 149 GLY 149 149 149 GLY GLY C . n 
C 1 150 SER 150 150 150 SER SER C . n 
C 1 151 PHE 151 151 151 PHE PHE C . n 
C 1 152 ASN 152 152 152 ASN ASN C . n 
C 1 153 PRO 153 153 153 PRO PRO C . n 
C 1 154 SER 154 154 154 SER SER C . n 
C 1 155 TYR 155 155 155 TYR TYR C . n 
C 1 156 ASP 156 156 156 ASP ASP C . n 
C 1 157 LYS 157 157 157 LYS LYS C . n 
C 1 158 ILE 158 158 158 ILE ILE C . n 
C 1 159 PHE 159 159 159 PHE PHE C . n 
C 1 160 SER 160 160 160 SER SER C . n 
C 1 161 HIS 161 161 161 HIS HIS C . n 
C 1 162 LEU 162 162 162 LEU LEU C . n 
C 1 163 GLN 163 163 163 GLN GLN C . n 
C 1 164 HIS 164 164 164 HIS HIS C . n 
C 1 165 VAL 165 165 165 VAL VAL C . n 
C 1 166 LYS 166 166 166 LYS LYS C . n 
C 1 167 TYR 167 167 167 TYR TYR C . n 
C 1 168 LYS 168 168 168 LYS LYS C . n 
C 1 169 GLY 169 169 169 GLY GLY C . n 
C 1 170 GLN 170 170 170 GLN GLN C . n 
C 1 171 GLU 171 171 171 GLU GLU C . n 
C 1 172 ALA 172 172 172 ALA ALA C . n 
C 1 173 PHE 173 173 173 PHE PHE C . n 
C 1 174 VAL 174 174 174 VAL VAL C . n 
C 1 175 PRO 175 175 175 PRO PRO C . n 
C 1 176 GLY 176 176 176 GLY GLY C . n 
C 1 177 PHE 177 177 177 PHE PHE C . n 
C 1 178 ASN 178 178 178 ASN ASN C . n 
C 1 179 ILE 179 179 179 ILE ILE C . n 
C 1 180 GLU 180 180 180 GLU GLU C . n 
C 1 181 GLU 181 181 181 GLU GLU C . n 
C 1 182 LEU 182 182 182 LEU LEU C . n 
C 1 183 LEU 183 183 183 LEU LEU C . n 
C 1 184 PRO 184 184 184 PRO PRO C . n 
C 1 185 GLU 185 185 185 GLU GLU C . n 
C 1 186 ARG 186 186 186 ARG ARG C . n 
C 1 187 THR 187 187 187 THR THR C . n 
C 1 188 ALA 188 188 188 ALA ALA C . n 
C 1 189 GLU 189 189 189 GLU GLU C . n 
C 1 190 TYR 190 190 190 TYR TYR C . n 
C 1 191 TYR 191 191 191 TYR TYR C . n 
C 1 192 ARG 192 192 192 ARG ARG C . n 
C 1 193 TYR 193 193 193 TYR TYR C . n 
C 1 194 ARG 194 194 194 ARG ARG C . n 
C 1 195 GLY 195 195 195 GLY GLY C . n 
C 1 196 SER 196 196 196 SER SER C . n 
C 1 197 LEU 197 197 197 LEU LEU C . n 
C 1 198 THR 198 198 198 THR THR C . n 
C 1 199 THR 199 199 199 THR THR C . n 
C 1 200 PRO 200 200 200 PRO PRO C . n 
C 1 201 PRO 201 201 201 PRO PRO C . n 
C 1 202 CYS 202 202 202 CYS CYS C . n 
C 1 203 ASN 203 203 203 ASN ASN C . n 
C 1 204 PRO 204 204 204 PRO PRO C . n 
C 1 205 THR 205 205 205 THR THR C . n 
C 1 206 VAL 206 206 206 VAL VAL C . n 
C 1 207 LEU 207 207 207 LEU LEU C . n 
C 1 208 TRP 208 208 208 TRP TRP C . n 
C 1 209 THR 209 209 209 THR THR C . n 
C 1 210 VAL 210 210 210 VAL VAL C . n 
C 1 211 PHE 211 211 211 PHE PHE C . n 
C 1 212 ARG 212 212 212 ARG ARG C . n 
C 1 213 ASN 213 213 213 ASN ASN C . n 
C 1 214 PRO 214 214 214 PRO PRO C . n 
C 1 215 VAL 215 215 215 VAL VAL C . n 
C 1 216 GLN 216 216 216 GLN GLN C . n 
C 1 217 ILE 217 217 217 ILE ILE C . n 
C 1 218 SER 218 218 218 SER SER C . n 
C 1 219 GLN 219 219 219 GLN GLN C . n 
C 1 220 GLU 220 220 220 GLU GLU C . n 
C 1 221 GLN 221 221 221 GLN GLN C . n 
C 1 222 LEU 222 222 222 LEU LEU C . n 
C 1 223 LEU 223 223 223 LEU LEU C . n 
C 1 224 ALA 224 224 224 ALA ALA C . n 
C 1 225 LEU 225 225 225 LEU LEU C . n 
C 1 226 GLU 226 226 226 GLU GLU C . n 
C 1 227 THR 227 227 227 THR THR C . n 
C 1 228 ALA 228 228 228 ALA ALA C . n 
C 1 229 LEU 229 229 229 LEU LEU C . n 
C 1 230 TYR 230 230 230 TYR TYR C . n 
C 1 231 CYS 231 231 231 CYS CYS C . n 
C 1 232 THR 232 232 232 THR THR C . n 
C 1 233 HIS 233 233 233 HIS HIS C . n 
C 1 234 MET 234 234 234 MET MET C . n 
C 1 235 ASP 235 235 235 ASP ASP C . n 
C 1 236 ASP 236 236 236 ASP ASP C . n 
C 1 237 PRO 237 237 237 PRO PRO C . n 
C 1 238 SER 238 238 238 SER SER C . n 
C 1 239 PRO 239 239 239 PRO PRO C . n 
C 1 240 ARG 240 240 240 ARG ARG C . n 
C 1 241 GLU 241 241 241 GLU GLU C . n 
C 1 242 MET 242 242 242 MET MET C . n 
C 1 243 ILE 243 243 243 ILE ILE C . n 
C 1 244 ASN 244 244 244 ASN ASN C . n 
C 1 245 ASN 245 245 245 ASN ASN C . n 
C 1 246 PHE 246 246 246 PHE PHE C . n 
C 1 247 ARG 247 247 247 ARG ARG C . n 
C 1 248 GLN 248 248 248 GLN GLN C . n 
C 1 249 VAL 249 249 249 VAL VAL C . n 
C 1 250 GLN 250 250 250 GLN GLN C . n 
C 1 251 LYS 251 251 251 LYS LYS C . n 
C 1 252 PHE 252 252 252 PHE PHE C . n 
C 1 253 ASP 253 253 253 ASP ASP C . n 
C 1 254 GLU 254 254 254 GLU GLU C . n 
C 1 255 ARG 255 255 255 ARG ARG C . n 
C 1 256 LEU 256 256 256 LEU LEU C . n 
C 1 257 VAL 257 257 257 VAL VAL C . n 
C 1 258 TYR 258 258 258 TYR TYR C . n 
C 1 259 THR 259 259 259 THR THR C . n 
C 1 260 SER 260 260 260 SER SER C . n 
C 1 261 PHE 261 261 261 PHE PHE C . n 
C 1 262 SER 262 262 262 SER SER C . n 
C 1 263 GLN 263 263 ?   ?   ?   C . n 
D 1 1   MET 1   1   ?   ?   ?   D . n 
D 1 2   SER 2   2   ?   ?   ?   D . n 
D 1 3   LYS 3   3   3   LYS LYS D . n 
D 1 4   TRP 4   4   4   TRP TRP D . n 
D 1 5   THR 5   5   5   THR THR D . n 
D 1 6   TYR 6   6   6   TYR TYR D . n 
D 1 7   PHE 7   7   7   PHE PHE D . n 
D 1 8   GLY 8   8   8   GLY GLY D . n 
D 1 9   PRO 9   9   9   PRO PRO D . n 
D 1 10  ASP 10  10  10  ASP ASP D . n 
D 1 11  GLY 11  11  11  GLY GLY D . n 
D 1 12  GLU 12  12  12  GLU GLU D . n 
D 1 13  ASN 13  13  13  ASN ASN D . n 
D 1 14  SER 14  14  14  SER SER D . n 
D 1 15  TRP 15  15  15  TRP TRP D . n 
D 1 16  SER 16  16  16  SER SER D . n 
D 1 17  LYS 17  17  17  LYS LYS D . n 
D 1 18  LYS 18  18  18  LYS LYS D . n 
D 1 19  TYR 19  19  19  TYR TYR D . n 
D 1 20  PRO 20  20  20  PRO PRO D . n 
D 1 21  SER 21  21  21  SER SER D . n 
D 1 22  CYS 22  22  22  CYS CYS D . n 
D 1 23  GLY 23  23  23  GLY GLY D . n 
D 1 24  GLY 24  24  24  GLY GLY D . n 
D 1 25  LEU 25  25  25  LEU LEU D . n 
D 1 26  LEU 26  26  26  LEU LEU D . n 
D 1 27  GLN 27  27  27  GLN GLN D . n 
D 1 28  SER 28  28  28  SER SER D . n 
D 1 29  PRO 29  29  29  PRO PRO D . n 
D 1 30  ILE 30  30  30  ILE ILE D . n 
D 1 31  ASP 31  31  31  ASP ASP D . n 
D 1 32  LEU 32  32  32  LEU LEU D . n 
D 1 33  HIS 33  33  33  HIS HIS D . n 
D 1 34  SER 34  34  34  SER SER D . n 
D 1 35  ASP 35  35  35  ASP ASP D . n 
D 1 36  ILE 36  36  36  ILE ILE D . n 
D 1 37  LEU 37  37  37  LEU LEU D . n 
D 1 38  GLN 38  38  38  GLN GLN D . n 
D 1 39  TYR 39  39  39  TYR TYR D . n 
D 1 40  ASP 40  40  40  ASP ASP D . n 
D 1 41  ALA 41  41  41  ALA ALA D . n 
D 1 42  SER 42  42  42  SER SER D . n 
D 1 43  LEU 43  43  43  LEU LEU D . n 
D 1 44  THR 44  44  44  THR THR D . n 
D 1 45  PRO 45  45  45  PRO PRO D . n 
D 1 46  LEU 46  46  46  LEU LEU D . n 
D 1 47  GLU 47  47  47  GLU GLU D . n 
D 1 48  PHE 48  48  48  PHE PHE D . n 
D 1 49  GLN 49  49  49  GLN GLN D . n 
D 1 50  GLY 50  50  50  GLY GLY D . n 
D 1 51  TYR 51  51  51  TYR TYR D . n 
D 1 52  ASN 52  52  52  ASN ASN D . n 
D 1 53  LEU 53  53  53  LEU LEU D . n 
D 1 54  SER 54  54  54  SER SER D . n 
D 1 55  ALA 55  55  55  ALA ALA D . n 
D 1 56  ASN 56  56  56  ASN ASN D . n 
D 1 57  LYS 57  57  57  LYS LYS D . n 
D 1 58  GLN 58  58  58  GLN GLN D . n 
D 1 59  PHE 59  59  59  PHE PHE D . n 
D 1 60  LEU 60  60  60  LEU LEU D . n 
D 1 61  LEU 61  61  61  LEU LEU D . n 
D 1 62  THR 62  62  62  THR THR D . n 
D 1 63  ASN 63  63  63  ASN ASN D . n 
D 1 64  ASN 64  64  64  ASN ASN D . n 
D 1 65  GLY 65  65  65  GLY GLY D . n 
D 1 66  HIS 66  66  66  HIS HIS D . n 
D 1 67  SER 67  67  67  SER SER D . n 
D 1 68  VAL 68  68  68  VAL VAL D . n 
D 1 69  LYS 69  69  69  LYS LYS D . n 
D 1 70  LEU 70  70  70  LEU LEU D . n 
D 1 71  ASN 71  71  71  ASN ASN D . n 
D 1 72  LEU 72  72  72  LEU LEU D . n 
D 1 73  PRO 73  73  73  PRO PRO D . n 
D 1 74  SER 74  74  74  SER SER D . n 
D 1 75  ASP 75  75  75  ASP ASP D . n 
D 1 76  MET 76  76  76  MET MET D . n 
D 1 77  HIS 77  77  77  HIS HIS D . n 
D 1 78  ILE 78  78  78  ILE ILE D . n 
D 1 79  GLN 79  79  79  GLN GLN D . n 
D 1 80  GLY 80  80  80  GLY GLY D . n 
D 1 81  LEU 81  81  81  LEU LEU D . n 
D 1 82  GLN 82  82  82  GLN GLN D . n 
D 1 83  SER 83  83  83  SER SER D . n 
D 1 84  ARG 84  84  84  ARG ARG D . n 
D 1 85  TYR 85  85  85  TYR TYR D . n 
D 1 86  SER 86  86  86  SER SER D . n 
D 1 87  ALA 87  87  87  ALA ALA D . n 
D 1 88  THR 88  88  88  THR THR D . n 
D 1 89  GLN 89  89  89  GLN GLN D . n 
D 1 90  LEU 90  90  90  LEU LEU D . n 
D 1 91  HIS 91  91  91  HIS HIS D . n 
D 1 92  LEU 92  92  92  LEU LEU D . n 
D 1 93  HIS 93  93  93  HIS HIS D . n 
D 1 94  TRP 94  94  94  TRP TRP D . n 
D 1 95  GLY 95  95  95  GLY GLY D . n 
D 1 96  ASN 96  96  96  ASN ASN D . n 
D 1 97  PRO 97  97  97  PRO PRO D . n 
D 1 98  ASN 98  98  98  ASN ASN D . n 
D 1 99  ASP 99  99  99  ASP ASP D . n 
D 1 100 PRO 100 100 100 PRO PRO D . n 
D 1 101 HIS 101 101 101 HIS HIS D . n 
D 1 102 GLY 102 102 102 GLY GLY D . n 
D 1 103 SER 103 103 103 SER SER D . n 
D 1 104 GLU 104 104 104 GLU GLU D . n 
D 1 105 HIS 105 105 105 HIS HIS D . n 
D 1 106 THR 106 106 106 THR THR D . n 
D 1 107 VAL 107 107 107 VAL VAL D . n 
D 1 108 SER 108 108 108 SER SER D . n 
D 1 109 GLY 109 109 109 GLY GLY D . n 
D 1 110 GLN 110 110 110 GLN GLN D . n 
D 1 111 HIS 111 111 111 HIS HIS D . n 
D 1 112 PHE 112 112 112 PHE PHE D . n 
D 1 113 ALA 113 113 113 ALA ALA D . n 
D 1 114 ALA 114 114 114 ALA ALA D . n 
D 1 115 GLU 115 115 115 GLU GLU D . n 
D 1 116 LEU 116 116 116 LEU LEU D . n 
D 1 117 HIS 117 117 117 HIS HIS D . n 
D 1 118 ILE 118 118 118 ILE ILE D . n 
D 1 119 VAL 119 119 119 VAL VAL D . n 
D 1 120 HIS 120 120 120 HIS HIS D . n 
D 1 121 TYR 121 121 121 TYR TYR D . n 
D 1 122 ASN 122 122 122 ASN ASN D . n 
D 1 123 SER 123 123 123 SER SER D . n 
D 1 124 ASP 124 124 124 ASP ASP D . n 
D 1 125 LEU 125 125 125 LEU LEU D . n 
D 1 126 TYR 126 126 126 TYR TYR D . n 
D 1 127 PRO 127 127 127 PRO PRO D . n 
D 1 128 ASP 128 128 128 ASP ASP D . n 
D 1 129 ALA 129 129 129 ALA ALA D . n 
D 1 130 SER 130 130 130 SER SER D . n 
D 1 131 THR 131 131 131 THR THR D . n 
D 1 132 ALA 132 132 132 ALA ALA D . n 
D 1 133 SER 133 133 133 SER SER D . n 
D 1 134 ASN 134 134 134 ASN ASN D . n 
D 1 135 LYS 135 135 135 LYS LYS D . n 
D 1 136 SER 136 136 136 SER SER D . n 
D 1 137 GLU 137 137 137 GLU GLU D . n 
D 1 138 GLY 138 138 138 GLY GLY D . n 
D 1 139 LEU 139 139 139 LEU LEU D . n 
D 1 140 ALA 140 140 140 ALA ALA D . n 
D 1 141 VAL 141 141 141 VAL VAL D . n 
D 1 142 LEU 142 142 142 LEU LEU D . n 
D 1 143 ALA 143 143 143 ALA ALA D . n 
D 1 144 VAL 144 144 144 VAL VAL D . n 
D 1 145 LEU 145 145 145 LEU LEU D . n 
D 1 146 ILE 146 146 146 ILE ILE D . n 
D 1 147 GLU 147 147 147 GLU GLU D . n 
D 1 148 MET 148 148 148 MET MET D . n 
D 1 149 GLY 149 149 149 GLY GLY D . n 
D 1 150 SER 150 150 150 SER SER D . n 
D 1 151 PHE 151 151 151 PHE PHE D . n 
D 1 152 ASN 152 152 152 ASN ASN D . n 
D 1 153 PRO 153 153 153 PRO PRO D . n 
D 1 154 SER 154 154 154 SER SER D . n 
D 1 155 TYR 155 155 155 TYR TYR D . n 
D 1 156 ASP 156 156 156 ASP ASP D . n 
D 1 157 LYS 157 157 157 LYS LYS D . n 
D 1 158 ILE 158 158 158 ILE ILE D . n 
D 1 159 PHE 159 159 159 PHE PHE D . n 
D 1 160 SER 160 160 160 SER SER D . n 
D 1 161 HIS 161 161 161 HIS HIS D . n 
D 1 162 LEU 162 162 162 LEU LEU D . n 
D 1 163 GLN 163 163 163 GLN GLN D . n 
D 1 164 HIS 164 164 164 HIS HIS D . n 
D 1 165 VAL 165 165 165 VAL VAL D . n 
D 1 166 LYS 166 166 166 LYS LYS D . n 
D 1 167 TYR 167 167 167 TYR TYR D . n 
D 1 168 LYS 168 168 168 LYS LYS D . n 
D 1 169 GLY 169 169 169 GLY GLY D . n 
D 1 170 GLN 170 170 170 GLN GLN D . n 
D 1 171 GLU 171 171 171 GLU GLU D . n 
D 1 172 ALA 172 172 172 ALA ALA D . n 
D 1 173 PHE 173 173 173 PHE PHE D . n 
D 1 174 VAL 174 174 174 VAL VAL D . n 
D 1 175 PRO 175 175 175 PRO PRO D . n 
D 1 176 GLY 176 176 176 GLY GLY D . n 
D 1 177 PHE 177 177 177 PHE PHE D . n 
D 1 178 ASN 178 178 178 ASN ASN D . n 
D 1 179 ILE 179 179 179 ILE ILE D . n 
D 1 180 GLU 180 180 180 GLU GLU D . n 
D 1 181 GLU 181 181 181 GLU GLU D . n 
D 1 182 LEU 182 182 182 LEU LEU D . n 
D 1 183 LEU 183 183 183 LEU LEU D . n 
D 1 184 PRO 184 184 184 PRO PRO D . n 
D 1 185 GLU 185 185 185 GLU GLU D . n 
D 1 186 ARG 186 186 186 ARG ARG D . n 
D 1 187 THR 187 187 187 THR THR D . n 
D 1 188 ALA 188 188 188 ALA ALA D . n 
D 1 189 GLU 189 189 189 GLU GLU D . n 
D 1 190 TYR 190 190 190 TYR TYR D . n 
D 1 191 TYR 191 191 191 TYR TYR D . n 
D 1 192 ARG 192 192 192 ARG ARG D . n 
D 1 193 TYR 193 193 193 TYR TYR D . n 
D 1 194 ARG 194 194 194 ARG ARG D . n 
D 1 195 GLY 195 195 195 GLY GLY D . n 
D 1 196 SER 196 196 196 SER SER D . n 
D 1 197 LEU 197 197 197 LEU LEU D . n 
D 1 198 THR 198 198 198 THR THR D . n 
D 1 199 THR 199 199 199 THR THR D . n 
D 1 200 PRO 200 200 200 PRO PRO D . n 
D 1 201 PRO 201 201 201 PRO PRO D . n 
D 1 202 CYS 202 202 202 CYS CYS D . n 
D 1 203 ASN 203 203 203 ASN ASN D . n 
D 1 204 PRO 204 204 204 PRO PRO D . n 
D 1 205 THR 205 205 205 THR THR D . n 
D 1 206 VAL 206 206 206 VAL VAL D . n 
D 1 207 LEU 207 207 207 LEU LEU D . n 
D 1 208 TRP 208 208 208 TRP TRP D . n 
D 1 209 THR 209 209 209 THR THR D . n 
D 1 210 VAL 210 210 210 VAL VAL D . n 
D 1 211 PHE 211 211 211 PHE PHE D . n 
D 1 212 ARG 212 212 212 ARG ARG D . n 
D 1 213 ASN 213 213 213 ASN ASN D . n 
D 1 214 PRO 214 214 214 PRO PRO D . n 
D 1 215 VAL 215 215 215 VAL VAL D . n 
D 1 216 GLN 216 216 216 GLN GLN D . n 
D 1 217 ILE 217 217 217 ILE ILE D . n 
D 1 218 SER 218 218 218 SER SER D . n 
D 1 219 GLN 219 219 219 GLN GLN D . n 
D 1 220 GLU 220 220 220 GLU GLU D . n 
D 1 221 GLN 221 221 221 GLN GLN D . n 
D 1 222 LEU 222 222 222 LEU LEU D . n 
D 1 223 LEU 223 223 223 LEU LEU D . n 
D 1 224 ALA 224 224 224 ALA ALA D . n 
D 1 225 LEU 225 225 225 LEU LEU D . n 
D 1 226 GLU 226 226 226 GLU GLU D . n 
D 1 227 THR 227 227 227 THR THR D . n 
D 1 228 ALA 228 228 228 ALA ALA D . n 
D 1 229 LEU 229 229 229 LEU LEU D . n 
D 1 230 TYR 230 230 230 TYR TYR D . n 
D 1 231 CYS 231 231 231 CYS CYS D . n 
D 1 232 THR 232 232 232 THR THR D . n 
D 1 233 HIS 233 233 233 HIS HIS D . n 
D 1 234 MET 234 234 234 MET MET D . n 
D 1 235 ASP 235 235 235 ASP ASP D . n 
D 1 236 ASP 236 236 236 ASP ASP D . n 
D 1 237 PRO 237 237 237 PRO PRO D . n 
D 1 238 SER 238 238 238 SER SER D . n 
D 1 239 PRO 239 239 239 PRO PRO D . n 
D 1 240 ARG 240 240 240 ARG ARG D . n 
D 1 241 GLU 241 241 241 GLU GLU D . n 
D 1 242 MET 242 242 242 MET MET D . n 
D 1 243 ILE 243 243 243 ILE ILE D . n 
D 1 244 ASN 244 244 244 ASN ASN D . n 
D 1 245 ASN 245 245 245 ASN ASN D . n 
D 1 246 PHE 246 246 246 PHE PHE D . n 
D 1 247 ARG 247 247 247 ARG ARG D . n 
D 1 248 GLN 248 248 248 GLN GLN D . n 
D 1 249 VAL 249 249 249 VAL VAL D . n 
D 1 250 GLN 250 250 250 GLN GLN D . n 
D 1 251 LYS 251 251 251 LYS LYS D . n 
D 1 252 PHE 252 252 252 PHE PHE D . n 
D 1 253 ASP 253 253 253 ASP ASP D . n 
D 1 254 GLU 254 254 254 GLU GLU D . n 
D 1 255 ARG 255 255 255 ARG ARG D . n 
D 1 256 LEU 256 256 256 LEU LEU D . n 
D 1 257 VAL 257 257 257 VAL VAL D . n 
D 1 258 TYR 258 258 258 TYR TYR D . n 
D 1 259 THR 259 259 259 THR THR D . n 
D 1 260 SER 260 260 260 SER SER D . n 
D 1 261 PHE 261 261 261 PHE PHE D . n 
D 1 262 SER 262 262 262 SER SER D . n 
D 1 263 GLN 263 263 ?   ?   ?   D . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 2 ZN  1   301 1    ZN  ZN  A . 
F 3 6Z9 1   302 1    6Z9 VD3 A . 
G 2 ZN  1   301 2    ZN  ZN  B . 
H 3 6Z9 1   302 2    6Z9 VD3 B . 
I 2 ZN  1   301 3    ZN  ZN  C . 
J 3 6Z9 1   302 3    6Z9 VD3 C . 
K 2 ZN  1   301 4    ZN  ZN  D . 
L 3 6Z9 1   302 4    6Z9 VD3 D . 
M 4 HOH 1   401 586  HOH HOH A . 
M 4 HOH 2   402 1010 HOH HOH A . 
M 4 HOH 3   403 733  HOH HOH A . 
M 4 HOH 4   404 415  HOH HOH A . 
M 4 HOH 5   405 827  HOH HOH A . 
M 4 HOH 6   406 1025 HOH HOH A . 
M 4 HOH 7   407 495  HOH HOH A . 
M 4 HOH 8   408 493  HOH HOH A . 
M 4 HOH 9   409 913  HOH HOH A . 
M 4 HOH 10  410 409  HOH HOH A . 
M 4 HOH 11  411 1030 HOH HOH A . 
M 4 HOH 12  412 509  HOH HOH A . 
M 4 HOH 13  413 864  HOH HOH A . 
M 4 HOH 14  414 1068 HOH HOH A . 
M 4 HOH 15  415 318  HOH HOH A . 
M 4 HOH 16  416 73   HOH HOH A . 
M 4 HOH 17  417 37   HOH HOH A . 
M 4 HOH 18  418 1042 HOH HOH A . 
M 4 HOH 19  419 1162 HOH HOH A . 
M 4 HOH 20  420 1024 HOH HOH A . 
M 4 HOH 21  421 889  HOH HOH A . 
M 4 HOH 22  422 396  HOH HOH A . 
M 4 HOH 23  423 432  HOH HOH A . 
M 4 HOH 24  424 139  HOH HOH A . 
M 4 HOH 25  425 308  HOH HOH A . 
M 4 HOH 26  426 303  HOH HOH A . 
M 4 HOH 27  427 75   HOH HOH A . 
M 4 HOH 28  428 572  HOH HOH A . 
M 4 HOH 29  429 701  HOH HOH A . 
M 4 HOH 30  430 1064 HOH HOH A . 
M 4 HOH 31  431 463  HOH HOH A . 
M 4 HOH 32  432 691  HOH HOH A . 
M 4 HOH 33  433 274  HOH HOH A . 
M 4 HOH 34  434 923  HOH HOH A . 
M 4 HOH 35  435 272  HOH HOH A . 
M 4 HOH 36  436 675  HOH HOH A . 
M 4 HOH 37  437 945  HOH HOH A . 
M 4 HOH 38  438 539  HOH HOH A . 
M 4 HOH 39  439 150  HOH HOH A . 
M 4 HOH 40  440 260  HOH HOH A . 
M 4 HOH 41  441 480  HOH HOH A . 
M 4 HOH 42  442 38   HOH HOH A . 
M 4 HOH 43  443 822  HOH HOH A . 
M 4 HOH 44  444 845  HOH HOH A . 
M 4 HOH 45  445 375  HOH HOH A . 
M 4 HOH 46  446 855  HOH HOH A . 
M 4 HOH 47  447 352  HOH HOH A . 
M 4 HOH 48  448 442  HOH HOH A . 
M 4 HOH 49  449 988  HOH HOH A . 
M 4 HOH 50  450 199  HOH HOH A . 
M 4 HOH 51  451 816  HOH HOH A . 
M 4 HOH 52  452 24   HOH HOH A . 
M 4 HOH 53  453 315  HOH HOH A . 
M 4 HOH 54  454 290  HOH HOH A . 
M 4 HOH 55  455 510  HOH HOH A . 
M 4 HOH 56  456 420  HOH HOH A . 
M 4 HOH 57  457 171  HOH HOH A . 
M 4 HOH 58  458 135  HOH HOH A . 
M 4 HOH 59  459 60   HOH HOH A . 
M 4 HOH 60  460 460  HOH HOH A . 
M 4 HOH 61  461 388  HOH HOH A . 
M 4 HOH 62  462 807  HOH HOH A . 
M 4 HOH 63  463 522  HOH HOH A . 
M 4 HOH 64  464 226  HOH HOH A . 
M 4 HOH 65  465 455  HOH HOH A . 
M 4 HOH 66  466 398  HOH HOH A . 
M 4 HOH 67  467 214  HOH HOH A . 
M 4 HOH 68  468 486  HOH HOH A . 
M 4 HOH 69  469 555  HOH HOH A . 
M 4 HOH 70  470 9    HOH HOH A . 
M 4 HOH 71  471 32   HOH HOH A . 
M 4 HOH 72  472 662  HOH HOH A . 
M 4 HOH 73  473 376  HOH HOH A . 
M 4 HOH 74  474 568  HOH HOH A . 
M 4 HOH 75  475 414  HOH HOH A . 
M 4 HOH 76  476 45   HOH HOH A . 
M 4 HOH 77  477 1056 HOH HOH A . 
M 4 HOH 78  478 121  HOH HOH A . 
M 4 HOH 79  479 116  HOH HOH A . 
M 4 HOH 80  480 232  HOH HOH A . 
M 4 HOH 81  481 196  HOH HOH A . 
M 4 HOH 82  482 865  HOH HOH A . 
M 4 HOH 83  483 292  HOH HOH A . 
M 4 HOH 84  484 1033 HOH HOH A . 
M 4 HOH 85  485 540  HOH HOH A . 
M 4 HOH 86  486 598  HOH HOH A . 
M 4 HOH 87  487 42   HOH HOH A . 
M 4 HOH 88  488 676  HOH HOH A . 
M 4 HOH 89  489 329  HOH HOH A . 
M 4 HOH 90  490 349  HOH HOH A . 
M 4 HOH 91  491 365  HOH HOH A . 
M 4 HOH 92  492 322  HOH HOH A . 
M 4 HOH 93  493 389  HOH HOH A . 
M 4 HOH 94  494 118  HOH HOH A . 
M 4 HOH 95  495 526  HOH HOH A . 
M 4 HOH 96  496 488  HOH HOH A . 
M 4 HOH 97  497 49   HOH HOH A . 
M 4 HOH 98  498 268  HOH HOH A . 
M 4 HOH 99  499 271  HOH HOH A . 
M 4 HOH 100 500 899  HOH HOH A . 
M 4 HOH 101 501 12   HOH HOH A . 
M 4 HOH 102 502 106  HOH HOH A . 
M 4 HOH 103 503 1046 HOH HOH A . 
M 4 HOH 104 504 667  HOH HOH A . 
M 4 HOH 105 505 74   HOH HOH A . 
M 4 HOH 106 506 417  HOH HOH A . 
M 4 HOH 107 507 26   HOH HOH A . 
M 4 HOH 108 508 881  HOH HOH A . 
M 4 HOH 109 509 487  HOH HOH A . 
M 4 HOH 110 510 1034 HOH HOH A . 
M 4 HOH 111 511 147  HOH HOH A . 
M 4 HOH 112 512 402  HOH HOH A . 
M 4 HOH 113 513 428  HOH HOH A . 
M 4 HOH 114 514 496  HOH HOH A . 
M 4 HOH 115 515 569  HOH HOH A . 
M 4 HOH 116 516 34   HOH HOH A . 
M 4 HOH 117 517 111  HOH HOH A . 
M 4 HOH 118 518 27   HOH HOH A . 
M 4 HOH 119 519 490  HOH HOH A . 
M 4 HOH 120 520 341  HOH HOH A . 
M 4 HOH 121 521 1066 HOH HOH A . 
M 4 HOH 122 522 287  HOH HOH A . 
M 4 HOH 123 523 861  HOH HOH A . 
M 4 HOH 124 524 167  HOH HOH A . 
M 4 HOH 125 525 1031 HOH HOH A . 
M 4 HOH 126 526 627  HOH HOH A . 
M 4 HOH 127 527 343  HOH HOH A . 
M 4 HOH 128 528 51   HOH HOH A . 
M 4 HOH 129 529 370  HOH HOH A . 
M 4 HOH 130 530 367  HOH HOH A . 
M 4 HOH 131 531 350  HOH HOH A . 
M 4 HOH 132 532 1000 HOH HOH A . 
M 4 HOH 133 533 665  HOH HOH A . 
M 4 HOH 134 534 25   HOH HOH A . 
M 4 HOH 135 535 661  HOH HOH A . 
M 4 HOH 136 536 1036 HOH HOH A . 
M 4 HOH 137 537 39   HOH HOH A . 
M 4 HOH 138 538 184  HOH HOH A . 
M 4 HOH 139 539 813  HOH HOH A . 
M 4 HOH 140 540 220  HOH HOH A . 
M 4 HOH 141 541 795  HOH HOH A . 
M 4 HOH 142 542 521  HOH HOH A . 
M 4 HOH 143 543 590  HOH HOH A . 
M 4 HOH 144 544 302  HOH HOH A . 
M 4 HOH 145 545 891  HOH HOH A . 
M 4 HOH 146 546 82   HOH HOH A . 
M 4 HOH 147 547 249  HOH HOH A . 
M 4 HOH 148 548 1039 HOH HOH A . 
M 4 HOH 149 549 941  HOH HOH A . 
M 4 HOH 150 550 1181 HOH HOH A . 
M 4 HOH 151 551 28   HOH HOH A . 
M 4 HOH 152 552 961  HOH HOH A . 
M 4 HOH 153 553 819  HOH HOH A . 
M 4 HOH 154 554 689  HOH HOH A . 
M 4 HOH 155 555 937  HOH HOH A . 
M 4 HOH 156 556 932  HOH HOH A . 
M 4 HOH 157 557 238  HOH HOH A . 
M 4 HOH 158 558 231  HOH HOH A . 
M 4 HOH 159 559 145  HOH HOH A . 
M 4 HOH 160 560 505  HOH HOH A . 
M 4 HOH 161 561 175  HOH HOH A . 
M 4 HOH 162 562 44   HOH HOH A . 
M 4 HOH 163 563 227  HOH HOH A . 
M 4 HOH 164 564 863  HOH HOH A . 
M 4 HOH 165 565 660  HOH HOH A . 
M 4 HOH 166 566 416  HOH HOH A . 
M 4 HOH 167 567 930  HOH HOH A . 
M 4 HOH 168 568 1115 HOH HOH A . 
M 4 HOH 169 569 464  HOH HOH A . 
M 4 HOH 170 570 814  HOH HOH A . 
M 4 HOH 171 571 294  HOH HOH A . 
M 4 HOH 172 572 772  HOH HOH A . 
M 4 HOH 173 573 408  HOH HOH A . 
M 4 HOH 174 574 425  HOH HOH A . 
M 4 HOH 175 575 1028 HOH HOH A . 
M 4 HOH 176 576 1043 HOH HOH A . 
M 4 HOH 177 577 189  HOH HOH A . 
M 4 HOH 178 578 217  HOH HOH A . 
M 4 HOH 179 579 440  HOH HOH A . 
M 4 HOH 180 580 608  HOH HOH A . 
M 4 HOH 181 581 846  HOH HOH A . 
M 4 HOH 182 582 1007 HOH HOH A . 
M 4 HOH 183 583 1158 HOH HOH A . 
M 4 HOH 184 584 186  HOH HOH A . 
M 4 HOH 185 585 499  HOH HOH A . 
M 4 HOH 186 586 1037 HOH HOH A . 
M 4 HOH 187 587 337  HOH HOH A . 
M 4 HOH 188 588 261  HOH HOH A . 
M 4 HOH 189 589 473  HOH HOH A . 
M 4 HOH 190 590 663  HOH HOH A . 
M 4 HOH 191 591 671  HOH HOH A . 
M 4 HOH 192 592 808  HOH HOH A . 
M 4 HOH 193 593 1044 HOH HOH A . 
M 4 HOH 194 594 876  HOH HOH A . 
M 4 HOH 195 595 634  HOH HOH A . 
M 4 HOH 196 596 483  HOH HOH A . 
M 4 HOH 197 597 382  HOH HOH A . 
M 4 HOH 198 598 334  HOH HOH A . 
M 4 HOH 199 599 1166 HOH HOH A . 
M 4 HOH 200 600 423  HOH HOH A . 
M 4 HOH 201 601 117  HOH HOH A . 
M 4 HOH 202 602 1038 HOH HOH A . 
M 4 HOH 203 603 401  HOH HOH A . 
M 4 HOH 204 604 355  HOH HOH A . 
M 4 HOH 205 605 576  HOH HOH A . 
M 4 HOH 206 606 1054 HOH HOH A . 
M 4 HOH 207 607 194  HOH HOH A . 
M 4 HOH 208 608 773  HOH HOH A . 
M 4 HOH 209 609 434  HOH HOH A . 
M 4 HOH 210 610 810  HOH HOH A . 
M 4 HOH 211 611 847  HOH HOH A . 
M 4 HOH 212 612 542  HOH HOH A . 
M 4 HOH 213 613 1029 HOH HOH A . 
M 4 HOH 214 614 1147 HOH HOH A . 
M 4 HOH 215 615 1063 HOH HOH A . 
M 4 HOH 216 616 1057 HOH HOH A . 
M 4 HOH 217 617 1167 HOH HOH A . 
M 4 HOH 218 618 1055 HOH HOH A . 
M 4 HOH 219 619 1009 HOH HOH A . 
M 4 HOH 220 620 1060 HOH HOH A . 
M 4 HOH 221 621 1127 HOH HOH A . 
M 4 HOH 222 622 851  HOH HOH A . 
M 4 HOH 223 623 970  HOH HOH A . 
M 4 HOH 224 624 924  HOH HOH A . 
M 4 HOH 225 625 938  HOH HOH A . 
M 4 HOH 226 626 1070 HOH HOH A . 
M 4 HOH 227 627 1099 HOH HOH A . 
M 4 HOH 228 628 1047 HOH HOH A . 
M 4 HOH 229 629 715  HOH HOH A . 
M 4 HOH 230 630 1041 HOH HOH A . 
M 4 HOH 231 631 703  HOH HOH A . 
M 4 HOH 232 632 942  HOH HOH A . 
M 4 HOH 233 633 766  HOH HOH A . 
M 4 HOH 234 634 1032 HOH HOH A . 
M 4 HOH 235 635 600  HOH HOH A . 
M 4 HOH 236 636 1040 HOH HOH A . 
M 4 HOH 237 637 725  HOH HOH A . 
M 4 HOH 238 638 1160 HOH HOH A . 
M 4 HOH 239 639 707  HOH HOH A . 
M 4 HOH 240 640 1159 HOH HOH A . 
M 4 HOH 241 641 767  HOH HOH A . 
M 4 HOH 242 642 836  HOH HOH A . 
M 4 HOH 243 643 1182 HOH HOH A . 
M 4 HOH 244 644 1069 HOH HOH A . 
M 4 HOH 245 645 604  HOH HOH A . 
M 4 HOH 246 646 293  HOH HOH A . 
M 4 HOH 247 647 1048 HOH HOH A . 
M 4 HOH 248 648 1008 HOH HOH A . 
M 4 HOH 249 649 826  HOH HOH A . 
M 4 HOH 250 650 1035 HOH HOH A . 
M 4 HOH 251 651 1177 HOH HOH A . 
M 4 HOH 252 652 1152 HOH HOH A . 
M 4 HOH 253 653 717  HOH HOH A . 
M 4 HOH 254 654 791  HOH HOH A . 
M 4 HOH 255 655 898  HOH HOH A . 
M 4 HOH 256 656 892  HOH HOH A . 
M 4 HOH 257 657 637  HOH HOH A . 
M 4 HOH 258 658 354  HOH HOH A . 
M 4 HOH 259 659 843  HOH HOH A . 
M 4 HOH 260 660 1059 HOH HOH A . 
M 4 HOH 261 661 966  HOH HOH A . 
M 4 HOH 262 662 776  HOH HOH A . 
M 4 HOH 263 663 1164 HOH HOH A . 
M 4 HOH 264 664 809  HOH HOH A . 
M 4 HOH 265 665 991  HOH HOH A . 
M 4 HOH 266 666 1026 HOH HOH A . 
M 4 HOH 267 667 973  HOH HOH A . 
M 4 HOH 268 668 1053 HOH HOH A . 
M 4 HOH 269 669 636  HOH HOH A . 
M 4 HOH 270 670 1027 HOH HOH A . 
M 4 HOH 271 671 980  HOH HOH A . 
M 4 HOH 272 672 1062 HOH HOH A . 
M 4 HOH 273 673 459  HOH HOH A . 
M 4 HOH 274 674 630  HOH HOH A . 
M 4 HOH 275 675 1165 HOH HOH A . 
M 4 HOH 276 676 677  HOH HOH A . 
M 4 HOH 277 677 548  HOH HOH A . 
M 4 HOH 278 678 878  HOH HOH A . 
M 4 HOH 279 679 475  HOH HOH A . 
M 4 HOH 280 680 828  HOH HOH A . 
M 4 HOH 281 681 690  HOH HOH A . 
M 4 HOH 282 682 1184 HOH HOH A . 
M 4 HOH 283 683 1050 HOH HOH A . 
M 4 HOH 284 684 755  HOH HOH A . 
M 4 HOH 285 685 922  HOH HOH A . 
M 4 HOH 286 686 1163 HOH HOH A . 
M 4 HOH 287 687 963  HOH HOH A . 
M 4 HOH 288 688 1183 HOH HOH A . 
M 4 HOH 289 689 731  HOH HOH A . 
M 4 HOH 290 690 928  HOH HOH A . 
M 4 HOH 291 691 805  HOH HOH A . 
M 4 HOH 292 692 1058 HOH HOH A . 
N 4 HOH 1   401 909  HOH HOH B . 
N 4 HOH 2   402 792  HOH HOH B . 
N 4 HOH 3   403 1051 HOH HOH B . 
N 4 HOH 4   404 474  HOH HOH B . 
N 4 HOH 5   405 166  HOH HOH B . 
N 4 HOH 6   406 1005 HOH HOH B . 
N 4 HOH 7   407 507  HOH HOH B . 
N 4 HOH 8   408 222  HOH HOH B . 
N 4 HOH 9   409 916  HOH HOH B . 
N 4 HOH 10  410 657  HOH HOH B . 
N 4 HOH 11  411 1012 HOH HOH B . 
N 4 HOH 12  412 1075 HOH HOH B . 
N 4 HOH 13  413 50   HOH HOH B . 
N 4 HOH 14  414 477  HOH HOH B . 
N 4 HOH 15  415 1171 HOH HOH B . 
N 4 HOH 16  416 1079 HOH HOH B . 
N 4 HOH 17  417 153  HOH HOH B . 
N 4 HOH 18  418 597  HOH HOH B . 
N 4 HOH 19  419 484  HOH HOH B . 
N 4 HOH 20  420 615  HOH HOH B . 
N 4 HOH 21  421 1013 HOH HOH B . 
N 4 HOH 22  422 903  HOH HOH B . 
N 4 HOH 23  423 765  HOH HOH B . 
N 4 HOH 24  424 385  HOH HOH B . 
N 4 HOH 25  425 380  HOH HOH B . 
N 4 HOH 26  426 1168 HOH HOH B . 
N 4 HOH 27  427 688  HOH HOH B . 
N 4 HOH 28  428 70   HOH HOH B . 
N 4 HOH 29  429 363  HOH HOH B . 
N 4 HOH 30  430 999  HOH HOH B . 
N 4 HOH 31  431 239  HOH HOH B . 
N 4 HOH 32  432 124  HOH HOH B . 
N 4 HOH 33  433 750  HOH HOH B . 
N 4 HOH 34  434 833  HOH HOH B . 
N 4 HOH 35  435 925  HOH HOH B . 
N 4 HOH 36  436 394  HOH HOH B . 
N 4 HOH 37  437 1071 HOH HOH B . 
N 4 HOH 38  438 1077 HOH HOH B . 
N 4 HOH 39  439 419  HOH HOH B . 
N 4 HOH 40  440 1093 HOH HOH B . 
N 4 HOH 41  441 443  HOH HOH B . 
N 4 HOH 42  442 880  HOH HOH B . 
N 4 HOH 43  443 130  HOH HOH B . 
N 4 HOH 44  444 229  HOH HOH B . 
N 4 HOH 45  445 100  HOH HOH B . 
N 4 HOH 46  446 364  HOH HOH B . 
N 4 HOH 47  447 656  HOH HOH B . 
N 4 HOH 48  448 709  HOH HOH B . 
N 4 HOH 49  449 573  HOH HOH B . 
N 4 HOH 50  450 328  HOH HOH B . 
N 4 HOH 51  451 971  HOH HOH B . 
N 4 HOH 52  452 1170 HOH HOH B . 
N 4 HOH 53  453 250  HOH HOH B . 
N 4 HOH 54  454 391  HOH HOH B . 
N 4 HOH 55  455 89   HOH HOH B . 
N 4 HOH 56  456 939  HOH HOH B . 
N 4 HOH 57  457 872  HOH HOH B . 
N 4 HOH 58  458 252  HOH HOH B . 
N 4 HOH 59  459 381  HOH HOH B . 
N 4 HOH 60  460 155  HOH HOH B . 
N 4 HOH 61  461 22   HOH HOH B . 
N 4 HOH 62  462 606  HOH HOH B . 
N 4 HOH 63  463 181  HOH HOH B . 
N 4 HOH 64  464 18   HOH HOH B . 
N 4 HOH 65  465 84   HOH HOH B . 
N 4 HOH 66  466 700  HOH HOH B . 
N 4 HOH 67  467 686  HOH HOH B . 
N 4 HOH 68  468 151  HOH HOH B . 
N 4 HOH 69  469 361  HOH HOH B . 
N 4 HOH 70  470 279  HOH HOH B . 
N 4 HOH 71  471 502  HOH HOH B . 
N 4 HOH 72  472 90   HOH HOH B . 
N 4 HOH 73  473 366  HOH HOH B . 
N 4 HOH 74  474 170  HOH HOH B . 
N 4 HOH 75  475 853  HOH HOH B . 
N 4 HOH 76  476 777  HOH HOH B . 
N 4 HOH 77  477 320  HOH HOH B . 
N 4 HOH 78  478 36   HOH HOH B . 
N 4 HOH 79  479 639  HOH HOH B . 
N 4 HOH 80  480 360  HOH HOH B . 
N 4 HOH 81  481 625  HOH HOH B . 
N 4 HOH 82  482 452  HOH HOH B . 
N 4 HOH 83  483 247  HOH HOH B . 
N 4 HOH 84  484 86   HOH HOH B . 
N 4 HOH 85  485 503  HOH HOH B . 
N 4 HOH 86  486 491  HOH HOH B . 
N 4 HOH 87  487 746  HOH HOH B . 
N 4 HOH 88  488 683  HOH HOH B . 
N 4 HOH 89  489 953  HOH HOH B . 
N 4 HOH 90  490 96   HOH HOH B . 
N 4 HOH 91  491 159  HOH HOH B . 
N 4 HOH 92  492 859  HOH HOH B . 
N 4 HOH 93  493 105  HOH HOH B . 
N 4 HOH 94  494 92   HOH HOH B . 
N 4 HOH 95  495 448  HOH HOH B . 
N 4 HOH 96  496 125  HOH HOH B . 
N 4 HOH 97  497 841  HOH HOH B . 
N 4 HOH 98  498 870  HOH HOH B . 
N 4 HOH 99  499 594  HOH HOH B . 
N 4 HOH 100 500 687  HOH HOH B . 
N 4 HOH 101 501 319  HOH HOH B . 
N 4 HOH 102 502 373  HOH HOH B . 
N 4 HOH 103 503 768  HOH HOH B . 
N 4 HOH 104 504 273  HOH HOH B . 
N 4 HOH 105 505 148  HOH HOH B . 
N 4 HOH 106 506 53   HOH HOH B . 
N 4 HOH 107 507 457  HOH HOH B . 
N 4 HOH 108 508 61   HOH HOH B . 
N 4 HOH 109 509 849  HOH HOH B . 
N 4 HOH 110 510 201  HOH HOH B . 
N 4 HOH 111 511 103  HOH HOH B . 
N 4 HOH 112 512 205  HOH HOH B . 
N 4 HOH 113 513 134  HOH HOH B . 
N 4 HOH 114 514 55   HOH HOH B . 
N 4 HOH 115 515 1076 HOH HOH B . 
N 4 HOH 116 516 137  HOH HOH B . 
N 4 HOH 117 517 563  HOH HOH B . 
N 4 HOH 118 518 426  HOH HOH B . 
N 4 HOH 119 519 110  HOH HOH B . 
N 4 HOH 120 520 482  HOH HOH B . 
N 4 HOH 121 521 1156 HOH HOH B . 
N 4 HOH 122 522 655  HOH HOH B . 
N 4 HOH 123 523 11   HOH HOH B . 
N 4 HOH 124 524 76   HOH HOH B . 
N 4 HOH 125 525 386  HOH HOH B . 
N 4 HOH 126 526 163  HOH HOH B . 
N 4 HOH 127 527 31   HOH HOH B . 
N 4 HOH 128 528 562  HOH HOH B . 
N 4 HOH 129 529 235  HOH HOH B . 
N 4 HOH 130 530 582  HOH HOH B . 
N 4 HOH 131 531 571  HOH HOH B . 
N 4 HOH 132 532 558  HOH HOH B . 
N 4 HOH 133 533 756  HOH HOH B . 
N 4 HOH 134 534 225  HOH HOH B . 
N 4 HOH 135 535 248  HOH HOH B . 
N 4 HOH 136 536 643  HOH HOH B . 
N 4 HOH 137 537 119  HOH HOH B . 
N 4 HOH 138 538 267  HOH HOH B . 
N 4 HOH 139 539 693  HOH HOH B . 
N 4 HOH 140 540 469  HOH HOH B . 
N 4 HOH 141 541 309  HOH HOH B . 
N 4 HOH 142 542 504  HOH HOH B . 
N 4 HOH 143 543 557  HOH HOH B . 
N 4 HOH 144 544 1140 HOH HOH B . 
N 4 HOH 145 545 387  HOH HOH B . 
N 4 HOH 146 546 745  HOH HOH B . 
N 4 HOH 147 547 8    HOH HOH B . 
N 4 HOH 148 548 559  HOH HOH B . 
N 4 HOH 149 549 114  HOH HOH B . 
N 4 HOH 150 550 520  HOH HOH B . 
N 4 HOH 151 551 78   HOH HOH B . 
N 4 HOH 152 552 779  HOH HOH B . 
N 4 HOH 153 553 193  HOH HOH B . 
N 4 HOH 154 554 371  HOH HOH B . 
N 4 HOH 155 555 197  HOH HOH B . 
N 4 HOH 156 556 842  HOH HOH B . 
N 4 HOH 157 557 769  HOH HOH B . 
N 4 HOH 158 558 257  HOH HOH B . 
N 4 HOH 159 559 868  HOH HOH B . 
N 4 HOH 160 560 10   HOH HOH B . 
N 4 HOH 161 561 921  HOH HOH B . 
N 4 HOH 162 562 265  HOH HOH B . 
N 4 HOH 163 563 161  HOH HOH B . 
N 4 HOH 164 564 1072 HOH HOH B . 
N 4 HOH 165 565 770  HOH HOH B . 
N 4 HOH 166 566 468  HOH HOH B . 
N 4 HOH 167 567 362  HOH HOH B . 
N 4 HOH 168 568 87   HOH HOH B . 
N 4 HOH 169 569 929  HOH HOH B . 
N 4 HOH 170 570 223  HOH HOH B . 
N 4 HOH 171 571 240  HOH HOH B . 
N 4 HOH 172 572 384  HOH HOH B . 
N 4 HOH 173 573 1073 HOH HOH B . 
N 4 HOH 174 574 1174 HOH HOH B . 
N 4 HOH 175 575 775  HOH HOH B . 
N 4 HOH 176 576 1169 HOH HOH B . 
N 4 HOH 177 577 258  HOH HOH B . 
N 4 HOH 178 578 177  HOH HOH B . 
N 4 HOH 179 579 259  HOH HOH B . 
N 4 HOH 180 580 95   HOH HOH B . 
N 4 HOH 181 581 128  HOH HOH B . 
N 4 HOH 182 582 305  HOH HOH B . 
N 4 HOH 183 583 244  HOH HOH B . 
N 4 HOH 184 584 956  HOH HOH B . 
N 4 HOH 185 585 311  HOH HOH B . 
N 4 HOH 186 586 753  HOH HOH B . 
N 4 HOH 187 587 534  HOH HOH B . 
N 4 HOH 188 588 357  HOH HOH B . 
N 4 HOH 189 589 584  HOH HOH B . 
N 4 HOH 190 590 905  HOH HOH B . 
N 4 HOH 191 591 943  HOH HOH B . 
N 4 HOH 192 592 72   HOH HOH B . 
N 4 HOH 193 593 1085 HOH HOH B . 
N 4 HOH 194 594 492  HOH HOH B . 
N 4 HOH 195 595 1011 HOH HOH B . 
N 4 HOH 196 596 1082 HOH HOH B . 
N 4 HOH 197 597 275  HOH HOH B . 
N 4 HOH 198 598 782  HOH HOH B . 
N 4 HOH 199 599 321  HOH HOH B . 
N 4 HOH 200 600 236  HOH HOH B . 
N 4 HOH 201 601 173  HOH HOH B . 
N 4 HOH 202 602 407  HOH HOH B . 
N 4 HOH 203 603 592  HOH HOH B . 
N 4 HOH 204 604 914  HOH HOH B . 
N 4 HOH 205 605 404  HOH HOH B . 
N 4 HOH 206 606 1089 HOH HOH B . 
N 4 HOH 207 607 207  HOH HOH B . 
N 4 HOH 208 608 1154 HOH HOH B . 
N 4 HOH 209 609 751  HOH HOH B . 
N 4 HOH 210 610 908  HOH HOH B . 
N 4 HOH 211 611 633  HOH HOH B . 
N 4 HOH 212 612 595  HOH HOH B . 
N 4 HOH 213 613 1049 HOH HOH B . 
N 4 HOH 214 614 531  HOH HOH B . 
N 4 HOH 215 615 256  HOH HOH B . 
N 4 HOH 216 616 210  HOH HOH B . 
N 4 HOH 217 617 122  HOH HOH B . 
N 4 HOH 218 618 882  HOH HOH B . 
N 4 HOH 219 619 497  HOH HOH B . 
N 4 HOH 220 620 1004 HOH HOH B . 
N 4 HOH 221 621 906  HOH HOH B . 
N 4 HOH 222 622 874  HOH HOH B . 
N 4 HOH 223 623 1014 HOH HOH B . 
N 4 HOH 224 624 288  HOH HOH B . 
N 4 HOH 225 625 747  HOH HOH B . 
N 4 HOH 226 626 1080 HOH HOH B . 
N 4 HOH 227 627 327  HOH HOH B . 
N 4 HOH 228 628 910  HOH HOH B . 
N 4 HOH 229 629 1084 HOH HOH B . 
N 4 HOH 230 630 1074 HOH HOH B . 
N 4 HOH 231 631 632  HOH HOH B . 
N 4 HOH 232 632 1090 HOH HOH B . 
N 4 HOH 233 633 1052 HOH HOH B . 
N 4 HOH 234 634 1180 HOH HOH B . 
N 4 HOH 235 635 787  HOH HOH B . 
N 4 HOH 236 636 619  HOH HOH B . 
N 4 HOH 237 637 1157 HOH HOH B . 
N 4 HOH 238 638 764  HOH HOH B . 
N 4 HOH 239 639 640  HOH HOH B . 
N 4 HOH 240 640 317  HOH HOH B . 
N 4 HOH 241 641 697  HOH HOH B . 
N 4 HOH 242 642 1178 HOH HOH B . 
N 4 HOH 243 643 877  HOH HOH B . 
N 4 HOH 244 644 711  HOH HOH B . 
N 4 HOH 245 645 977  HOH HOH B . 
N 4 HOH 246 646 672  HOH HOH B . 
N 4 HOH 247 647 1088 HOH HOH B . 
N 4 HOH 248 648 840  HOH HOH B . 
N 4 HOH 249 649 393  HOH HOH B . 
N 4 HOH 250 650 629  HOH HOH B . 
N 4 HOH 251 651 692  HOH HOH B . 
N 4 HOH 252 652 647  HOH HOH B . 
N 4 HOH 253 653 1083 HOH HOH B . 
N 4 HOH 254 654 476  HOH HOH B . 
N 4 HOH 255 655 721  HOH HOH B . 
N 4 HOH 256 656 732  HOH HOH B . 
N 4 HOH 257 657 958  HOH HOH B . 
N 4 HOH 258 658 997  HOH HOH B . 
N 4 HOH 259 659 786  HOH HOH B . 
N 4 HOH 260 660 1078 HOH HOH B . 
N 4 HOH 261 661 1092 HOH HOH B . 
N 4 HOH 262 662 296  HOH HOH B . 
N 4 HOH 263 663 976  HOH HOH B . 
N 4 HOH 264 664 856  HOH HOH B . 
N 4 HOH 265 665 325  HOH HOH B . 
N 4 HOH 266 666 735  HOH HOH B . 
N 4 HOH 267 667 785  HOH HOH B . 
N 4 HOH 268 668 724  HOH HOH B . 
N 4 HOH 269 669 344  HOH HOH B . 
N 4 HOH 270 670 348  HOH HOH B . 
N 4 HOH 271 671 740  HOH HOH B . 
N 4 HOH 272 672 716  HOH HOH B . 
N 4 HOH 273 673 587  HOH HOH B . 
N 4 HOH 274 674 830  HOH HOH B . 
N 4 HOH 275 675 335  HOH HOH B . 
N 4 HOH 276 676 723  HOH HOH B . 
N 4 HOH 277 677 1129 HOH HOH B . 
N 4 HOH 278 678 897  HOH HOH B . 
N 4 HOH 279 679 577  HOH HOH B . 
N 4 HOH 280 680 1081 HOH HOH B . 
N 4 HOH 281 681 1087 HOH HOH B . 
N 4 HOH 282 682 796  HOH HOH B . 
N 4 HOH 283 683 902  HOH HOH B . 
N 4 HOH 284 684 1155 HOH HOH B . 
N 4 HOH 285 685 722  HOH HOH B . 
N 4 HOH 286 686 624  HOH HOH B . 
N 4 HOH 287 687 757  HOH HOH B . 
N 4 HOH 288 688 762  HOH HOH B . 
N 4 HOH 289 689 524  HOH HOH B . 
N 4 HOH 290 690 901  HOH HOH B . 
N 4 HOH 291 691 378  HOH HOH B . 
N 4 HOH 292 692 399  HOH HOH B . 
N 4 HOH 293 693 506  HOH HOH B . 
N 4 HOH 294 694 1003 HOH HOH B . 
N 4 HOH 295 695 284  HOH HOH B . 
N 4 HOH 296 696 1123 HOH HOH B . 
N 4 HOH 297 697 788  HOH HOH B . 
N 4 HOH 298 698 871  HOH HOH B . 
N 4 HOH 299 699 719  HOH HOH B . 
N 4 HOH 300 700 714  HOH HOH B . 
N 4 HOH 301 701 356  HOH HOH B . 
N 4 HOH 302 702 737  HOH HOH B . 
N 4 HOH 303 703 738  HOH HOH B . 
N 4 HOH 304 704 972  HOH HOH B . 
N 4 HOH 305 705 825  HOH HOH B . 
N 4 HOH 306 706 1086 HOH HOH B . 
N 4 HOH 307 707 1161 HOH HOH B . 
O 4 HOH 1   401 98   HOH HOH C . 
O 4 HOH 2   402 1094 HOH HOH C . 
O 4 HOH 3   403 379  HOH HOH C . 
O 4 HOH 4   404 1016 HOH HOH C . 
O 4 HOH 5   405 936  HOH HOH C . 
O 4 HOH 6   406 678  HOH HOH C . 
O 4 HOH 7   407 596  HOH HOH C . 
O 4 HOH 8   408 1001 HOH HOH C . 
O 4 HOH 9   409 123  HOH HOH C . 
O 4 HOH 10  410 560  HOH HOH C . 
O 4 HOH 11  411 886  HOH HOH C . 
O 4 HOH 12  412 519  HOH HOH C . 
O 4 HOH 13  413 960  HOH HOH C . 
O 4 HOH 14  414 306  HOH HOH C . 
O 4 HOH 15  415 512  HOH HOH C . 
O 4 HOH 16  416 146  HOH HOH C . 
O 4 HOH 17  417 706  HOH HOH C . 
O 4 HOH 18  418 300  HOH HOH C . 
O 4 HOH 19  419 530  HOH HOH C . 
O 4 HOH 20  420 190  HOH HOH C . 
O 4 HOH 21  421 927  HOH HOH C . 
O 4 HOH 22  422 472  HOH HOH C . 
O 4 HOH 23  423 888  HOH HOH C . 
O 4 HOH 24  424 995  HOH HOH C . 
O 4 HOH 25  425 1109 HOH HOH C . 
O 4 HOH 26  426 611  HOH HOH C . 
O 4 HOH 27  427 1102 HOH HOH C . 
O 4 HOH 28  428 307  HOH HOH C . 
O 4 HOH 29  429 653  HOH HOH C . 
O 4 HOH 30  430 823  HOH HOH C . 
O 4 HOH 31  431 254  HOH HOH C . 
O 4 HOH 32  432 63   HOH HOH C . 
O 4 HOH 33  433 5    HOH HOH C . 
O 4 HOH 34  434 158  HOH HOH C . 
O 4 HOH 35  435 752  HOH HOH C . 
O 4 HOH 36  436 430  HOH HOH C . 
O 4 HOH 37  437 607  HOH HOH C . 
O 4 HOH 38  438 88   HOH HOH C . 
O 4 HOH 39  439 967  HOH HOH C . 
O 4 HOH 40  440 466  HOH HOH C . 
O 4 HOH 41  441 710  HOH HOH C . 
O 4 HOH 42  442 263  HOH HOH C . 
O 4 HOH 43  443 234  HOH HOH C . 
O 4 HOH 44  444 16   HOH HOH C . 
O 4 HOH 45  445 593  HOH HOH C . 
O 4 HOH 46  446 224  HOH HOH C . 
O 4 HOH 47  447 241  HOH HOH C . 
O 4 HOH 48  448 206  HOH HOH C . 
O 4 HOH 49  449 1112 HOH HOH C . 
O 4 HOH 50  450 213  HOH HOH C . 
O 4 HOH 51  451 85   HOH HOH C . 
O 4 HOH 52  452 351  HOH HOH C . 
O 4 HOH 53  453 203  HOH HOH C . 
O 4 HOH 54  454 30   HOH HOH C . 
O 4 HOH 55  455 237  HOH HOH C . 
O 4 HOH 56  456 188  HOH HOH C . 
O 4 HOH 57  457 113  HOH HOH C . 
O 4 HOH 58  458 340  HOH HOH C . 
O 4 HOH 59  459 246  HOH HOH C . 
O 4 HOH 60  460 982  HOH HOH C . 
O 4 HOH 61  461 297  HOH HOH C . 
O 4 HOH 62  462 7    HOH HOH C . 
O 4 HOH 63  463 156  HOH HOH C . 
O 4 HOH 64  464 467  HOH HOH C . 
O 4 HOH 65  465 628  HOH HOH C . 
O 4 HOH 66  466 525  HOH HOH C . 
O 4 HOH 67  467 783  HOH HOH C . 
O 4 HOH 68  468 216  HOH HOH C . 
O 4 HOH 69  469 286  HOH HOH C . 
O 4 HOH 70  470 831  HOH HOH C . 
O 4 HOH 71  471 893  HOH HOH C . 
O 4 HOH 72  472 174  HOH HOH C . 
O 4 HOH 73  473 141  HOH HOH C . 
O 4 HOH 74  474 968  HOH HOH C . 
O 4 HOH 75  475 758  HOH HOH C . 
O 4 HOH 76  476 685  HOH HOH C . 
O 4 HOH 77  477 218  HOH HOH C . 
O 4 HOH 78  478 992  HOH HOH C . 
O 4 HOH 79  479 202  HOH HOH C . 
O 4 HOH 80  480 48   HOH HOH C . 
O 4 HOH 81  481 94   HOH HOH C . 
O 4 HOH 82  482 245  HOH HOH C . 
O 4 HOH 83  483 1101 HOH HOH C . 
O 4 HOH 84  484 760  HOH HOH C . 
O 4 HOH 85  485 669  HOH HOH C . 
O 4 HOH 86  486 182  HOH HOH C . 
O 4 HOH 87  487 1110 HOH HOH C . 
O 4 HOH 88  488 429  HOH HOH C . 
O 4 HOH 89  489 917  HOH HOH C . 
O 4 HOH 90  490 209  HOH HOH C . 
O 4 HOH 91  491 178  HOH HOH C . 
O 4 HOH 92  492 485  HOH HOH C . 
O 4 HOH 93  493 518  HOH HOH C . 
O 4 HOH 94  494 299  HOH HOH C . 
O 4 HOH 95  495 377  HOH HOH C . 
O 4 HOH 96  496 802  HOH HOH C . 
O 4 HOH 97  497 896  HOH HOH C . 
O 4 HOH 98  498 852  HOH HOH C . 
O 4 HOH 99  499 1113 HOH HOH C . 
O 4 HOH 100 500 59   HOH HOH C . 
O 4 HOH 101 501 867  HOH HOH C . 
O 4 HOH 102 502 537  HOH HOH C . 
O 4 HOH 103 503 20   HOH HOH C . 
O 4 HOH 104 504 112  HOH HOH C . 
O 4 HOH 105 505 47   HOH HOH C . 
O 4 HOH 106 506 650  HOH HOH C . 
O 4 HOH 107 507 621  HOH HOH C . 
O 4 HOH 108 508 413  HOH HOH C . 
O 4 HOH 109 509 176  HOH HOH C . 
O 4 HOH 110 510 427  HOH HOH C . 
O 4 HOH 111 511 285  HOH HOH C . 
O 4 HOH 112 512 132  HOH HOH C . 
O 4 HOH 113 513 13   HOH HOH C . 
O 4 HOH 114 514 471  HOH HOH C . 
O 4 HOH 115 515 52   HOH HOH C . 
O 4 HOH 116 516 564  HOH HOH C . 
O 4 HOH 117 517 138  HOH HOH C . 
O 4 HOH 118 518 919  HOH HOH C . 
O 4 HOH 119 519 140  HOH HOH C . 
O 4 HOH 120 520 651  HOH HOH C . 
O 4 HOH 121 521 162  HOH HOH C . 
O 4 HOH 122 522 478  HOH HOH C . 
O 4 HOH 123 523 528  HOH HOH C . 
O 4 HOH 124 524 445  HOH HOH C . 
O 4 HOH 125 525 447  HOH HOH C . 
O 4 HOH 126 526 438  HOH HOH C . 
O 4 HOH 127 527 553  HOH HOH C . 
O 4 HOH 128 528 763  HOH HOH C . 
O 4 HOH 129 529 1    HOH HOH C . 
O 4 HOH 130 530 605  HOH HOH C . 
O 4 HOH 131 531 99   HOH HOH C . 
O 4 HOH 132 532 97   HOH HOH C . 
O 4 HOH 133 533 844  HOH HOH C . 
O 4 HOH 134 534 618  HOH HOH C . 
O 4 HOH 135 535 14   HOH HOH C . 
O 4 HOH 136 536 975  HOH HOH C . 
O 4 HOH 137 537 617  HOH HOH C . 
O 4 HOH 138 538 172  HOH HOH C . 
O 4 HOH 139 539 610  HOH HOH C . 
O 4 HOH 140 540 581  HOH HOH C . 
O 4 HOH 141 541 69   HOH HOH C . 
O 4 HOH 142 542 580  HOH HOH C . 
O 4 HOH 143 543 77   HOH HOH C . 
O 4 HOH 144 544 400  HOH HOH C . 
O 4 HOH 145 545 79   HOH HOH C . 
O 4 HOH 146 546 550  HOH HOH C . 
O 4 HOH 147 547 185  HOH HOH C . 
O 4 HOH 148 548 108  HOH HOH C . 
O 4 HOH 149 549 411  HOH HOH C . 
O 4 HOH 150 550 978  HOH HOH C . 
O 4 HOH 151 551 858  HOH HOH C . 
O 4 HOH 152 552 304  HOH HOH C . 
O 4 HOH 153 553 29   HOH HOH C . 
O 4 HOH 154 554 616  HOH HOH C . 
O 4 HOH 155 555 920  HOH HOH C . 
O 4 HOH 156 556 1097 HOH HOH C . 
O 4 HOH 157 557 695  HOH HOH C . 
O 4 HOH 158 558 208  HOH HOH C . 
O 4 HOH 159 559 838  HOH HOH C . 
O 4 HOH 160 560 981  HOH HOH C . 
O 4 HOH 161 561 64   HOH HOH C . 
O 4 HOH 162 562 556  HOH HOH C . 
O 4 HOH 163 563 869  HOH HOH C . 
O 4 HOH 164 564 481  HOH HOH C . 
O 4 HOH 165 565 1017 HOH HOH C . 
O 4 HOH 166 566 1096 HOH HOH C . 
O 4 HOH 167 567 784  HOH HOH C . 
O 4 HOH 168 568 835  HOH HOH C . 
O 4 HOH 169 569 228  HOH HOH C . 
O 4 HOH 170 570 622  HOH HOH C . 
O 4 HOH 171 571 187  HOH HOH C . 
O 4 HOH 172 572 397  HOH HOH C . 
O 4 HOH 173 573 601  HOH HOH C . 
O 4 HOH 174 574 127  HOH HOH C . 
O 4 HOH 175 575 345  HOH HOH C . 
O 4 HOH 176 576 133  HOH HOH C . 
O 4 HOH 177 577 554  HOH HOH C . 
O 4 HOH 178 578 696  HOH HOH C . 
O 4 HOH 179 579 233  HOH HOH C . 
O 4 HOH 180 580 312  HOH HOH C . 
O 4 HOH 181 581 574  HOH HOH C . 
O 4 HOH 182 582 959  HOH HOH C . 
O 4 HOH 183 583 862  HOH HOH C . 
O 4 HOH 184 584 529  HOH HOH C . 
O 4 HOH 185 585 433  HOH HOH C . 
O 4 HOH 186 586 638  HOH HOH C . 
O 4 HOH 187 587 1098 HOH HOH C . 
O 4 HOH 188 588 575  HOH HOH C . 
O 4 HOH 189 589 984  HOH HOH C . 
O 4 HOH 190 590 424  HOH HOH C . 
O 4 HOH 191 591 1045 HOH HOH C . 
O 4 HOH 192 592 289  HOH HOH C . 
O 4 HOH 193 593 324  HOH HOH C . 
O 4 HOH 194 594 1111 HOH HOH C . 
O 4 HOH 195 595 579  HOH HOH C . 
O 4 HOH 196 596 641  HOH HOH C . 
O 4 HOH 197 597 1103 HOH HOH C . 
O 4 HOH 198 598 815  HOH HOH C . 
O 4 HOH 199 599 513  HOH HOH C . 
O 4 HOH 200 600 219  HOH HOH C . 
O 4 HOH 201 601 1015 HOH HOH C . 
O 4 HOH 202 602 1104 HOH HOH C . 
O 4 HOH 203 603 1108 HOH HOH C . 
O 4 HOH 204 604 1100 HOH HOH C . 
O 4 HOH 205 605 682  HOH HOH C . 
O 4 HOH 206 606 326  HOH HOH C . 
O 4 HOH 207 607 454  HOH HOH C . 
O 4 HOH 208 608 950  HOH HOH C . 
O 4 HOH 209 609 439  HOH HOH C . 
O 4 HOH 210 610 1148 HOH HOH C . 
O 4 HOH 211 611 887  HOH HOH C . 
O 4 HOH 212 612 702  HOH HOH C . 
O 4 HOH 213 613 538  HOH HOH C . 
O 4 HOH 214 614 848  HOH HOH C . 
O 4 HOH 215 615 979  HOH HOH C . 
O 4 HOH 216 616 771  HOH HOH C . 
O 4 HOH 217 617 985  HOH HOH C . 
O 4 HOH 218 618 854  HOH HOH C . 
O 4 HOH 219 619 614  HOH HOH C . 
O 4 HOH 220 620 620  HOH HOH C . 
O 4 HOH 221 621 832  HOH HOH C . 
O 4 HOH 222 622 989  HOH HOH C . 
O 4 HOH 223 623 368  HOH HOH C . 
O 4 HOH 224 624 679  HOH HOH C . 
O 4 HOH 225 625 781  HOH HOH C . 
O 4 HOH 226 626 544  HOH HOH C . 
O 4 HOH 227 627 1067 HOH HOH C . 
O 4 HOH 228 628 944  HOH HOH C . 
O 4 HOH 229 629 1175 HOH HOH C . 
O 4 HOH 230 630 793  HOH HOH C . 
O 4 HOH 231 631 790  HOH HOH C . 
O 4 HOH 232 632 749  HOH HOH C . 
O 4 HOH 233 633 359  HOH HOH C . 
O 4 HOH 234 634 1091 HOH HOH C . 
O 4 HOH 235 635 547  HOH HOH C . 
O 4 HOH 236 636 431  HOH HOH C . 
O 4 HOH 237 637 635  HOH HOH C . 
O 4 HOH 238 638 821  HOH HOH C . 
O 4 HOH 239 639 1002 HOH HOH C . 
O 4 HOH 240 640 801  HOH HOH C . 
O 4 HOH 241 641 535  HOH HOH C . 
O 4 HOH 242 642 727  HOH HOH C . 
O 4 HOH 243 643 935  HOH HOH C . 
O 4 HOH 244 644 712  HOH HOH C . 
O 4 HOH 245 645 918  HOH HOH C . 
O 4 HOH 246 646 990  HOH HOH C . 
O 4 HOH 247 647 1106 HOH HOH C . 
O 4 HOH 248 648 804  HOH HOH C . 
O 4 HOH 249 649 270  HOH HOH C . 
O 4 HOH 250 650 681  HOH HOH C . 
O 4 HOH 251 651 1095 HOH HOH C . 
O 4 HOH 252 652 800  HOH HOH C . 
O 4 HOH 253 653 591  HOH HOH C . 
O 4 HOH 254 654 674  HOH HOH C . 
O 4 HOH 255 655 962  HOH HOH C . 
O 4 HOH 256 656 993  HOH HOH C . 
O 4 HOH 257 657 664  HOH HOH C . 
O 4 HOH 258 658 1107 HOH HOH C . 
O 4 HOH 259 659 523  HOH HOH C . 
O 4 HOH 260 660 649  HOH HOH C . 
O 4 HOH 261 661 545  HOH HOH C . 
O 4 HOH 262 662 1061 HOH HOH C . 
O 4 HOH 263 663 954  HOH HOH C . 
O 4 HOH 264 664 1176 HOH HOH C . 
O 4 HOH 265 665 996  HOH HOH C . 
O 4 HOH 266 666 1114 HOH HOH C . 
O 4 HOH 267 667 857  HOH HOH C . 
O 4 HOH 268 668 860  HOH HOH C . 
O 4 HOH 269 669 1153 HOH HOH C . 
P 4 HOH 1   401 115  HOH HOH D . 
P 4 HOH 2   402 1145 HOH HOH D . 
P 4 HOH 3   403 1120 HOH HOH D . 
P 4 HOH 4   404 599  HOH HOH D . 
P 4 HOH 5   405 500  HOH HOH D . 
P 4 HOH 6   406 551  HOH HOH D . 
P 4 HOH 7   407 383  HOH HOH D . 
P 4 HOH 8   408 374  HOH HOH D . 
P 4 HOH 9   409 1105 HOH HOH D . 
P 4 HOH 10  410 1135 HOH HOH D . 
P 4 HOH 11  411 1117 HOH HOH D . 
P 4 HOH 12  412 198  HOH HOH D . 
P 4 HOH 13  413 915  HOH HOH D . 
P 4 HOH 14  414 295  HOH HOH D . 
P 4 HOH 15  415 778  HOH HOH D . 
P 4 HOH 16  416 192  HOH HOH D . 
P 4 HOH 17  417 336  HOH HOH D . 
P 4 HOH 18  418 951  HOH HOH D . 
P 4 HOH 19  419 884  HOH HOH D . 
P 4 HOH 20  420 883  HOH HOH D . 
P 4 HOH 21  421 894  HOH HOH D . 
P 4 HOH 22  422 1151 HOH HOH D . 
P 4 HOH 23  423 314  HOH HOH D . 
P 4 HOH 24  424 850  HOH HOH D . 
P 4 HOH 25  425 589  HOH HOH D . 
P 4 HOH 26  426 33   HOH HOH D . 
P 4 HOH 27  427 339  HOH HOH D . 
P 4 HOH 28  428 1019 HOH HOH D . 
P 4 HOH 29  429 58   HOH HOH D . 
P 4 HOH 30  430 1134 HOH HOH D . 
P 4 HOH 31  431 1018 HOH HOH D . 
P 4 HOH 32  432 739  HOH HOH D . 
P 4 HOH 33  433 183  HOH HOH D . 
P 4 HOH 34  434 68   HOH HOH D . 
P 4 HOH 35  435 136  HOH HOH D . 
P 4 HOH 36  436 211  HOH HOH D . 
P 4 HOH 37  437 449  HOH HOH D . 
P 4 HOH 38  438 527  HOH HOH D . 
P 4 HOH 39  439 479  HOH HOH D . 
P 4 HOH 40  440 144  HOH HOH D . 
P 4 HOH 41  441 940  HOH HOH D . 
P 4 HOH 42  442 253  HOH HOH D . 
P 4 HOH 43  443 837  HOH HOH D . 
P 4 HOH 44  444 1141 HOH HOH D . 
P 4 HOH 45  445 536  HOH HOH D . 
P 4 HOH 46  446 1137 HOH HOH D . 
P 4 HOH 47  447 1023 HOH HOH D . 
P 4 HOH 48  448 369  HOH HOH D . 
P 4 HOH 49  449 642  HOH HOH D . 
P 4 HOH 50  450 310  HOH HOH D . 
P 4 HOH 51  451 65   HOH HOH D . 
P 4 HOH 52  452 1142 HOH HOH D . 
P 4 HOH 53  453 406  HOH HOH D . 
P 4 HOH 54  454 948  HOH HOH D . 
P 4 HOH 55  455 435  HOH HOH D . 
P 4 HOH 56  456 3    HOH HOH D . 
P 4 HOH 57  457 873  HOH HOH D . 
P 4 HOH 58  458 489  HOH HOH D . 
P 4 HOH 59  459 803  HOH HOH D . 
P 4 HOH 60  460 266  HOH HOH D . 
P 4 HOH 61  461 532  HOH HOH D . 
P 4 HOH 62  462 1173 HOH HOH D . 
P 4 HOH 63  463 1179 HOH HOH D . 
P 4 HOH 64  464 549  HOH HOH D . 
P 4 HOH 65  465 565  HOH HOH D . 
P 4 HOH 66  466 761  HOH HOH D . 
P 4 HOH 67  467 811  HOH HOH D . 
P 4 HOH 68  468 461  HOH HOH D . 
P 4 HOH 69  469 824  HOH HOH D . 
P 4 HOH 70  470 43   HOH HOH D . 
P 4 HOH 71  471 154  HOH HOH D . 
P 4 HOH 72  472 543  HOH HOH D . 
P 4 HOH 73  473 517  HOH HOH D . 
P 4 HOH 74  474 612  HOH HOH D . 
P 4 HOH 75  475 741  HOH HOH D . 
P 4 HOH 76  476 986  HOH HOH D . 
P 4 HOH 77  477 987  HOH HOH D . 
P 4 HOH 78  478 436  HOH HOH D . 
P 4 HOH 79  479 926  HOH HOH D . 
P 4 HOH 80  480 83   HOH HOH D . 
P 4 HOH 81  481 281  HOH HOH D . 
P 4 HOH 82  482 501  HOH HOH D . 
P 4 HOH 83  483 1128 HOH HOH D . 
P 4 HOH 84  484 395  HOH HOH D . 
P 4 HOH 85  485 62   HOH HOH D . 
P 4 HOH 86  486 93   HOH HOH D . 
P 4 HOH 87  487 907  HOH HOH D . 
P 4 HOH 88  488 81   HOH HOH D . 
P 4 HOH 89  489 514  HOH HOH D . 
P 4 HOH 90  490 392  HOH HOH D . 
P 4 HOH 91  491 2    HOH HOH D . 
P 4 HOH 92  492 372  HOH HOH D . 
P 4 HOH 93  493 15   HOH HOH D . 
P 4 HOH 94  494 694  HOH HOH D . 
P 4 HOH 95  495 613  HOH HOH D . 
P 4 HOH 96  496 659  HOH HOH D . 
P 4 HOH 97  497 262  HOH HOH D . 
P 4 HOH 98  498 456  HOH HOH D . 
P 4 HOH 99  499 57   HOH HOH D . 
P 4 HOH 100 500 799  HOH HOH D . 
P 4 HOH 101 501 588  HOH HOH D . 
P 4 HOH 102 502 152  HOH HOH D . 
P 4 HOH 103 503 149  HOH HOH D . 
P 4 HOH 104 504 866  HOH HOH D . 
P 4 HOH 105 505 494  HOH HOH D . 
P 4 HOH 106 506 40   HOH HOH D . 
P 4 HOH 107 507 21   HOH HOH D . 
P 4 HOH 108 508 946  HOH HOH D . 
P 4 HOH 109 509 54   HOH HOH D . 
P 4 HOH 110 510 23   HOH HOH D . 
P 4 HOH 111 511 46   HOH HOH D . 
P 4 HOH 112 512 726  HOH HOH D . 
P 4 HOH 113 513 895  HOH HOH D . 
P 4 HOH 114 514 1150 HOH HOH D . 
P 4 HOH 115 515 323  HOH HOH D . 
P 4 HOH 116 516 458  HOH HOH D . 
P 4 HOH 117 517 283  HOH HOH D . 
P 4 HOH 118 518 748  HOH HOH D . 
P 4 HOH 119 519 1020 HOH HOH D . 
P 4 HOH 120 520 131  HOH HOH D . 
P 4 HOH 121 521 6    HOH HOH D . 
P 4 HOH 122 522 609  HOH HOH D . 
P 4 HOH 123 523 453  HOH HOH D . 
P 4 HOH 124 524 191  HOH HOH D . 
P 4 HOH 125 525 101  HOH HOH D . 
P 4 HOH 126 526 142  HOH HOH D . 
P 4 HOH 127 527 102  HOH HOH D . 
P 4 HOH 128 528 699  HOH HOH D . 
P 4 HOH 129 529 508  HOH HOH D . 
P 4 HOH 130 530 200  HOH HOH D . 
P 4 HOH 131 531 330  HOH HOH D . 
P 4 HOH 132 532 104  HOH HOH D . 
P 4 HOH 133 533 17   HOH HOH D . 
P 4 HOH 134 534 1143 HOH HOH D . 
P 4 HOH 135 535 912  HOH HOH D . 
P 4 HOH 136 536 195  HOH HOH D . 
P 4 HOH 137 537 780  HOH HOH D . 
P 4 HOH 138 538 654  HOH HOH D . 
P 4 HOH 139 539 450  HOH HOH D . 
P 4 HOH 140 540 66   HOH HOH D . 
P 4 HOH 141 541 623  HOH HOH D . 
P 4 HOH 142 542 71   HOH HOH D . 
P 4 HOH 143 543 291  HOH HOH D . 
P 4 HOH 144 544 444  HOH HOH D . 
P 4 HOH 145 545 552  HOH HOH D . 
P 4 HOH 146 546 160  HOH HOH D . 
P 4 HOH 147 547 405  HOH HOH D . 
P 4 HOH 148 548 900  HOH HOH D . 
P 4 HOH 149 549 4    HOH HOH D . 
P 4 HOH 150 550 875  HOH HOH D . 
P 4 HOH 151 551 441  HOH HOH D . 
P 4 HOH 152 552 1139 HOH HOH D . 
P 4 HOH 153 553 1138 HOH HOH D . 
P 4 HOH 154 554 1131 HOH HOH D . 
P 4 HOH 155 555 645  HOH HOH D . 
P 4 HOH 156 556 35   HOH HOH D . 
P 4 HOH 157 557 465  HOH HOH D . 
P 4 HOH 158 558 353  HOH HOH D . 
P 4 HOH 159 559 282  HOH HOH D . 
P 4 HOH 160 560 143  HOH HOH D . 
P 4 HOH 161 561 462  HOH HOH D . 
P 4 HOH 162 562 165  HOH HOH D . 
P 4 HOH 163 563 342  HOH HOH D . 
P 4 HOH 164 564 644  HOH HOH D . 
P 4 HOH 165 565 418  HOH HOH D . 
P 4 HOH 166 566 56   HOH HOH D . 
P 4 HOH 167 567 277  HOH HOH D . 
P 4 HOH 168 568 652  HOH HOH D . 
P 4 HOH 169 569 221  HOH HOH D . 
P 4 HOH 170 570 126  HOH HOH D . 
P 4 HOH 171 571 107  HOH HOH D . 
P 4 HOH 172 572 346  HOH HOH D . 
P 4 HOH 173 573 280  HOH HOH D . 
P 4 HOH 174 574 631  HOH HOH D . 
P 4 HOH 175 575 515  HOH HOH D . 
P 4 HOH 176 576 585  HOH HOH D . 
P 4 HOH 177 577 120  HOH HOH D . 
P 4 HOH 178 578 911  HOH HOH D . 
P 4 HOH 179 579 347  HOH HOH D . 
P 4 HOH 180 580 168  HOH HOH D . 
P 4 HOH 181 581 80   HOH HOH D . 
P 4 HOH 182 582 91   HOH HOH D . 
P 4 HOH 183 583 255  HOH HOH D . 
P 4 HOH 184 584 680  HOH HOH D . 
P 4 HOH 185 585 276  HOH HOH D . 
P 4 HOH 186 586 390  HOH HOH D . 
P 4 HOH 187 587 744  HOH HOH D . 
P 4 HOH 188 588 885  HOH HOH D . 
P 4 HOH 189 589 331  HOH HOH D . 
P 4 HOH 190 590 251  HOH HOH D . 
P 4 HOH 191 591 994  HOH HOH D . 
P 4 HOH 192 592 934  HOH HOH D . 
P 4 HOH 193 593 806  HOH HOH D . 
P 4 HOH 194 594 1172 HOH HOH D . 
P 4 HOH 195 595 129  HOH HOH D . 
P 4 HOH 196 596 412  HOH HOH D . 
P 4 HOH 197 597 41   HOH HOH D . 
P 4 HOH 198 598 157  HOH HOH D . 
P 4 HOH 199 599 212  HOH HOH D . 
P 4 HOH 200 600 533  HOH HOH D . 
P 4 HOH 201 601 684  HOH HOH D . 
P 4 HOH 202 602 109  HOH HOH D . 
P 4 HOH 203 603 67   HOH HOH D . 
P 4 HOH 204 604 243  HOH HOH D . 
P 4 HOH 205 605 269  HOH HOH D . 
P 4 HOH 206 606 169  HOH HOH D . 
P 4 HOH 207 607 998  HOH HOH D . 
P 4 HOH 208 608 332  HOH HOH D . 
P 4 HOH 209 609 743  HOH HOH D . 
P 4 HOH 210 610 264  HOH HOH D . 
P 4 HOH 211 611 708  HOH HOH D . 
P 4 HOH 212 612 333  HOH HOH D . 
P 4 HOH 213 613 164  HOH HOH D . 
P 4 HOH 214 614 879  HOH HOH D . 
P 4 HOH 215 615 301  HOH HOH D . 
P 4 HOH 216 616 955  HOH HOH D . 
P 4 HOH 217 617 646  HOH HOH D . 
P 4 HOH 218 618 338  HOH HOH D . 
P 4 HOH 219 619 422  HOH HOH D . 
P 4 HOH 220 620 666  HOH HOH D . 
P 4 HOH 221 621 215  HOH HOH D . 
P 4 HOH 222 622 698  HOH HOH D . 
P 4 HOH 223 623 658  HOH HOH D . 
P 4 HOH 224 624 204  HOH HOH D . 
P 4 HOH 225 625 179  HOH HOH D . 
P 4 HOH 226 626 578  HOH HOH D . 
P 4 HOH 227 627 952  HOH HOH D . 
P 4 HOH 228 628 839  HOH HOH D . 
P 4 HOH 229 629 566  HOH HOH D . 
P 4 HOH 230 630 403  HOH HOH D . 
P 4 HOH 231 631 705  HOH HOH D . 
P 4 HOH 232 632 834  HOH HOH D . 
P 4 HOH 233 633 1021 HOH HOH D . 
P 4 HOH 234 634 437  HOH HOH D . 
P 4 HOH 235 635 421  HOH HOH D . 
P 4 HOH 236 636 648  HOH HOH D . 
P 4 HOH 237 637 1116 HOH HOH D . 
P 4 HOH 238 638 1149 HOH HOH D . 
P 4 HOH 239 639 933  HOH HOH D . 
P 4 HOH 240 640 516  HOH HOH D . 
P 4 HOH 241 641 19   HOH HOH D . 
P 4 HOH 242 642 812  HOH HOH D . 
P 4 HOH 243 643 410  HOH HOH D . 
P 4 HOH 244 644 904  HOH HOH D . 
P 4 HOH 245 645 742  HOH HOH D . 
P 4 HOH 246 646 797  HOH HOH D . 
P 4 HOH 247 647 969  HOH HOH D . 
P 4 HOH 248 648 1065 HOH HOH D . 
P 4 HOH 249 649 546  HOH HOH D . 
P 4 HOH 250 650 1125 HOH HOH D . 
P 4 HOH 251 651 949  HOH HOH D . 
P 4 HOH 252 652 561  HOH HOH D . 
P 4 HOH 253 653 1130 HOH HOH D . 
P 4 HOH 254 654 603  HOH HOH D . 
P 4 HOH 255 655 794  HOH HOH D . 
P 4 HOH 256 656 1136 HOH HOH D . 
P 4 HOH 257 657 1146 HOH HOH D . 
P 4 HOH 258 658 498  HOH HOH D . 
P 4 HOH 259 659 446  HOH HOH D . 
P 4 HOH 260 660 789  HOH HOH D . 
P 4 HOH 261 661 774  HOH HOH D . 
P 4 HOH 262 662 1124 HOH HOH D . 
P 4 HOH 263 663 602  HOH HOH D . 
P 4 HOH 264 664 704  HOH HOH D . 
P 4 HOH 265 665 242  HOH HOH D . 
P 4 HOH 266 666 713  HOH HOH D . 
P 4 HOH 267 667 670  HOH HOH D . 
P 4 HOH 268 668 718  HOH HOH D . 
P 4 HOH 269 669 730  HOH HOH D . 
P 4 HOH 270 670 931  HOH HOH D . 
P 4 HOH 271 671 759  HOH HOH D . 
P 4 HOH 272 672 316  HOH HOH D . 
P 4 HOH 273 673 820  HOH HOH D . 
P 4 HOH 274 674 358  HOH HOH D . 
P 4 HOH 275 675 298  HOH HOH D . 
P 4 HOH 276 676 180  HOH HOH D . 
P 4 HOH 277 677 829  HOH HOH D . 
P 4 HOH 278 678 728  HOH HOH D . 
P 4 HOH 279 679 1119 HOH HOH D . 
P 4 HOH 280 680 451  HOH HOH D . 
P 4 HOH 281 681 541  HOH HOH D . 
P 4 HOH 282 682 754  HOH HOH D . 
P 4 HOH 283 683 668  HOH HOH D . 
P 4 HOH 284 684 890  HOH HOH D . 
P 4 HOH 285 685 817  HOH HOH D . 
P 4 HOH 286 686 1126 HOH HOH D . 
P 4 HOH 287 687 1022 HOH HOH D . 
P 4 HOH 288 688 983  HOH HOH D . 
P 4 HOH 289 689 1132 HOH HOH D . 
P 4 HOH 290 690 947  HOH HOH D . 
P 4 HOH 291 691 511  HOH HOH D . 
P 4 HOH 292 692 570  HOH HOH D . 
P 4 HOH 293 693 957  HOH HOH D . 
P 4 HOH 294 694 964  HOH HOH D . 
P 4 HOH 295 695 798  HOH HOH D . 
P 4 HOH 296 696 1006 HOH HOH D . 
P 4 HOH 297 697 626  HOH HOH D . 
P 4 HOH 298 698 974  HOH HOH D . 
P 4 HOH 299 699 1122 HOH HOH D . 
P 4 HOH 300 700 278  HOH HOH D . 
P 4 HOH 301 701 470  HOH HOH D . 
P 4 HOH 302 702 729  HOH HOH D . 
P 4 HOH 303 703 736  HOH HOH D . 
P 4 HOH 304 704 230  HOH HOH D . 
P 4 HOH 305 705 818  HOH HOH D . 
P 4 HOH 306 706 567  HOH HOH D . 
P 4 HOH 307 707 1133 HOH HOH D . 
P 4 HOH 308 708 1144 HOH HOH D . 
P 4 HOH 309 709 313  HOH HOH D . 
P 4 HOH 310 710 734  HOH HOH D . 
P 4 HOH 311 711 583  HOH HOH D . 
P 4 HOH 312 712 965  HOH HOH D . 
P 4 HOH 313 713 1121 HOH HOH D . 
P 4 HOH 314 714 1118 HOH HOH D . 
P 4 HOH 315 715 720  HOH HOH D . 
P 4 HOH 316 716 673  HOH HOH D . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? REFMAC      ? ? ? 5.6.0117 1 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? SCALA       ? ? ? 3.3.20   2 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? 3.20     3 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? XDS         ? ? ? .        4 
? phasing           ? ? ? ? ? ? ? ? ? ? ? MOLREP      ? ? ? .        5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   108.970 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     5LLP 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     77.488 
_cell.length_a_esd                 ? 
_cell.length_b                     74.288 
_cell.length_b_esd                 ? 
_cell.length_c                     91.658 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
# 
_symmetry.entry_id                         5LLP 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   5LLP 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                      ? 
_exptl_crystal.density_diffrn              ? 
_exptl_crystal.density_Matthews            2.08 
_exptl_crystal.density_method              ? 
_exptl_crystal.density_percent_sol         40.4 
_exptl_crystal.description                 ? 
_exptl_crystal.F_000                       ? 
_exptl_crystal.id                          1 
_exptl_crystal.preparation                 ? 
_exptl_crystal.size_max                    ? 
_exptl_crystal.size_mid                    ? 
_exptl_crystal.size_min                    ? 
_exptl_crystal.size_rad                    ? 
_exptl_crystal.colour_lustre               ? 
_exptl_crystal.colour_modifier             ? 
_exptl_crystal.colour_primary              ? 
_exptl_crystal.density_meas                ? 
_exptl_crystal.density_meas_esd            ? 
_exptl_crystal.density_meas_gt             ? 
_exptl_crystal.density_meas_lt             ? 
_exptl_crystal.density_meas_temp           ? 
_exptl_crystal.density_meas_temp_esd       ? 
_exptl_crystal.density_meas_temp_gt        ? 
_exptl_crystal.density_meas_temp_lt        ? 
_exptl_crystal.pdbx_crystal_image_url      ? 
_exptl_crystal.pdbx_crystal_image_format   ? 
_exptl_crystal.pdbx_mosaicity              ? 
_exptl_crystal.pdbx_mosaicity_esd          ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp            291 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'Crystallization buffer: 0.1M ammonium citrate (pH 7), 0.2M ammonium sulfate and 26% PEG4000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.ambient_environment    ? 
_diffrn.ambient_temp           100 
_diffrn.ambient_temp_details   ? 
_diffrn.ambient_temp_esd       ? 
_diffrn.crystal_id             1 
_diffrn.crystal_support        ? 
_diffrn.crystal_treatment      ? 
_diffrn.details                ? 
_diffrn.id                     1 
_diffrn.ambient_pressure       ? 
_diffrn.ambient_pressure_esd   ? 
_diffrn.ambient_pressure_gt    ? 
_diffrn.ambient_pressure_lt    ? 
_diffrn.ambient_temp_gt        ? 
_diffrn.ambient_temp_lt        ? 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M-F' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2013-05-23 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.826606 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.826606 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'P14 (MX2)' 
_diffrn_source.pdbx_synchrotron_site       'PETRA III, EMBL c/o DESY' 
# 
_reflns.B_iso_Wilson_estimate            12.282 
_reflns.entry_id                         5LLP 
_reflns.data_reduction_details           ? 
_reflns.data_reduction_method            ? 
_reflns.d_resolution_high                1.480 
_reflns.d_resolution_low                 73.280 
_reflns.details                          ? 
_reflns.limit_h_max                      ? 
_reflns.limit_h_min                      ? 
_reflns.limit_k_max                      ? 
_reflns.limit_k_min                      ? 
_reflns.limit_l_max                      ? 
_reflns.limit_l_min                      ? 
_reflns.number_all                       ? 
_reflns.number_obs                       160218 
_reflns.observed_criterion               ? 
_reflns.observed_criterion_F_max         ? 
_reflns.observed_criterion_F_min         ? 
_reflns.observed_criterion_I_max         ? 
_reflns.observed_criterion_I_min         ? 
_reflns.observed_criterion_sigma_F       ? 
_reflns.observed_criterion_sigma_I       ? 
_reflns.percent_possible_obs             98.100 
_reflns.R_free_details                   ? 
_reflns.Rmerge_F_all                     ? 
_reflns.Rmerge_F_obs                     ? 
_reflns.Friedel_coverage                 ? 
_reflns.number_gt                        ? 
_reflns.threshold_expression             ? 
_reflns.pdbx_redundancy                  6.900 
_reflns.pdbx_Rmerge_I_obs                ? 
_reflns.pdbx_Rmerge_I_all                ? 
_reflns.pdbx_Rsym_value                  0.062 
_reflns.pdbx_netI_over_av_sigmaI         5.961 
_reflns.pdbx_netI_over_sigmaI            15.700 
_reflns.pdbx_res_netI_over_av_sigmaI_2   ? 
_reflns.pdbx_res_netI_over_sigmaI_2      ? 
_reflns.pdbx_chi_squared                 ? 
_reflns.pdbx_scaling_rejects             ? 
_reflns.pdbx_d_res_high_opt              ? 
_reflns.pdbx_d_res_low_opt               ? 
_reflns.pdbx_d_res_opt_method            ? 
_reflns.phase_calculation_details        ? 
_reflns.pdbx_Rrim_I_all                  ? 
_reflns.pdbx_Rpim_I_all                  ? 
_reflns.pdbx_d_opt                       ? 
_reflns.pdbx_number_measured_all         ? 
_reflns.pdbx_diffrn_id                   1 
_reflns.pdbx_ordinal                     1 
_reflns.pdbx_CC_half                     ? 
_reflns.pdbx_R_split                     ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_all 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_R_split 
1.480 1.560  ? 2.400  ? ? ? ? ? 96.600 ? ? ? ? 0.256 ? ? ? ? ? ? ? ? 6.900 ? ? ? ? ? ? ? 1  1 ? ? 
1.560 1.650  ? 3.600  ? ? ? ? ? 97.400 ? ? ? ? 0.177 ? ? ? ? ? ? ? ? 6.700 ? ? ? ? ? ? ? 2  1 ? ? 
1.650 1.770  ? 5.200  ? ? ? ? ? 97.700 ? ? ? ? 0.125 ? ? ? ? ? ? ? ? 6.900 ? ? ? ? ? ? ? 3  1 ? ? 
1.770 1.910  ? 7.000  ? ? ? ? ? 97.600 ? ? ? ? 0.091 ? ? ? ? ? ? ? ? 7.100 ? ? ? ? ? ? ? 4  1 ? ? 
1.910 2.090  ? 8.500  ? ? ? ? ? 98.600 ? ? ? ? 0.071 ? ? ? ? ? ? ? ? 7.100 ? ? ? ? ? ? ? 5  1 ? ? 
2.090 2.340  ? 9.500  ? ? ? ? ? 99.000 ? ? ? ? 0.062 ? ? ? ? ? ? ? ? 7.000 ? ? ? ? ? ? ? 6  1 ? ? 
2.340 2.700  ? 10.500 ? ? ? ? ? 98.800 ? ? ? ? 0.055 ? ? ? ? ? ? ? ? 7.000 ? ? ? ? ? ? ? 7  1 ? ? 
2.700 3.310  ? 10.300 ? ? ? ? ? 99.600 ? ? ? ? 0.052 ? ? ? ? ? ? ? ? 7.000 ? ? ? ? ? ? ? 8  1 ? ? 
3.310 4.680  ? 11.500 ? ? ? ? ? 99.600 ? ? ? ? 0.045 ? ? ? ? ? ? ? ? 6.600 ? ? ? ? ? ? ? 9  1 ? ? 
4.680 73.280 ? 7.900  ? ? ? ? ? 99.400 ? ? ? ? 0.045 ? ? ? ? ? ? ? ? 7.000 ? ? ? ? ? ? ? 10 1 ? ? 
# 
_refine.aniso_B[1][1]                            -0.0600 
_refine.aniso_B[1][2]                            0.0000 
_refine.aniso_B[1][3]                            0.1100 
_refine.aniso_B[2][2]                            0.2200 
_refine.aniso_B[2][3]                            0.0000 
_refine.aniso_B[3][3]                            -0.0900 
_refine.B_iso_max                                79.770 
_refine.B_iso_mean                               15.6190 
_refine.B_iso_min                                3.160 
_refine.correlation_coeff_Fo_to_Fc               0.9690 
_refine.correlation_coeff_Fo_to_Fc_free          0.9550 
_refine.details                                  
'HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT U VALUES      : REFINED INDIVIDUALLY' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 5LLP 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.4800 
_refine.ls_d_res_low                             73.2800 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     144263 
_refine.ls_number_reflns_R_free                  15901 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    97.9100 
_refine.ls_percent_reflns_R_free                 9.9000 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1670 
_refine.ls_R_factor_R_free                       0.1987 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1635 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          0.000 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      1JD0 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.0780 
_refine.pdbx_overall_ESU_R_Free                  0.0810 
_refine.pdbx_solvent_vdw_probe_radii             1.4000 
_refine.pdbx_solvent_ion_probe_radii             0.8000 
_refine.pdbx_solvent_shrinkage_radii             0.8000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             0.0779 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.cycle_id                         final 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.d_res_high                       1.4800 
_refine_hist.d_res_low                        73.2800 
_refine_hist.pdbx_number_atoms_ligand         154 
_refine_hist.number_atoms_solvent             1184 
_refine_hist.number_atoms_total               9703 
_refine_hist.pdbx_number_residues_total       1041 
_refine_hist.pdbx_B_iso_mean_ligand           22.39 
_refine_hist.pdbx_B_iso_mean_solvent          25.57 
_refine_hist.pdbx_number_atoms_protein        8365 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.024  0.020  9062  ? r_bond_refined_d       ? ? 
'X-RAY DIFFRACTION' ? 2.339  1.962  12409 ? r_angle_refined_deg    ? ? 
'X-RAY DIFFRACTION' ? 7.487  5.000  1098  ? r_dihedral_angle_1_deg ? ? 
'X-RAY DIFFRACTION' ? 37.214 24.578 450   ? r_dihedral_angle_2_deg ? ? 
'X-RAY DIFFRACTION' ? 13.348 15.000 1409  ? r_dihedral_angle_3_deg ? ? 
'X-RAY DIFFRACTION' ? 15.036 15.000 35    ? r_dihedral_angle_4_deg ? ? 
'X-RAY DIFFRACTION' ? 0.160  0.200  1285  ? r_chiral_restr         ? ? 
'X-RAY DIFFRACTION' ? 0.014  0.021  7192  ? r_gen_planes_refined   ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       1.4800 
_refine_ls_shell.d_res_low                        1.5180 
_refine_ls_shell.number_reflns_all                11544 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             1171 
_refine_ls_shell.number_reflns_R_work             10373 
_refine_ls_shell.percent_reflns_obs               95.9300 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free                  0.2330 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.1800 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
# 
_struct.entry_id                     5LLP 
_struct.title                        
;Crystal structure of human carbonic anhydrase isozyme XII with 3-[(1S)-1,2,3,4-Tetrahydronapthalen-1-ylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        5LLP 
_struct_keywords.text            
'drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor comple, lyase' 
_struct_keywords.pdbx_keywords   LYASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
D N N 1 ? 
E N N 2 ? 
F N N 3 ? 
G N N 2 ? 
H N N 3 ? 
I N N 2 ? 
J N N 3 ? 
K N N 2 ? 
L N N 3 ? 
M N N 4 ? 
N N N 4 ? 
O N N 4 ? 
P N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    CAH12_HUMAN 
_struct_ref.pdbx_db_accession          O43570 
_struct_ref.pdbx_db_isoform            O43570-2 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGL
QSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSH
LQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPRE
MINNFRQVQKFDERLVYTSFSQ
;
_struct_ref.pdbx_align_begin           30 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 5LLP A 2 ? 263 ? O43570 30 ? 291 ? 2 263 
2 1 5LLP B 2 ? 263 ? O43570 30 ? 291 ? 2 263 
3 1 5LLP C 2 ? 263 ? O43570 30 ? 291 ? 2 263 
4 1 5LLP D 2 ? 263 ? O43570 30 ? 291 ? 2 263 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 5LLP MET A 1 ? UNP O43570 ? ? 'initiating methionine' 1 1 
2 5LLP MET B 1 ? UNP O43570 ? ? 'initiating methionine' 1 2 
3 5LLP MET C 1 ? UNP O43570 ? ? 'initiating methionine' 1 3 
4 5LLP MET D 1 ? UNP O43570 ? ? 'initiating methionine' 1 4 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? dimeric 2 
2 author_defined_assembly ? dimeric 2 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,E,F,G,H,M,N 
2 1 C,D,I,J,K,L,O,P 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PHE A 7   ? TRP A 15  ? PHE A 7   TRP A 15  5 ? 9  
HELX_P HELX_P2  AA2 TYR A 19  ? GLY A 24  ? TYR A 19  GLY A 24  5 ? 6  
HELX_P HELX_P3  AA3 HIS A 33  ? ASP A 35  ? HIS A 33  ASP A 35  5 ? 3  
HELX_P HELX_P4  AA4 ASP A 128 ? ASN A 134 ? ASP A 128 ASN A 134 1 ? 7  
HELX_P HELX_P5  AA5 ASN A 152 ? SER A 160 ? ASN A 152 SER A 160 1 ? 9  
HELX_P HELX_P6  AA6 HIS A 161 ? LYS A 166 ? HIS A 161 LYS A 166 5 ? 6  
HELX_P HELX_P7  AA7 ASN A 178 ? LEU A 183 ? ASN A 178 LEU A 183 5 ? 6  
HELX_P HELX_P8  AA8 SER A 218 ? ALA A 228 ? SER A 218 ALA A 228 1 ? 11 
HELX_P HELX_P9  AA9 GLY B 11  ? LYS B 18  ? GLY B 11  LYS B 18  5 ? 8  
HELX_P HELX_P10 AB1 TYR B 19  ? GLY B 24  ? TYR B 19  GLY B 24  5 ? 6  
HELX_P HELX_P11 AB2 HIS B 33  ? ASP B 35  ? HIS B 33  ASP B 35  5 ? 3  
HELX_P HELX_P12 AB3 ASP B 128 ? SER B 133 ? ASP B 128 SER B 133 1 ? 6  
HELX_P HELX_P13 AB4 ASN B 152 ? SER B 160 ? ASN B 152 SER B 160 1 ? 9  
HELX_P HELX_P14 AB5 HIS B 161 ? VAL B 165 ? HIS B 161 VAL B 165 5 ? 5  
HELX_P HELX_P15 AB6 ASN B 178 ? LEU B 183 ? ASN B 178 LEU B 183 5 ? 6  
HELX_P HELX_P16 AB7 SER B 218 ? ALA B 228 ? SER B 218 ALA B 228 1 ? 11 
HELX_P HELX_P17 AB8 PHE C 7   ? GLY C 11  ? PHE C 7   GLY C 11  5 ? 5  
HELX_P HELX_P18 AB9 SER C 14  ? LYS C 18  ? SER C 14  LYS C 18  5 ? 5  
HELX_P HELX_P19 AC1 TYR C 19  ? GLY C 24  ? TYR C 19  GLY C 24  5 ? 6  
HELX_P HELX_P20 AC2 HIS C 33  ? ASP C 35  ? HIS C 33  ASP C 35  5 ? 3  
HELX_P HELX_P21 AC3 ASP C 128 ? SER C 133 ? ASP C 128 SER C 133 1 ? 6  
HELX_P HELX_P22 AC4 ASN C 152 ? SER C 160 ? ASN C 152 SER C 160 1 ? 9  
HELX_P HELX_P23 AC5 HIS C 161 ? VAL C 165 ? HIS C 161 VAL C 165 5 ? 5  
HELX_P HELX_P24 AC6 ASN C 178 ? LEU C 183 ? ASN C 178 LEU C 183 5 ? 6  
HELX_P HELX_P25 AC7 SER C 218 ? LEU C 229 ? SER C 218 LEU C 229 1 ? 12 
HELX_P HELX_P26 AC8 GLY D 11  ? LYS D 18  ? GLY D 11  LYS D 18  5 ? 8  
HELX_P HELX_P27 AC9 TYR D 19  ? GLY D 24  ? TYR D 19  GLY D 24  5 ? 6  
HELX_P HELX_P28 AD1 HIS D 33  ? ASP D 35  ? HIS D 33  ASP D 35  5 ? 3  
HELX_P HELX_P29 AD2 ASP D 128 ? SER D 133 ? ASP D 128 SER D 133 1 ? 6  
HELX_P HELX_P30 AD3 ASN D 152 ? SER D 160 ? ASN D 152 SER D 160 1 ? 9  
HELX_P HELX_P31 AD4 HIS D 161 ? LYS D 166 ? HIS D 161 LYS D 166 5 ? 6  
HELX_P HELX_P32 AD5 ASN D 178 ? LEU D 183 ? ASN D 178 LEU D 183 5 ? 6  
HELX_P HELX_P33 AD6 SER D 218 ? ALA D 228 ? SER D 218 ALA D 228 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ? ? A CYS 22  SG  ? ? ? 1_555 A CYS 202 SG  ? ? A CYS 22  A CYS 202 1_555 ? ? ? ? ? ? ? 2.087 ? ? 
disulf2  disulf ? ? B CYS 22  SG  ? ? ? 1_555 B CYS 202 SG  ? ? B CYS 22  B CYS 202 1_555 ? ? ? ? ? ? ? 2.056 ? ? 
disulf3  disulf ? ? C CYS 22  SG  ? ? ? 1_555 C CYS 202 SG  ? ? C CYS 22  C CYS 202 1_555 ? ? ? ? ? ? ? 2.050 ? ? 
disulf4  disulf ? ? D CYS 22  SG  ? ? ? 1_555 D CYS 202 SG  ? ? D CYS 22  D CYS 202 1_555 ? ? ? ? ? ? ? 2.040 ? ? 
metalc1  metalc ? ? A HIS 91  NE2 ? ? ? 1_555 E ZN  .   ZN  ? ? A HIS 91  A ZN  301 1_555 ? ? ? ? ? ? ? 2.013 ? ? 
metalc2  metalc ? ? A HIS 93  NE2 ? ? ? 1_555 E ZN  .   ZN  ? ? A HIS 93  A ZN  301 1_555 ? ? ? ? ? ? ? 2.001 ? ? 
metalc3  metalc ? ? A HIS 117 ND1 ? ? ? 1_555 E ZN  .   ZN  ? ? A HIS 117 A ZN  301 1_555 ? ? ? ? ? ? ? 1.981 ? ? 
metalc4  metalc ? ? E ZN  .   ZN  ? ? ? 1_555 F 6Z9 .   S2  A ? A ZN  301 A 6Z9 302 1_555 ? ? ? ? ? ? ? 2.994 ? ? 
metalc5  metalc ? ? E ZN  .   ZN  ? ? ? 1_555 F 6Z9 .   N29 A ? A ZN  301 A 6Z9 302 1_555 ? ? ? ? ? ? ? 1.915 ? ? 
metalc6  metalc ? ? E ZN  .   ZN  ? ? ? 1_555 F 6Z9 .   N29 B ? A ZN  301 A 6Z9 302 1_555 ? ? ? ? ? ? ? 1.912 ? ? 
metalc7  metalc ? ? B HIS 91  NE2 ? ? ? 1_555 G ZN  .   ZN  ? ? B HIS 91  B ZN  301 1_555 ? ? ? ? ? ? ? 2.019 ? ? 
metalc8  metalc ? ? B HIS 93  NE2 ? ? ? 1_555 G ZN  .   ZN  ? ? B HIS 93  B ZN  301 1_555 ? ? ? ? ? ? ? 2.046 ? ? 
metalc9  metalc ? ? B HIS 117 ND1 ? ? ? 1_555 G ZN  .   ZN  ? ? B HIS 117 B ZN  301 1_555 ? ? ? ? ? ? ? 2.011 ? ? 
metalc10 metalc ? ? G ZN  .   ZN  ? ? ? 1_555 H 6Z9 .   N29 ? ? B ZN  301 B 6Z9 302 1_555 ? ? ? ? ? ? ? 1.859 ? ? 
metalc11 metalc ? ? C HIS 91  NE2 ? ? ? 1_555 I ZN  .   ZN  ? ? C HIS 91  C ZN  301 1_555 ? ? ? ? ? ? ? 2.005 ? ? 
metalc12 metalc ? ? C HIS 93  NE2 ? ? ? 1_555 I ZN  .   ZN  ? ? C HIS 93  C ZN  301 1_555 ? ? ? ? ? ? ? 2.037 ? ? 
metalc13 metalc ? ? C HIS 117 ND1 ? ? ? 1_555 I ZN  .   ZN  ? ? C HIS 117 C ZN  301 1_555 ? ? ? ? ? ? ? 1.983 ? ? 
metalc14 metalc ? ? I ZN  .   ZN  ? ? ? 1_555 J 6Z9 .   N29 ? ? C ZN  301 C 6Z9 302 1_555 ? ? ? ? ? ? ? 1.903 ? ? 
metalc15 metalc ? ? D HIS 91  NE2 ? ? ? 1_555 K ZN  .   ZN  ? ? D HIS 91  D ZN  301 1_555 ? ? ? ? ? ? ? 1.991 ? ? 
metalc16 metalc ? ? D HIS 93  NE2 ? ? ? 1_555 K ZN  .   ZN  ? ? D HIS 93  D ZN  301 1_555 ? ? ? ? ? ? ? 2.008 ? ? 
metalc17 metalc ? ? D HIS 117 ND1 ? ? ? 1_555 K ZN  .   ZN  ? ? D HIS 117 D ZN  301 1_555 ? ? ? ? ? ? ? 2.011 ? ? 
metalc18 metalc ? ? K ZN  .   ZN  ? ? ? 1_555 L 6Z9 .   N29 ? ? D ZN  301 D 6Z9 302 1_555 ? ? ? ? ? ? ? 1.949 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS 91  ? A HIS 91  ? 1_555 ZN ? E ZN . ? A ZN 301 ? 1_555 NE2 ? A HIS 93  ? A HIS 93  ? 1_555 103.2 ? 
2  NE2 ? A HIS 91  ? A HIS 91  ? 1_555 ZN ? E ZN . ? A ZN 301 ? 1_555 ND1 ? A HIS 117 ? A HIS 117 ? 1_555 108.7 ? 
3  NE2 ? A HIS 93  ? A HIS 93  ? 1_555 ZN ? E ZN . ? A ZN 301 ? 1_555 ND1 ? A HIS 117 ? A HIS 117 ? 1_555 99.5  ? 
4  NE2 ? A HIS 91  ? A HIS 91  ? 1_555 ZN ? E ZN . ? A ZN 301 ? 1_555 S2  A F 6Z9 .   ? A 6Z9 302 ? 1_555 94.1  ? 
5  NE2 ? A HIS 93  ? A HIS 93  ? 1_555 ZN ? E ZN . ? A ZN 301 ? 1_555 S2  A F 6Z9 .   ? A 6Z9 302 ? 1_555 139.3 ? 
6  ND1 ? A HIS 117 ? A HIS 117 ? 1_555 ZN ? E ZN . ? A ZN 301 ? 1_555 S2  A F 6Z9 .   ? A 6Z9 302 ? 1_555 109.5 ? 
7  NE2 ? A HIS 91  ? A HIS 91  ? 1_555 ZN ? E ZN . ? A ZN 301 ? 1_555 N29 A F 6Z9 .   ? A 6Z9 302 ? 1_555 121.3 ? 
8  NE2 ? A HIS 93  ? A HIS 93  ? 1_555 ZN ? E ZN . ? A ZN 301 ? 1_555 N29 A F 6Z9 .   ? A 6Z9 302 ? 1_555 114.5 ? 
9  ND1 ? A HIS 117 ? A HIS 117 ? 1_555 ZN ? E ZN . ? A ZN 301 ? 1_555 N29 A F 6Z9 .   ? A 6Z9 302 ? 1_555 107.4 ? 
10 S2  A F 6Z9 .   ? A 6Z9 302 ? 1_555 ZN ? E ZN . ? A ZN 301 ? 1_555 N29 A F 6Z9 .   ? A 6Z9 302 ? 1_555 29.9  ? 
11 NE2 ? A HIS 91  ? A HIS 91  ? 1_555 ZN ? E ZN . ? A ZN 301 ? 1_555 N29 B F 6Z9 .   ? A 6Z9 302 ? 1_555 121.8 ? 
12 NE2 ? A HIS 93  ? A HIS 93  ? 1_555 ZN ? E ZN . ? A ZN 301 ? 1_555 N29 B F 6Z9 .   ? A 6Z9 302 ? 1_555 114.4 ? 
13 ND1 ? A HIS 117 ? A HIS 117 ? 1_555 ZN ? E ZN . ? A ZN 301 ? 1_555 N29 B F 6Z9 .   ? A 6Z9 302 ? 1_555 107.0 ? 
14 S2  A F 6Z9 .   ? A 6Z9 302 ? 1_555 ZN ? E ZN . ? A ZN 301 ? 1_555 N29 B F 6Z9 .   ? A 6Z9 302 ? 1_555 30.2  ? 
15 N29 A F 6Z9 .   ? A 6Z9 302 ? 1_555 ZN ? E ZN . ? A ZN 301 ? 1_555 N29 B F 6Z9 .   ? A 6Z9 302 ? 1_555 0.5   ? 
16 NE2 ? B HIS 91  ? B HIS 91  ? 1_555 ZN ? G ZN . ? B ZN 301 ? 1_555 NE2 ? B HIS 93  ? B HIS 93  ? 1_555 104.3 ? 
17 NE2 ? B HIS 91  ? B HIS 91  ? 1_555 ZN ? G ZN . ? B ZN 301 ? 1_555 ND1 ? B HIS 117 ? B HIS 117 ? 1_555 110.9 ? 
18 NE2 ? B HIS 93  ? B HIS 93  ? 1_555 ZN ? G ZN . ? B ZN 301 ? 1_555 ND1 ? B HIS 117 ? B HIS 117 ? 1_555 99.8  ? 
19 NE2 ? B HIS 91  ? B HIS 91  ? 1_555 ZN ? G ZN . ? B ZN 301 ? 1_555 N29 ? H 6Z9 .   ? B 6Z9 302 ? 1_555 118.8 ? 
20 NE2 ? B HIS 93  ? B HIS 93  ? 1_555 ZN ? G ZN . ? B ZN 301 ? 1_555 N29 ? H 6Z9 .   ? B 6Z9 302 ? 1_555 113.4 ? 
21 ND1 ? B HIS 117 ? B HIS 117 ? 1_555 ZN ? G ZN . ? B ZN 301 ? 1_555 N29 ? H 6Z9 .   ? B 6Z9 302 ? 1_555 108.0 ? 
22 NE2 ? C HIS 91  ? C HIS 91  ? 1_555 ZN ? I ZN . ? C ZN 301 ? 1_555 NE2 ? C HIS 93  ? C HIS 93  ? 1_555 101.3 ? 
23 NE2 ? C HIS 91  ? C HIS 91  ? 1_555 ZN ? I ZN . ? C ZN 301 ? 1_555 ND1 ? C HIS 117 ? C HIS 117 ? 1_555 113.5 ? 
24 NE2 ? C HIS 93  ? C HIS 93  ? 1_555 ZN ? I ZN . ? C ZN 301 ? 1_555 ND1 ? C HIS 117 ? C HIS 117 ? 1_555 98.9  ? 
25 NE2 ? C HIS 91  ? C HIS 91  ? 1_555 ZN ? I ZN . ? C ZN 301 ? 1_555 N29 ? J 6Z9 .   ? C 6Z9 302 ? 1_555 117.6 ? 
26 NE2 ? C HIS 93  ? C HIS 93  ? 1_555 ZN ? I ZN . ? C ZN 301 ? 1_555 N29 ? J 6Z9 .   ? C 6Z9 302 ? 1_555 115.3 ? 
27 ND1 ? C HIS 117 ? C HIS 117 ? 1_555 ZN ? I ZN . ? C ZN 301 ? 1_555 N29 ? J 6Z9 .   ? C 6Z9 302 ? 1_555 108.6 ? 
28 NE2 ? D HIS 91  ? D HIS 91  ? 1_555 ZN ? K ZN . ? D ZN 301 ? 1_555 NE2 ? D HIS 93  ? D HIS 93  ? 1_555 104.0 ? 
29 NE2 ? D HIS 91  ? D HIS 91  ? 1_555 ZN ? K ZN . ? D ZN 301 ? 1_555 ND1 ? D HIS 117 ? D HIS 117 ? 1_555 110.9 ? 
30 NE2 ? D HIS 93  ? D HIS 93  ? 1_555 ZN ? K ZN . ? D ZN 301 ? 1_555 ND1 ? D HIS 117 ? D HIS 117 ? 1_555 99.5  ? 
31 NE2 ? D HIS 91  ? D HIS 91  ? 1_555 ZN ? K ZN . ? D ZN 301 ? 1_555 N29 ? L 6Z9 .   ? D 6Z9 302 ? 1_555 118.5 ? 
32 NE2 ? D HIS 93  ? D HIS 93  ? 1_555 ZN ? K ZN . ? D ZN 301 ? 1_555 N29 ? L 6Z9 .   ? D 6Z9 302 ? 1_555 114.3 ? 
33 ND1 ? D HIS 117 ? D HIS 117 ? 1_555 ZN ? K ZN . ? D ZN 301 ? 1_555 N29 ? L 6Z9 .   ? D 6Z9 302 ? 1_555 108.1 ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 22 ? CYS A 202 ? CYS A 22 ? 1_555 CYS A 202 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS B 22 ? CYS B 202 ? CYS B 22 ? 1_555 CYS B 202 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS C 22 ? CYS C 202 ? CYS C 22 ? 1_555 CYS C 202 ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS D 22 ? CYS D 202 ? CYS D 22 ? 1_555 CYS D 202 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 SER 28  A . ? SER 28  A PRO 29  A ? PRO 29  A 1 -0.35 
2 PRO 200 A . ? PRO 200 A PRO 201 A ? PRO 201 A 1 6.72  
3 SER 28  B . ? SER 28  B PRO 29  B ? PRO 29  B 1 -2.03 
4 PRO 200 B . ? PRO 200 B PRO 201 B ? PRO 201 B 1 10.52 
5 SER 28  C . ? SER 28  C PRO 29  C ? PRO 29  C 1 3.56  
6 PRO 200 C . ? PRO 200 C PRO 201 C ? PRO 201 C 1 9.35  
7 SER 28  D . ? SER 28  D PRO 29  D ? PRO 29  D 1 1.39  
8 PRO 200 D . ? PRO 200 D PRO 201 D ? PRO 201 D 1 2.45  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2  ? 
AA2 ? 10 ? 
AA3 ? 6  ? 
AA4 ? 2  ? 
AA5 ? 10 ? 
AA6 ? 6  ? 
AA7 ? 2  ? 
AA8 ? 10 ? 
AA9 ? 6  ? 
AB1 ? 2  ? 
AB2 ? 10 ? 
AB3 ? 6  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2  ? parallel      
AA2 1 2  ? parallel      
AA2 2 3  ? anti-parallel 
AA2 3 4  ? anti-parallel 
AA2 4 5  ? parallel      
AA2 5 6  ? anti-parallel 
AA2 6 7  ? anti-parallel 
AA2 7 8  ? anti-parallel 
AA2 8 9  ? anti-parallel 
AA2 9 10 ? anti-parallel 
AA3 1 2  ? anti-parallel 
AA3 2 3  ? anti-parallel 
AA3 3 4  ? anti-parallel 
AA3 4 5  ? anti-parallel 
AA3 5 6  ? parallel      
AA4 1 2  ? parallel      
AA5 1 2  ? parallel      
AA5 2 3  ? anti-parallel 
AA5 3 4  ? anti-parallel 
AA5 4 5  ? parallel      
AA5 5 6  ? anti-parallel 
AA5 6 7  ? anti-parallel 
AA5 7 8  ? anti-parallel 
AA5 8 9  ? anti-parallel 
AA5 9 10 ? anti-parallel 
AA6 1 2  ? anti-parallel 
AA6 2 3  ? anti-parallel 
AA6 3 4  ? anti-parallel 
AA6 4 5  ? anti-parallel 
AA6 5 6  ? parallel      
AA7 1 2  ? parallel      
AA8 1 2  ? parallel      
AA8 2 3  ? anti-parallel 
AA8 3 4  ? anti-parallel 
AA8 4 5  ? parallel      
AA8 5 6  ? anti-parallel 
AA8 6 7  ? anti-parallel 
AA8 7 8  ? anti-parallel 
AA8 8 9  ? anti-parallel 
AA8 9 10 ? anti-parallel 
AA9 1 2  ? anti-parallel 
AA9 2 3  ? anti-parallel 
AA9 3 4  ? anti-parallel 
AA9 4 5  ? anti-parallel 
AA9 5 6  ? parallel      
AB1 1 2  ? parallel      
AB2 1 2  ? parallel      
AB2 2 3  ? anti-parallel 
AB2 3 4  ? anti-parallel 
AB2 4 5  ? parallel      
AB2 5 6  ? anti-parallel 
AB2 6 7  ? anti-parallel 
AB2 7 8  ? anti-parallel 
AB2 8 9  ? anti-parallel 
AB2 9 10 ? anti-parallel 
AB3 1 2  ? anti-parallel 
AB3 2 3  ? anti-parallel 
AB3 3 4  ? anti-parallel 
AB3 4 5  ? anti-parallel 
AB3 5 6  ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  ASP A 31  ? LEU A 32  ? ASP A 31  LEU A 32  
AA1 2  THR A 106 ? VAL A 107 ? THR A 106 VAL A 107 
AA2 1  LEU A 37  ? TYR A 39  ? LEU A 37  TYR A 39  
AA2 2  VAL A 257 ? THR A 259 ? VAL A 257 THR A 259 
AA2 3  TYR A 190 ? GLY A 195 ? TYR A 190 GLY A 195 
AA2 4  VAL A 206 ? PHE A 211 ? VAL A 206 PHE A 211 
AA2 5  LEU A 139 ? MET A 148 ? LEU A 139 MET A 148 
AA2 6  ALA A 114 ? ASN A 122 ? ALA A 114 ASN A 122 
AA2 7  TYR A 85  ? TRP A 94  ? TYR A 85  TRP A 94  
AA2 8  VAL A 68  ? ASN A 71  ? VAL A 68  ASN A 71  
AA2 9  GLN A 58  ? ASN A 63  ? GLN A 58  ASN A 63  
AA2 10 GLU A 171 ? PRO A 175 ? GLU A 171 PRO A 175 
AA3 1  GLU A 47  ? GLN A 49  ? GLU A 47  GLN A 49  
AA3 2  HIS A 77  ? GLN A 79  ? HIS A 77  GLN A 79  
AA3 3  TYR A 85  ? TRP A 94  ? TYR A 85  TRP A 94  
AA3 4  ALA A 114 ? ASN A 122 ? ALA A 114 ASN A 122 
AA3 5  LEU A 139 ? MET A 148 ? LEU A 139 MET A 148 
AA3 6  VAL A 215 ? ILE A 217 ? VAL A 215 ILE A 217 
AA4 1  ASP B 31  ? LEU B 32  ? ASP B 31  LEU B 32  
AA4 2  THR B 106 ? VAL B 107 ? THR B 106 VAL B 107 
AA5 1  LEU B 37  ? TYR B 39  ? LEU B 37  TYR B 39  
AA5 2  VAL B 257 ? THR B 259 ? VAL B 257 THR B 259 
AA5 3  TYR B 190 ? GLY B 195 ? TYR B 190 GLY B 195 
AA5 4  VAL B 206 ? PHE B 211 ? VAL B 206 PHE B 211 
AA5 5  LEU B 139 ? MET B 148 ? LEU B 139 MET B 148 
AA5 6  ALA B 114 ? ASN B 122 ? ALA B 114 ASN B 122 
AA5 7  TYR B 85  ? TRP B 94  ? TYR B 85  TRP B 94  
AA5 8  VAL B 68  ? ASN B 71  ? VAL B 68  ASN B 71  
AA5 9  GLN B 58  ? ASN B 63  ? GLN B 58  ASN B 63  
AA5 10 GLU B 171 ? PRO B 175 ? GLU B 171 PRO B 175 
AA6 1  GLU B 47  ? GLN B 49  ? GLU B 47  GLN B 49  
AA6 2  HIS B 77  ? GLN B 79  ? HIS B 77  GLN B 79  
AA6 3  TYR B 85  ? TRP B 94  ? TYR B 85  TRP B 94  
AA6 4  ALA B 114 ? ASN B 122 ? ALA B 114 ASN B 122 
AA6 5  LEU B 139 ? MET B 148 ? LEU B 139 MET B 148 
AA6 6  VAL B 215 ? ILE B 217 ? VAL B 215 ILE B 217 
AA7 1  ASP C 31  ? LEU C 32  ? ASP C 31  LEU C 32  
AA7 2  THR C 106 ? VAL C 107 ? THR C 106 VAL C 107 
AA8 1  LEU C 37  ? TYR C 39  ? LEU C 37  TYR C 39  
AA8 2  VAL C 257 ? THR C 259 ? VAL C 257 THR C 259 
AA8 3  TYR C 190 ? GLY C 195 ? TYR C 190 GLY C 195 
AA8 4  VAL C 206 ? PHE C 211 ? VAL C 206 PHE C 211 
AA8 5  LEU C 139 ? MET C 148 ? LEU C 139 MET C 148 
AA8 6  ALA C 114 ? ASN C 122 ? ALA C 114 ASN C 122 
AA8 7  TYR C 85  ? TRP C 94  ? TYR C 85  TRP C 94  
AA8 8  VAL C 68  ? ASN C 71  ? VAL C 68  ASN C 71  
AA8 9  GLN C 58  ? ASN C 63  ? GLN C 58  ASN C 63  
AA8 10 GLU C 171 ? PRO C 175 ? GLU C 171 PRO C 175 
AA9 1  GLU C 47  ? GLN C 49  ? GLU C 47  GLN C 49  
AA9 2  HIS C 77  ? GLN C 79  ? HIS C 77  GLN C 79  
AA9 3  TYR C 85  ? TRP C 94  ? TYR C 85  TRP C 94  
AA9 4  ALA C 114 ? ASN C 122 ? ALA C 114 ASN C 122 
AA9 5  LEU C 139 ? MET C 148 ? LEU C 139 MET C 148 
AA9 6  VAL C 215 ? ILE C 217 ? VAL C 215 ILE C 217 
AB1 1  ASP D 31  ? LEU D 32  ? ASP D 31  LEU D 32  
AB1 2  THR D 106 ? VAL D 107 ? THR D 106 VAL D 107 
AB2 1  LEU D 37  ? TYR D 39  ? LEU D 37  TYR D 39  
AB2 2  VAL D 257 ? THR D 259 ? VAL D 257 THR D 259 
AB2 3  TYR D 190 ? GLY D 195 ? TYR D 190 GLY D 195 
AB2 4  VAL D 206 ? PHE D 211 ? VAL D 206 PHE D 211 
AB2 5  LEU D 139 ? MET D 148 ? LEU D 139 MET D 148 
AB2 6  ALA D 114 ? ASN D 122 ? ALA D 114 ASN D 122 
AB2 7  TYR D 85  ? TRP D 94  ? TYR D 85  TRP D 94  
AB2 8  VAL D 68  ? ASN D 71  ? VAL D 68  ASN D 71  
AB2 9  GLN D 58  ? ASN D 63  ? GLN D 58  ASN D 63  
AB2 10 GLU D 171 ? PRO D 175 ? GLU D 171 PRO D 175 
AB3 1  GLU D 47  ? GLN D 49  ? GLU D 47  GLN D 49  
AB3 2  HIS D 77  ? GLN D 79  ? HIS D 77  GLN D 79  
AB3 3  TYR D 85  ? TRP D 94  ? TYR D 85  TRP D 94  
AB3 4  ALA D 114 ? ASN D 122 ? ALA D 114 ASN D 122 
AB3 5  LEU D 139 ? MET D 148 ? LEU D 139 MET D 148 
AB3 6  VAL D 215 ? ILE D 217 ? VAL D 215 ILE D 217 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2  N LEU A 32  ? N LEU A 32  O THR A 106 ? O THR A 106 
AA2 1 2  N GLN A 38  ? N GLN A 38  O THR A 259 ? O THR A 259 
AA2 2 3  O TYR A 258 ? O TYR A 258 N ARG A 192 ? N ARG A 192 
AA2 3 4  N GLY A 195 ? N GLY A 195 O VAL A 206 ? O VAL A 206 
AA2 4 5  O THR A 209 ? O THR A 209 N ALA A 143 ? N ALA A 143 
AA2 5 6  O ILE A 146 ? O ILE A 146 N ALA A 114 ? N ALA A 114 
AA2 6 7  O VAL A 119 ? O VAL A 119 N GLN A 89  ? N GLN A 89  
AA2 7 8  O LEU A 90  ? O LEU A 90  N LEU A 70  ? N LEU A 70  
AA2 8 9  O ASN A 71  ? O ASN A 71  N LEU A 60  ? N LEU A 60  
AA2 9 10 N LEU A 61  ? N LEU A 61  O ALA A 172 ? O ALA A 172 
AA3 1 2  N GLN A 49  ? N GLN A 49  O HIS A 77  ? O HIS A 77  
AA3 2 3  N ILE A 78  ? N ILE A 78  O TYR A 85  ? O TYR A 85  
AA3 3 4  N GLN A 89  ? N GLN A 89  O VAL A 119 ? O VAL A 119 
AA3 4 5  N ALA A 114 ? N ALA A 114 O ILE A 146 ? O ILE A 146 
AA3 5 6  N GLU A 147 ? N GLU A 147 O VAL A 215 ? O VAL A 215 
AA4 1 2  N LEU B 32  ? N LEU B 32  O THR B 106 ? O THR B 106 
AA5 1 2  N GLN B 38  ? N GLN B 38  O VAL B 257 ? O VAL B 257 
AA5 2 3  O TYR B 258 ? O TYR B 258 N ARG B 192 ? N ARG B 192 
AA5 3 4  N GLY B 195 ? N GLY B 195 O VAL B 206 ? O VAL B 206 
AA5 4 5  O THR B 209 ? O THR B 209 N ALA B 143 ? N ALA B 143 
AA5 5 6  O ILE B 146 ? O ILE B 146 N ALA B 114 ? N ALA B 114 
AA5 6 7  O VAL B 119 ? O VAL B 119 N GLN B 89  ? N GLN B 89  
AA5 7 8  O LEU B 90  ? O LEU B 90  N LEU B 70  ? N LEU B 70  
AA5 8 9  O ASN B 71  ? O ASN B 71  N LEU B 60  ? N LEU B 60  
AA5 9 10 N LEU B 61  ? N LEU B 61  O ALA B 172 ? O ALA B 172 
AA6 1 2  N GLN B 49  ? N GLN B 49  O HIS B 77  ? O HIS B 77  
AA6 2 3  N ILE B 78  ? N ILE B 78  O TYR B 85  ? O TYR B 85  
AA6 3 4  N GLN B 89  ? N GLN B 89  O VAL B 119 ? O VAL B 119 
AA6 4 5  N ALA B 114 ? N ALA B 114 O ILE B 146 ? O ILE B 146 
AA6 5 6  N GLU B 147 ? N GLU B 147 O VAL B 215 ? O VAL B 215 
AA7 1 2  N LEU C 32  ? N LEU C 32  O THR C 106 ? O THR C 106 
AA8 1 2  N GLN C 38  ? N GLN C 38  O THR C 259 ? O THR C 259 
AA8 2 3  O TYR C 258 ? O TYR C 258 N ARG C 192 ? N ARG C 192 
AA8 3 4  N GLY C 195 ? N GLY C 195 O VAL C 206 ? O VAL C 206 
AA8 4 5  O THR C 209 ? O THR C 209 N ALA C 143 ? N ALA C 143 
AA8 5 6  O VAL C 144 ? O VAL C 144 N LEU C 116 ? N LEU C 116 
AA8 6 7  O VAL C 119 ? O VAL C 119 N GLN C 89  ? N GLN C 89  
AA8 7 8  O LEU C 90  ? O LEU C 90  N LEU C 70  ? N LEU C 70  
AA8 8 9  O ASN C 71  ? O ASN C 71  N LEU C 60  ? N LEU C 60  
AA8 9 10 N LEU C 61  ? N LEU C 61  O ALA C 172 ? O ALA C 172 
AA9 1 2  N GLN C 49  ? N GLN C 49  O HIS C 77  ? O HIS C 77  
AA9 2 3  N ILE C 78  ? N ILE C 78  O TYR C 85  ? O TYR C 85  
AA9 3 4  N GLN C 89  ? N GLN C 89  O VAL C 119 ? O VAL C 119 
AA9 4 5  N LEU C 116 ? N LEU C 116 O VAL C 144 ? O VAL C 144 
AA9 5 6  N GLU C 147 ? N GLU C 147 O VAL C 215 ? O VAL C 215 
AB1 1 2  N LEU D 32  ? N LEU D 32  O THR D 106 ? O THR D 106 
AB2 1 2  N GLN D 38  ? N GLN D 38  O THR D 259 ? O THR D 259 
AB2 2 3  O TYR D 258 ? O TYR D 258 N ARG D 192 ? N ARG D 192 
AB2 3 4  N GLY D 195 ? N GLY D 195 O VAL D 206 ? O VAL D 206 
AB2 4 5  O THR D 209 ? O THR D 209 N ALA D 143 ? N ALA D 143 
AB2 5 6  O VAL D 144 ? O VAL D 144 N LEU D 116 ? N LEU D 116 
AB2 6 7  O HIS D 117 ? O HIS D 117 N HIS D 91  ? N HIS D 91  
AB2 7 8  O LEU D 90  ? O LEU D 90  N LEU D 70  ? N LEU D 70  
AB2 8 9  O ASN D 71  ? O ASN D 71  N LEU D 60  ? N LEU D 60  
AB2 9 10 N LEU D 61  ? N LEU D 61  O ALA D 172 ? O ALA D 172 
AB3 1 2  N GLN D 49  ? N GLN D 49  O HIS D 77  ? O HIS D 77  
AB3 2 3  N ILE D 78  ? N ILE D 78  O TYR D 85  ? O TYR D 85  
AB3 3 4  N HIS D 91  ? N HIS D 91  O HIS D 117 ? O HIS D 117 
AB3 4 5  N LEU D 116 ? N LEU D 116 O VAL D 144 ? O VAL D 144 
AB3 5 6  N GLU D 147 ? N GLU D 147 O VAL D 215 ? O VAL D 215 
# 
loop_
_struct_site.id 
_struct_site.pdbx_evidence_code 
_struct_site.pdbx_auth_asym_id 
_struct_site.pdbx_auth_comp_id 
_struct_site.pdbx_auth_seq_id 
_struct_site.pdbx_auth_ins_code 
_struct_site.pdbx_num_residues 
_struct_site.details 
AC1 Software A ZN  301 ? 4  'binding site for residue ZN A 301'  
AC2 Software A 6Z9 302 ? 16 'binding site for residue 6Z9 A 302' 
AC3 Software B ZN  301 ? 4  'binding site for residue ZN B 301'  
AC4 Software B 6Z9 302 ? 12 'binding site for residue 6Z9 B 302' 
AC5 Software C ZN  301 ? 4  'binding site for residue ZN C 301'  
AC6 Software C 6Z9 302 ? 13 'binding site for residue 6Z9 C 302' 
AC7 Software D ZN  301 ? 4  'binding site for residue ZN D 301'  
AC8 Software D 6Z9 302 ? 14 'binding site for residue 6Z9 D 302' 
# 
loop_
_struct_site_gen.id 
_struct_site_gen.site_id 
_struct_site_gen.pdbx_num_res 
_struct_site_gen.label_comp_id 
_struct_site_gen.label_asym_id 
_struct_site_gen.label_seq_id 
_struct_site_gen.pdbx_auth_ins_code 
_struct_site_gen.auth_comp_id 
_struct_site_gen.auth_asym_id 
_struct_site_gen.auth_seq_id 
_struct_site_gen.label_atom_id 
_struct_site_gen.label_alt_id 
_struct_site_gen.symmetry 
_struct_site_gen.details 
1  AC1 4  HIS A 91  ? HIS A 91  . ? 1_555 ? 
2  AC1 4  HIS A 93  ? HIS A 93  . ? 1_555 ? 
3  AC1 4  HIS A 117 ? HIS A 117 . ? 1_555 ? 
4  AC1 4  6Z9 F .   ? 6Z9 A 302 . ? 1_555 ? 
5  AC2 16 TRP A 4   ? TRP A 4   . ? 1_555 ? 
6  AC2 16 ASN A 64  ? ASN A 64  . ? 1_555 ? 
7  AC2 16 LYS A 69  ? LYS A 69  . ? 1_555 ? 
8  AC2 16 GLN A 89  ? GLN A 89  . ? 1_555 ? 
9  AC2 16 HIS A 91  ? HIS A 91  . ? 1_555 ? 
10 AC2 16 HIS A 93  ? HIS A 93  . ? 1_555 ? 
11 AC2 16 GLU A 104 ? GLU A 104 . ? 1_555 ? 
12 AC2 16 HIS A 117 ? HIS A 117 . ? 1_555 ? 
13 AC2 16 ALA A 129 ? ALA A 129 . ? 1_555 ? 
14 AC2 16 SER A 133 ? SER A 133 . ? 1_555 ? 
15 AC2 16 LEU A 197 ? LEU A 197 . ? 1_555 ? 
16 AC2 16 THR A 198 ? THR A 198 . ? 1_555 ? 
17 AC2 16 THR A 199 ? THR A 199 . ? 1_555 ? 
18 AC2 16 PRO A 200 ? PRO A 200 . ? 1_555 ? 
19 AC2 16 ZN  E .   ? ZN  A 301 . ? 1_555 ? 
20 AC2 16 HOH M .   ? HOH A 623 . ? 1_555 ? 
21 AC3 4  HIS B 91  ? HIS B 91  . ? 1_555 ? 
22 AC3 4  HIS B 93  ? HIS B 93  . ? 1_555 ? 
23 AC3 4  HIS B 117 ? HIS B 117 . ? 1_555 ? 
24 AC3 4  6Z9 H .   ? 6Z9 B 302 . ? 1_555 ? 
25 AC4 12 ASN B 64  ? ASN B 64  . ? 1_555 ? 
26 AC4 12 SER B 67  ? SER B 67  . ? 1_555 ? 
27 AC4 12 HIS B 91  ? HIS B 91  . ? 1_555 ? 
28 AC4 12 HIS B 93  ? HIS B 93  . ? 1_555 ? 
29 AC4 12 HIS B 117 ? HIS B 117 . ? 1_555 ? 
30 AC4 12 ALA B 129 ? ALA B 129 . ? 1_555 ? 
31 AC4 12 LEU B 197 ? LEU B 197 . ? 1_555 ? 
32 AC4 12 THR B 198 ? THR B 198 . ? 1_555 ? 
33 AC4 12 THR B 199 ? THR B 199 . ? 1_555 ? 
34 AC4 12 PRO B 200 ? PRO B 200 . ? 1_555 ? 
35 AC4 12 ZN  G .   ? ZN  B 301 . ? 1_555 ? 
36 AC4 12 HOH N .   ? HOH B 439 . ? 1_555 ? 
37 AC5 4  HIS C 91  ? HIS C 91  . ? 1_555 ? 
38 AC5 4  HIS C 93  ? HIS C 93  . ? 1_555 ? 
39 AC5 4  HIS C 117 ? HIS C 117 . ? 1_555 ? 
40 AC5 4  6Z9 J .   ? 6Z9 C 302 . ? 1_555 ? 
41 AC6 13 ASN C 64  ? ASN C 64  . ? 1_555 ? 
42 AC6 13 LYS C 69  ? LYS C 69  . ? 1_555 ? 
43 AC6 13 GLN C 89  ? GLN C 89  . ? 1_555 ? 
44 AC6 13 HIS C 91  ? HIS C 91  . ? 1_555 ? 
45 AC6 13 HIS C 93  ? HIS C 93  . ? 1_555 ? 
46 AC6 13 GLU C 104 ? GLU C 104 . ? 1_555 ? 
47 AC6 13 HIS C 117 ? HIS C 117 . ? 1_555 ? 
48 AC6 13 ALA C 129 ? ALA C 129 . ? 1_555 ? 
49 AC6 13 LEU C 197 ? LEU C 197 . ? 1_555 ? 
50 AC6 13 THR C 198 ? THR C 198 . ? 1_555 ? 
51 AC6 13 THR C 199 ? THR C 199 . ? 1_555 ? 
52 AC6 13 PRO C 201 ? PRO C 201 . ? 1_555 ? 
53 AC6 13 ZN  I .   ? ZN  C 301 . ? 1_555 ? 
54 AC7 4  HIS D 91  ? HIS D 91  . ? 1_555 ? 
55 AC7 4  HIS D 93  ? HIS D 93  . ? 1_555 ? 
56 AC7 4  HIS D 117 ? HIS D 117 . ? 1_555 ? 
57 AC7 4  6Z9 L .   ? 6Z9 D 302 . ? 1_555 ? 
58 AC8 14 ASN D 64  ? ASN D 64  . ? 1_555 ? 
59 AC8 14 HIS D 91  ? HIS D 91  . ? 1_555 ? 
60 AC8 14 HIS D 93  ? HIS D 93  . ? 1_555 ? 
61 AC8 14 HIS D 117 ? HIS D 117 . ? 1_555 ? 
62 AC8 14 VAL D 119 ? VAL D 119 . ? 1_555 ? 
63 AC8 14 ALA D 129 ? ALA D 129 . ? 1_555 ? 
64 AC8 14 SER D 130 ? SER D 130 . ? 1_555 ? 
65 AC8 14 LEU D 197 ? LEU D 197 . ? 1_555 ? 
66 AC8 14 THR D 198 ? THR D 198 . ? 1_555 ? 
67 AC8 14 THR D 199 ? THR D 199 . ? 1_555 ? 
68 AC8 14 PRO D 200 ? PRO D 200 . ? 1_555 ? 
69 AC8 14 ZN  K .   ? ZN  D 301 . ? 1_555 ? 
70 AC8 14 HOH P .   ? HOH D 406 . ? 1_555 ? 
71 AC8 14 HOH P .   ? HOH D 513 . ? 1_555 ? 
# 
_pdbx_entry_details.entry_id                   5LLP 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 NZ  B LYS 166 ? A O B HOH 401 ? ? 1.77 
2  1 OD1 D ASP 75  ? ? O D HOH 401 ? ? 1.98 
3  1 O   B HOH 590 ? ? O B HOH 624 ? ? 2.06 
4  1 O   D HOH 425 ? ? O D HOH 673 ? ? 2.08 
5  1 O   D HOH 610 ? ? O D HOH 659 ? ? 2.08 
6  1 CD  D ARG 255 ? ? O D HOH 537 ? ? 2.08 
7  1 O   B HOH 490 ? ? O B HOH 644 ? ? 2.09 
8  1 O   D HOH 597 ? ? O D HOH 644 ? ? 2.12 
9  1 OD2 B ASP 253 ? ? O B HOH 402 ? ? 2.19 
10 1 OD1 A ASN 134 ? B O A HOH 401 ? ? 2.19 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     642 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    B 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     641 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   1_655 
_pdbx_validate_symm_contact.dist              2.00 
# 
loop_
_pdbx_validate_rmsd_bond.id 
_pdbx_validate_rmsd_bond.PDB_model_num 
_pdbx_validate_rmsd_bond.auth_atom_id_1 
_pdbx_validate_rmsd_bond.auth_asym_id_1 
_pdbx_validate_rmsd_bond.auth_comp_id_1 
_pdbx_validate_rmsd_bond.auth_seq_id_1 
_pdbx_validate_rmsd_bond.PDB_ins_code_1 
_pdbx_validate_rmsd_bond.label_alt_id_1 
_pdbx_validate_rmsd_bond.auth_atom_id_2 
_pdbx_validate_rmsd_bond.auth_asym_id_2 
_pdbx_validate_rmsd_bond.auth_comp_id_2 
_pdbx_validate_rmsd_bond.auth_seq_id_2 
_pdbx_validate_rmsd_bond.PDB_ins_code_2 
_pdbx_validate_rmsd_bond.label_alt_id_2 
_pdbx_validate_rmsd_bond.bond_value 
_pdbx_validate_rmsd_bond.bond_target_value 
_pdbx_validate_rmsd_bond.bond_deviation 
_pdbx_validate_rmsd_bond.bond_standard_deviation 
_pdbx_validate_rmsd_bond.linker_flag 
1 1 CG A HIS 33  ? ? CD2 A HIS 33  ? ? 1.414 1.354 0.060 0.009 N 
2 1 CG B HIS 161 ? ? CD2 B HIS 161 ? ? 1.409 1.354 0.055 0.009 N 
3 1 CG B HIS 164 ? ? CD2 B HIS 164 ? ? 1.417 1.354 0.063 0.009 N 
4 1 CZ B ARG 255 ? B NH2 B ARG 255 ? B 1.404 1.326 0.078 0.013 N 
5 1 CG C HIS 101 ? ? CD2 C HIS 101 ? ? 1.413 1.354 0.059 0.009 N 
6 1 CG C HIS 117 ? ? CD2 C HIS 117 ? ? 1.421 1.354 0.067 0.009 N 
7 1 CG D HIS 91  ? ? CD2 D HIS 91  ? ? 1.411 1.354 0.057 0.009 N 
8 1 CG D HIS 117 ? ? CD2 D HIS 117 ? ? 1.423 1.354 0.069 0.009 N 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_1             D 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_1              253 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             B 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CG 
_pdbx_validate_rmsd_angle.auth_asym_id_2             D 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_2              253 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             B 
_pdbx_validate_rmsd_angle.auth_atom_id_3             OD1 
_pdbx_validate_rmsd_angle.auth_asym_id_3             D 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_3              253 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             B 
_pdbx_validate_rmsd_angle.angle_value                125.12 
_pdbx_validate_rmsd_angle.angle_target_value         118.30 
_pdbx_validate_rmsd_angle.angle_deviation            6.82 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.90 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASN A 245 ? ? -93.26  56.15  
2  1 ASP B 99  ? ? -157.16 79.99  
3  1 GLN B 163 ? ? -59.01  -7.46  
4  1 SER B 238 ? A -119.26 77.87  
5  1 ASN B 245 ? ? -92.70  59.38  
6  1 GLU B 254 ? ? 73.77   -37.07 
7  1 GLU B 254 ? ? 73.77   -42.58 
8  1 ASN C 245 ? ? -95.02  58.57  
9  1 ASP D 99  ? ? -151.93 80.84  
10 1 SER D 238 ? ? -119.87 75.92  
11 1 ASN D 245 ? ? -95.55  56.97  
12 1 PHE D 252 ? A -102.96 73.36  
13 1 ASP D 253 ? A -23.95  55.02  
14 1 GLU D 254 ? A 81.41   -19.80 
15 1 GLU D 254 ? B 81.34   -46.50 
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   PHE 
_pdbx_validate_peptide_omega.auth_asym_id_1   D 
_pdbx_validate_peptide_omega.auth_seq_id_1    252 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   B 
_pdbx_validate_peptide_omega.auth_comp_id_2   ASP 
_pdbx_validate_peptide_omega.auth_asym_id_2   D 
_pdbx_validate_peptide_omega.auth_seq_id_2    253 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   B 
_pdbx_validate_peptide_omega.omega            -97.79 
# 
_phasing.method   MR 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 691 ? 5.96 . 
2 1 O ? A HOH 692 ? 6.19 . 
3 1 O ? B HOH 706 ? 5.86 . 
4 1 O ? B HOH 707 ? 6.64 . 
5 1 O ? C HOH 668 ? 5.95 . 
6 1 O ? C HOH 669 ? 6.24 . 
7 1 O ? D HOH 716 ? 5.95 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A SER 2   ? A SER 2   
3  1 Y 1 A GLN 263 ? A GLN 263 
4  1 Y 1 B MET 1   ? B MET 1   
5  1 Y 1 B SER 2   ? B SER 2   
6  1 Y 1 C MET 1   ? C MET 1   
7  1 Y 1 C SER 2   ? C SER 2   
8  1 Y 1 C GLN 263 ? C GLN 263 
9  1 Y 1 D MET 1   ? D MET 1   
10 1 Y 1 D SER 2   ? D SER 2   
11 1 Y 1 D GLN 263 ? D GLN 263 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
6Z9 C3   C  Y N 1   
6Z9 C4   C  Y N 2   
6Z9 C8   C  Y N 3   
6Z9 C6   C  Y N 4   
6Z9 C11  C  N N 5   
6Z9 C12  C  N N 6   
6Z9 C15  C  Y N 7   
6Z9 C17  C  N S 8   
6Z9 C18  C  N N 9   
6Z9 C19  C  N N 10  
6Z9 C20  C  N N 11  
6Z9 C21  C  Y N 12  
6Z9 C22  C  Y N 13  
6Z9 C23  C  Y N 14  
6Z9 C24  C  Y N 15  
6Z9 C25  C  Y N 16  
6Z9 C26  C  Y N 17  
6Z9 C27  C  Y N 18  
6Z9 O30  O  N N 19  
6Z9 S2   S  N N 20  
6Z9 O1   O  N N 21  
6Z9 N29  N  N N 22  
6Z9 F28  F  N N 23  
6Z9 S9   S  N N 24  
6Z9 O14  O  N N 25  
6Z9 O13  O  N N 26  
6Z9 O10  O  N N 27  
6Z9 F7   F  N N 28  
6Z9 F5   F  N N 29  
6Z9 N16  N  N N 30  
6Z9 H1   H  N N 31  
6Z9 H2   H  N N 32  
6Z9 H3   H  N N 33  
6Z9 H4   H  N N 34  
6Z9 H5   H  N N 35  
6Z9 H6   H  N N 36  
6Z9 H7   H  N N 37  
6Z9 H8   H  N N 38  
6Z9 H9   H  N N 39  
6Z9 H10  H  N N 40  
6Z9 H11  H  N N 41  
6Z9 H12  H  N N 42  
6Z9 H13  H  N N 43  
6Z9 H14  H  N N 44  
6Z9 H15  H  N N 45  
6Z9 H16  H  N N 46  
6Z9 H17  H  N N 47  
6Z9 H18  H  N N 48  
6Z9 H19  H  N N 49  
ALA N    N  N N 50  
ALA CA   C  N S 51  
ALA C    C  N N 52  
ALA O    O  N N 53  
ALA CB   C  N N 54  
ALA OXT  O  N N 55  
ALA H    H  N N 56  
ALA H2   H  N N 57  
ALA HA   H  N N 58  
ALA HB1  H  N N 59  
ALA HB2  H  N N 60  
ALA HB3  H  N N 61  
ALA HXT  H  N N 62  
ARG N    N  N N 63  
ARG CA   C  N S 64  
ARG C    C  N N 65  
ARG O    O  N N 66  
ARG CB   C  N N 67  
ARG CG   C  N N 68  
ARG CD   C  N N 69  
ARG NE   N  N N 70  
ARG CZ   C  N N 71  
ARG NH1  N  N N 72  
ARG NH2  N  N N 73  
ARG OXT  O  N N 74  
ARG H    H  N N 75  
ARG H2   H  N N 76  
ARG HA   H  N N 77  
ARG HB2  H  N N 78  
ARG HB3  H  N N 79  
ARG HG2  H  N N 80  
ARG HG3  H  N N 81  
ARG HD2  H  N N 82  
ARG HD3  H  N N 83  
ARG HE   H  N N 84  
ARG HH11 H  N N 85  
ARG HH12 H  N N 86  
ARG HH21 H  N N 87  
ARG HH22 H  N N 88  
ARG HXT  H  N N 89  
ASN N    N  N N 90  
ASN CA   C  N S 91  
ASN C    C  N N 92  
ASN O    O  N N 93  
ASN CB   C  N N 94  
ASN CG   C  N N 95  
ASN OD1  O  N N 96  
ASN ND2  N  N N 97  
ASN OXT  O  N N 98  
ASN H    H  N N 99  
ASN H2   H  N N 100 
ASN HA   H  N N 101 
ASN HB2  H  N N 102 
ASN HB3  H  N N 103 
ASN HD21 H  N N 104 
ASN HD22 H  N N 105 
ASN HXT  H  N N 106 
ASP N    N  N N 107 
ASP CA   C  N S 108 
ASP C    C  N N 109 
ASP O    O  N N 110 
ASP CB   C  N N 111 
ASP CG   C  N N 112 
ASP OD1  O  N N 113 
ASP OD2  O  N N 114 
ASP OXT  O  N N 115 
ASP H    H  N N 116 
ASP H2   H  N N 117 
ASP HA   H  N N 118 
ASP HB2  H  N N 119 
ASP HB3  H  N N 120 
ASP HD2  H  N N 121 
ASP HXT  H  N N 122 
CYS N    N  N N 123 
CYS CA   C  N R 124 
CYS C    C  N N 125 
CYS O    O  N N 126 
CYS CB   C  N N 127 
CYS SG   S  N N 128 
CYS OXT  O  N N 129 
CYS H    H  N N 130 
CYS H2   H  N N 131 
CYS HA   H  N N 132 
CYS HB2  H  N N 133 
CYS HB3  H  N N 134 
CYS HG   H  N N 135 
CYS HXT  H  N N 136 
GLN N    N  N N 137 
GLN CA   C  N S 138 
GLN C    C  N N 139 
GLN O    O  N N 140 
GLN CB   C  N N 141 
GLN CG   C  N N 142 
GLN CD   C  N N 143 
GLN OE1  O  N N 144 
GLN NE2  N  N N 145 
GLN OXT  O  N N 146 
GLN H    H  N N 147 
GLN H2   H  N N 148 
GLN HA   H  N N 149 
GLN HB2  H  N N 150 
GLN HB3  H  N N 151 
GLN HG2  H  N N 152 
GLN HG3  H  N N 153 
GLN HE21 H  N N 154 
GLN HE22 H  N N 155 
GLN HXT  H  N N 156 
GLU N    N  N N 157 
GLU CA   C  N S 158 
GLU C    C  N N 159 
GLU O    O  N N 160 
GLU CB   C  N N 161 
GLU CG   C  N N 162 
GLU CD   C  N N 163 
GLU OE1  O  N N 164 
GLU OE2  O  N N 165 
GLU OXT  O  N N 166 
GLU H    H  N N 167 
GLU H2   H  N N 168 
GLU HA   H  N N 169 
GLU HB2  H  N N 170 
GLU HB3  H  N N 171 
GLU HG2  H  N N 172 
GLU HG3  H  N N 173 
GLU HE2  H  N N 174 
GLU HXT  H  N N 175 
GLY N    N  N N 176 
GLY CA   C  N N 177 
GLY C    C  N N 178 
GLY O    O  N N 179 
GLY OXT  O  N N 180 
GLY H    H  N N 181 
GLY H2   H  N N 182 
GLY HA2  H  N N 183 
GLY HA3  H  N N 184 
GLY HXT  H  N N 185 
HIS N    N  N N 186 
HIS CA   C  N S 187 
HIS C    C  N N 188 
HIS O    O  N N 189 
HIS CB   C  N N 190 
HIS CG   C  Y N 191 
HIS ND1  N  Y N 192 
HIS CD2  C  Y N 193 
HIS CE1  C  Y N 194 
HIS NE2  N  Y N 195 
HIS OXT  O  N N 196 
HIS H    H  N N 197 
HIS H2   H  N N 198 
HIS HA   H  N N 199 
HIS HB2  H  N N 200 
HIS HB3  H  N N 201 
HIS HD1  H  N N 202 
HIS HD2  H  N N 203 
HIS HE1  H  N N 204 
HIS HE2  H  N N 205 
HIS HXT  H  N N 206 
HOH O    O  N N 207 
HOH H1   H  N N 208 
HOH H2   H  N N 209 
ILE N    N  N N 210 
ILE CA   C  N S 211 
ILE C    C  N N 212 
ILE O    O  N N 213 
ILE CB   C  N S 214 
ILE CG1  C  N N 215 
ILE CG2  C  N N 216 
ILE CD1  C  N N 217 
ILE OXT  O  N N 218 
ILE H    H  N N 219 
ILE H2   H  N N 220 
ILE HA   H  N N 221 
ILE HB   H  N N 222 
ILE HG12 H  N N 223 
ILE HG13 H  N N 224 
ILE HG21 H  N N 225 
ILE HG22 H  N N 226 
ILE HG23 H  N N 227 
ILE HD11 H  N N 228 
ILE HD12 H  N N 229 
ILE HD13 H  N N 230 
ILE HXT  H  N N 231 
LEU N    N  N N 232 
LEU CA   C  N S 233 
LEU C    C  N N 234 
LEU O    O  N N 235 
LEU CB   C  N N 236 
LEU CG   C  N N 237 
LEU CD1  C  N N 238 
LEU CD2  C  N N 239 
LEU OXT  O  N N 240 
LEU H    H  N N 241 
LEU H2   H  N N 242 
LEU HA   H  N N 243 
LEU HB2  H  N N 244 
LEU HB3  H  N N 245 
LEU HG   H  N N 246 
LEU HD11 H  N N 247 
LEU HD12 H  N N 248 
LEU HD13 H  N N 249 
LEU HD21 H  N N 250 
LEU HD22 H  N N 251 
LEU HD23 H  N N 252 
LEU HXT  H  N N 253 
LYS N    N  N N 254 
LYS CA   C  N S 255 
LYS C    C  N N 256 
LYS O    O  N N 257 
LYS CB   C  N N 258 
LYS CG   C  N N 259 
LYS CD   C  N N 260 
LYS CE   C  N N 261 
LYS NZ   N  N N 262 
LYS OXT  O  N N 263 
LYS H    H  N N 264 
LYS H2   H  N N 265 
LYS HA   H  N N 266 
LYS HB2  H  N N 267 
LYS HB3  H  N N 268 
LYS HG2  H  N N 269 
LYS HG3  H  N N 270 
LYS HD2  H  N N 271 
LYS HD3  H  N N 272 
LYS HE2  H  N N 273 
LYS HE3  H  N N 274 
LYS HZ1  H  N N 275 
LYS HZ2  H  N N 276 
LYS HZ3  H  N N 277 
LYS HXT  H  N N 278 
MET N    N  N N 279 
MET CA   C  N S 280 
MET C    C  N N 281 
MET O    O  N N 282 
MET CB   C  N N 283 
MET CG   C  N N 284 
MET SD   S  N N 285 
MET CE   C  N N 286 
MET OXT  O  N N 287 
MET H    H  N N 288 
MET H2   H  N N 289 
MET HA   H  N N 290 
MET HB2  H  N N 291 
MET HB3  H  N N 292 
MET HG2  H  N N 293 
MET HG3  H  N N 294 
MET HE1  H  N N 295 
MET HE2  H  N N 296 
MET HE3  H  N N 297 
MET HXT  H  N N 298 
PHE N    N  N N 299 
PHE CA   C  N S 300 
PHE C    C  N N 301 
PHE O    O  N N 302 
PHE CB   C  N N 303 
PHE CG   C  Y N 304 
PHE CD1  C  Y N 305 
PHE CD2  C  Y N 306 
PHE CE1  C  Y N 307 
PHE CE2  C  Y N 308 
PHE CZ   C  Y N 309 
PHE OXT  O  N N 310 
PHE H    H  N N 311 
PHE H2   H  N N 312 
PHE HA   H  N N 313 
PHE HB2  H  N N 314 
PHE HB3  H  N N 315 
PHE HD1  H  N N 316 
PHE HD2  H  N N 317 
PHE HE1  H  N N 318 
PHE HE2  H  N N 319 
PHE HZ   H  N N 320 
PHE HXT  H  N N 321 
PRO N    N  N N 322 
PRO CA   C  N S 323 
PRO C    C  N N 324 
PRO O    O  N N 325 
PRO CB   C  N N 326 
PRO CG   C  N N 327 
PRO CD   C  N N 328 
PRO OXT  O  N N 329 
PRO H    H  N N 330 
PRO HA   H  N N 331 
PRO HB2  H  N N 332 
PRO HB3  H  N N 333 
PRO HG2  H  N N 334 
PRO HG3  H  N N 335 
PRO HD2  H  N N 336 
PRO HD3  H  N N 337 
PRO HXT  H  N N 338 
SER N    N  N N 339 
SER CA   C  N S 340 
SER C    C  N N 341 
SER O    O  N N 342 
SER CB   C  N N 343 
SER OG   O  N N 344 
SER OXT  O  N N 345 
SER H    H  N N 346 
SER H2   H  N N 347 
SER HA   H  N N 348 
SER HB2  H  N N 349 
SER HB3  H  N N 350 
SER HG   H  N N 351 
SER HXT  H  N N 352 
THR N    N  N N 353 
THR CA   C  N S 354 
THR C    C  N N 355 
THR O    O  N N 356 
THR CB   C  N R 357 
THR OG1  O  N N 358 
THR CG2  C  N N 359 
THR OXT  O  N N 360 
THR H    H  N N 361 
THR H2   H  N N 362 
THR HA   H  N N 363 
THR HB   H  N N 364 
THR HG1  H  N N 365 
THR HG21 H  N N 366 
THR HG22 H  N N 367 
THR HG23 H  N N 368 
THR HXT  H  N N 369 
TRP N    N  N N 370 
TRP CA   C  N S 371 
TRP C    C  N N 372 
TRP O    O  N N 373 
TRP CB   C  N N 374 
TRP CG   C  Y N 375 
TRP CD1  C  Y N 376 
TRP CD2  C  Y N 377 
TRP NE1  N  Y N 378 
TRP CE2  C  Y N 379 
TRP CE3  C  Y N 380 
TRP CZ2  C  Y N 381 
TRP CZ3  C  Y N 382 
TRP CH2  C  Y N 383 
TRP OXT  O  N N 384 
TRP H    H  N N 385 
TRP H2   H  N N 386 
TRP HA   H  N N 387 
TRP HB2  H  N N 388 
TRP HB3  H  N N 389 
TRP HD1  H  N N 390 
TRP HE1  H  N N 391 
TRP HE3  H  N N 392 
TRP HZ2  H  N N 393 
TRP HZ3  H  N N 394 
TRP HH2  H  N N 395 
TRP HXT  H  N N 396 
TYR N    N  N N 397 
TYR CA   C  N S 398 
TYR C    C  N N 399 
TYR O    O  N N 400 
TYR CB   C  N N 401 
TYR CG   C  Y N 402 
TYR CD1  C  Y N 403 
TYR CD2  C  Y N 404 
TYR CE1  C  Y N 405 
TYR CE2  C  Y N 406 
TYR CZ   C  Y N 407 
TYR OH   O  N N 408 
TYR OXT  O  N N 409 
TYR H    H  N N 410 
TYR H2   H  N N 411 
TYR HA   H  N N 412 
TYR HB2  H  N N 413 
TYR HB3  H  N N 414 
TYR HD1  H  N N 415 
TYR HD2  H  N N 416 
TYR HE1  H  N N 417 
TYR HE2  H  N N 418 
TYR HH   H  N N 419 
TYR HXT  H  N N 420 
VAL N    N  N N 421 
VAL CA   C  N S 422 
VAL C    C  N N 423 
VAL O    O  N N 424 
VAL CB   C  N N 425 
VAL CG1  C  N N 426 
VAL CG2  C  N N 427 
VAL OXT  O  N N 428 
VAL H    H  N N 429 
VAL H2   H  N N 430 
VAL HA   H  N N 431 
VAL HB   H  N N 432 
VAL HG11 H  N N 433 
VAL HG12 H  N N 434 
VAL HG13 H  N N 435 
VAL HG21 H  N N 436 
VAL HG22 H  N N 437 
VAL HG23 H  N N 438 
VAL HXT  H  N N 439 
ZN  ZN   ZN N N 440 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
6Z9 O1  S2   doub N N 1   
6Z9 C25 C24  doub Y N 2   
6Z9 C25 C26  sing Y N 3   
6Z9 C24 C23  sing Y N 4   
6Z9 C26 C21  doub Y N 5   
6Z9 C23 C22  doub Y N 6   
6Z9 O30 S2   doub N N 7   
6Z9 C21 C22  sing Y N 8   
6Z9 C21 C20  sing N N 9   
6Z9 F28 C27  sing N N 10  
6Z9 C22 C17  sing N N 11  
6Z9 C20 C19  sing N N 12  
6Z9 S2  N29  sing N N 13  
6Z9 S2  C3   sing N N 14  
6Z9 C17 C18  sing N N 15  
6Z9 C17 N16  sing N N 16  
6Z9 C18 C19  sing N N 17  
6Z9 C27 C3   doub Y N 18  
6Z9 C27 C15  sing Y N 19  
6Z9 C3  C4   sing Y N 20  
6Z9 N16 C15  sing N N 21  
6Z9 C15 C8   doub Y N 22  
6Z9 C4  F5   sing N N 23  
6Z9 C4  C6   doub Y N 24  
6Z9 C8  C6   sing Y N 25  
6Z9 C8  S9   sing N N 26  
6Z9 C6  F7   sing N N 27  
6Z9 O14 S9   doub N N 28  
6Z9 O10 S9   doub N N 29  
6Z9 S9  C11  sing N N 30  
6Z9 O13 C12  sing N N 31  
6Z9 C12 C11  sing N N 32  
6Z9 C11 H1   sing N N 33  
6Z9 C11 H2   sing N N 34  
6Z9 C12 H3   sing N N 35  
6Z9 C12 H4   sing N N 36  
6Z9 C17 H5   sing N N 37  
6Z9 C18 H6   sing N N 38  
6Z9 C18 H7   sing N N 39  
6Z9 C19 H8   sing N N 40  
6Z9 C19 H9   sing N N 41  
6Z9 C20 H10  sing N N 42  
6Z9 C20 H11  sing N N 43  
6Z9 C23 H12  sing N N 44  
6Z9 C24 H13  sing N N 45  
6Z9 C25 H14  sing N N 46  
6Z9 C26 H15  sing N N 47  
6Z9 N29 H16  sing N N 48  
6Z9 N29 H17  sing N N 49  
6Z9 O13 H18  sing N N 50  
6Z9 N16 H19  sing N N 51  
ALA N   CA   sing N N 52  
ALA N   H    sing N N 53  
ALA N   H2   sing N N 54  
ALA CA  C    sing N N 55  
ALA CA  CB   sing N N 56  
ALA CA  HA   sing N N 57  
ALA C   O    doub N N 58  
ALA C   OXT  sing N N 59  
ALA CB  HB1  sing N N 60  
ALA CB  HB2  sing N N 61  
ALA CB  HB3  sing N N 62  
ALA OXT HXT  sing N N 63  
ARG N   CA   sing N N 64  
ARG N   H    sing N N 65  
ARG N   H2   sing N N 66  
ARG CA  C    sing N N 67  
ARG CA  CB   sing N N 68  
ARG CA  HA   sing N N 69  
ARG C   O    doub N N 70  
ARG C   OXT  sing N N 71  
ARG CB  CG   sing N N 72  
ARG CB  HB2  sing N N 73  
ARG CB  HB3  sing N N 74  
ARG CG  CD   sing N N 75  
ARG CG  HG2  sing N N 76  
ARG CG  HG3  sing N N 77  
ARG CD  NE   sing N N 78  
ARG CD  HD2  sing N N 79  
ARG CD  HD3  sing N N 80  
ARG NE  CZ   sing N N 81  
ARG NE  HE   sing N N 82  
ARG CZ  NH1  sing N N 83  
ARG CZ  NH2  doub N N 84  
ARG NH1 HH11 sing N N 85  
ARG NH1 HH12 sing N N 86  
ARG NH2 HH21 sing N N 87  
ARG NH2 HH22 sing N N 88  
ARG OXT HXT  sing N N 89  
ASN N   CA   sing N N 90  
ASN N   H    sing N N 91  
ASN N   H2   sing N N 92  
ASN CA  C    sing N N 93  
ASN CA  CB   sing N N 94  
ASN CA  HA   sing N N 95  
ASN C   O    doub N N 96  
ASN C   OXT  sing N N 97  
ASN CB  CG   sing N N 98  
ASN CB  HB2  sing N N 99  
ASN CB  HB3  sing N N 100 
ASN CG  OD1  doub N N 101 
ASN CG  ND2  sing N N 102 
ASN ND2 HD21 sing N N 103 
ASN ND2 HD22 sing N N 104 
ASN OXT HXT  sing N N 105 
ASP N   CA   sing N N 106 
ASP N   H    sing N N 107 
ASP N   H2   sing N N 108 
ASP CA  C    sing N N 109 
ASP CA  CB   sing N N 110 
ASP CA  HA   sing N N 111 
ASP C   O    doub N N 112 
ASP C   OXT  sing N N 113 
ASP CB  CG   sing N N 114 
ASP CB  HB2  sing N N 115 
ASP CB  HB3  sing N N 116 
ASP CG  OD1  doub N N 117 
ASP CG  OD2  sing N N 118 
ASP OD2 HD2  sing N N 119 
ASP OXT HXT  sing N N 120 
CYS N   CA   sing N N 121 
CYS N   H    sing N N 122 
CYS N   H2   sing N N 123 
CYS CA  C    sing N N 124 
CYS CA  CB   sing N N 125 
CYS CA  HA   sing N N 126 
CYS C   O    doub N N 127 
CYS C   OXT  sing N N 128 
CYS CB  SG   sing N N 129 
CYS CB  HB2  sing N N 130 
CYS CB  HB3  sing N N 131 
CYS SG  HG   sing N N 132 
CYS OXT HXT  sing N N 133 
GLN N   CA   sing N N 134 
GLN N   H    sing N N 135 
GLN N   H2   sing N N 136 
GLN CA  C    sing N N 137 
GLN CA  CB   sing N N 138 
GLN CA  HA   sing N N 139 
GLN C   O    doub N N 140 
GLN C   OXT  sing N N 141 
GLN CB  CG   sing N N 142 
GLN CB  HB2  sing N N 143 
GLN CB  HB3  sing N N 144 
GLN CG  CD   sing N N 145 
GLN CG  HG2  sing N N 146 
GLN CG  HG3  sing N N 147 
GLN CD  OE1  doub N N 148 
GLN CD  NE2  sing N N 149 
GLN NE2 HE21 sing N N 150 
GLN NE2 HE22 sing N N 151 
GLN OXT HXT  sing N N 152 
GLU N   CA   sing N N 153 
GLU N   H    sing N N 154 
GLU N   H2   sing N N 155 
GLU CA  C    sing N N 156 
GLU CA  CB   sing N N 157 
GLU CA  HA   sing N N 158 
GLU C   O    doub N N 159 
GLU C   OXT  sing N N 160 
GLU CB  CG   sing N N 161 
GLU CB  HB2  sing N N 162 
GLU CB  HB3  sing N N 163 
GLU CG  CD   sing N N 164 
GLU CG  HG2  sing N N 165 
GLU CG  HG3  sing N N 166 
GLU CD  OE1  doub N N 167 
GLU CD  OE2  sing N N 168 
GLU OE2 HE2  sing N N 169 
GLU OXT HXT  sing N N 170 
GLY N   CA   sing N N 171 
GLY N   H    sing N N 172 
GLY N   H2   sing N N 173 
GLY CA  C    sing N N 174 
GLY CA  HA2  sing N N 175 
GLY CA  HA3  sing N N 176 
GLY C   O    doub N N 177 
GLY C   OXT  sing N N 178 
GLY OXT HXT  sing N N 179 
HIS N   CA   sing N N 180 
HIS N   H    sing N N 181 
HIS N   H2   sing N N 182 
HIS CA  C    sing N N 183 
HIS CA  CB   sing N N 184 
HIS CA  HA   sing N N 185 
HIS C   O    doub N N 186 
HIS C   OXT  sing N N 187 
HIS CB  CG   sing N N 188 
HIS CB  HB2  sing N N 189 
HIS CB  HB3  sing N N 190 
HIS CG  ND1  sing Y N 191 
HIS CG  CD2  doub Y N 192 
HIS ND1 CE1  doub Y N 193 
HIS ND1 HD1  sing N N 194 
HIS CD2 NE2  sing Y N 195 
HIS CD2 HD2  sing N N 196 
HIS CE1 NE2  sing Y N 197 
HIS CE1 HE1  sing N N 198 
HIS NE2 HE2  sing N N 199 
HIS OXT HXT  sing N N 200 
HOH O   H1   sing N N 201 
HOH O   H2   sing N N 202 
ILE N   CA   sing N N 203 
ILE N   H    sing N N 204 
ILE N   H2   sing N N 205 
ILE CA  C    sing N N 206 
ILE CA  CB   sing N N 207 
ILE CA  HA   sing N N 208 
ILE C   O    doub N N 209 
ILE C   OXT  sing N N 210 
ILE CB  CG1  sing N N 211 
ILE CB  CG2  sing N N 212 
ILE CB  HB   sing N N 213 
ILE CG1 CD1  sing N N 214 
ILE CG1 HG12 sing N N 215 
ILE CG1 HG13 sing N N 216 
ILE CG2 HG21 sing N N 217 
ILE CG2 HG22 sing N N 218 
ILE CG2 HG23 sing N N 219 
ILE CD1 HD11 sing N N 220 
ILE CD1 HD12 sing N N 221 
ILE CD1 HD13 sing N N 222 
ILE OXT HXT  sing N N 223 
LEU N   CA   sing N N 224 
LEU N   H    sing N N 225 
LEU N   H2   sing N N 226 
LEU CA  C    sing N N 227 
LEU CA  CB   sing N N 228 
LEU CA  HA   sing N N 229 
LEU C   O    doub N N 230 
LEU C   OXT  sing N N 231 
LEU CB  CG   sing N N 232 
LEU CB  HB2  sing N N 233 
LEU CB  HB3  sing N N 234 
LEU CG  CD1  sing N N 235 
LEU CG  CD2  sing N N 236 
LEU CG  HG   sing N N 237 
LEU CD1 HD11 sing N N 238 
LEU CD1 HD12 sing N N 239 
LEU CD1 HD13 sing N N 240 
LEU CD2 HD21 sing N N 241 
LEU CD2 HD22 sing N N 242 
LEU CD2 HD23 sing N N 243 
LEU OXT HXT  sing N N 244 
LYS N   CA   sing N N 245 
LYS N   H    sing N N 246 
LYS N   H2   sing N N 247 
LYS CA  C    sing N N 248 
LYS CA  CB   sing N N 249 
LYS CA  HA   sing N N 250 
LYS C   O    doub N N 251 
LYS C   OXT  sing N N 252 
LYS CB  CG   sing N N 253 
LYS CB  HB2  sing N N 254 
LYS CB  HB3  sing N N 255 
LYS CG  CD   sing N N 256 
LYS CG  HG2  sing N N 257 
LYS CG  HG3  sing N N 258 
LYS CD  CE   sing N N 259 
LYS CD  HD2  sing N N 260 
LYS CD  HD3  sing N N 261 
LYS CE  NZ   sing N N 262 
LYS CE  HE2  sing N N 263 
LYS CE  HE3  sing N N 264 
LYS NZ  HZ1  sing N N 265 
LYS NZ  HZ2  sing N N 266 
LYS NZ  HZ3  sing N N 267 
LYS OXT HXT  sing N N 268 
MET N   CA   sing N N 269 
MET N   H    sing N N 270 
MET N   H2   sing N N 271 
MET CA  C    sing N N 272 
MET CA  CB   sing N N 273 
MET CA  HA   sing N N 274 
MET C   O    doub N N 275 
MET C   OXT  sing N N 276 
MET CB  CG   sing N N 277 
MET CB  HB2  sing N N 278 
MET CB  HB3  sing N N 279 
MET CG  SD   sing N N 280 
MET CG  HG2  sing N N 281 
MET CG  HG3  sing N N 282 
MET SD  CE   sing N N 283 
MET CE  HE1  sing N N 284 
MET CE  HE2  sing N N 285 
MET CE  HE3  sing N N 286 
MET OXT HXT  sing N N 287 
PHE N   CA   sing N N 288 
PHE N   H    sing N N 289 
PHE N   H2   sing N N 290 
PHE CA  C    sing N N 291 
PHE CA  CB   sing N N 292 
PHE CA  HA   sing N N 293 
PHE C   O    doub N N 294 
PHE C   OXT  sing N N 295 
PHE CB  CG   sing N N 296 
PHE CB  HB2  sing N N 297 
PHE CB  HB3  sing N N 298 
PHE CG  CD1  doub Y N 299 
PHE CG  CD2  sing Y N 300 
PHE CD1 CE1  sing Y N 301 
PHE CD1 HD1  sing N N 302 
PHE CD2 CE2  doub Y N 303 
PHE CD2 HD2  sing N N 304 
PHE CE1 CZ   doub Y N 305 
PHE CE1 HE1  sing N N 306 
PHE CE2 CZ   sing Y N 307 
PHE CE2 HE2  sing N N 308 
PHE CZ  HZ   sing N N 309 
PHE OXT HXT  sing N N 310 
PRO N   CA   sing N N 311 
PRO N   CD   sing N N 312 
PRO N   H    sing N N 313 
PRO CA  C    sing N N 314 
PRO CA  CB   sing N N 315 
PRO CA  HA   sing N N 316 
PRO C   O    doub N N 317 
PRO C   OXT  sing N N 318 
PRO CB  CG   sing N N 319 
PRO CB  HB2  sing N N 320 
PRO CB  HB3  sing N N 321 
PRO CG  CD   sing N N 322 
PRO CG  HG2  sing N N 323 
PRO CG  HG3  sing N N 324 
PRO CD  HD2  sing N N 325 
PRO CD  HD3  sing N N 326 
PRO OXT HXT  sing N N 327 
SER N   CA   sing N N 328 
SER N   H    sing N N 329 
SER N   H2   sing N N 330 
SER CA  C    sing N N 331 
SER CA  CB   sing N N 332 
SER CA  HA   sing N N 333 
SER C   O    doub N N 334 
SER C   OXT  sing N N 335 
SER CB  OG   sing N N 336 
SER CB  HB2  sing N N 337 
SER CB  HB3  sing N N 338 
SER OG  HG   sing N N 339 
SER OXT HXT  sing N N 340 
THR N   CA   sing N N 341 
THR N   H    sing N N 342 
THR N   H2   sing N N 343 
THR CA  C    sing N N 344 
THR CA  CB   sing N N 345 
THR CA  HA   sing N N 346 
THR C   O    doub N N 347 
THR C   OXT  sing N N 348 
THR CB  OG1  sing N N 349 
THR CB  CG2  sing N N 350 
THR CB  HB   sing N N 351 
THR OG1 HG1  sing N N 352 
THR CG2 HG21 sing N N 353 
THR CG2 HG22 sing N N 354 
THR CG2 HG23 sing N N 355 
THR OXT HXT  sing N N 356 
TRP N   CA   sing N N 357 
TRP N   H    sing N N 358 
TRP N   H2   sing N N 359 
TRP CA  C    sing N N 360 
TRP CA  CB   sing N N 361 
TRP CA  HA   sing N N 362 
TRP C   O    doub N N 363 
TRP C   OXT  sing N N 364 
TRP CB  CG   sing N N 365 
TRP CB  HB2  sing N N 366 
TRP CB  HB3  sing N N 367 
TRP CG  CD1  doub Y N 368 
TRP CG  CD2  sing Y N 369 
TRP CD1 NE1  sing Y N 370 
TRP CD1 HD1  sing N N 371 
TRP CD2 CE2  doub Y N 372 
TRP CD2 CE3  sing Y N 373 
TRP NE1 CE2  sing Y N 374 
TRP NE1 HE1  sing N N 375 
TRP CE2 CZ2  sing Y N 376 
TRP CE3 CZ3  doub Y N 377 
TRP CE3 HE3  sing N N 378 
TRP CZ2 CH2  doub Y N 379 
TRP CZ2 HZ2  sing N N 380 
TRP CZ3 CH2  sing Y N 381 
TRP CZ3 HZ3  sing N N 382 
TRP CH2 HH2  sing N N 383 
TRP OXT HXT  sing N N 384 
TYR N   CA   sing N N 385 
TYR N   H    sing N N 386 
TYR N   H2   sing N N 387 
TYR CA  C    sing N N 388 
TYR CA  CB   sing N N 389 
TYR CA  HA   sing N N 390 
TYR C   O    doub N N 391 
TYR C   OXT  sing N N 392 
TYR CB  CG   sing N N 393 
TYR CB  HB2  sing N N 394 
TYR CB  HB3  sing N N 395 
TYR CG  CD1  doub Y N 396 
TYR CG  CD2  sing Y N 397 
TYR CD1 CE1  sing Y N 398 
TYR CD1 HD1  sing N N 399 
TYR CD2 CE2  doub Y N 400 
TYR CD2 HD2  sing N N 401 
TYR CE1 CZ   doub Y N 402 
TYR CE1 HE1  sing N N 403 
TYR CE2 CZ   sing Y N 404 
TYR CE2 HE2  sing N N 405 
TYR CZ  OH   sing N N 406 
TYR OH  HH   sing N N 407 
TYR OXT HXT  sing N N 408 
VAL N   CA   sing N N 409 
VAL N   H    sing N N 410 
VAL N   H2   sing N N 411 
VAL CA  C    sing N N 412 
VAL CA  CB   sing N N 413 
VAL CA  HA   sing N N 414 
VAL C   O    doub N N 415 
VAL C   OXT  sing N N 416 
VAL CB  CG1  sing N N 417 
VAL CB  CG2  sing N N 418 
VAL CB  HB   sing N N 419 
VAL CG1 HG11 sing N N 420 
VAL CG1 HG12 sing N N 421 
VAL CG1 HG13 sing N N 422 
VAL CG2 HG21 sing N N 423 
VAL CG2 HG22 sing N N 424 
VAL CG2 HG23 sing N N 425 
VAL OXT HXT  sing N N 426 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1JD0 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    5LLP 
_atom_sites.fract_transf_matrix[1][1]   0.012905 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.004436 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013461 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011537 
_atom_sites.fract_transf_vector[1]      0.000000 
_atom_sites.fract_transf_vector[2]      0.000000 
_atom_sites.fract_transf_vector[3]      0.000000 
# 
loop_
_atom_type.symbol 
C  
F  
N  
O  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . LYS A 1 3   ? 18.679  16.044  18.987  1.00 42.39 ? 3   LYS A N   1 
ATOM   2    C  CA  . LYS A 1 3   ? 17.371  16.338  18.313  1.00 37.79 ? 3   LYS A CA  1 
ATOM   3    C  C   . LYS A 1 3   ? 16.564  15.034  18.063  1.00 31.76 ? 3   LYS A C   1 
ATOM   4    O  O   . LYS A 1 3   ? 15.607  14.744  18.791  1.00 34.53 ? 3   LYS A O   1 
ATOM   5    C  CB  . LYS A 1 3   ? 17.595  17.149  17.007  1.00 44.94 ? 3   LYS A CB  1 
ATOM   6    C  CG  . LYS A 1 3   ? 18.899  16.850  16.243  1.00 42.70 ? 3   LYS A CG  1 
ATOM   7    C  CD  . LYS A 1 3   ? 20.111  17.523  16.918  1.00 45.87 ? 3   LYS A CD  1 
ATOM   8    C  CE  . LYS A 1 3   ? 21.393  16.715  16.798  1.00 47.13 ? 3   LYS A CE  1 
ATOM   9    N  NZ  . LYS A 1 3   ? 21.207  15.287  17.216  1.00 44.46 ? 3   LYS A NZ  1 
ATOM   10   N  N   . TRP A 1 4   ? 17.005  14.219  17.105  1.00 22.13 ? 4   TRP A N   1 
ATOM   11   C  CA  . TRP A 1 4   ? 16.165  13.111  16.635  1.00 16.84 ? 4   TRP A CA  1 
ATOM   12   C  C   . TRP A 1 4   ? 16.198  11.930  17.578  1.00 15.80 ? 4   TRP A C   1 
ATOM   13   O  O   . TRP A 1 4   ? 17.162  11.697  18.358  1.00 14.84 ? 4   TRP A O   1 
ATOM   14   C  CB  . TRP A 1 4   ? 16.635  12.661  15.296  1.00 14.84 ? 4   TRP A CB  1 
ATOM   15   C  CG  . TRP A 1 4   ? 17.986  12.011  15.253  1.00 12.86 ? 4   TRP A CG  1 
ATOM   16   C  CD1 . TRP A 1 4   ? 19.178  12.606  15.000  1.00 13.06 ? 4   TRP A CD1 1 
ATOM   17   C  CD2 . TRP A 1 4   ? 18.298  10.575  15.342  1.00 11.95 ? 4   TRP A CD2 1 
ATOM   18   N  NE1 . TRP A 1 4   ? 20.201  11.722  14.976  1.00 13.60 ? 4   TRP A NE1 1 
ATOM   19   C  CE2 . TRP A 1 4   ? 19.726  10.417  15.203  1.00 12.33 ? 4   TRP A CE2 1 
ATOM   20   C  CE3 . TRP A 1 4   ? 17.513  9.450   15.591  1.00 10.72 ? 4   TRP A CE3 1 
ATOM   21   C  CZ2 . TRP A 1 4   ? 20.358  9.135   15.216  1.00 11.01 ? 4   TRP A CZ2 1 
ATOM   22   C  CZ3 . TRP A 1 4   ? 18.153  8.178   15.599  1.00 10.11 ? 4   TRP A CZ3 1 
ATOM   23   C  CH2 . TRP A 1 4   ? 19.545  8.029   15.445  1.00 9.87  ? 4   TRP A CH2 1 
ATOM   24   N  N   . THR A 1 5   ? 15.112  11.194  17.549  1.00 14.28 ? 5   THR A N   1 
ATOM   25   C  CA  . THR A 1 5   ? 14.943  10.030  18.477  1.00 13.62 ? 5   THR A CA  1 
ATOM   26   C  C   . THR A 1 5   ? 14.199  8.905   17.700  1.00 11.31 ? 5   THR A C   1 
ATOM   27   O  O   . THR A 1 5   ? 13.897  9.069   16.492  1.00 10.49 ? 5   THR A O   1 
ATOM   28   C  CB  . THR A 1 5   ? 14.005  10.334  19.623  1.00 16.51 ? 5   THR A CB  1 
ATOM   29   O  OG1 . THR A 1 5   ? 12.696  10.614  19.050  1.00 18.25 ? 5   THR A OG1 1 
ATOM   30   C  CG2 . THR A 1 5   ? 14.561  11.586  20.422  1.00 17.86 ? 5   THR A CG2 1 
ATOM   31   N  N   . TYR A 1 6   ? 13.907  7.770   18.341  1.00 12.42 ? 6   TYR A N   1 
ATOM   32   C  CA  . TYR A 1 6   ? 13.092  6.733   17.751  1.00 11.69 ? 6   TYR A CA  1 
ATOM   33   C  C   . TYR A 1 6   ? 11.662  6.667   18.247  1.00 11.86 ? 6   TYR A C   1 
ATOM   34   O  O   . TYR A 1 6   ? 10.858  5.730   18.003  1.00 14.13 ? 6   TYR A O   1 
ATOM   35   C  CB  . TYR A 1 6   ? 13.728  5.346   17.982  1.00 11.02 ? 6   TYR A CB  1 
ATOM   36   C  CG  . TYR A 1 6   ? 15.002  5.116   17.226  1.00 10.81 ? 6   TYR A CG  1 
ATOM   37   C  CD1 . TYR A 1 6   ? 16.229  5.365   17.830  1.00 10.94 ? 6   TYR A CD1 1 
ATOM   38   C  CD2 . TYR A 1 6   ? 14.977  4.583   15.940  1.00 9.75  ? 6   TYR A CD2 1 
ATOM   39   C  CE1 . TYR A 1 6   ? 17.405  5.053   17.216  1.00 10.37 ? 6   TYR A CE1 1 
ATOM   40   C  CE2 . TYR A 1 6   ? 16.131  4.285   15.256  1.00 10.45 ? 6   TYR A CE2 1 
ATOM   41   C  CZ  . TYR A 1 6   ? 17.321  4.496   15.906  1.00 10.36 ? 6   TYR A CZ  1 
ATOM   42   O  OH  . TYR A 1 6   ? 18.419  4.160   15.214  1.00 12.03 ? 6   TYR A OH  1 
ATOM   43   N  N   . PHE A 1 7   ? 11.293  7.677   19.027  1.00 19.12 ? 7   PHE A N   1 
ATOM   44   C  CA  . PHE A 1 7   ? 9.929   7.742   19.558  1.00 25.87 ? 7   PHE A CA  1 
ATOM   45   C  C   . PHE A 1 7   ? 9.387   9.174   19.520  1.00 30.38 ? 7   PHE A C   1 
ATOM   46   O  O   . PHE A 1 7   ? 10.063  10.108  19.076  1.00 31.17 ? 7   PHE A O   1 
ATOM   47   C  CB  . PHE A 1 7   ? 9.900   7.250   21.006  1.00 30.91 ? 7   PHE A CB  1 
ATOM   48   C  CG  . PHE A 1 7   ? 10.518  8.231   21.940  1.00 40.90 ? 7   PHE A CG  1 
ATOM   49   C  CD1 . PHE A 1 7   ? 9.723   9.144   22.640  1.00 46.51 ? 7   PHE A CD1 1 
ATOM   50   C  CD2 . PHE A 1 7   ? 11.909  8.314   22.060  1.00 43.65 ? 7   PHE A CD2 1 
ATOM   51   C  CE1 . PHE A 1 7   ? 10.313  10.091  23.467  1.00 50.49 ? 7   PHE A CE1 1 
ATOM   52   C  CE2 . PHE A 1 7   ? 12.491  9.263   22.882  1.00 45.02 ? 7   PHE A CE2 1 
ATOM   53   C  CZ  . PHE A 1 7   ? 11.695  10.152  23.574  1.00 43.24 ? 7   PHE A CZ  1 
ATOM   54   N  N   . GLY A 1 8   ? 8.145   9.316   19.956  1.00 27.67 ? 8   GLY A N   1 
ATOM   55   C  CA  . GLY A 1 8   ? 7.489   10.621  20.232  1.00 25.32 ? 8   GLY A CA  1 
ATOM   56   C  C   . GLY A 1 8   ? 7.611   11.536  19.043  1.00 31.57 ? 8   GLY A C   1 
ATOM   57   O  O   . GLY A 1 8   ? 7.791   11.077  17.916  1.00 29.62 ? 8   GLY A O   1 
ATOM   58   N  N   . PRO A 1 9   ? 7.591   12.840  19.304  1.00 25.54 ? 9   PRO A N   1 
ATOM   59   C  CA  . PRO A 1 9   ? 7.482   13.879  18.298  1.00 25.50 ? 9   PRO A CA  1 
ATOM   60   C  C   . PRO A 1 9   ? 8.673   13.956  17.391  1.00 23.09 ? 9   PRO A C   1 
ATOM   61   O  O   . PRO A 1 9   ? 8.584   14.496  16.283  1.00 21.14 ? 9   PRO A O   1 
ATOM   62   C  CB  . PRO A 1 9   ? 7.507   15.200  19.139  1.00 27.38 ? 9   PRO A CB  1 
ATOM   63   C  CG  . PRO A 1 9   ? 7.204   14.783  20.516  1.00 29.94 ? 9   PRO A CG  1 
ATOM   64   C  CD  . PRO A 1 9   ? 7.681   13.387  20.683  1.00 28.21 ? 9   PRO A CD  1 
ATOM   65   N  N   . ASP A 1 10  ? 9.839   13.516  17.872  1.00 20.08 ? 10  ASP A N   1 
ATOM   66   C  CA  . ASP A 1 10  ? 11.059  13.629  17.093  1.00 19.03 ? 10  ASP A CA  1 
ATOM   67   C  C   . ASP A 1 10  ? 11.498  12.283  16.477  1.00 16.12 ? 10  ASP A C   1 
ATOM   68   O  O   . ASP A 1 10  ? 12.664  12.186  16.026  1.00 15.73 ? 10  ASP A O   1 
ATOM   69   C  CB  . ASP A 1 10  ? 12.197  14.152  18.025  1.00 22.45 ? 10  ASP A CB  1 
ATOM   70   C  CG  . ASP A 1 10  ? 11.930  15.582  18.501  1.00 30.99 ? 10  ASP A CG  1 
ATOM   71   O  OD1 . ASP A 1 10  ? 11.560  16.448  17.641  1.00 29.67 ? 10  ASP A OD1 1 
ATOM   72   O  OD2 . ASP A 1 10  ? 12.105  15.803  19.735  1.00 35.32 ? 10  ASP A OD2 1 
ATOM   73   N  N   . GLY A 1 11  ? 10.550  11.329  16.478  1.00 14.58 ? 11  GLY A N   1 
ATOM   74   C  CA  . GLY A 1 11  ? 10.706  9.969   15.903  1.00 11.50 ? 11  GLY A CA  1 
ATOM   75   C  C   . GLY A 1 11  ? 10.845  9.949   14.363  1.00 10.42 ? 11  GLY A C   1 
ATOM   76   O  O   . GLY A 1 11  ? 10.941  10.947  13.649  1.00 9.66  ? 11  GLY A O   1 
ATOM   77   N  N   . GLU A 1 12  ? 10.905  8.740   13.804  1.00 8.26  ? 12  GLU A N   1 
ATOM   78   C  CA  . GLU A 1 12  ? 11.385  8.549   12.444  1.00 7.48  ? 12  GLU A CA  1 
ATOM   79   C  C   . GLU A 1 12  ? 10.474  9.183   11.368  1.00 7.03  ? 12  GLU A C   1 
ATOM   80   O  O   . GLU A 1 12  ? 11.015  9.542   10.364  1.00 6.59  ? 12  GLU A O   1 
ATOM   81   C  CB  . GLU A 1 12  ? 11.569  7.040   12.145  1.00 8.15  ? 12  GLU A CB  1 
ATOM   82   C  CG  . GLU A 1 12  ? 10.239  6.258   12.148  1.00 8.87  ? 12  GLU A CG  1 
ATOM   83   C  CD  . GLU A 1 12  ? 10.572  4.746   12.232  1.00 8.35  ? 12  GLU A CD  1 
ATOM   84   O  OE1 . GLU A 1 12  ? 10.810  4.129   11.227  1.00 7.68  ? 12  GLU A OE1 1 
ATOM   85   O  OE2 . GLU A 1 12  ? 10.589  4.285   13.401  1.00 11.00 ? 12  GLU A OE2 1 
ATOM   86   N  N   . ASN A 1 13  ? 9.162   9.400   11.659  1.00 7.76  ? 13  ASN A N   1 
ATOM   87   C  CA  . ASN A 1 13  ? 8.338   10.019  10.617  1.00 7.68  ? 13  ASN A CA  1 
ATOM   88   C  C   . ASN A 1 13  ? 8.696   11.498  10.493  1.00 8.27  ? 13  ASN A C   1 
ATOM   89   O  O   . ASN A 1 13  ? 8.285   12.089  9.497   1.00 9.23  ? 13  ASN A O   1 
ATOM   90   C  CB  . ASN A 1 13  ? 6.905   9.905   10.983  1.00 7.32  ? 13  ASN A CB  1 
ATOM   91   C  CG  . ASN A 1 13  ? 6.392   8.466   10.804  1.00 7.39  ? 13  ASN A CG  1 
ATOM   92   O  OD1 . ASN A 1 13  ? 7.075   7.606   10.301  1.00 8.65  ? 13  ASN A OD1 1 
ATOM   93   N  ND2 . ASN A 1 13  ? 5.211   8.285   11.245  1.00 6.99  ? 13  ASN A ND2 1 
ATOM   94   N  N   A SER A 1 14  ? 9.410   12.056  11.455  0.50 8.14  ? 14  SER A N   1 
ATOM   95   N  N   B SER A 1 14  ? 9.356   12.086  11.490  0.50 8.39  ? 14  SER A N   1 
ATOM   96   C  CA  A SER A 1 14  ? 9.765   13.490  11.417  0.50 7.81  ? 14  SER A CA  1 
ATOM   97   C  CA  B SER A 1 14  ? 9.761   13.529  11.440  0.50 8.22  ? 14  SER A CA  1 
ATOM   98   C  C   A SER A 1 14  ? 11.219  13.732  11.125  0.50 7.98  ? 14  SER A C   1 
ATOM   99   C  C   B SER A 1 14  ? 11.213  13.735  10.962  0.50 8.50  ? 14  SER A C   1 
ATOM   100  O  O   A SER A 1 14  ? 11.613  14.915  11.090  0.50 7.64  ? 14  SER A O   1 
ATOM   101  O  O   B SER A 1 14  ? 11.631  14.866  10.647  0.50 8.32  ? 14  SER A O   1 
ATOM   102  C  CB  A SER A 1 14  ? 9.551   14.091  12.767  0.50 9.31  ? 14  SER A CB  1 
ATOM   103  C  CB  B SER A 1 14  ? 9.662   14.150  12.825  0.50 9.99  ? 14  SER A CB  1 
ATOM   104  O  OG  A SER A 1 14  ? 8.178   14.075  13.031  0.50 10.42 ? 14  SER A OG  1 
ATOM   105  O  OG  B SER A 1 14  ? 10.677  13.669  13.693  0.50 12.40 ? 14  SER A OG  1 
ATOM   106  N  N   . TRP A 1 15  ? 12.017  12.701  10.884  1.00 7.39  ? 15  TRP A N   1 
ATOM   107  C  CA  . TRP A 1 15  ? 13.420  12.889  10.489  1.00 7.66  ? 15  TRP A CA  1 
ATOM   108  C  C   . TRP A 1 15  ? 13.596  13.692  9.250   1.00 8.33  ? 15  TRP A C   1 
ATOM   109  O  O   . TRP A 1 15  ? 14.583  14.497  9.159   1.00 8.40  ? 15  TRP A O   1 
ATOM   110  C  CB  . TRP A 1 15  ? 14.139  11.533  10.264  1.00 7.03  ? 15  TRP A CB  1 
ATOM   111  C  CG  . TRP A 1 15  ? 14.285  10.736  11.538  1.00 6.86  ? 15  TRP A CG  1 
ATOM   112  C  CD1 . TRP A 1 15  ? 13.993  11.074  12.800  1.00 7.52  ? 15  TRP A CD1 1 
ATOM   113  C  CD2 . TRP A 1 15  ? 14.731  9.373   11.535  1.00 6.55  ? 15  TRP A CD2 1 
ATOM   114  N  NE1 . TRP A 1 15  ? 14.298  10.017  13.700  1.00 7.35  ? 15  TRP A NE1 1 
ATOM   115  C  CE2 . TRP A 1 15  ? 14.769  8.979   12.934  1.00 6.19  ? 15  TRP A CE2 1 
ATOM   116  C  CE3 . TRP A 1 15  ? 15.189  8.512   10.570  1.00 6.68  ? 15  TRP A CE3 1 
ATOM   117  C  CZ2 . TRP A 1 15  ? 15.191  7.632   13.290  1.00 6.62  ? 15  TRP A CZ2 1 
ATOM   118  C  CZ3 . TRP A 1 15  ? 15.623  7.213   10.955  1.00 6.95  ? 15  TRP A CZ3 1 
ATOM   119  C  CH2 . TRP A 1 15  ? 15.634  6.860   12.291  1.00 6.79  ? 15  TRP A CH2 1 
ATOM   120  N  N   . SER A 1 16  ? 12.707  13.591  8.277   1.00 7.50  ? 16  SER A N   1 
ATOM   121  C  CA  . SER A 1 16  ? 12.910  14.204  6.977   1.00 8.21  ? 16  SER A CA  1 
ATOM   122  C  C   . SER A 1 16  ? 12.772  15.745  7.101   1.00 7.75  ? 16  SER A C   1 
ATOM   123  O  O   . SER A 1 16  ? 13.219  16.352  6.097   1.00 7.24  ? 16  SER A O   1 
ATOM   124  C  CB  . SER A 1 16  ? 11.858  13.706  5.985   1.00 8.48  ? 16  SER A CB  1 
ATOM   125  O  OG  . SER A 1 16  ? 10.585  14.085  6.467   1.00 9.59  ? 16  SER A OG  1 
ATOM   126  N  N   A LYS A 1 17  ? 12.228  16.280  8.189   0.50 8.15  ? 17  LYS A N   1 
ATOM   127  N  N   B LYS A 1 17  ? 12.278  16.272  8.199   0.50 7.98  ? 17  LYS A N   1 
ATOM   128  C  CA  A LYS A 1 17  ? 12.232  17.774  8.347   0.50 8.45  ? 17  LYS A CA  1 
ATOM   129  C  CA  B LYS A 1 17  ? 12.227  17.746  8.237   0.50 8.22  ? 17  LYS A CA  1 
ATOM   130  C  C   A LYS A 1 17  ? 13.680  18.265  8.249   0.50 8.35  ? 17  LYS A C   1 
ATOM   131  C  C   B LYS A 1 17  ? 13.575  18.375  8.405   0.50 8.17  ? 17  LYS A C   1 
ATOM   132  O  O   A LYS A 1 17  ? 14.098  19.033  7.312   0.50 7.26  ? 17  LYS A O   1 
ATOM   133  O  O   B LYS A 1 17  ? 13.789  19.405  7.827   0.50 7.30  ? 17  LYS A O   1 
ATOM   134  C  CB  A LYS A 1 17  ? 11.561  18.160  9.668   0.50 9.67  ? 17  LYS A CB  1 
ATOM   135  C  CB  B LYS A 1 17  ? 11.294  18.223  9.290   0.50 8.94  ? 17  LYS A CB  1 
ATOM   136  C  CG  A LYS A 1 17  ? 10.052  17.896  9.618   0.50 11.28 ? 17  LYS A CG  1 
ATOM   137  C  CG  B LYS A 1 17  ? 11.311  19.745  9.410   0.50 10.05 ? 17  LYS A CG  1 
ATOM   138  C  CD  A LYS A 1 17  ? 9.531   17.537  10.999  0.50 14.44 ? 17  LYS A CD  1 
ATOM   139  C  CD  B LYS A 1 17  ? 10.559  20.297  10.622  0.50 11.73 ? 17  LYS A CD  1 
ATOM   140  C  CE  A LYS A 1 17  ? 8.083   17.059  10.989  0.50 15.37 ? 17  LYS A CE  1 
ATOM   141  C  CE  B LYS A 1 17  ? 9.062   20.008  10.483  0.50 11.80 ? 17  LYS A CE  1 
ATOM   142  N  NZ  A LYS A 1 17  ? 7.460   17.385  12.314  0.50 20.91 ? 17  LYS A NZ  1 
ATOM   143  N  NZ  B LYS A 1 17  ? 8.148   20.455  11.556  0.50 13.96 ? 17  LYS A NZ  1 
ATOM   144  N  N   . LYS A 1 18  ? 14.467  17.799  9.214   1.00 8.67  ? 18  LYS A N   1 
ATOM   145  C  CA  . LYS A 1 18  ? 15.818  18.275  9.297   1.00 9.54  ? 18  LYS A CA  1 
ATOM   146  C  C   . LYS A 1 18  ? 16.780  17.530  8.406   1.00 10.16 ? 18  LYS A C   1 
ATOM   147  O  O   . LYS A 1 18  ? 17.893  18.052  8.055   1.00 13.15 ? 18  LYS A O   1 
ATOM   148  C  CB  . LYS A 1 18  ? 16.315  18.150  10.741  1.00 12.26 ? 18  LYS A CB  1 
ATOM   149  C  CG  . LYS A 1 18  ? 17.785  18.607  10.849  1.00 17.20 ? 18  LYS A CG  1 
ATOM   150  C  CD  . LYS A 1 18  ? 18.201  18.474  12.334  1.00 22.23 ? 18  LYS A CD  1 
ATOM   151  C  CE  . LYS A 1 18  ? 19.656  18.821  12.611  1.00 24.79 ? 18  LYS A CE  1 
ATOM   152  N  NZ  . LYS A 1 18  ? 19.664  19.368  14.023  1.00 35.20 ? 18  LYS A NZ  1 
ATOM   153  N  N   . TYR A 1 19  ? 16.432  16.295  7.976   1.00 8.68  ? 19  TYR A N   1 
ATOM   154  C  CA  . TYR A 1 19  ? 17.349  15.490  7.240   1.00 8.30  ? 19  TYR A CA  1 
ATOM   155  C  C   . TYR A 1 19  ? 16.673  15.018  5.996   1.00 8.73  ? 19  TYR A C   1 
ATOM   156  O  O   . TYR A 1 19  ? 16.041  13.933  5.934   1.00 8.50  ? 19  TYR A O   1 
ATOM   157  C  CB  . TYR A 1 19  ? 17.751  14.260  8.105   1.00 8.94  ? 19  TYR A CB  1 
ATOM   158  C  CG  . TYR A 1 19  ? 18.406  14.639  9.453   1.00 9.67  ? 19  TYR A CG  1 
ATOM   159  C  CD1 . TYR A 1 19  ? 19.789  14.963  9.490   1.00 9.74  ? 19  TYR A CD1 1 
ATOM   160  C  CD2 . TYR A 1 19  ? 17.685  14.626  10.605  1.00 9.63  ? 19  TYR A CD2 1 
ATOM   161  C  CE1 . TYR A 1 19  ? 20.366  15.297  10.694  1.00 10.63 ? 19  TYR A CE1 1 
ATOM   162  C  CE2 . TYR A 1 19  ? 18.262  14.963  11.820  1.00 10.45 ? 19  TYR A CE2 1 
ATOM   163  C  CZ  . TYR A 1 19  ? 19.603  15.274  11.831  1.00 12.58 ? 19  TYR A CZ  1 
ATOM   164  O  OH  . TYR A 1 19  ? 20.223  15.593  13.104  1.00 17.23 ? 19  TYR A OH  1 
ATOM   165  N  N   . PRO A 1 20  ? 16.713  15.797  4.937   1.00 8.02  ? 20  PRO A N   1 
ATOM   166  C  CA  . PRO A 1 20  ? 15.846  15.577  3.859   1.00 8.53  ? 20  PRO A CA  1 
ATOM   167  C  C   . PRO A 1 20  ? 16.070  14.217  3.209   1.00 7.91  ? 20  PRO A C   1 
ATOM   168  O  O   . PRO A 1 20  ? 15.155  13.673  2.535   1.00 9.18  ? 20  PRO A O   1 
ATOM   169  C  CB  . PRO A 1 20  ? 16.188  16.687  2.866   1.00 9.90  ? 20  PRO A CB  1 
ATOM   170  C  CG  . PRO A 1 20  ? 16.724  17.768  3.751   1.00 13.21 ? 20  PRO A CG  1 
ATOM   171  C  CD  . PRO A 1 20  ? 17.484  17.074  4.845   1.00 10.46 ? 20  PRO A CD  1 
ATOM   172  N  N   . SER A 1 21  ? 17.310  13.619  3.251   1.00 7.38  ? 21  SER A N   1 
ATOM   173  C  CA  . SER A 1 21  ? 17.485  12.313  2.625   1.00 8.12  ? 21  SER A CA  1 
ATOM   174  C  C   . SER A 1 21  ? 16.591  11.237  3.275   1.00 8.04  ? 21  SER A C   1 
ATOM   175  O  O   . SER A 1 21  ? 16.375  10.222  2.590   1.00 6.75  ? 21  SER A O   1 
ATOM   176  C  CB  . SER A 1 21  ? 18.987  11.898  2.644   1.00 9.54  ? 21  SER A CB  1 
ATOM   177  O  OG  . SER A 1 21  ? 19.765  12.747  1.725   1.00 11.70 ? 21  SER A OG  1 
ATOM   178  N  N   . CYS A 1 22  ? 16.104  11.459  4.483   1.00 7.29  ? 22  CYS A N   1 
ATOM   179  C  CA  . CYS A 1 22  ? 15.280  10.430  5.111   1.00 7.82  ? 22  CYS A CA  1 
ATOM   180  C  C   . CYS A 1 22  ? 13.972  10.258  4.389   1.00 8.94  ? 22  CYS A C   1 
ATOM   181  O  O   . CYS A 1 22  ? 13.264  9.296   4.655   1.00 9.37  ? 22  CYS A O   1 
ATOM   182  C  CB  . CYS A 1 22  ? 15.039  10.776  6.569   1.00 6.70  ? 22  CYS A CB  1 
ATOM   183  S  SG  . CYS A 1 22  ? 16.632  10.842  7.523   1.00 9.64  ? 22  CYS A SG  1 
ATOM   184  N  N   . GLY A 1 23  ? 13.624  11.253  3.587   1.00 9.20  ? 23  GLY A N   1 
ATOM   185  C  CA  . GLY A 1 23  ? 12.454  11.164  2.717   1.00 9.13  ? 23  GLY A CA  1 
ATOM   186  C  C   . GLY A 1 23  ? 12.739  10.967  1.282   1.00 8.45  ? 23  GLY A C   1 
ATOM   187  O  O   . GLY A 1 23  ? 11.850  11.017  0.422   1.00 8.64  ? 23  GLY A O   1 
ATOM   188  N  N   . GLY A 1 24  ? 13.975  10.683  0.941   1.00 8.35  ? 24  GLY A N   1 
ATOM   189  C  CA  . GLY A 1 24  ? 14.409  10.418  -0.422  1.00 8.69  ? 24  GLY A CA  1 
ATOM   190  C  C   . GLY A 1 24  ? 14.507  8.999   -0.859  1.00 9.17  ? 24  GLY A C   1 
ATOM   191  O  O   . GLY A 1 24  ? 13.782  8.164   -0.266  1.00 9.77  ? 24  GLY A O   1 
ATOM   192  N  N   . LEU A 1 25  ? 15.268  8.764   -1.909  1.00 9.99  ? 25  LEU A N   1 
ATOM   193  C  CA  . LEU A 1 25  ? 15.406  7.480   -2.477  1.00 11.15 ? 25  LEU A CA  1 
ATOM   194  C  C   . LEU A 1 25  ? 16.307  6.556   -1.683  1.00 10.23 ? 25  LEU A C   1 
ATOM   195  O  O   . LEU A 1 25  ? 17.120  6.978   -0.886  1.00 9.53  ? 25  LEU A O   1 
ATOM   196  C  CB  . LEU A 1 25  ? 16.006  7.623   -3.876  1.00 14.89 ? 25  LEU A CB  1 
ATOM   197  C  CG  . LEU A 1 25  ? 15.114  8.456   -4.831  1.00 17.11 ? 25  LEU A CG  1 
ATOM   198  C  CD1 . LEU A 1 25  ? 15.777  8.538   -6.193  1.00 23.39 ? 25  LEU A CD1 1 
ATOM   199  C  CD2 . LEU A 1 25  ? 13.651  8.010   -5.017  1.00 21.11 ? 25  LEU A CD2 1 
ATOM   200  N  N   . LEU A 1 26  ? 16.172  5.278   -2.008  1.00 11.16 ? 26  LEU A N   1 
ATOM   201  C  CA  . LEU A 1 26  ? 17.103  4.210   -1.659  1.00 11.47 ? 26  LEU A CA  1 
ATOM   202  C  C   . LEU A 1 26  ? 17.119  4.001   -0.119  1.00 10.03 ? 26  LEU A C   1 
ATOM   203  O  O   . LEU A 1 26  ? 18.143  3.627   0.460   1.00 10.45 ? 26  LEU A O   1 
ATOM   204  C  CB  . LEU A 1 26  ? 18.538  4.399   -2.245  1.00 13.24 ? 26  LEU A CB  1 
ATOM   205  C  CG  . LEU A 1 26  ? 18.716  4.419   -3.795  1.00 19.23 ? 26  LEU A CG  1 
ATOM   206  C  CD1 . LEU A 1 26  ? 20.214  4.533   -4.141  1.00 21.60 ? 26  LEU A CD1 1 
ATOM   207  C  CD2 . LEU A 1 26  ? 18.200  3.157   -4.432  1.00 19.58 ? 26  LEU A CD2 1 
ATOM   208  N  N   . GLN A 1 27  ? 16.025  4.197   0.556   1.00 7.79  ? 27  GLN A N   1 
ATOM   209  C  CA  . GLN A 1 27  ? 16.045  4.120   2.040   1.00 6.95  ? 27  GLN A CA  1 
ATOM   210  C  C   . GLN A 1 27  ? 16.039  2.685   2.527   1.00 7.19  ? 27  GLN A C   1 
ATOM   211  O  O   . GLN A 1 27  ? 15.381  1.783   1.995   1.00 8.44  ? 27  GLN A O   1 
ATOM   212  C  CB  . GLN A 1 27  ? 14.865  4.852   2.644   1.00 6.33  ? 27  GLN A CB  1 
ATOM   213  C  CG  . GLN A 1 27  ? 14.941  6.359   2.351   1.00 6.07  ? 27  GLN A CG  1 
ATOM   214  C  CD  . GLN A 1 27  ? 16.125  6.996   3.032   1.00 5.74  ? 27  GLN A CD  1 
ATOM   215  O  OE1 . GLN A 1 27  ? 16.089  7.183   4.220   1.00 6.28  ? 27  GLN A OE1 1 
ATOM   216  N  NE2 . GLN A 1 27  ? 17.179  7.292   2.283   1.00 6.41  ? 27  GLN A NE2 1 
ATOM   217  N  N   . SER A 1 28  ? 16.809  2.501   3.586   1.00 6.10  ? 28  SER A N   1 
ATOM   218  C  CA  . SER A 1 28  ? 16.910  1.243   4.336   1.00 5.91  ? 28  SER A CA  1 
ATOM   219  C  C   . SER A 1 28  ? 16.302  1.451   5.718   1.00 6.06  ? 28  SER A C   1 
ATOM   220  O  O   . SER A 1 28  ? 16.206  2.556   6.223   1.00 6.02  ? 28  SER A O   1 
ATOM   221  C  CB  . SER A 1 28  ? 18.425  0.967   4.495   1.00 6.40  ? 28  SER A CB  1 
ATOM   222  O  OG  . SER A 1 28  ? 18.966  0.656   3.229   1.00 6.38  ? 28  SER A OG  1 
ATOM   223  N  N   . PRO A 1 29  ? 15.960  0.376   6.461   1.00 5.86  ? 29  PRO A N   1 
ATOM   224  C  CA  . PRO A 1 29  ? 16.102  -1.009  6.082   1.00 5.41  ? 29  PRO A CA  1 
ATOM   225  C  C   . PRO A 1 29  ? 14.893  -1.484  5.312   1.00 5.14  ? 29  PRO A C   1 
ATOM   226  O  O   . PRO A 1 29  ? 13.955  -0.715  5.070   1.00 6.30  ? 29  PRO A O   1 
ATOM   227  C  CB  . PRO A 1 29  ? 16.156  -1.716  7.469   1.00 5.80  ? 29  PRO A CB  1 
ATOM   228  C  CG  . PRO A 1 29  ? 15.105  -0.905  8.240   1.00 5.94  ? 29  PRO A CG  1 
ATOM   229  C  CD  . PRO A 1 29  ? 15.456  0.556   7.823   1.00 5.35  ? 29  PRO A CD  1 
ATOM   230  N  N   . ILE A 1 30  ? 14.909  -2.742  4.862   1.00 6.19  ? 30  ILE A N   1 
ATOM   231  C  CA  . ILE A 1 30  ? 13.864  -3.280  3.994   1.00 6.79  ? 30  ILE A CA  1 
ATOM   232  C  C   . ILE A 1 30  ? 13.586  -4.695  4.436   1.00 7.05  ? 30  ILE A C   1 
ATOM   233  O  O   . ILE A 1 30  ? 14.351  -5.333  5.224   1.00 7.42  ? 30  ILE A O   1 
ATOM   234  C  CB  . ILE A 1 30  ? 14.350  -3.304  2.523   1.00 7.52  ? 30  ILE A CB  1 
ATOM   235  C  CG1 . ILE A 1 30  ? 15.622  -4.182  2.360   1.00 6.95  ? 30  ILE A CG1 1 
ATOM   236  C  CG2 . ILE A 1 30  ? 14.591  -1.850  2.118   1.00 8.29  ? 30  ILE A CG2 1 
ATOM   237  C  CD1 . ILE A 1 30  ? 15.947  -4.320  0.860   1.00 9.14  ? 30  ILE A CD1 1 
ATOM   238  N  N   . ASP A 1 31  ? 12.416  -5.200  4.038   1.00 7.52  ? 31  ASP A N   1 
ATOM   239  C  CA  . ASP A 1 31  ? 12.093  -6.583  4.184   1.00 7.91  ? 31  ASP A CA  1 
ATOM   240  C  C   . ASP A 1 31  ? 12.708  -7.407  3.064   1.00 9.20  ? 31  ASP A C   1 
ATOM   241  O  O   . ASP A 1 31  ? 12.605  -7.142  1.845   1.00 11.01 ? 31  ASP A O   1 
ATOM   242  C  CB  . ASP A 1 31  ? 10.582  -6.740  4.098   1.00 8.86  ? 31  ASP A CB  1 
ATOM   243  C  CG  . ASP A 1 31  ? 10.138  -8.184  4.351   1.00 12.75 ? 31  ASP A CG  1 
ATOM   244  O  OD1 . ASP A 1 31  ? 10.676  -8.923  5.244   1.00 10.30 ? 31  ASP A OD1 1 
ATOM   245  O  OD2 . ASP A 1 31  ? 9.147   -8.565  3.700   1.00 15.52 ? 31  ASP A OD2 1 
ATOM   246  N  N   . LEU A 1 32  ? 13.423  -8.431  3.437   1.00 8.61  ? 32  LEU A N   1 
ATOM   247  C  CA  . LEU A 1 32  ? 14.079  -9.378  2.510   1.00 10.66 ? 32  LEU A CA  1 
ATOM   248  C  C   . LEU A 1 32  ? 13.162  -10.563 2.318   1.00 11.97 ? 32  LEU A C   1 
ATOM   249  O  O   . LEU A 1 32  ? 12.939  -11.340 3.214   1.00 14.19 ? 32  LEU A O   1 
ATOM   250  C  CB  . LEU A 1 32  ? 15.420  -9.843  3.092   1.00 10.78 ? 32  LEU A CB  1 
ATOM   251  C  CG  . LEU A 1 32  ? 16.326  -8.672  3.504   1.00 9.48  ? 32  LEU A CG  1 
ATOM   252  C  CD1 . LEU A 1 32  ? 17.572  -9.122  4.272   1.00 11.72 ? 32  LEU A CD1 1 
ATOM   253  C  CD2 . LEU A 1 32  ? 16.754  -7.953  2.229   1.00 11.15 ? 32  LEU A CD2 1 
ATOM   254  N  N   . HIS A 1 33  ? 12.625  -10.747 1.137   1.00 16.25 ? 33  HIS A N   1 
ATOM   255  C  CA  . HIS A 1 33  ? 11.609  -11.798 0.993   1.00 18.32 ? 33  HIS A CA  1 
ATOM   256  C  C   . HIS A 1 33  ? 11.757  -12.358 -0.374  1.00 18.66 ? 33  HIS A C   1 
ATOM   257  O  O   . HIS A 1 33  ? 12.264  -11.657 -1.200  1.00 17.90 ? 33  HIS A O   1 
ATOM   258  C  CB  . HIS A 1 33  ? 10.188  -11.307 1.288   1.00 18.51 ? 33  HIS A CB  1 
ATOM   259  C  CG  . HIS A 1 33  ? 9.696   -10.241 0.338   1.00 22.81 ? 33  HIS A CG  1 
ATOM   260  N  ND1 . HIS A 1 33  ? 9.967   -8.962  0.508   1.00 22.33 ? 33  HIS A ND1 1 
ATOM   261  C  CD2 . HIS A 1 33  ? 8.924   -10.340 -0.842  1.00 25.05 ? 33  HIS A CD2 1 
ATOM   262  C  CE1 . HIS A 1 33  ? 9.394   -8.233  -0.525  1.00 26.01 ? 33  HIS A CE1 1 
ATOM   263  N  NE2 . HIS A 1 33  ? 8.775   -9.091  -1.338  1.00 29.89 ? 33  HIS A NE2 1 
ATOM   264  N  N   . SER A 1 34  ? 11.268  -13.574 -0.643  1.00 22.83 ? 34  SER A N   1 
ATOM   265  C  CA  . SER A 1 34  ? 11.836  -14.369 -1.768  1.00 27.93 ? 34  SER A CA  1 
ATOM   266  C  C   . SER A 1 34  ? 11.537  -13.839 -3.149  1.00 30.32 ? 34  SER A C   1 
ATOM   267  O  O   . SER A 1 34  ? 12.363  -14.028 -4.048  1.00 28.95 ? 34  SER A O   1 
ATOM   268  C  CB  . SER A 1 34  ? 11.616  -15.884 -1.636  1.00 34.51 ? 34  SER A CB  1 
ATOM   269  O  OG  . SER A 1 34  ? 10.280  -16.150 -1.305  1.00 34.33 ? 34  SER A OG  1 
ATOM   270  N  N   . ASP A 1 35  ? 10.444  -13.085 -3.254  1.00 29.90 ? 35  ASP A N   1 
ATOM   271  C  CA  . ASP A 1 35  ? 9.979   -12.543 -4.524  1.00 30.43 ? 35  ASP A CA  1 
ATOM   272  C  C   . ASP A 1 35  ? 10.896  -11.513 -5.102  1.00 27.10 ? 35  ASP A C   1 
ATOM   273  O  O   . ASP A 1 35  ? 10.868  -11.253 -6.316  1.00 27.96 ? 35  ASP A O   1 
ATOM   274  C  CB  . ASP A 1 35  ? 8.577   -11.945 -4.373  1.00 40.51 ? 35  ASP A CB  1 
ATOM   275  C  CG  . ASP A 1 35  ? 7.469   -12.974 -4.660  1.00 49.70 ? 35  ASP A CG  1 
ATOM   276  O  OD1 . ASP A 1 35  ? 7.766   -14.190 -4.892  1.00 53.96 ? 35  ASP A OD1 1 
ATOM   277  O  OD2 . ASP A 1 35  ? 6.287   -12.559 -4.623  1.00 51.13 ? 35  ASP A OD2 1 
ATOM   278  N  N   . ILE A 1 36  ? 11.711  -10.890 -4.246  1.00 22.09 ? 36  ILE A N   1 
ATOM   279  C  CA  . ILE A 1 36  ? 12.584  -9.792  -4.702  1.00 22.88 ? 36  ILE A CA  1 
ATOM   280  C  C   . ILE A 1 36  ? 13.979  -10.275 -4.609  1.00 21.80 ? 36  ILE A C   1 
ATOM   281  O  O   . ILE A 1 36  ? 14.923  -9.541  -4.811  1.00 21.63 ? 36  ILE A O   1 
ATOM   282  C  CB  . ILE A 1 36  ? 12.422  -8.500  -3.897  1.00 21.78 ? 36  ILE A CB  1 
ATOM   283  C  CG1 . ILE A 1 36  ? 12.702  -8.778  -2.384  1.00 21.53 ? 36  ILE A CG1 1 
ATOM   284  C  CG2 . ILE A 1 36  ? 11.087  -7.832  -4.159  1.00 21.98 ? 36  ILE A CG2 1 
ATOM   285  C  CD1 . ILE A 1 36  ? 12.970  -7.521  -1.619  1.00 23.99 ? 36  ILE A CD1 1 
ATOM   286  N  N   . LEU A 1 37  ? 14.146  -11.535 -4.297  1.00 19.98 ? 37  LEU A N   1 
ATOM   287  C  CA  . LEU A 1 37  ? 15.569  -12.045 -4.196  1.00 18.95 ? 37  LEU A CA  1 
ATOM   288  C  C   . LEU A 1 37  ? 16.038  -12.557 -5.616  1.00 20.79 ? 37  LEU A C   1 
ATOM   289  O  O   . LEU A 1 37  ? 15.260  -13.175 -6.379  1.00 24.11 ? 37  LEU A O   1 
ATOM   290  C  CB  . LEU A 1 37  ? 15.684  -13.155 -3.154  1.00 17.84 ? 37  LEU A CB  1 
ATOM   291  C  CG  . LEU A 1 37  ? 15.222  -12.813 -1.736  1.00 18.78 ? 37  LEU A CG  1 
ATOM   292  C  CD1 . LEU A 1 37  ? 15.403  -14.004 -0.810  1.00 20.78 ? 37  LEU A CD1 1 
ATOM   293  C  CD2 . LEU A 1 37  ? 15.964  -11.597 -1.206  1.00 16.12 ? 37  LEU A CD2 1 
ATOM   294  N  N   . GLN A 1 38  ? 17.293  -12.323 -5.961  1.00 19.67 ? 38  GLN A N   1 
ATOM   295  C  CA  . GLN A 1 38  ? 17.779  -12.955 -7.197  1.00 19.19 ? 38  GLN A CA  1 
ATOM   296  C  C   . GLN A 1 38  ? 19.236  -13.353 -7.005  1.00 18.17 ? 38  GLN A C   1 
ATOM   297  O  O   . GLN A 1 38  ? 20.046  -12.517 -6.583  1.00 14.78 ? 38  GLN A O   1 
ATOM   298  C  CB  . GLN A 1 38  ? 17.707  -11.902 -8.318  1.00 21.58 ? 38  GLN A CB  1 
ATOM   299  C  CG  . GLN A 1 38  ? 18.126  -12.431 -9.694  1.00 26.04 ? 38  GLN A CG  1 
ATOM   300  C  CD  . GLN A 1 38  ? 17.871  -11.428 -10.812 1.00 30.95 ? 38  GLN A CD  1 
ATOM   301  O  OE1 . GLN A 1 38  ? 16.699  -11.213 -11.247 1.00 32.10 ? 38  GLN A OE1 1 
ATOM   302  N  NE2 . GLN A 1 38  ? 18.958  -10.804 -11.284 1.00 27.01 ? 38  GLN A NE2 1 
ATOM   303  N  N   . TYR A 1 39  ? 19.595  -14.602 -7.272  1.00 16.17 ? 39  TYR A N   1 
ATOM   304  C  CA  . TYR A 1 39  ? 20.939  -15.066 -7.219  1.00 16.26 ? 39  TYR A CA  1 
ATOM   305  C  C   . TYR A 1 39  ? 21.834  -14.292 -8.189  1.00 18.66 ? 39  TYR A C   1 
ATOM   306  O  O   . TYR A 1 39  ? 21.482  -14.077 -9.354  1.00 17.51 ? 39  TYR A O   1 
ATOM   307  C  CB  . TYR A 1 39  ? 20.936  -16.573 -7.545  1.00 19.97 ? 39  TYR A CB  1 
ATOM   308  C  CG  . TYR A 1 39  ? 22.302  -17.160 -7.613  1.00 21.83 ? 39  TYR A CG  1 
ATOM   309  C  CD1 . TYR A 1 39  ? 23.108  -17.277 -6.470  1.00 18.94 ? 39  TYR A CD1 1 
ATOM   310  C  CD2 . TYR A 1 39  ? 22.788  -17.702 -8.809  1.00 19.84 ? 39  TYR A CD2 1 
ATOM   311  C  CE1 . TYR A 1 39  ? 24.362  -17.805 -6.526  1.00 21.63 ? 39  TYR A CE1 1 
ATOM   312  C  CE2 . TYR A 1 39  ? 24.049  -18.271 -8.878  1.00 24.19 ? 39  TYR A CE2 1 
ATOM   313  C  CZ  . TYR A 1 39  ? 24.838  -18.367 -7.733  1.00 23.23 ? 39  TYR A CZ  1 
ATOM   314  O  OH  . TYR A 1 39  ? 26.094  -18.915 -7.761  1.00 30.98 ? 39  TYR A OH  1 
ATOM   315  N  N   . ASP A 1 40  ? 23.001  -13.901 -7.720  1.00 16.81 ? 40  ASP A N   1 
ATOM   316  C  CA  . ASP A 1 40  ? 23.983  -13.242 -8.547  1.00 18.76 ? 40  ASP A CA  1 
ATOM   317  C  C   . ASP A 1 40  ? 25.281  -13.956 -8.240  1.00 20.79 ? 40  ASP A C   1 
ATOM   318  O  O   . ASP A 1 40  ? 25.871  -13.831 -7.199  1.00 17.62 ? 40  ASP A O   1 
ATOM   319  C  CB  . ASP A 1 40  ? 23.972  -11.729 -8.241  1.00 20.20 ? 40  ASP A CB  1 
ATOM   320  C  CG  . ASP A 1 40  ? 24.978  -10.923 -9.076  1.00 27.05 ? 40  ASP A CG  1 
ATOM   321  O  OD1 . ASP A 1 40  ? 25.920  -11.503 -9.616  1.00 27.56 ? 40  ASP A OD1 1 
ATOM   322  O  OD2 . ASP A 1 40  ? 24.787  -9.677  -9.131  1.00 34.45 ? 40  ASP A OD2 1 
ATOM   323  N  N   . ALA A 1 41  ? 25.728  -14.776 -9.211  1.00 24.51 ? 41  ALA A N   1 
ATOM   324  C  CA  . ALA A 1 41  ? 27.001  -15.483 -9.101  1.00 27.67 ? 41  ALA A CA  1 
ATOM   325  C  C   . ALA A 1 41  ? 28.199  -14.551 -8.991  1.00 23.20 ? 41  ALA A C   1 
ATOM   326  O  O   . ALA A 1 41  ? 29.270  -14.983 -8.619  1.00 29.57 ? 41  ALA A O   1 
ATOM   327  C  CB  . ALA A 1 41  ? 27.165  -16.412 -10.316 1.00 27.45 ? 41  ALA A CB  1 
ATOM   328  N  N   . SER A 1 42  ? 28.065  -13.256 -9.275  1.00 24.16 ? 42  SER A N   1 
ATOM   329  C  CA  . SER A 1 42  ? 29.178  -12.301 -9.034  1.00 22.47 ? 42  SER A CA  1 
ATOM   330  C  C   . SER A 1 42  ? 29.436  -11.995 -7.539  1.00 25.95 ? 42  SER A C   1 
ATOM   331  O  O   . SER A 1 42  ? 30.382  -11.288 -7.154  1.00 24.89 ? 42  SER A O   1 
ATOM   332  C  CB  . SER A 1 42  ? 28.898  -10.979 -9.765  1.00 27.42 ? 42  SER A CB  1 
ATOM   333  O  OG  . SER A 1 42  ? 28.486  -9.902  -8.923  1.00 31.60 ? 42  SER A OG  1 
ATOM   334  N  N   . LEU A 1 43  ? 28.536  -12.451 -6.689  1.00 19.41 ? 43  LEU A N   1 
ATOM   335  C  CA  . LEU A 1 43  ? 28.695  -12.182 -5.266  1.00 17.87 ? 43  LEU A CA  1 
ATOM   336  C  C   . LEU A 1 43  ? 29.574  -13.191 -4.565  1.00 16.70 ? 43  LEU A C   1 
ATOM   337  O  O   . LEU A 1 43  ? 29.103  -14.158 -3.891  1.00 17.66 ? 43  LEU A O   1 
ATOM   338  C  CB  . LEU A 1 43  ? 27.293  -12.088 -4.660  1.00 14.69 ? 43  LEU A CB  1 
ATOM   339  C  CG  . LEU A 1 43  ? 26.475  -10.917 -5.211  1.00 15.42 ? 43  LEU A CG  1 
ATOM   340  C  CD1 . LEU A 1 43  ? 25.125  -10.929 -4.454  1.00 13.63 ? 43  LEU A CD1 1 
ATOM   341  C  CD2 . LEU A 1 43  ? 27.114  -9.548  -5.074  1.00 16.25 ? 43  LEU A CD2 1 
ATOM   342  N  N   . THR A 1 44  ? 30.879  -12.965 -4.668  1.00 16.32 ? 44  THR A N   1 
ATOM   343  C  CA  . THR A 1 44  ? 31.814  -13.857 -4.099  1.00 18.70 ? 44  THR A CA  1 
ATOM   344  C  C   . THR A 1 44  ? 32.057  -13.591 -2.609  1.00 17.58 ? 44  THR A C   1 
ATOM   345  O  O   . THR A 1 44  ? 31.615  -12.538 -2.084  1.00 16.39 ? 44  THR A O   1 
ATOM   346  C  CB  . THR A 1 44  ? 33.143  -13.727 -4.877  1.00 21.44 ? 44  THR A CB  1 
ATOM   347  O  OG1 . THR A 1 44  ? 33.477  -12.348 -4.921  1.00 22.04 ? 44  THR A OG1 1 
ATOM   348  C  CG2 . THR A 1 44  ? 32.903  -14.192 -6.262  1.00 27.43 ? 44  THR A CG2 1 
ATOM   349  N  N   . PRO A 1 45  ? 32.742  -14.501 -1.916  1.00 16.67 ? 45  PRO A N   1 
ATOM   350  C  CA  . PRO A 1 45  ? 32.965  -14.240 -0.480  1.00 16.85 ? 45  PRO A CA  1 
ATOM   351  C  C   . PRO A 1 45  ? 33.803  -13.039 -0.185  1.00 18.67 ? 45  PRO A C   1 
ATOM   352  O  O   . PRO A 1 45  ? 34.818  -12.808 -0.856  1.00 18.81 ? 45  PRO A O   1 
ATOM   353  C  CB  . PRO A 1 45  ? 33.676  -15.511 0.028   1.00 19.83 ? 45  PRO A CB  1 
ATOM   354  C  CG  . PRO A 1 45  ? 33.266  -16.537 -0.993  1.00 18.59 ? 45  PRO A CG  1 
ATOM   355  C  CD  . PRO A 1 45  ? 33.294  -15.834 -2.305  1.00 18.42 ? 45  PRO A CD  1 
ATOM   356  N  N   . LEU A 1 46  ? 33.389  -12.240 0.791   1.00 16.66 ? 46  LEU A N   1 
ATOM   357  C  CA  . LEU A 1 46  ? 34.214  -11.149 1.270   1.00 15.99 ? 46  LEU A CA  1 
ATOM   358  C  C   . LEU A 1 46  ? 35.383  -11.729 2.101   1.00 14.98 ? 46  LEU A C   1 
ATOM   359  O  O   . LEU A 1 46  ? 35.271  -12.791 2.701   1.00 17.56 ? 46  LEU A O   1 
ATOM   360  C  CB  . LEU A 1 46  ? 33.436  -10.206 2.186   1.00 16.01 ? 46  LEU A CB  1 
ATOM   361  C  CG  . LEU A 1 46  ? 32.315  -9.456  1.436   1.00 16.72 ? 46  LEU A CG  1 
ATOM   362  C  CD1 . LEU A 1 46  ? 31.506  -8.619  2.407   1.00 18.42 ? 46  LEU A CD1 1 
ATOM   363  C  CD2 . LEU A 1 46  ? 32.866  -8.648  0.266   1.00 21.49 ? 46  LEU A CD2 1 
ATOM   364  N  N   . GLU A 1 47  ? 36.427  -10.936 2.195   1.00 14.74 ? 47  GLU A N   1 
ATOM   365  C  CA  . GLU A 1 47  ? 37.487  -11.309 3.061   1.00 15.67 ? 47  GLU A CA  1 
ATOM   366  C  C   . GLU A 1 47  ? 37.601  -10.230 4.101   1.00 14.89 ? 47  GLU A C   1 
ATOM   367  O  O   . GLU A 1 47  ? 37.660  -9.032  3.809   1.00 14.29 ? 47  GLU A O   1 
ATOM   368  C  CB  . GLU A 1 47  ? 38.808  -11.492 2.308   1.00 21.49 ? 47  GLU A CB  1 
ATOM   369  C  CG  . GLU A 1 47  ? 38.641  -12.554 1.213   1.00 28.93 ? 47  GLU A CG  1 
ATOM   370  C  CD  . GLU A 1 47  ? 39.820  -12.678 0.243   1.00 41.04 ? 47  GLU A CD  1 
ATOM   371  O  OE1 . GLU A 1 47  ? 39.658  -13.422 -0.774  1.00 47.38 ? 47  GLU A OE1 1 
ATOM   372  O  OE2 . GLU A 1 47  ? 40.894  -12.062 0.492   1.00 43.38 ? 47  GLU A OE2 1 
ATOM   373  N  N   . PHE A 1 48  ? 37.758  -10.634 5.366   1.00 13.99 ? 48  PHE A N   1 
ATOM   374  C  CA  . PHE A 1 48  ? 37.752  -9.683  6.454   1.00 14.76 ? 48  PHE A CA  1 
ATOM   375  C  C   . PHE A 1 48  ? 39.183  -9.584  6.959   1.00 16.94 ? 48  PHE A C   1 
ATOM   376  O  O   . PHE A 1 48  ? 39.744  -10.597 7.414   1.00 19.74 ? 48  PHE A O   1 
ATOM   377  C  CB  . PHE A 1 48  ? 36.802  -10.184 7.550   1.00 14.95 ? 48  PHE A CB  1 
ATOM   378  C  CG  . PHE A 1 48  ? 35.440  -10.535 7.009   1.00 13.01 ? 48  PHE A CG  1 
ATOM   379  C  CD1 . PHE A 1 48  ? 34.571  -9.569  6.598   1.00 14.86 ? 48  PHE A CD1 1 
ATOM   380  C  CD2 . PHE A 1 48  ? 35.092  -11.921 6.805   1.00 14.79 ? 48  PHE A CD2 1 
ATOM   381  C  CE1 . PHE A 1 48  ? 33.349  -9.967  6.023   1.00 14.58 ? 48  PHE A CE1 1 
ATOM   382  C  CE2 . PHE A 1 48  ? 33.889  -12.308 6.217   1.00 13.17 ? 48  PHE A CE2 1 
ATOM   383  C  CZ  . PHE A 1 48  ? 32.999  -11.286 5.798   1.00 12.99 ? 48  PHE A CZ  1 
ATOM   384  N  N   . GLN A 1 49  ? 39.818  -8.457  6.730   1.00 13.53 ? 49  GLN A N   1 
ATOM   385  C  CA  . GLN A 1 49  ? 41.291  -8.323  6.907   1.00 13.55 ? 49  GLN A CA  1 
ATOM   386  C  C   . GLN A 1 49  ? 41.515  -7.353  8.028   1.00 12.40 ? 49  GLN A C   1 
ATOM   387  O  O   . GLN A 1 49  ? 40.808  -6.323  8.183   1.00 10.93 ? 49  GLN A O   1 
ATOM   388  C  CB  . GLN A 1 49  ? 41.887  -7.645  5.655   1.00 16.34 ? 49  GLN A CB  1 
ATOM   389  C  CG  . GLN A 1 49  ? 41.692  -8.602  4.457   1.00 22.58 ? 49  GLN A CG  1 
ATOM   390  C  CD  . GLN A 1 49  ? 42.717  -8.486  3.336   1.00 30.48 ? 49  GLN A CD  1 
ATOM   391  O  OE1 . GLN A 1 49  ? 43.192  -7.370  2.983   1.00 35.39 ? 49  GLN A OE1 1 
ATOM   392  N  NE2 . GLN A 1 49  ? 42.997  -9.635  2.707   1.00 32.26 ? 49  GLN A NE2 1 
ATOM   393  N  N   . GLY A 1 50  ? 42.423  -7.732  8.938   1.00 12.99 ? 50  GLY A N   1 
ATOM   394  C  CA  . GLY A 1 50  ? 42.686  -6.903  10.068  1.00 12.86 ? 50  GLY A CA  1 
ATOM   395  C  C   . GLY A 1 50  ? 41.543  -6.900  11.110  1.00 12.14 ? 50  GLY A C   1 
ATOM   396  O  O   . GLY A 1 50  ? 41.551  -6.015  12.005  1.00 13.13 ? 50  GLY A O   1 
ATOM   397  N  N   . TYR A 1 51  ? 40.661  -7.905  11.003  1.00 12.02 ? 51  TYR A N   1 
ATOM   398  C  CA  . TYR A 1 51  ? 39.592  -7.997  12.032  1.00 11.89 ? 51  TYR A CA  1 
ATOM   399  C  C   . TYR A 1 51  ? 40.095  -8.548  13.390  1.00 13.58 ? 51  TYR A C   1 
ATOM   400  O  O   . TYR A 1 51  ? 39.419  -8.362  14.383  1.00 13.18 ? 51  TYR A O   1 
ATOM   401  C  CB  . TYR A 1 51  ? 38.464  -8.885  11.503  1.00 11.19 ? 51  TYR A CB  1 
ATOM   402  C  CG  . TYR A 1 51  ? 37.414  -8.173  10.673  1.00 11.28 ? 51  TYR A CG  1 
ATOM   403  C  CD1 . TYR A 1 51  ? 36.065  -8.377  10.922  1.00 10.70 ? 51  TYR A CD1 1 
ATOM   404  C  CD2 . TYR A 1 51  ? 37.766  -7.314  9.639   1.00 11.75 ? 51  TYR A CD2 1 
ATOM   405  C  CE1 . TYR A 1 51  ? 35.093  -7.743  10.175  1.00 10.63 ? 51  TYR A CE1 1 
ATOM   406  C  CE2 . TYR A 1 51  ? 36.796  -6.673  8.885   1.00 12.12 ? 51  TYR A CE2 1 
ATOM   407  C  CZ  . TYR A 1 51  ? 35.461  -6.892  9.160   1.00 11.53 ? 51  TYR A CZ  1 
ATOM   408  O  OH  . TYR A 1 51  ? 34.483  -6.265  8.422   1.00 13.27 ? 51  TYR A OH  1 
ATOM   409  N  N   . ASN A 1 52  ? 41.277  -9.188  13.434  1.00 14.39 ? 52  ASN A N   1 
ATOM   410  C  CA  . ASN A 1 52  ? 41.754  -9.748  14.684  1.00 16.26 ? 52  ASN A CA  1 
ATOM   411  C  C   . ASN A 1 52  ? 42.491  -8.639  15.475  1.00 17.61 ? 52  ASN A C   1 
ATOM   412  O  O   . ASN A 1 52  ? 43.710  -8.470  15.353  1.00 19.50 ? 52  ASN A O   1 
ATOM   413  C  CB  . ASN A 1 52  ? 42.657  -10.940 14.357  1.00 16.06 ? 52  ASN A CB  1 
ATOM   414  C  CG  . ASN A 1 52  ? 42.907  -11.814 15.570  1.00 17.57 ? 52  ASN A CG  1 
ATOM   415  O  OD1 . ASN A 1 52  ? 42.304  -11.669 16.630  1.00 17.62 ? 52  ASN A OD1 1 
ATOM   416  N  ND2 . ASN A 1 52  ? 43.834  -12.744 15.388  1.00 24.63 ? 52  ASN A ND2 1 
ATOM   417  N  N   . LEU A 1 53  ? 41.771  -7.799  16.186  1.00 17.84 ? 53  LEU A N   1 
ATOM   418  C  CA  . LEU A 1 53  ? 42.332  -6.595  16.759  1.00 15.62 ? 53  LEU A CA  1 
ATOM   419  C  C   . LEU A 1 53  ? 43.343  -6.880  17.840  1.00 20.31 ? 53  LEU A C   1 
ATOM   420  O  O   . LEU A 1 53  ? 43.129  -7.773  18.624  1.00 17.96 ? 53  LEU A O   1 
ATOM   421  C  CB  . LEU A 1 53  ? 41.212  -5.703  17.351  1.00 16.02 ? 53  LEU A CB  1 
ATOM   422  C  CG  . LEU A 1 53  ? 40.239  -5.323  16.249  1.00 15.26 ? 53  LEU A CG  1 
ATOM   423  C  CD1 . LEU A 1 53  ? 39.177  -4.552  16.991  1.00 13.95 ? 53  LEU A CD1 1 
ATOM   424  C  CD2 . LEU A 1 53  ? 40.926  -4.583  15.087  1.00 17.27 ? 53  LEU A CD2 1 
ATOM   425  N  N   . SER A 1 54  ? 44.436  -6.121  17.788  1.00 20.83 ? 54  SER A N   1 
ATOM   426  C  CA  . SER A 1 54  ? 45.516  -6.329  18.772  1.00 24.73 ? 54  SER A CA  1 
ATOM   427  C  C   . SER A 1 54  ? 44.917  -6.362  20.175  1.00 23.80 ? 54  SER A C   1 
ATOM   428  O  O   . SER A 1 54  ? 44.313  -5.392  20.603  1.00 22.08 ? 54  SER A O   1 
ATOM   429  C  CB  . SER A 1 54  ? 46.512  -5.138  18.689  1.00 19.94 ? 54  SER A CB  1 
ATOM   430  O  OG  . SER A 1 54  ? 47.554  -5.362  19.644  1.00 23.66 ? 54  SER A OG  1 
ATOM   431  N  N   . ALA A 1 55  ? 45.086  -7.451  20.908  1.00 25.69 ? 55  ALA A N   1 
ATOM   432  C  CA  . ALA A 1 55  ? 44.656  -7.422  22.329  1.00 28.04 ? 55  ALA A CA  1 
ATOM   433  C  C   . ALA A 1 55  ? 45.556  -6.503  23.190  1.00 27.30 ? 55  ALA A C   1 
ATOM   434  O  O   . ALA A 1 55  ? 45.287  -6.298  24.327  1.00 28.13 ? 55  ALA A O   1 
ATOM   435  C  CB  . ALA A 1 55  ? 44.558  -8.823  22.936  1.00 31.40 ? 55  ALA A CB  1 
ATOM   436  N  N   . ASN A 1 56  ? 46.586  -5.891  22.600  1.00 27.63 ? 56  ASN A N   1 
ATOM   437  C  CA  . ASN A 1 56  ? 47.375  -4.828  23.293  1.00 30.30 ? 56  ASN A CA  1 
ATOM   438  C  C   . ASN A 1 56  ? 46.931  -3.430  22.922  1.00 31.24 ? 56  ASN A C   1 
ATOM   439  O  O   . ASN A 1 56  ? 47.611  -2.446  23.198  1.00 29.88 ? 56  ASN A O   1 
ATOM   440  C  CB  . ASN A 1 56  ? 48.877  -4.963  22.964  1.00 31.89 ? 56  ASN A CB  1 
ATOM   441  C  CG  . ASN A 1 56  ? 49.469  -6.256  23.483  1.00 40.60 ? 56  ASN A CG  1 
ATOM   442  O  OD1 . ASN A 1 56  ? 49.077  -6.760  24.557  1.00 41.43 ? 56  ASN A OD1 1 
ATOM   443  N  ND2 . ASN A 1 56  ? 50.385  -6.838  22.701  1.00 39.30 ? 56  ASN A ND2 1 
ATOM   444  N  N   . LYS A 1 57  ? 45.803  -3.347  22.235  1.00 27.93 ? 57  LYS A N   1 
ATOM   445  C  CA  . LYS A 1 57  ? 45.247  -2.064  21.894  1.00 24.82 ? 57  LYS A CA  1 
ATOM   446  C  C   . LYS A 1 57  ? 43.873  -2.004  22.569  1.00 23.53 ? 57  LYS A C   1 
ATOM   447  O  O   . LYS A 1 57  ? 43.258  -3.008  22.798  1.00 21.26 ? 57  LYS A O   1 
ATOM   448  C  CB  . LYS A 1 57  ? 45.099  -1.968  20.368  1.00 25.95 ? 57  LYS A CB  1 
ATOM   449  C  CG  . LYS A 1 57  ? 46.226  -1.273  19.659  1.00 34.35 ? 57  LYS A CG  1 
ATOM   450  C  CD  . LYS A 1 57  ? 45.875  -1.048  18.183  1.00 34.68 ? 57  LYS A CD  1 
ATOM   451  C  CE  . LYS A 1 57  ? 45.033  0.190   17.936  1.00 30.32 ? 57  LYS A CE  1 
ATOM   452  N  NZ  . LYS A 1 57  ? 45.133  0.671   16.509  1.00 34.20 ? 57  LYS A NZ  1 
ATOM   453  N  N   . GLN A 1 58  ? 43.443  -0.807  22.911  1.00 21.79 ? 58  GLN A N   1 
ATOM   454  C  CA  . GLN A 1 58  ? 42.065  -0.552  23.375  1.00 21.07 ? 58  GLN A CA  1 
ATOM   455  C  C   . GLN A 1 58  ? 41.275  0.278   22.381  1.00 19.56 ? 58  GLN A C   1 
ATOM   456  O  O   . GLN A 1 58  ? 41.768  1.180   21.734  1.00 22.29 ? 58  GLN A O   1 
ATOM   457  C  CB  . GLN A 1 58  ? 42.097  0.215   24.706  1.00 21.67 ? 58  GLN A CB  1 
ATOM   458  C  CG  . GLN A 1 58  ? 42.575  -0.725  25.760  1.00 22.12 ? 58  GLN A CG  1 
ATOM   459  C  CD  . GLN A 1 58  ? 42.943  -0.054  27.050  1.00 25.20 ? 58  GLN A CD  1 
ATOM   460  O  OE1 . GLN A 1 58  ? 43.603  -0.678  27.888  1.00 27.75 ? 58  GLN A OE1 1 
ATOM   461  N  NE2 . GLN A 1 58  ? 42.648  1.209   27.162  1.00 22.78 ? 58  GLN A NE2 1 
ATOM   462  N  N   . PHE A 1 59  ? 39.967  -0.036  22.331  1.00 17.32 ? 59  PHE A N   1 
ATOM   463  C  CA  . PHE A 1 59  ? 39.040  0.560   21.375  1.00 15.08 ? 59  PHE A CA  1 
ATOM   464  C  C   . PHE A 1 59  ? 37.888  1.131   22.137  1.00 14.90 ? 59  PHE A C   1 
ATOM   465  O  O   . PHE A 1 59  ? 37.426  0.534   23.086  1.00 14.46 ? 59  PHE A O   1 
ATOM   466  C  CB  . PHE A 1 59  ? 38.568  -0.541  20.437  1.00 16.71 ? 59  PHE A CB  1 
ATOM   467  C  CG  . PHE A 1 59  ? 39.725  -1.153  19.694  1.00 16.46 ? 59  PHE A CG  1 
ATOM   468  C  CD1 . PHE A 1 59  ? 40.219  -0.486  18.574  1.00 17.07 ? 59  PHE A CD1 1 
ATOM   469  C  CD2 . PHE A 1 59  ? 40.410  -2.253  20.207  1.00 16.31 ? 59  PHE A CD2 1 
ATOM   470  C  CE1 . PHE A 1 59  ? 41.382  -0.944  17.931  1.00 17.78 ? 59  PHE A CE1 1 
ATOM   471  C  CE2 . PHE A 1 59  ? 41.587  -2.745  19.563  1.00 17.55 ? 59  PHE A CE2 1 
ATOM   472  C  CZ  . PHE A 1 59  ? 42.041  -2.093  18.399  1.00 17.72 ? 59  PHE A CZ  1 
ATOM   473  N  N   . LEU A 1 60  ? 37.563  2.348   21.763  1.00 14.46 ? 60  LEU A N   1 
ATOM   474  C  CA  . LEU A 1 60  ? 36.604  3.159   22.498  1.00 14.29 ? 60  LEU A CA  1 
ATOM   475  C  C   . LEU A 1 60  ? 35.149  2.689   22.237  1.00 15.94 ? 60  LEU A C   1 
ATOM   476  O  O   . LEU A 1 60  ? 34.674  2.703   21.102  1.00 13.60 ? 60  LEU A O   1 
ATOM   477  C  CB  . LEU A 1 60  ? 36.765  4.608   22.151  1.00 16.70 ? 60  LEU A CB  1 
ATOM   478  C  CG  . LEU A 1 60  ? 36.062  5.677   22.991  1.00 19.91 ? 60  LEU A CG  1 
ATOM   479  C  CD1 . LEU A 1 60  ? 36.653  5.685   24.390  1.00 21.34 ? 60  LEU A CD1 1 
ATOM   480  C  CD2 . LEU A 1 60  ? 36.140  7.036   22.322  1.00 24.16 ? 60  LEU A CD2 1 
ATOM   481  N  N   . LEU A 1 61  ? 34.450  2.357   23.279  1.00 13.75 ? 61  LEU A N   1 
ATOM   482  C  CA  . LEU A 1 61  ? 33.015  2.127   23.326  1.00 15.26 ? 61  LEU A CA  1 
ATOM   483  C  C   . LEU A 1 61  ? 32.317  3.397   23.822  1.00 13.80 ? 61  LEU A C   1 
ATOM   484  O  O   . LEU A 1 61  ? 32.694  3.935   24.859  1.00 16.06 ? 61  LEU A O   1 
ATOM   485  C  CB  . LEU A 1 61  ? 32.749  0.954   24.237  1.00 15.64 ? 61  LEU A CB  1 
ATOM   486  C  CG  . LEU A 1 61  ? 31.326  0.423   24.213  1.00 15.38 ? 61  LEU A CG  1 
ATOM   487  C  CD1 . LEU A 1 61  ? 31.073  -0.347  22.913  1.00 15.90 ? 61  LEU A CD1 1 
ATOM   488  C  CD2 . LEU A 1 61  ? 31.042  -0.515  25.380  1.00 16.09 ? 61  LEU A CD2 1 
ATOM   489  N  N   A THR A 1 62  ? 31.308  3.853   23.103  0.50 14.84 ? 62  THR A N   1 
ATOM   490  N  N   B THR A 1 62  ? 31.355  3.957   23.093  0.50 14.68 ? 62  THR A N   1 
ATOM   491  C  CA  A THR A 1 62  ? 30.582  5.027   23.531  0.50 15.90 ? 62  THR A CA  1 
ATOM   492  C  CA  B THR A 1 62  ? 30.658  5.174   23.572  0.50 15.99 ? 62  THR A CA  1 
ATOM   493  C  C   A THR A 1 62  ? 29.072  4.723   23.550  0.50 15.08 ? 62  THR A C   1 
ATOM   494  C  C   B THR A 1 62  ? 29.148  5.090   23.389  0.50 16.53 ? 62  THR A C   1 
ATOM   495  O  O   A THR A 1 62  ? 28.545  3.925   22.771  0.50 12.25 ? 62  THR A O   1 
ATOM   496  O  O   B THR A 1 62  ? 28.695  4.728   22.335  0.50 13.89 ? 62  THR A O   1 
ATOM   497  C  CB  A THR A 1 62  ? 30.842  6.249   22.599  0.50 19.48 ? 62  THR A CB  1 
ATOM   498  C  CB  B THR A 1 62  ? 31.137  6.476   22.882  0.50 18.02 ? 62  THR A CB  1 
ATOM   499  O  OG1 A THR A 1 62  ? 32.241  6.511   22.412  0.50 21.88 ? 62  THR A OG1 1 
ATOM   500  O  OG1 B THR A 1 62  ? 30.837  6.435   21.460  0.50 18.93 ? 62  THR A OG1 1 
ATOM   501  C  CG2 A THR A 1 62  ? 30.186  7.532   23.109  0.50 18.50 ? 62  THR A CG2 1 
ATOM   502  C  CG2 B THR A 1 62  ? 32.619  6.747   23.135  0.50 19.85 ? 62  THR A CG2 1 
ATOM   503  N  N   . ASN A 1 63  ? 28.382  5.455   24.410  1.00 16.24 ? 63  ASN A N   1 
ATOM   504  C  CA  . ASN A 1 63  ? 26.928  5.581   24.291  1.00 17.48 ? 63  ASN A CA  1 
ATOM   505  C  C   . ASN A 1 63  ? 26.715  6.965   23.752  1.00 15.97 ? 63  ASN A C   1 
ATOM   506  O  O   . ASN A 1 63  ? 27.049  8.050   24.332  1.00 16.86 ? 63  ASN A O   1 
ATOM   507  C  CB  . ASN A 1 63  ? 26.330  5.563   25.690  1.00 14.90 ? 63  ASN A CB  1 
ATOM   508  C  CG  . ASN A 1 63  ? 24.845  5.796   25.691  1.00 15.62 ? 63  ASN A CG  1 
ATOM   509  O  OD1 . ASN A 1 63  ? 24.293  6.479   24.774  1.00 16.16 ? 63  ASN A OD1 1 
ATOM   510  N  ND2 . ASN A 1 63  ? 24.204  5.215   26.655  1.00 14.61 ? 63  ASN A ND2 1 
ATOM   511  N  N   . ASN A 1 64  ? 26.128  7.021   22.558  1.00 21.82 ? 64  ASN A N   1 
ATOM   512  C  CA  . ASN A 1 64  ? 25.905  8.341   21.944  1.00 22.69 ? 64  ASN A CA  1 
ATOM   513  C  C   . ASN A 1 64  ? 24.462  8.811   22.021  1.00 24.67 ? 64  ASN A C   1 
ATOM   514  O  O   . ASN A 1 64  ? 24.046  9.725   21.309  1.00 26.24 ? 64  ASN A O   1 
ATOM   515  C  CB  . ASN A 1 64  ? 26.351  8.350   20.445  1.00 27.58 ? 64  ASN A CB  1 
ATOM   516  C  CG  . ASN A 1 64  ? 25.615  7.309   19.578  1.00 30.21 ? 64  ASN A CG  1 
ATOM   517  O  OD1 . ASN A 1 64  ? 24.490  6.840   19.887  1.00 26.15 ? 64  ASN A OD1 1 
ATOM   518  N  ND2 . ASN A 1 64  ? 26.275  6.939   18.449  1.00 28.50 ? 64  ASN A ND2 1 
ATOM   519  N  N   . GLY A 1 65  ? 23.682  8.150   22.838  1.00 20.96 ? 65  GLY A N   1 
ATOM   520  C  CA  . GLY A 1 65  ? 22.277  8.492   23.001  1.00 25.04 ? 65  GLY A CA  1 
ATOM   521  C  C   . GLY A 1 65  ? 21.320  7.902   21.965  1.00 27.19 ? 65  GLY A C   1 
ATOM   522  O  O   . GLY A 1 65  ? 20.120  8.157   22.117  1.00 28.23 ? 65  GLY A O   1 
ATOM   523  N  N   . HIS A 1 66  ? 21.837  7.234   20.893  1.00 20.24 ? 66  HIS A N   1 
ATOM   524  C  CA  . HIS A 1 66  ? 21.119  6.431   19.857  1.00 18.65 ? 66  HIS A CA  1 
ATOM   525  C  C   . HIS A 1 66  ? 21.424  4.963   19.806  1.00 17.47 ? 66  HIS A C   1 
ATOM   526  O  O   . HIS A 1 66  ? 20.508  4.145   19.560  1.00 19.39 ? 66  HIS A O   1 
ATOM   527  C  CB  . HIS A 1 66  ? 21.292  7.059   18.488  1.00 20.22 ? 66  HIS A CB  1 
ATOM   528  C  CG  . HIS A 1 66  ? 21.130  8.569   18.480  1.00 19.24 ? 66  HIS A CG  1 
ATOM   529  N  ND1 . HIS A 1 66  ? 19.884  9.177   18.604  1.00 21.55 ? 66  HIS A ND1 1 
ATOM   530  C  CD2 . HIS A 1 66  ? 22.049  9.606   18.320  1.00 22.82 ? 66  HIS A CD2 1 
ATOM   531  C  CE1 . HIS A 1 66  ? 20.017  10.515  18.553  1.00 18.72 ? 66  HIS A CE1 1 
ATOM   532  N  NE2 . HIS A 1 66  ? 21.352  10.796  18.380  1.00 21.34 ? 66  HIS A NE2 1 
ATOM   533  N  N   A SER A 1 67  ? 22.663  4.562   20.089  0.50 15.92 ? 67  SER A N   1 
ATOM   534  N  N   B SER A 1 67  ? 22.714  4.604   19.942  0.50 17.68 ? 67  SER A N   1 
ATOM   535  C  CA  A SER A 1 67  ? 22.998  3.163   20.201  0.50 16.81 ? 67  SER A CA  1 
ATOM   536  C  CA  B SER A 1 67  ? 23.194  3.229   19.873  0.50 19.93 ? 67  SER A CA  1 
ATOM   537  C  C   A SER A 1 67  ? 24.269  3.122   21.042  0.50 16.36 ? 67  SER A C   1 
ATOM   538  C  C   B SER A 1 67  ? 24.436  3.182   20.771  0.50 18.82 ? 67  SER A C   1 
ATOM   539  O  O   A SER A 1 67  ? 24.658  4.095   21.645  0.50 16.00 ? 67  SER A O   1 
ATOM   540  O  O   B SER A 1 67  ? 24.947  4.212   21.188  0.50 20.04 ? 67  SER A O   1 
ATOM   541  C  CB  A SER A 1 67  ? 23.237  2.611   18.772  0.50 15.45 ? 67  SER A CB  1 
ATOM   542  C  CB  B SER A 1 67  ? 23.556  2.801   18.414  0.50 19.21 ? 67  SER A CB  1 
ATOM   543  O  OG  A SER A 1 67  ? 23.598  1.219   18.740  0.50 15.37 ? 67  SER A OG  1 
ATOM   544  O  OG  B SER A 1 67  ? 22.551  1.998   17.719  0.50 18.66 ? 67  SER A OG  1 
ATOM   545  N  N   . VAL A 1 68  ? 24.903  1.987   21.049  1.00 17.76 ? 68  VAL A N   1 
ATOM   546  C  CA  . VAL A 1 68  ? 26.204  1.923   21.690  1.00 18.12 ? 68  VAL A CA  1 
ATOM   547  C  C   . VAL A 1 68  ? 27.123  1.696   20.484  1.00 15.43 ? 68  VAL A C   1 
ATOM   548  O  O   . VAL A 1 68  ? 26.813  0.799   19.694  1.00 16.12 ? 68  VAL A O   1 
ATOM   549  C  CB  . VAL A 1 68  ? 26.177  0.881   22.803  1.00 20.78 ? 68  VAL A CB  1 
ATOM   550  C  CG1 . VAL A 1 68  ? 25.662  -0.505  22.367  1.00 21.30 ? 68  VAL A CG1 1 
ATOM   551  C  CG2 . VAL A 1 68  ? 27.556  0.795   23.362  1.00 21.36 ? 68  VAL A CG2 1 
ATOM   552  N  N   . LYS A 1 69  ? 28.198  2.464   20.373  1.00 14.02 ? 69  LYS A N   1 
ATOM   553  C  CA  . LYS A 1 69  ? 29.174  2.235   19.246  1.00 13.53 ? 69  LYS A CA  1 
ATOM   554  C  C   . LYS A 1 69  ? 30.585  1.886   19.713  1.00 12.61 ? 69  LYS A C   1 
ATOM   555  O  O   . LYS A 1 69  ? 31.027  2.517   20.679  1.00 13.85 ? 69  LYS A O   1 
ATOM   556  C  CB  . LYS A 1 69  ? 29.115  3.354   18.225  1.00 18.25 ? 69  LYS A CB  1 
ATOM   557  C  CG  . LYS A 1 69  ? 29.727  4.640   18.610  1.00 22.39 ? 69  LYS A CG  1 
ATOM   558  C  CD  . LYS A 1 69  ? 30.015  5.512   17.405  1.00 29.08 ? 69  LYS A CD  1 
ATOM   559  C  CE  . LYS A 1 69  ? 30.365  6.955   17.849  1.00 37.86 ? 69  LYS A CE  1 
ATOM   560  N  NZ  . LYS A 1 69  ? 29.251  7.990   17.827  1.00 41.10 ? 69  LYS A NZ  1 
ATOM   561  N  N   . LEU A 1 70  ? 31.225  0.966   19.017  1.00 9.99  ? 70  LEU A N   1 
ATOM   562  C  CA  . LEU A 1 70  ? 32.599  0.566   19.267  1.00 11.00 ? 70  LEU A CA  1 
ATOM   563  C  C   . LEU A 1 70  ? 33.410  1.196   18.132  1.00 10.38 ? 70  LEU A C   1 
ATOM   564  O  O   . LEU A 1 70  ? 33.158  0.857   16.966  1.00 9.83  ? 70  LEU A O   1 
ATOM   565  C  CB  . LEU A 1 70  ? 32.776  -0.931  19.360  1.00 11.15 ? 70  LEU A CB  1 
ATOM   566  C  CG  . LEU A 1 70  ? 34.245  -1.391  19.596  1.00 12.66 ? 70  LEU A CG  1 
ATOM   567  C  CD1 . LEU A 1 70  ? 34.797  -0.879  20.922  1.00 14.19 ? 70  LEU A CD1 1 
ATOM   568  C  CD2 . LEU A 1 70  ? 34.219  -2.901  19.541  1.00 14.16 ? 70  LEU A CD2 1 
ATOM   569  N  N   . ASN A 1 71  ? 34.372  2.064   18.401  1.00 10.44 ? 71  ASN A N   1 
ATOM   570  C  CA  . ASN A 1 71  ? 35.278  2.568   17.346  1.00 11.49 ? 71  ASN A CA  1 
ATOM   571  C  C   . ASN A 1 71  ? 36.216  1.495   16.870  1.00 13.63 ? 71  ASN A C   1 
ATOM   572  O  O   . ASN A 1 71  ? 36.717  0.710   17.639  1.00 15.26 ? 71  ASN A O   1 
ATOM   573  C  CB  . ASN A 1 71  ? 36.067  3.763   17.892  1.00 14.24 ? 71  ASN A CB  1 
ATOM   574  C  CG  . ASN A 1 71  ? 35.248  5.015   17.988  1.00 18.66 ? 71  ASN A CG  1 
ATOM   575  O  OD1 . ASN A 1 71  ? 34.033  5.068   17.622  1.00 24.50 ? 71  ASN A OD1 1 
ATOM   576  N  ND2 . ASN A 1 71  ? 35.901  6.075   18.499  1.00 25.50 ? 71  ASN A ND2 1 
ATOM   577  N  N   . LEU A 1 72  ? 36.462  1.463   15.568  1.00 10.87 ? 72  LEU A N   1 
ATOM   578  C  CA  . LEU A 1 72  ? 37.278  0.401   14.963  1.00 10.85 ? 72  LEU A CA  1 
ATOM   579  C  C   . LEU A 1 72  ? 38.389  1.098   14.184  1.00 12.90 ? 72  LEU A C   1 
ATOM   580  O  O   . LEU A 1 72  ? 38.212  2.280   13.705  1.00 13.59 ? 72  LEU A O   1 
ATOM   581  C  CB  . LEU A 1 72  ? 36.433  -0.439  13.963  1.00 10.06 ? 72  LEU A CB  1 
ATOM   582  C  CG  . LEU A 1 72  ? 35.356  -1.211  14.684  1.00 10.92 ? 72  LEU A CG  1 
ATOM   583  C  CD1 . LEU A 1 72  ? 34.466  -1.808  13.604  1.00 9.78  ? 72  LEU A CD1 1 
ATOM   584  C  CD2 . LEU A 1 72  ? 35.874  -2.295  15.645  1.00 10.76 ? 72  LEU A CD2 1 
ATOM   585  N  N   . PRO A 1 73  ? 39.533  0.375   14.033  1.00 13.35 ? 73  PRO A N   1 
ATOM   586  C  CA  . PRO A 1 73  ? 40.700  1.009   13.382  1.00 14.64 ? 73  PRO A CA  1 
ATOM   587  C  C   . PRO A 1 73  ? 40.633  0.878   11.862  1.00 15.74 ? 73  PRO A C   1 
ATOM   588  O  O   . PRO A 1 73  ? 40.063  -0.093  11.332  1.00 16.05 ? 73  PRO A O   1 
ATOM   589  C  CB  . PRO A 1 73  ? 41.855  0.222   13.995  1.00 15.12 ? 73  PRO A CB  1 
ATOM   590  C  CG  . PRO A 1 73  ? 41.311  -1.163  14.133  1.00 12.24 ? 73  PRO A CG  1 
ATOM   591  C  CD  . PRO A 1 73  ? 39.847  -0.974  14.550  1.00 13.70 ? 73  PRO A CD  1 
ATOM   592  N  N   . SER A 1 74  ? 41.176  1.895   11.201  1.00 19.59 ? 74  SER A N   1 
ATOM   593  C  CA  . SER A 1 74  ? 41.078  1.878   9.745   1.00 20.39 ? 74  SER A CA  1 
ATOM   594  C  C   . SER A 1 74  ? 42.003  0.828   9.073   1.00 20.28 ? 74  SER A C   1 
ATOM   595  O  O   . SER A 1 74  ? 41.869  0.594   7.891   1.00 21.60 ? 74  SER A O   1 
ATOM   596  C  CB  . SER A 1 74  ? 41.378  3.239   9.177   1.00 24.04 ? 74  SER A CB  1 
ATOM   597  O  OG  . SER A 1 74  ? 42.663  3.594   9.655   1.00 28.07 ? 74  SER A OG  1 
ATOM   598  N  N   . ASP A 1 75  ? 42.933  0.182   9.776   1.00 18.64 ? 75  ASP A N   1 
ATOM   599  C  CA  . ASP A 1 75  ? 43.568  -1.012  9.149   1.00 17.64 ? 75  ASP A CA  1 
ATOM   600  C  C   . ASP A 1 75  ? 42.684  -2.225  9.008   1.00 15.29 ? 75  ASP A C   1 
ATOM   601  O  O   . ASP A 1 75  ? 43.076  -3.244  8.422   1.00 18.88 ? 75  ASP A O   1 
ATOM   602  C  CB  . ASP A 1 75  ? 44.918  -1.346  9.841   1.00 22.35 ? 75  ASP A CB  1 
ATOM   603  C  CG  . ASP A 1 75  ? 44.742  -1.792  11.237  1.00 24.44 ? 75  ASP A CG  1 
ATOM   604  O  OD1 . ASP A 1 75  ? 44.385  -0.955  12.075  1.00 26.27 ? 75  ASP A OD1 1 
ATOM   605  O  OD2 . ASP A 1 75  ? 45.066  -2.944  11.519  1.00 29.84 ? 75  ASP A OD2 1 
ATOM   606  N  N   . MET A 1 76  ? 41.466  -2.188  9.611   1.00 12.34 ? 76  MET A N   1 
ATOM   607  C  CA  . MET A 1 76  ? 40.523  -3.239  9.490   1.00 10.85 ? 76  MET A CA  1 
ATOM   608  C  C   . MET A 1 76  ? 39.713  -2.931  8.203   1.00 10.36 ? 76  MET A C   1 
ATOM   609  O  O   . MET A 1 76  ? 39.264  -1.796  8.034   1.00 10.84 ? 76  MET A O   1 
ATOM   610  C  CB  . MET A 1 76  ? 39.647  -3.119  10.726  1.00 13.47 ? 76  MET A CB  1 
ATOM   611  C  CG  . MET A 1 76  ? 38.557  -4.036  10.683  1.00 13.59 ? 76  MET A CG  1 
ATOM   612  S  SD  . MET A 1 76  ? 37.772  -4.005  12.392  1.00 14.64 ? 76  MET A SD  1 
ATOM   613  C  CE  . MET A 1 76  ? 36.224  -4.815  11.964  1.00 14.25 ? 76  MET A CE  1 
ATOM   614  N  N   . HIS A 1 77  ? 39.607  -3.907  7.334   1.00 10.92 ? 77  HIS A N   1 
ATOM   615  C  CA  . HIS A 1 77  ? 38.899  -3.609  6.074   1.00 11.36 ? 77  HIS A CA  1 
ATOM   616  C  C   . HIS A 1 77  ? 38.321  -4.820  5.499   1.00 11.48 ? 77  HIS A C   1 
ATOM   617  O  O   . HIS A 1 77  ? 38.660  -5.970  5.822   1.00 12.03 ? 77  HIS A O   1 
ATOM   618  C  CB  . HIS A 1 77  ? 39.770  -2.823  5.059   1.00 12.49 ? 77  HIS A CB  1 
ATOM   619  C  CG  . HIS A 1 77  ? 41.019  -3.533  4.735   1.00 16.43 ? 77  HIS A CG  1 
ATOM   620  N  ND1 . HIS A 1 77  ? 42.161  -3.211  5.299   1.00 18.02 ? 77  HIS A ND1 1 
ATOM   621  C  CD2 . HIS A 1 77  ? 41.254  -4.559  3.883   1.00 18.92 ? 77  HIS A CD2 1 
ATOM   622  C  CE1 . HIS A 1 77  ? 43.117  -4.051  4.848   1.00 17.44 ? 77  HIS A CE1 1 
ATOM   623  N  NE2 . HIS A 1 77  ? 42.570  -4.853  3.962   1.00 20.67 ? 77  HIS A NE2 1 
ATOM   624  N  N   . ILE A 1 78  ? 37.402  -4.572  4.570   1.00 11.83 ? 78  ILE A N   1 
ATOM   625  C  CA  . ILE A 1 78  ? 36.833  -5.560  3.690   1.00 13.82 ? 78  ILE A CA  1 
ATOM   626  C  C   . ILE A 1 78  ? 37.567  -5.597  2.386   1.00 13.83 ? 78  ILE A C   1 
ATOM   627  O  O   . ILE A 1 78  ? 37.783  -4.537  1.786   1.00 14.94 ? 78  ILE A O   1 
ATOM   628  C  CB  . ILE A 1 78  ? 35.321  -5.256  3.422   1.00 14.86 ? 78  ILE A CB  1 
ATOM   629  C  CG1 . ILE A 1 78  ? 34.450  -5.341  4.651   1.00 17.29 ? 78  ILE A CG1 1 
ATOM   630  C  CG2 . ILE A 1 78  ? 34.764  -6.200  2.342   1.00 17.85 ? 78  ILE A CG2 1 
ATOM   631  C  CD1 . ILE A 1 78  ? 33.114  -4.612  4.346   1.00 17.40 ? 78  ILE A CD1 1 
ATOM   632  N  N   A GLN A 1 79  ? 37.961  -6.773  1.931   0.50 15.92 ? 79  GLN A N   1 
ATOM   633  N  N   B GLN A 1 79  ? 37.914  -6.808  1.973   0.50 15.83 ? 79  GLN A N   1 
ATOM   634  C  CA  A GLN A 1 79  ? 38.520  -6.895  0.600   0.50 18.02 ? 79  GLN A CA  1 
ATOM   635  C  CA  B GLN A 1 79  ? 38.499  -7.098  0.687   0.50 18.03 ? 79  GLN A CA  1 
ATOM   636  C  C   A GLN A 1 79  ? 37.517  -7.767  -0.175  0.50 17.42 ? 79  GLN A C   1 
ATOM   637  C  C   B GLN A 1 79  ? 37.417  -7.794  -0.164  0.50 17.20 ? 79  GLN A C   1 
ATOM   638  O  O   A GLN A 1 79  ? 36.865  -8.678  0.373   0.50 18.15 ? 79  GLN A O   1 
ATOM   639  O  O   B GLN A 1 79  ? 36.604  -8.616  0.343   0.50 16.85 ? 79  GLN A O   1 
ATOM   640  C  CB  A GLN A 1 79  ? 39.929  -7.525  0.685   0.50 20.59 ? 79  GLN A CB  1 
ATOM   641  C  CB  B GLN A 1 79  ? 39.713  -8.030  0.913   0.50 20.55 ? 79  GLN A CB  1 
ATOM   642  C  CG  A GLN A 1 79  ? 40.996  -7.008  -0.299  0.50 24.66 ? 79  GLN A CG  1 
ATOM   643  C  CG  B GLN A 1 79  ? 40.659  -8.155  -0.293  0.50 24.55 ? 79  GLN A CG  1 
ATOM   644  C  CD  A GLN A 1 79  ? 41.802  -5.837  0.240   0.50 24.44 ? 79  GLN A CD  1 
ATOM   645  C  CD  B GLN A 1 79  ? 40.170  -9.102  -1.354  0.50 27.01 ? 79  GLN A CD  1 
ATOM   646  O  OE1 A GLN A 1 79  ? 41.295  -4.702  0.382   0.50 25.50 ? 79  GLN A OE1 1 
ATOM   647  O  OE1 B GLN A 1 79  ? 39.480  -10.067 -1.060  0.50 33.14 ? 79  GLN A OE1 1 
ATOM   648  N  NE2 A GLN A 1 79  ? 43.077  -6.101  0.565   0.50 24.46 ? 79  GLN A NE2 1 
ATOM   649  N  NE2 B GLN A 1 79  ? 40.548  -8.846  -2.610  0.50 32.03 ? 79  GLN A NE2 1 
ATOM   650  N  N   . GLY A 1 80  ? 37.359  -7.448  -1.444  1.00 19.99 ? 80  GLY A N   1 
ATOM   651  C  CA  . GLY A 1 80  ? 36.371  -8.127  -2.338  1.00 19.15 ? 80  GLY A CA  1 
ATOM   652  C  C   . GLY A 1 80  ? 35.383  -7.192  -3.062  1.00 19.69 ? 80  GLY A C   1 
ATOM   653  O  O   . GLY A 1 80  ? 34.762  -7.599  -4.095  1.00 22.58 ? 80  GLY A O   1 
ATOM   654  N  N   . LEU A 1 81  ? 35.183  -5.986  -2.554  1.00 18.63 ? 81  LEU A N   1 
ATOM   655  C  CA  . LEU A 1 81  ? 34.373  -4.985  -3.203  1.00 18.39 ? 81  LEU A CA  1 
ATOM   656  C  C   . LEU A 1 81  ? 35.314  -4.310  -4.210  1.00 21.37 ? 81  LEU A C   1 
ATOM   657  O  O   . LEU A 1 81  ? 36.521  -4.679  -4.282  1.00 22.86 ? 81  LEU A O   1 
ATOM   658  C  CB  . LEU A 1 81  ? 33.711  -4.000  -2.212  1.00 16.28 ? 81  LEU A CB  1 
ATOM   659  C  CG  . LEU A 1 81  ? 32.831  -4.686  -1.155  1.00 17.50 ? 81  LEU A CG  1 
ATOM   660  C  CD1 . LEU A 1 81  ? 32.320  -3.719  -0.126  1.00 17.46 ? 81  LEU A CD1 1 
ATOM   661  C  CD2 . LEU A 1 81  ? 31.630  -5.396  -1.831  1.00 17.64 ? 81  LEU A CD2 1 
ATOM   662  N  N   . GLN A 1 82  ? 34.741  -3.402  -4.988  1.00 23.94 ? 82  GLN A N   1 
ATOM   663  C  CA  . GLN A 1 82  ? 35.525  -2.808  -6.105  1.00 27.30 ? 82  GLN A CA  1 
ATOM   664  C  C   . GLN A 1 82  ? 36.679  -1.964  -5.511  1.00 26.42 ? 82  GLN A C   1 
ATOM   665  O  O   . GLN A 1 82  ? 37.875  -1.982  -6.010  1.00 25.55 ? 82  GLN A O   1 
ATOM   666  C  CB  . GLN A 1 82  ? 34.601  -2.026  -7.058  1.00 33.99 ? 82  GLN A CB  1 
ATOM   667  C  CG  . GLN A 1 82  ? 33.563  -1.036  -6.489  1.00 38.53 ? 82  GLN A CG  1 
ATOM   668  C  CD  . GLN A 1 82  ? 32.756  -1.432  -5.198  1.00 51.70 ? 82  GLN A CD  1 
ATOM   669  O  OE1 . GLN A 1 82  ? 32.581  -0.581  -4.306  1.00 57.53 ? 82  GLN A OE1 1 
ATOM   670  N  NE2 . GLN A 1 82  ? 32.216  -2.676  -5.127  1.00 42.78 ? 82  GLN A NE2 1 
ATOM   671  N  N   . SER A 1 83  ? 36.346  -1.344  -4.383  1.00 18.71 ? 83  SER A N   1 
ATOM   672  C  CA  . SER A 1 83  ? 37.311  -0.492  -3.651  1.00 15.99 ? 83  SER A CA  1 
ATOM   673  C  C   . SER A 1 83  ? 37.520  -1.125  -2.301  1.00 14.39 ? 83  SER A C   1 
ATOM   674  O  O   . SER A 1 83  ? 36.669  -1.908  -1.855  1.00 13.22 ? 83  SER A O   1 
ATOM   675  C  CB  . SER A 1 83  ? 36.735  0.814   -3.353  1.00 16.08 ? 83  SER A CB  1 
ATOM   676  O  OG  . SER A 1 83  ? 36.596  1.580   -4.587  1.00 18.63 ? 83  SER A OG  1 
ATOM   677  N  N   . ARG A 1 84  ? 38.593  -0.730  -1.602  1.00 12.74 ? 84  ARG A N   1 
ATOM   678  C  CA  . ARG A 1 84  ? 38.740  -1.221  -0.234  1.00 11.67 ? 84  ARG A CA  1 
ATOM   679  C  C   . ARG A 1 84  ? 37.816  -0.396  0.621   1.00 13.05 ? 84  ARG A C   1 
ATOM   680  O  O   . ARG A 1 84  ? 37.685  0.778   0.492   1.00 11.75 ? 84  ARG A O   1 
ATOM   681  C  CB  . ARG A 1 84  ? 40.174  -0.965  0.223   1.00 12.25 ? 84  ARG A CB  1 
ATOM   682  C  CG  . ARG A 1 84  ? 40.390  -1.382  1.712   1.00 11.92 ? 84  ARG A CG  1 
ATOM   683  C  CD  . ARG A 1 84  ? 41.826  -1.032  2.207   1.00 14.33 ? 84  ARG A CD  1 
ATOM   684  N  NE  . ARG A 1 84  ? 42.640  -2.076  1.733   1.00 12.60 ? 84  ARG A NE  1 
ATOM   685  C  CZ  . ARG A 1 84  ? 43.947  -2.149  2.046   1.00 13.23 ? 84  ARG A CZ  1 
ATOM   686  N  NH1 . ARG A 1 84  ? 44.471  -1.178  2.760   1.00 15.39 ? 84  ARG A NH1 1 
ATOM   687  N  NH2 . ARG A 1 84  ? 44.641  -3.154  1.596   1.00 14.75 ? 84  ARG A NH2 1 
ATOM   688  N  N   . TYR A 1 85  ? 37.083  -1.084  1.530   1.00 9.94  ? 85  TYR A N   1 
ATOM   689  C  CA  . TYR A 1 85  ? 36.293  -0.379  2.527   1.00 10.32 ? 85  TYR A CA  1 
ATOM   690  C  C   . TYR A 1 85  ? 36.831  -0.588  3.945   1.00 8.97  ? 85  TYR A C   1 
ATOM   691  O  O   . TYR A 1 85  ? 36.948  -1.754  4.364   1.00 10.10 ? 85  TYR A O   1 
ATOM   692  C  CB  . TYR A 1 85  ? 34.815  -0.912  2.442   1.00 11.02 ? 85  TYR A CB  1 
ATOM   693  C  CG  . TYR A 1 85  ? 34.092  -0.307  1.288   1.00 9.41  ? 85  TYR A CG  1 
ATOM   694  C  CD1 . TYR A 1 85  ? 33.282  0.805   1.468   1.00 9.18  ? 85  TYR A CD1 1 
ATOM   695  C  CD2 . TYR A 1 85  ? 34.175  -0.889  0.051   1.00 10.65 ? 85  TYR A CD2 1 
ATOM   696  C  CE1 . TYR A 1 85  ? 32.577  1.373   0.334   1.00 9.32  ? 85  TYR A CE1 1 
ATOM   697  C  CE2 . TYR A 1 85  ? 33.535  -0.302  -1.103  1.00 10.63 ? 85  TYR A CE2 1 
ATOM   698  C  CZ  . TYR A 1 85  ? 32.759  0.815   -0.895  1.00 10.59 ? 85  TYR A CZ  1 
ATOM   699  O  OH  . TYR A 1 85  ? 32.069  1.419   -1.949  1.00 15.70 ? 85  TYR A OH  1 
ATOM   700  N  N   . SER A 1 86  ? 37.197  0.458   4.596   1.00 8.88  ? 86  SER A N   1 
ATOM   701  C  CA  . SER A 1 86  ? 37.886  0.360   5.881   1.00 9.79  ? 86  SER A CA  1 
ATOM   702  C  C   . SER A 1 86  ? 36.854  0.538   6.995   1.00 10.23 ? 86  SER A C   1 
ATOM   703  O  O   . SER A 1 86  ? 35.983  1.404   6.910   1.00 9.80  ? 86  SER A O   1 
ATOM   704  C  CB  . SER A 1 86  ? 39.009  1.361   6.019   1.00 11.99 ? 86  SER A CB  1 
ATOM   705  O  OG  . SER A 1 86  ? 39.982  1.014   5.010   1.00 13.55 ? 86  SER A OG  1 
ATOM   706  N  N   . ALA A 1 87  ? 37.036  -0.217  8.076   1.00 8.92  ? 87  ALA A N   1 
ATOM   707  C  CA  . ALA A 1 87  ? 36.095  -0.073  9.201   1.00 9.51  ? 87  ALA A CA  1 
ATOM   708  C  C   . ALA A 1 87  ? 36.189  1.259   9.857   1.00 9.78  ? 87  ALA A C   1 
ATOM   709  O  O   . ALA A 1 87  ? 37.295  1.863   9.958   1.00 11.43 ? 87  ALA A O   1 
ATOM   710  C  CB  . ALA A 1 87  ? 36.377  -1.138  10.238  1.00 11.14 ? 87  ALA A CB  1 
ATOM   711  N  N   . THR A 1 88  ? 35.046  1.680   10.416  1.00 8.79  ? 88  THR A N   1 
ATOM   712  C  CA  . THR A 1 88  ? 34.992  2.887   11.252  1.00 9.25  ? 88  THR A CA  1 
ATOM   713  C  C   . THR A 1 88  ? 34.357  2.624   12.621  1.00 9.53  ? 88  THR A C   1 
ATOM   714  O  O   . THR A 1 88  ? 34.827  3.130   13.619  1.00 10.50 ? 88  THR A O   1 
ATOM   715  C  CB  . THR A 1 88  ? 34.461  4.139   10.529  1.00 11.31 ? 88  THR A CB  1 
ATOM   716  O  OG1 . THR A 1 88  ? 34.484  5.293   11.368  1.00 14.36 ? 88  THR A OG1 1 
ATOM   717  C  CG2 . THR A 1 88  ? 33.045  3.976   10.086  1.00 10.69 ? 88  THR A CG2 1 
ATOM   718  N  N   . GLN A 1 89  ? 33.313  1.797   12.685  1.00 9.42  ? 89  GLN A N   1 
ATOM   719  C  CA  . GLN A 1 89  ? 32.626  1.562   13.971  1.00 9.35  ? 89  GLN A CA  1 
ATOM   720  C  C   . GLN A 1 89  ? 31.671  0.414   13.759  1.00 8.34  ? 89  GLN A C   1 
ATOM   721  O  O   . GLN A 1 89  ? 31.272  0.069   12.645  1.00 8.61  ? 89  GLN A O   1 
ATOM   722  C  CB  . GLN A 1 89  ? 31.852  2.796   14.495  1.00 9.49  ? 89  GLN A CB  1 
ATOM   723  C  CG  . GLN A 1 89  ? 30.874  3.438   13.525  1.00 11.72 ? 89  GLN A CG  1 
ATOM   724  C  CD  . GLN A 1 89  ? 29.455  3.140   13.956  1.00 11.43 ? 89  GLN A CD  1 
ATOM   725  O  OE1 . GLN A 1 89  ? 29.123  2.038   14.231  1.00 11.10 ? 89  GLN A OE1 1 
ATOM   726  N  NE2 . GLN A 1 89  ? 28.636  4.111   13.931  1.00 19.12 ? 89  GLN A NE2 1 
ATOM   727  N  N   . LEU A 1 90  ? 31.332  -0.182  14.882  1.00 6.94  ? 90  LEU A N   1 
ATOM   728  C  CA  . LEU A 1 90  ? 30.178  -1.090  14.941  1.00 6.91  ? 90  LEU A CA  1 
ATOM   729  C  C   . LEU A 1 90  ? 29.201  -0.688  15.986  1.00 6.81  ? 90  LEU A C   1 
ATOM   730  O  O   . LEU A 1 90  ? 29.537  -0.017  16.950  1.00 7.50  ? 90  LEU A O   1 
ATOM   731  C  CB  . LEU A 1 90  ? 30.620  -2.569  14.993  1.00 8.57  ? 90  LEU A CB  1 
ATOM   732  C  CG  . LEU A 1 90  ? 31.368  -3.021  16.291  1.00 7.95  ? 90  LEU A CG  1 
ATOM   733  C  CD1 . LEU A 1 90  ? 30.460  -3.131  17.529  1.00 9.28  ? 90  LEU A CD1 1 
ATOM   734  C  CD2 . LEU A 1 90  ? 32.007  -4.392  15.997  1.00 8.82  ? 90  LEU A CD2 1 
ATOM   735  N  N   . HIS A 1 91  ? 27.946  -1.107  15.853  1.00 6.63  ? 91  HIS A N   1 
ATOM   736  C  CA  . HIS A 1 91  ? 26.870  -0.749  16.828  1.00 6.14  ? 91  HIS A CA  1 
ATOM   737  C  C   . HIS A 1 91  ? 25.735  -1.742  16.622  1.00 6.23  ? 91  HIS A C   1 
ATOM   738  O  O   . HIS A 1 91  ? 25.753  -2.574  15.712  1.00 6.23  ? 91  HIS A O   1 
ATOM   739  C  CB  . HIS A 1 91  ? 26.355  0.674   16.592  1.00 6.41  ? 91  HIS A CB  1 
ATOM   740  C  CG  . HIS A 1 91  ? 25.785  0.855   15.230  1.00 6.16  ? 91  HIS A CG  1 
ATOM   741  N  ND1 . HIS A 1 91  ? 26.540  1.261   14.150  1.00 6.33  ? 91  HIS A ND1 1 
ATOM   742  C  CD2 . HIS A 1 91  ? 24.508  0.558   14.761  1.00 5.74  ? 91  HIS A CD2 1 
ATOM   743  C  CE1 . HIS A 1 91  ? 25.763  1.242   13.009  1.00 6.08  ? 91  HIS A CE1 1 
ATOM   744  N  NE2 . HIS A 1 91  ? 24.526  0.755   13.404  1.00 4.90  ? 91  HIS A NE2 1 
ATOM   745  N  N   . LEU A 1 92  ? 24.727  -1.661  17.491  1.00 6.55  ? 92  LEU A N   1 
ATOM   746  C  CA  . LEU A 1 92  ? 23.639  -2.598  17.482  1.00 6.38  ? 92  LEU A CA  1 
ATOM   747  C  C   . LEU A 1 92  ? 22.280  -1.869  17.480  1.00 5.87  ? 92  LEU A C   1 
ATOM   748  O  O   . LEU A 1 92  ? 22.170  -0.703  17.798  1.00 6.66  ? 92  LEU A O   1 
ATOM   749  C  CB  . LEU A 1 92  ? 23.645  -3.541  18.657  1.00 8.21  ? 92  LEU A CB  1 
ATOM   750  C  CG  . LEU A 1 92  ? 24.860  -4.551  18.609  1.00 8.26  ? 92  LEU A CG  1 
ATOM   751  C  CD1 . LEU A 1 92  ? 25.973  -3.988  19.464  1.00 12.59 ? 92  LEU A CD1 1 
ATOM   752  C  CD2 . LEU A 1 92  ? 24.471  -5.914  19.094  1.00 10.30 ? 92  LEU A CD2 1 
ATOM   753  N  N   . HIS A 1 93  ? 21.250  -2.632  17.091  1.00 5.31  ? 93  HIS A N   1 
ATOM   754  C  CA  . HIS A 1 93  ? 19.820  -2.199  17.175  1.00 5.89  ? 93  HIS A CA  1 
ATOM   755  C  C   . HIS A 1 93  ? 19.071  -3.289  17.856  1.00 5.82  ? 93  HIS A C   1 
ATOM   756  O  O   . HIS A 1 93  ? 19.304  -4.489  17.594  1.00 5.96  ? 93  HIS A O   1 
ATOM   757  C  CB  . HIS A 1 93  ? 19.267  -2.031  15.772  1.00 5.85  ? 93  HIS A CB  1 
ATOM   758  C  CG  . HIS A 1 93  ? 20.031  -1.017  14.969  1.00 5.83  ? 93  HIS A CG  1 
ATOM   759  N  ND1 . HIS A 1 93  ? 19.739  0.337   14.937  1.00 6.04  ? 93  HIS A ND1 1 
ATOM   760  C  CD2 . HIS A 1 93  ? 21.130  -1.197  14.168  1.00 5.55  ? 93  HIS A CD2 1 
ATOM   761  C  CE1 . HIS A 1 93  ? 20.636  0.990   14.149  1.00 6.64  ? 93  HIS A CE1 1 
ATOM   762  N  NE2 . HIS A 1 93  ? 21.469  0.054   13.634  1.00 5.70  ? 93  HIS A NE2 1 
ATOM   763  N  N   . TRP A 1 94  ? 18.096  -2.907  18.635  1.00 5.99  ? 94  TRP A N   1 
ATOM   764  C  CA  . TRP A 1 94  ? 17.311  -3.895  19.416  1.00 6.01  ? 94  TRP A CA  1 
ATOM   765  C  C   . TRP A 1 94  ? 15.947  -3.367  19.693  1.00 6.86  ? 94  TRP A C   1 
ATOM   766  O  O   . TRP A 1 94  ? 15.646  -2.228  19.501  1.00 6.27  ? 94  TRP A O   1 
ATOM   767  C  CB  . TRP A 1 94  ? 18.012  -4.349  20.721  1.00 6.25  ? 94  TRP A CB  1 
ATOM   768  C  CG  . TRP A 1 94  ? 18.337  -3.223  21.618  1.00 6.94  ? 94  TRP A CG  1 
ATOM   769  C  CD1 . TRP A 1 94  ? 17.537  -2.668  22.617  1.00 7.98  ? 94  TRP A CD1 1 
ATOM   770  C  CD2 . TRP A 1 94  ? 19.566  -2.428  21.618  1.00 6.51  ? 94  TRP A CD2 1 
ATOM   771  N  NE1 . TRP A 1 94  ? 18.161  -1.644  23.209  1.00 7.66  ? 94  TRP A NE1 1 
ATOM   772  C  CE2 . TRP A 1 94  ? 19.427  -1.446  22.652  1.00 8.17  ? 94  TRP A CE2 1 
ATOM   773  C  CE3 . TRP A 1 94  ? 20.738  -2.424  20.821  1.00 6.58  ? 94  TRP A CE3 1 
ATOM   774  C  CZ2 . TRP A 1 94  ? 20.389  -0.495  22.949  1.00 7.89  ? 94  TRP A CZ2 1 
ATOM   775  C  CZ3 . TRP A 1 94  ? 21.695  -1.457  21.059  1.00 7.37  ? 94  TRP A CZ3 1 
ATOM   776  C  CH2 . TRP A 1 94  ? 21.553  -0.510  22.130  1.00 8.28  ? 94  TRP A CH2 1 
ATOM   777  N  N   . GLY A 1 95  ? 15.170  -4.255  20.329  1.00 6.14  ? 95  GLY A N   1 
ATOM   778  C  CA  . GLY A 1 95  ? 13.710  -3.984  20.657  1.00 7.99  ? 95  GLY A CA  1 
ATOM   779  C  C   . GLY A 1 95  ? 13.600  -3.616  22.159  1.00 7.54  ? 95  GLY A C   1 
ATOM   780  O  O   . GLY A 1 95  ? 14.246  -2.713  22.720  1.00 8.05  ? 95  GLY A O   1 
ATOM   781  N  N   . ASN A 1 96  ? 12.760  -4.414  22.858  1.00 8.82  ? 96  ASN A N   1 
ATOM   782  C  CA  . ASN A 1 96  ? 12.578  -4.193  24.291  1.00 9.53  ? 96  ASN A CA  1 
ATOM   783  C  C   . ASN A 1 96  ? 12.056  -5.507  24.852  1.00 10.42 ? 96  ASN A C   1 
ATOM   784  O  O   . ASN A 1 96  ? 11.664  -6.402  24.139  1.00 10.31 ? 96  ASN A O   1 
ATOM   785  C  CB  . ASN A 1 96  ? 11.594  -3.034  24.491  1.00 10.99 ? 96  ASN A CB  1 
ATOM   786  C  CG  . ASN A 1 96  ? 10.160  -3.401  24.163  1.00 13.62 ? 96  ASN A CG  1 
ATOM   787  O  OD1 . ASN A 1 96  ? 9.473   -4.000  25.051  1.00 16.44 ? 96  ASN A OD1 1 
ATOM   788  N  ND2 . ASN A 1 96  ? 9.670   -3.083  22.976  1.00 15.40 ? 96  ASN A ND2 1 
ATOM   789  N  N   . PRO A 1 97  ? 12.174  -5.664  26.186  1.00 10.67 ? 97  PRO A N   1 
ATOM   790  C  CA  . PRO A 1 97  ? 11.837  -6.945  26.745  1.00 12.08 ? 97  PRO A CA  1 
ATOM   791  C  C   . PRO A 1 97  ? 10.414  -7.388  26.537  1.00 12.38 ? 97  PRO A C   1 
ATOM   792  O  O   . PRO A 1 97  ? 10.217  -8.568  26.568  1.00 13.44 ? 97  PRO A O   1 
ATOM   793  C  CB  . PRO A 1 97  ? 12.050  -6.699  28.250  1.00 12.59 ? 97  PRO A CB  1 
ATOM   794  C  CG  . PRO A 1 97  ? 13.160  -5.671  28.330  1.00 14.10 ? 97  PRO A CG  1 
ATOM   795  C  CD  . PRO A 1 97  ? 12.819  -4.770  27.172  1.00 12.53 ? 97  PRO A CD  1 
ATOM   796  N  N   . ASN A 1 98  ? 9.482   -6.440  26.383  1.00 12.74 ? 98  ASN A N   1 
ATOM   797  C  CA  . ASN A 1 98  ? 8.091   -6.898  26.058  1.00 14.56 ? 98  ASN A CA  1 
ATOM   798  C  C   . ASN A 1 98  ? 7.832   -7.276  24.612  1.00 14.68 ? 98  ASN A C   1 
ATOM   799  O  O   . ASN A 1 98  ? 6.865   -7.974  24.318  1.00 16.79 ? 98  ASN A O   1 
ATOM   800  C  CB  . ASN A 1 98  ? 7.114   -5.768  26.442  1.00 17.42 ? 98  ASN A CB  1 
ATOM   801  C  CG  . ASN A 1 98  ? 7.093   -5.529  27.950  1.00 25.79 ? 98  ASN A CG  1 
ATOM   802  O  OD1 . ASN A 1 98  ? 7.092   -6.480  28.738  1.00 28.58 ? 98  ASN A OD1 1 
ATOM   803  N  ND2 . ASN A 1 98  ? 6.995   -4.284  28.336  1.00 28.83 ? 98  ASN A ND2 1 
ATOM   804  N  N   . ASP A 1 99  ? 8.726   -6.859  23.694  1.00 12.26 ? 99  ASP A N   1 
ATOM   805  C  CA  . ASP A 1 99  ? 8.613   -7.174  22.273  1.00 12.98 ? 99  ASP A CA  1 
ATOM   806  C  C   . ASP A 1 99  ? 10.085  -7.235  21.745  1.00 10.82 ? 99  ASP A C   1 
ATOM   807  O  O   . ASP A 1 99  ? 10.598  -6.258  21.138  1.00 12.25 ? 99  ASP A O   1 
ATOM   808  C  CB  . ASP A 1 99  ? 7.793   -6.049  21.584  1.00 13.66 ? 99  ASP A CB  1 
ATOM   809  C  CG  . ASP A 1 99  ? 7.264   -6.453  20.242  1.00 18.43 ? 99  ASP A CG  1 
ATOM   810  O  OD1 . ASP A 1 99  ? 7.610   -7.502  19.730  1.00 19.78 ? 99  ASP A OD1 1 
ATOM   811  O  OD2 . ASP A 1 99  ? 6.463   -5.653  19.735  1.00 22.27 ? 99  ASP A OD2 1 
ATOM   812  N  N   . PRO A 1 100 ? 10.757  -8.335  22.008  1.00 10.00 ? 100 PRO A N   1 
ATOM   813  C  CA  . PRO A 1 100 ? 12.206  -8.464  21.812  1.00 10.59 ? 100 PRO A CA  1 
ATOM   814  C  C   . PRO A 1 100 ? 12.539  -8.825  20.392  1.00 10.75 ? 100 PRO A C   1 
ATOM   815  O  O   . PRO A 1 100 ? 13.084  -9.880  20.085  1.00 12.29 ? 100 PRO A O   1 
ATOM   816  C  CB  . PRO A 1 100 ? 12.586  -9.593  22.787  1.00 12.40 ? 100 PRO A CB  1 
ATOM   817  C  CG  . PRO A 1 100 ? 11.358  -10.443 22.798  1.00 12.62 ? 100 PRO A CG  1 
ATOM   818  C  CD  . PRO A 1 100 ? 10.221  -9.485  22.811  1.00 10.55 ? 100 PRO A CD  1 
ATOM   819  N  N   . HIS A 1 101 ? 12.097  -7.938  19.512  1.00 11.06 ? 101 HIS A N   1 
ATOM   820  C  CA  . HIS A 1 101 ? 12.181  -8.182  18.011  1.00 12.02 ? 101 HIS A CA  1 
ATOM   821  C  C   . HIS A 1 101 ? 12.559  -6.940  17.343  1.00 12.57 ? 101 HIS A C   1 
ATOM   822  O  O   . HIS A 1 101 ? 11.747  -6.292  16.639  1.00 17.70 ? 101 HIS A O   1 
ATOM   823  C  CB  . HIS A 1 101 ? 10.825  -8.664  17.455  1.00 14.26 ? 101 HIS A CB  1 
ATOM   824  C  CG  . HIS A 1 101 ? 10.307  -9.835  18.222  1.00 15.80 ? 101 HIS A CG  1 
ATOM   825  N  ND1 . HIS A 1 101 ? 10.867  -11.070 18.178  1.00 16.63 ? 101 HIS A ND1 1 
ATOM   826  C  CD2 . HIS A 1 101 ? 9.302   -9.903  19.177  1.00 16.38 ? 101 HIS A CD2 1 
ATOM   827  C  CE1 . HIS A 1 101 ? 10.184  -11.925 19.008  1.00 19.00 ? 101 HIS A CE1 1 
ATOM   828  N  NE2 . HIS A 1 101 ? 9.231   -11.214 19.591  1.00 18.11 ? 101 HIS A NE2 1 
ATOM   829  N  N   . GLY A 1 102 ? 13.804  -6.550  17.514  1.00 8.80  ? 102 GLY A N   1 
ATOM   830  C  CA  . GLY A 1 102 ? 14.244  -5.240  17.114  1.00 7.65  ? 102 GLY A CA  1 
ATOM   831  C  C   . GLY A 1 102 ? 15.356  -5.164  16.083  1.00 7.06  ? 102 GLY A C   1 
ATOM   832  O  O   . GLY A 1 102 ? 16.061  -4.123  16.010  1.00 8.19  ? 102 GLY A O   1 
ATOM   833  N  N   . SER A 1 103 ? 15.485  -6.161  15.263  1.00 7.62  ? 103 SER A N   1 
ATOM   834  C  CA  . SER A 1 103 ? 16.333  -5.999  14.063  1.00 6.92  ? 103 SER A CA  1 
ATOM   835  C  C   . SER A 1 103 ? 15.758  -4.899  13.158  1.00 7.71  ? 103 SER A C   1 
ATOM   836  O  O   . SER A 1 103 ? 14.590  -4.573  13.232  1.00 9.80  ? 103 SER A O   1 
ATOM   837  C  CB  . SER A 1 103 ? 16.483  -7.300  13.309  1.00 7.17  ? 103 SER A CB  1 
ATOM   838  O  OG  . SER A 1 103 ? 15.253  -7.711  12.676  1.00 6.65  ? 103 SER A OG  1 
ATOM   839  N  N   . GLU A 1 104 ? 16.642  -4.375  12.337  1.00 6.67  ? 104 GLU A N   1 
ATOM   840  C  CA  . GLU A 1 104 ? 16.209  -3.381  11.289  1.00 6.37  ? 104 GLU A CA  1 
ATOM   841  C  C   . GLU A 1 104 ? 15.690  -4.078  10.070  1.00 6.83  ? 104 GLU A C   1 
ATOM   842  O  O   . GLU A 1 104 ? 14.529  -3.879  9.637   1.00 6.49  ? 104 GLU A O   1 
ATOM   843  C  CB  . GLU A 1 104 ? 17.353  -2.411  10.956  1.00 7.15  ? 104 GLU A CB  1 
ATOM   844  C  CG  . GLU A 1 104 ? 17.867  -1.734  12.219  1.00 7.69  ? 104 GLU A CG  1 
ATOM   845  C  CD  . GLU A 1 104 ? 18.237  -0.346  11.892  1.00 8.25  ? 104 GLU A CD  1 
ATOM   846  O  OE1 . GLU A 1 104 ? 19.299  -0.151  11.261  1.00 8.71  ? 104 GLU A OE1 1 
ATOM   847  O  OE2 . GLU A 1 104 ? 17.467  0.614   12.180  1.00 9.31  ? 104 GLU A OE2 1 
ATOM   848  N  N   . HIS A 1 105 ? 16.536  -4.898  9.444   1.00 5.65  ? 105 HIS A N   1 
ATOM   849  C  CA  . HIS A 1 105 ? 16.033  -5.762  8.353   1.00 6.66  ? 105 HIS A CA  1 
ATOM   850  C  C   . HIS A 1 105 ? 15.101  -6.779  8.867   1.00 6.91  ? 105 HIS A C   1 
ATOM   851  O  O   . HIS A 1 105 ? 15.298  -7.350  9.990   1.00 8.09  ? 105 HIS A O   1 
ATOM   852  C  CB  . HIS A 1 105 ? 17.223  -6.355  7.599   1.00 6.41  ? 105 HIS A CB  1 
ATOM   853  C  CG  . HIS A 1 105 ? 18.008  -5.313  6.878   1.00 6.40  ? 105 HIS A CG  1 
ATOM   854  N  ND1 . HIS A 1 105 ? 19.075  -4.627  7.457   1.00 6.92  ? 105 HIS A ND1 1 
ATOM   855  C  CD2 . HIS A 1 105 ? 17.812  -4.765  5.620   1.00 6.25  ? 105 HIS A CD2 1 
ATOM   856  C  CE1 . HIS A 1 105 ? 19.495  -3.700  6.570   1.00 7.83  ? 105 HIS A CE1 1 
ATOM   857  N  NE2 . HIS A 1 105 ? 18.773  -3.813  5.440   1.00 7.41  ? 105 HIS A NE2 1 
ATOM   858  N  N   . THR A 1 106 ? 14.171  -7.200  8.041   1.00 6.63  ? 106 THR A N   1 
ATOM   859  C  CA  . THR A 1 106 ? 13.282  -8.369  8.334   1.00 6.74  ? 106 THR A CA  1 
ATOM   860  C  C   . THR A 1 106 ? 13.453  -9.365  7.228   1.00 6.69  ? 106 THR A C   1 
ATOM   861  O  O   . THR A 1 106 ? 13.940  -9.038  6.148   1.00 7.16  ? 106 THR A O   1 
ATOM   862  C  CB  . THR A 1 106 ? 11.826  -7.924  8.474   1.00 7.27  ? 106 THR A CB  1 
ATOM   863  O  OG1 . THR A 1 106 ? 11.383  -7.327  7.233   1.00 8.82  ? 106 THR A OG1 1 
ATOM   864  C  CG2 . THR A 1 106 ? 11.647  -6.969  9.612   1.00 7.57  ? 106 THR A CG2 1 
ATOM   865  N  N   . VAL A 1 107 ? 13.139  -10.635 7.543   1.00 7.34  ? 107 VAL A N   1 
ATOM   866  C  CA  . VAL A 1 107 ? 13.238  -11.694 6.521   1.00 8.49  ? 107 VAL A CA  1 
ATOM   867  C  C   . VAL A 1 107 ? 11.835  -12.345 6.457   1.00 8.68  ? 107 VAL A C   1 
ATOM   868  O  O   . VAL A 1 107 ? 11.319  -12.768 7.465   1.00 9.24  ? 107 VAL A O   1 
ATOM   869  C  CB  . VAL A 1 107 ? 14.295  -12.739 6.868   1.00 8.66  ? 107 VAL A CB  1 
ATOM   870  C  CG1 . VAL A 1 107 ? 14.270  -13.854 5.851   1.00 9.15  ? 107 VAL A CG1 1 
ATOM   871  C  CG2 . VAL A 1 107 ? 15.716  -12.099 6.949   1.00 9.20  ? 107 VAL A CG2 1 
ATOM   872  N  N   . SER A 1 108 ? 11.208  -12.275 5.284   1.00 9.85  ? 108 SER A N   1 
ATOM   873  C  CA  . SER A 1 108 ? 9.839   -12.778 5.042   1.00 11.26 ? 108 SER A CA  1 
ATOM   874  C  C   . SER A 1 108 ? 8.914   -12.191 6.068   1.00 10.79 ? 108 SER A C   1 
ATOM   875  O  O   . SER A 1 108 ? 8.060   -12.904 6.680   1.00 10.99 ? 108 SER A O   1 
ATOM   876  C  CB  . SER A 1 108 ? 9.847   -14.317 5.121   1.00 13.64 ? 108 SER A CB  1 
ATOM   877  O  OG  . SER A 1 108 ? 10.718  -14.797 4.085   1.00 17.73 ? 108 SER A OG  1 
ATOM   878  N  N   . GLY A 1 109 ? 9.132   -10.908 6.363   1.00 9.26  ? 109 GLY A N   1 
ATOM   879  C  CA  . GLY A 1 109 ? 8.289   -10.108 7.192   1.00 9.64  ? 109 GLY A CA  1 
ATOM   880  C  C   . GLY A 1 109 ? 8.613   -10.201 8.697   1.00 11.04 ? 109 GLY A C   1 
ATOM   881  O  O   . GLY A 1 109 ? 7.970   -9.546  9.479   1.00 12.88 ? 109 GLY A O   1 
ATOM   882  N  N   . GLN A 1 110 ? 9.545   -11.081 9.083   1.00 9.64  ? 110 GLN A N   1 
ATOM   883  C  CA  . GLN A 1 110 ? 9.865   -11.301 10.490  1.00 9.39  ? 110 GLN A CA  1 
ATOM   884  C  C   . GLN A 1 110 ? 11.120  -10.577 10.993  1.00 9.05  ? 110 GLN A C   1 
ATOM   885  O  O   . GLN A 1 110 ? 12.136  -10.576 10.277  1.00 7.86  ? 110 GLN A O   1 
ATOM   886  C  CB  . GLN A 1 110 ? 10.121  -12.793 10.694  1.00 10.31 ? 110 GLN A CB  1 
ATOM   887  C  CG  . GLN A 1 110 ? 9.020   -13.692 10.128  1.00 11.89 ? 110 GLN A CG  1 
ATOM   888  C  CD  . GLN A 1 110 ? 7.609   -13.236 10.531  1.00 12.80 ? 110 GLN A CD  1 
ATOM   889  O  OE1 . GLN A 1 110 ? 6.799   -12.920 9.604   1.00 18.84 ? 110 GLN A OE1 1 
ATOM   890  N  NE2 . GLN A 1 110 ? 7.350   -13.100 11.772  1.00 12.01 ? 110 GLN A NE2 1 
ATOM   891  N  N   . HIS A 1 111 ? 10.981  -9.926  12.115  1.00 9.51  ? 111 HIS A N   1 
ATOM   892  C  CA  . HIS A 1 111 ? 12.152  -9.368  12.753  1.00 9.06  ? 111 HIS A CA  1 
ATOM   893  C  C   . HIS A 1 111 ? 12.944  -10.439 13.428  1.00 9.99  ? 111 HIS A C   1 
ATOM   894  O  O   . HIS A 1 111 ? 12.408  -11.454 13.881  1.00 14.12 ? 111 HIS A O   1 
ATOM   895  C  CB  . HIS A 1 111 ? 11.779  -8.341  13.849  1.00 11.45 ? 111 HIS A CB  1 
ATOM   896  C  CG  . HIS A 1 111 ? 11.404  -7.000  13.310  1.00 10.79 ? 111 HIS A CG  1 
ATOM   897  N  ND1 . HIS A 1 111 ? 10.141  -6.689  12.832  1.00 14.54 ? 111 HIS A ND1 1 
ATOM   898  C  CD2 . HIS A 1 111 ? 12.178  -5.927  13.107  1.00 10.37 ? 111 HIS A CD2 1 
ATOM   899  C  CE1 . HIS A 1 111 ? 10.133  -5.416  12.410  1.00 14.09 ? 111 HIS A CE1 1 
ATOM   900  N  NE2 . HIS A 1 111 ? 11.410  -4.936  12.582  1.00 13.95 ? 111 HIS A NE2 1 
ATOM   901  N  N   . PHE A 1 112 ? 14.219  -10.180 13.594  1.00 8.31  ? 112 PHE A N   1 
ATOM   902  C  CA  . PHE A 1 112 ? 15.080  -10.928 14.496  1.00 9.02  ? 112 PHE A CA  1 
ATOM   903  C  C   . PHE A 1 112 ? 15.161  -10.161 15.781  1.00 7.95  ? 112 PHE A C   1 
ATOM   904  O  O   . PHE A 1 112 ? 14.686  -9.022  15.895  1.00 8.51  ? 112 PHE A O   1 
ATOM   905  C  CB  . PHE A 1 112 ? 16.452  -11.093 13.824  1.00 9.38  ? 112 PHE A CB  1 
ATOM   906  C  CG  . PHE A 1 112 ? 16.421  -12.163 12.828  1.00 11.33 ? 112 PHE A CG  1 
ATOM   907  C  CD1 . PHE A 1 112 ? 16.818  -13.497 13.144  1.00 13.51 ? 112 PHE A CD1 1 
ATOM   908  C  CD2 . PHE A 1 112 ? 15.924  -11.898 11.530  1.00 13.68 ? 112 PHE A CD2 1 
ATOM   909  C  CE1 . PHE A 1 112 ? 16.740  -14.540 12.195  1.00 14.29 ? 112 PHE A CE1 1 
ATOM   910  C  CE2 . PHE A 1 112 ? 15.749  -12.981 10.650  1.00 16.53 ? 112 PHE A CE2 1 
ATOM   911  C  CZ  . PHE A 1 112 ? 16.210  -14.245 10.975  1.00 14.21 ? 112 PHE A CZ  1 
ATOM   912  N  N   . ALA A 1 113 ? 15.778  -10.707 16.822  1.00 7.56  ? 113 ALA A N   1 
ATOM   913  C  CA  . ALA A 1 113 ? 15.829  -10.024 18.089  1.00 7.14  ? 113 ALA A CA  1 
ATOM   914  C  C   . ALA A 1 113 ? 16.587  -8.739  18.051  1.00 6.50  ? 113 ALA A C   1 
ATOM   915  O  O   . ALA A 1 113 ? 16.223  -7.776  18.688  1.00 7.61  ? 113 ALA A O   1 
ATOM   916  C  CB  . ALA A 1 113 ? 16.387  -10.937 19.185  1.00 9.21  ? 113 ALA A CB  1 
ATOM   917  N  N   . ALA A 1 114 ? 17.703  -8.747  17.313  1.00 6.41  ? 114 ALA A N   1 
ATOM   918  C  CA  . ALA A 1 114 ? 18.588  -7.597  17.259  1.00 5.99  ? 114 ALA A CA  1 
ATOM   919  C  C   . ALA A 1 114 ? 19.414  -7.696  16.013  1.00 5.66  ? 114 ALA A C   1 
ATOM   920  O  O   . ALA A 1 114 ? 19.319  -8.651  15.220  1.00 6.10  ? 114 ALA A O   1 
ATOM   921  C  CB  . ALA A 1 114 ? 19.472  -7.573  18.545  1.00 7.15  ? 114 ALA A CB  1 
ATOM   922  N  N   . GLU A 1 115 ? 20.200  -6.648  15.803  1.00 5.70  ? 115 GLU A N   1 
ATOM   923  C  CA  . GLU A 1 115 ? 21.021  -6.649  14.593  1.00 6.27  ? 115 GLU A CA  1 
ATOM   924  C  C   . GLU A 1 115 ? 22.314  -5.852  14.870  1.00 6.61  ? 115 GLU A C   1 
ATOM   925  O  O   . GLU A 1 115 ? 22.253  -4.750  15.469  1.00 7.41  ? 115 GLU A O   1 
ATOM   926  C  CB  . GLU A 1 115 ? 20.215  -6.004  13.452  1.00 6.52  ? 115 GLU A CB  1 
ATOM   927  C  CG  . GLU A 1 115 ? 20.869  -5.999  12.049  1.00 7.26  ? 115 GLU A CG  1 
ATOM   928  C  CD  . GLU A 1 115 ? 19.913  -5.615  10.944  1.00 8.69  ? 115 GLU A CD  1 
ATOM   929  O  OE1 . GLU A 1 115 ? 18.744  -5.875  11.067  1.00 7.86  ? 115 GLU A OE1 1 
ATOM   930  O  OE2 . GLU A 1 115 ? 20.391  -5.115  9.900   1.00 7.91  ? 115 GLU A OE2 1 
ATOM   931  N  N   . LEU A 1 116 ? 23.469  -6.383  14.427  1.00 5.77  ? 116 LEU A N   1 
ATOM   932  C  CA  . LEU A 1 116 ? 24.762  -5.737  14.557  1.00 6.48  ? 116 LEU A CA  1 
ATOM   933  C  C   . LEU A 1 116 ? 25.103  -5.195  13.201  1.00 6.49  ? 116 LEU A C   1 
ATOM   934  O  O   . LEU A 1 116 ? 24.998  -5.879  12.210  1.00 6.39  ? 116 LEU A O   1 
ATOM   935  C  CB  . LEU A 1 116 ? 25.826  -6.812  14.983  1.00 8.01  ? 116 LEU A CB  1 
ATOM   936  C  CG  . LEU A 1 116 ? 27.324  -6.345  14.845  1.00 7.86  ? 116 LEU A CG  1 
ATOM   937  C  CD1 . LEU A 1 116 ? 27.605  -5.442  15.969  1.00 11.10 ? 116 LEU A CD1 1 
ATOM   938  C  CD2 . LEU A 1 116 ? 28.168  -7.607  14.770  1.00 10.81 ? 116 LEU A CD2 1 
ATOM   939  N  N   . HIS A 1 117 ? 25.626  -4.004  13.165  1.00 5.89  ? 117 HIS A N   1 
ATOM   940  C  CA  . HIS A 1 117 ? 26.125  -3.349  11.974  1.00 6.06  ? 117 HIS A CA  1 
ATOM   941  C  C   . HIS A 1 117 ? 27.575  -2.934  12.115  1.00 5.16  ? 117 HIS A C   1 
ATOM   942  O  O   . HIS A 1 117 ? 27.976  -2.370  13.102  1.00 5.56  ? 117 HIS A O   1 
ATOM   943  C  CB  . HIS A 1 117 ? 25.369  -2.068  11.745  1.00 6.03  ? 117 HIS A CB  1 
ATOM   944  C  CG  . HIS A 1 117 ? 23.984  -2.299  11.325  1.00 5.80  ? 117 HIS A CG  1 
ATOM   945  N  ND1 . HIS A 1 117 ? 23.030  -1.347  11.435  1.00 7.67  ? 117 HIS A ND1 1 
ATOM   946  C  CD2 . HIS A 1 117 ? 23.455  -3.406  10.717  1.00 6.88  ? 117 HIS A CD2 1 
ATOM   947  C  CE1 . HIS A 1 117 ? 21.879  -1.911  10.922  1.00 5.49  ? 117 HIS A CE1 1 
ATOM   948  N  NE2 . HIS A 1 117 ? 22.087  -3.164  10.517  1.00 6.53  ? 117 HIS A NE2 1 
ATOM   949  N  N   . ILE A 1 118 ? 28.386  -3.357  11.154  1.00 6.14  ? 118 ILE A N   1 
ATOM   950  C  CA  . ILE A 1 118 ? 29.853  -3.004  11.141  1.00 5.91  ? 118 ILE A CA  1 
ATOM   951  C  C   . ILE A 1 118 ? 29.977  -2.044  9.959   1.00 6.19  ? 118 ILE A C   1 
ATOM   952  O  O   . ILE A 1 118 ? 29.809  -2.417  8.768   1.00 6.61  ? 118 ILE A O   1 
ATOM   953  C  CB  . ILE A 1 118 ? 30.779  -4.194  10.966  1.00 7.08  ? 118 ILE A CB  1 
ATOM   954  C  CG1 . ILE A 1 118 ? 30.426  -5.270  12.007  1.00 7.80  ? 118 ILE A CG1 1 
ATOM   955  C  CG2 . ILE A 1 118 ? 32.220  -3.715  11.197  1.00 7.79  ? 118 ILE A CG2 1 
ATOM   956  C  CD1 . ILE A 1 118 ? 31.271  -6.534  11.854  1.00 9.76  ? 118 ILE A CD1 1 
ATOM   957  N  N   . VAL A 1 119 ? 30.168  -0.790  10.285  1.00 6.33  ? 119 VAL A N   1 
ATOM   958  C  CA  . VAL A 1 119 ? 30.192  0.303   9.268   1.00 7.03  ? 119 VAL A CA  1 
ATOM   959  C  C   . VAL A 1 119 ? 31.602  0.435   8.678   1.00 7.52  ? 119 VAL A C   1 
ATOM   960  O  O   . VAL A 1 119 ? 32.526  0.558   9.483   1.00 8.60  ? 119 VAL A O   1 
ATOM   961  C  CB  . VAL A 1 119 ? 29.753  1.613   9.878   1.00 7.58  ? 119 VAL A CB  1 
ATOM   962  C  CG1 . VAL A 1 119 ? 29.648  2.667   8.798   1.00 9.02  ? 119 VAL A CG1 1 
ATOM   963  C  CG2 . VAL A 1 119 ? 28.373  1.427   10.571  1.00 8.02  ? 119 VAL A CG2 1 
ATOM   964  N  N   . HIS A 1 120 ? 31.676  0.474   7.383   1.00 7.64  ? 120 HIS A N   1 
ATOM   965  C  CA  . HIS A 1 120 ? 32.991  0.746   6.691   1.00 8.42  ? 120 HIS A CA  1 
ATOM   966  C  C   . HIS A 1 120 ? 32.829  1.864   5.693   1.00 9.30  ? 120 HIS A C   1 
ATOM   967  O  O   . HIS A 1 120 ? 31.671  2.167   5.248   1.00 8.84  ? 120 HIS A O   1 
ATOM   968  C  CB  . HIS A 1 120 ? 33.417  -0.465  5.862   1.00 8.68  ? 120 HIS A CB  1 
ATOM   969  C  CG  . HIS A 1 120 ? 33.559  -1.754  6.618   1.00 8.02  ? 120 HIS A CG  1 
ATOM   970  N  ND1 . HIS A 1 120 ? 32.488  -2.425  7.254   1.00 8.25  ? 120 HIS A ND1 1 
ATOM   971  C  CD2 . HIS A 1 120 ? 34.686  -2.479  6.936   1.00 7.82  ? 120 HIS A CD2 1 
ATOM   972  C  CE1 . HIS A 1 120 ? 32.959  -3.576  7.840   1.00 7.76  ? 120 HIS A CE1 1 
ATOM   973  N  NE2 . HIS A 1 120 ? 34.300  -3.648  7.630   1.00 8.26  ? 120 HIS A NE2 1 
ATOM   974  N  N   . TYR A 1 121 ? 33.971  2.521   5.335   1.00 9.48  ? 121 TYR A N   1 
ATOM   975  C  CA  . TYR A 1 121 ? 33.896  3.596   4.327   1.00 10.29 ? 121 TYR A CA  1 
ATOM   976  C  C   . TYR A 1 121 ? 34.918  3.354   3.275   1.00 10.68 ? 121 TYR A C   1 
ATOM   977  O  O   . TYR A 1 121 ? 35.913  2.629   3.503   1.00 10.64 ? 121 TYR A O   1 
ATOM   978  C  CB  . TYR A 1 121 ? 34.188  4.957   4.951   1.00 12.92 ? 121 TYR A CB  1 
ATOM   979  C  CG  . TYR A 1 121 ? 35.607  5.170   5.458   1.00 12.66 ? 121 TYR A CG  1 
ATOM   980  C  CD1 . TYR A 1 121 ? 36.521  5.943   4.707   1.00 16.79 ? 121 TYR A CD1 1 
ATOM   981  C  CD2 . TYR A 1 121 ? 36.037  4.602   6.694   1.00 14.05 ? 121 TYR A CD2 1 
ATOM   982  C  CE1 . TYR A 1 121 ? 37.851  6.055   5.191   1.00 15.64 ? 121 TYR A CE1 1 
ATOM   983  C  CE2 . TYR A 1 121 ? 37.328  4.743   7.155   1.00 18.26 ? 121 TYR A CE2 1 
ATOM   984  C  CZ  . TYR A 1 121 ? 38.209  5.465   6.393   1.00 19.21 ? 121 TYR A CZ  1 
ATOM   985  O  OH  . TYR A 1 121 ? 39.533  5.610   6.885   1.00 21.56 ? 121 TYR A OH  1 
ATOM   986  N  N   . ASN A 1 122 ? 34.684  3.921   2.076   1.00 10.34 ? 122 ASN A N   1 
ATOM   987  C  CA  . ASN A 1 122 ? 35.573  3.711   0.907   1.00 11.52 ? 122 ASN A CA  1 
ATOM   988  C  C   . ASN A 1 122 ? 36.842  4.546   1.113   1.00 12.81 ? 122 ASN A C   1 
ATOM   989  O  O   . ASN A 1 122 ? 36.873  5.730   0.850   1.00 11.60 ? 122 ASN A O   1 
ATOM   990  C  CB  . ASN A 1 122 ? 34.844  4.160   -0.366  1.00 12.24 ? 122 ASN A CB  1 
ATOM   991  C  CG  . ASN A 1 122 ? 35.562  3.804   -1.615  1.00 14.89 ? 122 ASN A CG  1 
ATOM   992  O  OD1 . ASN A 1 122 ? 36.800  3.683   -1.648  1.00 13.02 ? 122 ASN A OD1 1 
ATOM   993  N  ND2 . ASN A 1 122 ? 34.791  3.447   -2.647  1.00 16.03 ? 122 ASN A ND2 1 
ATOM   994  N  N   . SER A 1 123 ? 37.863  3.860   1.627   1.00 10.76 ? 123 SER A N   1 
ATOM   995  C  CA  . SER A 1 123 ? 39.091  4.540   1.903   1.00 12.68 ? 123 SER A CA  1 
ATOM   996  C  C   . SER A 1 123 ? 39.923  4.710   0.656   1.00 13.21 ? 123 SER A C   1 
ATOM   997  O  O   . SER A 1 123 ? 40.859  5.568   0.710   1.00 14.99 ? 123 SER A O   1 
ATOM   998  C  CB  . SER A 1 123 ? 39.889  3.787   2.974   1.00 10.52 ? 123 SER A CB  1 
ATOM   999  O  OG  . SER A 1 123 ? 39.933  2.398   2.699   1.00 10.90 ? 123 SER A OG  1 
ATOM   1000 N  N   . ASP A 1 124 ? 39.643  3.989   -0.418  1.00 12.51 ? 124 ASP A N   1 
ATOM   1001 C  CA  . ASP A 1 124 ? 40.354  4.275   -1.732  1.00 14.52 ? 124 ASP A CA  1 
ATOM   1002 C  C   . ASP A 1 124 ? 39.936  5.601   -2.326  1.00 18.32 ? 124 ASP A C   1 
ATOM   1003 O  O   . ASP A 1 124 ? 40.783  6.243   -3.025  1.00 20.79 ? 124 ASP A O   1 
ATOM   1004 C  CB  . ASP A 1 124 ? 40.017  3.245   -2.710  1.00 14.20 ? 124 ASP A CB  1 
ATOM   1005 C  CG  . ASP A 1 124 ? 40.697  1.952   -2.467  1.00 12.78 ? 124 ASP A CG  1 
ATOM   1006 O  OD1 . ASP A 1 124 ? 41.741  1.943   -1.702  1.00 14.06 ? 124 ASP A OD1 1 
ATOM   1007 O  OD2 . ASP A 1 124 ? 40.324  0.916   -3.013  1.00 14.67 ? 124 ASP A OD2 1 
ATOM   1008 N  N   . LEU A 1 125 ? 38.720  6.041   -2.067  1.00 15.11 ? 125 LEU A N   1 
ATOM   1009 C  CA  . LEU A 1 125 ? 38.190  7.255   -2.720  1.00 15.93 ? 125 LEU A CA  1 
ATOM   1010 C  C   . LEU A 1 125 ? 38.174  8.398   -1.733  1.00 16.29 ? 125 LEU A C   1 
ATOM   1011 O  O   . LEU A 1 125 ? 38.291  9.616   -2.151  1.00 21.52 ? 125 LEU A O   1 
ATOM   1012 C  CB  . LEU A 1 125 ? 36.791  7.019   -3.383  1.00 16.29 ? 125 LEU A CB  1 
ATOM   1013 C  CG  . LEU A 1 125 ? 36.641  6.033   -4.557  1.00 21.07 ? 125 LEU A CG  1 
ATOM   1014 C  CD1 . LEU A 1 125 ? 37.336  4.713   -4.470  1.00 29.35 ? 125 LEU A CD1 1 
ATOM   1015 C  CD2 . LEU A 1 125 ? 35.190  5.791   -5.006  1.00 20.49 ? 125 LEU A CD2 1 
ATOM   1016 N  N   . TYR A 1 126 ? 37.995  8.138   -0.414  1.00 15.05 ? 126 TYR A N   1 
ATOM   1017 C  CA  . TYR A 1 126 ? 37.790  9.183   0.591   1.00 14.98 ? 126 TYR A CA  1 
ATOM   1018 C  C   . TYR A 1 126 ? 38.664  9.102   1.828   1.00 20.39 ? 126 TYR A C   1 
ATOM   1019 O  O   . TYR A 1 126 ? 39.126  8.012   2.181   1.00 18.82 ? 126 TYR A O   1 
ATOM   1020 C  CB  . TYR A 1 126 ? 36.257  9.153   1.083   1.00 17.78 ? 126 TYR A CB  1 
ATOM   1021 C  CG  . TYR A 1 126 ? 35.316  9.158   -0.139  1.00 21.22 ? 126 TYR A CG  1 
ATOM   1022 C  CD1 . TYR A 1 126 ? 35.212  10.272  -0.971  1.00 23.44 ? 126 TYR A CD1 1 
ATOM   1023 C  CD2 . TYR A 1 126 ? 34.606  8.024   -0.497  1.00 19.00 ? 126 TYR A CD2 1 
ATOM   1024 C  CE1 . TYR A 1 126 ? 34.390  10.259  -2.101  1.00 22.73 ? 126 TYR A CE1 1 
ATOM   1025 C  CE2 . TYR A 1 126 ? 33.784  7.998   -1.614  1.00 20.23 ? 126 TYR A CE2 1 
ATOM   1026 C  CZ  . TYR A 1 126 ? 33.673  9.106   -2.424  1.00 24.17 ? 126 TYR A CZ  1 
ATOM   1027 O  OH  . TYR A 1 126 ? 32.834  9.016   -3.528  1.00 22.76 ? 126 TYR A OH  1 
ATOM   1028 N  N   . PRO A 1 127 ? 38.945  10.238  2.477   1.00 19.40 ? 127 PRO A N   1 
ATOM   1029 C  CA  . PRO A 1 127 ? 39.927  10.239  3.554   1.00 21.28 ? 127 PRO A CA  1 
ATOM   1030 C  C   . PRO A 1 127 ? 39.454  9.756   4.881   1.00 23.10 ? 127 PRO A C   1 
ATOM   1031 O  O   . PRO A 1 127 ? 40.297  9.327   5.730   1.00 27.78 ? 127 PRO A O   1 
ATOM   1032 C  CB  . PRO A 1 127 ? 40.339  11.714  3.663   1.00 22.38 ? 127 PRO A CB  1 
ATOM   1033 C  CG  . PRO A 1 127 ? 39.140  12.443  3.158   1.00 22.91 ? 127 PRO A CG  1 
ATOM   1034 C  CD  . PRO A 1 127 ? 38.581  11.606  2.072   1.00 21.69 ? 127 PRO A CD  1 
ATOM   1035 N  N   . ASP A 1 128 ? 38.125  9.801   5.123   1.00 21.02 ? 128 ASP A N   1 
ATOM   1036 C  CA  . ASP A 1 128 ? 37.598  9.391   6.411   1.00 22.38 ? 128 ASP A CA  1 
ATOM   1037 C  C   . ASP A 1 128 ? 36.099  9.081   6.226   1.00 17.48 ? 128 ASP A C   1 
ATOM   1038 O  O   . ASP A 1 128 ? 35.537  9.422   5.208   1.00 17.17 ? 128 ASP A O   1 
ATOM   1039 C  CB  . ASP A 1 128 ? 37.879  10.439  7.543   1.00 24.37 ? 128 ASP A CB  1 
ATOM   1040 C  CG  . ASP A 1 128 ? 37.495  11.831  7.146   1.00 27.82 ? 128 ASP A CG  1 
ATOM   1041 O  OD1 . ASP A 1 128 ? 38.267  12.806  7.296   1.00 33.90 ? 128 ASP A OD1 1 
ATOM   1042 O  OD2 . ASP A 1 128 ? 36.400  11.966  6.644   1.00 23.69 ? 128 ASP A OD2 1 
ATOM   1043 N  N   . ALA A 1 129 ? 35.520  8.463   7.226   1.00 19.20 ? 129 ALA A N   1 
ATOM   1044 C  CA  . ALA A 1 129 ? 34.154  8.016   7.144   1.00 19.18 ? 129 ALA A CA  1 
ATOM   1045 C  C   . ALA A 1 129 ? 33.167  9.165   7.034   1.00 19.84 ? 129 ALA A C   1 
ATOM   1046 O  O   . ALA A 1 129 ? 32.226  9.098   6.235   1.00 17.91 ? 129 ALA A O   1 
ATOM   1047 C  CB  . ALA A 1 129 ? 33.831  7.171   8.357   1.00 20.12 ? 129 ALA A CB  1 
ATOM   1048 N  N   A SER A 1 130 ? 33.343  10.218  7.803   0.50 18.89 ? 130 SER A N   1 
ATOM   1049 N  N   B SER A 1 130 ? 33.418  10.196  7.826   0.50 19.32 ? 130 SER A N   1 
ATOM   1050 C  CA  A SER A 1 130 ? 32.404  11.363  7.700   0.50 18.67 ? 130 SER A CA  1 
ATOM   1051 C  CA  B SER A 1 130 ? 32.496  11.332  7.856   0.50 20.23 ? 130 SER A CA  1 
ATOM   1052 C  C   A SER A 1 130 ? 32.382  11.884  6.261   0.50 19.38 ? 130 SER A C   1 
ATOM   1053 C  C   B SER A 1 130 ? 32.429  12.070  6.516   0.50 20.82 ? 130 SER A C   1 
ATOM   1054 O  O   A SER A 1 130 ? 31.375  11.990  5.571   0.50 16.80 ? 130 SER A O   1 
ATOM   1055 O  O   B SER A 1 130 ? 31.342  12.492  6.175   0.50 19.89 ? 130 SER A O   1 
ATOM   1056 C  CB  A SER A 1 130 ? 32.868  12.465  8.658   0.50 20.52 ? 130 SER A CB  1 
ATOM   1057 C  CB  B SER A 1 130 ? 32.714  12.263  9.081   0.50 22.03 ? 130 SER A CB  1 
ATOM   1058 O  OG  A SER A 1 130 ? 32.149  13.660  8.471   0.50 20.31 ? 130 SER A OG  1 
ATOM   1059 O  OG  B SER A 1 130 ? 34.047  12.712  9.192   0.50 23.57 ? 130 SER A OG  1 
ATOM   1060 N  N   . THR A 1 131 ? 33.562  12.172  5.766   1.00 19.19 ? 131 THR A N   1 
ATOM   1061 C  CA  . THR A 1 131 ? 33.609  12.703  4.405   1.00 20.59 ? 131 THR A CA  1 
ATOM   1062 C  C   . THR A 1 131 ? 32.931  11.752  3.404   1.00 17.75 ? 131 THR A C   1 
ATOM   1063 O  O   . THR A 1 131 ? 32.292  12.176  2.401   1.00 17.19 ? 131 THR A O   1 
ATOM   1064 C  CB  . THR A 1 131 ? 35.078  12.903  3.928   1.00 24.62 ? 131 THR A CB  1 
ATOM   1065 O  OG1 . THR A 1 131 ? 35.746  13.757  4.861   1.00 26.28 ? 131 THR A OG1 1 
ATOM   1066 C  CG2 . THR A 1 131 ? 35.163  13.424  2.467   1.00 20.96 ? 131 THR A CG2 1 
ATOM   1067 N  N   . ALA A 1 132 ? 33.158  10.426  3.531   1.00 16.45 ? 132 ALA A N   1 
ATOM   1068 C  CA  . ALA A 1 132 ? 32.526  9.468   2.619   1.00 15.69 ? 132 ALA A CA  1 
ATOM   1069 C  C   . ALA A 1 132 ? 31.003  9.353   2.757   1.00 13.92 ? 132 ALA A C   1 
ATOM   1070 O  O   . ALA A 1 132 ? 30.426  8.939   1.819   1.00 15.86 ? 132 ALA A O   1 
ATOM   1071 C  CB  . ALA A 1 132 ? 33.094  8.006   2.852   1.00 14.52 ? 132 ALA A CB  1 
ATOM   1072 N  N   . SER A 1 133 ? 30.498  9.694   3.906   1.00 15.67 ? 133 SER A N   1 
ATOM   1073 C  CA  . SER A 1 133 ? 29.119  9.302   4.271   1.00 17.39 ? 133 SER A CA  1 
ATOM   1074 C  C   . SER A 1 133 ? 28.044  9.917   3.358   1.00 19.79 ? 133 SER A C   1 
ATOM   1075 O  O   . SER A 1 133 ? 26.934  9.314   3.213   1.00 17.10 ? 133 SER A O   1 
ATOM   1076 C  CB  . SER A 1 133 ? 28.883  9.626   5.705   1.00 18.48 ? 133 SER A CB  1 
ATOM   1077 O  OG  . SER A 1 133 ? 28.831  11.055  5.905   1.00 19.89 ? 133 SER A OG  1 
ATOM   1078 N  N   A ASN A 1 134 ? 28.295  11.070  2.696   0.50 19.79 ? 134 ASN A N   1 
ATOM   1079 N  N   B ASN A 1 134 ? 28.355  11.075  2.814   0.50 19.57 ? 134 ASN A N   1 
ATOM   1080 C  CA  A ASN A 1 134 ? 27.384  11.628  1.615   0.50 18.96 ? 134 ASN A CA  1 
ATOM   1081 C  CA  B ASN A 1 134 ? 27.491  11.696  1.874   0.50 19.35 ? 134 ASN A CA  1 
ATOM   1082 C  C   A ASN A 1 134 ? 27.814  11.468  0.166   0.50 19.40 ? 134 ASN A C   1 
ATOM   1083 C  C   B ASN A 1 134 ? 28.015  11.698  0.403   0.50 20.03 ? 134 ASN A C   1 
ATOM   1084 O  O   A ASN A 1 134 ? 27.282  12.023  -0.786  0.50 18.44 ? 134 ASN A O   1 
ATOM   1085 O  O   B ASN A 1 134 ? 27.686  12.638  -0.341  0.50 25.25 ? 134 ASN A O   1 
ATOM   1086 C  CB  A ASN A 1 134 ? 27.008  13.094  1.847   0.50 20.04 ? 134 ASN A CB  1 
ATOM   1087 C  CB  B ASN A 1 134 ? 27.027  13.066  2.470   0.50 17.76 ? 134 ASN A CB  1 
ATOM   1088 C  CG  A ASN A 1 134 ? 28.150  14.038  1.532   0.50 19.46 ? 134 ASN A CG  1 
ATOM   1089 C  CG  B ASN A 1 134 ? 28.180  14.043  2.699   0.50 18.65 ? 134 ASN A CG  1 
ATOM   1090 O  OD1 A ASN A 1 134 ? 29.280  13.604  1.414   0.50 18.66 ? 134 ASN A OD1 1 
ATOM   1091 O  OD1 B ASN A 1 134 ? 29.346  13.671  2.577   0.50 20.10 ? 134 ASN A OD1 1 
ATOM   1092 N  ND2 A ASN A 1 134 ? 27.862  15.349  1.471   0.50 19.07 ? 134 ASN A ND2 1 
ATOM   1093 N  ND2 B ASN A 1 134 ? 27.848  15.309  2.986   0.50 18.38 ? 134 ASN A ND2 1 
ATOM   1094 N  N   . LYS A 1 135 ? 28.791  10.666  -0.036  1.00 18.39 ? 135 LYS A N   1 
ATOM   1095 C  CA  . LYS A 1 135 ? 29.333  10.516  -1.361  1.00 19.09 ? 135 LYS A CA  1 
ATOM   1096 C  C   . LYS A 1 135 ? 29.053  9.249   -2.028  1.00 22.04 ? 135 LYS A C   1 
ATOM   1097 O  O   . LYS A 1 135 ? 28.779  8.221   -1.401  1.00 19.90 ? 135 LYS A O   1 
ATOM   1098 C  CB  . LYS A 1 135 ? 30.857  10.757  -1.309  1.00 23.71 ? 135 LYS A CB  1 
ATOM   1099 C  CG  . LYS A 1 135 ? 31.091  12.116  -0.666  1.00 25.12 ? 135 LYS A CG  1 
ATOM   1100 C  CD  . LYS A 1 135 ? 32.170  12.890  -1.351  1.00 27.76 ? 135 LYS A CD  1 
ATOM   1101 C  CE  . LYS A 1 135 ? 32.448  14.215  -0.659  1.00 27.77 ? 135 LYS A CE  1 
ATOM   1102 N  NZ  . LYS A 1 135 ? 31.937  14.468  0.692   1.00 25.02 ? 135 LYS A NZ  1 
ATOM   1103 N  N   . SER A 1 136 ? 29.201  9.273   -3.325  1.00 21.52 ? 136 SER A N   1 
ATOM   1104 C  CA  . SER A 1 136 ? 28.935  8.162   -4.131  1.00 24.12 ? 136 SER A CA  1 
ATOM   1105 C  C   . SER A 1 136 ? 29.819  7.021   -3.662  1.00 23.20 ? 136 SER A C   1 
ATOM   1106 O  O   . SER A 1 136 ? 31.002  7.224   -3.392  1.00 23.67 ? 136 SER A O   1 
ATOM   1107 C  CB  . SER A 1 136 ? 29.360  8.522   -5.562  1.00 26.87 ? 136 SER A CB  1 
ATOM   1108 O  OG  . SER A 1 136 ? 29.118  7.444   -6.429  1.00 34.36 ? 136 SER A OG  1 
ATOM   1109 N  N   . GLU A 1 137 ? 29.245  5.833   -3.583  1.00 26.61 ? 137 GLU A N   1 
ATOM   1110 C  CA  . GLU A 1 137 ? 30.031  4.646   -3.189  1.00 22.50 ? 137 GLU A CA  1 
ATOM   1111 C  C   . GLU A 1 137 ? 30.690  4.822   -1.781  1.00 19.99 ? 137 GLU A C   1 
ATOM   1112 O  O   . GLU A 1 137 ? 31.726  4.172   -1.512  1.00 18.71 ? 137 GLU A O   1 
ATOM   1113 C  CB  . GLU A 1 137 ? 31.089  4.179   -4.227  1.00 29.28 ? 137 GLU A CB  1 
ATOM   1114 C  CG  . GLU A 1 137 ? 30.657  4.029   -5.694  1.00 43.99 ? 137 GLU A CG  1 
ATOM   1115 C  CD  . GLU A 1 137 ? 29.828  2.782   -5.989  1.00 58.08 ? 137 GLU A CD  1 
ATOM   1116 O  OE1 . GLU A 1 137 ? 30.414  1.681   -6.195  1.00 68.95 ? 137 GLU A OE1 1 
ATOM   1117 O  OE2 . GLU A 1 137 ? 28.577  2.910   -6.047  1.00 67.68 ? 137 GLU A OE2 1 
ATOM   1118 N  N   . GLY A 1 138 ? 30.156  5.651   -0.910  1.00 13.61 ? 138 GLY A N   1 
ATOM   1119 C  CA  . GLY A 1 138 ? 30.820  6.094   0.265   1.00 13.54 ? 138 GLY A CA  1 
ATOM   1120 C  C   . GLY A 1 138 ? 31.012  5.009   1.338   1.00 11.92 ? 138 GLY A C   1 
ATOM   1121 O  O   . GLY A 1 138 ? 31.995  4.942   2.043   1.00 11.91 ? 138 GLY A O   1 
ATOM   1122 N  N   . LEU A 1 139 ? 29.933  4.266   1.591   1.00 10.35 ? 139 LEU A N   1 
ATOM   1123 C  CA  . LEU A 1 139 ? 29.897  3.396   2.760   1.00 9.70  ? 139 LEU A CA  1 
ATOM   1124 C  C   . LEU A 1 139 ? 29.492  1.941   2.393   1.00 7.59  ? 139 LEU A C   1 
ATOM   1125 O  O   . LEU A 1 139 ? 28.835  1.634   1.403   1.00 8.65  ? 139 LEU A O   1 
ATOM   1126 C  CB  . LEU A 1 139 ? 28.887  3.864   3.806   1.00 9.59  ? 139 LEU A CB  1 
ATOM   1127 C  CG  . LEU A 1 139 ? 29.079  5.333   4.307   1.00 10.71 ? 139 LEU A CG  1 
ATOM   1128 C  CD1 . LEU A 1 139 ? 27.826  5.753   5.138   1.00 12.57 ? 139 LEU A CD1 1 
ATOM   1129 C  CD2 . LEU A 1 139 ? 30.409  5.450   5.084   1.00 11.58 ? 139 LEU A CD2 1 
ATOM   1130 N  N   . ALA A 1 140 ? 29.927  1.014   3.272   1.00 7.26  ? 140 ALA A N   1 
ATOM   1131 C  CA  . ALA A 1 140 ? 29.541  -0.371  3.162   1.00 7.01  ? 140 ALA A CA  1 
ATOM   1132 C  C   . ALA A 1 140 ? 29.254  -0.839  4.581   1.00 7.44  ? 140 ALA A C   1 
ATOM   1133 O  O   . ALA A 1 140 ? 30.093  -0.698  5.451   1.00 8.59  ? 140 ALA A O   1 
ATOM   1134 C  CB  . ALA A 1 140 ? 30.602  -1.242  2.505   1.00 7.62  ? 140 ALA A CB  1 
ATOM   1135 N  N   . VAL A 1 141 ? 28.081  -1.468  4.833   1.00 6.71  ? 141 VAL A N   1 
ATOM   1136 C  CA  . VAL A 1 141 ? 27.764  -1.903  6.163   1.00 6.47  ? 141 VAL A CA  1 
ATOM   1137 C  C   . VAL A 1 141 ? 27.507  -3.393  6.095   1.00 6.29  ? 141 VAL A C   1 
ATOM   1138 O  O   . VAL A 1 141 ? 26.812  -3.881  5.176   1.00 7.48  ? 141 VAL A O   1 
ATOM   1139 C  CB  . VAL A 1 141 ? 26.523  -1.191  6.703   1.00 5.92  ? 141 VAL A CB  1 
ATOM   1140 C  CG1 . VAL A 1 141 ? 26.252  -1.711  8.148   1.00 7.24  ? 141 VAL A CG1 1 
ATOM   1141 C  CG2 . VAL A 1 141 ? 26.812  0.349   6.709   1.00 7.54  ? 141 VAL A CG2 1 
ATOM   1142 N  N   . LEU A 1 142 ? 28.094  -4.123  7.033   1.00 5.77  ? 142 LEU A N   1 
ATOM   1143 C  CA  . LEU A 1 142 ? 27.842  -5.546  7.213   1.00 6.79  ? 142 LEU A CA  1 
ATOM   1144 C  C   . LEU A 1 142 ? 26.799  -5.673  8.291   1.00 6.50  ? 142 LEU A C   1 
ATOM   1145 O  O   . LEU A 1 142 ? 26.965  -5.023  9.358   1.00 7.95  ? 142 LEU A O   1 
ATOM   1146 C  CB  . LEU A 1 142 ? 29.108  -6.295  7.679   1.00 7.65  ? 142 LEU A CB  1 
ATOM   1147 C  CG  . LEU A 1 142 ? 30.307  -6.106  6.767   1.00 9.06  ? 142 LEU A CG  1 
ATOM   1148 C  CD1 . LEU A 1 142 ? 31.393  -7.038  7.352   1.00 10.71 ? 142 LEU A CD1 1 
ATOM   1149 C  CD2 . LEU A 1 142 ? 29.997  -6.613  5.385   1.00 9.29  ? 142 LEU A CD2 1 
ATOM   1150 N  N   . ALA A 1 143 ? 25.794  -6.470  8.033   1.00 5.60  ? 143 ALA A N   1 
ATOM   1151 C  CA  . ALA A 1 143 ? 24.690  -6.648  9.032   1.00 5.52  ? 143 ALA A CA  1 
ATOM   1152 C  C   . ALA A 1 143 ? 24.573  -8.105  9.399   1.00 5.56  ? 143 ALA A C   1 
ATOM   1153 O  O   . ALA A 1 143 ? 24.497  -9.013  8.534   1.00 6.14  ? 143 ALA A O   1 
ATOM   1154 C  CB  . ALA A 1 143 ? 23.356  -6.176  8.470   1.00 7.84  ? 143 ALA A CB  1 
ATOM   1155 N  N   . VAL A 1 144 ? 24.598  -8.276  10.740  1.00 5.92  ? 144 VAL A N   1 
ATOM   1156 C  CA  . VAL A 1 144 ? 24.405  -9.583  11.337  1.00 6.57  ? 144 VAL A CA  1 
ATOM   1157 C  C   . VAL A 1 144 ? 23.093  -9.626  12.083  1.00 5.87  ? 144 VAL A C   1 
ATOM   1158 O  O   . VAL A 1 144 ? 22.855  -8.841  12.979  1.00 6.12  ? 144 VAL A O   1 
ATOM   1159 C  CB  . VAL A 1 144 ? 25.558  -9.940  12.341  1.00 7.16  ? 144 VAL A CB  1 
ATOM   1160 C  CG1 . VAL A 1 144 ? 25.367  -11.410 12.852  1.00 8.55  ? 144 VAL A CG1 1 
ATOM   1161 C  CG2 . VAL A 1 144 ? 26.915  -9.841  11.655  1.00 7.44  ? 144 VAL A CG2 1 
ATOM   1162 N  N   . LEU A 1 145 ? 22.254  -10.559 11.700  1.00 6.98  ? 145 LEU A N   1 
ATOM   1163 C  CA  . LEU A 1 145 ? 20.962  -10.733 12.408  1.00 7.35  ? 145 LEU A CA  1 
ATOM   1164 C  C   . LEU A 1 145 ? 21.218  -11.567 13.685  1.00 7.31  ? 145 LEU A C   1 
ATOM   1165 O  O   . LEU A 1 145 ? 21.994  -12.531 13.636  1.00 7.98  ? 145 LEU A O   1 
ATOM   1166 C  CB  . LEU A 1 145 ? 19.937  -11.394 11.485  1.00 8.39  ? 145 LEU A CB  1 
ATOM   1167 C  CG  . LEU A 1 145 ? 19.645  -10.696 10.171  1.00 8.93  ? 145 LEU A CG  1 
ATOM   1168 C  CD1 . LEU A 1 145 ? 19.036  -11.635 9.144   1.00 11.44 ? 145 LEU A CD1 1 
ATOM   1169 C  CD2 . LEU A 1 145 ? 18.875  -9.391  10.543  1.00 11.01 ? 145 LEU A CD2 1 
ATOM   1170 N  N   . ILE A 1 146 ? 20.554  -11.213 14.772  1.00 6.99  ? 146 ILE A N   1 
ATOM   1171 C  CA  . ILE A 1 146 ? 20.794  -11.880 16.063  1.00 7.80  ? 146 ILE A CA  1 
ATOM   1172 C  C   . ILE A 1 146 ? 19.531  -12.456 16.599  1.00 7.99  ? 146 ILE A C   1 
ATOM   1173 O  O   . ILE A 1 146 ? 18.515  -11.781 16.594  1.00 7.27  ? 146 ILE A O   1 
ATOM   1174 C  CB  . ILE A 1 146 ? 21.313  -10.826 17.023  1.00 7.33  ? 146 ILE A CB  1 
ATOM   1175 C  CG1 . ILE A 1 146 ? 22.682  -10.287 16.543  1.00 8.40  ? 146 ILE A CG1 1 
ATOM   1176 C  CG2 . ILE A 1 146 ? 21.428  -11.465 18.460  1.00 8.76  ? 146 ILE A CG2 1 
ATOM   1177 C  CD1 . ILE A 1 146 ? 23.149  -9.032  17.346  1.00 8.41  ? 146 ILE A CD1 1 
ATOM   1178 N  N   . GLU A 1 147 ? 19.574  -13.730 17.019  1.00 8.93  ? 147 GLU A N   1 
ATOM   1179 C  CA  . GLU A 1 147 ? 18.388  -14.374 17.650  1.00 9.56  ? 147 GLU A CA  1 
ATOM   1180 C  C   . GLU A 1 147 ? 18.819  -14.881 19.030  1.00 10.77 ? 147 GLU A C   1 
ATOM   1181 O  O   . GLU A 1 147 ? 20.005  -15.061 19.361  1.00 11.24 ? 147 GLU A O   1 
ATOM   1182 C  CB  . GLU A 1 147 ? 17.823  -15.497 16.833  1.00 12.07 ? 147 GLU A CB  1 
ATOM   1183 C  CG  . GLU A 1 147 ? 18.778  -16.678 16.581  1.00 13.80 ? 147 GLU A CG  1 
ATOM   1184 C  CD  . GLU A 1 147 ? 18.332  -17.642 15.485  1.00 18.06 ? 147 GLU A CD  1 
ATOM   1185 O  OE1 . GLU A 1 147 ? 17.317  -17.399 14.764  1.00 20.64 ? 147 GLU A OE1 1 
ATOM   1186 O  OE2 . GLU A 1 147 ? 19.079  -18.644 15.303  1.00 21.79 ? 147 GLU A OE2 1 
ATOM   1187 N  N   . MET A 1 148 ? 17.826  -15.029 19.905  1.00 12.95 ? 148 MET A N   1 
ATOM   1188 C  CA  . MET A 1 148 ? 18.106  -15.728 21.159  1.00 14.56 ? 148 MET A CA  1 
ATOM   1189 C  C   . MET A 1 148 ? 18.475  -17.236 20.978  1.00 12.80 ? 148 MET A C   1 
ATOM   1190 O  O   . MET A 1 148 ? 17.933  -17.962 20.136  1.00 16.55 ? 148 MET A O   1 
ATOM   1191 C  CB  . MET A 1 148 ? 16.849  -15.635 22.052  1.00 16.90 ? 148 MET A CB  1 
ATOM   1192 C  CG  . MET A 1 148 ? 17.196  -16.071 23.490  1.00 19.91 ? 148 MET A CG  1 
ATOM   1193 S  SD  . MET A 1 148 ? 15.812  -15.733 24.641  1.00 36.03 ? 148 MET A SD  1 
ATOM   1194 C  CE  . MET A 1 148 ? 15.570  -13.955 24.696  1.00 28.43 ? 148 MET A CE  1 
ATOM   1195 N  N   . GLY A 1 149 ? 19.449  -17.694 21.738  1.00 13.31 ? 149 GLY A N   1 
ATOM   1196 C  CA  . GLY A 1 149 ? 19.845  -19.099 21.735  1.00 14.66 ? 149 GLY A CA  1 
ATOM   1197 C  C   . GLY A 1 149 ? 20.903  -19.272 22.809  1.00 13.17 ? 149 GLY A C   1 
ATOM   1198 O  O   . GLY A 1 149 ? 20.784  -18.808 23.923  1.00 14.64 ? 149 GLY A O   1 
ATOM   1199 N  N   A SER A 1 150 ? 21.982  -19.911 22.381  0.50 15.18 ? 150 SER A N   1 
ATOM   1200 N  N   B SER A 1 150 ? 21.973  -19.947 22.430  0.50 14.81 ? 150 SER A N   1 
ATOM   1201 C  CA  A SER A 1 150 ? 23.147  -20.096 23.201  0.50 15.17 ? 150 SER A CA  1 
ATOM   1202 C  CA  B SER A 1 150 ? 23.019  -20.218 23.369  0.50 14.57 ? 150 SER A CA  1 
ATOM   1203 C  C   A SER A 1 150 ? 23.810  -18.817 23.668  0.50 14.75 ? 150 SER A C   1 
ATOM   1204 C  C   B SER A 1 150 ? 23.868  -18.974 23.622  0.50 14.05 ? 150 SER A C   1 
ATOM   1205 O  O   A SER A 1 150 ? 23.815  -17.800 22.988  0.50 12.96 ? 150 SER A O   1 
ATOM   1206 O  O   B SER A 1 150 ? 24.023  -18.139 22.727  0.50 12.32 ? 150 SER A O   1 
ATOM   1207 C  CB  A SER A 1 150 ? 24.220  -20.893 22.429  0.50 18.02 ? 150 SER A CB  1 
ATOM   1208 C  CB  B SER A 1 150 ? 23.921  -21.327 22.825  0.50 16.97 ? 150 SER A CB  1 
ATOM   1209 O  OG  A SER A 1 150 ? 23.728  -22.191 22.150  0.50 19.60 ? 150 SER A OG  1 
ATOM   1210 O  OG  B SER A 1 150 ? 24.265  -21.030 21.464  0.50 17.37 ? 150 SER A OG  1 
ATOM   1211 N  N   . PHE A 1 151 ? 24.465  -18.873 24.813  1.00 13.40 ? 151 PHE A N   1 
ATOM   1212 C  CA  . PHE A 1 151 ? 25.371  -17.830 25.212  1.00 14.01 ? 151 PHE A CA  1 
ATOM   1213 C  C   . PHE A 1 151 ? 26.494  -17.696 24.176  1.00 13.30 ? 151 PHE A C   1 
ATOM   1214 O  O   . PHE A 1 151 ? 27.048  -18.712 23.705  1.00 15.68 ? 151 PHE A O   1 
ATOM   1215 C  CB  . PHE A 1 151 ? 25.956  -18.211 26.588  1.00 14.18 ? 151 PHE A CB  1 
ATOM   1216 C  CG  . PHE A 1 151 ? 26.904  -17.256 27.092  1.00 14.84 ? 151 PHE A CG  1 
ATOM   1217 C  CD1 . PHE A 1 151 ? 26.448  -16.090 27.634  1.00 14.48 ? 151 PHE A CD1 1 
ATOM   1218 C  CD2 . PHE A 1 151 ? 28.271  -17.483 27.010  1.00 15.59 ? 151 PHE A CD2 1 
ATOM   1219 C  CE1 . PHE A 1 151 ? 27.359  -15.099 28.047  1.00 14.04 ? 151 PHE A CE1 1 
ATOM   1220 C  CE2 . PHE A 1 151 ? 29.188  -16.545 27.422  1.00 14.60 ? 151 PHE A CE2 1 
ATOM   1221 C  CZ  . PHE A 1 151 ? 28.754  -15.359 27.953  1.00 16.14 ? 151 PHE A CZ  1 
ATOM   1222 N  N   . ASN A 1 152 ? 26.822  -16.449 23.902  1.00 12.20 ? 152 ASN A N   1 
ATOM   1223 C  CA  . ASN A 1 152 ? 27.831  -16.162 22.948  1.00 13.13 ? 152 ASN A CA  1 
ATOM   1224 C  C   . ASN A 1 152 ? 28.999  -15.416 23.565  1.00 14.12 ? 152 ASN A C   1 
ATOM   1225 O  O   . ASN A 1 152 ? 28.960  -14.271 23.888  1.00 12.89 ? 152 ASN A O   1 
ATOM   1226 C  CB  . ASN A 1 152 ? 27.146  -15.373 21.788  1.00 12.22 ? 152 ASN A CB  1 
ATOM   1227 C  CG  . ASN A 1 152 ? 28.068  -15.249 20.597  1.00 12.63 ? 152 ASN A CG  1 
ATOM   1228 O  OD1 . ASN A 1 152 ? 29.282  -14.896 20.725  1.00 13.23 ? 152 ASN A OD1 1 
ATOM   1229 N  ND2 . ASN A 1 152 ? 27.459  -15.415 19.440  1.00 12.27 ? 152 ASN A ND2 1 
ATOM   1230 N  N   . PRO A 1 153 ? 30.090  -16.140 23.893  1.00 13.91 ? 153 PRO A N   1 
ATOM   1231 C  CA  . PRO A 1 153 ? 31.253  -15.503 24.505  1.00 14.68 ? 153 PRO A CA  1 
ATOM   1232 C  C   . PRO A 1 153 ? 31.835  -14.286 23.726  1.00 14.57 ? 153 PRO A C   1 
ATOM   1233 O  O   . PRO A 1 153 ? 32.253  -13.285 24.310  1.00 16.84 ? 153 PRO A O   1 
ATOM   1234 C  CB  . PRO A 1 153 ? 32.271  -16.708 24.594  1.00 15.80 ? 153 PRO A CB  1 
ATOM   1235 C  CG  . PRO A 1 153 ? 31.451  -17.929 24.413  1.00 17.99 ? 153 PRO A CG  1 
ATOM   1236 C  CD  . PRO A 1 153 ? 30.219  -17.583 23.627  1.00 14.43 ? 153 PRO A CD  1 
ATOM   1237 N  N   . SER A 1 154 ? 31.729  -14.338 22.404  1.00 13.11 ? 154 SER A N   1 
ATOM   1238 C  CA  . SER A 1 154 ? 32.320  -13.241 21.625  1.00 13.02 ? 154 SER A CA  1 
ATOM   1239 C  C   . SER A 1 154 ? 31.528  -11.966 21.731  1.00 10.25 ? 154 SER A C   1 
ATOM   1240 O  O   . SER A 1 154 ? 32.093  -10.925 21.891  1.00 11.46 ? 154 SER A O   1 
ATOM   1241 C  CB  . SER A 1 154 ? 32.420  -13.658 20.171  1.00 13.73 ? 154 SER A CB  1 
ATOM   1242 O  OG  . SER A 1 154 ? 33.263  -14.825 20.003  1.00 17.44 ? 154 SER A OG  1 
ATOM   1243 N  N   . TYR A 1 155 ? 30.204  -12.114 21.698  1.00 10.27 ? 155 TYR A N   1 
ATOM   1244 C  CA  . TYR A 1 155 ? 29.403  -10.868 21.904  1.00 10.71 ? 155 TYR A CA  1 
ATOM   1245 C  C   . TYR A 1 155 ? 29.544  -10.352 23.333  1.00 12.36 ? 155 TYR A C   1 
ATOM   1246 O  O   . TYR A 1 155 ? 29.428  -9.143  23.572  1.00 13.63 ? 155 TYR A O   1 
ATOM   1247 C  CB  . TYR A 1 155 ? 27.922  -11.070 21.601  1.00 10.50 ? 155 TYR A CB  1 
ATOM   1248 C  CG  . TYR A 1 155 ? 27.653  -10.925 20.098  1.00 10.37 ? 155 TYR A CG  1 
ATOM   1249 C  CD1 . TYR A 1 155 ? 27.046  -9.783  19.587  1.00 10.32 ? 155 TYR A CD1 1 
ATOM   1250 C  CD2 . TYR A 1 155 ? 28.051  -11.909 19.189  1.00 9.62  ? 155 TYR A CD2 1 
ATOM   1251 C  CE1 . TYR A 1 155 ? 26.814  -9.638  18.229  1.00 9.26  ? 155 TYR A CE1 1 
ATOM   1252 C  CE2 . TYR A 1 155 ? 27.820  -11.767 17.826  1.00 9.24  ? 155 TYR A CE2 1 
ATOM   1253 C  CZ  . TYR A 1 155 ? 27.201  -10.626 17.350  1.00 9.76  ? 155 TYR A CZ  1 
ATOM   1254 O  OH  . TYR A 1 155 ? 26.961  -10.463 16.001  1.00 9.73  ? 155 TYR A OH  1 
ATOM   1255 N  N   . ASP A 1 156 ? 29.824  -11.284 24.261  1.00 13.22 ? 156 ASP A N   1 
ATOM   1256 C  CA  . ASP A 1 156 ? 30.002  -10.823 25.591  1.00 14.79 ? 156 ASP A CA  1 
ATOM   1257 C  C   . ASP A 1 156 ? 31.269  -9.970  25.748  1.00 12.39 ? 156 ASP A C   1 
ATOM   1258 O  O   . ASP A 1 156 ? 31.364  -9.248  26.717  1.00 15.19 ? 156 ASP A O   1 
ATOM   1259 C  CB  . ASP A 1 156 ? 29.946  -11.946 26.623  1.00 17.69 ? 156 ASP A CB  1 
ATOM   1260 C  CG  . ASP A 1 156 ? 28.949  -11.651 27.726  1.00 20.34 ? 156 ASP A CG  1 
ATOM   1261 O  OD1 . ASP A 1 156 ? 27.836  -11.185 27.399  1.00 16.80 ? 156 ASP A OD1 1 
ATOM   1262 O  OD2 . ASP A 1 156 ? 29.277  -11.861 28.912  1.00 25.04 ? 156 ASP A OD2 1 
ATOM   1263 N  N   . LYS A 1 157 ? 32.218  -10.028 24.810  1.00 12.92 ? 157 LYS A N   1 
ATOM   1264 C  CA  . LYS A 1 157 ? 33.366  -9.112  24.805  1.00 13.99 ? 157 LYS A CA  1 
ATOM   1265 C  C   . LYS A 1 157 ? 32.972  -7.617  24.721  1.00 14.77 ? 157 LYS A C   1 
ATOM   1266 O  O   . LYS A 1 157 ? 33.707  -6.735  25.133  1.00 17.90 ? 157 LYS A O   1 
ATOM   1267 C  CB  . LYS A 1 157 ? 34.507  -9.524  23.814  1.00 14.54 ? 157 LYS A CB  1 
ATOM   1268 C  CG  . LYS A 1 157 ? 34.934  -10.991 24.078  1.00 16.06 ? 157 LYS A CG  1 
ATOM   1269 C  CD  . LYS A 1 157 ? 35.846  -11.506 22.966  1.00 18.13 ? 157 LYS A CD  1 
ATOM   1270 C  CE  . LYS A 1 157 ? 36.309  -12.916 23.326  1.00 19.79 ? 157 LYS A CE  1 
ATOM   1271 N  NZ  . LYS A 1 157 ? 37.149  -13.446 22.193  1.00 21.10 ? 157 LYS A NZ  1 
ATOM   1272 N  N   . ILE A 1 158 ? 31.808  -7.363  24.096  1.00 14.36 ? 158 ILE A N   1 
ATOM   1273 C  CA  . ILE A 1 158 ? 31.250  -6.055  24.043  1.00 15.47 ? 158 ILE A CA  1 
ATOM   1274 C  C   . ILE A 1 158 ? 30.251  -5.919  25.178  1.00 13.28 ? 158 ILE A C   1 
ATOM   1275 O  O   . ILE A 1 158 ? 30.318  -4.925  25.931  1.00 14.35 ? 158 ILE A O   1 
ATOM   1276 C  CB  . ILE A 1 158 ? 30.453  -5.876  22.754  1.00 15.92 ? 158 ILE A CB  1 
ATOM   1277 C  CG1 . ILE A 1 158 ? 31.369  -6.075  21.575  1.00 18.37 ? 158 ILE A CG1 1 
ATOM   1278 C  CG2 . ILE A 1 158 ? 29.870  -4.455  22.750  1.00 14.90 ? 158 ILE A CG2 1 
ATOM   1279 C  CD1 . ILE A 1 158 ? 30.615  -6.019  20.242  1.00 20.61 ? 158 ILE A CD1 1 
ATOM   1280 N  N   . PHE A 1 159 ? 29.334  -6.882  25.306  1.00 13.39 ? 159 PHE A N   1 
ATOM   1281 C  CA  . PHE A 1 159 ? 28.300  -6.697  26.331  1.00 13.07 ? 159 PHE A CA  1 
ATOM   1282 C  C   . PHE A 1 159 ? 28.762  -6.543  27.772  1.00 14.77 ? 159 PHE A C   1 
ATOM   1283 O  O   . PHE A 1 159 ? 28.072  -5.817  28.511  1.00 15.18 ? 159 PHE A O   1 
ATOM   1284 C  CB  . PHE A 1 159 ? 27.306  -7.782  26.249  1.00 12.13 ? 159 PHE A CB  1 
ATOM   1285 C  CG  . PHE A 1 159 ? 26.551  -7.915  24.936  1.00 14.33 ? 159 PHE A CG  1 
ATOM   1286 C  CD1 . PHE A 1 159 ? 26.485  -6.906  23.982  1.00 14.91 ? 159 PHE A CD1 1 
ATOM   1287 C  CD2 . PHE A 1 159 ? 25.863  -9.095  24.689  1.00 15.46 ? 159 PHE A CD2 1 
ATOM   1288 C  CE1 . PHE A 1 159 ? 25.760  -7.091  22.807  1.00 13.84 ? 159 PHE A CE1 1 
ATOM   1289 C  CE2 . PHE A 1 159 ? 25.144  -9.286  23.524  1.00 18.01 ? 159 PHE A CE2 1 
ATOM   1290 C  CZ  . PHE A 1 159 ? 25.094  -8.284  22.576  1.00 15.64 ? 159 PHE A CZ  1 
ATOM   1291 N  N   . SER A 1 160 ? 29.899  -7.162  28.128  1.00 15.21 ? 160 SER A N   1 
ATOM   1292 C  CA  . SER A 1 160 ? 30.441  -6.968  29.530  1.00 15.79 ? 160 SER A CA  1 
ATOM   1293 C  C   . SER A 1 160 ? 30.806  -5.545  29.873  1.00 18.01 ? 160 SER A C   1 
ATOM   1294 O  O   . SER A 1 160 ? 31.023  -5.272  31.062  1.00 20.20 ? 160 SER A O   1 
ATOM   1295 C  CB  . SER A 1 160 ? 31.606  -7.900  29.769  1.00 15.56 ? 160 SER A CB  1 
ATOM   1296 O  OG  . SER A 1 160 ? 32.684  -7.691  28.846  1.00 19.14 ? 160 SER A OG  1 
ATOM   1297 N  N   . HIS A 1 161 ? 30.947  -4.657  28.882  1.00 15.60 ? 161 HIS A N   1 
ATOM   1298 C  CA  . HIS A 1 161 ? 31.296  -3.294  29.095  1.00 16.21 ? 161 HIS A CA  1 
ATOM   1299 C  C   . HIS A 1 161 ? 30.100  -2.369  29.074  1.00 16.77 ? 161 HIS A C   1 
ATOM   1300 O  O   . HIS A 1 161 ? 30.255  -1.162  29.304  1.00 14.66 ? 161 HIS A O   1 
ATOM   1301 C  CB  . HIS A 1 161 ? 32.298  -2.777  28.067  1.00 15.90 ? 161 HIS A CB  1 
ATOM   1302 C  CG  . HIS A 1 161 ? 33.595  -3.491  28.098  1.00 19.15 ? 161 HIS A CG  1 
ATOM   1303 N  ND1 . HIS A 1 161 ? 34.611  -3.128  28.928  1.00 21.16 ? 161 HIS A ND1 1 
ATOM   1304 C  CD2 . HIS A 1 161 ? 33.979  -4.637  27.476  1.00 18.17 ? 161 HIS A CD2 1 
ATOM   1305 C  CE1 . HIS A 1 161 ? 35.624  -4.018  28.779  1.00 22.53 ? 161 HIS A CE1 1 
ATOM   1306 N  NE2 . HIS A 1 161 ? 35.251  -4.918  27.870  1.00 20.50 ? 161 HIS A NE2 1 
ATOM   1307 N  N   . LEU A 1 162 ? 28.884  -2.912  28.847  1.00 15.52 ? 162 LEU A N   1 
ATOM   1308 C  CA  . LEU A 1 162 ? 27.740  -1.989  28.673  1.00 15.84 ? 162 LEU A CA  1 
ATOM   1309 C  C   . LEU A 1 162 ? 27.429  -1.213  29.962  1.00 17.38 ? 162 LEU A C   1 
ATOM   1310 O  O   . LEU A 1 162 ? 26.968  -0.072  29.871  1.00 15.01 ? 162 LEU A O   1 
ATOM   1311 C  CB  . LEU A 1 162 ? 26.447  -2.746  28.257  1.00 16.74 ? 162 LEU A CB  1 
ATOM   1312 C  CG  . LEU A 1 162 ? 26.547  -3.285  26.829  1.00 18.25 ? 162 LEU A CG  1 
ATOM   1313 C  CD1 . LEU A 1 162 ? 25.257  -4.041  26.623  1.00 21.48 ? 162 LEU A CD1 1 
ATOM   1314 C  CD2 . LEU A 1 162 ? 26.872  -2.256  25.725  1.00 18.86 ? 162 LEU A CD2 1 
ATOM   1315 N  N   . GLN A 1 163 ? 27.673  -1.807  31.120  1.00 17.69 ? 163 GLN A N   1 
ATOM   1316 C  CA  . GLN A 1 163 ? 27.398  -1.026  32.328  1.00 20.12 ? 163 GLN A CA  1 
ATOM   1317 C  C   . GLN A 1 163 ? 28.232  0.189   32.467  1.00 19.35 ? 163 GLN A C   1 
ATOM   1318 O  O   . GLN A 1 163 ? 27.761  1.138   33.079  1.00 23.05 ? 163 GLN A O   1 
ATOM   1319 C  CB  . GLN A 1 163 ? 27.401  -1.850  33.620  1.00 25.55 ? 163 GLN A CB  1 
ATOM   1320 C  CG  . GLN A 1 163 ? 28.238  -3.118  33.577  1.00 35.16 ? 163 GLN A CG  1 
ATOM   1321 C  CD  . GLN A 1 163 ? 29.722  -2.872  33.638  1.00 41.66 ? 163 GLN A CD  1 
ATOM   1322 O  OE1 . GLN A 1 163 ? 30.395  -2.905  32.598  1.00 39.03 ? 163 GLN A OE1 1 
ATOM   1323 N  NE2 . GLN A 1 163 ? 30.263  -2.658  34.871  1.00 43.97 ? 163 GLN A NE2 1 
ATOM   1324 N  N   . HIS A 1 164 ? 29.377  0.280   31.782  1.00 16.48 ? 164 HIS A N   1 
ATOM   1325 C  CA  . HIS A 1 164 ? 30.176  1.510   31.856  1.00 17.05 ? 164 HIS A CA  1 
ATOM   1326 C  C   . HIS A 1 164 ? 29.814  2.546   30.887  1.00 15.98 ? 164 HIS A C   1 
ATOM   1327 O  O   . HIS A 1 164 ? 30.369  3.627   30.873  1.00 17.64 ? 164 HIS A O   1 
ATOM   1328 C  CB  . HIS A 1 164 ? 31.668  1.209   31.691  1.00 16.57 ? 164 HIS A CB  1 
ATOM   1329 C  CG  . HIS A 1 164 ? 32.248  0.428   32.862  1.00 18.18 ? 164 HIS A CG  1 
ATOM   1330 N  ND1 . HIS A 1 164 ? 31.981  0.774   34.158  1.00 22.22 ? 164 HIS A ND1 1 
ATOM   1331 C  CD2 . HIS A 1 164 ? 33.063  -0.669  32.909  1.00 24.41 ? 164 HIS A CD2 1 
ATOM   1332 C  CE1 . HIS A 1 164 ? 32.615  -0.074  34.987  1.00 21.51 ? 164 HIS A CE1 1 
ATOM   1333 N  NE2 . HIS A 1 164 ? 33.273  -0.952  34.251  1.00 26.54 ? 164 HIS A NE2 1 
ATOM   1334 N  N   . VAL A 1 165 ? 28.852  2.223   29.990  1.00 13.03 ? 165 VAL A N   1 
ATOM   1335 C  CA  . VAL A 1 165 ? 28.362  3.261   29.032  1.00 14.09 ? 165 VAL A CA  1 
ATOM   1336 C  C   . VAL A 1 165 ? 26.852  3.353   29.122  1.00 13.70 ? 165 VAL A C   1 
ATOM   1337 O  O   . VAL A 1 165 ? 26.210  3.717   28.143  1.00 14.62 ? 165 VAL A O   1 
ATOM   1338 C  CB  . VAL A 1 165 ? 28.806  2.907   27.564  1.00 13.63 ? 165 VAL A CB  1 
ATOM   1339 C  CG1 . VAL A 1 165 ? 30.348  3.037   27.505  1.00 16.58 ? 165 VAL A CG1 1 
ATOM   1340 C  CG2 . VAL A 1 165 ? 28.354  1.536   27.122  1.00 14.16 ? 165 VAL A CG2 1 
ATOM   1341 N  N   . LYS A 1 166 ? 26.333  3.198   30.326  1.00 14.39 ? 166 LYS A N   1 
ATOM   1342 C  CA  . LYS A 1 166 ? 24.892  3.323   30.589  1.00 15.98 ? 166 LYS A CA  1 
ATOM   1343 C  C   . LYS A 1 166 ? 24.262  4.589   30.042  1.00 14.68 ? 166 LYS A C   1 
ATOM   1344 O  O   . LYS A 1 166 ? 23.131  4.520   29.540  1.00 15.89 ? 166 LYS A O   1 
ATOM   1345 C  CB  . LYS A 1 166 ? 24.517  3.175   32.062  1.00 22.93 ? 166 LYS A CB  1 
ATOM   1346 C  CG  . LYS A 1 166 ? 24.658  1.756   32.623  1.00 31.70 ? 166 LYS A CG  1 
ATOM   1347 C  CD  . LYS A 1 166 ? 24.002  1.584   34.009  1.00 34.63 ? 166 LYS A CD  1 
ATOM   1348 C  CE  . LYS A 1 166 ? 23.268  2.849   34.422  1.00 34.03 ? 166 LYS A CE  1 
ATOM   1349 N  NZ  . LYS A 1 166 ? 21.811  2.730   34.143  1.00 46.13 ? 166 LYS A NZ  1 
ATOM   1350 N  N   . TYR A 1 167 ? 24.919  5.754   30.221  1.00 12.48 ? 167 TYR A N   1 
ATOM   1351 C  CA  . TYR A 1 167 ? 24.289  7.053   29.910  1.00 13.40 ? 167 TYR A CA  1 
ATOM   1352 C  C   . TYR A 1 167 ? 24.965  7.757   28.743  1.00 13.16 ? 167 TYR A C   1 
ATOM   1353 O  O   . TYR A 1 167 ? 26.150  7.565   28.443  1.00 13.72 ? 167 TYR A O   1 
ATOM   1354 C  CB  . TYR A 1 167 ? 24.341  7.994   31.126  1.00 13.12 ? 167 TYR A CB  1 
ATOM   1355 C  CG  . TYR A 1 167 ? 23.626  7.434   32.323  1.00 14.16 ? 167 TYR A CG  1 
ATOM   1356 C  CD1 . TYR A 1 167 ? 22.238  7.422   32.387  1.00 14.68 ? 167 TYR A CD1 1 
ATOM   1357 C  CD2 . TYR A 1 167 ? 24.350  6.912   33.380  1.00 14.31 ? 167 TYR A CD2 1 
ATOM   1358 C  CE1 . TYR A 1 167 ? 21.590  6.902   33.477  1.00 16.99 ? 167 TYR A CE1 1 
ATOM   1359 C  CE2 . TYR A 1 167 ? 23.700  6.330   34.467  1.00 17.23 ? 167 TYR A CE2 1 
ATOM   1360 C  CZ  . TYR A 1 167 ? 22.309  6.359   34.505  1.00 18.31 ? 167 TYR A CZ  1 
ATOM   1361 O  OH  . TYR A 1 167 ? 21.693  5.813   35.667  1.00 19.25 ? 167 TYR A OH  1 
ATOM   1362 N  N   . LYS A 1 168 ? 24.248  8.669   28.132  1.00 15.49 ? 168 LYS A N   1 
ATOM   1363 C  CA  . LYS A 1 168 ? 24.730  9.397   27.000  1.00 17.23 ? 168 LYS A CA  1 
ATOM   1364 C  C   . LYS A 1 168 ? 25.995  10.137  27.352  1.00 19.10 ? 168 LYS A C   1 
ATOM   1365 O  O   . LYS A 1 168 ? 26.053  10.735  28.395  1.00 16.83 ? 168 LYS A O   1 
ATOM   1366 C  CB  . LYS A 1 168 ? 23.660  10.399  26.584  1.00 19.92 ? 168 LYS A CB  1 
ATOM   1367 C  CG  . LYS A 1 168 ? 24.048  11.165  25.330  1.00 23.04 ? 168 LYS A CG  1 
ATOM   1368 C  CD  . LYS A 1 168 ? 22.969  12.164  24.921  1.00 24.82 ? 168 LYS A CD  1 
ATOM   1369 C  CE  . LYS A 1 168 ? 23.320  12.740  23.569  1.00 31.11 ? 168 LYS A CE  1 
ATOM   1370 N  NZ  . LYS A 1 168 ? 22.003  12.999  22.914  1.00 37.17 ? 168 LYS A NZ  1 
ATOM   1371 N  N   . GLY A 1 169 ? 27.030  10.100  26.507  1.00 18.71 ? 169 GLY A N   1 
ATOM   1372 C  CA  . GLY A 1 169 ? 28.263  10.817  26.805  1.00 22.30 ? 169 GLY A CA  1 
ATOM   1373 C  C   . GLY A 1 169 ? 29.291  9.925   27.508  1.00 23.05 ? 169 GLY A C   1 
ATOM   1374 O  O   . GLY A 1 169 ? 30.453  10.288  27.615  1.00 29.38 ? 169 GLY A O   1 
ATOM   1375 N  N   . GLN A 1 170 ? 28.898  8.732   27.948  1.00 16.99 ? 170 GLN A N   1 
ATOM   1376 C  CA  . GLN A 1 170 ? 29.845  7.920   28.674  1.00 14.81 ? 170 GLN A CA  1 
ATOM   1377 C  C   . GLN A 1 170 ? 30.674  7.050   27.703  1.00 16.74 ? 170 GLN A C   1 
ATOM   1378 O  O   . GLN A 1 170 ? 30.209  6.756   26.582  1.00 17.27 ? 170 GLN A O   1 
ATOM   1379 C  CB  . GLN A 1 170 ? 29.112  7.077   29.714  1.00 12.86 ? 170 GLN A CB  1 
ATOM   1380 C  CG  . GLN A 1 170 ? 28.582  7.892   30.854  1.00 12.98 ? 170 GLN A CG  1 
ATOM   1381 C  CD  . GLN A 1 170 ? 28.035  7.036   31.924  1.00 13.47 ? 170 GLN A CD  1 
ATOM   1382 O  OE1 . GLN A 1 170 ? 27.483  5.940   31.763  1.00 14.21 ? 170 GLN A OE1 1 
ATOM   1383 N  NE2 . GLN A 1 170 ? 28.096  7.612   33.139  1.00 16.26 ? 170 GLN A NE2 1 
ATOM   1384 N  N   A GLU A 1 171 ? 31.891  6.637   28.098  0.50 14.64 ? 171 GLU A N   1 
ATOM   1385 N  N   B GLU A 1 171 ? 31.854  6.605   28.154  0.50 14.52 ? 171 GLU A N   1 
ATOM   1386 C  CA  A GLU A 1 171 ? 32.783  5.880   27.240  0.50 15.97 ? 171 GLU A CA  1 
ATOM   1387 C  CA  B GLU A 1 171 ? 32.753  5.827   27.362  0.50 15.34 ? 171 GLU A CA  1 
ATOM   1388 C  C   A GLU A 1 171 ? 33.576  4.896   28.079  0.50 16.55 ? 171 GLU A C   1 
ATOM   1389 C  C   B GLU A 1 171 ? 33.428  4.732   28.176  0.50 16.10 ? 171 GLU A C   1 
ATOM   1390 O  O   A GLU A 1 171 ? 33.801  5.166   29.301  0.50 17.15 ? 171 GLU A O   1 
ATOM   1391 O  O   B GLU A 1 171 ? 33.481  4.742   29.435  0.50 16.15 ? 171 GLU A O   1 
ATOM   1392 C  CB  A GLU A 1 171 ? 33.733  6.827   26.478  0.50 17.86 ? 171 GLU A CB  1 
ATOM   1393 C  CB  B GLU A 1 171 ? 33.804  6.739   26.711  0.50 17.05 ? 171 GLU A CB  1 
ATOM   1394 C  CG  A GLU A 1 171 ? 33.281  8.275   26.470  0.50 20.25 ? 171 GLU A CG  1 
ATOM   1395 C  CG  B GLU A 1 171 ? 34.787  7.355   27.695  0.50 19.00 ? 171 GLU A CG  1 
ATOM   1396 C  CD  A GLU A 1 171 ? 34.057  9.172   25.500  0.50 22.37 ? 171 GLU A CD  1 
ATOM   1397 C  CD  B GLU A 1 171 ? 35.955  8.013   26.980  0.50 20.23 ? 171 GLU A CD  1 
ATOM   1398 O  OE1 A GLU A 1 171 ? 35.246  9.495   25.778  0.50 21.23 ? 171 GLU A OE1 1 
ATOM   1399 O  OE1 B GLU A 1 171 ? 35.735  8.482   25.823  0.50 23.58 ? 171 GLU A OE1 1 
ATOM   1400 O  OE2 A GLU A 1 171 ? 33.458  9.623   24.506  0.50 23.36 ? 171 GLU A OE2 1 
ATOM   1401 O  OE2 B GLU A 1 171 ? 37.097  8.070   27.553  0.50 19.65 ? 171 GLU A OE2 1 
ATOM   1402 N  N   . ALA A 1 172 ? 33.962  3.775   27.464  1.00 15.60 ? 172 ALA A N   1 
ATOM   1403 C  CA  . ALA A 1 172 ? 34.727  2.728   28.077  1.00 16.54 ? 172 ALA A CA  1 
ATOM   1404 C  C   . ALA A 1 172 ? 35.724  2.279   27.044  1.00 19.74 ? 172 ALA A C   1 
ATOM   1405 O  O   . ALA A 1 172 ? 35.513  2.408   25.818  1.00 18.57 ? 172 ALA A O   1 
ATOM   1406 C  CB  . ALA A 1 172 ? 33.808  1.564   28.459  1.00 18.31 ? 172 ALA A CB  1 
ATOM   1407 N  N   . PHE A 1 173 ? 36.740  1.624   27.511  1.00 19.56 ? 173 PHE A N   1 
ATOM   1408 C  CA  . PHE A 1 173 ? 37.760  1.078   26.663  1.00 20.18 ? 173 PHE A CA  1 
ATOM   1409 C  C   . PHE A 1 173 ? 37.594  -0.423  26.641  1.00 22.38 ? 173 PHE A C   1 
ATOM   1410 O  O   . PHE A 1 173 ? 37.376  -1.083  27.682  1.00 22.37 ? 173 PHE A O   1 
ATOM   1411 C  CB  . PHE A 1 173 ? 39.134  1.570   27.171  1.00 22.64 ? 173 PHE A CB  1 
ATOM   1412 C  CG  . PHE A 1 173 ? 39.507  2.932   26.592  1.00 24.53 ? 173 PHE A CG  1 
ATOM   1413 C  CD1 . PHE A 1 173 ? 39.728  3.077   25.219  1.00 30.18 ? 173 PHE A CD1 1 
ATOM   1414 C  CD2 . PHE A 1 173 ? 39.635  4.052   27.406  1.00 30.58 ? 173 PHE A CD2 1 
ATOM   1415 C  CE1 . PHE A 1 173 ? 40.054  4.306   24.657  1.00 31.38 ? 173 PHE A CE1 1 
ATOM   1416 C  CE2 . PHE A 1 173 ? 39.973  5.284   26.864  1.00 33.99 ? 173 PHE A CE2 1 
ATOM   1417 C  CZ  . PHE A 1 173 ? 40.186  5.412   25.485  1.00 33.31 ? 173 PHE A CZ  1 
ATOM   1418 N  N   . VAL A 1 174 ? 37.545  -0.956  25.409  1.00 17.48 ? 174 VAL A N   1 
ATOM   1419 C  CA  . VAL A 1 174 ? 37.452  -2.343  25.124  1.00 18.94 ? 174 VAL A CA  1 
ATOM   1420 C  C   . VAL A 1 174 ? 38.765  -2.907  24.553  1.00 17.15 ? 174 VAL A C   1 
ATOM   1421 O  O   . VAL A 1 174 ? 39.260  -2.377  23.561  1.00 18.09 ? 174 VAL A O   1 
ATOM   1422 C  CB  . VAL A 1 174 ? 36.293  -2.649  24.122  1.00 16.72 ? 174 VAL A CB  1 
ATOM   1423 C  CG1 . VAL A 1 174 ? 36.166  -4.130  23.950  1.00 17.29 ? 174 VAL A CG1 1 
ATOM   1424 C  CG2 . VAL A 1 174 ? 34.991  -2.053  24.683  1.00 18.96 ? 174 VAL A CG2 1 
ATOM   1425 N  N   . PRO A 1 175 ? 39.346  -3.988  25.184  1.00 20.20 ? 175 PRO A N   1 
ATOM   1426 C  CA  . PRO A 1 175 ? 40.577  -4.601  24.618  1.00 19.81 ? 175 PRO A CA  1 
ATOM   1427 C  C   . PRO A 1 175 ? 40.265  -5.280  23.323  1.00 18.10 ? 175 PRO A C   1 
ATOM   1428 O  O   . PRO A 1 175 ? 39.181  -5.862  23.158  1.00 18.95 ? 175 PRO A O   1 
ATOM   1429 C  CB  . PRO A 1 175 ? 40.937  -5.723  25.611  1.00 22.29 ? 175 PRO A CB  1 
ATOM   1430 C  CG  . PRO A 1 175 ? 40.140  -5.446  26.852  1.00 22.96 ? 175 PRO A CG  1 
ATOM   1431 C  CD  . PRO A 1 175 ? 38.904  -4.642  26.429  1.00 19.47 ? 175 PRO A CD  1 
ATOM   1432 N  N   . GLY A 1 176 ? 41.218  -5.164  22.415  1.00 18.20 ? 176 GLY A N   1 
ATOM   1433 C  CA  . GLY A 1 176 ? 41.018  -5.709  21.073  1.00 17.16 ? 176 GLY A CA  1 
ATOM   1434 C  C   . GLY A 1 176 ? 40.716  -7.150  21.164  1.00 17.24 ? 176 GLY A C   1 
ATOM   1435 O  O   . GLY A 1 176 ? 41.261  -7.864  22.006  1.00 21.01 ? 176 GLY A O   1 
ATOM   1436 N  N   . PHE A 1 177 ? 39.789  -7.624  20.332  1.00 14.72 ? 177 PHE A N   1 
ATOM   1437 C  CA  . PHE A 1 177 ? 39.508  -8.996  20.079  1.00 13.92 ? 177 PHE A CA  1 
ATOM   1438 C  C   . PHE A 1 177 ? 39.167  -9.261  18.613  1.00 12.15 ? 177 PHE A C   1 
ATOM   1439 O  O   . PHE A 1 177 ? 39.163  -8.263  17.858  1.00 13.18 ? 177 PHE A O   1 
ATOM   1440 C  CB  . PHE A 1 177 ? 38.384  -9.521  20.955  1.00 15.23 ? 177 PHE A CB  1 
ATOM   1441 C  CG  . PHE A 1 177 ? 36.987  -8.924  20.639  1.00 13.74 ? 177 PHE A CG  1 
ATOM   1442 C  CD1 . PHE A 1 177 ? 36.031  -9.673  19.881  1.00 14.77 ? 177 PHE A CD1 1 
ATOM   1443 C  CD2 . PHE A 1 177 ? 36.670  -7.602  21.101  1.00 13.31 ? 177 PHE A CD2 1 
ATOM   1444 C  CE1 . PHE A 1 177 ? 34.786  -9.095  19.607  1.00 14.49 ? 177 PHE A CE1 1 
ATOM   1445 C  CE2 . PHE A 1 177 ? 35.404  -7.041  20.773  1.00 16.74 ? 177 PHE A CE2 1 
ATOM   1446 C  CZ  . PHE A 1 177 ? 34.479  -7.827  20.057  1.00 14.59 ? 177 PHE A CZ  1 
ATOM   1447 N  N   . ASN A 1 178 ? 38.957  -10.516 18.240  1.00 13.00 ? 178 ASN A N   1 
ATOM   1448 C  CA  . ASN A 1 178 ? 38.750  -10.822 16.788  1.00 12.83 ? 178 ASN A CA  1 
ATOM   1449 C  C   . ASN A 1 178 ? 37.269  -10.530 16.436  1.00 13.04 ? 178 ASN A C   1 
ATOM   1450 O  O   . ASN A 1 178 ? 36.361  -11.344 16.742  1.00 11.98 ? 178 ASN A O   1 
ATOM   1451 C  CB  . ASN A 1 178 ? 39.100  -12.304 16.491  1.00 14.76 ? 178 ASN A CB  1 
ATOM   1452 C  CG  . ASN A 1 178 ? 38.909  -12.649 15.027  1.00 17.08 ? 178 ASN A CG  1 
ATOM   1453 O  OD1 . ASN A 1 178 ? 38.691  -11.784 14.167  1.00 16.05 ? 178 ASN A OD1 1 
ATOM   1454 N  ND2 . ASN A 1 178 ? 38.973  -13.944 14.716  1.00 18.75 ? 178 ASN A ND2 1 
ATOM   1455 N  N   . ILE A 1 179 ? 37.069  -9.426  15.736  1.00 10.66 ? 179 ILE A N   1 
ATOM   1456 C  CA  . ILE A 1 179 ? 35.725  -9.006  15.411  1.00 11.04 ? 179 ILE A CA  1 
ATOM   1457 C  C   . ILE A 1 179 ? 35.100  -10.040 14.468  1.00 11.20 ? 179 ILE A C   1 
ATOM   1458 O  O   . ILE A 1 179 ? 33.837  -10.174 14.391  1.00 10.56 ? 179 ILE A O   1 
ATOM   1459 C  CB  . ILE A 1 179 ? 35.800  -7.643  14.672  1.00 11.13 ? 179 ILE A CB  1 
ATOM   1460 C  CG1 . ILE A 1 179 ? 36.419  -6.547  15.554  1.00 11.70 ? 179 ILE A CG1 1 
ATOM   1461 C  CG2 . ILE A 1 179 ? 34.378  -7.207  14.193  1.00 11.62 ? 179 ILE A CG2 1 
ATOM   1462 C  CD1 . ILE A 1 179 ? 35.721  -6.364  16.933  1.00 13.86 ? 179 ILE A CD1 1 
ATOM   1463 N  N   . GLU A 1 180 ? 35.851  -10.857 13.733  1.00 11.41 ? 180 GLU A N   1 
ATOM   1464 C  CA  . GLU A 1 180 ? 35.212  -11.825 12.862  1.00 12.30 ? 180 GLU A CA  1 
ATOM   1465 C  C   . GLU A 1 180 ? 34.381  -12.859 13.690  1.00 11.35 ? 180 GLU A C   1 
ATOM   1466 O  O   . GLU A 1 180 ? 33.503  -13.535 13.167  1.00 12.78 ? 180 GLU A O   1 
ATOM   1467 C  CB  . GLU A 1 180 ? 36.267  -12.573 12.033  1.00 15.70 ? 180 GLU A CB  1 
ATOM   1468 C  CG  . GLU A 1 180 ? 35.656  -13.305 10.860  1.00 17.82 ? 180 GLU A CG  1 
ATOM   1469 C  CD  . GLU A 1 180 ? 36.680  -13.825 9.873   1.00 21.33 ? 180 GLU A CD  1 
ATOM   1470 O  OE1 . GLU A 1 180 ? 37.859  -13.406 10.004  1.00 20.90 ? 180 GLU A OE1 1 
ATOM   1471 O  OE2 . GLU A 1 180 ? 36.244  -14.588 9.028   1.00 26.99 ? 180 GLU A OE2 1 
ATOM   1472 N  N   . GLU A 1 181 ? 34.711  -12.991 14.986  1.00 11.73 ? 181 GLU A N   1 
ATOM   1473 C  CA  . GLU A 1 181 ? 33.918  -13.882 15.882  1.00 11.57 ? 181 GLU A CA  1 
ATOM   1474 C  C   . GLU A 1 181 ? 32.464  -13.437 16.058  1.00 11.35 ? 181 GLU A C   1 
ATOM   1475 O  O   . GLU A 1 181 ? 31.656  -14.177 16.526  1.00 11.18 ? 181 GLU A O   1 
ATOM   1476 C  CB  . GLU A 1 181 ? 34.525  -13.941 17.268  1.00 13.65 ? 181 GLU A CB  1 
ATOM   1477 C  CG  . GLU A 1 181 ? 35.941  -14.494 17.397  1.00 17.03 ? 181 GLU A CG  1 
ATOM   1478 C  CD  . GLU A 1 181 ? 36.555  -14.300 18.782  1.00 22.49 ? 181 GLU A CD  1 
ATOM   1479 O  OE1 . GLU A 1 181 ? 35.877  -13.825 19.756  1.00 25.59 ? 181 GLU A OE1 1 
ATOM   1480 O  OE2 . GLU A 1 181 ? 37.781  -14.575 18.910  1.00 23.59 ? 181 GLU A OE2 1 
ATOM   1481 N  N   . LEU A 1 182 ? 32.188  -12.171 15.716  1.00 10.34 ? 182 LEU A N   1 
ATOM   1482 C  CA  . LEU A 1 182 ? 30.812  -11.677 15.748  1.00 9.55  ? 182 LEU A CA  1 
ATOM   1483 C  C   . LEU A 1 182 ? 30.012  -12.055 14.527  1.00 9.26  ? 182 LEU A C   1 
ATOM   1484 O  O   . LEU A 1 182 ? 28.783  -11.876 14.510  1.00 9.33  ? 182 LEU A O   1 
ATOM   1485 C  CB  . LEU A 1 182 ? 30.840  -10.171 15.900  1.00 8.82  ? 182 LEU A CB  1 
ATOM   1486 C  CG  . LEU A 1 182 ? 31.616  -9.617  17.115  1.00 8.77  ? 182 LEU A CG  1 
ATOM   1487 C  CD1 . LEU A 1 182 ? 31.511  -8.119  17.084  1.00 11.02 ? 182 LEU A CD1 1 
ATOM   1488 C  CD2 . LEU A 1 182 ? 31.034  -10.129 18.412  1.00 9.77  ? 182 LEU A CD2 1 
ATOM   1489 N  N   . LEU A 1 183 ? 30.659  -12.566 13.473  1.00 9.27  ? 183 LEU A N   1 
ATOM   1490 C  CA  . LEU A 1 183 ? 29.976  -12.882 12.242  1.00 10.50 ? 183 LEU A CA  1 
ATOM   1491 C  C   . LEU A 1 183 ? 29.387  -14.303 12.315  1.00 11.34 ? 183 LEU A C   1 
ATOM   1492 O  O   . LEU A 1 183 ? 29.914  -15.105 13.090  1.00 12.18 ? 183 LEU A O   1 
ATOM   1493 C  CB  . LEU A 1 183 ? 30.946  -12.803 11.060  1.00 11.71 ? 183 LEU A CB  1 
ATOM   1494 C  CG  . LEU A 1 183 ? 31.638  -11.433 10.875  1.00 12.04 ? 183 LEU A CG  1 
ATOM   1495 C  CD1 . LEU A 1 183 ? 32.590  -11.504 9.694   1.00 15.91 ? 183 LEU A CD1 1 
ATOM   1496 C  CD2 . LEU A 1 183 ? 30.610  -10.301 10.744  1.00 13.86 ? 183 LEU A CD2 1 
ATOM   1497 N  N   . PRO A 1 184 ? 28.367  -14.614 11.557  1.00 9.46  ? 184 PRO A N   1 
ATOM   1498 C  CA  . PRO A 1 184 ? 27.714  -15.858 11.589  1.00 11.30 ? 184 PRO A CA  1 
ATOM   1499 C  C   . PRO A 1 184 ? 28.465  -16.911 10.781  1.00 13.54 ? 184 PRO A C   1 
ATOM   1500 O  O   . PRO A 1 184 ? 29.552  -16.664 10.181  1.00 14.37 ? 184 PRO A O   1 
ATOM   1501 C  CB  . PRO A 1 184 ? 26.302  -15.510 11.027  1.00 12.53 ? 184 PRO A CB  1 
ATOM   1502 C  CG  . PRO A 1 184 ? 26.689  -14.449 9.976   1.00 10.96 ? 184 PRO A CG  1 
ATOM   1503 C  CD  . PRO A 1 184 ? 27.671  -13.616 10.682  1.00 9.86  ? 184 PRO A CD  1 
ATOM   1504 N  N   . GLU A 1 185 ? 27.891  -18.100 10.845  1.00 15.78 ? 185 GLU A N   1 
ATOM   1505 C  CA  . GLU A 1 185 ? 28.322  -19.220 9.996   1.00 16.73 ? 185 GLU A CA  1 
ATOM   1506 C  C   . GLU A 1 185 ? 28.104  -18.893 8.552   1.00 16.74 ? 185 GLU A C   1 
ATOM   1507 O  O   . GLU A 1 185 ? 27.106  -18.162 8.206   1.00 16.31 ? 185 GLU A O   1 
ATOM   1508 C  CB  . GLU A 1 185 ? 27.404  -20.391 10.324  1.00 21.40 ? 185 GLU A CB  1 
ATOM   1509 C  CG  . GLU A 1 185 ? 27.756  -20.986 11.688  1.00 29.84 ? 185 GLU A CG  1 
ATOM   1510 C  CD  . GLU A 1 185 ? 29.266  -21.186 11.866  1.00 37.10 ? 185 GLU A CD  1 
ATOM   1511 O  OE1 . GLU A 1 185 ? 29.804  -22.137 11.274  1.00 38.86 ? 185 GLU A OE1 1 
ATOM   1512 O  OE2 . GLU A 1 185 ? 29.916  -20.377 12.567  1.00 39.71 ? 185 GLU A OE2 1 
ATOM   1513 N  N   . ARG A 1 186 ? 29.019  -19.382 7.678   1.00 14.82 ? 186 ARG A N   1 
ATOM   1514 C  CA  . ARG A 1 186 ? 28.803  -19.331 6.243   1.00 16.60 ? 186 ARG A CA  1 
ATOM   1515 C  C   . ARG A 1 186 ? 28.550  -17.845 5.795   1.00 13.47 ? 186 ARG A C   1 
ATOM   1516 O  O   . ARG A 1 186 ? 27.571  -17.493 5.072   1.00 14.65 ? 186 ARG A O   1 
ATOM   1517 C  CB  . ARG A 1 186 ? 27.692  -20.316 5.815   1.00 19.52 ? 186 ARG A CB  1 
ATOM   1518 C  CG  . ARG A 1 186 ? 28.098  -21.761 6.091   1.00 24.15 ? 186 ARG A CG  1 
ATOM   1519 C  CD  . ARG A 1 186 ? 27.051  -22.747 5.570   1.00 23.30 ? 186 ARG A CD  1 
ATOM   1520 N  NE  . ARG A 1 186 ? 25.659  -22.555 6.009   1.00 28.66 ? 186 ARG A NE  1 
ATOM   1521 C  CZ  . ARG A 1 186 ? 25.200  -22.799 7.240   1.00 31.30 ? 186 ARG A CZ  1 
ATOM   1522 N  NH1 . ARG A 1 186 ? 26.020  -23.138 8.236   1.00 33.91 ? 186 ARG A NH1 1 
ATOM   1523 N  NH2 . ARG A 1 186 ? 23.907  -22.649 7.486   1.00 32.17 ? 186 ARG A NH2 1 
ATOM   1524 N  N   . THR A 1 187 ? 29.538  -17.058 6.146   1.00 11.85 ? 187 THR A N   1 
ATOM   1525 C  CA  . THR A 1 187 ? 29.527  -15.704 5.679   1.00 12.77 ? 187 THR A CA  1 
ATOM   1526 C  C   . THR A 1 187 ? 29.547  -15.576 4.162   1.00 12.21 ? 187 THR A C   1 
ATOM   1527 O  O   . THR A 1 187 ? 29.231  -14.522 3.660   1.00 12.97 ? 187 THR A O   1 
ATOM   1528 C  CB  . THR A 1 187 ? 30.646  -14.823 6.221   1.00 12.22 ? 187 THR A CB  1 
ATOM   1529 O  OG1 . THR A 1 187 ? 31.892  -15.480 6.067   1.00 15.01 ? 187 THR A OG1 1 
ATOM   1530 C  CG2 . THR A 1 187 ? 30.534  -14.557 7.748   1.00 12.04 ? 187 THR A CG2 1 
ATOM   1531 N  N   . ALA A 1 188 ? 29.902  -16.626 3.415   1.00 12.34 ? 188 ALA A N   1 
ATOM   1532 C  CA  . ALA A 1 188 ? 29.697  -16.632 1.956   1.00 13.93 ? 188 ALA A CA  1 
ATOM   1533 C  C   . ALA A 1 188 ? 28.240  -16.403 1.515   1.00 12.46 ? 188 ALA A C   1 
ATOM   1534 O  O   . ALA A 1 188 ? 28.024  -15.976 0.410   1.00 12.49 ? 188 ALA A O   1 
ATOM   1535 C  CB  . ALA A 1 188 ? 30.260  -17.948 1.322   1.00 14.94 ? 188 ALA A CB  1 
ATOM   1536 N  N   . GLU A 1 189 ? 27.282  -16.655 2.426   1.00 12.08 ? 189 GLU A N   1 
ATOM   1537 C  CA  . GLU A 1 189 ? 25.847  -16.584 2.088   1.00 11.43 ? 189 GLU A CA  1 
ATOM   1538 C  C   . GLU A 1 189 ? 25.328  -15.228 2.615   1.00 9.39  ? 189 GLU A C   1 
ATOM   1539 O  O   . GLU A 1 189 ? 25.316  -14.972 3.815   1.00 9.68  ? 189 GLU A O   1 
ATOM   1540 C  CB  . GLU A 1 189 ? 25.072  -17.723 2.779   1.00 13.69 ? 189 GLU A CB  1 
ATOM   1541 C  CG  . GLU A 1 189 ? 25.524  -19.117 2.260   1.00 17.37 ? 189 GLU A CG  1 
ATOM   1542 C  CD  . GLU A 1 189 ? 25.002  -20.308 3.086   1.00 25.11 ? 189 GLU A CD  1 
ATOM   1543 O  OE1 . GLU A 1 189 ? 24.245  -20.126 4.091   1.00 26.12 ? 189 GLU A OE1 1 
ATOM   1544 O  OE2 . GLU A 1 189 ? 25.432  -21.491 2.752   1.00 29.22 ? 189 GLU A OE2 1 
ATOM   1545 N  N   . TYR A 1 190 ? 24.949  -14.361 1.683   1.00 9.19  ? 190 TYR A N   1 
ATOM   1546 C  CA  . TYR A 1 190 ? 24.464  -13.030 2.062   1.00 8.72  ? 190 TYR A CA  1 
ATOM   1547 C  C   . TYR A 1 190 ? 23.521  -12.417 1.068   1.00 8.70  ? 190 TYR A C   1 
ATOM   1548 O  O   . TYR A 1 190 ? 23.453  -12.819 -0.094  1.00 8.54  ? 190 TYR A O   1 
ATOM   1549 C  CB  . TYR A 1 190 ? 25.630  -12.009 2.335   1.00 9.29  ? 190 TYR A CB  1 
ATOM   1550 C  CG  . TYR A 1 190 ? 26.598  -11.866 1.163   1.00 9.71  ? 190 TYR A CG  1 
ATOM   1551 C  CD1 . TYR A 1 190 ? 26.308  -10.940 0.164   1.00 8.82  ? 190 TYR A CD1 1 
ATOM   1552 C  CD2 . TYR A 1 190 ? 27.784  -12.618 1.103   1.00 8.94  ? 190 TYR A CD2 1 
ATOM   1553 C  CE1 . TYR A 1 190 ? 27.198  -10.745 -0.919  1.00 10.66 ? 190 TYR A CE1 1 
ATOM   1554 C  CE2 . TYR A 1 190 ? 28.697  -12.397 0.054   1.00 9.09  ? 190 TYR A CE2 1 
ATOM   1555 C  CZ  . TYR A 1 190 ? 28.391  -11.502 -0.903  1.00 9.14  ? 190 TYR A CZ  1 
ATOM   1556 O  OH  . TYR A 1 190 ? 29.314  -11.271 -2.006  1.00 12.22 ? 190 TYR A OH  1 
ATOM   1557 N  N   . TYR A 1 191 ? 22.788  -11.425 1.518   1.00 8.10  ? 191 TYR A N   1 
ATOM   1558 C  CA  . TYR A 1 191 ? 21.928  -10.548 0.750   1.00 7.49  ? 191 TYR A CA  1 
ATOM   1559 C  C   . TYR A 1 191 ? 22.706  -9.252  0.496   1.00 8.20  ? 191 TYR A C   1 
ATOM   1560 O  O   . TYR A 1 191 ? 23.465  -8.786  1.358   1.00 8.98  ? 191 TYR A O   1 
ATOM   1561 C  CB  . TYR A 1 191 ? 20.633  -10.170 1.497   1.00 9.11  ? 191 TYR A CB  1 
ATOM   1562 C  CG  . TYR A 1 191 ? 19.813  -11.288 2.069   1.00 8.39  ? 191 TYR A CG  1 
ATOM   1563 C  CD1 . TYR A 1 191 ? 18.784  -11.847 1.337   1.00 9.20  ? 191 TYR A CD1 1 
ATOM   1564 C  CD2 . TYR A 1 191 ? 20.023  -11.739 3.365   1.00 9.54  ? 191 TYR A CD2 1 
ATOM   1565 C  CE1 . TYR A 1 191 ? 17.997  -12.848 1.866   1.00 9.79  ? 191 TYR A CE1 1 
ATOM   1566 C  CE2 . TYR A 1 191 ? 19.244  -12.738 3.905   1.00 9.91  ? 191 TYR A CE2 1 
ATOM   1567 C  CZ  . TYR A 1 191 ? 18.238  -13.293 3.152   1.00 10.43 ? 191 TYR A CZ  1 
ATOM   1568 O  OH  . TYR A 1 191 ? 17.476  -14.290 3.716   1.00 14.72 ? 191 TYR A OH  1 
ATOM   1569 N  N   . ARG A 1 192 ? 22.537  -8.674  -0.686  1.00 8.52  ? 192 ARG A N   1 
ATOM   1570 C  CA  . ARG A 1 192 ? 23.294  -7.438  -1.008  1.00 8.30  ? 192 ARG A CA  1 
ATOM   1571 C  C   . ARG A 1 192 ? 22.343  -6.487  -1.728  1.00 8.20  ? 192 ARG A C   1 
ATOM   1572 O  O   . ARG A 1 192 ? 21.599  -6.914  -2.684  1.00 10.05 ? 192 ARG A O   1 
ATOM   1573 C  CB  . ARG A 1 192 ? 24.408  -7.832  -1.995  1.00 9.69  ? 192 ARG A CB  1 
ATOM   1574 C  CG  . ARG A 1 192 ? 25.088  -6.692  -2.790  1.00 11.02 ? 192 ARG A CG  1 
ATOM   1575 C  CD  . ARG A 1 192 ? 25.875  -5.707  -1.908  1.00 12.49 ? 192 ARG A CD  1 
ATOM   1576 N  NE  . ARG A 1 192 ? 26.858  -6.415  -1.076  1.00 12.37 ? 192 ARG A NE  1 
ATOM   1577 C  CZ  . ARG A 1 192 ? 27.981  -6.985  -1.520  1.00 11.32 ? 192 ARG A CZ  1 
ATOM   1578 N  NH1 . ARG A 1 192 ? 28.295  -6.955  -2.809  1.00 15.34 ? 192 ARG A NH1 1 
ATOM   1579 N  NH2 . ARG A 1 192 ? 28.796  -7.605  -0.669  1.00 12.82 ? 192 ARG A NH2 1 
ATOM   1580 N  N   . TYR A 1 193 ? 22.364  -5.224  -1.342  1.00 7.70  ? 193 TYR A N   1 
ATOM   1581 C  CA  . TYR A 1 193 ? 21.546  -4.273  -2.113  1.00 7.09  ? 193 TYR A CA  1 
ATOM   1582 C  C   . TYR A 1 193 ? 22.112  -2.901  -1.819  1.00 7.35  ? 193 TYR A C   1 
ATOM   1583 O  O   . TYR A 1 193 ? 22.826  -2.667  -0.802  1.00 8.44  ? 193 TYR A O   1 
ATOM   1584 C  CB  . TYR A 1 193 ? 20.062  -4.342  -1.724  1.00 7.31  ? 193 TYR A CB  1 
ATOM   1585 C  CG  . TYR A 1 193 ? 19.643  -3.810  -0.351  1.00 7.24  ? 193 TYR A CG  1 
ATOM   1586 C  CD1 . TYR A 1 193 ? 19.113  -2.528  -0.223  1.00 7.79  ? 193 TYR A CD1 1 
ATOM   1587 C  CD2 . TYR A 1 193 ? 19.838  -4.539  0.811   1.00 7.14  ? 193 TYR A CD2 1 
ATOM   1588 C  CE1 . TYR A 1 193 ? 18.809  -1.956  1.003   1.00 7.70  ? 193 TYR A CE1 1 
ATOM   1589 C  CE2 . TYR A 1 193 ? 19.521  -4.071  2.062   1.00 7.20  ? 193 TYR A CE2 1 
ATOM   1590 C  CZ  . TYR A 1 193 ? 18.987  -2.781  2.139   1.00 6.55  ? 193 TYR A CZ  1 
ATOM   1591 O  OH  . TYR A 1 193 ? 18.683  -2.172  3.300   1.00 6.68  ? 193 TYR A OH  1 
ATOM   1592 N  N   . ARG A 1 194 ? 21.742  -1.971  -2.649  1.00 8.64  ? 194 ARG A N   1 
ATOM   1593 C  CA  . ARG A 1 194 ? 22.152  -0.593  -2.423  1.00 8.59  ? 194 ARG A CA  1 
ATOM   1594 C  C   . ARG A 1 194 ? 21.117  0.164   -1.659  1.00 8.98  ? 194 ARG A C   1 
ATOM   1595 O  O   . ARG A 1 194 ? 19.908  0.180   -1.981  1.00 9.59  ? 194 ARG A O   1 
ATOM   1596 C  CB  . ARG A 1 194 ? 22.255  0.163   -3.819  1.00 13.54 ? 194 ARG A CB  1 
ATOM   1597 C  CG  . ARG A 1 194 ? 23.523  -0.293  -4.501  1.00 16.78 ? 194 ARG A CG  1 
ATOM   1598 C  CD  . ARG A 1 194 ? 23.934  0.571   -5.751  1.00 29.21 ? 194 ARG A CD  1 
ATOM   1599 N  NE  . ARG A 1 194 ? 25.207  0.002   -6.269  1.00 38.71 ? 194 ARG A NE  1 
ATOM   1600 C  CZ  . ARG A 1 194 ? 26.444  0.299   -5.824  1.00 46.89 ? 194 ARG A CZ  1 
ATOM   1601 N  NH1 . ARG A 1 194 ? 26.656  1.231   -4.877  1.00 43.04 ? 194 ARG A NH1 1 
ATOM   1602 N  NH2 . ARG A 1 194 ? 27.493  -0.337  -6.351  1.00 50.97 ? 194 ARG A NH2 1 
ATOM   1603 N  N   . GLY A 1 195 ? 21.515  0.770   -0.546  1.00 7.74  ? 195 GLY A N   1 
ATOM   1604 C  CA  . GLY A 1 195 ? 20.576  1.462   0.290   1.00 8.12  ? 195 GLY A CA  1 
ATOM   1605 C  C   . GLY A 1 195 ? 21.111  2.660   1.025   1.00 7.01  ? 195 GLY A C   1 
ATOM   1606 O  O   . GLY A 1 195 ? 21.933  3.427   0.454   1.00 8.16  ? 195 GLY A O   1 
ATOM   1607 N  N   . SER A 1 196 ? 20.674  2.875   2.252   1.00 6.08  ? 196 SER A N   1 
ATOM   1608 C  CA  . SER A 1 196 ? 20.977  4.122   2.915   1.00 6.62  ? 196 SER A CA  1 
ATOM   1609 C  C   . SER A 1 196 ? 21.383  3.857   4.364   1.00 6.63  ? 196 SER A C   1 
ATOM   1610 O  O   . SER A 1 196 ? 21.220  2.730   4.915   1.00 6.12  ? 196 SER A O   1 
ATOM   1611 C  CB  . SER A 1 196 ? 19.757  5.062   3.024   1.00 7.31  ? 196 SER A CB  1 
ATOM   1612 O  OG  . SER A 1 196 ? 18.797  4.557   3.971   1.00 6.35  ? 196 SER A OG  1 
ATOM   1613 N  N   . LEU A 1 197 ? 21.915  4.860   5.005   1.00 7.04  ? 197 LEU A N   1 
ATOM   1614 C  CA  . LEU A 1 197 ? 21.969  4.876   6.441   1.00 7.60  ? 197 LEU A CA  1 
ATOM   1615 C  C   . LEU A 1 197 ? 20.565  4.647   7.010   1.00 6.81  ? 197 LEU A C   1 
ATOM   1616 O  O   . LEU A 1 197 ? 19.576  5.228   6.455   1.00 7.02  ? 197 LEU A O   1 
ATOM   1617 C  CB  . LEU A 1 197 ? 22.578  6.188   7.047   1.00 8.88  ? 197 LEU A CB  1 
ATOM   1618 C  CG  . LEU A 1 197 ? 24.008  6.416   6.575   1.00 10.96 ? 197 LEU A CG  1 
ATOM   1619 C  CD1 . LEU A 1 197 ? 24.323  7.794   7.133   1.00 12.12 ? 197 LEU A CD1 1 
ATOM   1620 C  CD2 . LEU A 1 197 ? 24.921  5.409   7.136   1.00 12.26 ? 197 LEU A CD2 1 
ATOM   1621 N  N   . THR A 1 198 ? 20.444  3.969   8.161   1.00 6.43  ? 198 THR A N   1 
ATOM   1622 C  CA  . THR A 1 198 ? 19.137  3.797   8.779   1.00 6.33  ? 198 THR A CA  1 
ATOM   1623 C  C   . THR A 1 198 ? 18.831  4.803   9.864   1.00 7.69  ? 198 THR A C   1 
ATOM   1624 O  O   . THR A 1 198 ? 17.800  4.724   10.541  1.00 8.49  ? 198 THR A O   1 
ATOM   1625 C  CB  . THR A 1 198 ? 18.917  2.370   9.335   1.00 7.11  ? 198 THR A CB  1 
ATOM   1626 O  OG1 . THR A 1 198 ? 19.856  2.187   10.430  1.00 7.67  ? 198 THR A OG1 1 
ATOM   1627 C  CG2 . THR A 1 198 ? 19.072  1.303   8.274   1.00 6.62  ? 198 THR A CG2 1 
ATOM   1628 N  N   . THR A 1 199 ? 19.767  5.761   10.084  1.00 8.00  ? 199 THR A N   1 
ATOM   1629 C  CA  . THR A 1 199 ? 19.585  6.873   10.955  1.00 8.12  ? 199 THR A CA  1 
ATOM   1630 C  C   . THR A 1 199 ? 19.895  8.141   10.167  1.00 7.43  ? 199 THR A C   1 
ATOM   1631 O  O   . THR A 1 199 ? 20.568  8.055   9.169   1.00 7.86  ? 199 THR A O   1 
ATOM   1632 C  CB  . THR A 1 199 ? 20.563  6.912   12.150  1.00 9.38  ? 199 THR A CB  1 
ATOM   1633 O  OG1 . THR A 1 199 ? 21.937  6.910   11.673  1.00 12.39 ? 199 THR A OG1 1 
ATOM   1634 C  CG2 . THR A 1 199 ? 20.336  5.622   12.992  1.00 11.09 ? 199 THR A CG2 1 
ATOM   1635 N  N   . PRO A 1 200 ? 19.400  9.259   10.714  1.00 8.07  ? 200 PRO A N   1 
ATOM   1636 C  CA  . PRO A 1 200 ? 19.844  10.507  10.124  1.00 8.85  ? 200 PRO A CA  1 
ATOM   1637 C  C   . PRO A 1 200 ? 21.383  10.573  9.988   1.00 9.54  ? 200 PRO A C   1 
ATOM   1638 O  O   . PRO A 1 200 ? 22.048  10.092  10.911  1.00 9.76  ? 200 PRO A O   1 
ATOM   1639 C  CB  . PRO A 1 200 ? 19.323  11.525  11.091  1.00 8.24  ? 200 PRO A CB  1 
ATOM   1640 C  CG  . PRO A 1 200 ? 18.015  10.913  11.683  1.00 8.61  ? 200 PRO A CG  1 
ATOM   1641 C  CD  . PRO A 1 200 ? 18.432  9.431   11.814  1.00 8.17  ? 200 PRO A CD  1 
ATOM   1642 N  N   . PRO A 1 201 ? 21.820  11.149  8.906   1.00 8.80  ? 201 PRO A N   1 
ATOM   1643 C  CA  . PRO A 1 201 ? 21.039  11.874  7.846   1.00 8.42  ? 201 PRO A CA  1 
ATOM   1644 C  C   . PRO A 1 201 ? 20.452  11.020  6.749   1.00 8.04  ? 201 PRO A C   1 
ATOM   1645 O  O   . PRO A 1 201 ? 19.995  11.510  5.701   1.00 8.97  ? 201 PRO A O   1 
ATOM   1646 C  CB  . PRO A 1 201 ? 22.073  12.832  7.182   1.00 9.50  ? 201 PRO A CB  1 
ATOM   1647 C  CG  . PRO A 1 201 ? 23.277  12.764  8.070   1.00 11.09 ? 201 PRO A CG  1 
ATOM   1648 C  CD  . PRO A 1 201 ? 23.278  11.367  8.690   1.00 9.53  ? 201 PRO A CD  1 
ATOM   1649 N  N   . CYS A 1 202 ? 20.502  9.676   6.880   1.00 7.35  ? 202 CYS A N   1 
ATOM   1650 C  CA  . CYS A 1 202 ? 19.818  8.695   5.946   1.00 7.15  ? 202 CYS A CA  1 
ATOM   1651 C  C   . CYS A 1 202 ? 20.391  8.777   4.537   1.00 7.52  ? 202 CYS A C   1 
ATOM   1652 O  O   . CYS A 1 202 ? 19.725  8.473   3.554   1.00 7.56  ? 202 CYS A O   1 
ATOM   1653 C  CB  . CYS A 1 202 ? 18.301  8.997   5.877   1.00 8.39  ? 202 CYS A CB  1 
ATOM   1654 S  SG  . CYS A 1 202 ? 17.423  8.912   7.448   1.00 8.90  ? 202 CYS A SG  1 
ATOM   1655 N  N   . ASN A 1 203 ? 21.660  9.157   4.410   1.00 8.35  ? 203 ASN A N   1 
ATOM   1656 C  CA  . ASN A 1 203 ? 22.218  9.273   3.079   1.00 9.48  ? 203 ASN A CA  1 
ATOM   1657 C  C   . ASN A 1 203 ? 22.174  8.007   2.303   1.00 8.45  ? 203 ASN A C   1 
ATOM   1658 O  O   . ASN A 1 203 ? 22.465  6.908   2.860   1.00 6.39  ? 203 ASN A O   1 
ATOM   1659 C  CB  . ASN A 1 203 ? 23.666  9.691   3.157   1.00 12.11 ? 203 ASN A CB  1 
ATOM   1660 C  CG  . ASN A 1 203 ? 23.872  10.880  4.037   1.00 13.56 ? 203 ASN A CG  1 
ATOM   1661 O  OD1 . ASN A 1 203 ? 24.014  10.758  5.230   1.00 15.10 ? 203 ASN A OD1 1 
ATOM   1662 N  ND2 . ASN A 1 203 ? 23.852  12.070  3.451   1.00 15.83 ? 203 ASN A ND2 1 
ATOM   1663 N  N   . PRO A 1 204 ? 21.801  8.017   1.043   1.00 8.35  ? 204 PRO A N   1 
ATOM   1664 C  CA  . PRO A 1 204 ? 21.651  6.777   0.220   1.00 8.42  ? 204 PRO A CA  1 
ATOM   1665 C  C   . PRO A 1 204 ? 22.962  6.328   -0.387  1.00 9.04  ? 204 PRO A C   1 
ATOM   1666 O  O   . PRO A 1 204 ? 23.106  6.168   -1.618  1.00 12.11 ? 204 PRO A O   1 
ATOM   1667 C  CB  . PRO A 1 204 ? 20.649  7.224   -0.891  1.00 8.88  ? 204 PRO A CB  1 
ATOM   1668 C  CG  . PRO A 1 204 ? 21.026  8.732   -1.044  1.00 9.48  ? 204 PRO A CG  1 
ATOM   1669 C  CD  . PRO A 1 204 ? 21.250  9.272   0.359   1.00 9.00  ? 204 PRO A CD  1 
ATOM   1670 N  N   . THR A 1 205 ? 23.897  6.088   0.533   1.00 8.92  ? 205 THR A N   1 
ATOM   1671 C  CA  . THR A 1 205 ? 25.304  5.866   0.101   1.00 9.88  ? 205 THR A CA  1 
ATOM   1672 C  C   . THR A 1 205 ? 25.864  4.583   0.682   1.00 9.63  ? 205 THR A C   1 
ATOM   1673 O  O   . THR A 1 205 ? 27.073  4.388   0.594   1.00 10.07 ? 205 THR A O   1 
ATOM   1674 C  CB  . THR A 1 205 ? 26.160  6.959   0.693   1.00 9.98  ? 205 THR A CB  1 
ATOM   1675 O  OG1 . THR A 1 205 ? 25.944  7.043   2.061   1.00 10.27 ? 205 THR A OG1 1 
ATOM   1676 C  CG2 . THR A 1 205 ? 25.801  8.382   0.006   1.00 13.86 ? 205 THR A CG2 1 
ATOM   1677 N  N   . VAL A 1 206 ? 24.966  3.618   1.048   1.00 8.62  ? 206 VAL A N   1 
ATOM   1678 C  CA  . VAL A 1 206 ? 25.431  2.366   1.687   1.00 9.04  ? 206 VAL A CA  1 
ATOM   1679 C  C   . VAL A 1 206 ? 25.235  1.197   0.797   1.00 8.78  ? 206 VAL A C   1 
ATOM   1680 O  O   . VAL A 1 206 ? 24.120  0.915   0.327   1.00 9.95  ? 206 VAL A O   1 
ATOM   1681 C  CB  . VAL A 1 206 ? 24.630  2.185   2.992   1.00 7.72  ? 206 VAL A CB  1 
ATOM   1682 C  CG1 . VAL A 1 206 ? 25.074  0.908   3.661   1.00 7.22  ? 206 VAL A CG1 1 
ATOM   1683 C  CG2 . VAL A 1 206 ? 24.929  3.324   3.986   1.00 8.09  ? 206 VAL A CG2 1 
ATOM   1684 N  N   . LEU A 1 207 ? 26.300  0.415   0.580   1.00 7.35  ? 207 LEU A N   1 
ATOM   1685 C  CA  . LEU A 1 207 ? 26.230  -0.905  0.016   1.00 8.81  ? 207 LEU A CA  1 
ATOM   1686 C  C   . LEU A 1 207 ? 25.997  -1.874  1.196   1.00 7.30  ? 207 LEU A C   1 
ATOM   1687 O  O   . LEU A 1 207 ? 26.848  -1.971  2.079   1.00 7.64  ? 207 LEU A O   1 
ATOM   1688 C  CB  . LEU A 1 207 ? 27.508  -1.204  -0.753  1.00 11.21 ? 207 LEU A CB  1 
ATOM   1689 C  CG  . LEU A 1 207 ? 27.349  -2.512  -1.555  1.00 13.82 ? 207 LEU A CG  1 
ATOM   1690 C  CD1 . LEU A 1 207 ? 26.234  -2.441  -2.636  1.00 16.95 ? 207 LEU A CD1 1 
ATOM   1691 C  CD2 . LEU A 1 207 ? 28.673  -3.022  -2.103  1.00 17.21 ? 207 LEU A CD2 1 
ATOM   1692 N  N   . TRP A 1 208 ? 24.800  -2.444  1.271   1.00 6.94  ? 208 TRP A N   1 
ATOM   1693 C  CA  . TRP A 1 208 ? 24.443  -3.356  2.379   1.00 6.45  ? 208 TRP A CA  1 
ATOM   1694 C  C   . TRP A 1 208 ? 24.794  -4.755  2.083   1.00 6.76  ? 208 TRP A C   1 
ATOM   1695 O  O   . TRP A 1 208 ? 24.534  -5.246  0.978   1.00 7.14  ? 208 TRP A O   1 
ATOM   1696 C  CB  . TRP A 1 208 ? 22.896  -3.295  2.619   1.00 6.28  ? 208 TRP A CB  1 
ATOM   1697 C  CG  . TRP A 1 208 ? 22.563  -2.116  3.441   1.00 6.30  ? 208 TRP A CG  1 
ATOM   1698 C  CD1 . TRP A 1 208 ? 22.099  -0.853  2.971   1.00 5.31  ? 208 TRP A CD1 1 
ATOM   1699 C  CD2 . TRP A 1 208 ? 22.652  -1.956  4.844   1.00 5.97  ? 208 TRP A CD2 1 
ATOM   1700 N  NE1 . TRP A 1 208 ? 21.899  0.003   3.969   1.00 5.93  ? 208 TRP A NE1 1 
ATOM   1701 C  CE2 . TRP A 1 208 ? 22.263  -0.595  5.197   1.00 5.80  ? 208 TRP A CE2 1 
ATOM   1702 C  CE3 . TRP A 1 208 ? 23.053  -2.787  5.875   1.00 6.00  ? 208 TRP A CE3 1 
ATOM   1703 C  CZ2 . TRP A 1 208 ? 22.268  -0.121  6.528   1.00 6.36  ? 208 TRP A CZ2 1 
ATOM   1704 C  CZ3 . TRP A 1 208 ? 23.036  -2.335  7.166   1.00 6.28  ? 208 TRP A CZ3 1 
ATOM   1705 C  CH2 . TRP A 1 208 ? 22.657  -1.025  7.506   1.00 6.95  ? 208 TRP A CH2 1 
ATOM   1706 N  N   . THR A 1 209 ? 25.371  -5.475  3.063   1.00 5.75  ? 209 THR A N   1 
ATOM   1707 C  CA  . THR A 1 209 ? 25.618  -6.915  2.983   1.00 7.27  ? 209 THR A CA  1 
ATOM   1708 C  C   . THR A 1 209 ? 24.943  -7.461  4.248   1.00 6.50  ? 209 THR A C   1 
ATOM   1709 O  O   . THR A 1 209 ? 25.422  -7.087  5.377   1.00 7.32  ? 209 THR A O   1 
ATOM   1710 C  CB  . THR A 1 209 ? 27.080  -7.267  3.020   1.00 6.51  ? 209 THR A CB  1 
ATOM   1711 O  OG1 . THR A 1 209 ? 27.616  -6.677  1.798   1.00 8.57  ? 209 THR A OG1 1 
ATOM   1712 C  CG2 . THR A 1 209 ? 27.263  -8.781  2.941   1.00 7.73  ? 209 THR A CG2 1 
ATOM   1713 N  N   . VAL A 1 210 ? 23.831  -8.198  4.097   1.00 6.40  ? 210 VAL A N   1 
ATOM   1714 C  CA  . VAL A 1 210 ? 23.192  -8.752  5.310   1.00 6.37  ? 210 VAL A CA  1 
ATOM   1715 C  C   . VAL A 1 210 ? 23.442  -10.254 5.256   1.00 6.53  ? 210 VAL A C   1 
ATOM   1716 O  O   . VAL A 1 210 ? 23.087  -10.874 4.274   1.00 7.00  ? 210 VAL A O   1 
ATOM   1717 C  CB  . VAL A 1 210 ? 21.677  -8.441  5.243   1.00 7.06  ? 210 VAL A CB  1 
ATOM   1718 C  CG1 . VAL A 1 210 ? 21.043  -9.084  6.500   1.00 8.04  ? 210 VAL A CG1 1 
ATOM   1719 C  CG2 . VAL A 1 210 ? 21.367  -6.939  5.151   1.00 8.15  ? 210 VAL A CG2 1 
ATOM   1720 N  N   . PHE A 1 211 ? 24.140  -10.817 6.220   1.00 6.46  ? 211 PHE A N   1 
ATOM   1721 C  CA  . PHE A 1 211 ? 24.414  -12.273 6.187   1.00 7.13  ? 211 PHE A CA  1 
ATOM   1722 C  C   . PHE A 1 211 ? 23.146  -13.047 6.268   1.00 7.19  ? 211 PHE A C   1 
ATOM   1723 O  O   . PHE A 1 211 ? 22.218  -12.719 7.027   1.00 7.53  ? 211 PHE A O   1 
ATOM   1724 C  CB  . PHE A 1 211 ? 25.424  -12.569 7.264   1.00 7.75  ? 211 PHE A CB  1 
ATOM   1725 C  CG  . PHE A 1 211 ? 26.750  -11.939 6.981   1.00 7.53  ? 211 PHE A CG  1 
ATOM   1726 C  CD1 . PHE A 1 211 ? 27.564  -12.391 5.887   1.00 7.71  ? 211 PHE A CD1 1 
ATOM   1727 C  CD2 . PHE A 1 211 ? 27.216  -10.844 7.742   1.00 8.46  ? 211 PHE A CD2 1 
ATOM   1728 C  CE1 . PHE A 1 211 ? 28.774  -11.745 5.566   1.00 9.10  ? 211 PHE A CE1 1 
ATOM   1729 C  CE2 . PHE A 1 211 ? 28.467  -10.284 7.429   1.00 8.51  ? 211 PHE A CE2 1 
ATOM   1730 C  CZ  . PHE A 1 211 ? 29.222  -10.693 6.345   1.00 9.68  ? 211 PHE A CZ  1 
ATOM   1731 N  N   . ARG A 1 212 ? 23.130  -14.157 5.511   1.00 8.30  ? 212 ARG A N   1 
ATOM   1732 C  CA  . ARG A 1 212 ? 21.918  -14.987 5.511   1.00 8.44  ? 212 ARG A CA  1 
ATOM   1733 C  C   . ARG A 1 212 ? 21.628  -15.628 6.876   1.00 8.66  ? 212 ARG A C   1 
ATOM   1734 O  O   . ARG A 1 212 ? 20.452  -15.673 7.292   1.00 10.24 ? 212 ARG A O   1 
ATOM   1735 C  CB  . ARG A 1 212 ? 22.098  -16.118 4.529   1.00 10.05 ? 212 ARG A CB  1 
ATOM   1736 C  CG  . ARG A 1 212 ? 20.837  -16.934 4.301   1.00 12.20 ? 212 ARG A CG  1 
ATOM   1737 C  CD  . ARG A 1 212 ? 21.241  -18.206 3.612   1.00 14.40 ? 212 ARG A CD  1 
ATOM   1738 N  NE  . ARG A 1 212 ? 19.992  -18.894 3.225   1.00 21.01 ? 212 ARG A NE  1 
ATOM   1739 C  CZ  . ARG A 1 212 ? 19.915  -19.831 2.261   1.00 23.23 ? 212 ARG A CZ  1 
ATOM   1740 N  NH1 . ARG A 1 212 ? 21.002  -20.282 1.671   1.00 24.55 ? 212 ARG A NH1 1 
ATOM   1741 N  NH2 . ARG A 1 212 ? 18.710  -20.329 1.934   1.00 26.31 ? 212 ARG A NH2 1 
ATOM   1742 N  N   . ASN A 1 213 ? 22.672  -16.060 7.587   1.00 8.25  ? 213 ASN A N   1 
ATOM   1743 C  CA  . ASN A 1 213 ? 22.457  -16.865 8.829   1.00 9.80  ? 213 ASN A CA  1 
ATOM   1744 C  C   . ASN A 1 213 ? 22.589  -15.934 10.029  1.00 9.10  ? 213 ASN A C   1 
ATOM   1745 O  O   . ASN A 1 213 ? 23.490  -15.165 10.077  1.00 8.87  ? 213 ASN A O   1 
ATOM   1746 C  CB  . ASN A 1 213 ? 23.564  -17.950 8.847   1.00 10.43 ? 213 ASN A CB  1 
ATOM   1747 C  CG  . ASN A 1 213 ? 23.425  -18.862 7.651   1.00 13.63 ? 213 ASN A CG  1 
ATOM   1748 O  OD1 . ASN A 1 213 ? 22.300  -19.214 7.245   1.00 17.69 ? 213 ASN A OD1 1 
ATOM   1749 N  ND2 . ASN A 1 213 ? 24.528  -19.058 6.969   1.00 12.46 ? 213 ASN A ND2 1 
ATOM   1750 N  N   . PRO A 1 214 ? 21.708  -16.046 11.022  1.00 8.91  ? 214 PRO A N   1 
ATOM   1751 C  CA  . PRO A 1 214 ? 21.835  -15.309 12.252  1.00 9.12  ? 214 PRO A CA  1 
ATOM   1752 C  C   . PRO A 1 214 ? 22.892  -15.887 13.190  1.00 9.68  ? 214 PRO A C   1 
ATOM   1753 O  O   . PRO A 1 214 ? 23.289  -17.074 13.081  1.00 11.43 ? 214 PRO A O   1 
ATOM   1754 C  CB  . PRO A 1 214 ? 20.422  -15.480 12.928  1.00 9.90  ? 214 PRO A CB  1 
ATOM   1755 C  CG  . PRO A 1 214 ? 19.998  -16.816 12.437  1.00 11.89 ? 214 PRO A CG  1 
ATOM   1756 C  CD  . PRO A 1 214 ? 20.521  -16.932 10.992  1.00 10.67 ? 214 PRO A CD  1 
ATOM   1757 N  N   . VAL A 1 215 ? 23.266  -15.061 14.147  1.00 8.65  ? 215 VAL A N   1 
ATOM   1758 C  CA  . VAL A 1 215 ? 24.031  -15.569 15.296  1.00 9.19  ? 215 VAL A CA  1 
ATOM   1759 C  C   . VAL A 1 215 ? 23.052  -15.720 16.447  1.00 9.42  ? 215 VAL A C   1 
ATOM   1760 O  O   . VAL A 1 215 ? 21.978  -15.157 16.409  1.00 10.23 ? 215 VAL A O   1 
ATOM   1761 C  CB  . VAL A 1 215 ? 25.197  -14.651 15.690  1.00 9.56  ? 215 VAL A CB  1 
ATOM   1762 C  CG1 . VAL A 1 215 ? 26.218  -14.540 14.519  1.00 11.32 ? 215 VAL A CG1 1 
ATOM   1763 C  CG2 . VAL A 1 215 ? 24.710  -13.293 16.139  1.00 10.46 ? 215 VAL A CG2 1 
ATOM   1764 N  N   . GLN A 1 216 ? 23.463  -16.445 17.474  1.00 10.16 ? 216 GLN A N   1 
ATOM   1765 C  CA  . GLN A 1 216 ? 22.696  -16.537 18.738  1.00 10.98 ? 216 GLN A CA  1 
ATOM   1766 C  C   . GLN A 1 216 ? 23.369  -15.960 19.876  1.00 10.65 ? 216 GLN A C   1 
ATOM   1767 O  O   . GLN A 1 216 ? 24.601  -16.010 20.012  1.00 11.21 ? 216 GLN A O   1 
ATOM   1768 C  CB  . GLN A 1 216 ? 22.427  -17.984 19.116  1.00 11.83 ? 216 GLN A CB  1 
ATOM   1769 C  CG  . GLN A 1 216 ? 21.689  -18.716 18.059  1.00 13.29 ? 216 GLN A CG  1 
ATOM   1770 C  CD  . GLN A 1 216 ? 21.365  -20.160 18.470  1.00 21.18 ? 216 GLN A CD  1 
ATOM   1771 O  OE1 . GLN A 1 216 ? 21.708  -20.657 19.603  1.00 27.89 ? 216 GLN A OE1 1 
ATOM   1772 N  NE2 . GLN A 1 216 ? 20.750  -20.875 17.536  1.00 28.07 ? 216 GLN A NE2 1 
ATOM   1773 N  N   . ILE A 1 217 ? 22.588  -15.304 20.759  1.00 10.23 ? 217 ILE A N   1 
ATOM   1774 C  CA  . ILE A 1 217 ? 23.075  -14.827 22.074  1.00 11.02 ? 217 ILE A CA  1 
ATOM   1775 C  C   . ILE A 1 217 ? 22.073  -15.333 23.111  1.00 10.60 ? 217 ILE A C   1 
ATOM   1776 O  O   . ILE A 1 217 ? 20.960  -15.633 22.750  1.00 9.95  ? 217 ILE A O   1 
ATOM   1777 C  CB  . ILE A 1 217 ? 23.215  -13.307 22.080  1.00 9.98  ? 217 ILE A CB  1 
ATOM   1778 C  CG1 . ILE A 1 217 ? 21.828  -12.583 21.975  1.00 10.90 ? 217 ILE A CG1 1 
ATOM   1779 C  CG2 . ILE A 1 217 ? 24.187  -12.895 20.959  1.00 10.75 ? 217 ILE A CG2 1 
ATOM   1780 C  CD1 . ILE A 1 217 ? 21.946  -11.111 22.199  1.00 11.46 ? 217 ILE A CD1 1 
ATOM   1781 N  N   . SER A 1 218 ? 22.459  -15.363 24.379  1.00 10.74 ? 218 SER A N   1 
ATOM   1782 C  CA  . SER A 1 218 ? 21.486  -16.001 25.292  1.00 11.65 ? 218 SER A CA  1 
ATOM   1783 C  C   . SER A 1 218 ? 20.378  -15.023 25.673  1.00 12.51 ? 218 SER A C   1 
ATOM   1784 O  O   . SER A 1 218 ? 20.459  -13.756 25.480  1.00 11.14 ? 218 SER A O   1 
ATOM   1785 C  CB  . SER A 1 218 ? 22.191  -16.367 26.593  1.00 11.85 ? 218 SER A CB  1 
ATOM   1786 O  OG  . SER A 1 218 ? 22.720  -15.239 27.296  1.00 11.45 ? 218 SER A OG  1 
ATOM   1787 N  N   A GLN A 1 219 ? 19.344  -15.573 26.313  0.50 13.38 ? 219 GLN A N   1 
ATOM   1788 N  N   B GLN A 1 219 ? 19.345  -15.638 26.281  0.50 12.08 ? 219 GLN A N   1 
ATOM   1789 C  CA  A GLN A 1 219 ? 18.303  -14.678 26.827  0.50 13.92 ? 219 GLN A CA  1 
ATOM   1790 C  CA  B GLN A 1 219 ? 18.271  -14.892 26.950  0.50 12.14 ? 219 GLN A CA  1 
ATOM   1791 C  C   A GLN A 1 219 ? 18.834  -13.622 27.807  0.50 12.55 ? 219 GLN A C   1 
ATOM   1792 C  C   B GLN A 1 219 ? 18.788  -13.742 27.784  0.50 11.34 ? 219 GLN A C   1 
ATOM   1793 O  O   A GLN A 1 219 ? 18.421  -12.460 27.792  0.50 11.48 ? 219 GLN A O   1 
ATOM   1794 O  O   B GLN A 1 219 ? 18.262  -12.651 27.649  0.50 10.48 ? 219 GLN A O   1 
ATOM   1795 C  CB  A GLN A 1 219 ? 17.162  -15.494 27.432  0.50 18.06 ? 219 GLN A CB  1 
ATOM   1796 C  CB  B GLN A 1 219 ? 17.482  -15.853 27.862  0.50 13.07 ? 219 GLN A CB  1 
ATOM   1797 C  CG  A GLN A 1 219 ? 17.314  -15.966 28.888  0.50 20.52 ? 219 GLN A CG  1 
ATOM   1798 C  CG  B GLN A 1 219 ? 16.439  -15.158 28.807  0.50 12.14 ? 219 GLN A CG  1 
ATOM   1799 C  CD  A GLN A 1 219 ? 16.005  -16.622 29.310  0.50 22.14 ? 219 GLN A CD  1 
ATOM   1800 C  CD  B GLN A 1 219 ? 16.960  -14.892 30.208  0.50 12.05 ? 219 GLN A CD  1 
ATOM   1801 O  OE1 A GLN A 1 219 ? 15.531  -17.522 28.610  0.50 24.19 ? 219 GLN A OE1 1 
ATOM   1802 O  OE1 B GLN A 1 219 ? 17.688  -15.790 30.744  0.50 15.00 ? 219 GLN A OE1 1 
ATOM   1803 N  NE2 A GLN A 1 219 ? 15.373  -16.112 30.385  0.50 21.94 ? 219 GLN A NE2 1 
ATOM   1804 N  NE2 B GLN A 1 219 ? 16.726  -13.659 30.784  0.50 8.93  ? 219 GLN A NE2 1 
ATOM   1805 N  N   . GLU A 1 220 ? 19.808  -13.979 28.622  1.00 12.35 ? 220 GLU A N   1 
ATOM   1806 C  CA  . GLU A 1 220 ? 20.332  -13.050 29.524  1.00 12.25 ? 220 GLU A CA  1 
ATOM   1807 C  C   . GLU A 1 220 ? 21.136  -11.940 28.802  1.00 11.79 ? 220 GLU A C   1 
ATOM   1808 O  O   . GLU A 1 220 ? 21.104  -10.761 29.192  1.00 10.94 ? 220 GLU A O   1 
ATOM   1809 C  CB  . GLU A 1 220 ? 21.247  -13.707 30.554  1.00 15.80 ? 220 GLU A CB  1 
ATOM   1810 C  CG  . GLU A 1 220 ? 20.455  -14.714 31.450  1.00 17.67 ? 220 GLU A CG  1 
ATOM   1811 C  CD  . GLU A 1 220 ? 20.268  -16.065 30.795  1.00 25.65 ? 220 GLU A CD  1 
ATOM   1812 O  OE1 . GLU A 1 220 ? 20.883  -16.306 29.733  1.00 23.91 ? 220 GLU A OE1 1 
ATOM   1813 O  OE2 . GLU A 1 220 ? 19.505  -16.886 31.342  1.00 31.44 ? 220 GLU A OE2 1 
ATOM   1814 N  N   . GLN A 1 221 ? 21.871  -12.351 27.719  1.00 11.62 ? 221 GLN A N   1 
ATOM   1815 C  CA  . GLN A 1 221 ? 22.654  -11.348 27.011  1.00 10.36 ? 221 GLN A CA  1 
ATOM   1816 C  C   . GLN A 1 221 ? 21.679  -10.412 26.284  1.00 10.73 ? 221 GLN A C   1 
ATOM   1817 O  O   . GLN A 1 221 ? 21.899  -9.215  26.273  1.00 9.79  ? 221 GLN A O   1 
ATOM   1818 C  CB  . GLN A 1 221 ? 23.506  -12.012 25.935  1.00 11.14 ? 221 GLN A CB  1 
ATOM   1819 C  CG  . GLN A 1 221 ? 24.736  -12.721 26.567  1.00 11.43 ? 221 GLN A CG  1 
ATOM   1820 C  CD  . GLN A 1 221 ? 25.560  -13.368 25.498  1.00 8.99  ? 221 GLN A CD  1 
ATOM   1821 O  OE1 . GLN A 1 221 ? 25.139  -14.295 24.846  1.00 11.25 ? 221 GLN A OE1 1 
ATOM   1822 N  NE2 . GLN A 1 221 ? 26.802  -12.922 25.370  1.00 12.00 ? 221 GLN A NE2 1 
ATOM   1823 N  N   . LEU A 1 222 ? 20.629  -10.962 25.716  1.00 9.89  ? 222 LEU A N   1 
ATOM   1824 C  CA  . LEU A 1 222 ? 19.657  -10.095 25.008  1.00 10.33 ? 222 LEU A CA  1 
ATOM   1825 C  C   . LEU A 1 222 ? 18.987  -9.134  25.948  1.00 9.94  ? 222 LEU A C   1 
ATOM   1826 O  O   . LEU A 1 222 ? 18.823  -7.974  25.691  1.00 9.37  ? 222 LEU A O   1 
ATOM   1827 C  CB  . LEU A 1 222 ? 18.618  -10.928 24.244  1.00 10.38 ? 222 LEU A CB  1 
ATOM   1828 C  CG  . LEU A 1 222 ? 17.518  -10.171 23.543  1.00 10.76 ? 222 LEU A CG  1 
ATOM   1829 C  CD1 . LEU A 1 222 ? 18.143  -9.227  22.456  1.00 10.32 ? 222 LEU A CD1 1 
ATOM   1830 C  CD2 . LEU A 1 222 ? 16.521  -11.198 22.922  1.00 12.37 ? 222 LEU A CD2 1 
ATOM   1831 N  N   . LEU A 1 223 ? 18.584  -9.645  27.143  1.00 10.16 ? 223 LEU A N   1 
ATOM   1832 C  CA  . LEU A 1 223 ? 17.969  -8.757  28.147  1.00 11.20 ? 223 LEU A CA  1 
ATOM   1833 C  C   . LEU A 1 223 ? 18.914  -7.722  28.639  1.00 10.60 ? 223 LEU A C   1 
ATOM   1834 O  O   . LEU A 1 223 ? 18.512  -6.612  28.849  1.00 11.35 ? 223 LEU A O   1 
ATOM   1835 C  CB  . LEU A 1 223 ? 17.542  -9.645  29.322  1.00 12.78 ? 223 LEU A CB  1 
ATOM   1836 C  CG  . LEU A 1 223 ? 16.797  -8.915  30.415  1.00 12.44 ? 223 LEU A CG  1 
ATOM   1837 C  CD1 . LEU A 1 223 ? 15.446  -8.464  29.836  1.00 13.97 ? 223 LEU A CD1 1 
ATOM   1838 C  CD2 . LEU A 1 223 ? 16.654  -9.982  31.506  1.00 14.87 ? 223 LEU A CD2 1 
ATOM   1839 N  N   . ALA A 1 224 ? 20.210  -8.044  28.777  1.00 11.79 ? 224 ALA A N   1 
ATOM   1840 C  CA  . ALA A 1 224 ? 21.169  -7.061  29.181  1.00 13.14 ? 224 ALA A CA  1 
ATOM   1841 C  C   . ALA A 1 224 ? 21.287  -5.949  28.150  1.00 15.02 ? 224 ALA A C   1 
ATOM   1842 O  O   . ALA A 1 224 ? 21.252  -4.771  28.447  1.00 14.54 ? 224 ALA A O   1 
ATOM   1843 C  CB  . ALA A 1 224 ? 22.515  -7.731  29.384  1.00 13.48 ? 224 ALA A CB  1 
ATOM   1844 N  N   . LEU A 1 225 ? 21.369  -6.333  26.884  1.00 11.90 ? 225 LEU A N   1 
ATOM   1845 C  CA  . LEU A 1 225 ? 21.456  -5.300  25.832  1.00 11.66 ? 225 LEU A CA  1 
ATOM   1846 C  C   . LEU A 1 225 ? 20.183  -4.402  25.854  1.00 11.63 ? 225 LEU A C   1 
ATOM   1847 O  O   . LEU A 1 225 ? 20.286  -3.197  25.690  1.00 13.08 ? 225 LEU A O   1 
ATOM   1848 C  CB  . LEU A 1 225 ? 21.516  -6.078  24.534  1.00 10.58 ? 225 LEU A CB  1 
ATOM   1849 C  CG  . LEU A 1 225 ? 21.630  -5.109  23.350  1.00 11.05 ? 225 LEU A CG  1 
ATOM   1850 C  CD1 . LEU A 1 225 ? 22.918  -4.318  23.343  1.00 12.11 ? 225 LEU A CD1 1 
ATOM   1851 C  CD2 . LEU A 1 225 ? 21.584  -5.922  22.053  1.00 11.90 ? 225 LEU A CD2 1 
ATOM   1852 N  N   . GLU A 1 226 ? 19.007  -5.023  26.058  1.00 9.65  ? 226 GLU A N   1 
ATOM   1853 C  CA  . GLU A 1 226 ? 17.769  -4.242  26.076  1.00 12.31 ? 226 GLU A CA  1 
ATOM   1854 C  C   . GLU A 1 226 ? 17.573  -3.375  27.282  1.00 12.89 ? 226 GLU A C   1 
ATOM   1855 O  O   . GLU A 1 226 ? 16.730  -2.507  27.281  1.00 14.04 ? 226 GLU A O   1 
ATOM   1856 C  CB  . GLU A 1 226 ? 16.570  -5.176  25.959  1.00 11.88 ? 226 GLU A CB  1 
ATOM   1857 C  CG  . GLU A 1 226 ? 16.444  -5.897  24.614  1.00 11.58 ? 226 GLU A CG  1 
ATOM   1858 C  CD  . GLU A 1 226 ? 15.573  -7.143  24.702  1.00 12.26 ? 226 GLU A CD  1 
ATOM   1859 O  OE1 . GLU A 1 226 ? 15.296  -7.601  25.832  1.00 11.61 ? 226 GLU A OE1 1 
ATOM   1860 O  OE2 . GLU A 1 226 ? 15.164  -7.666  23.643  1.00 12.37 ? 226 GLU A OE2 1 
ATOM   1861 N  N   . THR A 1 227 ? 18.303  -3.611  28.365  1.00 14.17 ? 227 THR A N   1 
ATOM   1862 C  CA  . THR A 1 227 ? 18.005  -2.939  29.640  1.00 13.17 ? 227 THR A CA  1 
ATOM   1863 C  C   . THR A 1 227 ? 19.203  -2.172  30.133  1.00 13.88 ? 227 THR A C   1 
ATOM   1864 O  O   . THR A 1 227 ? 19.047  -1.430  31.106  1.00 17.40 ? 227 THR A O   1 
ATOM   1865 C  CB  . THR A 1 227 ? 17.548  -3.936  30.769  1.00 13.44 ? 227 THR A CB  1 
ATOM   1866 O  OG1 . THR A 1 227 ? 18.521  -4.924  30.978  1.00 16.03 ? 227 THR A OG1 1 
ATOM   1867 C  CG2 . THR A 1 227 ? 16.275  -4.640  30.406  1.00 15.55 ? 227 THR A CG2 1 
ATOM   1868 N  N   . ALA A 1 228 ? 20.385  -2.309  29.545  1.00 13.72 ? 228 ALA A N   1 
ATOM   1869 C  CA  . ALA A 1 228 ? 21.532  -1.657  30.129  1.00 13.57 ? 228 ALA A CA  1 
ATOM   1870 C  C   . ALA A 1 228 ? 21.676  -0.173  29.888  1.00 14.79 ? 228 ALA A C   1 
ATOM   1871 O  O   . ALA A 1 228 ? 22.401  0.485   30.632  1.00 15.96 ? 228 ALA A O   1 
ATOM   1872 C  CB  . ALA A 1 228 ? 22.805  -2.388  29.678  1.00 15.61 ? 228 ALA A CB  1 
ATOM   1873 N  N   . LEU A 1 229 ? 21.050  0.379   28.828  1.00 11.91 ? 229 LEU A N   1 
ATOM   1874 C  CA  . LEU A 1 229 ? 21.464  1.652   28.329  1.00 12.50 ? 229 LEU A CA  1 
ATOM   1875 C  C   . LEU A 1 229 ? 20.328  2.607   28.329  1.00 12.95 ? 229 LEU A C   1 
ATOM   1876 O  O   . LEU A 1 229 ? 19.157  2.257   28.171  1.00 11.95 ? 229 LEU A O   1 
ATOM   1877 C  CB  . LEU A 1 229 ? 22.026  1.543   26.893  1.00 13.60 ? 229 LEU A CB  1 
ATOM   1878 C  CG  . LEU A 1 229 ? 23.087  0.476   26.691  1.00 14.01 ? 229 LEU A CG  1 
ATOM   1879 C  CD1 . LEU A 1 229 ? 23.432  0.416   25.215  1.00 17.51 ? 229 LEU A CD1 1 
ATOM   1880 C  CD2 . LEU A 1 229 ? 24.295  0.859   27.518  1.00 16.03 ? 229 LEU A CD2 1 
ATOM   1881 N  N   . TYR A 1 230 ? 20.700  3.852   28.481  1.00 12.15 ? 230 TYR A N   1 
ATOM   1882 C  CA  . TYR A 1 230 ? 19.784  5.035   28.378  1.00 13.16 ? 230 TYR A CA  1 
ATOM   1883 C  C   . TYR A 1 230 ? 20.227  5.980   27.290  1.00 13.49 ? 230 TYR A C   1 
ATOM   1884 O  O   . TYR A 1 230 ? 21.407  6.108   26.978  1.00 15.47 ? 230 TYR A O   1 
ATOM   1885 C  CB  . TYR A 1 230 ? 19.827  5.816   29.740  1.00 16.21 ? 230 TYR A CB  1 
ATOM   1886 C  CG  . TYR A 1 230 ? 19.127  5.137   30.881  1.00 22.03 ? 230 TYR A CG  1 
ATOM   1887 C  CD1 . TYR A 1 230 ? 17.904  5.611   31.357  1.00 28.17 ? 230 TYR A CD1 1 
ATOM   1888 C  CD2 . TYR A 1 230 ? 19.721  4.048   31.536  1.00 28.08 ? 230 TYR A CD2 1 
ATOM   1889 C  CE1 . TYR A 1 230 ? 17.251  5.006   32.439  1.00 34.39 ? 230 TYR A CE1 1 
ATOM   1890 C  CE2 . TYR A 1 230 ? 19.076  3.406   32.608  1.00 38.82 ? 230 TYR A CE2 1 
ATOM   1891 C  CZ  . TYR A 1 230 ? 17.835  3.895   33.064  1.00 40.09 ? 230 TYR A CZ  1 
ATOM   1892 O  OH  . TYR A 1 230 ? 17.185  3.296   34.155  1.00 41.93 ? 230 TYR A OH  1 
ATOM   1893 N  N   A CYS A 1 231 ? 19.254  6.731   26.755  0.50 14.11 ? 231 CYS A N   1 
ATOM   1894 N  N   B CYS A 1 231 ? 19.275  6.717   26.706  0.50 16.19 ? 231 CYS A N   1 
ATOM   1895 C  CA  A CYS A 1 231 ? 19.472  7.729   25.756  0.50 14.17 ? 231 CYS A CA  1 
ATOM   1896 C  CA  B CYS A 1 231 ? 19.605  7.712   25.721  0.50 17.71 ? 231 CYS A CA  1 
ATOM   1897 C  C   A CYS A 1 231 ? 19.986  9.005   26.346  0.50 13.44 ? 231 CYS A C   1 
ATOM   1898 C  C   B CYS A 1 231 ? 19.823  9.082   26.316  0.50 15.54 ? 231 CYS A C   1 
ATOM   1899 O  O   A CYS A 1 231 ? 20.686  9.809   25.681  0.50 14.40 ? 231 CYS A O   1 
ATOM   1900 O  O   B CYS A 1 231 ? 20.137  10.068  25.615  0.50 17.25 ? 231 CYS A O   1 
ATOM   1901 C  CB  A CYS A 1 231 ? 18.143  8.070   25.058  0.50 13.62 ? 231 CYS A CB  1 
ATOM   1902 C  CB  B CYS A 1 231 ? 18.532  7.815   24.631  0.50 21.36 ? 231 CYS A CB  1 
ATOM   1903 S  SG  A CYS A 1 231 ? 17.605  6.723   23.973  0.50 14.87 ? 231 CYS A SG  1 
ATOM   1904 S  SG  B CYS A 1 231 ? 16.840  7.302   25.025  0.50 30.56 ? 231 CYS A SG  1 
ATOM   1905 N  N   . THR A 1 232 ? 19.673  9.164   27.629  1.00 14.80 ? 232 THR A N   1 
ATOM   1906 C  CA  . THR A 1 232 ? 19.791  10.451  28.330  1.00 15.64 ? 232 THR A CA  1 
ATOM   1907 C  C   . THR A 1 232 ? 21.090  10.532  29.134  1.00 15.34 ? 232 THR A C   1 
ATOM   1908 O  O   . THR A 1 232 ? 21.734  9.499   29.457  1.00 15.26 ? 232 THR A O   1 
ATOM   1909 C  CB  . THR A 1 232 ? 18.551  10.632  29.217  1.00 13.74 ? 232 THR A CB  1 
ATOM   1910 O  OG1 . THR A 1 232 ? 18.296  9.431   29.933  1.00 15.79 ? 232 THR A OG1 1 
ATOM   1911 C  CG2 . THR A 1 232 ? 17.368  11.059  28.401  1.00 14.77 ? 232 THR A CG2 1 
ATOM   1912 N  N   . HIS A 1 233 ? 21.490  11.767  29.431  1.00 17.30 ? 233 HIS A N   1 
ATOM   1913 C  CA  . HIS A 1 233 ? 22.624  12.002  30.333  1.00 18.86 ? 233 HIS A CA  1 
ATOM   1914 C  C   . HIS A 1 233 ? 22.297  11.533  31.742  1.00 18.73 ? 233 HIS A C   1 
ATOM   1915 O  O   . HIS A 1 233 ? 21.124  11.473  32.161  1.00 16.67 ? 233 HIS A O   1 
ATOM   1916 C  CB  . HIS A 1 233 ? 22.999  13.481  30.370  1.00 21.81 ? 233 HIS A CB  1 
ATOM   1917 C  CG  . HIS A 1 233 ? 23.705  13.956  29.122  1.00 25.98 ? 233 HIS A CG  1 
ATOM   1918 N  ND1 . HIS A 1 233 ? 23.117  14.792  28.225  1.00 35.27 ? 233 HIS A ND1 1 
ATOM   1919 C  CD2 . HIS A 1 233 ? 24.997  13.705  28.643  1.00 27.47 ? 233 HIS A CD2 1 
ATOM   1920 C  CE1 . HIS A 1 233 ? 23.970  15.028  27.195  1.00 28.97 ? 233 HIS A CE1 1 
ATOM   1921 N  NE2 . HIS A 1 233 ? 25.116  14.368  27.446  1.00 28.02 ? 233 HIS A NE2 1 
ATOM   1922 N  N   . MET A 1 234 ? 23.364  11.161  32.442  1.00 17.87 ? 234 MET A N   1 
ATOM   1923 C  CA  . MET A 1 234 ? 23.222  10.677  33.816  1.00 19.27 ? 234 MET A CA  1 
ATOM   1924 C  C   . MET A 1 234 ? 22.376  11.582  34.727  1.00 18.58 ? 234 MET A C   1 
ATOM   1925 O  O   . MET A 1 234 ? 21.575  11.066  35.514  1.00 19.42 ? 234 MET A O   1 
ATOM   1926 C  CB  . MET A 1 234 ? 24.582  10.360  34.411  1.00 19.50 ? 234 MET A CB  1 
ATOM   1927 C  CG  . MET A 1 234 ? 24.501  9.743   35.798  1.00 21.09 ? 234 MET A CG  1 
ATOM   1928 S  SD  . MET A 1 234 ? 26.172  9.365   36.371  1.00 32.04 ? 234 MET A SD  1 
ATOM   1929 C  CE  . MET A 1 234 ? 27.133  10.768  35.828  1.00 31.83 ? 234 MET A CE  1 
ATOM   1930 N  N   . ASP A 1 235 ? 22.553  12.899  34.603  1.00 21.50 ? 235 ASP A N   1 
ATOM   1931 C  CA  . ASP A 1 235 ? 21.885  13.845  35.526  1.00 25.62 ? 235 ASP A CA  1 
ATOM   1932 C  C   . ASP A 1 235 ? 20.553  14.320  35.009  1.00 23.57 ? 235 ASP A C   1 
ATOM   1933 O  O   . ASP A 1 235 ? 19.958  15.251  35.543  1.00 22.74 ? 235 ASP A O   1 
ATOM   1934 C  CB  . ASP A 1 235 ? 22.791  15.041  35.855  1.00 29.60 ? 235 ASP A CB  1 
ATOM   1935 C  CG  . ASP A 1 235 ? 22.940  16.020  34.671  1.00 44.10 ? 235 ASP A CG  1 
ATOM   1936 O  OD1 . ASP A 1 235 ? 22.214  15.879  33.632  1.00 43.56 ? 235 ASP A OD1 1 
ATOM   1937 O  OD2 . ASP A 1 235 ? 23.793  16.938  34.779  1.00 47.62 ? 235 ASP A OD2 1 
ATOM   1938 N  N   . ASP A 1 236 ? 20.051  13.689  33.948  1.00 23.48 ? 236 ASP A N   1 
ATOM   1939 C  CA  . ASP A 1 236 ? 18.774  14.080  33.378  1.00 20.38 ? 236 ASP A CA  1 
ATOM   1940 C  C   . ASP A 1 236 ? 17.645  13.689  34.320  1.00 21.63 ? 236 ASP A C   1 
ATOM   1941 O  O   . ASP A 1 236 ? 17.505  12.508  34.670  1.00 21.94 ? 236 ASP A O   1 
ATOM   1942 C  CB  . ASP A 1 236 ? 18.541  13.395  32.017  1.00 21.60 ? 236 ASP A CB  1 
ATOM   1943 C  CG  . ASP A 1 236 ? 17.419  14.036  31.206  1.00 23.37 ? 236 ASP A CG  1 
ATOM   1944 O  OD1 . ASP A 1 236 ? 16.339  14.408  31.728  1.00 25.28 ? 236 ASP A OD1 1 
ATOM   1945 O  OD2 . ASP A 1 236 ? 17.640  14.209  29.987  1.00 24.21 ? 236 ASP A OD2 1 
ATOM   1946 N  N   . PRO A 1 237 ? 16.833  14.677  34.769  1.00 22.45 ? 237 PRO A N   1 
ATOM   1947 C  CA  . PRO A 1 237 ? 15.713  14.311  35.670  1.00 24.16 ? 237 PRO A CA  1 
ATOM   1948 C  C   . PRO A 1 237 ? 14.575  13.466  35.027  1.00 25.41 ? 237 PRO A C   1 
ATOM   1949 O  O   . PRO A 1 237 ? 13.707  12.945  35.750  1.00 24.81 ? 237 PRO A O   1 
ATOM   1950 C  CB  . PRO A 1 237 ? 15.187  15.717  36.148  1.00 23.38 ? 237 PRO A CB  1 
ATOM   1951 C  CG  . PRO A 1 237 ? 15.498  16.585  34.949  1.00 23.60 ? 237 PRO A CG  1 
ATOM   1952 C  CD  . PRO A 1 237 ? 16.831  16.117  34.420  1.00 24.71 ? 237 PRO A CD  1 
ATOM   1953 N  N   . SER A 1 238 ? 14.589  13.293  33.686  1.00 23.79 ? 238 SER A N   1 
ATOM   1954 C  CA  . SER A 1 238 ? 13.600  12.455  32.981  1.00 23.04 ? 238 SER A CA  1 
ATOM   1955 C  C   . SER A 1 238 ? 14.353  11.413  32.124  1.00 22.06 ? 238 SER A C   1 
ATOM   1956 O  O   . SER A 1 238 ? 14.452  11.564  30.879  1.00 20.62 ? 238 SER A O   1 
ATOM   1957 C  CB  . SER A 1 238 ? 12.739  13.296  32.042  1.00 26.25 ? 238 SER A CB  1 
ATOM   1958 O  OG  . SER A 1 238 ? 12.015  14.276  32.784  1.00 33.36 ? 238 SER A OG  1 
ATOM   1959 N  N   . PRO A 1 239 ? 14.898  10.399  32.775  1.00 21.26 ? 239 PRO A N   1 
ATOM   1960 C  CA  . PRO A 1 239 ? 15.669  9.384   32.003  1.00 20.82 ? 239 PRO A CA  1 
ATOM   1961 C  C   . PRO A 1 239 ? 14.790  8.654   30.962  1.00 24.10 ? 239 PRO A C   1 
ATOM   1962 O  O   . PRO A 1 239 ? 13.572  8.379   31.193  1.00 23.41 ? 239 PRO A O   1 
ATOM   1963 C  CB  . PRO A 1 239 ? 16.093  8.404   33.094  1.00 20.92 ? 239 PRO A CB  1 
ATOM   1964 C  CG  . PRO A 1 239 ? 15.040  8.587   34.195  1.00 25.57 ? 239 PRO A CG  1 
ATOM   1965 C  CD  . PRO A 1 239 ? 14.844  10.077  34.211  1.00 22.06 ? 239 PRO A CD  1 
ATOM   1966 N  N   . ARG A 1 240 ? 15.402  8.352   29.813  1.00 20.20 ? 240 ARG A N   1 
ATOM   1967 C  CA  . ARG A 1 240 ? 14.747  7.444   28.895  1.00 21.53 ? 240 ARG A CA  1 
ATOM   1968 C  C   . ARG A 1 240 ? 15.615  6.252   28.524  1.00 18.68 ? 240 ARG A C   1 
ATOM   1969 O  O   . ARG A 1 240 ? 16.750  6.397   28.204  1.00 17.58 ? 240 ARG A O   1 
ATOM   1970 C  CB  . ARG A 1 240 ? 14.066  8.086   27.677  1.00 28.62 ? 240 ARG A CB  1 
ATOM   1971 C  CG  . ARG A 1 240 ? 14.849  9.184   26.998  1.00 32.80 ? 240 ARG A CG  1 
ATOM   1972 C  CD  . ARG A 1 240 ? 13.993  10.297  26.332  1.00 35.82 ? 240 ARG A CD  1 
ATOM   1973 N  NE  . ARG A 1 240 ? 14.928  11.367  25.954  1.00 40.88 ? 240 ARG A NE  1 
ATOM   1974 C  CZ  . ARG A 1 240 ? 15.763  11.360  24.896  1.00 38.13 ? 240 ARG A CZ  1 
ATOM   1975 N  NH1 . ARG A 1 240 ? 15.773  10.357  24.018  1.00 35.39 ? 240 ARG A NH1 1 
ATOM   1976 N  NH2 . ARG A 1 240 ? 16.591  12.393  24.704  1.00 38.08 ? 240 ARG A NH2 1 
ATOM   1977 N  N   . GLU A 1 241 ? 15.016  5.095   28.622  1.00 21.05 ? 241 GLU A N   1 
ATOM   1978 C  CA  . GLU A 1 241 ? 15.703  3.870   28.263  1.00 20.94 ? 241 GLU A CA  1 
ATOM   1979 C  C   . GLU A 1 241 ? 16.009  3.852   26.748  1.00 17.75 ? 241 GLU A C   1 
ATOM   1980 O  O   . GLU A 1 241 ? 15.255  4.390   25.901  1.00 18.56 ? 241 GLU A O   1 
ATOM   1981 C  CB  . GLU A 1 241 ? 14.865  2.679   28.625  1.00 24.26 ? 241 GLU A CB  1 
ATOM   1982 C  CG  . GLU A 1 241 ? 14.555  2.495   30.088  1.00 29.62 ? 241 GLU A CG  1 
ATOM   1983 C  CD  . GLU A 1 241 ? 13.382  1.536   30.335  1.00 37.46 ? 241 GLU A CD  1 
ATOM   1984 O  OE1 . GLU A 1 241 ? 12.495  1.359   29.437  1.00 42.54 ? 241 GLU A OE1 1 
ATOM   1985 O  OE2 . GLU A 1 241 ? 13.329  0.952   31.439  1.00 44.09 ? 241 GLU A OE2 1 
ATOM   1986 N  N   . MET A 1 242 ? 17.177  3.293   26.400  1.00 13.56 ? 242 MET A N   1 
ATOM   1987 C  CA  . MET A 1 242 ? 17.507  3.063   25.002  1.00 12.11 ? 242 MET A CA  1 
ATOM   1988 C  C   . MET A 1 242 ? 16.990  1.707   24.635  1.00 11.06 ? 242 MET A C   1 
ATOM   1989 O  O   . MET A 1 242 ? 17.613  0.680   24.842  1.00 11.11 ? 242 MET A O   1 
ATOM   1990 C  CB  . MET A 1 242 ? 19.024  3.206   24.810  1.00 11.28 ? 242 MET A CB  1 
ATOM   1991 C  CG  . MET A 1 242 ? 19.422  3.023   23.334  1.00 12.41 ? 242 MET A CG  1 
ATOM   1992 S  SD  . MET A 1 242 ? 21.194  3.068   23.113  1.00 13.77 ? 242 MET A SD  1 
ATOM   1993 C  CE  . MET A 1 242 ? 21.537  4.762   23.550  1.00 14.36 ? 242 MET A CE  1 
ATOM   1994 N  N   . ILE A 1 243 ? 15.798  1.775   23.994  1.00 10.27 ? 243 ILE A N   1 
ATOM   1995 C  CA  . ILE A 1 243 ? 15.074  0.612   23.553  1.00 9.50  ? 243 ILE A CA  1 
ATOM   1996 C  C   . ILE A 1 243 ? 14.464  0.935   22.158  1.00 8.92  ? 243 ILE A C   1 
ATOM   1997 O  O   . ILE A 1 243 ? 14.318  2.118   21.787  1.00 8.83  ? 243 ILE A O   1 
ATOM   1998 C  CB  . ILE A 1 243 ? 13.936  0.200   24.498  1.00 10.59 ? 243 ILE A CB  1 
ATOM   1999 C  CG1 . ILE A 1 243 ? 13.056  1.396   24.892  1.00 11.47 ? 243 ILE A CG1 1 
ATOM   2000 C  CG2 . ILE A 1 243 ? 14.548  -0.527  25.723  1.00 11.07 ? 243 ILE A CG2 1 
ATOM   2001 C  CD1 . ILE A 1 243 ? 11.755  0.979   25.669  1.00 14.15 ? 243 ILE A CD1 1 
ATOM   2002 N  N   . ASN A 1 244 ? 14.096  -0.111  21.432  1.00 7.47  ? 244 ASN A N   1 
ATOM   2003 C  CA  . ASN A 1 244 ? 13.370  0.024   20.140  1.00 8.30  ? 244 ASN A CA  1 
ATOM   2004 C  C   . ASN A 1 244 ? 14.122  0.983   19.226  1.00 8.34  ? 244 ASN A C   1 
ATOM   2005 O  O   . ASN A 1 244 ? 13.530  1.855   18.551  1.00 7.74  ? 244 ASN A O   1 
ATOM   2006 C  CB  . ASN A 1 244 ? 11.930  0.474   20.436  1.00 8.62  ? 244 ASN A CB  1 
ATOM   2007 C  CG  . ASN A 1 244 ? 11.214  -0.499  21.317  1.00 9.16  ? 244 ASN A CG  1 
ATOM   2008 O  OD1 . ASN A 1 244 ? 11.387  -1.691  21.204  1.00 12.15 ? 244 ASN A OD1 1 
ATOM   2009 N  ND2 . ASN A 1 244 ? 10.442  0.094   22.287  1.00 13.06 ? 244 ASN A ND2 1 
ATOM   2010 N  N   . ASN A 1 245 ? 15.463  0.845   19.188  1.00 6.91  ? 245 ASN A N   1 
ATOM   2011 C  CA  . ASN A 1 245 ? 16.313  1.818   18.418  1.00 7.16  ? 245 ASN A CA  1 
ATOM   2012 C  C   . ASN A 1 245 ? 16.536  1.284   17.047  1.00 6.26  ? 245 ASN A C   1 
ATOM   2013 O  O   . ASN A 1 245 ? 17.699  1.053   16.633  1.00 7.03  ? 245 ASN A O   1 
ATOM   2014 C  CB  . ASN A 1 245 ? 17.614  2.098   19.175  1.00 7.67  ? 245 ASN A CB  1 
ATOM   2015 C  CG  . ASN A 1 245 ? 18.464  0.855   19.410  1.00 7.36  ? 245 ASN A CG  1 
ATOM   2016 O  OD1 . ASN A 1 245 ? 17.987  -0.214  19.535  1.00 8.08  ? 245 ASN A OD1 1 
ATOM   2017 N  ND2 . ASN A 1 245 ? 19.755  1.105   19.631  1.00 10.01 ? 245 ASN A ND2 1 
ATOM   2018 N  N   . PHE A 1 246 ? 15.493  0.997   16.328  1.00 5.67  ? 246 PHE A N   1 
ATOM   2019 C  CA  . PHE A 1 246 ? 15.532  0.486   14.942  1.00 6.52  ? 246 PHE A CA  1 
ATOM   2020 C  C   . PHE A 1 246 ? 14.550  1.324   14.133  1.00 6.00  ? 246 PHE A C   1 
ATOM   2021 O  O   . PHE A 1 246 ? 13.537  1.758   14.692  1.00 6.38  ? 246 PHE A O   1 
ATOM   2022 C  CB  . PHE A 1 246 ? 15.204  -1.042  14.876  1.00 6.54  ? 246 PHE A CB  1 
ATOM   2023 C  CG  . PHE A 1 246 ? 13.835  -1.416  15.373  1.00 7.32  ? 246 PHE A CG  1 
ATOM   2024 C  CD1 . PHE A 1 246 ? 12.750  -1.572  14.464  1.00 7.27  ? 246 PHE A CD1 1 
ATOM   2025 C  CD2 . PHE A 1 246 ? 13.599  -1.609  16.774  1.00 6.76  ? 246 PHE A CD2 1 
ATOM   2026 C  CE1 . PHE A 1 246 ? 11.480  -1.895  14.914  1.00 8.25  ? 246 PHE A CE1 1 
ATOM   2027 C  CE2 . PHE A 1 246 ? 12.335  -1.962  17.206  1.00 8.33  ? 246 PHE A CE2 1 
ATOM   2028 C  CZ  . PHE A 1 246 ? 11.240  -2.003  16.316  1.00 8.15  ? 246 PHE A CZ  1 
ATOM   2029 N  N   . ARG A 1 247 ? 14.839  1.487   12.859  1.00 5.74  ? 247 ARG A N   1 
ATOM   2030 C  CA  . ARG A 1 247 ? 13.886  2.127   11.920  1.00 5.41  ? 247 ARG A CA  1 
ATOM   2031 C  C   . ARG A 1 247 ? 12.915  1.088   11.370  1.00 4.88  ? 247 ARG A C   1 
ATOM   2032 O  O   . ARG A 1 247 ? 13.325  -0.059  11.106  1.00 6.04  ? 247 ARG A O   1 
ATOM   2033 C  CB  . ARG A 1 247 ? 14.692  2.809   10.810  1.00 5.62  ? 247 ARG A CB  1 
ATOM   2034 C  CG  . ARG A 1 247 ? 13.929  3.813   9.988   1.00 5.48  ? 247 ARG A CG  1 
ATOM   2035 C  CD  . ARG A 1 247 ? 14.761  4.221   8.792   1.00 6.06  ? 247 ARG A CD  1 
ATOM   2036 N  NE  . ARG A 1 247 ? 14.113  5.392   8.181   1.00 5.46  ? 247 ARG A NE  1 
ATOM   2037 C  CZ  . ARG A 1 247 ? 14.647  5.984   7.127   1.00 5.83  ? 247 ARG A CZ  1 
ATOM   2038 N  NH1 . ARG A 1 247 ? 15.630  5.429   6.418   1.00 6.38  ? 247 ARG A NH1 1 
ATOM   2039 N  NH2 . ARG A 1 247 ? 14.061  7.070   6.626   1.00 6.32  ? 247 ARG A NH2 1 
ATOM   2040 N  N   . GLN A 1 248 ? 11.658  1.522   11.151  1.00 5.16  ? 248 GLN A N   1 
ATOM   2041 C  CA  . GLN A 1 248 ? 10.725  0.651   10.434  1.00 5.30  ? 248 GLN A CA  1 
ATOM   2042 C  C   . GLN A 1 248 ? 11.178  0.369   9.011   1.00 5.75  ? 248 GLN A C   1 
ATOM   2043 O  O   . GLN A 1 248 ? 11.953  1.170   8.373   1.00 5.73  ? 248 GLN A O   1 
ATOM   2044 C  CB  . GLN A 1 248 ? 9.351   1.334   10.289  1.00 5.38  ? 248 GLN A CB  1 
ATOM   2045 C  CG  . GLN A 1 248 ? 8.698   1.615   11.645  1.00 6.22  ? 248 GLN A CG  1 
ATOM   2046 C  CD  . GLN A 1 248 ? 8.321   0.361   12.430  1.00 6.85  ? 248 GLN A CD  1 
ATOM   2047 O  OE1 . GLN A 1 248 ? 9.110   -0.120  13.261  1.00 8.90  ? 248 GLN A OE1 1 
ATOM   2048 N  NE2 . GLN A 1 248 ? 7.182   -0.279  12.069  1.00 8.20  ? 248 GLN A NE2 1 
ATOM   2049 N  N   . VAL A 1 249 ? 10.825  -0.773  8.441   1.00 6.03  ? 249 VAL A N   1 
ATOM   2050 C  CA  . VAL A 1 249 ? 11.165  -1.074  7.052   1.00 6.45  ? 249 VAL A CA  1 
ATOM   2051 C  C   . VAL A 1 249 ? 10.557  -0.059  6.084   1.00 6.57  ? 249 VAL A C   1 
ATOM   2052 O  O   . VAL A 1 249 ? 9.426   0.436   6.316   1.00 7.12  ? 249 VAL A O   1 
ATOM   2053 C  CB  . VAL A 1 249 ? 10.793  -2.511  6.663   1.00 8.78  ? 249 VAL A CB  1 
ATOM   2054 C  CG1 . VAL A 1 249 ? 11.675  -3.543  7.430   1.00 8.38  ? 249 VAL A CG1 1 
ATOM   2055 C  CG2 . VAL A 1 249 ? 9.318   -2.724  6.847   1.00 9.75  ? 249 VAL A CG2 1 
ATOM   2056 N  N   . GLN A 1 250 ? 11.276  0.170   5.032   1.00 6.26  ? 250 GLN A N   1 
ATOM   2057 C  CA  . GLN A 1 250 ? 10.890  1.137   3.984   1.00 6.67  ? 250 GLN A CA  1 
ATOM   2058 C  C   . GLN A 1 250 ? 10.275  0.416   2.812   1.00 8.08  ? 250 GLN A C   1 
ATOM   2059 O  O   . GLN A 1 250 ? 10.632  -0.720  2.507   1.00 9.28  ? 250 GLN A O   1 
ATOM   2060 C  CB  . GLN A 1 250 ? 12.147  1.862   3.558   1.00 6.55  ? 250 GLN A CB  1 
ATOM   2061 C  CG  . GLN A 1 250 ? 12.934  2.437   4.712   1.00 6.26  ? 250 GLN A CG  1 
ATOM   2062 C  CD  . GLN A 1 250 ? 12.208  3.546   5.407   1.00 6.94  ? 250 GLN A CD  1 
ATOM   2063 O  OE1 . GLN A 1 250 ? 11.963  4.596   4.763   1.00 7.98  ? 250 GLN A OE1 1 
ATOM   2064 N  NE2 . GLN A 1 250 ? 11.859  3.424   6.628   1.00 6.30  ? 250 GLN A NE2 1 
ATOM   2065 N  N   . LYS A 1 251 ? 9.465   1.166   2.067   1.00 8.14  ? 251 LYS A N   1 
ATOM   2066 C  CA  . LYS A 1 251 ? 9.001   0.599   0.778   1.00 9.68  ? 251 LYS A CA  1 
ATOM   2067 C  C   . LYS A 1 251 ? 10.193  0.317   -0.132  1.00 9.56  ? 251 LYS A C   1 
ATOM   2068 O  O   . LYS A 1 251 ? 11.156  1.087   -0.141  1.00 10.30 ? 251 LYS A O   1 
ATOM   2069 C  CB  . LYS A 1 251 ? 8.053   1.563   0.117   1.00 9.81  ? 251 LYS A CB  1 
ATOM   2070 C  CG  . LYS A 1 251 ? 6.654   1.519   0.808   1.00 11.21 ? 251 LYS A CG  1 
ATOM   2071 C  CD  . LYS A 1 251 ? 5.676   2.434   0.192   1.00 11.53 ? 251 LYS A CD  1 
ATOM   2072 C  CE  . LYS A 1 251 ? 4.187   2.144   0.600   1.00 10.17 ? 251 LYS A CE  1 
ATOM   2073 N  NZ  . LYS A 1 251 ? 3.981   2.171   2.085   1.00 8.10  ? 251 LYS A NZ  1 
ATOM   2074 N  N   . PHE A 1 252 ? 10.126  -0.760  -0.913  1.00 10.61 ? 252 PHE A N   1 
ATOM   2075 C  CA  . PHE A 1 252 ? 11.254  -1.131  -1.776  1.00 12.95 ? 252 PHE A CA  1 
ATOM   2076 C  C   . PHE A 1 252 ? 10.544  -1.795  -2.967  1.00 18.17 ? 252 PHE A C   1 
ATOM   2077 O  O   . PHE A 1 252 ? 10.223  -3.005  -2.898  1.00 26.54 ? 252 PHE A O   1 
ATOM   2078 C  CB  . PHE A 1 252 ? 12.016  -2.206  -1.001  1.00 14.58 ? 252 PHE A CB  1 
ATOM   2079 C  CG  . PHE A 1 252 ? 13.256  -2.664  -1.711  1.00 14.75 ? 252 PHE A CG  1 
ATOM   2080 C  CD1 . PHE A 1 252 ? 14.406  -1.905  -1.641  1.00 14.43 ? 252 PHE A CD1 1 
ATOM   2081 C  CD2 . PHE A 1 252 ? 13.309  -3.925  -2.376  1.00 17.34 ? 252 PHE A CD2 1 
ATOM   2082 C  CE1 . PHE A 1 252 ? 15.578  -2.406  -2.284  1.00 14.58 ? 252 PHE A CE1 1 
ATOM   2083 C  CE2 . PHE A 1 252 ? 14.509  -4.387  -2.981  1.00 14.70 ? 252 PHE A CE2 1 
ATOM   2084 C  CZ  . PHE A 1 252 ? 15.638  -3.588  -2.896  1.00 14.67 ? 252 PHE A CZ  1 
ATOM   2085 N  N   . ASP A 1 253 ? 10.286  -1.029  -4.008  1.00 24.69 ? 253 ASP A N   1 
ATOM   2086 C  CA  . ASP A 1 253 ? 9.391   -1.485  -5.136  1.00 23.69 ? 253 ASP A CA  1 
ATOM   2087 C  C   . ASP A 1 253 ? 10.209  -1.457  -6.387  1.00 24.21 ? 253 ASP A C   1 
ATOM   2088 O  O   . ASP A 1 253 ? 11.035  -0.552  -6.579  1.00 24.11 ? 253 ASP A O   1 
ATOM   2089 C  CB  . ASP A 1 253 ? 8.151   -0.557  -5.261  1.00 28.15 ? 253 ASP A CB  1 
ATOM   2090 C  CG  . ASP A 1 253 ? 7.086   -1.040  -6.280  1.00 35.89 ? 253 ASP A CG  1 
ATOM   2091 O  OD1 . ASP A 1 253 ? 6.732   -2.257  -6.326  1.00 34.86 ? 253 ASP A OD1 1 
ATOM   2092 O  OD2 . ASP A 1 253 ? 6.553   -0.155  -7.012  1.00 40.06 ? 253 ASP A OD2 1 
ATOM   2093 N  N   . GLU A 1 254 ? 9.961   -2.447  -7.237  1.00 24.01 ? 254 GLU A N   1 
ATOM   2094 C  CA  . GLU A 1 254 ? 10.630  -2.572  -8.560  1.00 27.27 ? 254 GLU A CA  1 
ATOM   2095 C  C   . GLU A 1 254 ? 12.133  -2.608  -8.424  1.00 26.23 ? 254 GLU A C   1 
ATOM   2096 O  O   . GLU A 1 254 ? 12.864  -2.046  -9.202  1.00 26.54 ? 254 GLU A O   1 
ATOM   2097 C  CB  . GLU A 1 254 ? 10.164  -1.477  -9.529  1.00 31.04 ? 254 GLU A CB  1 
ATOM   2098 C  CG  . GLU A 1 254 ? 8.783   -1.809  -10.063 1.00 38.83 ? 254 GLU A CG  1 
ATOM   2099 C  CD  . GLU A 1 254 ? 7.989   -0.587  -10.512 1.00 48.74 ? 254 GLU A CD  1 
ATOM   2100 O  OE1 . GLU A 1 254 ? 8.560   0.539   -10.557 1.00 47.94 ? 254 GLU A OE1 1 
ATOM   2101 O  OE2 . GLU A 1 254 ? 6.776   -0.759  -10.811 1.00 48.74 ? 254 GLU A OE2 1 
ATOM   2102 N  N   . ARG A 1 255 ? 12.573  -3.299  -7.394  1.00 23.38 ? 255 ARG A N   1 
ATOM   2103 C  CA  . ARG A 1 255 ? 14.000  -3.467  -7.119  1.00 22.45 ? 255 ARG A CA  1 
ATOM   2104 C  C   . ARG A 1 255 ? 14.270  -4.884  -6.637  1.00 23.02 ? 255 ARG A C   1 
ATOM   2105 O  O   . ARG A 1 255 ? 13.373  -5.617  -6.182  1.00 23.26 ? 255 ARG A O   1 
ATOM   2106 C  CB  . ARG A 1 255 ? 14.454  -2.477  -6.070  1.00 20.65 ? 255 ARG A CB  1 
ATOM   2107 C  CG  . ARG A 1 255 ? 14.462  -1.044  -6.558  1.00 21.08 ? 255 ARG A CG  1 
ATOM   2108 C  CD  . ARG A 1 255 ? 14.923  -0.091  -5.428  1.00 19.89 ? 255 ARG A CD  1 
ATOM   2109 N  NE  . ARG A 1 255 ? 16.347  -0.410  -5.250  1.00 20.02 ? 255 ARG A NE  1 
ATOM   2110 C  CZ  . ARG A 1 255 ? 17.057  -0.106  -4.171  1.00 21.59 ? 255 ARG A CZ  1 
ATOM   2111 N  NH1 . ARG A 1 255 ? 16.473  0.547   -3.175  1.00 21.88 ? 255 ARG A NH1 1 
ATOM   2112 N  NH2 . ARG A 1 255 ? 18.328  -0.522  -4.115  1.00 17.44 ? 255 ARG A NH2 1 
ATOM   2113 N  N   . LEU A 1 256 ? 15.517  -5.290  -6.756  1.00 19.74 ? 256 LEU A N   1 
ATOM   2114 C  CA  . LEU A 1 256 ? 15.835  -6.575  -6.299  1.00 18.45 ? 256 LEU A CA  1 
ATOM   2115 C  C   . LEU A 1 256 ? 16.879  -6.486  -5.177  1.00 15.48 ? 256 LEU A C   1 
ATOM   2116 O  O   . LEU A 1 256 ? 17.617  -5.485  -5.010  1.00 17.63 ? 256 LEU A O   1 
ATOM   2117 C  CB  . LEU A 1 256 ? 16.396  -7.413  -7.437  1.00 21.25 ? 256 LEU A CB  1 
ATOM   2118 C  CG  . LEU A 1 256 ? 15.439  -7.634  -8.632  1.00 25.26 ? 256 LEU A CG  1 
ATOM   2119 C  CD1 . LEU A 1 256 ? 16.276  -8.201  -9.743  1.00 27.21 ? 256 LEU A CD1 1 
ATOM   2120 C  CD2 . LEU A 1 256 ? 14.408  -8.701  -8.255  1.00 28.35 ? 256 LEU A CD2 1 
ATOM   2121 N  N   . VAL A 1 257 ? 16.911  -7.569  -4.459  1.00 19.25 ? 257 VAL A N   1 
ATOM   2122 C  CA  . VAL A 1 257 ? 17.977  -7.779  -3.538  1.00 14.53 ? 257 VAL A CA  1 
ATOM   2123 C  C   . VAL A 1 257 ? 18.740  -8.990  -4.085  1.00 13.81 ? 257 VAL A C   1 
ATOM   2124 O  O   . VAL A 1 257 ? 18.135  -10.096 -4.302  1.00 16.54 ? 257 VAL A O   1 
ATOM   2125 C  CB  . VAL A 1 257 ? 17.419  -8.063  -2.126  1.00 16.49 ? 257 VAL A CB  1 
ATOM   2126 C  CG1 . VAL A 1 257 ? 18.505  -8.591  -1.203  1.00 16.02 ? 257 VAL A CG1 1 
ATOM   2127 C  CG2 . VAL A 1 257 ? 16.803  -6.829  -1.553  1.00 17.20 ? 257 VAL A CG2 1 
ATOM   2128 N  N   . TYR A 1 258 ? 20.037  -8.854  -4.249  1.00 12.60 ? 258 TYR A N   1 
ATOM   2129 C  CA  . TYR A 1 258 ? 20.844  -9.884  -4.837  1.00 13.29 ? 258 TYR A CA  1 
ATOM   2130 C  C   . TYR A 1 258 ? 21.270  -10.797 -3.777  1.00 13.45 ? 258 TYR A C   1 
ATOM   2131 O  O   . TYR A 1 258 ? 21.556  -10.345 -2.654  1.00 13.05 ? 258 TYR A O   1 
ATOM   2132 C  CB  . TYR A 1 258 ? 21.999  -9.300  -5.615  1.00 13.82 ? 258 TYR A CB  1 
ATOM   2133 C  CG  . TYR A 1 258 ? 21.407  -8.380  -6.651  1.00 17.59 ? 258 TYR A CG  1 
ATOM   2134 C  CD1 . TYR A 1 258 ? 20.808  -8.912  -7.803  1.00 19.77 ? 258 TYR A CD1 1 
ATOM   2135 C  CD2 . TYR A 1 258 ? 21.340  -7.031  -6.422  1.00 17.43 ? 258 TYR A CD2 1 
ATOM   2136 C  CE1 . TYR A 1 258 ? 20.190  -8.070  -8.765  1.00 22.86 ? 258 TYR A CE1 1 
ATOM   2137 C  CE2 . TYR A 1 258 ? 20.720  -6.183  -7.350  1.00 21.43 ? 258 TYR A CE2 1 
ATOM   2138 C  CZ  . TYR A 1 258 ? 20.177  -6.728  -8.526  1.00 22.40 ? 258 TYR A CZ  1 
ATOM   2139 O  OH  . TYR A 1 258 ? 19.571  -5.810  -9.388  1.00 23.96 ? 258 TYR A OH  1 
ATOM   2140 N  N   . THR A 1 259 ? 21.379  -12.077 -4.088  1.00 12.79 ? 259 THR A N   1 
ATOM   2141 C  CA  . THR A 1 259 ? 21.805  -13.049 -3.060  1.00 12.00 ? 259 THR A CA  1 
ATOM   2142 C  C   . THR A 1 259 ? 23.003  -13.808 -3.557  1.00 12.07 ? 259 THR A C   1 
ATOM   2143 O  O   . THR A 1 259 ? 23.182  -14.107 -4.780  1.00 12.06 ? 259 THR A O   1 
ATOM   2144 C  CB  . THR A 1 259 ? 20.712  -14.063 -2.601  1.00 12.92 ? 259 THR A CB  1 
ATOM   2145 O  OG1 . THR A 1 259 ? 20.294  -14.695 -3.788  1.00 17.96 ? 259 THR A OG1 1 
ATOM   2146 C  CG2 . THR A 1 259 ? 19.565  -13.348 -2.007  1.00 13.31 ? 259 THR A CG2 1 
ATOM   2147 N  N   . SER A 1 260 ? 23.882  -14.151 -2.687  1.00 10.84 ? 260 SER A N   1 
ATOM   2148 C  CA  . SER A 1 260 ? 25.073  -14.927 -3.081  1.00 12.56 ? 260 SER A CA  1 
ATOM   2149 C  C   . SER A 1 260 ? 24.747  -16.414 -3.072  1.00 14.43 ? 260 SER A C   1 
ATOM   2150 O  O   . SER A 1 260 ? 25.627  -17.222 -3.332  1.00 17.74 ? 260 SER A O   1 
ATOM   2151 C  CB  . SER A 1 260 ? 26.255  -14.671 -2.154  1.00 13.23 ? 260 SER A CB  1 
ATOM   2152 O  OG  . SER A 1 260 ? 25.900  -15.138 -0.817  1.00 11.54 ? 260 SER A OG  1 
ATOM   2153 N  N   . PHE A 1 261 ? 23.527  -16.771 -2.731  1.00 15.52 ? 261 PHE A N   1 
ATOM   2154 C  CA  . PHE A 1 261 ? 23.153  -18.168 -2.582  1.00 17.01 ? 261 PHE A CA  1 
ATOM   2155 C  C   . PHE A 1 261 ? 21.897  -18.343 -3.419  1.00 18.61 ? 261 PHE A C   1 
ATOM   2156 O  O   . PHE A 1 261 ? 21.092  -17.423 -3.629  1.00 20.47 ? 261 PHE A O   1 
ATOM   2157 C  CB  . PHE A 1 261 ? 22.939  -18.498 -1.083  1.00 14.87 ? 261 PHE A CB  1 
ATOM   2158 C  CG  . PHE A 1 261 ? 21.953  -17.596 -0.431  1.00 14.93 ? 261 PHE A CG  1 
ATOM   2159 C  CD1 . PHE A 1 261 ? 20.574  -17.879 -0.438  1.00 14.52 ? 261 PHE A CD1 1 
ATOM   2160 C  CD2 . PHE A 1 261 ? 22.365  -16.414 0.147   1.00 13.20 ? 261 PHE A CD2 1 
ATOM   2161 C  CE1 . PHE A 1 261 ? 19.662  -17.043 0.200   1.00 16.26 ? 261 PHE A CE1 1 
ATOM   2162 C  CE2 . PHE A 1 261 ? 21.471  -15.550 0.745   1.00 14.41 ? 261 PHE A CE2 1 
ATOM   2163 C  CZ  . PHE A 1 261 ? 20.086  -15.858 0.781   1.00 15.02 ? 261 PHE A CZ  1 
ATOM   2164 N  N   . SER A 1 262 ? 21.727  -19.563 -3.940  1.00 27.84 ? 262 SER A N   1 
ATOM   2165 C  CA  . SER A 1 262 ? 20.473  -19.930 -4.662  1.00 32.41 ? 262 SER A CA  1 
ATOM   2166 C  C   . SER A 1 262 ? 19.473  -20.684 -3.765  1.00 42.78 ? 262 SER A C   1 
ATOM   2167 O  O   . SER A 1 262 ? 19.834  -21.330 -2.779  1.00 45.13 ? 262 SER A O   1 
ATOM   2168 C  CB  . SER A 1 262 ? 20.739  -20.763 -5.935  1.00 35.30 ? 262 SER A CB  1 
ATOM   2169 O  OG  . SER A 1 262 ? 22.056  -21.281 -5.958  1.00 38.55 ? 262 SER A OG  1 
ATOM   2170 N  N   . LYS B 1 3   ? -1.106  17.584  -2.095  1.00 32.36 ? 3   LYS B N   1 
ATOM   2171 C  CA  . LYS B 1 3   ? -0.024  17.047  -2.981  1.00 26.16 ? 3   LYS B CA  1 
ATOM   2172 C  C   . LYS B 1 3   ? 0.807   15.891  -2.371  1.00 21.80 ? 3   LYS B C   1 
ATOM   2173 O  O   . LYS B 1 3   ? 1.743   15.386  -3.000  1.00 20.00 ? 3   LYS B O   1 
ATOM   2174 C  CB  . LYS B 1 3   ? 0.889   18.149  -3.512  1.00 33.40 ? 3   LYS B CB  1 
ATOM   2175 C  CG  . LYS B 1 3   ? 1.987   18.614  -2.606  1.00 34.86 ? 3   LYS B CG  1 
ATOM   2176 C  CD  . LYS B 1 3   ? 2.800   19.674  -3.377  1.00 41.40 ? 3   LYS B CD  1 
ATOM   2177 C  CE  . LYS B 1 3   ? 3.696   19.066  -4.456  1.00 41.57 ? 3   LYS B CE  1 
ATOM   2178 N  NZ  . LYS B 1 3   ? 5.109   18.801  -4.016  1.00 37.34 ? 3   LYS B NZ  1 
ATOM   2179 N  N   . TRP B 1 4   ? 0.431   15.450  -1.156  1.00 13.71 ? 4   TRP B N   1 
ATOM   2180 C  CA  . TRP B 1 4   ? 1.078   14.298  -0.559  1.00 11.46 ? 4   TRP B CA  1 
ATOM   2181 C  C   . TRP B 1 4   ? 0.722   13.101  -1.436  1.00 9.76  ? 4   TRP B C   1 
ATOM   2182 O  O   . TRP B 1 4   ? -0.303  13.029  -2.165  1.00 11.45 ? 4   TRP B O   1 
ATOM   2183 C  CB  . TRP B 1 4   ? 0.549   14.083  0.863   1.00 9.44  ? 4   TRP B CB  1 
ATOM   2184 C  CG  . TRP B 1 4   ? -0.933  13.759  1.008   1.00 8.66  ? 4   TRP B CG  1 
ATOM   2185 C  CD1 . TRP B 1 4   ? -1.977  14.648  1.312   1.00 9.39  ? 4   TRP B CD1 1 
ATOM   2186 C  CD2 . TRP B 1 4   ? -1.568  12.430  0.985   1.00 8.55  ? 4   TRP B CD2 1 
ATOM   2187 N  NE1 . TRP B 1 4   ? -3.174  14.004  1.406   1.00 9.45  ? 4   TRP B NE1 1 
ATOM   2188 C  CE2 . TRP B 1 4   ? -2.975  12.648  1.237   1.00 8.26  ? 4   TRP B CE2 1 
ATOM   2189 C  CE3 . TRP B 1 4   ? -1.095  11.144  0.812   1.00 8.34  ? 4   TRP B CE3 1 
ATOM   2190 C  CZ2 . TRP B 1 4   ? -3.897  11.555  1.368   1.00 8.43  ? 4   TRP B CZ2 1 
ATOM   2191 C  CZ3 . TRP B 1 4   ? -2.043  10.087  0.890   1.00 7.40  ? 4   TRP B CZ3 1 
ATOM   2192 C  CH2 . TRP B 1 4   ? -3.356  10.294  1.115   1.00 7.59  ? 4   TRP B CH2 1 
ATOM   2193 N  N   . THR B 1 5   ? 1.624   12.132  -1.380  1.00 8.98  ? 5   THR B N   1 
ATOM   2194 C  CA  . THR B 1 5   ? 1.506   10.928  -2.216  1.00 8.70  ? 5   THR B CA  1 
ATOM   2195 C  C   . THR B 1 5   ? 1.940   9.726   -1.397  1.00 8.77  ? 5   THR B C   1 
ATOM   2196 O  O   . THR B 1 5   ? 2.317   9.829   -0.209  1.00 7.94  ? 5   THR B O   1 
ATOM   2197 C  CB  . THR B 1 5   ? 2.405   10.887  -3.431  1.00 9.38  ? 5   THR B CB  1 
ATOM   2198 O  OG1 . THR B 1 5   ? 3.735   10.913  -2.955  1.00 11.41 ? 5   THR B OG1 1 
ATOM   2199 C  CG2 . THR B 1 5   ? 2.136   12.128  -4.348  1.00 11.57 ? 5   THR B CG2 1 
ATOM   2200 N  N   . TYR B 1 6   ? 1.939   8.561   -2.020  1.00 9.83  ? 6   TYR B N   1 
ATOM   2201 C  CA  . TYR B 1 6   ? 2.561   7.386   -1.413  1.00 9.03  ? 6   TYR B CA  1 
ATOM   2202 C  C   . TYR B 1 6   ? 3.910   6.960   -1.965  1.00 10.82 ? 6   TYR B C   1 
ATOM   2203 O  O   . TYR B 1 6   ? 4.442   5.888   -1.625  1.00 10.95 ? 6   TYR B O   1 
ATOM   2204 C  CB  . TYR B 1 6   ? 1.588   6.184   -1.602  1.00 8.39  ? 6   TYR B CB  1 
ATOM   2205 C  CG  . TYR B 1 6   ? 0.339   6.278   -0.767  1.00 7.29  ? 6   TYR B CG  1 
ATOM   2206 C  CD1 . TYR B 1 6   ? 0.350   5.731   0.540   1.00 7.88  ? 6   TYR B CD1 1 
ATOM   2207 C  CD2 . TYR B 1 6   ? -0.840  6.780   -1.250  1.00 7.35  ? 6   TYR B CD2 1 
ATOM   2208 C  CE1 . TYR B 1 6   ? -0.812  5.715   1.332   1.00 7.40  ? 6   TYR B CE1 1 
ATOM   2209 C  CE2 . TYR B 1 6   ? -2.012  6.768   -0.487  1.00 7.06  ? 6   TYR B CE2 1 
ATOM   2210 C  CZ  . TYR B 1 6   ? -1.931  6.255   0.825   1.00 7.57  ? 6   TYR B CZ  1 
ATOM   2211 O  OH  . TYR B 1 6   ? -3.120  6.236   1.457   1.00 8.01  ? 6   TYR B OH  1 
ATOM   2212 N  N   . PHE B 1 7   ? 4.472   7.778   -2.834  1.00 12.50 ? 7   PHE B N   1 
ATOM   2213 C  CA  . PHE B 1 7   ? 5.676   7.434   -3.507  1.00 14.03 ? 7   PHE B CA  1 
ATOM   2214 C  C   . PHE B 1 7   ? 6.429   8.711   -3.855  1.00 15.07 ? 7   PHE B C   1 
ATOM   2215 O  O   . PHE B 1 7   ? 5.877   9.564   -4.522  1.00 15.82 ? 7   PHE B O   1 
ATOM   2216 C  CB  . PHE B 1 7   ? 5.405   6.707   -4.866  1.00 19.26 ? 7   PHE B CB  1 
ATOM   2217 C  CG  . PHE B 1 7   ? 6.654   6.317   -5.618  1.00 22.61 ? 7   PHE B CG  1 
ATOM   2218 C  CD1 . PHE B 1 7   ? 7.541   5.330   -5.128  1.00 25.19 ? 7   PHE B CD1 1 
ATOM   2219 C  CD2 . PHE B 1 7   ? 6.942   6.927   -6.867  1.00 29.02 ? 7   PHE B CD2 1 
ATOM   2220 C  CE1 . PHE B 1 7   ? 8.696   4.959   -5.821  1.00 30.21 ? 7   PHE B CE1 1 
ATOM   2221 C  CE2 . PHE B 1 7   ? 8.081   6.539   -7.584  1.00 32.47 ? 7   PHE B CE2 1 
ATOM   2222 C  CZ  . PHE B 1 7   ? 8.958   5.568   -7.064  1.00 33.26 ? 7   PHE B CZ  1 
ATOM   2223 N  N   . GLY B 1 8   ? 7.726   8.710   -3.565  1.00 14.94 ? 8   GLY B N   1 
ATOM   2224 C  CA  . GLY B 1 8   ? 8.528   9.790   -4.136  1.00 14.84 ? 8   GLY B CA  1 
ATOM   2225 C  C   . GLY B 1 8   ? 8.735   10.827  -3.069  1.00 15.03 ? 8   GLY B C   1 
ATOM   2226 O  O   . GLY B 1 8   ? 8.539   10.591  -1.854  1.00 13.74 ? 8   GLY B O   1 
ATOM   2227 N  N   . PRO B 1 9   ? 9.124   12.029  -3.473  1.00 15.26 ? 9   PRO B N   1 
ATOM   2228 C  CA  . PRO B 1 9   ? 9.511   13.042  -2.533  1.00 16.40 ? 9   PRO B CA  1 
ATOM   2229 C  C   . PRO B 1 9   ? 8.432   13.529  -1.591  1.00 14.90 ? 9   PRO B C   1 
ATOM   2230 O  O   . PRO B 1 9   ? 8.770   14.006  -0.509  1.00 14.47 ? 9   PRO B O   1 
ATOM   2231 C  CB  . PRO B 1 9   ? 10.046  14.214  -3.412  1.00 18.85 ? 9   PRO B CB  1 
ATOM   2232 C  CG  . PRO B 1 9   ? 9.656   13.865  -4.744  1.00 20.53 ? 9   PRO B CG  1 
ATOM   2233 C  CD  . PRO B 1 9   ? 9.398   12.375  -4.879  1.00 17.86 ? 9   PRO B CD  1 
ATOM   2234 N  N   . ASP B 1 10  ? 7.160   13.372  -1.974  1.00 11.78 ? 10  ASP B N   1 
ATOM   2235 C  CA  . ASP B 1 10  ? 6.031   13.725  -1.159  1.00 11.36 ? 10  ASP B CA  1 
ATOM   2236 C  C   . ASP B 1 10  ? 5.319   12.522  -0.486  1.00 9.32  ? 10  ASP B C   1 
ATOM   2237 O  O   . ASP B 1 10  ? 4.218   12.684  0.011   1.00 8.85  ? 10  ASP B O   1 
ATOM   2238 C  CB  . ASP B 1 10  ? 5.003   14.552  -1.972  1.00 14.16 ? 10  ASP B CB  1 
ATOM   2239 C  CG  . ASP B 1 10  ? 5.613   15.861  -2.539  1.00 19.88 ? 10  ASP B CG  1 
ATOM   2240 O  OD1 . ASP B 1 10  ? 6.251   16.579  -1.790  1.00 21.96 ? 10  ASP B OD1 1 
ATOM   2241 O  OD2 . ASP B 1 10  ? 5.460   16.145  -3.742  1.00 23.79 ? 10  ASP B OD2 1 
ATOM   2242 N  N   . GLY B 1 11  ? 6.071   11.418  -0.481  1.00 8.78  ? 11  GLY B N   1 
ATOM   2243 C  CA  . GLY B 1 11  ? 5.559   10.156  0.135   1.00 7.82  ? 11  GLY B CA  1 
ATOM   2244 C  C   . GLY B 1 11  ? 5.641   10.190  1.646   1.00 7.26  ? 11  GLY B C   1 
ATOM   2245 O  O   . GLY B 1 11  ? 5.840   11.200  2.325   1.00 5.98  ? 11  GLY B O   1 
ATOM   2246 N  N   . GLU B 1 12  ? 5.379   9.022   2.269   1.00 6.78  ? 12  GLU B N   1 
ATOM   2247 C  CA  . GLU B 1 12  ? 4.947   8.990   3.662   1.00 6.54  ? 12  GLU B CA  1 
ATOM   2248 C  C   . GLU B 1 12  ? 5.984   9.486   4.695   1.00 5.83  ? 12  GLU B C   1 
ATOM   2249 O  O   . GLU B 1 12  ? 5.623   9.922   5.728   1.00 6.66  ? 12  GLU B O   1 
ATOM   2250 C  CB  . GLU B 1 12  ? 4.495   7.516   4.042   1.00 6.87  ? 12  GLU B CB  1 
ATOM   2251 C  CG  . GLU B 1 12  ? 5.589   6.486   4.211   1.00 7.20  ? 12  GLU B CG  1 
ATOM   2252 C  CD  . GLU B 1 12  ? 4.970   5.112   4.100   1.00 7.73  ? 12  GLU B CD  1 
ATOM   2253 O  OE1 . GLU B 1 12  ? 4.556   4.656   5.174   1.00 6.95  ? 12  GLU B OE1 1 
ATOM   2254 O  OE2 . GLU B 1 12  ? 4.855   4.639   2.972   1.00 9.01  ? 12  GLU B OE2 1 
ATOM   2255 N  N   . ASN B 1 13  ? 7.275   9.339   4.347   1.00 6.61  ? 13  ASN B N   1 
ATOM   2256 C  CA  . ASN B 1 13  ? 8.275   9.828   5.293   1.00 6.79  ? 13  ASN B CA  1 
ATOM   2257 C  C   . ASN B 1 13  ? 8.353   11.383  5.339   1.00 7.49  ? 13  ASN B C   1 
ATOM   2258 O  O   . ASN B 1 13  ? 8.889   11.939  6.300   1.00 7.94  ? 13  ASN B O   1 
ATOM   2259 C  CB  . ASN B 1 13  ? 9.665   9.315   4.949   1.00 6.60  ? 13  ASN B CB  1 
ATOM   2260 C  CG  . ASN B 1 13  ? 9.849   7.857   5.263   1.00 6.63  ? 13  ASN B CG  1 
ATOM   2261 O  OD1 . ASN B 1 13  ? 8.917   7.184   5.755   1.00 7.74  ? 13  ASN B OD1 1 
ATOM   2262 N  ND2 . ASN B 1 13  ? 10.989  7.347   4.844   1.00 6.85  ? 13  ASN B ND2 1 
ATOM   2263 N  N   . SER B 1 14  ? 7.652   11.970  4.368   1.00 6.84  ? 14  SER B N   1 
ATOM   2264 C  CA  . SER B 1 14  ? 7.551   13.466  4.301   1.00 6.88  ? 14  SER B CA  1 
ATOM   2265 C  C   . SER B 1 14  ? 6.247   14.000  4.721   1.00 6.64  ? 14  SER B C   1 
ATOM   2266 O  O   . SER B 1 14  ? 6.104   15.247  4.866   1.00 7.10  ? 14  SER B O   1 
ATOM   2267 C  CB  . SER B 1 14  ? 7.851   13.946  2.949   1.00 7.96  ? 14  SER B CB  1 
ATOM   2268 O  OG  . SER B 1 14  ? 9.188   13.657  2.575   1.00 9.40  ? 14  SER B OG  1 
ATOM   2269 N  N   . TRP B 1 15  ? 5.223   13.203  5.007   1.00 5.91  ? 15  TRP B N   1 
ATOM   2270 C  CA  . TRP B 1 15  ? 3.924   13.749  5.381   1.00 6.14  ? 15  TRP B CA  1 
ATOM   2271 C  C   . TRP B 1 15  ? 3.989   14.673  6.587   1.00 7.26  ? 15  TRP B C   1 
ATOM   2272 O  O   . TRP B 1 15  ? 3.267   15.670  6.662   1.00 8.17  ? 15  TRP B O   1 
ATOM   2273 C  CB  . TRP B 1 15  ? 2.906   12.616  5.722   1.00 5.94  ? 15  TRP B CB  1 
ATOM   2274 C  CG  . TRP B 1 15  ? 2.563   11.796  4.574   1.00 5.76  ? 15  TRP B CG  1 
ATOM   2275 C  CD1 . TRP B 1 15  ? 2.879   11.938  3.241   1.00 5.78  ? 15  TRP B CD1 1 
ATOM   2276 C  CD2 . TRP B 1 15  ? 1.762   10.525  4.684   1.00 5.38  ? 15  TRP B CD2 1 
ATOM   2277 N  NE1 . TRP B 1 15  ? 2.263   10.897  2.471   1.00 6.36  ? 15  TRP B NE1 1 
ATOM   2278 C  CE2 . TRP B 1 15  ? 1.628   10.015  3.321   1.00 5.58  ? 15  TRP B CE2 1 
ATOM   2279 C  CE3 . TRP B 1 15  ? 1.188   9.826   5.740   1.00 5.50  ? 15  TRP B CE3 1 
ATOM   2280 C  CZ2 . TRP B 1 15  ? 0.930   8.846   3.009   1.00 6.19  ? 15  TRP B CZ2 1 
ATOM   2281 C  CZ3 . TRP B 1 15  ? 0.447   8.662   5.441   1.00 5.46  ? 15  TRP B CZ3 1 
ATOM   2282 C  CH2 . TRP B 1 15  ? 0.354   8.194   4.127   1.00 5.14  ? 15  TRP B CH2 1 
ATOM   2283 N  N   . SER B 1 16  ? 4.818   14.355  7.566   1.00 7.52  ? 16  SER B N   1 
ATOM   2284 C  CA  . SER B 1 16  ? 4.866   15.108  8.798   1.00 7.84  ? 16  SER B CA  1 
ATOM   2285 C  C   . SER B 1 16  ? 5.406   16.549  8.617   1.00 8.62  ? 16  SER B C   1 
ATOM   2286 O  O   . SER B 1 16  ? 5.162   17.338  9.519   1.00 10.19 ? 16  SER B O   1 
ATOM   2287 C  CB  . SER B 1 16  ? 5.780   14.419  9.813   1.00 8.52  ? 16  SER B CB  1 
ATOM   2288 O  OG  . SER B 1 16  ? 7.120   14.565  9.352   1.00 12.45 ? 16  SER B OG  1 
ATOM   2289 N  N   . LYS B 1 17  ? 5.994   16.810  7.455   1.00 8.18  ? 17  LYS B N   1 
ATOM   2290 C  CA  . LYS B 1 17  ? 6.412   18.213  7.189   1.00 8.12  ? 17  LYS B CA  1 
ATOM   2291 C  C   . LYS B 1 17  ? 5.239   19.070  7.081   1.00 9.90  ? 17  LYS B C   1 
ATOM   2292 O  O   . LYS B 1 17  ? 5.414   20.279  7.441   1.00 10.42 ? 17  LYS B O   1 
ATOM   2293 C  CB  . LYS B 1 17  ? 7.221   18.264  5.901   1.00 8.46  ? 17  LYS B CB  1 
ATOM   2294 C  CG  . LYS B 1 17  ? 8.516   17.426  5.832   1.00 9.21  ? 17  LYS B CG  1 
ATOM   2295 C  CD  . LYS B 1 17  ? 9.131   17.440  4.456   1.00 8.37  ? 17  LYS B CD  1 
ATOM   2296 C  CE  . LYS B 1 17  ? 10.250  16.465  4.266   1.00 9.32  ? 17  LYS B CE  1 
ATOM   2297 N  NZ  . LYS B 1 17  ? 10.900  16.613  2.968   1.00 10.44 ? 17  LYS B NZ  1 
ATOM   2298 N  N   . LYS B 1 18  ? 4.151   18.676  6.498   1.00 9.25  ? 18  LYS B N   1 
ATOM   2299 C  CA  . LYS B 1 18  ? 2.939   19.498  6.361   1.00 9.33  ? 18  LYS B CA  1 
ATOM   2300 C  C   . LYS B 1 18  ? 1.835   19.093  7.337   1.00 10.63 ? 18  LYS B C   1 
ATOM   2301 O  O   . LYS B 1 18  ? 0.952   19.908  7.598   1.00 11.82 ? 18  LYS B O   1 
ATOM   2302 C  CB  . LYS B 1 18  ? 2.364   19.349  4.943   1.00 11.94 ? 18  LYS B CB  1 
ATOM   2303 C  CG  . LYS B 1 18  ? 3.303   19.908  3.852   1.00 18.50 ? 18  LYS B CG  1 
ATOM   2304 C  CD  . LYS B 1 18  ? 2.789   19.684  2.392   1.00 19.53 ? 18  LYS B CD  1 
ATOM   2305 C  CE  . LYS B 1 18  ? 3.346   20.777  1.439   1.00 29.15 ? 18  LYS B CE  1 
ATOM   2306 N  NZ  . LYS B 1 18  ? 2.552   20.755  0.142   1.00 28.50 ? 18  LYS B NZ  1 
ATOM   2307 N  N   . TYR B 1 19  ? 1.851   17.855  7.864   1.00 8.80  ? 19  TYR B N   1 
ATOM   2308 C  CA  . TYR B 1 19  ? 0.756   17.369  8.678   1.00 10.18 ? 19  TYR B CA  1 
ATOM   2309 C  C   . TYR B 1 19  ? 1.351   16.860  9.973   1.00 9.16  ? 19  TYR B C   1 
ATOM   2310 O  O   . TYR B 1 19  ? 1.804   15.644  10.039  1.00 8.34  ? 19  TYR B O   1 
ATOM   2311 C  CB  . TYR B 1 19  ? 0.086   16.176  7.909   1.00 8.54  ? 19  TYR B CB  1 
ATOM   2312 C  CG  . TYR B 1 19  ? -0.487  16.614  6.593   1.00 7.57  ? 19  TYR B CG  1 
ATOM   2313 C  CD1 . TYR B 1 19  ? -1.709  17.271  6.537   1.00 9.53  ? 19  TYR B CD1 1 
ATOM   2314 C  CD2 . TYR B 1 19  ? 0.205   16.408  5.409   1.00 7.54  ? 19  TYR B CD2 1 
ATOM   2315 C  CE1 . TYR B 1 19  ? -2.238  17.690  5.335   1.00 10.09 ? 19  TYR B CE1 1 
ATOM   2316 C  CE2 . TYR B 1 19  ? -0.318  16.820  4.202   1.00 9.23  ? 19  TYR B CE2 1 
ATOM   2317 C  CZ  . TYR B 1 19  ? -1.539  17.461  4.172   1.00 11.45 ? 19  TYR B CZ  1 
ATOM   2318 O  OH  . TYR B 1 19  ? -2.056  17.873  2.967   1.00 15.93 ? 19  TYR B OH  1 
ATOM   2319 N  N   . PRO B 1 20  ? 1.523   17.688  10.971  1.00 9.91  ? 20  PRO B N   1 
ATOM   2320 C  CA  . PRO B 1 20  ? 2.294   17.306  12.114  1.00 10.63 ? 20  PRO B CA  1 
ATOM   2321 C  C   . PRO B 1 20  ? 1.777   16.055  12.806  1.00 9.26  ? 20  PRO B C   1 
ATOM   2322 O  O   . PRO B 1 20  ? 2.644   15.346  13.400  1.00 10.39 ? 20  PRO B O   1 
ATOM   2323 C  CB  . PRO B 1 20  ? 2.215   18.531  13.050  1.00 13.34 ? 20  PRO B CB  1 
ATOM   2324 C  CG  . PRO B 1 20  ? 1.784   19.633  12.172  1.00 14.02 ? 20  PRO B CG  1 
ATOM   2325 C  CD  . PRO B 1 20  ? 1.051   19.112  10.985  1.00 10.65 ? 20  PRO B CD  1 
ATOM   2326 N  N   . SER B 1 21  ? 0.488   15.748  12.756  1.00 9.04  ? 21  SER B N   1 
ATOM   2327 C  CA  . SER B 1 21  ? 0.038   14.543  13.527  1.00 8.65  ? 21  SER B CA  1 
ATOM   2328 C  C   . SER B 1 21  ? 0.613   13.311  12.876  1.00 7.58  ? 21  SER B C   1 
ATOM   2329 O  O   . SER B 1 21  ? 0.618   12.313  13.567  1.00 7.87  ? 21  SER B O   1 
ATOM   2330 C  CB  . SER B 1 21  ? -1.454  14.436  13.538  1.00 8.43  ? 21  SER B CB  1 
ATOM   2331 O  OG  . SER B 1 21  ? -1.990  15.518  14.303  1.00 11.96 ? 21  SER B OG  1 
ATOM   2332 N  N   . CYS B 1 22  ? 1.067   13.332  11.625  1.00 7.58  ? 22  CYS B N   1 
ATOM   2333 C  CA  . CYS B 1 22  ? 1.689   12.143  11.027  1.00 7.27  ? 22  CYS B CA  1 
ATOM   2334 C  C   . CYS B 1 22  ? 2.942   11.742  11.704  1.00 8.09  ? 22  CYS B C   1 
ATOM   2335 O  O   . CYS B 1 22  ? 3.400   10.598  11.485  1.00 9.51  ? 22  CYS B O   1 
ATOM   2336 C  CB  . CYS B 1 22  ? 1.938   12.350  9.536   1.00 7.31  ? 22  CYS B CB  1 
ATOM   2337 S  SG  . CYS B 1 22  ? 0.347   12.664  8.574   1.00 8.22  ? 22  CYS B SG  1 
ATOM   2338 N  N   . GLY B 1 23  ? 3.588   12.668  12.432  1.00 8.78  ? 23  GLY B N   1 
ATOM   2339 C  CA  . GLY B 1 23  ? 4.785   12.367  13.269  1.00 10.55 ? 23  GLY B CA  1 
ATOM   2340 C  C   . GLY B 1 23  ? 4.453   12.291  14.712  1.00 12.22 ? 23  GLY B C   1 
ATOM   2341 O  O   . GLY B 1 23  ? 5.356   12.216  15.584  1.00 13.87 ? 23  GLY B O   1 
ATOM   2342 N  N   . GLY B 1 24  ? 3.189   12.260  15.026  1.00 11.32 ? 24  GLY B N   1 
ATOM   2343 C  CA  . GLY B 1 24  ? 2.754   12.229  16.424  1.00 12.98 ? 24  GLY B CA  1 
ATOM   2344 C  C   . GLY B 1 24  ? 2.484   10.852  16.944  1.00 14.18 ? 24  GLY B C   1 
ATOM   2345 O  O   . GLY B 1 24  ? 3.010   9.838   16.455  1.00 16.54 ? 24  GLY B O   1 
ATOM   2346 N  N   . LEU B 1 25  ? 1.711   10.917  17.998  1.00 16.07 ? 25  LEU B N   1 
ATOM   2347 C  CA  . LEU B 1 25  ? 1.361   9.680   18.703  1.00 19.17 ? 25  LEU B CA  1 
ATOM   2348 C  C   . LEU B 1 25  ? 0.240   8.898   18.032  1.00 15.47 ? 25  LEU B C   1 
ATOM   2349 O  O   . LEU B 1 25  ? -0.494  9.445   17.213  1.00 15.46 ? 25  LEU B O   1 
ATOM   2350 C  CB  . LEU B 1 25  ? 1.000   10.017  20.153  1.00 24.46 ? 25  LEU B CB  1 
ATOM   2351 C  CG  . LEU B 1 25  ? 2.292   10.496  20.875  1.00 27.01 ? 25  LEU B CG  1 
ATOM   2352 C  CD1 . LEU B 1 25  ? 1.959   10.986  22.278  1.00 36.55 ? 25  LEU B CD1 1 
ATOM   2353 C  CD2 . LEU B 1 25  ? 3.487   9.526   20.881  1.00 26.29 ? 25  LEU B CD2 1 
ATOM   2354 N  N   . LEU B 1 26  ? 0.056   7.635   18.477  1.00 16.34 ? 26  LEU B N   1 
ATOM   2355 C  CA  . LEU B 1 26  ? -1.086  6.788   18.195  1.00 13.83 ? 26  LEU B CA  1 
ATOM   2356 C  C   . LEU B 1 26  ? -1.229  6.487   16.696  1.00 9.82  ? 26  LEU B C   1 
ATOM   2357 O  O   . LEU B 1 26  ? -2.401  6.375   16.210  1.00 11.10 ? 26  LEU B O   1 
ATOM   2358 C  CB  . LEU B 1 26  ? -2.384  7.324   18.754  1.00 16.31 ? 26  LEU B CB  1 
ATOM   2359 C  CG  . LEU B 1 26  ? -2.553  7.464   20.292  1.00 20.31 ? 26  LEU B CG  1 
ATOM   2360 C  CD1 . LEU B 1 26  ? -4.007  7.841   20.542  1.00 24.15 ? 26  LEU B CD1 1 
ATOM   2361 C  CD2 . LEU B 1 26  ? -2.276  6.134   20.965  1.00 20.67 ? 26  LEU B CD2 1 
ATOM   2362 N  N   . GLN B 1 27  ? -0.116  6.364   15.977  1.00 8.78  ? 27  GLN B N   1 
ATOM   2363 C  CA  . GLN B 1 27  ? -0.271  6.201   14.500  1.00 7.65  ? 27  GLN B CA  1 
ATOM   2364 C  C   . GLN B 1 27  ? -0.595  4.807   14.077  1.00 7.90  ? 27  GLN B C   1 
ATOM   2365 O  O   . GLN B 1 27  ? -0.145  3.810   14.687  1.00 8.94  ? 27  GLN B O   1 
ATOM   2366 C  CB  . GLN B 1 27  ? 0.961   6.688   13.779  1.00 8.04  ? 27  GLN B CB  1 
ATOM   2367 C  CG  . GLN B 1 27  ? 1.236   8.177   13.978  1.00 8.22  ? 27  GLN B CG  1 
ATOM   2368 C  CD  . GLN B 1 27  ? 0.186   9.044   13.319  1.00 6.91  ? 27  GLN B CD  1 
ATOM   2369 O  OE1 . GLN B 1 27  ? 0.241   9.162   12.038  1.00 7.31  ? 27  GLN B OE1 1 
ATOM   2370 N  NE2 . GLN B 1 27  ? -0.761  9.512   14.046  1.00 7.86  ? 27  GLN B NE2 1 
ATOM   2371 N  N   . SER B 1 28  ? -1.373  4.752   13.008  1.00 6.04  ? 28  SER B N   1 
ATOM   2372 C  CA  . SER B 1 28  ? -1.757  3.491   12.311  1.00 5.63  ? 28  SER B CA  1 
ATOM   2373 C  C   . SER B 1 28  ? -1.217  3.547   10.916  1.00 6.01  ? 28  SER B C   1 
ATOM   2374 O  O   . SER B 1 28  ? -0.921  4.601   10.339  1.00 5.90  ? 28  SER B O   1 
ATOM   2375 C  CB  . SER B 1 28  ? -3.282  3.487   12.238  1.00 6.28  ? 28  SER B CB  1 
ATOM   2376 O  OG  . SER B 1 28  ? -3.853  3.385   13.559  1.00 6.01  ? 28  SER B OG  1 
ATOM   2377 N  N   . PRO B 1 29  ? -1.138  2.390   10.235  1.00 4.87  ? 29  PRO B N   1 
ATOM   2378 C  CA  . PRO B 1 29  ? -1.492  1.011   10.720  1.00 5.24  ? 29  PRO B CA  1 
ATOM   2379 C  C   . PRO B 1 29  ? -0.324  0.439   11.487  1.00 4.89  ? 29  PRO B C   1 
ATOM   2380 O  O   . PRO B 1 29  ? 0.723   1.037   11.675  1.00 5.37  ? 29  PRO B O   1 
ATOM   2381 C  CB  . PRO B 1 29  ? -1.693  0.297   9.357   1.00 4.96  ? 29  PRO B CB  1 
ATOM   2382 C  CG  . PRO B 1 29  ? -0.590  0.848   8.508   1.00 5.26  ? 29  PRO B CG  1 
ATOM   2383 C  CD  . PRO B 1 29  ? -0.661  2.371   8.832   1.00 5.39  ? 29  PRO B CD  1 
ATOM   2384 N  N   . ILE B 1 30  ? -0.590  -0.782  11.971  1.00 5.36  ? 30  ILE B N   1 
ATOM   2385 C  CA  . ILE B 1 30  ? 0.380   -1.522  12.789  1.00 5.47  ? 30  ILE B CA  1 
ATOM   2386 C  C   . ILE B 1 30  ? 0.378   -2.980  12.368  1.00 5.53  ? 30  ILE B C   1 
ATOM   2387 O  O   . ILE B 1 30  ? -0.527  -3.455  11.681  1.00 5.02  ? 30  ILE B O   1 
ATOM   2388 C  CB  . ILE B 1 30  ? 0.036   -1.432  14.273  1.00 6.20  ? 30  ILE B CB  1 
ATOM   2389 C  CG1 . ILE B 1 30  ? -1.364  -2.049  14.575  1.00 6.52  ? 30  ILE B CG1 1 
ATOM   2390 C  CG2 . ILE B 1 30  ? 0.154   0.055   14.734  1.00 7.34  ? 30  ILE B CG2 1 
ATOM   2391 C  CD1 . ILE B 1 30  ? -1.633  -2.073  16.063  1.00 7.86  ? 30  ILE B CD1 1 
ATOM   2392 N  N   . ASP B 1 31  ? 1.464   -3.647  12.811  1.00 5.43  ? 31  ASP B N   1 
ATOM   2393 C  CA  . ASP B 1 31  ? 1.586   -5.061  12.648  1.00 6.40  ? 31  ASP B CA  1 
ATOM   2394 C  C   . ASP B 1 31  ? 0.963   -5.759  13.876  1.00 8.19  ? 31  ASP B C   1 
ATOM   2395 O  O   . ASP B 1 31  ? 1.385   -5.543  15.032  1.00 8.90  ? 31  ASP B O   1 
ATOM   2396 C  CB  . ASP B 1 31  ? 3.062   -5.480  12.560  1.00 7.29  ? 31  ASP B CB  1 
ATOM   2397 C  CG  . ASP B 1 31  ? 3.218   -7.002  12.444  1.00 10.59 ? 31  ASP B CG  1 
ATOM   2398 O  OD1 . ASP B 1 31  ? 2.635   -7.628  11.538  1.00 10.04 ? 31  ASP B OD1 1 
ATOM   2399 O  OD2 . ASP B 1 31  ? 3.860   -7.585  13.351  1.00 14.85 ? 31  ASP B OD2 1 
ATOM   2400 N  N   . LEU B 1 32  ? 0.032   -6.628  13.568  1.00 7.85  ? 32  LEU B N   1 
ATOM   2401 C  CA  . LEU B 1 32  ? -0.686  -7.322  14.623  1.00 8.32  ? 32  LEU B CA  1 
ATOM   2402 C  C   . LEU B 1 32  ? 0.062   -8.617  14.932  1.00 9.04  ? 32  LEU B C   1 
ATOM   2403 O  O   . LEU B 1 32  ? 0.048   -9.475  14.112  1.00 10.99 ? 32  LEU B O   1 
ATOM   2404 C  CB  . LEU B 1 32  ? -2.112  -7.596  14.188  1.00 8.93  ? 32  LEU B CB  1 
ATOM   2405 C  CG  . LEU B 1 32  ? -2.898  -6.290  13.861  1.00 9.80  ? 32  LEU B CG  1 
ATOM   2406 C  CD1 . LEU B 1 32  ? -4.178  -6.600  13.107  1.00 10.30 ? 32  LEU B CD1 1 
ATOM   2407 C  CD2 . LEU B 1 32  ? -3.260  -5.436  15.081  1.00 10.78 ? 32  LEU B CD2 1 
ATOM   2408 N  N   . HIS B 1 33  ? 0.739   -8.696  16.052  1.00 8.44  ? 33  HIS B N   1 
ATOM   2409 C  CA  . HIS B 1 33  ? 1.516   -9.894  16.369  1.00 9.81  ? 33  HIS B CA  1 
ATOM   2410 C  C   . HIS B 1 33  ? 1.444   -10.106 17.827  1.00 8.98  ? 33  HIS B C   1 
ATOM   2411 O  O   . HIS B 1 33  ? 1.111   -9.222  18.633  1.00 9.28  ? 33  HIS B O   1 
ATOM   2412 C  CB  . HIS B 1 33  ? 3.004   -9.688  15.907  1.00 10.20 ? 33  HIS B CB  1 
ATOM   2413 C  CG  . HIS B 1 33  ? 3.717   -8.537  16.615  1.00 10.95 ? 33  HIS B CG  1 
ATOM   2414 N  ND1 . HIS B 1 33  ? 3.458   -7.221  16.364  1.00 13.42 ? 33  HIS B ND1 1 
ATOM   2415 C  CD2 . HIS B 1 33  ? 4.671   -8.525  17.624  1.00 11.78 ? 33  HIS B CD2 1 
ATOM   2416 C  CE1 . HIS B 1 33  ? 4.238   -6.429  17.172  1.00 15.86 ? 33  HIS B CE1 1 
ATOM   2417 N  NE2 . HIS B 1 33  ? 4.966   -7.241  17.910  1.00 14.68 ? 33  HIS B NE2 1 
ATOM   2418 N  N   . SER B 1 34  ? 1.852   -11.356 18.178  1.00 9.65  ? 34  SER B N   1 
ATOM   2419 C  CA  . SER B 1 34  ? 1.448   -11.888 19.505  1.00 11.34 ? 34  SER B CA  1 
ATOM   2420 C  C   . SER B 1 34  ? 1.928   -11.093 20.633  1.00 10.20 ? 34  SER B C   1 
ATOM   2421 O  O   . SER B 1 34  ? 1.202   -10.981 21.619  1.00 12.65 ? 34  SER B O   1 
ATOM   2422 C  CB  . SER B 1 34  ? 1.926   -13.351 19.628  1.00 12.42 ? 34  SER B CB  1 
ATOM   2423 O  OG  . SER B 1 34  ? 3.319   -13.377 19.499  1.00 18.21 ? 34  SER B OG  1 
ATOM   2424 N  N   . ASP B 1 35  ? 3.136   -10.546 20.573  1.00 10.41 ? 35  ASP B N   1 
ATOM   2425 C  CA  . ASP B 1 35  ? 3.706   -9.832  21.725  1.00 11.15 ? 35  ASP B CA  1 
ATOM   2426 C  C   . ASP B 1 35  ? 2.932   -8.670  22.210  1.00 12.43 ? 35  ASP B C   1 
ATOM   2427 O  O   . ASP B 1 35  ? 3.072   -8.199  23.328  1.00 15.97 ? 35  ASP B O   1 
ATOM   2428 C  CB  . ASP B 1 35  ? 5.143   -9.318  21.420  1.00 12.94 ? 35  ASP B CB  1 
ATOM   2429 C  CG  . ASP B 1 35  ? 6.004   -10.362 20.781  1.00 16.47 ? 35  ASP B CG  1 
ATOM   2430 O  OD1 . ASP B 1 35  ? 5.699   -10.802 19.652  1.00 20.30 ? 35  ASP B OD1 1 
ATOM   2431 O  OD2 . ASP B 1 35  ? 6.998   -10.749 21.416  1.00 18.76 ? 35  ASP B OD2 1 
ATOM   2432 N  N   . ILE B 1 36  ? 2.076   -8.136  21.345  1.00 11.77 ? 36  ILE B N   1 
ATOM   2433 C  CA  . ILE B 1 36  ? 1.332   -6.955  21.718  1.00 12.13 ? 36  ILE B CA  1 
ATOM   2434 C  C   . ILE B 1 36  ? -0.172  -7.167  21.813  1.00 10.83 ? 36  ILE B C   1 
ATOM   2435 O  O   . ILE B 1 36  ? -0.941  -6.215  21.952  1.00 11.45 ? 36  ILE B O   1 
ATOM   2436 C  CB  . ILE B 1 36  ? 1.583   -5.697  20.792  1.00 14.16 ? 36  ILE B CB  1 
ATOM   2437 C  CG1 . ILE B 1 36  ? 1.458   -6.102  19.317  1.00 15.95 ? 36  ILE B CG1 1 
ATOM   2438 C  CG2 . ILE B 1 36  ? 3.007   -5.144  20.996  1.00 17.37 ? 36  ILE B CG2 1 
ATOM   2439 C  CD1 . ILE B 1 36  ? 0.100   -6.139  18.814  1.00 18.94 ? 36  ILE B CD1 1 
ATOM   2440 N  N   . LEU B 1 37  ? -0.575  -8.426  21.731  1.00 9.87  ? 37  LEU B N   1 
ATOM   2441 C  CA  . LEU B 1 37  ? -2.016  -8.750  21.832  1.00 11.72 ? 37  LEU B CA  1 
ATOM   2442 C  C   . LEU B 1 37  ? -2.408  -9.030  23.261  1.00 13.05 ? 37  LEU B C   1 
ATOM   2443 O  O   . LEU B 1 37  ? -1.636  -9.612  24.048  1.00 14.70 ? 37  LEU B O   1 
ATOM   2444 C  CB  . LEU B 1 37  ? -2.350  -9.944  20.955  1.00 11.32 ? 37  LEU B CB  1 
ATOM   2445 C  CG  . LEU B 1 37  ? -2.015  -9.789  19.466  1.00 12.16 ? 37  LEU B CG  1 
ATOM   2446 C  CD1 . LEU B 1 37  ? -2.395  -11.036 18.716  1.00 14.36 ? 37  LEU B CD1 1 
ATOM   2447 C  CD2 . LEU B 1 37  ? -2.747  -8.624  18.808  1.00 11.25 ? 37  LEU B CD2 1 
ATOM   2448 N  N   . GLN B 1 38  ? -3.651  -8.736  23.594  1.00 11.86 ? 38  GLN B N   1 
ATOM   2449 C  CA  . GLN B 1 38  ? -4.125  -9.197  24.921  1.00 12.34 ? 38  GLN B CA  1 
ATOM   2450 C  C   . GLN B 1 38  ? -5.592  -9.411  24.763  1.00 11.16 ? 38  GLN B C   1 
ATOM   2451 O  O   . GLN B 1 38  ? -6.409  -8.500  24.372  1.00 9.82  ? 38  GLN B O   1 
ATOM   2452 C  CB  . GLN B 1 38  ? -3.895  -8.144  25.933  1.00 15.67 ? 38  GLN B CB  1 
ATOM   2453 C  CG  . GLN B 1 38  ? -4.355  -8.588  27.332  1.00 22.53 ? 38  GLN B CG  1 
ATOM   2454 C  CD  . GLN B 1 38  ? -3.906  -7.581  28.326  1.00 26.86 ? 38  GLN B CD  1 
ATOM   2455 O  OE1 . GLN B 1 38  ? -2.711  -7.373  28.482  1.00 35.78 ? 38  GLN B OE1 1 
ATOM   2456 N  NE2 . GLN B 1 38  ? -4.843  -6.878  28.943  1.00 31.94 ? 38  GLN B NE2 1 
ATOM   2457 N  N   . TYR B 1 39  ? -6.058  -10.580 25.180  1.00 10.78 ? 39  TYR B N   1 
ATOM   2458 C  CA  . TYR B 1 39  ? -7.486  -10.890 25.125  1.00 9.22  ? 39  TYR B CA  1 
ATOM   2459 C  C   . TYR B 1 39  ? -8.278  -10.036 26.068  1.00 9.64  ? 39  TYR B C   1 
ATOM   2460 O  O   . TYR B 1 39  ? -7.844  -9.738  27.201  1.00 12.17 ? 39  TYR B O   1 
ATOM   2461 C  CB  . TYR B 1 39  ? -7.652  -12.377 25.597  1.00 9.61  ? 39  TYR B CB  1 
ATOM   2462 C  CG  . TYR B 1 39  ? -9.097  -12.795 25.745  1.00 9.82  ? 39  TYR B CG  1 
ATOM   2463 C  CD1 . TYR B 1 39  ? -9.993  -12.794 24.701  1.00 10.56 ? 39  TYR B CD1 1 
ATOM   2464 C  CD2 . TYR B 1 39  ? -9.594  -13.166 27.029  1.00 11.67 ? 39  TYR B CD2 1 
ATOM   2465 C  CE1 . TYR B 1 39  ? -11.308 -13.162 24.800  1.00 11.97 ? 39  TYR B CE1 1 
ATOM   2466 C  CE2 . TYR B 1 39  ? -10.924 -13.573 27.137  1.00 12.22 ? 39  TYR B CE2 1 
ATOM   2467 C  CZ  . TYR B 1 39  ? -11.774 -13.594 26.064  1.00 12.28 ? 39  TYR B CZ  1 
ATOM   2468 O  OH  . TYR B 1 39  ? -13.130 -13.948 26.135  1.00 15.08 ? 39  TYR B OH  1 
ATOM   2469 N  N   . ASP B 1 40  ? -9.430  -9.506  25.608  1.00 9.20  ? 40  ASP B N   1 
ATOM   2470 C  CA  . ASP B 1 40  ? -10.319 -8.719  26.480  1.00 10.37 ? 40  ASP B CA  1 
ATOM   2471 C  C   . ASP B 1 40  ? -11.717 -9.240  26.324  1.00 10.66 ? 40  ASP B C   1 
ATOM   2472 O  O   . ASP B 1 40  ? -12.375 -9.010  25.302  1.00 9.87  ? 40  ASP B O   1 
ATOM   2473 C  CB  . ASP B 1 40  ? -10.187 -7.239  26.080  1.00 12.58 ? 40  ASP B CB  1 
ATOM   2474 C  CG  . ASP B 1 40  ? -11.038 -6.332  26.959  1.00 14.95 ? 40  ASP B CG  1 
ATOM   2475 O  OD1 . ASP B 1 40  ? -11.891 -6.818  27.693  1.00 15.47 ? 40  ASP B OD1 1 
ATOM   2476 O  OD2 . ASP B 1 40  ? -10.903 -5.085  26.800  1.00 20.08 ? 40  ASP B OD2 1 
ATOM   2477 N  N   . ALA B 1 41  ? -12.262 -9.961  27.336  1.00 11.11 ? 41  ALA B N   1 
ATOM   2478 C  CA  . ALA B 1 41  ? -13.593 -10.487 27.303  1.00 12.97 ? 41  ALA B CA  1 
ATOM   2479 C  C   . ALA B 1 41  ? -14.717 -9.497  27.209  1.00 12.67 ? 41  ALA B C   1 
ATOM   2480 O  O   . ALA B 1 41  ? -15.825 -9.871  26.830  1.00 14.30 ? 41  ALA B O   1 
ATOM   2481 C  CB  . ALA B 1 41  ? -13.797 -11.375 28.562  1.00 13.38 ? 41  ALA B CB  1 
ATOM   2482 N  N   A SER B 1 42  ? -14.432 -8.228  27.494  0.50 13.69 ? 42  SER B N   1 
ATOM   2483 N  N   B SER B 1 42  ? -14.415 -8.236  27.484  0.50 13.71 ? 42  SER B N   1 
ATOM   2484 C  CA  A SER B 1 42  ? -15.472 -7.182  27.350  0.50 14.05 ? 42  SER B CA  1 
ATOM   2485 C  CA  B SER B 1 42  ? -15.425 -7.177  27.352  0.50 14.16 ? 42  SER B CA  1 
ATOM   2486 C  C   A SER B 1 42  ? -15.784 -6.814  25.899  0.50 13.10 ? 42  SER B C   1 
ATOM   2487 C  C   B SER B 1 42  ? -15.599 -6.644  25.932  0.50 12.62 ? 42  SER B C   1 
ATOM   2488 O  O   A SER B 1 42  ? -16.780 -6.136  25.604  0.50 12.97 ? 42  SER B O   1 
ATOM   2489 O  O   B SER B 1 42  ? -16.320 -5.678  25.699  0.50 12.00 ? 42  SER B O   1 
ATOM   2490 C  CB  A SER B 1 42  ? -15.079 -5.896  28.139  0.50 16.77 ? 42  SER B CB  1 
ATOM   2491 C  CB  B SER B 1 42  ? -15.015 -5.993  28.229  0.50 17.39 ? 42  SER B CB  1 
ATOM   2492 O  OG  A SER B 1 42  ? -14.048 -5.104  27.533  0.50 15.79 ? 42  SER B OG  1 
ATOM   2493 O  OG  B SER B 1 42  ? -14.927 -6.384  29.569  0.50 17.30 ? 42  SER B OG  1 
ATOM   2494 N  N   . LEU B 1 43  ? -14.942 -7.294  24.972  1.00 11.88 ? 43  LEU B N   1 
ATOM   2495 C  CA  . LEU B 1 43  ? -15.126 -6.960  23.520  1.00 10.94 ? 43  LEU B CA  1 
ATOM   2496 C  C   . LEU B 1 43  ? -16.151 -7.875  22.947  1.00 12.54 ? 43  LEU B C   1 
ATOM   2497 O  O   . LEU B 1 43  ? -15.853 -8.919  22.352  1.00 14.38 ? 43  LEU B O   1 
ATOM   2498 C  CB  . LEU B 1 43  ? -13.825 -7.117  22.769  1.00 10.33 ? 43  LEU B CB  1 
ATOM   2499 C  CG  . LEU B 1 43  ? -12.750 -6.122  23.142  1.00 9.00  ? 43  LEU B CG  1 
ATOM   2500 C  CD1 . LEU B 1 43  ? -11.482 -6.430  22.380  1.00 11.42 ? 43  LEU B CD1 1 
ATOM   2501 C  CD2 . LEU B 1 43  ? -13.131 -4.649  22.897  1.00 10.98 ? 43  LEU B CD2 1 
ATOM   2502 N  N   . THR B 1 44  ? -17.390 -7.438  23.114  1.00 15.06 ? 44  THR B N   1 
ATOM   2503 C  CA  . THR B 1 44  ? -18.524 -8.182  22.660  1.00 14.26 ? 44  THR B CA  1 
ATOM   2504 C  C   . THR B 1 44  ? -18.839 -7.884  21.187  1.00 13.45 ? 44  THR B C   1 
ATOM   2505 O  O   . THR B 1 44  ? -18.214 -6.949  20.628  1.00 12.43 ? 44  THR B O   1 
ATOM   2506 C  CB  . THR B 1 44  ? -19.699 -7.876  23.629  1.00 16.18 ? 44  THR B CB  1 
ATOM   2507 O  OG1 . THR B 1 44  ? -19.862 -6.477  23.651  1.00 20.54 ? 44  THR B OG1 1 
ATOM   2508 C  CG2 . THR B 1 44  ? -19.387 -8.399  25.074  1.00 18.07 ? 44  THR B CG2 1 
ATOM   2509 N  N   . PRO B 1 45  ? -19.697 -8.679  20.557  1.00 15.21 ? 45  PRO B N   1 
ATOM   2510 C  CA  . PRO B 1 45  ? -19.914 -8.554  19.113  1.00 15.86 ? 45  PRO B CA  1 
ATOM   2511 C  C   . PRO B 1 45  ? -20.571 -7.264  18.710  1.00 15.75 ? 45  PRO B C   1 
ATOM   2512 O  O   . PRO B 1 45  ? -21.513 -6.761  19.390  1.00 17.84 ? 45  PRO B O   1 
ATOM   2513 C  CB  . PRO B 1 45  ? -20.817 -9.706  18.773  1.00 16.04 ? 45  PRO B CB  1 
ATOM   2514 C  CG  . PRO B 1 45  ? -20.573 -10.755 19.873  1.00 18.90 ? 45  PRO B CG  1 
ATOM   2515 C  CD  . PRO B 1 45  ? -20.380 -9.878  21.081  1.00 16.70 ? 45  PRO B CD  1 
ATOM   2516 N  N   . LEU B 1 46  ? -20.070 -6.672  17.622  1.00 14.64 ? 46  LEU B N   1 
ATOM   2517 C  CA  . LEU B 1 46  ? -20.743 -5.496  17.098  1.00 14.74 ? 46  LEU B CA  1 
ATOM   2518 C  C   . LEU B 1 46  ? -21.979 -5.951  16.355  1.00 13.53 ? 46  LEU B C   1 
ATOM   2519 O  O   . LEU B 1 46  ? -22.083 -7.073  15.860  1.00 13.70 ? 46  LEU B O   1 
ATOM   2520 C  CB  . LEU B 1 46  ? -19.806 -4.761  16.145  1.00 15.02 ? 46  LEU B CB  1 
ATOM   2521 C  CG  . LEU B 1 46  ? -18.553 -4.107  16.748  1.00 18.84 ? 46  LEU B CG  1 
ATOM   2522 C  CD1 . LEU B 1 46  ? -17.670 -3.514  15.610  1.00 19.21 ? 46  LEU B CD1 1 
ATOM   2523 C  CD2 . LEU B 1 46  ? -18.843 -3.015  17.752  1.00 21.73 ? 46  LEU B CD2 1 
ATOM   2524 N  N   . GLU B 1 47  ? -22.972 -5.056  16.328  1.00 14.93 ? 47  GLU B N   1 
ATOM   2525 C  CA  . GLU B 1 47  ? -24.159 -5.255  15.467  1.00 14.82 ? 47  GLU B CA  1 
ATOM   2526 C  C   . GLU B 1 47  ? -24.129 -4.194  14.337  1.00 13.31 ? 47  GLU B C   1 
ATOM   2527 O  O   . GLU B 1 47  ? -23.814 -2.999  14.576  1.00 15.51 ? 47  GLU B O   1 
ATOM   2528 C  CB  . GLU B 1 47  ? -25.459 -5.116  16.292  1.00 21.02 ? 47  GLU B CB  1 
ATOM   2529 C  CG  . GLU B 1 47  ? -25.720 -6.332  17.227  1.00 26.11 ? 47  GLU B CG  1 
ATOM   2530 C  CD  . GLU B 1 47  ? -27.084 -6.266  17.975  1.00 35.69 ? 47  GLU B CD  1 
ATOM   2531 O  OE1 . GLU B 1 47  ? -27.342 -5.277  18.713  1.00 40.65 ? 47  GLU B OE1 1 
ATOM   2532 O  OE2 . GLU B 1 47  ? -27.902 -7.214  17.827  1.00 42.20 ? 47  GLU B OE2 1 
ATOM   2533 N  N   . PHE B 1 48  ? -24.399 -4.674  13.168  1.00 15.05 ? 48  PHE B N   1 
ATOM   2534 C  CA  . PHE B 1 48  ? -24.307 -3.796  11.958  1.00 13.35 ? 48  PHE B CA  1 
ATOM   2535 C  C   . PHE B 1 48  ? -25.699 -3.493  11.518  1.00 14.05 ? 48  PHE B C   1 
ATOM   2536 O  O   . PHE B 1 48  ? -26.447 -4.419  11.140  1.00 20.66 ? 48  PHE B O   1 
ATOM   2537 C  CB  . PHE B 1 48  ? -23.508 -4.479  10.869  1.00 15.57 ? 48  PHE B CB  1 
ATOM   2538 C  CG  . PHE B 1 48  ? -22.208 -4.993  11.376  1.00 13.32 ? 48  PHE B CG  1 
ATOM   2539 C  CD1 . PHE B 1 48  ? -21.139 -4.189  11.575  1.00 13.44 ? 48  PHE B CD1 1 
ATOM   2540 C  CD2 . PHE B 1 48  ? -22.063 -6.362  11.678  1.00 14.62 ? 48  PHE B CD2 1 
ATOM   2541 C  CE1 . PHE B 1 48  ? -19.923 -4.646  12.167  1.00 13.75 ? 48  PHE B CE1 1 
ATOM   2542 C  CE2 . PHE B 1 48  ? -20.831 -6.813  12.185  1.00 15.01 ? 48  PHE B CE2 1 
ATOM   2543 C  CZ  . PHE B 1 48  ? -19.768 -5.962  12.440  1.00 14.45 ? 48  PHE B CZ  1 
ATOM   2544 N  N   . GLN B 1 49  ? -26.089 -2.214  11.702  1.00 13.51 ? 49  GLN B N   1 
ATOM   2545 C  CA  . GLN B 1 49  ? -27.517 -1.869  11.469  1.00 15.38 ? 49  GLN B CA  1 
ATOM   2546 C  C   . GLN B 1 49  ? -27.708 -0.974  10.266  1.00 12.96 ? 49  GLN B C   1 
ATOM   2547 O  O   . GLN B 1 49  ? -26.908 -0.087  10.057  1.00 13.52 ? 49  GLN B O   1 
ATOM   2548 C  CB  . GLN B 1 49  ? -28.131 -1.166  12.686  1.00 15.17 ? 49  GLN B CB  1 
ATOM   2549 C  CG  . GLN B 1 49  ? -27.936 -2.163  13.831  1.00 22.85 ? 49  GLN B CG  1 
ATOM   2550 C  CD  . GLN B 1 49  ? -29.153 -2.436  14.625  1.00 35.44 ? 49  GLN B CD  1 
ATOM   2551 O  OE1 . GLN B 1 49  ? -29.251 -1.972  15.772  1.00 45.66 ? 49  GLN B OE1 1 
ATOM   2552 N  NE2 . GLN B 1 49  ? -30.100 -3.216  14.043  1.00 34.94 ? 49  GLN B NE2 1 
ATOM   2553 N  N   . GLY B 1 50  ? -28.677 -1.305  9.427   1.00 14.04 ? 50  GLY B N   1 
ATOM   2554 C  CA  . GLY B 1 50  ? -28.910 -0.478  8.289   1.00 12.47 ? 50  GLY B CA  1 
ATOM   2555 C  C   . GLY B 1 50  ? -27.822 -0.656  7.241   1.00 13.05 ? 50  GLY B C   1 
ATOM   2556 O  O   . GLY B 1 50  ? -27.704 0.173   6.357   1.00 13.22 ? 50  GLY B O   1 
ATOM   2557 N  N   . TYR B 1 51  ? -27.041 -1.736  7.370   1.00 11.17 ? 51  TYR B N   1 
ATOM   2558 C  CA  . TYR B 1 51  ? -26.089 -2.095  6.263   1.00 9.69  ? 51  TYR B CA  1 
ATOM   2559 C  C   . TYR B 1 51  ? -26.682 -2.557  4.965   1.00 10.50 ? 51  TYR B C   1 
ATOM   2560 O  O   . TYR B 1 51  ? -26.055 -2.578  3.933   1.00 10.14 ? 51  TYR B O   1 
ATOM   2561 C  CB  . TYR B 1 51  ? -25.067 -3.154  6.793   1.00 10.07 ? 51  TYR B CB  1 
ATOM   2562 C  CG  . TYR B 1 51  ? -23.886 -2.564  7.527   1.00 9.53  ? 51  TYR B CG  1 
ATOM   2563 C  CD1 . TYR B 1 51  ? -22.601 -3.047  7.229   1.00 9.33  ? 51  TYR B CD1 1 
ATOM   2564 C  CD2 . TYR B 1 51  ? -24.020 -1.607  8.520   1.00 9.19  ? 51  TYR B CD2 1 
ATOM   2565 C  CE1 . TYR B 1 51  ? -21.521 -2.488  7.917   1.00 9.08  ? 51  TYR B CE1 1 
ATOM   2566 C  CE2 . TYR B 1 51  ? -22.947 -1.018  9.224   1.00 9.90  ? 51  TYR B CE2 1 
ATOM   2567 C  CZ  . TYR B 1 51  ? -21.663 -1.490  8.901   1.00 9.27  ? 51  TYR B CZ  1 
ATOM   2568 O  OH  . TYR B 1 51  ? -20.497 -0.939  9.452   1.00 9.82  ? 51  TYR B OH  1 
ATOM   2569 N  N   . ASN B 1 52  ? -27.962 -3.009  5.034   1.00 12.48 ? 52  ASN B N   1 
ATOM   2570 C  CA  . ASN B 1 52  ? -28.584 -3.581  3.858   1.00 11.90 ? 52  ASN B CA  1 
ATOM   2571 C  C   . ASN B 1 52  ? -29.197 -2.456  3.051   1.00 13.40 ? 52  ASN B C   1 
ATOM   2572 O  O   . ASN B 1 52  ? -30.360 -2.119  3.200   1.00 14.42 ? 52  ASN B O   1 
ATOM   2573 C  CB  . ASN B 1 52  ? -29.684 -4.593  4.272   1.00 14.95 ? 52  ASN B CB  1 
ATOM   2574 C  CG  . ASN B 1 52  ? -30.241 -5.334  3.104   1.00 19.36 ? 52  ASN B CG  1 
ATOM   2575 O  OD1 . ASN B 1 52  ? -29.841 -5.160  1.943   1.00 21.29 ? 52  ASN B OD1 1 
ATOM   2576 N  ND2 . ASN B 1 52  ? -31.264 -6.166  3.400   1.00 24.54 ? 52  ASN B ND2 1 
ATOM   2577 N  N   . LEU B 1 53  ? -28.389 -1.778  2.277   1.00 10.76 ? 53  LEU B N   1 
ATOM   2578 C  CA  . LEU B 1 53  ? -28.821 -0.579  1.564   1.00 10.59 ? 53  LEU B CA  1 
ATOM   2579 C  C   . LEU B 1 53  ? -29.792 -0.991  0.386   1.00 9.62  ? 53  LEU B C   1 
ATOM   2580 O  O   . LEU B 1 53  ? -29.566 -1.952  -0.315  1.00 11.91 ? 53  LEU B O   1 
ATOM   2581 C  CB  . LEU B 1 53  ? -27.597 0.090   0.920   1.00 11.26 ? 53  LEU B CB  1 
ATOM   2582 C  CG  . LEU B 1 53  ? -26.536 0.471   1.932   1.00 12.10 ? 53  LEU B CG  1 
ATOM   2583 C  CD1 . LEU B 1 53  ? -25.500 1.186   1.079   1.00 14.91 ? 53  LEU B CD1 1 
ATOM   2584 C  CD2 . LEU B 1 53  ? -27.076 1.349   3.033   1.00 12.99 ? 53  LEU B CD2 1 
ATOM   2585 N  N   . SER B 1 54  ? -30.861 -0.198  0.225   1.00 10.58 ? 54  SER B N   1 
ATOM   2586 C  CA  . SER B 1 54  ? -31.802 -0.533  -0.823  1.00 10.91 ? 54  SER B CA  1 
ATOM   2587 C  C   . SER B 1 54  ? -31.161 -0.554  -2.238  1.00 11.10 ? 54  SER B C   1 
ATOM   2588 O  O   . SER B 1 54  ? -30.516 0.449   -2.604  1.00 10.73 ? 54  SER B O   1 
ATOM   2589 C  CB  . SER B 1 54  ? -32.925 0.437   -0.780  1.00 12.98 ? 54  SER B CB  1 
ATOM   2590 O  OG  . SER B 1 54  ? -33.797 0.113   -1.868  1.00 13.58 ? 54  SER B OG  1 
ATOM   2591 N  N   . ALA B 1 55  ? -31.401 -1.621  -2.989  1.00 11.96 ? 55  ALA B N   1 
ATOM   2592 C  CA  . ALA B 1 55  ? -30.942 -1.744  -4.376  1.00 13.18 ? 55  ALA B CA  1 
ATOM   2593 C  C   . ALA B 1 55  ? -31.649 -0.737  -5.268  1.00 12.59 ? 55  ALA B C   1 
ATOM   2594 O  O   . ALA B 1 55  ? -31.227 -0.552  -6.415  1.00 15.13 ? 55  ALA B O   1 
ATOM   2595 C  CB  . ALA B 1 55  ? -31.033 -3.181  -4.926  1.00 18.14 ? 55  ALA B CB  1 
ATOM   2596 N  N   . ASN B 1 56  ? -32.687 -0.061  -4.782  1.00 12.61 ? 56  ASN B N   1 
ATOM   2597 C  CA  . ASN B 1 56  ? -33.352 0.928   -5.625  1.00 13.63 ? 56  ASN B CA  1 
ATOM   2598 C  C   . ASN B 1 56  ? -32.836 2.325   -5.394  1.00 12.20 ? 56  ASN B C   1 
ATOM   2599 O  O   . ASN B 1 56  ? -33.154 3.267   -6.140  1.00 14.99 ? 56  ASN B O   1 
ATOM   2600 C  CB  . ASN B 1 56  ? -34.870 0.910   -5.460  1.00 14.60 ? 56  ASN B CB  1 
ATOM   2601 C  CG  . ASN B 1 56  ? -35.493 -0.414  -5.864  1.00 20.21 ? 56  ASN B CG  1 
ATOM   2602 O  OD1 . ASN B 1 56  ? -34.943 -1.254  -6.599  1.00 19.05 ? 56  ASN B OD1 1 
ATOM   2603 N  ND2 . ASN B 1 56  ? -36.717 -0.596  -5.376  1.00 23.41 ? 56  ASN B ND2 1 
ATOM   2604 N  N   . LYS B 1 57  ? -31.984 2.458   -4.399  1.00 10.96 ? 57  LYS B N   1 
ATOM   2605 C  CA  . LYS B 1 57  ? -31.249 3.638   -4.092  1.00 10.65 ? 57  LYS B CA  1 
ATOM   2606 C  C   . LYS B 1 57  ? -29.808 3.537   -4.660  1.00 9.05  ? 57  LYS B C   1 
ATOM   2607 O  O   . LYS B 1 57  ? -29.385 2.432   -5.136  1.00 10.15 ? 57  LYS B O   1 
ATOM   2608 C  CB  . LYS B 1 57  ? -31.185 3.921   -2.578  1.00 11.59 ? 57  LYS B CB  1 
ATOM   2609 C  CG  . LYS B 1 57  ? -32.502 4.418   -1.976  1.00 13.12 ? 57  LYS B CG  1 
ATOM   2610 C  CD  . LYS B 1 57  ? -32.369 4.511   -0.466  1.00 17.16 ? 57  LYS B CD  1 
ATOM   2611 C  CE  . LYS B 1 57  ? -33.658 5.095   0.042   1.00 23.29 ? 57  LYS B CE  1 
ATOM   2612 N  NZ  . LYS B 1 57  ? -33.412 5.896   1.282   1.00 28.77 ? 57  LYS B NZ  1 
ATOM   2613 N  N   . GLN B 1 58  ? -29.170 4.707   -4.775  1.00 9.56  ? 58  GLN B N   1 
ATOM   2614 C  CA  . GLN B 1 58  ? -27.817 4.740   -5.349  1.00 9.19  ? 58  GLN B CA  1 
ATOM   2615 C  C   . GLN B 1 58  ? -26.976 5.674   -4.493  1.00 8.62  ? 58  GLN B C   1 
ATOM   2616 O  O   . GLN B 1 58  ? -27.378 6.619   -3.838  1.00 10.24 ? 58  GLN B O   1 
ATOM   2617 C  CB  . GLN B 1 58  ? -27.753 5.035   -6.832  1.00 13.43 ? 58  GLN B CB  1 
ATOM   2618 C  CG  . GLN B 1 58  ? -28.198 6.409   -7.154  1.00 15.24 ? 58  GLN B CG  1 
ATOM   2619 C  CD  . GLN B 1 58  ? -28.641 6.458   -8.677  1.00 15.01 ? 58  GLN B CD  1 
ATOM   2620 O  OE1 . GLN B 1 58  ? -28.420 5.522   -9.514  1.00 18.33 ? 58  GLN B OE1 1 
ATOM   2621 N  NE2 . GLN B 1 58  ? -29.365 7.514   -8.969  1.00 20.24 ? 58  GLN B NE2 1 
ATOM   2622 N  N   . PHE B 1 59  ? -25.693 5.275   -4.438  1.00 8.42  ? 59  PHE B N   1 
ATOM   2623 C  CA  . PHE B 1 59  ? -24.689 5.923   -3.530  1.00 7.92  ? 59  PHE B CA  1 
ATOM   2624 C  C   . PHE B 1 59  ? -23.480 6.331   -4.325  1.00 7.97  ? 59  PHE B C   1 
ATOM   2625 O  O   . PHE B 1 59  ? -23.043 5.647   -5.244  1.00 8.21  ? 59  PHE B O   1 
ATOM   2626 C  CB  . PHE B 1 59  ? -24.323 4.799   -2.512  1.00 8.06  ? 59  PHE B CB  1 
ATOM   2627 C  CG  . PHE B 1 59  ? -25.568 4.420   -1.685  1.00 8.05  ? 59  PHE B CG  1 
ATOM   2628 C  CD1 . PHE B 1 59  ? -26.414 3.387   -2.161  1.00 9.19  ? 59  PHE B CD1 1 
ATOM   2629 C  CD2 . PHE B 1 59  ? -25.898 5.196   -0.560  1.00 8.62  ? 59  PHE B CD2 1 
ATOM   2630 C  CE1 . PHE B 1 59  ? -27.658 3.178   -1.451  1.00 9.71  ? 59  PHE B CE1 1 
ATOM   2631 C  CE2 . PHE B 1 59  ? -27.098 4.960   0.110   1.00 10.09 ? 59  PHE B CE2 1 
ATOM   2632 C  CZ  . PHE B 1 59  ? -27.916 3.927   -0.338  1.00 10.30 ? 59  PHE B CZ  1 
ATOM   2633 N  N   . LEU B 1 60  ? -22.993 7.490   -3.960  1.00 7.79  ? 60  LEU B N   1 
ATOM   2634 C  CA  . LEU B 1 60  ? -21.944 8.132   -4.779  1.00 8.90  ? 60  LEU B CA  1 
ATOM   2635 C  C   . LEU B 1 60  ? -20.564 7.565   -4.521  1.00 8.43  ? 60  LEU B C   1 
ATOM   2636 O  O   . LEU B 1 60  ? -20.082 7.580   -3.381  1.00 8.83  ? 60  LEU B O   1 
ATOM   2637 C  CB  . LEU B 1 60  ? -21.949 9.601   -4.382  1.00 11.92 ? 60  LEU B CB  1 
ATOM   2638 C  CG  . LEU B 1 60  ? -21.124 10.510  -5.286  1.00 14.99 ? 60  LEU B CG  1 
ATOM   2639 C  CD1 . LEU B 1 60  ? -21.830 10.674  -6.612  1.00 16.87 ? 60  LEU B CD1 1 
ATOM   2640 C  CD2 . LEU B 1 60  ? -20.980 11.871  -4.586  1.00 18.38 ? 60  LEU B CD2 1 
ATOM   2641 N  N   . LEU B 1 61  ? -19.945 7.145   -5.556  1.00 8.49  ? 61  LEU B N   1 
ATOM   2642 C  CA  . LEU B 1 61  ? -18.527 6.669   -5.625  1.00 8.24  ? 61  LEU B CA  1 
ATOM   2643 C  C   . LEU B 1 61  ? -17.687 7.820   -6.139  1.00 9.31  ? 61  LEU B C   1 
ATOM   2644 O  O   . LEU B 1 61  ? -18.024 8.363   -7.184  1.00 11.95 ? 61  LEU B O   1 
ATOM   2645 C  CB  . LEU B 1 61  ? -18.496 5.417   -6.508  1.00 9.45  ? 61  LEU B CB  1 
ATOM   2646 C  CG  . LEU B 1 61  ? -17.162 4.719   -6.572  1.00 9.77  ? 61  LEU B CG  1 
ATOM   2647 C  CD1 . LEU B 1 61  ? -16.943 3.908   -5.269  1.00 10.56 ? 61  LEU B CD1 1 
ATOM   2648 C  CD2 . LEU B 1 61  ? -17.161 3.673   -7.700  1.00 11.50 ? 61  LEU B CD2 1 
ATOM   2649 N  N   . THR B 1 62  ? -16.628 8.190   -5.445  1.00 10.18 ? 62  THR B N   1 
ATOM   2650 C  CA  . THR B 1 62  ? -15.863 9.396   -5.893  1.00 9.72  ? 62  THR B CA  1 
ATOM   2651 C  C   . THR B 1 62  ? -14.358 9.104   -5.845  1.00 11.22 ? 62  THR B C   1 
ATOM   2652 O  O   . THR B 1 62  ? -13.857 8.556   -4.850  1.00 12.00 ? 62  THR B O   1 
ATOM   2653 C  CB  . THR B 1 62  ? -16.000 10.566  -4.932  1.00 14.87 ? 62  THR B CB  1 
ATOM   2654 O  OG1 . THR B 1 62  ? -17.378 10.934  -4.863  1.00 18.52 ? 62  THR B OG1 1 
ATOM   2655 C  CG2 . THR B 1 62  ? -15.084 11.787  -5.366  1.00 18.40 ? 62  THR B CG2 1 
ATOM   2656 N  N   . ASN B 1 63  ? -13.617 9.507   -6.870  1.00 9.51  ? 63  ASN B N   1 
ATOM   2657 C  CA  . ASN B 1 63  ? -12.138 9.497   -6.817  1.00 9.99  ? 63  ASN B CA  1 
ATOM   2658 C  C   . ASN B 1 63  ? -11.697 10.901  -6.453  1.00 9.60  ? 63  ASN B C   1 
ATOM   2659 O  O   . ASN B 1 63  ? -11.903 11.836  -7.098  1.00 11.14 ? 63  ASN B O   1 
ATOM   2660 C  CB  . ASN B 1 63  ? -11.644 9.141   -8.259  1.00 9.32  ? 63  ASN B CB  1 
ATOM   2661 C  CG  . ASN B 1 63  ? -10.119 9.035   -8.340  1.00 8.31  ? 63  ASN B CG  1 
ATOM   2662 O  OD1 . ASN B 1 63  ? -9.422  9.660   -7.505  1.00 8.98  ? 63  ASN B OD1 1 
ATOM   2663 N  ND2 . ASN B 1 63  ? -9.616  8.376   -9.373  1.00 7.42  ? 63  ASN B ND2 1 
ATOM   2664 N  N   . ASN B 1 64  ? -11.111 11.087  -5.219  1.00 12.71 ? 64  ASN B N   1 
ATOM   2665 C  CA  . ASN B 1 64  ? -10.636 12.417  -4.776  1.00 14.91 ? 64  ASN B CA  1 
ATOM   2666 C  C   . ASN B 1 64  ? -9.135  12.569  -4.982  1.00 17.05 ? 64  ASN B C   1 
ATOM   2667 O  O   . ASN B 1 64  ? -8.573  13.569  -4.501  1.00 18.81 ? 64  ASN B O   1 
ATOM   2668 C  CB  . ASN B 1 64  ? -10.942 12.716  -3.300  1.00 18.43 ? 64  ASN B CB  1 
ATOM   2669 C  CG  . ASN B 1 64  ? -10.257 11.743  -2.353  1.00 20.29 ? 64  ASN B CG  1 
ATOM   2670 O  OD1 . ASN B 1 64  ? -9.205  11.153  -2.659  1.00 19.98 ? 64  ASN B OD1 1 
ATOM   2671 N  ND2 . ASN B 1 64  ? -10.836 11.591  -1.096  1.00 22.03 ? 64  ASN B ND2 1 
ATOM   2672 N  N   . GLY B 1 65  ? -8.521  11.616  -5.716  1.00 14.60 ? 65  GLY B N   1 
ATOM   2673 C  CA  . GLY B 1 65  ? -7.122  11.821  -6.058  1.00 15.49 ? 65  GLY B CA  1 
ATOM   2674 C  C   . GLY B 1 65  ? -6.215  11.082  -5.141  1.00 15.52 ? 65  GLY B C   1 
ATOM   2675 O  O   . GLY B 1 65  ? -4.978  10.797  -5.448  1.00 16.85 ? 65  GLY B O   1 
ATOM   2676 N  N   . HIS B 1 66  ? -6.689  10.777  -3.940  1.00 16.79 ? 66  HIS B N   1 
ATOM   2677 C  CA  . HIS B 1 66  ? -5.792  10.039  -3.075  1.00 15.43 ? 66  HIS B CA  1 
ATOM   2678 C  C   . HIS B 1 66  ? -6.456  8.759   -2.837  1.00 16.82 ? 66  HIS B C   1 
ATOM   2679 O  O   . HIS B 1 66  ? -5.873  7.799   -2.522  1.00 15.96 ? 66  HIS B O   1 
ATOM   2680 C  CB  . HIS B 1 66  ? -5.679  10.749  -1.708  1.00 13.03 ? 66  HIS B CB  1 
ATOM   2681 C  CG  . HIS B 1 66  ? -4.962  12.024  -1.762  1.00 14.11 ? 66  HIS B CG  1 
ATOM   2682 N  ND1 . HIS B 1 66  ? -3.634  12.086  -2.056  1.00 14.02 ? 66  HIS B ND1 1 
ATOM   2683 C  CD2 . HIS B 1 66  ? -5.358  13.281  -1.589  1.00 14.21 ? 66  HIS B CD2 1 
ATOM   2684 C  CE1 . HIS B 1 66  ? -3.244  13.365  -2.051  1.00 14.88 ? 66  HIS B CE1 1 
ATOM   2685 N  NE2 . HIS B 1 66  ? -4.304  14.101  -1.779  1.00 19.11 ? 66  HIS B NE2 1 
ATOM   2686 N  N   . SER B 1 67  ? -7.800  8.711   -2.990  1.00 17.92 ? 67  SER B N   1 
ATOM   2687 C  CA  . SER B 1 67  ? -8.442  7.474   -2.756  1.00 16.60 ? 67  SER B CA  1 
ATOM   2688 C  C   . SER B 1 67  ? -9.742  7.465   -3.589  1.00 17.59 ? 67  SER B C   1 
ATOM   2689 O  O   . SER B 1 67  ? -10.192 8.579   -4.085  1.00 19.76 ? 67  SER B O   1 
ATOM   2690 C  CB  . SER B 1 67  ? -8.762  7.307   -1.269  1.00 15.77 ? 67  SER B CB  1 
ATOM   2691 O  OG  . SER B 1 67  ? -9.780  6.342   -1.061  1.00 20.22 ? 67  SER B OG  1 
ATOM   2692 N  N   . VAL B 1 68  ? -10.322 6.277   -3.711  1.00 16.06 ? 68  VAL B N   1 
ATOM   2693 C  CA  . VAL B 1 68  ? -11.750 6.184   -4.147  1.00 13.61 ? 68  VAL B CA  1 
ATOM   2694 C  C   . VAL B 1 68  ? -12.682 5.697   -3.019  1.00 10.64 ? 68  VAL B C   1 
ATOM   2695 O  O   . VAL B 1 68  ? -12.465 4.647   -2.403  1.00 11.50 ? 68  VAL B O   1 
ATOM   2696 C  CB  . VAL B 1 68  ? -11.916 5.202   -5.320  1.00 14.90 ? 68  VAL B CB  1 
ATOM   2697 C  CG1 . VAL B 1 68  ? -11.539 3.754   -5.069  1.00 20.82 ? 68  VAL B CG1 1 
ATOM   2698 C  CG2 . VAL B 1 68  ? -13.371 5.249   -5.816  1.00 15.20 ? 68  VAL B CG2 1 
ATOM   2699 N  N   . LYS B 1 69  ? -13.654 6.552   -2.772  1.00 9.80  ? 69  LYS B N   1 
ATOM   2700 C  CA  . LYS B 1 69  ? -14.573 6.262   -1.639  1.00 9.31  ? 69  LYS B CA  1 
ATOM   2701 C  C   . LYS B 1 69  ? -16.005 6.096   -2.122  1.00 8.10  ? 69  LYS B C   1 
ATOM   2702 O  O   . LYS B 1 69  ? -16.464 6.766   -3.065  1.00 8.62  ? 69  LYS B O   1 
ATOM   2703 C  CB  . LYS B 1 69  ? -14.429 7.309   -0.567  1.00 13.44 ? 69  LYS B CB  1 
ATOM   2704 C  CG  . LYS B 1 69  ? -14.997 8.664   -0.979  1.00 16.57 ? 69  LYS B CG  1 
ATOM   2705 C  CD  . LYS B 1 69  ? -14.716 9.770   0.027   1.00 21.07 ? 69  LYS B CD  1 
ATOM   2706 C  CE  . LYS B 1 69  ? -15.417 11.090  -0.313  1.00 26.93 ? 69  LYS B CE  1 
ATOM   2707 N  NZ  . LYS B 1 69  ? -15.912 11.726  0.972   1.00 30.55 ? 69  LYS B NZ  1 
ATOM   2708 N  N   . LEU B 1 70  ? -16.776 5.267   -1.434  1.00 6.08  ? 70  LEU B N   1 
ATOM   2709 C  CA  . LEU B 1 70  ? -18.235 5.164   -1.620  1.00 6.69  ? 70  LEU B CA  1 
ATOM   2710 C  C   . LEU B 1 70  ? -18.848 5.863   -0.429  1.00 6.64  ? 70  LEU B C   1 
ATOM   2711 O  O   . LEU B 1 70  ? -18.636 5.435   0.725   1.00 6.97  ? 70  LEU B O   1 
ATOM   2712 C  CB  . LEU B 1 70  ? -18.592 3.690   -1.699  1.00 7.38  ? 70  LEU B CB  1 
ATOM   2713 C  CG  . LEU B 1 70  ? -20.099 3.370   -1.829  1.00 7.54  ? 70  LEU B CG  1 
ATOM   2714 C  CD1 . LEU B 1 70  ? -20.571 3.893   -3.154  1.00 8.69  ? 70  LEU B CD1 1 
ATOM   2715 C  CD2 . LEU B 1 70  ? -20.348 1.908   -1.651  1.00 9.02  ? 70  LEU B CD2 1 
ATOM   2716 N  N   . ASN B 1 71  ? -19.671 6.879   -0.650  1.00 7.88  ? 71  ASN B N   1 
ATOM   2717 C  CA  . ASN B 1 71  ? -20.429 7.558   0.426   1.00 9.02  ? 71  ASN B CA  1 
ATOM   2718 C  C   . ASN B 1 71  ? -21.525 6.608   0.915   1.00 8.50  ? 71  ASN B C   1 
ATOM   2719 O  O   . ASN B 1 71  ? -22.154 5.869   0.137   1.00 10.77 ? 71  ASN B O   1 
ATOM   2720 C  CB  . ASN B 1 71  ? -21.024 8.846   -0.186  1.00 11.01 ? 71  ASN B CB  1 
ATOM   2721 C  CG  . ASN B 1 71  ? -20.020 9.993   -0.248  1.00 15.84 ? 71  ASN B CG  1 
ATOM   2722 O  OD1 . ASN B 1 71  ? -18.858 9.885   0.117   1.00 20.43 ? 71  ASN B OD1 1 
ATOM   2723 N  ND2 . ASN B 1 71  ? -20.559 11.226  -0.599  1.00 21.09 ? 71  ASN B ND2 1 
ATOM   2724 N  N   . LEU B 1 72  ? -21.647 6.632   2.252   1.00 7.98  ? 72  LEU B N   1 
ATOM   2725 C  CA  . LEU B 1 72  ? -22.631 5.768   2.900   1.00 8.53  ? 72  LEU B CA  1 
ATOM   2726 C  C   . LEU B 1 72  ? -23.601 6.631   3.725   1.00 9.57  ? 72  LEU B C   1 
ATOM   2727 O  O   . LEU B 1 72  ? -23.221 7.746   4.163   1.00 9.39  ? 72  LEU B O   1 
ATOM   2728 C  CB  . LEU B 1 72  ? -21.841 4.839   3.858   1.00 7.48  ? 72  LEU B CB  1 
ATOM   2729 C  CG  . LEU B 1 72  ? -20.967 3.800   3.144   1.00 7.37  ? 72  LEU B CG  1 
ATOM   2730 C  CD1 . LEU B 1 72  ? -20.092 3.168   4.260   1.00 7.04  ? 72  LEU B CD1 1 
ATOM   2731 C  CD2 . LEU B 1 72  ? -21.755 2.827   2.316   1.00 8.65  ? 72  LEU B CD2 1 
ATOM   2732 N  N   . PRO B 1 73  ? -24.836 6.127   3.936   1.00 9.08  ? 73  PRO B N   1 
ATOM   2733 C  CA  . PRO B 1 73  ? -25.879 6.950   4.588   1.00 10.97 ? 73  PRO B CA  1 
ATOM   2734 C  C   . PRO B 1 73  ? -25.766 6.917   6.108   1.00 13.37 ? 73  PRO B C   1 
ATOM   2735 O  O   . PRO B 1 73  ? -25.254 5.923   6.669   1.00 14.00 ? 73  PRO B O   1 
ATOM   2736 C  CB  . PRO B 1 73  ? -27.113 6.251   4.149   1.00 11.27 ? 73  PRO B CB  1 
ATOM   2737 C  CG  . PRO B 1 73  ? -26.717 4.778   3.996   1.00 9.93  ? 73  PRO B CG  1 
ATOM   2738 C  CD  . PRO B 1 73  ? -25.365 4.878   3.344   1.00 9.51  ? 73  PRO B CD  1 
ATOM   2739 N  N   . SER B 1 74  ? -26.150 8.016   6.751   1.00 17.75 ? 74  SER B N   1 
ATOM   2740 C  CA  . SER B 1 74  ? -25.986 8.031   8.222   1.00 17.81 ? 74  SER B CA  1 
ATOM   2741 C  C   . SER B 1 74  ? -27.006 7.106   8.934   1.00 18.59 ? 74  SER B C   1 
ATOM   2742 O  O   . SER B 1 74  ? -26.795 6.853   10.126  1.00 20.45 ? 74  SER B O   1 
ATOM   2743 C  CB  . SER B 1 74  ? -26.113 9.453   8.776   1.00 22.03 ? 74  SER B CB  1 
ATOM   2744 O  OG  . SER B 1 74  ? -27.389 9.919   8.386   1.00 24.14 ? 74  SER B OG  1 
ATOM   2745 N  N   . ASP B 1 75  ? -27.999 6.565   8.233   1.00 19.11 ? 75  ASP B N   1 
ATOM   2746 C  CA  . ASP B 1 75  ? -28.844 5.519   8.846   1.00 21.57 ? 75  ASP B CA  1 
ATOM   2747 C  C   . ASP B 1 75  ? -28.152 4.173   9.033   1.00 18.87 ? 75  ASP B C   1 
ATOM   2748 O  O   . ASP B 1 75  ? -28.672 3.277   9.738   1.00 18.86 ? 75  ASP B O   1 
ATOM   2749 C  CB  . ASP B 1 75  ? -30.251 5.387   8.222   1.00 25.60 ? 75  ASP B CB  1 
ATOM   2750 C  CG  . ASP B 1 75  ? -30.268 5.128   6.722   1.00 34.96 ? 75  ASP B CG  1 
ATOM   2751 O  OD1 . ASP B 1 75  ? -29.261 4.766   6.107   1.00 38.27 ? 75  ASP B OD1 1 
ATOM   2752 O  OD2 . ASP B 1 75  ? -31.361 5.289   6.114   1.00 44.76 ? 75  ASP B OD2 1 
ATOM   2753 N  N   . MET B 1 76  ? -26.981 4.023   8.426   1.00 14.17 ? 76  MET B N   1 
ATOM   2754 C  CA  . MET B 1 76  ? -26.165 2.826   8.621   1.00 13.08 ? 76  MET B CA  1 
ATOM   2755 C  C   . MET B 1 76  ? -25.293 3.045   9.866   1.00 11.87 ? 76  MET B C   1 
ATOM   2756 O  O   . MET B 1 76  ? -24.590 4.046   9.991   1.00 11.29 ? 76  MET B O   1 
ATOM   2757 C  CB  . MET B 1 76  ? -25.347 2.737   7.347   1.00 14.64 ? 76  MET B CB  1 
ATOM   2758 C  CG  . MET B 1 76  ? -24.385 1.653   7.367   1.00 13.81 ? 76  MET B CG  1 
ATOM   2759 S  SD  . MET B 1 76  ? -23.724 1.540   5.616   1.00 13.95 ? 76  MET B SD  1 
ATOM   2760 C  CE  . MET B 1 76  ? -22.332 0.571   6.123   1.00 11.87 ? 76  MET B CE  1 
ATOM   2761 N  N   A HIS B 1 77  ? -25.360 2.105   10.805  0.50 12.15 ? 77  HIS B N   1 
ATOM   2762 N  N   B HIS B 1 77  ? -25.314 2.144   10.840  0.50 12.01 ? 77  HIS B N   1 
ATOM   2763 C  CA  A HIS B 1 77  ? -24.830 2.333   12.128  0.50 12.31 ? 77  HIS B CA  1 
ATOM   2764 C  CA  B HIS B 1 77  ? -24.518 2.394   12.019  0.50 12.22 ? 77  HIS B CA  1 
ATOM   2765 C  C   A HIS B 1 77  ? -24.054 1.153   12.684  0.50 11.86 ? 77  HIS B C   1 
ATOM   2766 C  C   B HIS B 1 77  ? -24.092 1.171   12.732  0.50 11.64 ? 77  HIS B C   1 
ATOM   2767 O  O   A HIS B 1 77  ? -24.266 0.060   12.219  0.50 12.01 ? 77  HIS B O   1 
ATOM   2768 O  O   B HIS B 1 77  ? -24.627 0.080   12.485  0.50 12.23 ? 77  HIS B O   1 
ATOM   2769 C  CB  A HIS B 1 77  ? -25.957 2.670   13.180  0.50 14.25 ? 77  HIS B CB  1 
ATOM   2770 C  CB  B HIS B 1 77  ? -25.240 3.297   13.048  0.50 13.74 ? 77  HIS B CB  1 
ATOM   2771 C  CG  A HIS B 1 77  ? -26.845 3.899   12.870  0.50 15.39 ? 77  HIS B CG  1 
ATOM   2772 C  CG  B HIS B 1 77  ? -26.557 2.746   13.508  0.50 16.63 ? 77  HIS B CG  1 
ATOM   2773 N  ND1 A HIS B 1 77  ? -26.435 5.176   13.014  0.50 17.69 ? 77  HIS B ND1 1 
ATOM   2774 N  ND1 B HIS B 1 77  ? -27.677 2.834   12.783  0.50 16.85 ? 77  HIS B ND1 1 
ATOM   2775 C  CD2 A HIS B 1 77  ? -28.182 3.977   12.457  0.50 16.02 ? 77  HIS B CD2 1 
ATOM   2776 C  CD2 B HIS B 1 77  ? -26.899 2.095   14.676  0.50 17.72 ? 77  HIS B CD2 1 
ATOM   2777 C  CE1 A HIS B 1 77  ? -27.466 6.035   12.710  0.50 16.38 ? 77  HIS B CE1 1 
ATOM   2778 C  CE1 B HIS B 1 77  ? -28.700 2.282   13.455  0.50 16.31 ? 77  HIS B CE1 1 
ATOM   2779 N  NE2 A HIS B 1 77  ? -28.510 5.306   12.353  0.50 18.33 ? 77  HIS B NE2 1 
ATOM   2780 N  NE2 B HIS B 1 77  ? -28.235 1.835   14.619  0.50 18.54 ? 77  HIS B NE2 1 
ATOM   2781 N  N   . ILE B 1 78  ? -23.110 1.365   13.579  1.00 12.08 ? 78  ILE B N   1 
ATOM   2782 C  CA  . ILE B 1 78  ? -22.696 0.198   14.357  1.00 14.85 ? 78  ILE B CA  1 
ATOM   2783 C  C   . ILE B 1 78  ? -23.195 0.359   15.773  1.00 17.20 ? 78  ILE B C   1 
ATOM   2784 O  O   . ILE B 1 78  ? -23.149 1.470   16.313  1.00 16.58 ? 78  ILE B O   1 
ATOM   2785 C  CB  . ILE B 1 78  ? -21.186 -0.142  14.270  1.00 18.51 ? 78  ILE B CB  1 
ATOM   2786 C  CG1 . ILE B 1 78  ? -20.297 1.044   14.436  1.00 20.13 ? 78  ILE B CG1 1 
ATOM   2787 C  CG2 . ILE B 1 78  ? -20.777 -0.786  12.946  1.00 23.29 ? 78  ILE B CG2 1 
ATOM   2788 C  CD1 . ILE B 1 78  ? -18.855 0.702   14.001  1.00 18.71 ? 78  ILE B CD1 1 
ATOM   2789 N  N   . GLN B 1 79  ? -23.722 -0.743  16.299  1.00 17.04 ? 79  GLN B N   1 
ATOM   2790 C  CA  . GLN B 1 79  ? -24.220 -0.789  17.689  1.00 19.33 ? 79  GLN B CA  1 
ATOM   2791 C  C   . GLN B 1 79  ? -23.201 -1.659  18.482  1.00 19.35 ? 79  GLN B C   1 
ATOM   2792 O  O   . GLN B 1 79  ? -22.755 -2.726  18.070  1.00 17.91 ? 79  GLN B O   1 
ATOM   2793 C  CB  . GLN B 1 79  ? -25.629 -1.419  17.708  1.00 23.53 ? 79  GLN B CB  1 
ATOM   2794 C  CG  . GLN B 1 79  ? -26.192 -1.603  19.146  1.00 32.86 ? 79  GLN B CG  1 
ATOM   2795 C  CD  . GLN B 1 79  ? -27.637 -2.084  19.179  1.00 35.95 ? 79  GLN B CD  1 
ATOM   2796 O  OE1 . GLN B 1 79  ? -28.535 -1.422  18.650  1.00 38.78 ? 79  GLN B OE1 1 
ATOM   2797 N  NE2 . GLN B 1 79  ? -27.871 -3.233  19.822  1.00 38.49 ? 79  GLN B NE2 1 
ATOM   2798 N  N   . GLY B 1 80  ? -22.823 -1.181  19.628  1.00 21.05 ? 80  GLY B N   1 
ATOM   2799 C  CA  . GLY B 1 80  ? -21.952 -2.037  20.468  1.00 22.48 ? 80  GLY B CA  1 
ATOM   2800 C  C   . GLY B 1 80  ? -20.864 -1.216  21.058  1.00 22.98 ? 80  GLY B C   1 
ATOM   2801 O  O   . GLY B 1 80  ? -20.367 -1.564  22.173  1.00 21.97 ? 80  GLY B O   1 
ATOM   2802 N  N   . LEU B 1 81  ? -20.514 -0.103  20.402  1.00 19.78 ? 81  LEU B N   1 
ATOM   2803 C  CA  . LEU B 1 81  ? -19.509 0.808   21.001  1.00 18.92 ? 81  LEU B CA  1 
ATOM   2804 C  C   . LEU B 1 81  ? -20.108 1.695   22.076  1.00 20.55 ? 81  LEU B C   1 
ATOM   2805 O  O   . LEU B 1 81  ? -21.275 1.530   22.384  1.00 20.48 ? 81  LEU B O   1 
ATOM   2806 C  CB  . LEU B 1 81  ? -18.753 1.607   19.908  1.00 18.42 ? 81  LEU B CB  1 
ATOM   2807 C  CG  . LEU B 1 81  ? -18.143 0.686   18.815  1.00 18.43 ? 81  LEU B CG  1 
ATOM   2808 C  CD1 . LEU B 1 81  ? -17.718 1.549   17.665  1.00 18.98 ? 81  LEU B CD1 1 
ATOM   2809 C  CD2 . LEU B 1 81  ? -16.906 -0.025  19.418  1.00 17.68 ? 81  LEU B CD2 1 
ATOM   2810 N  N   . GLN B 1 82  ? -19.353 2.657   22.569  1.00 22.52 ? 82  GLN B N   1 
ATOM   2811 C  CA  . GLN B 1 82  ? -19.891 3.417   23.679  1.00 29.36 ? 82  GLN B CA  1 
ATOM   2812 C  C   . GLN B 1 82  ? -20.681 4.613   23.237  1.00 31.21 ? 82  GLN B C   1 
ATOM   2813 O  O   . GLN B 1 82  ? -21.250 5.328   24.063  1.00 29.18 ? 82  GLN B O   1 
ATOM   2814 C  CB  . GLN B 1 82  ? -18.830 3.756   24.703  1.00 34.52 ? 82  GLN B CB  1 
ATOM   2815 C  CG  . GLN B 1 82  ? -18.863 2.700   25.805  1.00 43.62 ? 82  GLN B CG  1 
ATOM   2816 C  CD  . GLN B 1 82  ? -17.495 2.470   26.382  1.00 52.01 ? 82  GLN B CD  1 
ATOM   2817 O  OE1 . GLN B 1 82  ? -17.245 1.478   27.091  1.00 55.53 ? 82  GLN B OE1 1 
ATOM   2818 N  NE2 . GLN B 1 82  ? -16.578 3.382   26.059  1.00 48.63 ? 82  GLN B NE2 1 
ATOM   2819 N  N   . SER B 1 83  ? -20.720 4.825   21.930  1.00 22.58 ? 83  SER B N   1 
ATOM   2820 C  CA  . SER B 1 83  ? -21.784 5.648   21.340  1.00 21.17 ? 83  SER B CA  1 
ATOM   2821 C  C   . SER B 1 83  ? -22.221 4.978   20.090  1.00 21.17 ? 83  SER B C   1 
ATOM   2822 O  O   . SER B 1 83  ? -21.584 4.019   19.685  1.00 17.95 ? 83  SER B O   1 
ATOM   2823 C  CB  . SER B 1 83  ? -21.259 7.016   20.993  1.00 24.98 ? 83  SER B CB  1 
ATOM   2824 O  OG  . SER B 1 83  ? -20.845 7.654   22.188  1.00 26.55 ? 83  SER B OG  1 
ATOM   2825 N  N   . ARG B 1 84  ? -23.323 5.431   19.520  1.00 17.73 ? 84  ARG B N   1 
ATOM   2826 C  CA  . ARG B 1 84  ? -23.688 5.053   18.178  1.00 19.97 ? 84  ARG B CA  1 
ATOM   2827 C  C   . ARG B 1 84  ? -22.657 5.694   17.193  1.00 17.54 ? 84  ARG B C   1 
ATOM   2828 O  O   . ARG B 1 84  ? -22.301 6.902   17.246  1.00 16.50 ? 84  ARG B O   1 
ATOM   2829 C  CB  . ARG B 1 84  ? -25.110 5.497   17.854  1.00 21.13 ? 84  ARG B CB  1 
ATOM   2830 C  CG  . ARG B 1 84  ? -25.406 5.380   16.363  1.00 27.58 ? 84  ARG B CG  1 
ATOM   2831 C  CD  . ARG B 1 84  ? -26.819 4.864   16.152  1.00 33.99 ? 84  ARG B CD  1 
ATOM   2832 N  NE  . ARG B 1 84  ? -27.650 6.014   15.976  1.00 43.11 ? 84  ARG B NE  1 
ATOM   2833 C  CZ  . ARG B 1 84  ? -28.972 5.980   15.891  1.00 40.54 ? 84  ARG B CZ  1 
ATOM   2834 N  NH1 . ARG B 1 84  ? -29.627 4.828   15.949  1.00 38.46 ? 84  ARG B NH1 1 
ATOM   2835 N  NH2 . ARG B 1 84  ? -29.626 7.127   15.765  1.00 44.86 ? 84  ARG B NH2 1 
ATOM   2836 N  N   . TYR B 1 85  ? -22.138 4.839   16.265  1.00 13.52 ? 85  TYR B N   1 
ATOM   2837 C  CA  . TYR B 1 85  ? -21.292 5.382   15.221  1.00 11.73 ? 85  TYR B CA  1 
ATOM   2838 C  C   . TYR B 1 85  ? -21.963 5.158   13.947  1.00 12.11 ? 85  TYR B C   1 
ATOM   2839 O  O   . TYR B 1 85  ? -22.381 4.066   13.672  1.00 14.57 ? 85  TYR B O   1 
ATOM   2840 C  CB  . TYR B 1 85  ? -19.947 4.657   15.183  1.00 12.17 ? 85  TYR B CB  1 
ATOM   2841 C  CG  . TYR B 1 85  ? -19.010 5.131   16.239  1.00 11.28 ? 85  TYR B CG  1 
ATOM   2842 C  CD1 . TYR B 1 85  ? -18.028 6.060   15.988  1.00 10.66 ? 85  TYR B CD1 1 
ATOM   2843 C  CD2 . TYR B 1 85  ? -19.150 4.666   17.547  1.00 13.12 ? 85  TYR B CD2 1 
ATOM   2844 C  CE1 . TYR B 1 85  ? -17.144 6.473   16.932  1.00 11.82 ? 85  TYR B CE1 1 
ATOM   2845 C  CE2 . TYR B 1 85  ? -18.310 5.178   18.572  1.00 12.75 ? 85  TYR B CE2 1 
ATOM   2846 C  CZ  . TYR B 1 85  ? -17.335 6.090   18.271  1.00 12.31 ? 85  TYR B CZ  1 
ATOM   2847 O  OH  . TYR B 1 85  ? -16.445 6.501   19.255  1.00 18.83 ? 85  TYR B OH  1 
ATOM   2848 N  N   . SER B 1 86  ? -22.108 6.234   13.162  1.00 11.39 ? 86  SER B N   1 
ATOM   2849 C  CA  . SER B 1 86  ? -22.839 6.118   11.900  1.00 11.76 ? 86  SER B CA  1 
ATOM   2850 C  C   . SER B 1 86  ? -21.792 6.132   10.727  1.00 8.06  ? 86  SER B C   1 
ATOM   2851 O  O   . SER B 1 86  ? -20.762 6.785   10.781  1.00 8.80  ? 86  SER B O   1 
ATOM   2852 C  CB  . SER B 1 86  ? -23.749 7.331   11.659  1.00 14.93 ? 86  SER B CB  1 
ATOM   2853 O  OG  . SER B 1 86  ? -24.785 7.324   12.653  1.00 17.95 ? 86  SER B OG  1 
ATOM   2854 N  N   . ALA B 1 87  ? -22.156 5.356   9.766   1.00 9.12  ? 87  ALA B N   1 
ATOM   2855 C  CA  . ALA B 1 87  ? -21.285 5.201   8.528   1.00 8.78  ? 87  ALA B CA  1 
ATOM   2856 C  C   . ALA B 1 87  ? -21.145 6.553   7.833   1.00 10.27 ? 87  ALA B C   1 
ATOM   2857 O  O   . ALA B 1 87  ? -22.115 7.388   7.808   1.00 11.39 ? 87  ALA B O   1 
ATOM   2858 C  CB  . ALA B 1 87  ? -21.787 4.118   7.634   1.00 11.96 ? 87  ALA B CB  1 
ATOM   2859 N  N   . THR B 1 88  ? -19.971 6.795   7.262   1.00 8.11  ? 88  THR B N   1 
ATOM   2860 C  CA  . THR B 1 88  ? -19.766 7.930   6.355   1.00 9.23  ? 88  THR B CA  1 
ATOM   2861 C  C   . THR B 1 88  ? -19.291 7.532   4.992   1.00 7.67  ? 88  THR B C   1 
ATOM   2862 O  O   . THR B 1 88  ? -19.718 8.073   3.982   1.00 8.43  ? 88  THR B O   1 
ATOM   2863 C  CB  . THR B 1 88  ? -18.954 9.024   7.028   1.00 10.02 ? 88  THR B CB  1 
ATOM   2864 O  OG1 . THR B 1 88  ? -18.965 10.161  6.099   1.00 13.76 ? 88  THR B OG1 1 
ATOM   2865 C  CG2 . THR B 1 88  ? -17.552 8.614   7.403   1.00 10.82 ? 88  THR B CG2 1 
ATOM   2866 N  N   . GLN B 1 89  ? -18.346 6.565   4.920   1.00 7.13  ? 89  GLN B N   1 
ATOM   2867 C  CA  . GLN B 1 89  ? -17.808 6.180   3.615   1.00 6.31  ? 89  GLN B CA  1 
ATOM   2868 C  C   . GLN B 1 89  ? -17.023 4.886   3.776   1.00 5.67  ? 89  GLN B C   1 
ATOM   2869 O  O   . GLN B 1 89  ? -16.676 4.546   4.917   1.00 5.61  ? 89  GLN B O   1 
ATOM   2870 C  CB  . GLN B 1 89  ? -16.858 7.278   2.986   1.00 7.13  ? 89  GLN B CB  1 
ATOM   2871 C  CG  . GLN B 1 89  ? -15.744 7.674   3.919   1.00 9.51  ? 89  GLN B CG  1 
ATOM   2872 C  CD  . GLN B 1 89  ? -14.394 7.160   3.429   1.00 8.90  ? 89  GLN B CD  1 
ATOM   2873 O  OE1 . GLN B 1 89  ? -14.281 6.027   3.143   1.00 9.30  ? 89  GLN B OE1 1 
ATOM   2874 N  NE2 . GLN B 1 89  ? -13.398 8.002   3.202   1.00 13.39 ? 89  GLN B NE2 1 
ATOM   2875 N  N   . LEU B 1 90  ? -16.833 4.161   2.707   1.00 4.24  ? 90  LEU B N   1 
ATOM   2876 C  CA  . LEU B 1 90  ? -15.800 3.120   2.717   1.00 4.71  ? 90  LEU B CA  1 
ATOM   2877 C  C   . LEU B 1 90  ? -14.848 3.337   1.568   1.00 4.85  ? 90  LEU B C   1 
ATOM   2878 O  O   . LEU B 1 90  ? -15.144 3.998   0.583   1.00 4.88  ? 90  LEU B O   1 
ATOM   2879 C  CB  . LEU B 1 90  ? -16.467 1.694   2.694   1.00 5.01  ? 90  LEU B CB  1 
ATOM   2880 C  CG  . LEU B 1 90  ? -17.398 1.404   1.578   1.00 5.71  ? 90  LEU B CG  1 
ATOM   2881 C  CD1 . LEU B 1 90  ? -16.658 1.104   0.257   1.00 7.03  ? 90  LEU B CD1 1 
ATOM   2882 C  CD2 . LEU B 1 90  ? -18.312 0.154   1.868   1.00 6.42  ? 90  LEU B CD2 1 
ATOM   2883 N  N   . HIS B 1 91  ? -13.646 2.715   1.666   1.00 4.23  ? 91  HIS B N   1 
ATOM   2884 C  CA  . HIS B 1 91  ? -12.597 2.826   0.640   1.00 4.09  ? 91  HIS B CA  1 
ATOM   2885 C  C   . HIS B 1 91  ? -11.673 1.683   0.825   1.00 4.03  ? 91  HIS B C   1 
ATOM   2886 O  O   . HIS B 1 91  ? -11.751 0.945   1.787   1.00 3.43  ? 91  HIS B O   1 
ATOM   2887 C  CB  . HIS B 1 91  ? -11.897 4.178   0.784   1.00 4.31  ? 91  HIS B CB  1 
ATOM   2888 C  CG  . HIS B 1 91  ? -11.221 4.358   2.096   1.00 3.73  ? 91  HIS B CG  1 
ATOM   2889 N  ND1 . HIS B 1 91  ? -11.810 4.912   3.199   1.00 4.11  ? 91  HIS B ND1 1 
ATOM   2890 C  CD2 . HIS B 1 91  ? -9.952  3.928   2.466   1.00 3.95  ? 91  HIS B CD2 1 
ATOM   2891 C  CE1 . HIS B 1 91  ? -10.950 4.820   4.214   1.00 4.01  ? 91  HIS B CE1 1 
ATOM   2892 N  NE2 . HIS B 1 91  ? -9.823  4.170   3.776   1.00 3.16  ? 91  HIS B NE2 1 
ATOM   2893 N  N   . LEU B 1 92  ? -10.754 1.575   -0.098  1.00 4.60  ? 92  LEU B N   1 
ATOM   2894 C  CA  . LEU B 1 92  ? -9.755  0.462   -0.089  1.00 4.80  ? 92  LEU B CA  1 
ATOM   2895 C  C   . LEU B 1 92  ? -8.348  0.985   -0.184  1.00 4.42  ? 92  LEU B C   1 
ATOM   2896 O  O   . LEU B 1 92  ? -8.074  2.120   -0.598  1.00 5.07  ? 92  LEU B O   1 
ATOM   2897 C  CB  . LEU B 1 92  ? -10.054 -0.510  -1.199  1.00 6.63  ? 92  LEU B CB  1 
ATOM   2898 C  CG  . LEU B 1 92  ? -11.411 -1.248  -1.017  1.00 7.67  ? 92  LEU B CG  1 
ATOM   2899 C  CD1 . LEU B 1 92  ? -12.378 -0.609  -1.910  1.00 10.34 ? 92  LEU B CD1 1 
ATOM   2900 C  CD2 . LEU B 1 92  ? -11.300 -2.705  -1.308  1.00 9.46  ? 92  LEU B CD2 1 
ATOM   2901 N  N   . HIS B 1 93  ? -7.462  0.047   0.145   1.00 4.37  ? 93  HIS B N   1 
ATOM   2902 C  CA  . HIS B 1 93  ? -5.981  0.210   -0.079  1.00 4.16  ? 93  HIS B CA  1 
ATOM   2903 C  C   . HIS B 1 93  ? -5.473  -0.994  -0.749  1.00 4.39  ? 93  HIS B C   1 
ATOM   2904 O  O   . HIS B 1 93  ? -5.923  -2.126  -0.415  1.00 4.20  ? 93  HIS B O   1 
ATOM   2905 C  CB  . HIS B 1 93  ? -5.290  0.367   1.293   1.00 4.01  ? 93  HIS B CB  1 
ATOM   2906 C  CG  . HIS B 1 93  ? -5.806  1.495   2.102   1.00 4.26  ? 93  HIS B CG  1 
ATOM   2907 N  ND1 . HIS B 1 93  ? -5.224  2.768   2.054   1.00 4.47  ? 93  HIS B ND1 1 
ATOM   2908 C  CD2 . HIS B 1 93  ? -6.873  1.591   2.912   1.00 3.94  ? 93  HIS B CD2 1 
ATOM   2909 C  CE1 . HIS B 1 93  ? -5.904  3.617   2.817   1.00 5.07  ? 93  HIS B CE1 1 
ATOM   2910 N  NE2 . HIS B 1 93  ? -6.882  2.937   3.406   1.00 3.84  ? 93  HIS B NE2 1 
ATOM   2911 N  N   . TRP B 1 94  ? -4.498  -0.845  -1.643  1.00 4.56  ? 94  TRP B N   1 
ATOM   2912 C  CA  . TRP B 1 94  ? -4.008  -1.988  -2.462  1.00 4.05  ? 94  TRP B CA  1 
ATOM   2913 C  C   . TRP B 1 94  ? -2.608  -1.726  -2.908  1.00 4.37  ? 94  TRP B C   1 
ATOM   2914 O  O   . TRP B 1 94  ? -2.026  -0.665  -2.650  1.00 3.94  ? 94  TRP B O   1 
ATOM   2915 C  CB  . TRP B 1 94  ? -4.970  -2.276  -3.623  1.00 4.93  ? 94  TRP B CB  1 
ATOM   2916 C  CG  . TRP B 1 94  ? -5.123  -1.111  -4.558  1.00 4.89  ? 94  TRP B CG  1 
ATOM   2917 C  CD1 . TRP B 1 94  ? -4.259  -0.755  -5.598  1.00 5.22  ? 94  TRP B CD1 1 
ATOM   2918 C  CD2 . TRP B 1 94  ? -6.109  -0.081  -4.458  1.00 4.79  ? 94  TRP B CD2 1 
ATOM   2919 N  NE1 . TRP B 1 94  ? -4.728  0.398   -6.201  1.00 5.44  ? 94  TRP B NE1 1 
ATOM   2920 C  CE2 . TRP B 1 94  ? -5.867  0.836   -5.513  1.00 5.27  ? 94  TRP B CE2 1 
ATOM   2921 C  CE3 . TRP B 1 94  ? -7.191  0.116   -3.626  1.00 5.30  ? 94  TRP B CE3 1 
ATOM   2922 C  CZ2 . TRP B 1 94  ? -6.687  1.945   -5.770  1.00 5.71  ? 94  TRP B CZ2 1 
ATOM   2923 C  CZ3 . TRP B 1 94  ? -8.006  1.241   -3.836  1.00 5.80  ? 94  TRP B CZ3 1 
ATOM   2924 C  CH2 . TRP B 1 94  ? -7.755  2.160   -4.911  1.00 5.88  ? 94  TRP B CH2 1 
ATOM   2925 N  N   . GLY B 1 95  ? -2.054  -2.785  -3.530  1.00 4.62  ? 95  GLY B N   1 
ATOM   2926 C  CA  . GLY B 1 95  ? -0.664  -2.757  -4.033  1.00 5.77  ? 95  GLY B CA  1 
ATOM   2927 C  C   . GLY B 1 95  ? -0.602  -2.437  -5.493  1.00 6.19  ? 95  GLY B C   1 
ATOM   2928 O  O   . GLY B 1 95  ? -1.102  -1.384  -5.985  1.00 5.43  ? 95  GLY B O   1 
ATOM   2929 N  N   . ASN B 1 96  ? 0.010   -3.344  -6.289  1.00 7.09  ? 96  ASN B N   1 
ATOM   2930 C  CA  . ASN B 1 96  ? 0.071   -3.078  -7.751  1.00 8.56  ? 96  ASN B CA  1 
ATOM   2931 C  C   . ASN B 1 96  ? 0.113   -4.410  -8.470  1.00 9.56  ? 96  ASN B C   1 
ATOM   2932 O  O   . ASN B 1 96  ? 0.267   -5.429  -7.840  1.00 9.09  ? 96  ASN B O   1 
ATOM   2933 C  CB  . ASN B 1 96  ? 1.321   -2.211  -8.102  1.00 9.73  ? 96  ASN B CB  1 
ATOM   2934 C  CG  . ASN B 1 96  ? 2.643   -2.941  -7.817  1.00 11.05 ? 96  ASN B CG  1 
ATOM   2935 O  OD1 . ASN B 1 96  ? 3.015   -3.782  -8.683  1.00 16.37 ? 96  ASN B OD1 1 
ATOM   2936 N  ND2 . ASN B 1 96  ? 3.280   -2.767  -6.696  1.00 11.42 ? 96  ASN B ND2 1 
ATOM   2937 N  N   . PRO B 1 97  ? 0.017   -4.399  -9.810  1.00 9.46  ? 97  PRO B N   1 
ATOM   2938 C  CA  . PRO B 1 97  ? -0.123  -5.685  -10.503 1.00 10.52 ? 97  PRO B CA  1 
ATOM   2939 C  C   . PRO B 1 97  ? 1.050   -6.625  -10.355 1.00 10.41 ? 97  PRO B C   1 
ATOM   2940 O  O   . PRO B 1 97  ? 0.827   -7.871  -10.470 1.00 14.07 ? 97  PRO B O   1 
ATOM   2941 C  CB  . PRO B 1 97  ? -0.310  -5.277  -11.998 1.00 13.39 ? 97  PRO B CB  1 
ATOM   2942 C  CG  . PRO B 1 97  ? -0.973  -3.969  -11.865 1.00 12.92 ? 97  PRO B CG  1 
ATOM   2943 C  CD  . PRO B 1 97  ? -0.240  -3.278  -10.714 1.00 11.68 ? 97  PRO B CD  1 
ATOM   2944 N  N   . ASN B 1 98  ? 2.222   -6.064  -10.130 1.00 8.70  ? 98  ASN B N   1 
ATOM   2945 C  CA  . ASN B 1 98  ? 3.412   -6.915  -10.028 1.00 11.66 ? 98  ASN B CA  1 
ATOM   2946 C  C   . ASN B 1 98  ? 3.687   -7.272  -8.581  1.00 15.40 ? 98  ASN B C   1 
ATOM   2947 O  O   . ASN B 1 98  ? 4.586   -8.042  -8.284  1.00 19.21 ? 98  ASN B O   1 
ATOM   2948 C  CB  . ASN B 1 98  ? 4.598   -6.191  -10.703 1.00 12.15 ? 98  ASN B CB  1 
ATOM   2949 C  CG  . ASN B 1 98  ? 4.371   -5.970  -12.180 1.00 10.65 ? 98  ASN B CG  1 
ATOM   2950 O  OD1 . ASN B 1 98  ? 4.168   -6.971  -12.926 1.00 12.14 ? 98  ASN B OD1 1 
ATOM   2951 N  ND2 . ASN B 1 98  ? 4.256   -4.700  -12.598 1.00 12.04 ? 98  ASN B ND2 1 
ATOM   2952 N  N   . ASP B 1 99  ? 2.890   -6.733  -7.671  1.00 12.31 ? 99  ASP B N   1 
ATOM   2953 C  CA  . ASP B 1 99  ? 3.083   -6.983  -6.217  1.00 13.17 ? 99  ASP B CA  1 
ATOM   2954 C  C   . ASP B 1 99  ? 1.756   -6.732  -5.524  1.00 10.70 ? 99  ASP B C   1 
ATOM   2955 O  O   . ASP B 1 99  ? 1.511   -5.674  -4.939  1.00 9.54  ? 99  ASP B O   1 
ATOM   2956 C  CB  . ASP B 1 99  ? 4.140   -6.039  -5.626  1.00 15.78 ? 99  ASP B CB  1 
ATOM   2957 C  CG  . ASP B 1 99  ? 4.509   -6.388  -4.180  1.00 21.47 ? 99  ASP B CG  1 
ATOM   2958 O  OD1 . ASP B 1 99  ? 4.112   -7.441  -3.718  1.00 27.72 ? 99  ASP B OD1 1 
ATOM   2959 O  OD2 . ASP B 1 99  ? 5.159   -5.539  -3.546  1.00 29.37 ? 99  ASP B OD2 1 
ATOM   2960 N  N   . PRO B 1 100 ? 0.839   -7.695  -5.574  1.00 10.03 ? 100 PRO B N   1 
ATOM   2961 C  CA  . PRO B 1 100 ? -0.537  -7.527  -5.033  1.00 10.78 ? 100 PRO B CA  1 
ATOM   2962 C  C   . PRO B 1 100 ? -0.487  -7.753  -3.519  1.00 10.60 ? 100 PRO B C   1 
ATOM   2963 O  O   . PRO B 1 100 ? -1.070  -8.685  -2.985  1.00 11.85 ? 100 PRO B O   1 
ATOM   2964 C  CB  . PRO B 1 100 ? -1.366  -8.553  -5.804  1.00 12.10 ? 100 PRO B CB  1 
ATOM   2965 C  CG  . PRO B 1 100 ? -0.279  -9.646  -6.107  1.00 12.88 ? 100 PRO B CG  1 
ATOM   2966 C  CD  . PRO B 1 100 ? 1.031   -8.967  -6.292  1.00 12.77 ? 100 PRO B CD  1 
ATOM   2967 N  N   . HIS B 1 101 ? 0.186   -6.878  -2.791  1.00 10.32 ? 101 HIS B N   1 
ATOM   2968 C  CA  . HIS B 1 101 ? 0.357   -7.018  -1.312  1.00 11.57 ? 101 HIS B CA  1 
ATOM   2969 C  C   . HIS B 1 101 ? 0.266   -5.708  -0.618  1.00 12.79 ? 101 HIS B C   1 
ATOM   2970 O  O   . HIS B 1 101 ? 1.213   -5.284  0.068   1.00 16.64 ? 101 HIS B O   1 
ATOM   2971 C  CB  . HIS B 1 101 ? 1.625   -7.708  -0.914  1.00 13.44 ? 101 HIS B CB  1 
ATOM   2972 C  CG  . HIS B 1 101 ? 1.706   -9.050  -1.484  1.00 17.12 ? 101 HIS B CG  1 
ATOM   2973 N  ND1 . HIS B 1 101 ? 1.049   -10.137 -0.970  1.00 20.71 ? 101 HIS B ND1 1 
ATOM   2974 C  CD2 . HIS B 1 101 ? 2.342   -9.462  -2.627  1.00 17.24 ? 101 HIS B CD2 1 
ATOM   2975 C  CE1 . HIS B 1 101 ? 1.286   -11.204 -1.803  1.00 21.99 ? 101 HIS B CE1 1 
ATOM   2976 N  NE2 . HIS B 1 101 ? 2.065   -10.779 -2.810  1.00 20.62 ? 101 HIS B NE2 1 
ATOM   2977 N  N   . GLY B 1 102 ? -0.912  -5.140  -0.654  1.00 8.24  ? 102 GLY B N   1 
ATOM   2978 C  CA  . GLY B 1 102 ? -1.097  -3.704  -0.352  1.00 6.99  ? 102 GLY B CA  1 
ATOM   2979 C  C   . GLY B 1 102 ? -2.031  -3.471  0.859   1.00 5.84  ? 102 GLY B C   1 
ATOM   2980 O  O   . GLY B 1 102 ? -2.595  -2.381  0.971   1.00 7.75  ? 102 GLY B O   1 
ATOM   2981 N  N   . SER B 1 103 ? -2.258  -4.417  1.756   1.00 6.24  ? 103 SER B N   1 
ATOM   2982 C  CA  . SER B 1 103 ? -2.965  -4.069  2.973   1.00 6.04  ? 103 SER B CA  1 
ATOM   2983 C  C   . SER B 1 103 ? -2.182  -3.096  3.822   1.00 6.47  ? 103 SER B C   1 
ATOM   2984 O  O   . SER B 1 103 ? -0.938  -2.947  3.648   1.00 7.20  ? 103 SER B O   1 
ATOM   2985 C  CB  . SER B 1 103 ? -3.333  -5.370  3.780   1.00 5.64  ? 103 SER B CB  1 
ATOM   2986 O  OG  . SER B 1 103 ? -2.087  -5.873  4.380   1.00 5.24  ? 103 SER B OG  1 
ATOM   2987 N  N   . GLU B 1 104 ? -2.841  -2.399  4.719   1.00 5.84  ? 104 GLU B N   1 
ATOM   2988 C  CA  . GLU B 1 104 ? -2.204  -1.484  5.630   1.00 5.36  ? 104 GLU B CA  1 
ATOM   2989 C  C   . GLU B 1 104 ? -1.800  -2.218  6.899   1.00 5.16  ? 104 GLU B C   1 
ATOM   2990 O  O   . GLU B 1 104 ? -0.624  -2.231  7.249   1.00 5.82  ? 104 GLU B O   1 
ATOM   2991 C  CB  . GLU B 1 104 ? -3.118  -0.317  5.958   1.00 5.61  ? 104 GLU B CB  1 
ATOM   2992 C  CG  . GLU B 1 104 ? -3.493  0.439   4.648   1.00 6.65  ? 104 GLU B CG  1 
ATOM   2993 C  CD  . GLU B 1 104 ? -3.624  1.931   4.925   1.00 6.14  ? 104 GLU B CD  1 
ATOM   2994 O  OE1 . GLU B 1 104 ? -4.635  2.345   5.533   1.00 7.09  ? 104 GLU B OE1 1 
ATOM   2995 O  OE2 . GLU B 1 104 ? -2.685  2.691   4.585   1.00 7.82  ? 104 GLU B OE2 1 
ATOM   2996 N  N   . HIS B 1 105 ? -2.772  -2.806  7.612   1.00 4.99  ? 105 HIS B N   1 
ATOM   2997 C  CA  . HIS B 1 105 ? -2.321  -3.683  8.719   1.00 5.53  ? 105 HIS B CA  1 
ATOM   2998 C  C   . HIS B 1 105 ? -1.754  -4.926  8.151   1.00 5.79  ? 105 HIS B C   1 
ATOM   2999 O  O   . HIS B 1 105 ? -2.052  -5.414  7.078   1.00 5.92  ? 105 HIS B O   1 
ATOM   3000 C  CB  . HIS B 1 105 ? -3.600  -4.008  9.528   1.00 5.61  ? 105 HIS B CB  1 
ATOM   3001 C  CG  . HIS B 1 105 ? -4.143  -2.798  10.246  1.00 5.70  ? 105 HIS B CG  1 
ATOM   3002 N  ND1 . HIS B 1 105 ? -5.105  -1.959  9.667   1.00 6.25  ? 105 HIS B ND1 1 
ATOM   3003 C  CD2 . HIS B 1 105 ? -3.804  -2.244  11.460  1.00 5.69  ? 105 HIS B CD2 1 
ATOM   3004 C  CE1 . HIS B 1 105 ? -5.324  -0.933  10.510  1.00 6.62  ? 105 HIS B CE1 1 
ATOM   3005 N  NE2 . HIS B 1 105 ? -4.531  -1.109  11.615  1.00 6.79  ? 105 HIS B NE2 1 
ATOM   3006 N  N   . THR B 1 106 ? -0.802  -5.421  8.952   1.00 6.25  ? 106 THR B N   1 
ATOM   3007 C  CA  . THR B 1 106 ? -0.176  -6.722  8.696   1.00 6.68  ? 106 THR B CA  1 
ATOM   3008 C  C   . THR B 1 106 ? -0.443  -7.641  9.890   1.00 5.86  ? 106 THR B C   1 
ATOM   3009 O  O   . THR B 1 106 ? -0.804  -7.183  10.963  1.00 6.08  ? 106 THR B O   1 
ATOM   3010 C  CB  . THR B 1 106 ? 1.322   -6.580  8.387   1.00 7.41  ? 106 THR B CB  1 
ATOM   3011 O  OG1 . THR B 1 106 ? 2.014   -6.059  9.512   1.00 8.94  ? 106 THR B OG1 1 
ATOM   3012 C  CG2 . THR B 1 106 ? 1.522   -5.675  7.130   1.00 8.03  ? 106 THR B CG2 1 
ATOM   3013 N  N   . VAL B 1 107 ? -0.342  -8.940  9.650   1.00 7.00  ? 107 VAL B N   1 
ATOM   3014 C  CA  . VAL B 1 107 ? -0.582  -9.876  10.752  1.00 8.42  ? 107 VAL B CA  1 
ATOM   3015 C  C   . VAL B 1 107 ? 0.619   -10.811 10.787  1.00 8.44  ? 107 VAL B C   1 
ATOM   3016 O  O   . VAL B 1 107 ? 0.967   -11.436 9.803   1.00 10.70 ? 107 VAL B O   1 
ATOM   3017 C  CB  . VAL B 1 107 ? -1.864  -10.740 10.528  1.00 8.22  ? 107 VAL B CB  1 
ATOM   3018 C  CG1 . VAL B 1 107 ? -1.973  -11.786 11.692  1.00 9.61  ? 107 VAL B CG1 1 
ATOM   3019 C  CG2 . VAL B 1 107 ? -3.127  -9.863  10.535  1.00 9.44  ? 107 VAL B CG2 1 
ATOM   3020 N  N   . SER B 1 108 ? 1.274   -10.750 11.951  1.00 10.00 ? 108 SER B N   1 
ATOM   3021 C  CA  . SER B 1 108 ? 2.524   -11.517 12.147  1.00 11.32 ? 108 SER B CA  1 
ATOM   3022 C  C   . SER B 1 108 ? 3.463   -11.252 10.962  1.00 10.63 ? 108 SER B C   1 
ATOM   3023 O  O   . SER B 1 108 ? 4.061   -12.201 10.398  1.00 12.30 ? 108 SER B O   1 
ATOM   3024 C  CB  . SER B 1 108 ? 2.183   -13.012 12.366  1.00 13.69 ? 108 SER B CB  1 
ATOM   3025 O  OG  . SER B 1 108 ? 1.406   -13.143 13.538  1.00 15.24 ? 108 SER B OG  1 
ATOM   3026 N  N   . GLY B 1 109 ? 3.614   -9.984  10.570  1.00 11.02 ? 109 GLY B N   1 
ATOM   3027 C  CA  . GLY B 1 109 ? 4.528   -9.575  9.561   1.00 11.75 ? 109 GLY B CA  1 
ATOM   3028 C  C   . GLY B 1 109 ? 4.079   -9.794  8.107   1.00 13.90 ? 109 GLY B C   1 
ATOM   3029 O  O   . GLY B 1 109 ? 4.891   -9.388  7.179   1.00 18.72 ? 109 GLY B O   1 
ATOM   3030 N  N   . GLN B 1 110 ? 2.892   -10.344 7.879   1.00 13.07 ? 110 GLN B N   1 
ATOM   3031 C  CA  . GLN B 1 110 ? 2.489   -10.582 6.485   1.00 15.51 ? 110 GLN B CA  1 
ATOM   3032 C  C   . GLN B 1 110 ? 1.466   -9.573  6.060   1.00 10.94 ? 110 GLN B C   1 
ATOM   3033 O  O   . GLN B 1 110 ? 0.514   -9.321  6.781   1.00 9.87  ? 110 GLN B O   1 
ATOM   3034 C  CB  . GLN B 1 110 ? 1.875   -11.949 6.403   1.00 19.94 ? 110 GLN B CB  1 
ATOM   3035 C  CG  . GLN B 1 110 ? 2.735   -13.016 7.145   1.00 26.24 ? 110 GLN B CG  1 
ATOM   3036 C  CD  . GLN B 1 110 ? 3.716   -13.757 6.263   1.00 36.83 ? 110 GLN B CD  1 
ATOM   3037 O  OE1 . GLN B 1 110 ? 4.605   -13.169 5.613   1.00 37.19 ? 110 GLN B OE1 1 
ATOM   3038 N  NE2 . GLN B 1 110 ? 3.575   -15.071 6.253   1.00 39.63 ? 110 GLN B NE2 1 
ATOM   3039 N  N   . HIS B 1 111 ? 1.694   -9.050  4.862   1.00 11.10 ? 111 HIS B N   1 
ATOM   3040 C  CA  . HIS B 1 111 ? 0.680   -8.246  4.152   1.00 11.39 ? 111 HIS B CA  1 
ATOM   3041 C  C   . HIS B 1 111 ? -0.338  -9.073  3.543   1.00 10.16 ? 111 HIS B C   1 
ATOM   3042 O  O   . HIS B 1 111 ? -0.060  -10.175 3.049   1.00 14.47 ? 111 HIS B O   1 
ATOM   3043 C  CB  . HIS B 1 111 ? 1.206   -7.385  2.974   1.00 14.86 ? 111 HIS B CB  1 
ATOM   3044 C  CG  . HIS B 1 111 ? 1.845   -6.080  3.386   1.00 13.49 ? 111 HIS B CG  1 
ATOM   3045 N  ND1 . HIS B 1 111 ? 1.180   -4.880  3.534   1.00 16.06 ? 111 HIS B ND1 1 
ATOM   3046 C  CD2 . HIS B 1 111 ? 3.173   -5.861  3.761   1.00 16.18 ? 111 HIS B CD2 1 
ATOM   3047 C  CE1 . HIS B 1 111 ? 2.080   -3.947  3.961   1.00 16.28 ? 111 HIS B CE1 1 
ATOM   3048 N  NE2 . HIS B 1 111 ? 3.303   -4.571  4.125   1.00 18.74 ? 111 HIS B NE2 1 
ATOM   3049 N  N   . PHE B 1 112 ? -1.556  -8.580  3.520   1.00 7.04  ? 112 PHE B N   1 
ATOM   3050 C  CA  . PHE B 1 112 ? -2.566  -9.126  2.735   1.00 7.36  ? 112 PHE B CA  1 
ATOM   3051 C  C   . PHE B 1 112 ? -2.652  -8.376  1.410   1.00 5.67  ? 112 PHE B C   1 
ATOM   3052 O  O   . PHE B 1 112 ? -1.960  -7.413  1.213   1.00 6.74  ? 112 PHE B O   1 
ATOM   3053 C  CB  . PHE B 1 112 ? -3.921  -9.092  3.507   1.00 9.20  ? 112 PHE B CB  1 
ATOM   3054 C  CG  . PHE B 1 112 ? -3.970  -10.102 4.627   1.00 9.33  ? 112 PHE B CG  1 
ATOM   3055 C  CD1 . PHE B 1 112 ? -4.662  -11.278 4.475   1.00 13.13 ? 112 PHE B CD1 1 
ATOM   3056 C  CD2 . PHE B 1 112 ? -3.297  -9.785  5.802   1.00 12.54 ? 112 PHE B CD2 1 
ATOM   3057 C  CE1 . PHE B 1 112 ? -4.624  -12.242 5.537   1.00 15.12 ? 112 PHE B CE1 1 
ATOM   3058 C  CE2 . PHE B 1 112 ? -3.278  -10.716 6.833   1.00 16.01 ? 112 PHE B CE2 1 
ATOM   3059 C  CZ  . PHE B 1 112 ? -3.954  -11.896 6.679   1.00 16.50 ? 112 PHE B CZ  1 
ATOM   3060 N  N   . ALA B 1 113 ? -3.437  -8.894  0.469   1.00 5.20  ? 113 ALA B N   1 
ATOM   3061 C  CA  . ALA B 1 113 ? -3.475  -8.350  -0.840  1.00 5.61  ? 113 ALA B CA  1 
ATOM   3062 C  C   . ALA B 1 113 ? -3.991  -6.909  -0.795  1.00 5.14  ? 113 ALA B C   1 
ATOM   3063 O  O   . ALA B 1 113 ? -3.556  -6.039  -1.583  1.00 6.47  ? 113 ALA B O   1 
ATOM   3064 C  CB  . ALA B 1 113 ? -4.377  -9.182  -1.809  1.00 6.30  ? 113 ALA B CB  1 
ATOM   3065 N  N   . ALA B 1 114 ? -5.030  -6.641  0.008   1.00 4.61  ? 114 ALA B N   1 
ATOM   3066 C  CA  . ALA B 1 114 ? -5.705  -5.307  0.021   1.00 4.19  ? 114 ALA B CA  1 
ATOM   3067 C  C   . ALA B 1 114 ? -6.432  -5.246  1.334   1.00 4.33  ? 114 ALA B C   1 
ATOM   3068 O  O   . ALA B 1 114 ? -6.400  -6.136  2.208   1.00 4.13  ? 114 ALA B O   1 
ATOM   3069 C  CB  . ALA B 1 114 ? -6.679  -5.172  -1.176  1.00 4.62  ? 114 ALA B CB  1 
ATOM   3070 N  N   . GLU B 1 115 ? -7.024  -4.059  1.573   1.00 4.12  ? 115 GLU B N   1 
ATOM   3071 C  CA  . GLU B 1 115 ? -7.762  -3.820  2.804   1.00 4.22  ? 115 GLU B CA  1 
ATOM   3072 C  C   . GLU B 1 115 ? -8.929  -2.903  2.544   1.00 4.71  ? 115 GLU B C   1 
ATOM   3073 O  O   . GLU B 1 115 ? -8.738  -1.884  1.877   1.00 5.67  ? 115 GLU B O   1 
ATOM   3074 C  CB  . GLU B 1 115 ? -6.798  -3.257  3.867   1.00 4.79  ? 115 GLU B CB  1 
ATOM   3075 C  CG  . GLU B 1 115 ? -7.374  -3.155  5.275   1.00 5.78  ? 115 GLU B CG  1 
ATOM   3076 C  CD  . GLU B 1 115 ? -6.287  -2.890  6.319   1.00 6.41  ? 115 GLU B CD  1 
ATOM   3077 O  OE1 . GLU B 1 115 ? -6.588  -2.250  7.356   1.00 6.54  ? 115 GLU B OE1 1 
ATOM   3078 O  OE2 . GLU B 1 115 ? -5.118  -3.347  6.116   1.00 6.92  ? 115 GLU B OE2 1 
ATOM   3079 N  N   . LEU B 1 116 ? -10.092 -3.198  3.108   1.00 4.10  ? 116 LEU B N   1 
ATOM   3080 C  CA  . LEU B 1 116 ? -11.303 -2.376  3.041   1.00 4.01  ? 116 LEU B CA  1 
ATOM   3081 C  C   . LEU B 1 116 ? -11.442 -1.693  4.367   1.00 4.16  ? 116 LEU B C   1 
ATOM   3082 O  O   . LEU B 1 116 ? -11.328 -2.324  5.472   1.00 4.78  ? 116 LEU B O   1 
ATOM   3083 C  CB  . LEU B 1 116 ? -12.553 -3.312  2.825   1.00 4.66  ? 116 LEU B CB  1 
ATOM   3084 C  CG  . LEU B 1 116 ? -13.855 -2.495  3.007   1.00 5.24  ? 116 LEU B CG  1 
ATOM   3085 C  CD1 . LEU B 1 116 ? -14.139 -1.656  1.803   1.00 6.77  ? 116 LEU B CD1 1 
ATOM   3086 C  CD2 . LEU B 1 116 ? -14.937 -3.481  3.160   1.00 6.58  ? 116 LEU B CD2 1 
ATOM   3087 N  N   . HIS B 1 117 ? -11.696 -0.386  4.337   1.00 3.91  ? 117 HIS B N   1 
ATOM   3088 C  CA  . HIS B 1 117 ? -11.995 0.396   5.544   1.00 4.09  ? 117 HIS B CA  1 
ATOM   3089 C  C   . HIS B 1 117 ? -13.383 0.973   5.473   1.00 3.87  ? 117 HIS B C   1 
ATOM   3090 O  O   . HIS B 1 117 ? -13.741 1.636   4.468   1.00 4.29  ? 117 HIS B O   1 
ATOM   3091 C  CB  . HIS B 1 117 ? -11.035 1.557   5.691   1.00 4.19  ? 117 HIS B CB  1 
ATOM   3092 C  CG  . HIS B 1 117 ? -9.678  1.102   6.022   1.00 4.48  ? 117 HIS B CG  1 
ATOM   3093 N  ND1 . HIS B 1 117 ? -8.551  1.859   5.789   1.00 4.36  ? 117 HIS B ND1 1 
ATOM   3094 C  CD2 . HIS B 1 117 ? -9.269  -0.103  6.585   1.00 5.22  ? 117 HIS B CD2 1 
ATOM   3095 C  CE1 . HIS B 1 117 ? -7.454  1.185   6.233   1.00 4.84  ? 117 HIS B CE1 1 
ATOM   3096 N  NE2 . HIS B 1 117 ? -7.882  -0.031  6.694   1.00 4.50  ? 117 HIS B NE2 1 
ATOM   3097 N  N   . ILE B 1 118 ? -14.230 0.680   6.466   1.00 4.41  ? 118 ILE B N   1 
ATOM   3098 C  CA  . ILE B 1 118 ? -15.544 1.337   6.512   1.00 5.16  ? 118 ILE B CA  1 
ATOM   3099 C  C   . ILE B 1 118 ? -15.556 2.318   7.637   1.00 5.02  ? 118 ILE B C   1 
ATOM   3100 O  O   . ILE B 1 118 ? -15.363 1.965   8.831   1.00 5.55  ? 118 ILE B O   1 
ATOM   3101 C  CB  . ILE B 1 118 ? -16.645 0.277   6.735   1.00 5.35  ? 118 ILE B CB  1 
ATOM   3102 C  CG1 . ILE B 1 118 ? -16.542 -0.928  5.773   1.00 5.89  ? 118 ILE B CG1 1 
ATOM   3103 C  CG2 . ILE B 1 118 ? -18.032 1.009   6.701   1.00 6.68  ? 118 ILE B CG2 1 
ATOM   3104 C  CD1 . ILE B 1 118 ? -17.636 -2.023  5.970   1.00 8.40  ? 118 ILE B CD1 1 
ATOM   3105 N  N   . VAL B 1 119 ? -15.571 3.635   7.314   1.00 5.65  ? 119 VAL B N   1 
ATOM   3106 C  CA  . VAL B 1 119 ? -15.336 4.717   8.242   1.00 7.11  ? 119 VAL B CA  1 
ATOM   3107 C  C   . VAL B 1 119 ? -16.682 5.115   8.871   1.00 6.71  ? 119 VAL B C   1 
ATOM   3108 O  O   . VAL B 1 119 ? -17.632 5.386   8.099   1.00 7.00  ? 119 VAL B O   1 
ATOM   3109 C  CB  . VAL B 1 119 ? -14.770 5.958   7.491   1.00 7.22  ? 119 VAL B CB  1 
ATOM   3110 C  CG1 . VAL B 1 119 ? -14.423 7.044   8.506   1.00 9.10  ? 119 VAL B CG1 1 
ATOM   3111 C  CG2 . VAL B 1 119 ? -13.408 5.561   6.749   1.00 7.40  ? 119 VAL B CG2 1 
ATOM   3112 N  N   . HIS B 1 120 ? -16.680 5.221   10.177  1.00 6.80  ? 120 HIS B N   1 
ATOM   3113 C  CA  . HIS B 1 120 ? -17.895 5.691   10.895  1.00 7.95  ? 120 HIS B CA  1 
ATOM   3114 C  C   . HIS B 1 120 ? -17.468 6.821   11.781  1.00 8.77  ? 120 HIS B C   1 
ATOM   3115 O  O   . HIS B 1 120 ? -16.327 7.000   12.169  1.00 8.38  ? 120 HIS B O   1 
ATOM   3116 C  CB  . HIS B 1 120 ? -18.492 4.578   11.813  1.00 7.92  ? 120 HIS B CB  1 
ATOM   3117 C  CG  . HIS B 1 120 ? -18.892 3.347   11.088  1.00 7.16  ? 120 HIS B CG  1 
ATOM   3118 N  ND1 . HIS B 1 120 ? -17.908 2.473   10.472  1.00 7.83  ? 120 HIS B ND1 1 
ATOM   3119 C  CD2 . HIS B 1 120 ? -20.114 2.746   10.867  1.00 8.25  ? 120 HIS B CD2 1 
ATOM   3120 C  CE1 . HIS B 1 120 ? -18.542 1.449   9.960   1.00 8.67  ? 120 HIS B CE1 1 
ATOM   3121 N  NE2 . HIS B 1 120 ? -19.884 1.559   10.197  1.00 8.42  ? 120 HIS B NE2 1 
ATOM   3122 N  N   . TYR B 1 121 ? -18.466 7.650   12.173  1.00 10.60 ? 121 TYR B N   1 
ATOM   3123 C  CA  . TYR B 1 121 ? -18.191 8.733   13.069  1.00 12.12 ? 121 TYR B CA  1 
ATOM   3124 C  C   . TYR B 1 121 ? -19.230 8.742   14.197  1.00 12.49 ? 121 TYR B C   1 
ATOM   3125 O  O   . TYR B 1 121 ? -20.300 8.210   14.060  1.00 11.71 ? 121 TYR B O   1 
ATOM   3126 C  CB  . TYR B 1 121 ? -18.228 10.113  12.362  1.00 13.03 ? 121 TYR B CB  1 
ATOM   3127 C  CG  . TYR B 1 121 ? -19.603 10.557  11.902  1.00 12.20 ? 121 TYR B CG  1 
ATOM   3128 C  CD1 . TYR B 1 121 ? -20.294 11.523  12.641  1.00 14.65 ? 121 TYR B CD1 1 
ATOM   3129 C  CD2 . TYR B 1 121 ? -20.221 10.001  10.747  1.00 15.28 ? 121 TYR B CD2 1 
ATOM   3130 C  CE1 . TYR B 1 121 ? -21.537 11.946  12.210  1.00 16.14 ? 121 TYR B CE1 1 
ATOM   3131 C  CE2 . TYR B 1 121 ? -21.494 10.433  10.361  1.00 16.35 ? 121 TYR B CE2 1 
ATOM   3132 C  CZ  . TYR B 1 121 ? -22.097 11.414  11.136  1.00 18.20 ? 121 TYR B CZ  1 
ATOM   3133 O  OH  . TYR B 1 121 ? -23.346 11.841  10.710  1.00 25.42 ? 121 TYR B OH  1 
ATOM   3134 N  N   . ASN B 1 122 ? -18.829 9.330   15.321  1.00 12.95 ? 122 ASN B N   1 
ATOM   3135 C  CA  . ASN B 1 122 ? -19.723 9.315   16.472  1.00 15.08 ? 122 ASN B CA  1 
ATOM   3136 C  C   . ASN B 1 122 ? -20.861 10.369  16.220  1.00 14.60 ? 122 ASN B C   1 
ATOM   3137 O  O   . ASN B 1 122 ? -20.645 11.558  16.439  1.00 15.50 ? 122 ASN B O   1 
ATOM   3138 C  CB  . ASN B 1 122 ? -18.927 9.664   17.708  1.00 14.25 ? 122 ASN B CB  1 
ATOM   3139 C  CG  . ASN B 1 122 ? -19.759 9.573   18.958  1.00 18.59 ? 122 ASN B CG  1 
ATOM   3140 O  OD1 . ASN B 1 122 ? -20.961 9.688   18.907  1.00 16.59 ? 122 ASN B OD1 1 
ATOM   3141 N  ND2 . ASN B 1 122 ? -19.112 9.274   20.097  1.00 20.86 ? 122 ASN B ND2 1 
ATOM   3142 N  N   . SER B 1 123 ? -21.979 9.843   15.782  1.00 16.34 ? 123 SER B N   1 
ATOM   3143 C  CA  . SER B 1 123 ? -23.099 10.724  15.415  1.00 16.98 ? 123 SER B CA  1 
ATOM   3144 C  C   . SER B 1 123 ? -23.943 11.118  16.647  1.00 23.12 ? 123 SER B C   1 
ATOM   3145 O  O   . SER B 1 123 ? -24.811 12.028  16.520  1.00 21.61 ? 123 SER B O   1 
ATOM   3146 C  CB  . SER B 1 123 ? -23.945 10.035  14.389  1.00 17.07 ? 123 SER B CB  1 
ATOM   3147 O  OG  . SER B 1 123 ? -24.277 8.756   14.772  1.00 19.44 ? 123 SER B OG  1 
ATOM   3148 N  N   . ASP B 1 124 ? -23.749 10.427  17.763  1.00 19.27 ? 124 ASP B N   1 
ATOM   3149 C  CA  . ASP B 1 124 ? -24.336 10.896  19.045  1.00 21.12 ? 124 ASP B CA  1 
ATOM   3150 C  C   . ASP B 1 124 ? -23.747 12.236  19.447  1.00 21.02 ? 124 ASP B C   1 
ATOM   3151 O  O   . ASP B 1 124 ? -24.489 13.140  19.925  1.00 21.06 ? 124 ASP B O   1 
ATOM   3152 C  CB  . ASP B 1 124 ? -24.139 9.862   20.155  1.00 18.30 ? 124 ASP B CB  1 
ATOM   3153 C  CG  . ASP B 1 124 ? -25.058 8.663   20.029  1.00 20.89 ? 124 ASP B CG  1 
ATOM   3154 O  OD1 . ASP B 1 124 ? -26.109 8.742   19.299  1.00 24.82 ? 124 ASP B OD1 1 
ATOM   3155 O  OD2 . ASP B 1 124 ? -24.804 7.618   20.709  1.00 22.45 ? 124 ASP B OD2 1 
ATOM   3156 N  N   . LEU B 1 125 ? -22.458 12.441  19.221  1.00 17.65 ? 125 LEU B N   1 
ATOM   3157 C  CA  . LEU B 1 125 ? -21.706 13.639  19.665  1.00 16.64 ? 125 LEU B CA  1 
ATOM   3158 C  C   . LEU B 1 125 ? -21.510 14.683  18.596  1.00 21.27 ? 125 LEU B C   1 
ATOM   3159 O  O   . LEU B 1 125 ? -21.458 15.885  18.888  1.00 20.89 ? 125 LEU B O   1 
ATOM   3160 C  CB  . LEU B 1 125 ? -20.337 13.321  20.282  1.00 19.26 ? 125 LEU B CB  1 
ATOM   3161 C  CG  . LEU B 1 125 ? -20.319 12.347  21.475  1.00 19.96 ? 125 LEU B CG  1 
ATOM   3162 C  CD1 . LEU B 1 125 ? -18.992 12.074  22.174  1.00 20.08 ? 125 LEU B CD1 1 
ATOM   3163 C  CD2 . LEU B 1 125 ? -21.232 12.928  22.559  1.00 22.10 ? 125 LEU B CD2 1 
ATOM   3164 N  N   . TYR B 1 126 ? -21.420 14.264  17.315  1.00 18.21 ? 126 TYR B N   1 
ATOM   3165 C  CA  . TYR B 1 126 ? -21.000 15.199  16.274  1.00 18.90 ? 126 TYR B CA  1 
ATOM   3166 C  C   . TYR B 1 126 ? -21.949 15.178  15.112  1.00 18.50 ? 126 TYR B C   1 
ATOM   3167 O  O   . TYR B 1 126 ? -22.581 14.153  14.794  1.00 19.68 ? 126 TYR B O   1 
ATOM   3168 C  CB  . TYR B 1 126 ? -19.524 14.892  15.844  1.00 17.87 ? 126 TYR B CB  1 
ATOM   3169 C  CG  . TYR B 1 126 ? -18.638 14.781  16.982  1.00 17.25 ? 126 TYR B CG  1 
ATOM   3170 C  CD1 . TYR B 1 126 ? -18.371 15.897  17.766  1.00 21.31 ? 126 TYR B CD1 1 
ATOM   3171 C  CD2 . TYR B 1 126 ? -18.045 13.553  17.332  1.00 17.65 ? 126 TYR B CD2 1 
ATOM   3172 C  CE1 . TYR B 1 126 ? -17.570 15.802  18.879  1.00 21.84 ? 126 TYR B CE1 1 
ATOM   3173 C  CE2 . TYR B 1 126 ? -17.229 13.460  18.415  1.00 19.58 ? 126 TYR B CE2 1 
ATOM   3174 C  CZ  . TYR B 1 126 ? -16.984 14.591  19.191  1.00 21.79 ? 126 TYR B CZ  1 
ATOM   3175 O  OH  . TYR B 1 126 ? -16.162 14.527  20.286  1.00 24.49 ? 126 TYR B OH  1 
ATOM   3176 N  N   . PRO B 1 127 ? -22.062 16.349  14.457  1.00 24.17 ? 127 PRO B N   1 
ATOM   3177 C  CA  . PRO B 1 127 ? -23.038 16.489  13.402  1.00 25.62 ? 127 PRO B CA  1 
ATOM   3178 C  C   . PRO B 1 127 ? -22.537 15.992  12.061  1.00 24.13 ? 127 PRO B C   1 
ATOM   3179 O  O   . PRO B 1 127 ? -23.362 15.816  11.162  1.00 27.09 ? 127 PRO B O   1 
ATOM   3180 C  CB  . PRO B 1 127 ? -23.284 18.023  13.345  1.00 27.44 ? 127 PRO B CB  1 
ATOM   3181 C  CG  . PRO B 1 127 ? -22.443 18.639  14.409  1.00 28.69 ? 127 PRO B CG  1 
ATOM   3182 C  CD  . PRO B 1 127 ? -21.390 17.619  14.774  1.00 23.98 ? 127 PRO B CD  1 
ATOM   3183 N  N   . ASP B 1 128 ? -21.234 15.684  11.949  1.00 22.42 ? 128 ASP B N   1 
ATOM   3184 C  CA  . ASP B 1 128 ? -20.705 15.186  10.694  1.00 21.75 ? 128 ASP B CA  1 
ATOM   3185 C  C   . ASP B 1 128 ? -19.343 14.568  10.955  1.00 21.82 ? 128 ASP B C   1 
ATOM   3186 O  O   . ASP B 1 128 ? -18.720 14.800  12.002  1.00 20.36 ? 128 ASP B O   1 
ATOM   3187 C  CB  . ASP B 1 128 ? -20.594 16.380  9.727   1.00 21.91 ? 128 ASP B CB  1 
ATOM   3188 C  CG  . ASP B 1 128 ? -19.726 17.429  10.248  1.00 27.38 ? 128 ASP B CG  1 
ATOM   3189 O  OD1 . ASP B 1 128 ? -20.216 18.303  11.031  1.00 34.57 ? 128 ASP B OD1 1 
ATOM   3190 O  OD2 . ASP B 1 128 ? -18.568 17.457  9.831   1.00 28.53 ? 128 ASP B OD2 1 
ATOM   3191 N  N   . ALA B 1 129 ? -18.941 13.662  10.069  1.00 20.07 ? 129 ALA B N   1 
ATOM   3192 C  CA  . ALA B 1 129 ? -17.639 13.098  10.141  1.00 19.97 ? 129 ALA B CA  1 
ATOM   3193 C  C   . ALA B 1 129 ? -16.423 14.045  10.119  1.00 17.71 ? 129 ALA B C   1 
ATOM   3194 O  O   . ALA B 1 129 ? -15.426 13.789  10.774  1.00 18.19 ? 129 ALA B O   1 
ATOM   3195 C  CB  . ALA B 1 129 ? -17.484 12.013  9.046   1.00 21.29 ? 129 ALA B CB  1 
ATOM   3196 N  N   A SER B 1 130 ? -16.542 15.140  9.367   0.50 19.84 ? 130 SER B N   1 
ATOM   3197 N  N   B SER B 1 130 ? -16.475 15.149  9.369   0.50 18.72 ? 130 SER B N   1 
ATOM   3198 C  CA  A SER B 1 130 ? -15.483 16.145  9.268   0.50 22.49 ? 130 SER B CA  1 
ATOM   3199 C  CA  B SER B 1 130 ? -15.314 16.067  9.343   0.50 20.48 ? 130 SER B CA  1 
ATOM   3200 C  C   A SER B 1 130 ? -15.127 16.660  10.682  0.50 22.02 ? 130 SER B C   1 
ATOM   3201 C  C   B SER B 1 130 ? -15.092 16.608  10.780  0.50 20.56 ? 130 SER B C   1 
ATOM   3202 O  O   A SER B 1 130 ? -13.946 16.647  11.093  0.50 23.87 ? 130 SER B O   1 
ATOM   3203 O  O   B SER B 1 130 ? -13.971 16.561  11.323  0.50 21.54 ? 130 SER B O   1 
ATOM   3204 C  CB  A SER B 1 130 ? -15.953 17.285  8.360   0.50 25.27 ? 130 SER B CB  1 
ATOM   3205 C  CB  B SER B 1 130 ? -15.517 17.190  8.321   0.50 21.85 ? 130 SER B CB  1 
ATOM   3206 O  OG  A SER B 1 130 ? -15.993 16.853  7.007   0.50 26.34 ? 130 SER B OG  1 
ATOM   3207 O  OG  B SER B 1 130 ? -14.342 17.956  8.121   0.50 21.31 ? 130 SER B OG  1 
ATOM   3208 N  N   . THR B 1 131 ? -16.160 17.065  11.409  1.00 21.75 ? 131 THR B N   1 
ATOM   3209 C  CA  . THR B 1 131 ? -16.089 17.511  12.829  1.00 23.80 ? 131 THR B CA  1 
ATOM   3210 C  C   . THR B 1 131 ? -15.537 16.471  13.763  1.00 23.54 ? 131 THR B C   1 
ATOM   3211 O  O   . THR B 1 131 ? -14.662 16.760  14.572  1.00 22.74 ? 131 THR B O   1 
ATOM   3212 C  CB  . THR B 1 131 ? -17.513 17.905  13.289  1.00 23.37 ? 131 THR B CB  1 
ATOM   3213 O  OG1 . THR B 1 131 ? -17.896 19.048  12.503  1.00 28.21 ? 131 THR B OG1 1 
ATOM   3214 C  CG2 . THR B 1 131 ? -17.589 18.277  14.883  1.00 26.17 ? 131 THR B CG2 1 
ATOM   3215 N  N   . ALA B 1 132 ? -16.010 15.219  13.596  1.00 19.18 ? 132 ALA B N   1 
ATOM   3216 C  CA  . ALA B 1 132 ? -15.631 14.117  14.447  1.00 18.28 ? 132 ALA B CA  1 
ATOM   3217 C  C   . ALA B 1 132 ? -14.160 13.819  14.275  1.00 17.72 ? 132 ALA B C   1 
ATOM   3218 O  O   . ALA B 1 132 ? -13.544 13.316  15.253  1.00 17.27 ? 132 ALA B O   1 
ATOM   3219 C  CB  . ALA B 1 132 ? -16.493 12.894  14.119  1.00 17.79 ? 132 ALA B CB  1 
ATOM   3220 N  N   . SER B 1 133 ? -13.651 14.061  13.053  1.00 18.84 ? 133 SER B N   1 
ATOM   3221 C  CA  . SER B 1 133 ? -12.341 13.539  12.607  1.00 20.23 ? 133 SER B CA  1 
ATOM   3222 C  C   . SER B 1 133 ? -11.188 14.102  13.382  1.00 21.79 ? 133 SER B C   1 
ATOM   3223 O  O   . SER B 1 133 ? -10.079 13.513  13.440  1.00 22.53 ? 133 SER B O   1 
ATOM   3224 C  CB  . SER B 1 133 ? -12.168 13.667  11.078  1.00 19.44 ? 133 SER B CB  1 
ATOM   3225 O  OG  . SER B 1 133 ? -11.897 15.039  10.749  1.00 22.05 ? 133 SER B OG  1 
ATOM   3226 N  N   . ASN B 1 134 ? -11.411 15.236  14.036  1.00 22.08 ? 134 ASN B N   1 
ATOM   3227 C  CA  . ASN B 1 134 ? -10.346 15.699  14.907  1.00 24.93 ? 134 ASN B CA  1 
ATOM   3228 C  C   . ASN B 1 134 ? -10.684 15.655  16.367  1.00 24.89 ? 134 ASN B C   1 
ATOM   3229 O  O   . ASN B 1 134 ? -10.044 16.278  17.151  1.00 27.18 ? 134 ASN B O   1 
ATOM   3230 C  CB  . ASN B 1 134 ? -9.689  17.001  14.445  1.00 35.17 ? 134 ASN B CB  1 
ATOM   3231 C  CG  . ASN B 1 134 ? -10.697 17.995  13.975  1.00 34.48 ? 134 ASN B CG  1 
ATOM   3232 O  OD1 . ASN B 1 134 ? -11.824 18.063  14.493  1.00 42.67 ? 134 ASN B OD1 1 
ATOM   3233 N  ND2 . ASN B 1 134 ? -10.342 18.722  12.955  1.00 43.67 ? 134 ASN B ND2 1 
ATOM   3234 N  N   . LYS B 1 135 ? -11.626 14.813  16.747  1.00 21.79 ? 135 LYS B N   1 
ATOM   3235 C  CA  . LYS B 1 135 ? -11.979 14.656  18.197  1.00 27.88 ? 135 LYS B CA  1 
ATOM   3236 C  C   . LYS B 1 135 ? -11.580 13.274  18.681  1.00 27.58 ? 135 LYS B C   1 
ATOM   3237 O  O   . LYS B 1 135 ? -11.711 12.318  17.955  1.00 22.46 ? 135 LYS B O   1 
ATOM   3238 C  CB  . LYS B 1 135 ? -13.499 14.813  18.389  1.00 26.44 ? 135 LYS B CB  1 
ATOM   3239 C  CG  . LYS B 1 135 ? -14.089 16.083  17.684  1.00 31.26 ? 135 LYS B CG  1 
ATOM   3240 C  CD  . LYS B 1 135 ? -14.030 17.369  18.525  1.00 39.33 ? 135 LYS B CD  1 
ATOM   3241 C  CE  . LYS B 1 135 ? -13.594 18.624  17.739  1.00 44.86 ? 135 LYS B CE  1 
ATOM   3242 N  NZ  . LYS B 1 135 ? -14.333 19.001  16.495  1.00 44.95 ? 135 LYS B NZ  1 
ATOM   3243 N  N   . SER B 1 136 ? -11.127 13.128  19.920  1.00 31.18 ? 136 SER B N   1 
ATOM   3244 C  CA  . SER B 1 136 ? -10.699 11.784  20.379  1.00 27.84 ? 136 SER B CA  1 
ATOM   3245 C  C   . SER B 1 136 ? -11.804 10.670  20.252  1.00 26.97 ? 136 SER B C   1 
ATOM   3246 O  O   . SER B 1 136 ? -12.932 10.822  20.722  1.00 25.96 ? 136 SER B O   1 
ATOM   3247 C  CB  . SER B 1 136 ? -10.195 11.901  21.818  1.00 36.04 ? 136 SER B CB  1 
ATOM   3248 O  OG  . SER B 1 136 ? -9.309  10.832  22.133  1.00 47.32 ? 136 SER B OG  1 
ATOM   3249 N  N   . GLU B 1 137 ? -11.447 9.534   19.623  1.00 26.62 ? 137 GLU B N   1 
ATOM   3250 C  CA  . GLU B 1 137 ? -12.410 8.452   19.294  1.00 26.70 ? 137 GLU B CA  1 
ATOM   3251 C  C   . GLU B 1 137 ? -13.650 8.973   18.574  1.00 22.04 ? 137 GLU B C   1 
ATOM   3252 O  O   . GLU B 1 137 ? -14.743 8.403   18.740  1.00 24.03 ? 137 GLU B O   1 
ATOM   3253 C  CB  . GLU B 1 137 ? -12.931 7.720   20.558  1.00 32.39 ? 137 GLU B CB  1 
ATOM   3254 C  CG  . GLU B 1 137 ? -11.932 7.397   21.669  1.00 40.61 ? 137 GLU B CG  1 
ATOM   3255 C  CD  . GLU B 1 137 ? -12.623 6.929   22.970  1.00 50.56 ? 137 GLU B CD  1 
ATOM   3256 O  OE1 . GLU B 1 137 ? -11.948 6.955   24.023  1.00 55.41 ? 137 GLU B OE1 1 
ATOM   3257 O  OE2 . GLU B 1 137 ? -13.818 6.521   22.959  1.00 47.33 ? 137 GLU B OE2 1 
ATOM   3258 N  N   . GLY B 1 138 ? -13.510 10.076  17.844  1.00 16.08 ? 138 GLY B N   1 
ATOM   3259 C  CA  . GLY B 1 138 ? -14.555 10.652  16.986  1.00 14.15 ? 138 GLY B CA  1 
ATOM   3260 C  C   . GLY B 1 138 ? -14.896 9.729   15.842  1.00 12.24 ? 138 GLY B C   1 
ATOM   3261 O  O   . GLY B 1 138 ? -15.986 9.764   15.246  1.00 11.94 ? 138 GLY B O   1 
ATOM   3262 N  N   . LEU B 1 139 ? -13.884 8.914   15.442  1.00 10.66 ? 139 LEU B N   1 
ATOM   3263 C  CA  . LEU B 1 139 ? -14.093 7.975   14.303  1.00 9.56  ? 139 LEU B CA  1 
ATOM   3264 C  C   . LEU B 1 139 ? -13.972 6.540   14.795  1.00 8.63  ? 139 LEU B C   1 
ATOM   3265 O  O   . LEU B 1 139 ? -13.170 6.222   15.690  1.00 9.70  ? 139 LEU B O   1 
ATOM   3266 C  CB  . LEU B 1 139 ? -13.136 8.179   13.137  1.00 10.03 ? 139 LEU B CB  1 
ATOM   3267 C  CG  . LEU B 1 139 ? -13.161 9.622   12.661  1.00 11.01 ? 139 LEU B CG  1 
ATOM   3268 C  CD1 . LEU B 1 139 ? -11.978 9.826   11.683  1.00 14.03 ? 139 LEU B CD1 1 
ATOM   3269 C  CD2 . LEU B 1 139 ? -14.489 9.973   11.938  1.00 12.70 ? 139 LEU B CD2 1 
ATOM   3270 N  N   . ALA B 1 140 ? -14.681 5.678   14.134  1.00 8.26  ? 140 ALA B N   1 
ATOM   3271 C  CA  . ALA B 1 140 ? -14.457 4.198   14.324  1.00 8.15  ? 140 ALA B CA  1 
ATOM   3272 C  C   . ALA B 1 140 ? -14.363 3.619   12.922  1.00 7.70  ? 140 ALA B C   1 
ATOM   3273 O  O   . ALA B 1 140 ? -15.285 3.817   12.106  1.00 8.33  ? 140 ALA B O   1 
ATOM   3274 C  CB  . ALA B 1 140 ? -15.647 3.543   15.062  1.00 9.50  ? 140 ALA B CB  1 
ATOM   3275 N  N   . VAL B 1 141 ? -13.235 2.951   12.638  1.00 6.59  ? 141 VAL B N   1 
ATOM   3276 C  CA  . VAL B 1 141 ? -13.081 2.353   11.311  1.00 5.94  ? 141 VAL B CA  1 
ATOM   3277 C  C   . VAL B 1 141 ? -13.086 0.824   11.456  1.00 6.25  ? 141 VAL B C   1 
ATOM   3278 O  O   . VAL B 1 141 ? -12.414 0.282   12.323  1.00 6.69  ? 141 VAL B O   1 
ATOM   3279 C  CB  . VAL B 1 141 ? -11.785 2.834   10.658  1.00 5.48  ? 141 VAL B CB  1 
ATOM   3280 C  CG1 . VAL B 1 141 ? -11.612 2.158   9.270   1.00 6.86  ? 141 VAL B CG1 1 
ATOM   3281 C  CG2 . VAL B 1 141 ? -11.850 4.367   10.491  1.00 6.73  ? 141 VAL B CG2 1 
ATOM   3282 N  N   . LEU B 1 142 ? -13.863 0.186   10.617  1.00 5.79  ? 142 LEU B N   1 
ATOM   3283 C  CA  . LEU B 1 142 ? -13.843 -1.274  10.504  1.00 5.74  ? 142 LEU B CA  1 
ATOM   3284 C  C   . LEU B 1 142 ? -12.880 -1.603  9.393   1.00 6.03  ? 142 LEU B C   1 
ATOM   3285 O  O   . LEU B 1 142 ? -12.984 -1.101  8.279   1.00 7.46  ? 142 LEU B O   1 
ATOM   3286 C  CB  . LEU B 1 142 ? -15.161 -1.839  10.202  1.00 5.86  ? 142 LEU B CB  1 
ATOM   3287 C  CG  . LEU B 1 142 ? -16.342 -1.489  11.088  1.00 6.73  ? 142 LEU B CG  1 
ATOM   3288 C  CD1 . LEU B 1 142 ? -17.572 -2.213  10.552  1.00 8.84  ? 142 LEU B CD1 1 
ATOM   3289 C  CD2 . LEU B 1 142 ? -16.079 -1.862  12.544  1.00 8.84  ? 142 LEU B CD2 1 
ATOM   3290 N  N   . ALA B 1 143 ? -11.931 -2.547  9.637   1.00 5.03  ? 143 ALA B N   1 
ATOM   3291 C  CA  . ALA B 1 143 ? -10.992 -2.988  8.585   1.00 4.66  ? 143 ALA B CA  1 
ATOM   3292 C  C   . ALA B 1 143 ? -11.152 -4.445  8.285   1.00 4.39  ? 143 ALA B C   1 
ATOM   3293 O  O   . ALA B 1 143 ? -11.223 -5.287  9.215   1.00 5.25  ? 143 ALA B O   1 
ATOM   3294 C  CB  . ALA B 1 143 ? -9.574  -2.716  9.068   1.00 5.87  ? 143 ALA B CB  1 
ATOM   3295 N  N   . VAL B 1 144 ? -11.280 -4.721  6.991   1.00 4.35  ? 144 VAL B N   1 
ATOM   3296 C  CA  . VAL B 1 144 ? -11.374 -6.094  6.454   1.00 4.69  ? 144 VAL B CA  1 
ATOM   3297 C  C   . VAL B 1 144 ? -10.164 -6.363  5.631   1.00 4.89  ? 144 VAL B C   1 
ATOM   3298 O  O   . VAL B 1 144 ? -9.827  -5.619  4.696   1.00 5.12  ? 144 VAL B O   1 
ATOM   3299 C  CB  . VAL B 1 144 ? -12.624 -6.282  5.588   1.00 5.33  ? 144 VAL B CB  1 
ATOM   3300 C  CG1 . VAL B 1 144 ? -12.661 -7.722  5.134   1.00 6.42  ? 144 VAL B CG1 1 
ATOM   3301 C  CG2 . VAL B 1 144 ? -13.852 -5.913  6.395   1.00 6.17  ? 144 VAL B CG2 1 
ATOM   3302 N  N   . LEU B 1 145 ? -9.383  -7.363  6.041   1.00 4.97  ? 145 LEU B N   1 
ATOM   3303 C  CA  . LEU B 1 145 ? -8.190  -7.795  5.330   1.00 6.12  ? 145 LEU B CA  1 
ATOM   3304 C  C   . LEU B 1 145 ? -8.645  -8.612  4.139   1.00 5.16  ? 145 LEU B C   1 
ATOM   3305 O  O   . LEU B 1 145 ? -9.626  -9.426  4.240   1.00 5.73  ? 145 LEU B O   1 
ATOM   3306 C  CB  . LEU B 1 145 ? -7.301  -8.660  6.239   1.00 7.31  ? 145 LEU B CB  1 
ATOM   3307 C  CG  . LEU B 1 145 ? -6.854  -7.900  7.499   1.00 8.56  ? 145 LEU B CG  1 
ATOM   3308 C  CD1 . LEU B 1 145 ? -6.209  -8.883  8.505   1.00 11.50 ? 145 LEU B CD1 1 
ATOM   3309 C  CD2 . LEU B 1 145 ? -5.788  -6.897  7.056   1.00 11.36 ? 145 LEU B CD2 1 
ATOM   3310 N  N   . ILE B 1 146 ? -8.030  -8.385  2.970   1.00 5.77  ? 146 ILE B N   1 
ATOM   3311 C  CA  . ILE B 1 146 ? -8.457  -9.056  1.735   1.00 5.75  ? 146 ILE B CA  1 
ATOM   3312 C  C   . ILE B 1 146 ? -7.308  -9.864  1.191   1.00 6.17  ? 146 ILE B C   1 
ATOM   3313 O  O   . ILE B 1 146 ? -6.206  -9.370  1.000   1.00 6.39  ? 146 ILE B O   1 
ATOM   3314 C  CB  . ILE B 1 146 ? -8.821  -7.942  0.714   1.00 5.58  ? 146 ILE B CB  1 
ATOM   3315 C  CG1 . ILE B 1 146 ? -10.060 -7.192  1.207   1.00 5.67  ? 146 ILE B CG1 1 
ATOM   3316 C  CG2 . ILE B 1 146 ? -9.182  -8.661  -0.626  1.00 6.35  ? 146 ILE B CG2 1 
ATOM   3317 C  CD1 . ILE B 1 146 ? -10.370 -5.937  0.368   1.00 6.65  ? 146 ILE B CD1 1 
ATOM   3318 N  N   . GLU B 1 147 ? -7.594  -11.148 0.919   1.00 7.45  ? 147 GLU B N   1 
ATOM   3319 C  CA  . GLU B 1 147 ? -6.574  -12.015 0.344   1.00 8.45  ? 147 GLU B CA  1 
ATOM   3320 C  C   . GLU B 1 147 ? -6.982  -12.410 -1.077  1.00 7.19  ? 147 GLU B C   1 
ATOM   3321 O  O   . GLU B 1 147 ? -8.178  -12.401 -1.423  1.00 7.64  ? 147 GLU B O   1 
ATOM   3322 C  CB  . GLU B 1 147 ? -6.302  -13.260 1.216   1.00 12.86 ? 147 GLU B CB  1 
ATOM   3323 C  CG  . GLU B 1 147 ? -7.436  -14.274 1.313   1.00 18.08 ? 147 GLU B CG  1 
ATOM   3324 C  CD  . GLU B 1 147 ? -7.183  -15.354 2.357   1.00 22.32 ? 147 GLU B CD  1 
ATOM   3325 O  OE1 . GLU B 1 147 ? -6.146  -15.288 3.057   1.00 22.43 ? 147 GLU B OE1 1 
ATOM   3326 O  OE2 . GLU B 1 147 ? -8.015  -16.274 2.487   1.00 28.45 ? 147 GLU B OE2 1 
ATOM   3327 N  N   . MET B 1 148 ? -5.997  -12.776 -1.892  1.00 7.07  ? 148 MET B N   1 
ATOM   3328 C  CA  . MET B 1 148 ? -6.287  -13.303 -3.197  1.00 8.02  ? 148 MET B CA  1 
ATOM   3329 C  C   . MET B 1 148 ? -6.891  -14.701 -3.070  1.00 8.11  ? 148 MET B C   1 
ATOM   3330 O  O   . MET B 1 148 ? -6.293  -15.589 -2.446  1.00 9.14  ? 148 MET B O   1 
ATOM   3331 C  CB  . MET B 1 148 ? -4.966  -13.432 -4.007  1.00 8.60  ? 148 MET B CB  1 
ATOM   3332 C  CG  . MET B 1 148 ? -5.260  -13.728 -5.477  1.00 9.82  ? 148 MET B CG  1 
ATOM   3333 S  SD  . MET B 1 148 ? -3.719  -13.813 -6.455  1.00 12.92 ? 148 MET B SD  1 
ATOM   3334 C  CE  . MET B 1 148 ? -3.229  -12.086 -6.453  1.00 12.74 ? 148 MET B CE  1 
ATOM   3335 N  N   . GLY B 1 149 ? -8.043  -14.875 -3.735  1.00 7.25  ? 149 GLY B N   1 
ATOM   3336 C  CA  . GLY B 1 149 ? -8.747  -16.156 -3.644  1.00 7.36  ? 149 GLY B CA  1 
ATOM   3337 C  C   . GLY B 1 149 ? -9.865  -16.227 -4.664  1.00 5.91  ? 149 GLY B C   1 
ATOM   3338 O  O   . GLY B 1 149 ? -9.708  -15.941 -5.841  1.00 6.82  ? 149 GLY B O   1 
ATOM   3339 N  N   . SER B 1 150 ? -11.004 -16.655 -4.201  1.00 6.59  ? 150 SER B N   1 
ATOM   3340 C  CA  . SER B 1 150 ? -12.200 -16.721 -5.058  1.00 6.84  ? 150 SER B CA  1 
ATOM   3341 C  C   . SER B 1 150 ? -12.751 -15.353 -5.438  1.00 7.83  ? 150 SER B C   1 
ATOM   3342 O  O   . SER B 1 150 ? -12.655 -14.380 -4.655  1.00 8.43  ? 150 SER B O   1 
ATOM   3343 C  CB  . SER B 1 150 ? -13.292 -17.430 -4.327  1.00 6.86  ? 150 SER B CB  1 
ATOM   3344 O  OG  . SER B 1 150 ? -12.884 -18.828 -4.171  1.00 8.26  ? 150 SER B OG  1 
ATOM   3345 N  N   . PHE B 1 151 ? -13.333 -15.316 -6.643  1.00 7.70  ? 151 PHE B N   1 
ATOM   3346 C  CA  . PHE B 1 151 ? -14.132 -14.188 -7.077  1.00 7.51  ? 151 PHE B CA  1 
ATOM   3347 C  C   . PHE B 1 151 ? -15.150 -13.881 -6.030  1.00 7.83  ? 151 PHE B C   1 
ATOM   3348 O  O   . PHE B 1 151 ? -15.852 -14.729 -5.463  1.00 8.69  ? 151 PHE B O   1 
ATOM   3349 C  CB  . PHE B 1 151 ? -14.808 -14.527 -8.398  1.00 7.97  ? 151 PHE B CB  1 
ATOM   3350 C  CG  . PHE B 1 151 ? -15.624 -13.381 -8.896  1.00 7.99  ? 151 PHE B CG  1 
ATOM   3351 C  CD1 . PHE B 1 151 ? -14.981 -12.303 -9.556  1.00 8.33  ? 151 PHE B CD1 1 
ATOM   3352 C  CD2 . PHE B 1 151 ? -16.994 -13.368 -8.832  1.00 7.89  ? 151 PHE B CD2 1 
ATOM   3353 C  CE1 . PHE B 1 151 ? -15.727 -11.222 -10.035 1.00 8.83  ? 151 PHE B CE1 1 
ATOM   3354 C  CE2 . PHE B 1 151 ? -17.770 -12.226 -9.296  1.00 8.99  ? 151 PHE B CE2 1 
ATOM   3355 C  CZ  . PHE B 1 151 ? -17.062 -11.215 -9.911  1.00 7.83  ? 151 PHE B CZ  1 
ATOM   3356 N  N   . ASN B 1 152 ? -15.338 -12.564 -5.758  1.00 6.24  ? 152 ASN B N   1 
ATOM   3357 C  CA  . ASN B 1 152 ? -16.269 -12.117 -4.789  1.00 6.85  ? 152 ASN B CA  1 
ATOM   3358 C  C   . ASN B 1 152 ? -17.324 -11.214 -5.430  1.00 7.24  ? 152 ASN B C   1 
ATOM   3359 O  O   . ASN B 1 152 ? -17.042 -10.045 -5.709  1.00 6.98  ? 152 ASN B O   1 
ATOM   3360 C  CB  . ASN B 1 152 ? -15.454 -11.325 -3.680  1.00 6.15  ? 152 ASN B CB  1 
ATOM   3361 C  CG  . ASN B 1 152 ? -16.290 -11.101 -2.459  1.00 6.15  ? 152 ASN B CG  1 
ATOM   3362 O  OD1 . ASN B 1 152 ? -17.433 -10.590 -2.557  1.00 8.15  ? 152 ASN B OD1 1 
ATOM   3363 N  ND2 . ASN B 1 152 ? -15.743 -11.353 -1.273  1.00 6.96  ? 152 ASN B ND2 1 
ATOM   3364 N  N   . PRO B 1 153 ? -18.528 -11.688 -5.621  1.00 7.91  ? 153 PRO B N   1 
ATOM   3365 C  CA  . PRO B 1 153 ? -19.573 -10.886 -6.322  1.00 8.33  ? 153 PRO B CA  1 
ATOM   3366 C  C   . PRO B 1 153 ? -19.950 -9.679  -5.496  1.00 8.62  ? 153 PRO B C   1 
ATOM   3367 O  O   . PRO B 1 153 ? -20.297 -8.651  -6.097  1.00 9.53  ? 153 PRO B O   1 
ATOM   3368 C  CB  . PRO B 1 153 ? -20.769 -11.885 -6.393  1.00 10.12 ? 153 PRO B CB  1 
ATOM   3369 C  CG  . PRO B 1 153 ? -20.138 -13.235 -6.268  1.00 12.28 ? 153 PRO B CG  1 
ATOM   3370 C  CD  . PRO B 1 153 ? -18.946 -13.114 -5.361  1.00 9.44  ? 153 PRO B CD  1 
ATOM   3371 N  N   . SER B 1 154 ? -19.858 -9.697  -4.175  1.00 8.33  ? 154 SER B N   1 
ATOM   3372 C  CA  . SER B 1 154 ? -20.276 -8.530  -3.389  1.00 8.06  ? 154 SER B CA  1 
ATOM   3373 C  C   . SER B 1 154 ? -19.264 -7.403  -3.578  1.00 7.81  ? 154 SER B C   1 
ATOM   3374 O  O   . SER B 1 154 ? -19.635 -6.236  -3.804  1.00 7.90  ? 154 SER B O   1 
ATOM   3375 C  CB  . SER B 1 154 ? -20.360 -8.845  -1.893  1.00 12.09 ? 154 SER B CB  1 
ATOM   3376 O  OG  . SER B 1 154 ? -21.306 -9.885  -1.744  1.00 15.41 ? 154 SER B OG  1 
ATOM   3377 N  N   . TYR B 1 155 ? -17.940 -7.679  -3.521  1.00 6.38  ? 155 TYR B N   1 
ATOM   3378 C  CA  . TYR B 1 155 ? -16.953 -6.665  -3.814  1.00 6.68  ? 155 TYR B CA  1 
ATOM   3379 C  C   . TYR B 1 155 ? -17.107 -6.203  -5.247  1.00 6.93  ? 155 TYR B C   1 
ATOM   3380 O  O   . TYR B 1 155 ? -16.784 -5.012  -5.524  1.00 6.85  ? 155 TYR B O   1 
ATOM   3381 C  CB  . TYR B 1 155 ? -15.515 -7.179  -3.520  1.00 6.42  ? 155 TYR B CB  1 
ATOM   3382 C  CG  . TYR B 1 155 ? -15.186 -7.028  -2.057  1.00 6.17  ? 155 TYR B CG  1 
ATOM   3383 C  CD1 . TYR B 1 155 ? -14.423 -5.927  -1.597  1.00 6.56  ? 155 TYR B CD1 1 
ATOM   3384 C  CD2 . TYR B 1 155 ? -15.577 -7.966  -1.079  1.00 6.14  ? 155 TYR B CD2 1 
ATOM   3385 C  CE1 . TYR B 1 155 ? -14.115 -5.818  -0.237  1.00 7.45  ? 155 TYR B CE1 1 
ATOM   3386 C  CE2 . TYR B 1 155 ? -15.331 -7.790  0.264   1.00 6.74  ? 155 TYR B CE2 1 
ATOM   3387 C  CZ  . TYR B 1 155 ? -14.579 -6.727  0.680   1.00 6.72  ? 155 TYR B CZ  1 
ATOM   3388 O  OH  . TYR B 1 155 ? -14.288 -6.592  2.015   1.00 7.51  ? 155 TYR B OH  1 
ATOM   3389 N  N   . ASP B 1 156 ? -17.556 -7.043  -6.129  1.00 7.15  ? 156 ASP B N   1 
ATOM   3390 C  CA  . ASP B 1 156 ? -17.667 -6.617  -7.496  1.00 7.60  ? 156 ASP B CA  1 
ATOM   3391 C  C   . ASP B 1 156 ? -18.739 -5.589  -7.666  1.00 7.60  ? 156 ASP B C   1 
ATOM   3392 O  O   . ASP B 1 156 ? -18.650 -4.831  -8.701  1.00 8.03  ? 156 ASP B O   1 
ATOM   3393 C  CB  . ASP B 1 156 ? -17.803 -7.779  -8.485  1.00 8.98  ? 156 ASP B CB  1 
ATOM   3394 C  CG  . ASP B 1 156 ? -16.856 -7.636  -9.671  1.00 9.52  ? 156 ASP B CG  1 
ATOM   3395 O  OD1 . ASP B 1 156 ? -15.640 -7.463  -9.442  1.00 8.76  ? 156 ASP B OD1 1 
ATOM   3396 O  OD2 . ASP B 1 156 ? -17.323 -7.675  -10.829 1.00 14.72 ? 156 ASP B OD2 1 
ATOM   3397 N  N   . LYS B 1 157 ? -19.685 -5.504  -6.774  1.00 8.31  ? 157 LYS B N   1 
ATOM   3398 C  CA  . LYS B 1 157 ? -20.715 -4.436  -6.839  1.00 9.75  ? 157 LYS B CA  1 
ATOM   3399 C  C   . LYS B 1 157 ? -19.986 -3.102  -6.773  1.00 9.68  ? 157 LYS B C   1 
ATOM   3400 O  O   . LYS B 1 157 ? -20.533 -2.122  -7.342  1.00 10.92 ? 157 LYS B O   1 
ATOM   3401 C  CB  . LYS B 1 157 ? -21.747 -4.585  -5.740  1.00 10.24 ? 157 LYS B CB  1 
ATOM   3402 C  CG  . LYS B 1 157 ? -22.499 -5.942  -5.945  1.00 12.44 ? 157 LYS B CG  1 
ATOM   3403 C  CD  . LYS B 1 157 ? -23.409 -6.271  -4.797  1.00 14.67 ? 157 LYS B CD  1 
ATOM   3404 C  CE  . LYS B 1 157 ? -24.244 -7.519  -5.154  1.00 19.88 ? 157 LYS B CE  1 
ATOM   3405 N  NZ  . LYS B 1 157 ? -24.978 -8.031  -3.916  1.00 21.25 ? 157 LYS B NZ  1 
ATOM   3406 N  N   . ILE B 1 158 ? -18.850 -2.988  -6.094  1.00 7.90  ? 158 ILE B N   1 
ATOM   3407 C  CA  . ILE B 1 158 ? -18.082 -1.741  -6.120  1.00 8.64  ? 158 ILE B CA  1 
ATOM   3408 C  C   . ILE B 1 158 ? -17.141 -1.742  -7.271  1.00 8.92  ? 158 ILE B C   1 
ATOM   3409 O  O   . ILE B 1 158 ? -17.056 -0.759  -8.058  1.00 8.91  ? 158 ILE B O   1 
ATOM   3410 C  CB  . ILE B 1 158 ? -17.271 -1.610  -4.796  1.00 9.03  ? 158 ILE B CB  1 
ATOM   3411 C  CG1 . ILE B 1 158 ? -18.252 -1.458  -3.626  1.00 11.95 ? 158 ILE B CG1 1 
ATOM   3412 C  CG2 . ILE B 1 158 ? -16.298 -0.374  -4.874  1.00 10.14 ? 158 ILE B CG2 1 
ATOM   3413 C  CD1 . ILE B 1 158 ? -17.572 -1.764  -2.283  1.00 14.83 ? 158 ILE B CD1 1 
ATOM   3414 N  N   . PHE B 1 159 ? -16.365 -2.836  -7.491  1.00 7.83  ? 159 PHE B N   1 
ATOM   3415 C  CA  . PHE B 1 159 ? -15.257 -2.788  -8.395  1.00 9.90  ? 159 PHE B CA  1 
ATOM   3416 C  C   . PHE B 1 159 ? -15.737 -2.607  -9.779  1.00 10.50 ? 159 PHE B C   1 
ATOM   3417 O  O   . PHE B 1 159 ? -14.976 -2.037  -10.570 1.00 14.25 ? 159 PHE B O   1 
ATOM   3418 C  CB  . PHE B 1 159 ? -14.508 -4.109  -8.369  1.00 9.80  ? 159 PHE B CB  1 
ATOM   3419 C  CG  . PHE B 1 159 ? -13.812 -4.373  -7.065  1.00 10.52 ? 159 PHE B CG  1 
ATOM   3420 C  CD1 . PHE B 1 159 ? -13.459 -3.340  -6.173  1.00 11.87 ? 159 PHE B CD1 1 
ATOM   3421 C  CD2 . PHE B 1 159 ? -13.429 -5.714  -6.771  1.00 11.77 ? 159 PHE B CD2 1 
ATOM   3422 C  CE1 . PHE B 1 159 ? -12.773 -3.670  -5.016  1.00 12.65 ? 159 PHE B CE1 1 
ATOM   3423 C  CE2 . PHE B 1 159 ? -12.768 -5.977  -5.624  1.00 11.51 ? 159 PHE B CE2 1 
ATOM   3424 C  CZ  . PHE B 1 159 ? -12.371 -4.942  -4.769  1.00 11.91 ? 159 PHE B CZ  1 
ATOM   3425 N  N   . SER B 1 160 ? -16.886 -3.111  -10.129 1.00 10.14 ? 160 SER B N   1 
ATOM   3426 C  CA  . SER B 1 160 ? -17.406 -2.973  -11.537 1.00 11.90 ? 160 SER B CA  1 
ATOM   3427 C  C   . SER B 1 160 ? -17.681 -1.529  -11.926 1.00 11.54 ? 160 SER B C   1 
ATOM   3428 O  O   . SER B 1 160 ? -17.938 -1.306  -13.107 1.00 13.78 ? 160 SER B O   1 
ATOM   3429 C  CB  . SER B 1 160 ? -18.627 -3.894  -11.695 1.00 14.70 ? 160 SER B CB  1 
ATOM   3430 O  OG  . SER B 1 160 ? -19.714 -3.414  -10.949 1.00 13.38 ? 160 SER B OG  1 
ATOM   3431 N  N   . HIS B 1 161 ? -17.610 -0.575  -10.994 1.00 10.44 ? 161 HIS B N   1 
ATOM   3432 C  CA  . HIS B 1 161 ? -17.775 0.872   -11.280 1.00 11.33 ? 161 HIS B CA  1 
ATOM   3433 C  C   . HIS B 1 161 ? -16.501 1.662   -11.278 1.00 12.41 ? 161 HIS B C   1 
ATOM   3434 O  O   . HIS B 1 161 ? -16.545 2.821   -11.632 1.00 13.57 ? 161 HIS B O   1 
ATOM   3435 C  CB  . HIS B 1 161 ? -18.735 1.510   -10.337 1.00 11.79 ? 161 HIS B CB  1 
ATOM   3436 C  CG  . HIS B 1 161 ? -20.076 0.935   -10.384 1.00 12.45 ? 161 HIS B CG  1 
ATOM   3437 N  ND1 . HIS B 1 161 ? -20.972 1.379   -11.329 1.00 14.16 ? 161 HIS B ND1 1 
ATOM   3438 C  CD2 . HIS B 1 161 ? -20.695 -0.111  -9.672  1.00 13.57 ? 161 HIS B CD2 1 
ATOM   3439 C  CE1 . HIS B 1 161 ? -22.144 0.740   -11.145 1.00 14.65 ? 161 HIS B CE1 1 
ATOM   3440 N  NE2 . HIS B 1 161 ? -21.947 -0.248  -10.160 1.00 14.43 ? 161 HIS B NE2 1 
ATOM   3441 N  N   . LEU B 1 162 ? -15.392 1.101   -10.854 1.00 14.28 ? 162 LEU B N   1 
ATOM   3442 C  CA  . LEU B 1 162 ? -14.154 1.888   -10.679 1.00 15.06 ? 162 LEU B CA  1 
ATOM   3443 C  C   . LEU B 1 162 ? -13.635 2.399   -11.997 1.00 20.16 ? 162 LEU B C   1 
ATOM   3444 O  O   . LEU B 1 162 ? -13.135 3.548   -12.054 1.00 16.61 ? 162 LEU B O   1 
ATOM   3445 C  CB  . LEU B 1 162 ? -13.111 1.018   -9.951  1.00 18.16 ? 162 LEU B CB  1 
ATOM   3446 C  CG  . LEU B 1 162 ? -13.334 0.676   -8.506  1.00 19.34 ? 162 LEU B CG  1 
ATOM   3447 C  CD1 . LEU B 1 162 ? -12.133 -0.167  -8.047  1.00 23.87 ? 162 LEU B CD1 1 
ATOM   3448 C  CD2 . LEU B 1 162 ? -13.617 1.790   -7.520  1.00 17.59 ? 162 LEU B CD2 1 
ATOM   3449 N  N   . GLN B 1 163 ? -13.716 1.616   -13.054 1.00 19.11 ? 163 GLN B N   1 
ATOM   3450 C  CA  . GLN B 1 163 ? -13.284 2.094   -14.382 1.00 20.16 ? 163 GLN B CA  1 
ATOM   3451 C  C   . GLN B 1 163 ? -14.067 3.363   -14.852 1.00 20.25 ? 163 GLN B C   1 
ATOM   3452 O  O   . GLN B 1 163 ? -13.733 4.016   -15.839 1.00 29.67 ? 163 GLN B O   1 
ATOM   3453 C  CB  . GLN B 1 163 ? -13.145 0.941   -15.376 1.00 24.63 ? 163 GLN B CB  1 
ATOM   3454 C  CG  . GLN B 1 163 ? -14.506 0.418   -15.783 1.00 21.68 ? 163 GLN B CG  1 
ATOM   3455 C  CD  . GLN B 1 163 ? -15.145 -0.630  -14.840 1.00 24.13 ? 163 GLN B CD  1 
ATOM   3456 O  OE1 . GLN B 1 163 ? -14.869 -0.691  -13.606 1.00 22.12 ? 163 GLN B OE1 1 
ATOM   3457 N  NE2 . GLN B 1 163 ? -15.931 -1.515  -15.427 1.00 25.23 ? 163 GLN B NE2 1 
ATOM   3458 N  N   . HIS B 1 164 ? -15.093 3.744   -14.097 1.00 15.55 ? 164 HIS B N   1 
ATOM   3459 C  CA  . HIS B 1 164 ? -15.924 4.892   -14.354 1.00 12.37 ? 164 HIS B CA  1 
ATOM   3460 C  C   . HIS B 1 164 ? -15.640 6.133   -13.470 1.00 13.25 ? 164 HIS B C   1 
ATOM   3461 O  O   . HIS B 1 164 ? -16.223 7.208   -13.469 1.00 12.70 ? 164 HIS B O   1 
ATOM   3462 C  CB  . HIS B 1 164 ? -17.391 4.438   -14.412 1.00 16.94 ? 164 HIS B CB  1 
ATOM   3463 C  CG  . HIS B 1 164 ? -17.593 3.263   -15.379 1.00 15.79 ? 164 HIS B CG  1 
ATOM   3464 N  ND1 . HIS B 1 164 ? -17.189 3.303   -16.688 1.00 20.09 ? 164 HIS B ND1 1 
ATOM   3465 C  CD2 . HIS B 1 164 ? -18.166 1.983   -15.175 1.00 19.72 ? 164 HIS B CD2 1 
ATOM   3466 C  CE1 . HIS B 1 164 ? -17.495 2.117   -17.297 1.00 21.07 ? 164 HIS B CE1 1 
ATOM   3467 N  NE2 . HIS B 1 164 ? -18.075 1.305   -16.373 1.00 17.21 ? 164 HIS B NE2 1 
ATOM   3468 N  N   . VAL B 1 165 ? -14.658 5.946   -12.563 1.00 9.80  ? 165 VAL B N   1 
ATOM   3469 C  CA  . VAL B 1 165 ? -14.145 6.990   -11.719 1.00 9.11  ? 165 VAL B CA  1 
ATOM   3470 C  C   . VAL B 1 165 ? -12.637 6.933   -11.823 1.00 7.29  ? 165 VAL B C   1 
ATOM   3471 O  O   . VAL B 1 165 ? -11.893 7.093   -10.854 1.00 8.81  ? 165 VAL B O   1 
ATOM   3472 C  CB  . VAL B 1 165 ? -14.674 6.953   -10.280 1.00 9.85  ? 165 VAL B CB  1 
ATOM   3473 C  CG1 . VAL B 1 165 ? -16.159 7.239   -10.287 1.00 11.98 ? 165 VAL B CG1 1 
ATOM   3474 C  CG2 . VAL B 1 165 ? -14.406 5.683   -9.555  1.00 11.09 ? 165 VAL B CG2 1 
ATOM   3475 N  N   A LYS B 1 166 ? -12.136 6.706   -13.016 0.50 7.58  ? 166 LYS B N   1 
ATOM   3476 N  N   B LYS B 1 166 ? -12.231 6.740   -13.042 0.50 6.96  ? 166 LYS B N   1 
ATOM   3477 C  CA  A LYS B 1 166 ? -10.704 6.510   -13.180 0.50 8.07  ? 166 LYS B CA  1 
ATOM   3478 C  CA  B LYS B 1 166 ? -10.874 6.528   -13.308 0.50 7.01  ? 166 LYS B CA  1 
ATOM   3479 C  C   A LYS B 1 166 ? -9.872  7.716   -12.722 0.50 6.76  ? 166 LYS B C   1 
ATOM   3480 C  C   B LYS B 1 166 ? -9.949  7.669   -12.886 0.50 6.24  ? 166 LYS B C   1 
ATOM   3481 O  O   A LYS B 1 166 ? -8.767  7.573   -12.161 0.50 6.60  ? 166 LYS B O   1 
ATOM   3482 O  O   B LYS B 1 166 ? -8.834  7.413   -12.543 0.50 6.54  ? 166 LYS B O   1 
ATOM   3483 C  CB  A LYS B 1 166 ? -10.385 6.247   -14.669 0.50 9.11  ? 166 LYS B CB  1 
ATOM   3484 C  CB  B LYS B 1 166 ? -10.746 6.332   -14.817 0.50 6.80  ? 166 LYS B CB  1 
ATOM   3485 C  CG  A LYS B 1 166 ? -10.987 4.996   -15.240 0.50 11.95 ? 166 LYS B CG  1 
ATOM   3486 C  CG  B LYS B 1 166 ? -9.302  6.134   -15.232 0.50 7.28  ? 166 LYS B CG  1 
ATOM   3487 C  CD  A LYS B 1 166 ? -10.509 4.759   -16.659 0.50 12.56 ? 166 LYS B CD  1 
ATOM   3488 C  CD  B LYS B 1 166 ? -9.173  5.778   -16.733 0.50 8.08  ? 166 LYS B CD  1 
ATOM   3489 C  CE  A LYS B 1 166 ? -8.997  4.798   -16.718 0.50 14.15 ? 166 LYS B CE  1 
ATOM   3490 C  CE  B LYS B 1 166 ? -7.766  5.402   -17.143 0.50 8.88  ? 166 LYS B CE  1 
ATOM   3491 N  NZ  A LYS B 1 166 ? -8.652  3.421   -16.321 0.50 14.50 ? 166 LYS B NZ  1 
ATOM   3492 N  NZ  B LYS B 1 166 ? -7.614  5.061   -18.607 0.50 10.84 ? 166 LYS B NZ  1 
ATOM   3493 N  N   . TYR B 1 167 ? -10.408 8.921   -12.895 1.00 6.44  ? 167 TYR B N   1 
ATOM   3494 C  CA  . TYR B 1 167 ? -9.596  10.083  -12.666 1.00 6.61  ? 167 TYR B CA  1 
ATOM   3495 C  C   . TYR B 1 167 ? -10.055 10.926  -11.469 1.00 6.23  ? 167 TYR B C   1 
ATOM   3496 O  O   . TYR B 1 167 ? -11.255 10.875  -11.111 1.00 6.32  ? 167 TYR B O   1 
ATOM   3497 C  CB  . TYR B 1 167 ? -9.573  11.010  -13.933 1.00 7.53  ? 167 TYR B CB  1 
ATOM   3498 C  CG  . TYR B 1 167 ? -9.095  10.277  -15.168 1.00 7.79  ? 167 TYR B CG  1 
ATOM   3499 C  CD1 . TYR B 1 167 ? -7.765  9.947   -15.318 1.00 9.76  ? 167 TYR B CD1 1 
ATOM   3500 C  CD2 . TYR B 1 167 ? -10.005 9.879   -16.118 1.00 8.48  ? 167 TYR B CD2 1 
ATOM   3501 C  CE1 . TYR B 1 167 ? -7.328  9.253   -16.465 1.00 8.90  ? 167 TYR B CE1 1 
ATOM   3502 C  CE2 . TYR B 1 167 ? -9.605  9.175   -17.225 1.00 9.53  ? 167 TYR B CE2 1 
ATOM   3503 C  CZ  . TYR B 1 167 ? -8.301  8.914   -17.386 1.00 10.86 ? 167 TYR B CZ  1 
ATOM   3504 O  OH  . TYR B 1 167 ? -7.901  8.197   -18.542 1.00 12.68 ? 167 TYR B OH  1 
ATOM   3505 N  N   . LYS B 1 168 ? -9.122  11.654  -10.895 1.00 6.39  ? 168 LYS B N   1 
ATOM   3506 C  CA  . LYS B 1 168 ? -9.457  12.571  -9.803  1.00 7.95  ? 168 LYS B CA  1 
ATOM   3507 C  C   . LYS B 1 168 ? -10.632 13.437  -10.121 1.00 7.70  ? 168 LYS B C   1 
ATOM   3508 O  O   . LYS B 1 168 ? -10.725 14.023  -11.169 1.00 9.32  ? 168 LYS B O   1 
ATOM   3509 C  CB  . LYS B 1 168 ? -8.233  13.464  -9.526  1.00 8.46  ? 168 LYS B CB  1 
ATOM   3510 C  CG  . LYS B 1 168 ? -8.503  14.354  -8.332  1.00 10.67 ? 168 LYS B CG  1 
ATOM   3511 C  CD  . LYS B 1 168 ? -7.246  15.201  -8.060  1.00 14.66 ? 168 LYS B CD  1 
ATOM   3512 C  CE  . LYS B 1 168 ? -7.589  16.160  -6.934  1.00 19.69 ? 168 LYS B CE  1 
ATOM   3513 N  NZ  . LYS B 1 168 ? -6.497  17.197  -6.774  1.00 24.64 ? 168 LYS B NZ  1 
ATOM   3514 N  N   . GLY B 1 169 ? -11.569 13.505  -9.178  1.00 8.68  ? 169 GLY B N   1 
ATOM   3515 C  CA  . GLY B 1 169 ? -12.762 14.339  -9.319  1.00 10.65 ? 169 GLY B CA  1 
ATOM   3516 C  C   . GLY B 1 169 ? -13.967 13.678  -9.910  1.00 12.38 ? 169 GLY B C   1 
ATOM   3517 O  O   . GLY B 1 169 ? -15.083 14.241  -9.897  1.00 14.89 ? 169 GLY B O   1 
ATOM   3518 N  N   . GLN B 1 170 ? -13.757 12.517  -10.493 1.00 9.01  ? 170 GLN B N   1 
ATOM   3519 C  CA  . GLN B 1 170 ? -14.845 11.808  -11.144 1.00 9.29  ? 170 GLN B CA  1 
ATOM   3520 C  C   . GLN B 1 170 ? -15.732 11.137  -10.089 1.00 10.21 ? 170 GLN B C   1 
ATOM   3521 O  O   . GLN B 1 170 ? -15.289 10.719  -9.017  1.00 10.20 ? 170 GLN B O   1 
ATOM   3522 C  CB  . GLN B 1 170 ? -14.325 10.817  -12.172 1.00 8.95  ? 170 GLN B CB  1 
ATOM   3523 C  CG  . GLN B 1 170 ? -13.656 11.593  -13.351 1.00 9.72  ? 170 GLN B CG  1 
ATOM   3524 C  CD  . GLN B 1 170 ? -13.385 10.673  -14.503 1.00 11.56 ? 170 GLN B CD  1 
ATOM   3525 O  OE1 . GLN B 1 170 ? -12.995 9.526   -14.365 1.00 10.71 ? 170 GLN B OE1 1 
ATOM   3526 N  NE2 . GLN B 1 170 ? -13.623 11.184  -15.743 1.00 15.36 ? 170 GLN B NE2 1 
ATOM   3527 N  N   . GLU B 1 171 ? -17.004 11.002  -10.409 1.00 10.69 ? 171 GLU B N   1 
ATOM   3528 C  CA  . GLU B 1 171 ? -18.014 10.435  -9.547  1.00 11.00 ? 171 GLU B CA  1 
ATOM   3529 C  C   . GLU B 1 171 ? -18.941 9.489   -10.376 1.00 11.52 ? 171 GLU B C   1 
ATOM   3530 O  O   . GLU B 1 171 ? -19.188 9.676   -11.611 1.00 12.24 ? 171 GLU B O   1 
ATOM   3531 C  CB  . GLU B 1 171 ? -18.877 11.561  -9.030  1.00 14.45 ? 171 GLU B CB  1 
ATOM   3532 C  CG  . GLU B 1 171 ? -18.207 12.619  -8.158  1.00 18.47 ? 171 GLU B CG  1 
ATOM   3533 C  CD  . GLU B 1 171 ? -19.226 13.692  -7.736  1.00 23.54 ? 171 GLU B CD  1 
ATOM   3534 O  OE1 . GLU B 1 171 ? -20.293 13.812  -8.396  1.00 33.07 ? 171 GLU B OE1 1 
ATOM   3535 O  OE2 . GLU B 1 171 ? -18.972 14.390  -6.746  1.00 33.65 ? 171 GLU B OE2 1 
ATOM   3536 N  N   . ALA B 1 172 ? -19.447 8.453   -9.702  1.00 11.16 ? 172 ALA B N   1 
ATOM   3537 C  CA  . ALA B 1 172 ? -20.348 7.470   -10.254 1.00 11.22 ? 172 ALA B CA  1 
ATOM   3538 C  C   . ALA B 1 172 ? -21.314 7.075   -9.169  1.00 12.97 ? 172 ALA B C   1 
ATOM   3539 O  O   . ALA B 1 172 ? -21.089 7.231   -7.975  1.00 14.04 ? 172 ALA B O   1 
ATOM   3540 C  CB  . ALA B 1 172 ? -19.600 6.292   -10.864 1.00 11.18 ? 172 ALA B CB  1 
ATOM   3541 N  N   . PHE B 1 173 ? -22.448 6.581   -9.557  1.00 11.34 ? 173 PHE B N   1 
ATOM   3542 C  CA  . PHE B 1 173 ? -23.440 5.990   -8.654  1.00 10.29 ? 173 PHE B CA  1 
ATOM   3543 C  C   . PHE B 1 173 ? -23.455 4.494   -8.698  1.00 10.66 ? 173 PHE B C   1 
ATOM   3544 O  O   . PHE B 1 173 ? -23.385 3.857   -9.718  1.00 14.90 ? 173 PHE B O   1 
ATOM   3545 C  CB  . PHE B 1 173 ? -24.823 6.501   -9.126  1.00 13.56 ? 173 PHE B CB  1 
ATOM   3546 C  CG  . PHE B 1 173 ? -25.154 7.840   -8.562  1.00 13.83 ? 173 PHE B CG  1 
ATOM   3547 C  CD1 . PHE B 1 173 ? -25.190 8.037   -7.193  1.00 16.31 ? 173 PHE B CD1 1 
ATOM   3548 C  CD2 . PHE B 1 173 ? -25.406 8.930   -9.423  1.00 16.95 ? 173 PHE B CD2 1 
ATOM   3549 C  CE1 . PHE B 1 173 ? -25.528 9.240   -6.639  1.00 18.33 ? 173 PHE B CE1 1 
ATOM   3550 C  CE2 . PHE B 1 173 ? -25.680 10.173  -8.863  1.00 18.58 ? 173 PHE B CE2 1 
ATOM   3551 C  CZ  . PHE B 1 173 ? -25.753 10.342  -7.464  1.00 21.52 ? 173 PHE B CZ  1 
ATOM   3552 N  N   . VAL B 1 174 ? -23.483 3.961   -7.475  1.00 10.44 ? 174 VAL B N   1 
ATOM   3553 C  CA  . VAL B 1 174 ? -23.473 2.494   -7.198  1.00 10.07 ? 174 VAL B CA  1 
ATOM   3554 C  C   . VAL B 1 174 ? -24.846 2.151   -6.568  1.00 9.61  ? 174 VAL B C   1 
ATOM   3555 O  O   . VAL B 1 174 ? -25.185 2.676   -5.573  1.00 10.10 ? 174 VAL B O   1 
ATOM   3556 C  CB  . VAL B 1 174 ? -22.313 2.077   -6.244  1.00 9.53  ? 174 VAL B CB  1 
ATOM   3557 C  CG1 . VAL B 1 174 ? -22.344 0.578   -5.922  1.00 12.48 ? 174 VAL B CG1 1 
ATOM   3558 C  CG2 . VAL B 1 174 ? -20.942 2.450   -6.921  1.00 11.64 ? 174 VAL B CG2 1 
ATOM   3559 N  N   . PRO B 1 175 ? -25.600 1.219   -7.196  1.00 9.96  ? 175 PRO B N   1 
ATOM   3560 C  CA  . PRO B 1 175 ? -26.884 0.833   -6.541  1.00 10.08 ? 175 PRO B CA  1 
ATOM   3561 C  C   . PRO B 1 175 ? -26.583 0.224   -5.121  1.00 10.68 ? 175 PRO B C   1 
ATOM   3562 O  O   . PRO B 1 175 ? -25.573 -0.449  -4.879  1.00 10.19 ? 175 PRO B O   1 
ATOM   3563 C  CB  . PRO B 1 175 ? -27.406 -0.259  -7.450  1.00 11.48 ? 175 PRO B CB  1 
ATOM   3564 C  CG  . PRO B 1 175 ? -26.801 -0.021  -8.795  1.00 12.77 ? 175 PRO B CG  1 
ATOM   3565 C  CD  . PRO B 1 175 ? -25.382 0.565   -8.478  1.00 11.59 ? 175 PRO B CD  1 
ATOM   3566 N  N   . GLY B 1 176 ? -27.502 0.413   -4.188  1.00 10.15 ? 176 GLY B N   1 
ATOM   3567 C  CA  . GLY B 1 176 ? -27.344 -0.143  -2.869  1.00 10.59 ? 176 GLY B CA  1 
ATOM   3568 C  C   . GLY B 1 176 ? -27.291 -1.661  -2.934  1.00 10.05 ? 176 GLY B C   1 
ATOM   3569 O  O   . GLY B 1 176 ? -27.849 -2.340  -3.793  1.00 11.10 ? 176 GLY B O   1 
ATOM   3570 N  N   . PHE B 1 177 ? -26.521 -2.108  -1.964  1.00 10.09 ? 177 PHE B N   1 
ATOM   3571 C  CA  . PHE B 1 177 ? -26.424 -3.556  -1.694  1.00 10.20 ? 177 PHE B CA  1 
ATOM   3572 C  C   . PHE B 1 177 ? -26.115 -3.704  -0.233  1.00 9.59  ? 177 PHE B C   1 
ATOM   3573 O  O   . PHE B 1 177 ? -25.985 -2.745  0.516   1.00 9.59  ? 177 PHE B O   1 
ATOM   3574 C  CB  . PHE B 1 177 ? -25.384 -4.232  -2.600  1.00 11.35 ? 177 PHE B CB  1 
ATOM   3575 C  CG  . PHE B 1 177 ? -23.951 -3.817  -2.329  1.00 10.85 ? 177 PHE B CG  1 
ATOM   3576 C  CD1 . PHE B 1 177 ? -23.131 -4.669  -1.556  1.00 10.60 ? 177 PHE B CD1 1 
ATOM   3577 C  CD2 . PHE B 1 177 ? -23.434 -2.659  -2.896  1.00 9.92  ? 177 PHE B CD2 1 
ATOM   3578 C  CE1 . PHE B 1 177 ? -21.807 -4.282  -1.307  1.00 9.59  ? 177 PHE B CE1 1 
ATOM   3579 C  CE2 . PHE B 1 177 ? -22.089 -2.264  -2.680  1.00 11.20 ? 177 PHE B CE2 1 
ATOM   3580 C  CZ  . PHE B 1 177 ? -21.318 -3.108  -1.878  1.00 11.23 ? 177 PHE B CZ  1 
ATOM   3581 N  N   . ASN B 1 178 ? -26.155 -4.970  0.189   1.00 10.79 ? 178 ASN B N   1 
ATOM   3582 C  CA  . ASN B 1 178 ? -25.939 -5.222  1.585   1.00 11.01 ? 178 ASN B CA  1 
ATOM   3583 C  C   . ASN B 1 178 ? -24.410 -5.178  1.905   1.00 9.45  ? 178 ASN B C   1 
ATOM   3584 O  O   . ASN B 1 178 ? -23.646 -6.066  1.558   1.00 10.27 ? 178 ASN B O   1 
ATOM   3585 C  CB  . ASN B 1 178 ? -26.541 -6.604  1.965   1.00 12.69 ? 178 ASN B CB  1 
ATOM   3586 C  CG  . ASN B 1 178 ? -26.359 -6.897  3.344   1.00 13.51 ? 178 ASN B CG  1 
ATOM   3587 O  OD1 . ASN B 1 178 ? -26.022 -6.097  4.254   1.00 11.67 ? 178 ASN B OD1 1 
ATOM   3588 N  ND2 . ASN B 1 178 ? -26.668 -8.215  3.613   1.00 16.87 ? 178 ASN B ND2 1 
ATOM   3589 N  N   . ILE B 1 179 ? -24.032 -4.104  2.550   1.00 8.79  ? 179 ILE B N   1 
ATOM   3590 C  CA  . ILE B 1 179 ? -22.615 -3.852  2.937   1.00 9.49  ? 179 ILE B CA  1 
ATOM   3591 C  C   . ILE B 1 179 ? -22.109 -4.932  3.802   1.00 9.54  ? 179 ILE B C   1 
ATOM   3592 O  O   . ILE B 1 179 ? -20.876 -5.197  3.845   1.00 8.89  ? 179 ILE B O   1 
ATOM   3593 C  CB  . ILE B 1 179 ? -22.493 -2.464  3.522   1.00 9.12  ? 179 ILE B CB  1 
ATOM   3594 C  CG1 . ILE B 1 179 ? -23.021 -1.352  2.574   1.00 9.43  ? 179 ILE B CG1 1 
ATOM   3595 C  CG2 . ILE B 1 179 ? -21.017 -2.206  3.882   1.00 9.63  ? 179 ILE B CG2 1 
ATOM   3596 C  CD1 . ILE B 1 179 ? -22.401 -1.358  1.135   1.00 10.70 ? 179 ILE B CD1 1 
ATOM   3597 N  N   . GLU B 1 180 ? -22.961 -5.590  4.572   1.00 10.65 ? 180 GLU B N   1 
ATOM   3598 C  CA  . GLU B 1 180 ? -22.449 -6.682  5.389   1.00 11.48 ? 180 GLU B CA  1 
ATOM   3599 C  C   . GLU B 1 180 ? -21.887 -7.825  4.601   1.00 10.00 ? 180 GLU B C   1 
ATOM   3600 O  O   . GLU B 1 180 ? -21.064 -8.574  5.166   1.00 11.82 ? 180 GLU B O   1 
ATOM   3601 C  CB  . GLU B 1 180 ? -23.574 -7.180  6.332   1.00 14.70 ? 180 GLU B CB  1 
ATOM   3602 C  CG  . GLU B 1 180 ? -23.014 -7.902  7.582   1.00 22.63 ? 180 GLU B CG  1 
ATOM   3603 C  CD  . GLU B 1 180 ? -24.079 -8.157  8.649   1.00 25.24 ? 180 GLU B CD  1 
ATOM   3604 O  OE1 . GLU B 1 180 ? -25.248 -7.647  8.482   1.00 24.66 ? 180 GLU B OE1 1 
ATOM   3605 O  OE2 . GLU B 1 180 ? -23.714 -8.866  9.643   1.00 28.69 ? 180 GLU B OE2 1 
ATOM   3606 N  N   . GLU B 1 181 ? -22.200 -7.958  3.298   1.00 9.37  ? 181 GLU B N   1 
ATOM   3607 C  CA  . GLU B 1 181 ? -21.605 -8.963  2.430   1.00 9.62  ? 181 GLU B CA  1 
ATOM   3608 C  C   . GLU B 1 181 ? -20.123 -8.686  2.203   1.00 8.73  ? 181 GLU B C   1 
ATOM   3609 O  O   . GLU B 1 181 ? -19.424 -9.619  1.722   1.00 10.81 ? 181 GLU B O   1 
ATOM   3610 C  CB  . GLU B 1 181 ? -22.257 -8.980  1.060   1.00 11.39 ? 181 GLU B CB  1 
ATOM   3611 C  CG  . GLU B 1 181 ? -23.725 -9.324  1.098   1.00 15.59 ? 181 GLU B CG  1 
ATOM   3612 C  CD  . GLU B 1 181 ? -24.383 -9.113  -0.280  1.00 18.97 ? 181 GLU B CD  1 
ATOM   3613 O  OE1 . GLU B 1 181 ? -23.722 -8.696  -1.285  1.00 22.65 ? 181 GLU B OE1 1 
ATOM   3614 O  OE2 . GLU B 1 181 ? -25.631 -9.342  -0.388  1.00 23.01 ? 181 GLU B OE2 1 
ATOM   3615 N  N   . LEU B 1 182 ? -19.631 -7.489  2.606   1.00 7.29  ? 182 LEU B N   1 
ATOM   3616 C  CA  . LEU B 1 182 ? -18.200 -7.233  2.449   1.00 7.52  ? 182 LEU B CA  1 
ATOM   3617 C  C   . LEU B 1 182 ? -17.452 -7.711  3.664   1.00 7.32  ? 182 LEU B C   1 
ATOM   3618 O  O   . LEU B 1 182 ? -16.202 -7.684  3.644   1.00 7.74  ? 182 LEU B O   1 
ATOM   3619 C  CB  . LEU B 1 182 ? -17.979 -5.693  2.291   1.00 6.75  ? 182 LEU B CB  1 
ATOM   3620 C  CG  . LEU B 1 182 ? -18.700 -5.073  1.049   1.00 6.46  ? 182 LEU B CG  1 
ATOM   3621 C  CD1 . LEU B 1 182 ? -18.328 -3.575  1.005   1.00 6.85  ? 182 LEU B CD1 1 
ATOM   3622 C  CD2 . LEU B 1 182 ? -18.324 -5.711  -0.234  1.00 7.84  ? 182 LEU B CD2 1 
ATOM   3623 N  N   . LEU B 1 183 ? -18.117 -7.997  4.779   1.00 7.85  ? 183 LEU B N   1 
ATOM   3624 C  CA  . LEU B 1 183 ? -17.459 -8.406  6.020   1.00 7.94  ? 183 LEU B CA  1 
ATOM   3625 C  C   . LEU B 1 183 ? -17.179 -9.927  5.968   1.00 8.42  ? 183 LEU B C   1 
ATOM   3626 O  O   . LEU B 1 183 ? -17.834 -10.698 5.269   1.00 9.79  ? 183 LEU B O   1 
ATOM   3627 C  CB  . LEU B 1 183 ? -18.360 -8.090  7.229   1.00 10.34 ? 183 LEU B CB  1 
ATOM   3628 C  CG  . LEU B 1 183 ? -18.787 -6.633  7.308   1.00 11.72 ? 183 LEU B CG  1 
ATOM   3629 C  CD1 . LEU B 1 183 ? -19.662 -6.419  8.533   1.00 16.18 ? 183 LEU B CD1 1 
ATOM   3630 C  CD2 . LEU B 1 183 ? -17.618 -5.712  7.321   1.00 12.59 ? 183 LEU B CD2 1 
ATOM   3631 N  N   . PRO B 1 184 ? -16.139 -10.316 6.700   1.00 8.02  ? 184 PRO B N   1 
ATOM   3632 C  CA  . PRO B 1 184 ? -15.756 -11.761 6.753   1.00 9.97  ? 184 PRO B CA  1 
ATOM   3633 C  C   . PRO B 1 184 ? -16.619 -12.559 7.642   1.00 12.38 ? 184 PRO B C   1 
ATOM   3634 O  O   . PRO B 1 184 ? -17.574 -12.063 8.241   1.00 13.27 ? 184 PRO B O   1 
ATOM   3635 C  CB  . PRO B 1 184 ? -14.378 -11.705 7.387   1.00 11.31 ? 184 PRO B CB  1 
ATOM   3636 C  CG  . PRO B 1 184 ? -14.403 -10.482 8.281   1.00 10.88 ? 184 PRO B CG  1 
ATOM   3637 C  CD  . PRO B 1 184 ? -15.254 -9.511  7.518   1.00 8.94  ? 184 PRO B CD  1 
ATOM   3638 N  N   . GLU B 1 185 ? -16.227 -13.843 7.660   1.00 13.12 ? 185 GLU B N   1 
ATOM   3639 C  CA  . GLU B 1 185 ? -16.797 -14.794 8.622   1.00 15.69 ? 185 GLU B CA  1 
ATOM   3640 C  C   . GLU B 1 185 ? -16.397 -14.411 10.055  1.00 13.76 ? 185 GLU B C   1 
ATOM   3641 O  O   . GLU B 1 185 ? -15.263 -13.922 10.331  1.00 14.33 ? 185 GLU B O   1 
ATOM   3642 C  CB  . GLU B 1 185 ? -16.198 -16.162 8.336   1.00 18.06 ? 185 GLU B CB  1 
ATOM   3643 C  CG  . GLU B 1 185 ? -16.743 -16.661 6.986   1.00 24.53 ? 185 GLU B CG  1 
ATOM   3644 C  CD  . GLU B 1 185 ? -16.640 -18.181 6.807   1.00 35.66 ? 185 GLU B CD  1 
ATOM   3645 O  OE1 . GLU B 1 185 ? -17.661 -18.776 6.367   1.00 48.02 ? 185 GLU B OE1 1 
ATOM   3646 O  OE2 . GLU B 1 185 ? -15.567 -18.776 7.098   1.00 40.66 ? 185 GLU B OE2 1 
ATOM   3647 N  N   . ARG B 1 186 ? -17.301 -14.699 10.969  1.00 14.39 ? 186 ARG B N   1 
ATOM   3648 C  CA  . ARG B 1 186 ? -17.069 -14.615 12.401  1.00 14.56 ? 186 ARG B CA  1 
ATOM   3649 C  C   . ARG B 1 186 ? -16.634 -13.193 12.745  1.00 12.39 ? 186 ARG B C   1 
ATOM   3650 O  O   . ARG B 1 186 ? -15.549 -12.950 13.348  1.00 13.30 ? 186 ARG B O   1 
ATOM   3651 C  CB  . ARG B 1 186 ? -16.064 -15.660 12.890  1.00 17.61 ? 186 ARG B CB  1 
ATOM   3652 C  CG  . ARG B 1 186 ? -16.671 -17.095 12.786  1.00 21.49 ? 186 ARG B CG  1 
ATOM   3653 C  CD  . ARG B 1 186 ? -15.746 -18.258 13.262  1.00 22.39 ? 186 ARG B CD  1 
ATOM   3654 N  NE  . ARG B 1 186 ? -14.455 -18.329 12.546  1.00 25.83 ? 186 ARG B NE  1 
ATOM   3655 C  CZ  . ARG B 1 186 ? -14.325 -18.801 11.312  1.00 30.57 ? 186 ARG B CZ  1 
ATOM   3656 N  NH1 . ARG B 1 186 ? -15.401 -19.220 10.647  1.00 32.42 ? 186 ARG B NH1 1 
ATOM   3657 N  NH2 . ARG B 1 186 ? -13.125 -18.852 10.732  1.00 37.93 ? 186 ARG B NH2 1 
ATOM   3658 N  N   . THR B 1 187 ? -17.503 -12.243 12.405  1.00 11.33 ? 187 THR B N   1 
ATOM   3659 C  CA  . THR B 1 187 ? -17.203 -10.863 12.817  1.00 10.07 ? 187 THR B CA  1 
ATOM   3660 C  C   . THR B 1 187 ? -17.018 -10.645 14.294  1.00 10.74 ? 187 THR B C   1 
ATOM   3661 O  O   . THR B 1 187 ? -16.509 -9.629  14.741  1.00 9.87  ? 187 THR B O   1 
ATOM   3662 C  CB  . THR B 1 187 ? -18.157 -9.885  12.216  1.00 10.89 ? 187 THR B CB  1 
ATOM   3663 O  OG1 . THR B 1 187 ? -19.488 -10.332 12.537  1.00 14.43 ? 187 THR B OG1 1 
ATOM   3664 C  CG2 . THR B 1 187 ? -18.000 -9.742  10.676  1.00 12.70 ? 187 THR B CG2 1 
ATOM   3665 N  N   . ALA B 1 188 ? -17.525 -11.617 15.100  1.00 10.63 ? 188 ALA B N   1 
ATOM   3666 C  CA  . ALA B 1 188 ? -17.249 -11.513 16.494  1.00 10.14 ? 188 ALA B CA  1 
ATOM   3667 C  C   . ALA B 1 188 ? -15.771 -11.579 16.879  1.00 8.72  ? 188 ALA B C   1 
ATOM   3668 O  O   . ALA B 1 188 ? -15.482 -11.102 17.953  1.00 10.53 ? 188 ALA B O   1 
ATOM   3669 C  CB  . ALA B 1 188 ? -17.938 -12.638 17.257  1.00 11.22 ? 188 ALA B CB  1 
ATOM   3670 N  N   . GLU B 1 189 ? -14.904 -12.071 15.995  1.00 9.36  ? 189 GLU B N   1 
ATOM   3671 C  CA  . GLU B 1 189 ? -13.467 -12.181 16.311  1.00 8.73  ? 189 GLU B CA  1 
ATOM   3672 C  C   . GLU B 1 189 ? -12.759 -10.993 15.639  1.00 6.96  ? 189 GLU B C   1 
ATOM   3673 O  O   . GLU B 1 189 ? -12.751 -10.881 14.356  1.00 7.08  ? 189 GLU B O   1 
ATOM   3674 C  CB  . GLU B 1 189 ? -12.924 -13.435 15.727  1.00 10.86 ? 189 GLU B CB  1 
ATOM   3675 C  CG  . GLU B 1 189 ? -13.694 -14.608 16.388  1.00 14.67 ? 189 GLU B CG  1 
ATOM   3676 C  CD  . GLU B 1 189 ? -13.210 -15.968 16.021  1.00 20.41 ? 189 GLU B CD  1 
ATOM   3677 O  OE1 . GLU B 1 189 ? -12.001 -16.213 15.951  1.00 23.18 ? 189 GLU B OE1 1 
ATOM   3678 O  OE2 . GLU B 1 189 ? -14.104 -16.918 15.945  1.00 27.99 ? 189 GLU B OE2 1 
ATOM   3679 N  N   . TYR B 1 190 ? -12.254 -10.103 16.461  1.00 6.07  ? 190 TYR B N   1 
ATOM   3680 C  CA  . TYR B 1 190 ? -11.575 -8.861  15.939  1.00 6.11  ? 190 TYR B CA  1 
ATOM   3681 C  C   . TYR B 1 190 ? -10.464 -8.434  16.869  1.00 6.35  ? 190 TYR B C   1 
ATOM   3682 O  O   . TYR B 1 190 ? -10.416 -8.817  18.057  1.00 6.79  ? 190 TYR B O   1 
ATOM   3683 C  CB  . TYR B 1 190 ? -12.580 -7.720  15.638  1.00 6.50  ? 190 TYR B CB  1 
ATOM   3684 C  CG  . TYR B 1 190 ? -13.410 -7.354  16.887  1.00 6.21  ? 190 TYR B CG  1 
ATOM   3685 C  CD1 . TYR B 1 190 ? -12.912 -6.447  17.869  1.00 6.18  ? 190 TYR B CD1 1 
ATOM   3686 C  CD2 . TYR B 1 190 ? -14.697 -7.894  17.067  1.00 7.79  ? 190 TYR B CD2 1 
ATOM   3687 C  CE1 . TYR B 1 190 ? -13.744 -6.075  18.975  1.00 6.85  ? 190 TYR B CE1 1 
ATOM   3688 C  CE2 . TYR B 1 190 ? -15.459 -7.515  18.200  1.00 7.61  ? 190 TYR B CE2 1 
ATOM   3689 C  CZ  . TYR B 1 190 ? -14.995 -6.600  19.070  1.00 7.82  ? 190 TYR B CZ  1 
ATOM   3690 O  OH  . TYR B 1 190 ? -15.716 -6.219  20.208  1.00 10.04 ? 190 TYR B OH  1 
ATOM   3691 N  N   . TYR B 1 191 ? -9.610  -7.583  16.338  1.00 5.86  ? 191 TYR B N   1 
ATOM   3692 C  CA  . TYR B 1 191 ? -8.599  -6.843  17.037  1.00 5.65  ? 191 TYR B CA  1 
ATOM   3693 C  C   . TYR B 1 191 ? -9.117  -5.442  17.235  1.00 6.51  ? 191 TYR B C   1 
ATOM   3694 O  O   . TYR B 1 191 ? -9.779  -4.851  16.355  1.00 7.20  ? 191 TYR B O   1 
ATOM   3695 C  CB  . TYR B 1 191 ? -7.290  -6.723  16.218  1.00 6.05  ? 191 TYR B CB  1 
ATOM   3696 C  CG  . TYR B 1 191 ? -6.702  -8.030  15.716  1.00 6.37  ? 191 TYR B CG  1 
ATOM   3697 C  CD1 . TYR B 1 191 ? -5.697  -8.666  16.420  1.00 6.94  ? 191 TYR B CD1 1 
ATOM   3698 C  CD2 . TYR B 1 191 ? -7.066  -8.497  14.466  1.00 6.90  ? 191 TYR B CD2 1 
ATOM   3699 C  CE1 . TYR B 1 191 ? -5.110  -9.817  15.918  1.00 8.86  ? 191 TYR B CE1 1 
ATOM   3700 C  CE2 . TYR B 1 191 ? -6.462  -9.603  13.911  1.00 8.32  ? 191 TYR B CE2 1 
ATOM   3701 C  CZ  . TYR B 1 191 ? -5.506  -10.275 14.680  1.00 8.60  ? 191 TYR B CZ  1 
ATOM   3702 O  OH  . TYR B 1 191 ? -4.902  -11.386 14.130  1.00 12.39 ? 191 TYR B OH  1 
ATOM   3703 N  N   . ARG B 1 192 ? -8.853  -4.860  18.378  1.00 5.90  ? 192 ARG B N   1 
ATOM   3704 C  CA  . ARG B 1 192 ? -9.291  -3.483  18.695  1.00 6.69  ? 192 ARG B CA  1 
ATOM   3705 C  C   . ARG B 1 192 ? -8.209  -2.678  19.239  1.00 6.48  ? 192 ARG B C   1 
ATOM   3706 O  O   . ARG B 1 192 ? -7.520  -3.088  20.176  1.00 6.97  ? 192 ARG B O   1 
ATOM   3707 C  CB  . ARG B 1 192 ? -10.410 -3.592  19.750  1.00 6.95  ? 192 ARG B CB  1 
ATOM   3708 C  CG  . ARG B 1 192 ? -10.746 -2.270  20.433  1.00 10.59 ? 192 ARG B CG  1 
ATOM   3709 C  CD  . ARG B 1 192 ? -11.514 -1.302  19.543  1.00 11.49 ? 192 ARG B CD  1 
ATOM   3710 N  NE  . ARG B 1 192 ? -12.628 -1.849  18.786  1.00 12.51 ? 192 ARG B NE  1 
ATOM   3711 C  CZ  . ARG B 1 192 ? -13.815 -2.176  19.261  1.00 11.00 ? 192 ARG B CZ  1 
ATOM   3712 N  NH1 . ARG B 1 192 ? -14.092 -2.072  20.590  1.00 13.20 ? 192 ARG B NH1 1 
ATOM   3713 N  NH2 . ARG B 1 192 ? -14.731 -2.630  18.503  1.00 11.97 ? 192 ARG B NH2 1 
ATOM   3714 N  N   . TYR B 1 193 ? -7.971  -1.458  18.723  1.00 6.13  ? 193 TYR B N   1 
ATOM   3715 C  CA  . TYR B 1 193 ? -6.913  -0.602  19.290  1.00 6.87  ? 193 TYR B CA  1 
ATOM   3716 C  C   . TYR B 1 193 ? -7.201  0.838   18.954  1.00 8.17  ? 193 TYR B C   1 
ATOM   3717 O  O   . TYR B 1 193 ? -7.955  1.166   18.037  1.00 7.77  ? 193 TYR B O   1 
ATOM   3718 C  CB  . TYR B 1 193 ? -5.504  -1.049  18.849  1.00 6.89  ? 193 TYR B CB  1 
ATOM   3719 C  CG  . TYR B 1 193 ? -5.128  -0.653  17.431  1.00 6.40  ? 193 TYR B CG  1 
ATOM   3720 C  CD1 . TYR B 1 193 ? -4.366  0.503   17.204  1.00 6.40  ? 193 TYR B CD1 1 
ATOM   3721 C  CD2 . TYR B 1 193 ? -5.499  -1.434  16.329  1.00 5.99  ? 193 TYR B CD2 1 
ATOM   3722 C  CE1 . TYR B 1 193 ? -4.003  0.883   15.944  1.00 6.76  ? 193 TYR B CE1 1 
ATOM   3723 C  CE2 . TYR B 1 193 ? -5.215  -1.023  15.017  1.00 5.92  ? 193 TYR B CE2 1 
ATOM   3724 C  CZ  . TYR B 1 193 ? -4.432  0.154   14.867  1.00 6.42  ? 193 TYR B CZ  1 
ATOM   3725 O  OH  . TYR B 1 193 ? -4.077  0.570   13.613  1.00 6.96  ? 193 TYR B OH  1 
ATOM   3726 N  N   . ARG B 1 194 ? -6.612  1.717   19.749  1.00 9.88  ? 194 ARG B N   1 
ATOM   3727 C  CA  . ARG B 1 194 ? -6.718  3.186   19.491  1.00 10.06 ? 194 ARG B CA  1 
ATOM   3728 C  C   . ARG B 1 194 ? -5.606  3.569   18.620  1.00 9.01  ? 194 ARG B C   1 
ATOM   3729 O  O   . ARG B 1 194 ? -4.470  3.373   18.833  1.00 9.65  ? 194 ARG B O   1 
ATOM   3730 C  CB  . ARG B 1 194 ? -6.697  3.943   20.835  1.00 14.80 ? 194 ARG B CB  1 
ATOM   3731 C  CG  . ARG B 1 194 ? -8.084  3.810   21.526  1.00 19.07 ? 194 ARG B CG  1 
ATOM   3732 C  CD  . ARG B 1 194 ? -8.135  4.480   22.925  1.00 31.77 ? 194 ARG B CD  1 
ATOM   3733 N  NE  . ARG B 1 194 ? -9.195  3.908   23.780  1.00 45.45 ? 194 ARG B NE  1 
ATOM   3734 C  CZ  . ARG B 1 194 ? -10.510 4.019   23.545  1.00 52.04 ? 194 ARG B CZ  1 
ATOM   3735 N  NH1 . ARG B 1 194 ? -10.952 4.697   22.484  1.00 51.78 ? 194 ARG B NH1 1 
ATOM   3736 N  NH2 . ARG B 1 194 ? -11.389 3.440   24.357  1.00 52.67 ? 194 ARG B NH2 1 
ATOM   3737 N  N   . GLY B 1 195 ? -5.961  4.213   17.480  1.00 8.09  ? 195 GLY B N   1 
ATOM   3738 C  CA  . GLY B 1 195 ? -4.988  4.641   16.518  1.00 9.10  ? 195 GLY B CA  1 
ATOM   3739 C  C   . GLY B 1 195 ? -5.383  5.908   15.784  1.00 9.05  ? 195 GLY B C   1 
ATOM   3740 O  O   . GLY B 1 195 ? -5.992  6.812   16.319  1.00 9.28  ? 195 GLY B O   1 
ATOM   3741 N  N   . SER B 1 196 ? -5.029  5.954   14.519  1.00 7.81  ? 196 SER B N   1 
ATOM   3742 C  CA  . SER B 1 196 ? -5.086  7.206   13.784  1.00 6.50  ? 196 SER B CA  1 
ATOM   3743 C  C   . SER B 1 196 ? -5.634  6.946   12.413  1.00 6.20  ? 196 SER B C   1 
ATOM   3744 O  O   . SER B 1 196 ? -5.728  5.802   11.878  1.00 6.24  ? 196 SER B O   1 
ATOM   3745 C  CB  . SER B 1 196 ? -3.667  7.871   13.634  1.00 7.22  ? 196 SER B CB  1 
ATOM   3746 O  OG  . SER B 1 196 ? -2.887  7.172   12.661  1.00 6.47  ? 196 SER B OG  1 
ATOM   3747 N  N   . LEU B 1 197 ? -5.925  8.043   11.727  1.00 5.45  ? 197 LEU B N   1 
ATOM   3748 C  CA  . LEU B 1 197 ? -6.065  7.983   10.253  1.00 5.87  ? 197 LEU B CA  1 
ATOM   3749 C  C   . LEU B 1 197 ? -4.745  7.528   9.664   1.00 5.85  ? 197 LEU B C   1 
ATOM   3750 O  O   . LEU B 1 197 ? -3.641  7.877   10.140  1.00 7.04  ? 197 LEU B O   1 
ATOM   3751 C  CB  . LEU B 1 197 ? -6.384  9.402   9.661   1.00 6.71  ? 197 LEU B CB  1 
ATOM   3752 C  CG  . LEU B 1 197 ? -7.642  10.027  10.176  1.00 8.95  ? 197 LEU B CG  1 
ATOM   3753 C  CD1 . LEU B 1 197 ? -7.693  11.411  9.490   1.00 10.23 ? 197 LEU B CD1 1 
ATOM   3754 C  CD2 . LEU B 1 197 ? -8.899  9.265   9.863   1.00 11.83 ? 197 LEU B CD2 1 
ATOM   3755 N  N   . THR B 1 198 ? -4.866  6.714   8.571   1.00 5.71  ? 198 THR B N   1 
ATOM   3756 C  CA  . THR B 1 198 ? -3.610  6.290   7.934   1.00 5.82  ? 198 THR B CA  1 
ATOM   3757 C  C   . THR B 1 198 ? -3.112  7.130   6.775   1.00 6.08  ? 198 THR B C   1 
ATOM   3758 O  O   . THR B 1 198 ? -2.131  6.786   6.081   1.00 6.10  ? 198 THR B O   1 
ATOM   3759 C  CB  . THR B 1 198 ? -3.721  4.848   7.415   1.00 5.11  ? 198 THR B CB  1 
ATOM   3760 O  OG1 . THR B 1 198 ? -4.720  4.818   6.377   1.00 5.42  ? 198 THR B OG1 1 
ATOM   3761 C  CG2 . THR B 1 198 ? -4.092  3.885   8.536   1.00 5.56  ? 198 THR B CG2 1 
ATOM   3762 N  N   . THR B 1 199 ? -3.871  8.247   6.538   1.00 6.47  ? 199 THR B N   1 
ATOM   3763 C  CA  . THR B 1 199 ? -3.455  9.264   5.532   1.00 7.16  ? 199 THR B CA  1 
ATOM   3764 C  C   . THR B 1 199 ? -3.387  10.540  6.290   1.00 7.12  ? 199 THR B C   1 
ATOM   3765 O  O   . THR B 1 199 ? -4.069  10.709  7.294   1.00 7.07  ? 199 THR B O   1 
ATOM   3766 C  CB  . THR B 1 199 ? -4.525  9.443   4.377   1.00 7.59  ? 199 THR B CB  1 
ATOM   3767 O  OG1 . THR B 1 199 ? -5.804  9.752   4.964   1.00 11.51 ? 199 THR B OG1 1 
ATOM   3768 C  CG2 . THR B 1 199 ? -4.724  8.081   3.710   1.00 8.36  ? 199 THR B CG2 1 
ATOM   3769 N  N   . PRO B 1 200 ? -2.683  11.502  5.691   1.00 6.77  ? 200 PRO B N   1 
ATOM   3770 C  CA  . PRO B 1 200 ? -2.840  12.873  6.188   1.00 7.65  ? 200 PRO B CA  1 
ATOM   3771 C  C   . PRO B 1 200 ? -4.307  13.259  6.322   1.00 7.74  ? 200 PRO B C   1 
ATOM   3772 O  O   . PRO B 1 200 ? -5.086  12.946  5.435   1.00 9.20  ? 200 PRO B O   1 
ATOM   3773 C  CB  . PRO B 1 200 ? -2.127  13.713  5.081   1.00 8.02  ? 200 PRO B CB  1 
ATOM   3774 C  CG  . PRO B 1 200 ? -1.004  12.818  4.618   1.00 8.50  ? 200 PRO B CG  1 
ATOM   3775 C  CD  . PRO B 1 200 ? -1.776  11.452  4.525   1.00 7.45  ? 200 PRO B CD  1 
ATOM   3776 N  N   . PRO B 1 201 ? -4.672  13.972  7.399   1.00 8.38  ? 201 PRO B N   1 
ATOM   3777 C  CA  . PRO B 1 201 ? -3.793  14.610  8.366   1.00 7.97  ? 201 PRO B CA  1 
ATOM   3778 C  C   . PRO B 1 201 ? -3.348  13.723  9.525   1.00 8.68  ? 201 PRO B C   1 
ATOM   3779 O  O   . PRO B 1 201 ? -2.729  14.198  10.511  1.00 8.88  ? 201 PRO B O   1 
ATOM   3780 C  CB  . PRO B 1 201 ? -4.657  15.768  8.952   1.00 9.37  ? 201 PRO B CB  1 
ATOM   3781 C  CG  . PRO B 1 201 ? -6.062  15.238  8.756   1.00 12.21 ? 201 PRO B CG  1 
ATOM   3782 C  CD  . PRO B 1 201 ? -6.076  14.375  7.534   1.00 8.57  ? 201 PRO B CD  1 
ATOM   3783 N  N   . CYS B 1 202 ? -3.647  12.408  9.466   1.00 7.25  ? 202 CYS B N   1 
ATOM   3784 C  CA  . CYS B 1 202 ? -3.099  11.381  10.448  1.00 7.31  ? 202 CYS B CA  1 
ATOM   3785 C  C   . CYS B 1 202 ? -3.632  11.651  11.878  1.00 7.36  ? 202 CYS B C   1 
ATOM   3786 O  O   . CYS B 1 202 ? -2.992  11.222  12.848  1.00 7.79  ? 202 CYS B O   1 
ATOM   3787 C  CB  . CYS B 1 202 ? -1.538  11.366  10.467  1.00 7.98  ? 202 CYS B CB  1 
ATOM   3788 S  SG  . CYS B 1 202 ? -0.808  10.994  8.896   1.00 8.30  ? 202 CYS B SG  1 
ATOM   3789 N  N   . ASN B 1 203 ? -4.812  12.240  11.962  1.00 8.89  ? 203 ASN B N   1 
ATOM   3790 C  CA  . ASN B 1 203 ? -5.376  12.579  13.278  1.00 9.87  ? 203 ASN B CA  1 
ATOM   3791 C  C   . ASN B 1 203 ? -5.382  11.309  14.129  1.00 9.78  ? 203 ASN B C   1 
ATOM   3792 O  O   . ASN B 1 203 ? -5.936  10.294  13.721  1.00 8.27  ? 203 ASN B O   1 
ATOM   3793 C  CB  . ASN B 1 203 ? -6.772  13.093  13.143  1.00 12.58 ? 203 ASN B CB  1 
ATOM   3794 C  CG  . ASN B 1 203 ? -6.860  14.406  12.358  1.00 17.20 ? 203 ASN B CG  1 
ATOM   3795 O  OD1 . ASN B 1 203 ? -5.860  15.131  12.219  1.00 21.29 ? 203 ASN B OD1 1 
ATOM   3796 N  ND2 . ASN B 1 203 ? -8.105  14.790  12.016  1.00 19.09 ? 203 ASN B ND2 1 
ATOM   3797 N  N   . PRO B 1 204 ? -4.960  11.360  15.411  1.00 9.20  ? 204 PRO B N   1 
ATOM   3798 C  CA  . PRO B 1 204 ? -5.070  10.212  16.344  1.00 10.25 ? 204 PRO B CA  1 
ATOM   3799 C  C   . PRO B 1 204 ? -6.425  10.014  16.964  1.00 11.64 ? 204 PRO B C   1 
ATOM   3800 O  O   . PRO B 1 204 ? -6.580  10.002  18.231  1.00 13.91 ? 204 PRO B O   1 
ATOM   3801 C  CB  . PRO B 1 204 ? -3.962  10.471  17.374  1.00 10.27 ? 204 PRO B CB  1 
ATOM   3802 C  CG  . PRO B 1 204 ? -3.979  11.983  17.487  1.00 10.21 ? 204 PRO B CG  1 
ATOM   3803 C  CD  . PRO B 1 204 ? -4.242  12.485  16.041  1.00 10.95 ? 204 PRO B CD  1 
ATOM   3804 N  N   . THR B 1 205 ? -7.445  9.800   16.173  1.00 9.83  ? 205 THR B N   1 
ATOM   3805 C  CA  . THR B 1 205 ? -8.805  9.901   16.630  1.00 11.23 ? 205 THR B CA  1 
ATOM   3806 C  C   . THR B 1 205 ? -9.630  8.738   16.210  1.00 10.03 ? 205 THR B C   1 
ATOM   3807 O  O   . THR B 1 205 ? -10.822 8.822   16.213  1.00 12.64 ? 205 THR B O   1 
ATOM   3808 C  CB  . THR B 1 205 ? -9.467  11.145  15.988  1.00 13.15 ? 205 THR B CB  1 
ATOM   3809 O  OG1 . THR B 1 205 ? -9.272  11.135  14.589  1.00 13.18 ? 205 THR B OG1 1 
ATOM   3810 C  CG2 . THR B 1 205 ? -8.779  12.385  16.565  1.00 14.95 ? 205 THR B CG2 1 
ATOM   3811 N  N   . VAL B 1 206 ? -8.972  7.594   15.886  1.00 7.89  ? 206 VAL B N   1 
ATOM   3812 C  CA  . VAL B 1 206 ? -9.747  6.443   15.389  1.00 8.24  ? 206 VAL B CA  1 
ATOM   3813 C  C   . VAL B 1 206 ? -9.708  5.276   16.330  1.00 7.95  ? 206 VAL B C   1 
ATOM   3814 O  O   . VAL B 1 206 ? -8.634  4.890   16.791  1.00 9.61  ? 206 VAL B O   1 
ATOM   3815 C  CB  . VAL B 1 206 ? -9.149  5.955   14.015  1.00 8.32  ? 206 VAL B CB  1 
ATOM   3816 C  CG1 . VAL B 1 206 ? -9.783  4.677   13.544  1.00 8.64  ? 206 VAL B CG1 1 
ATOM   3817 C  CG2 . VAL B 1 206 ? -9.146  7.053   12.949  1.00 9.15  ? 206 VAL B CG2 1 
ATOM   3818 N  N   . LEU B 1 207 ? -10.859 4.754   16.609  1.00 7.30  ? 207 LEU B N   1 
ATOM   3819 C  CA  . LEU B 1 207 ? -11.011 3.477   17.247  1.00 8.30  ? 207 LEU B CA  1 
ATOM   3820 C  C   . LEU B 1 207 ? -11.038 2.415   16.132  1.00 6.35  ? 207 LEU B C   1 
ATOM   3821 O  O   . LEU B 1 207 ? -11.995 2.328   15.398  1.00 7.38  ? 207 LEU B O   1 
ATOM   3822 C  CB  . LEU B 1 207 ? -12.327 3.430   18.035  1.00 10.52 ? 207 LEU B CB  1 
ATOM   3823 C  CG  . LEU B 1 207 ? -12.438 2.210   18.926  1.00 15.18 ? 207 LEU B CG  1 
ATOM   3824 C  CD1 . LEU B 1 207 ? -11.279 2.138   19.909  1.00 17.52 ? 207 LEU B CD1 1 
ATOM   3825 C  CD2 . LEU B 1 207 ? -13.743 2.244   19.667  1.00 19.07 ? 207 LEU B CD2 1 
ATOM   3826 N  N   . TRP B 1 208 ? -9.973  1.599   16.058  1.00 6.15  ? 208 TRP B N   1 
ATOM   3827 C  CA  . TRP B 1 208 ? -9.831  0.616   14.982  1.00 5.93  ? 208 TRP B CA  1 
ATOM   3828 C  C   . TRP B 1 208 ? -10.434 -0.707  15.403  1.00 6.04  ? 208 TRP B C   1 
ATOM   3829 O  O   . TRP B 1 208 ? -10.195 -1.166  16.569  1.00 7.20  ? 208 TRP B O   1 
ATOM   3830 C  CB  . TRP B 1 208 ? -8.347  0.371   14.651  1.00 6.02  ? 208 TRP B CB  1 
ATOM   3831 C  CG  . TRP B 1 208 ? -7.798  1.450   13.748  1.00 5.64  ? 208 TRP B CG  1 
ATOM   3832 C  CD1 . TRP B 1 208 ? -7.092  2.597   14.085  1.00 5.51  ? 208 TRP B CD1 1 
ATOM   3833 C  CD2 . TRP B 1 208 ? -7.964  1.502   12.332  1.00 5.29  ? 208 TRP B CD2 1 
ATOM   3834 N  NE1 . TRP B 1 208 ? -6.842  3.376   12.999  1.00 5.94  ? 208 TRP B NE1 1 
ATOM   3835 C  CE2 . TRP B 1 208 ? -7.386  2.735   11.903  1.00 4.56  ? 208 TRP B CE2 1 
ATOM   3836 C  CE3 . TRP B 1 208 ? -8.586  0.645   11.377  1.00 5.09  ? 208 TRP B CE3 1 
ATOM   3837 C  CZ2 . TRP B 1 208 ? -7.405  3.146   10.544  1.00 4.62  ? 208 TRP B CZ2 1 
ATOM   3838 C  CZ3 . TRP B 1 208 ? -8.591  1.014   10.048  1.00 5.16  ? 208 TRP B CZ3 1 
ATOM   3839 C  CH2 . TRP B 1 208 ? -7.965  2.254   9.626   1.00 4.59  ? 208 TRP B CH2 1 
ATOM   3840 N  N   . THR B 1 209 ? -11.180 -1.347  14.516  1.00 5.01  ? 209 THR B N   1 
ATOM   3841 C  CA  . THR B 1 209 ? -11.587 -2.767  14.640  1.00 5.33  ? 209 THR B CA  1 
ATOM   3842 C  C   . THR B 1 209 ? -11.113 -3.443  13.436  1.00 5.66  ? 209 THR B C   1 
ATOM   3843 O  O   . THR B 1 209 ? -11.567 -3.159  12.322  1.00 6.22  ? 209 THR B O   1 
ATOM   3844 C  CB  . THR B 1 209 ? -13.087 -2.839  14.767  1.00 5.54  ? 209 THR B CB  1 
ATOM   3845 O  OG1 . THR B 1 209 ? -13.508 -2.118  15.924  1.00 7.20  ? 209 THR B OG1 1 
ATOM   3846 C  CG2 . THR B 1 209 ? -13.617 -4.316  14.891  1.00 6.30  ? 209 THR B CG2 1 
ATOM   3847 N  N   . VAL B 1 210 ? -10.193 -4.390  13.581  1.00 5.27  ? 210 VAL B N   1 
ATOM   3848 C  CA  . VAL B 1 210 ? -9.723  -5.167  12.401  1.00 5.41  ? 210 VAL B CA  1 
ATOM   3849 C  C   . VAL B 1 210 ? -10.237 -6.566  12.534  1.00 5.45  ? 210 VAL B C   1 
ATOM   3850 O  O   . VAL B 1 210 ? -9.947  -7.243  13.536  1.00 6.02  ? 210 VAL B O   1 
ATOM   3851 C  CB  . VAL B 1 210 ? -8.138  -5.191  12.385  1.00 5.37  ? 210 VAL B CB  1 
ATOM   3852 C  CG1 . VAL B 1 210 ? -7.649  -5.967  11.175  1.00 5.78  ? 210 VAL B CG1 1 
ATOM   3853 C  CG2 . VAL B 1 210 ? -7.569  -3.753  12.339  1.00 6.78  ? 210 VAL B CG2 1 
ATOM   3854 N  N   . PHE B 1 211 ? -11.056 -7.015  11.653  1.00 5.07  ? 211 PHE B N   1 
ATOM   3855 C  CA  . PHE B 1 211 ? -11.565 -8.412  11.787  1.00 5.58  ? 211 PHE B CA  1 
ATOM   3856 C  C   . PHE B 1 211 ? -10.448 -9.431  11.685  1.00 6.05  ? 211 PHE B C   1 
ATOM   3857 O  O   . PHE B 1 211 ? -9.490  -9.280  10.902  1.00 5.78  ? 211 PHE B O   1 
ATOM   3858 C  CB  . PHE B 1 211 ? -12.677 -8.622  10.773  1.00 6.35  ? 211 PHE B CB  1 
ATOM   3859 C  CG  . PHE B 1 211 ? -13.889 -7.743  11.043  1.00 7.14  ? 211 PHE B CG  1 
ATOM   3860 C  CD1 . PHE B 1 211 ? -14.188 -6.649  10.243  1.00 8.78  ? 211 PHE B CD1 1 
ATOM   3861 C  CD2 . PHE B 1 211 ? -14.672 -8.028  12.213  1.00 6.89  ? 211 PHE B CD2 1 
ATOM   3862 C  CE1 . PHE B 1 211 ? -15.293 -5.837  10.565  1.00 8.94  ? 211 PHE B CE1 1 
ATOM   3863 C  CE2 . PHE B 1 211 ? -15.740 -7.211  12.531  1.00 8.96  ? 211 PHE B CE2 1 
ATOM   3864 C  CZ  . PHE B 1 211 ? -16.091 -6.143  11.706  1.00 9.55  ? 211 PHE B CZ  1 
ATOM   3865 N  N   . ARG B 1 212 ? -10.581 -10.494 12.497  1.00 6.48  ? 212 ARG B N   1 
ATOM   3866 C  CA  . ARG B 1 212 ? -9.560  -11.529 12.470  1.00 6.69  ? 212 ARG B CA  1 
ATOM   3867 C  C   . ARG B 1 212 ? -9.464  -12.264 11.124  1.00 7.15  ? 212 ARG B C   1 
ATOM   3868 O  O   . ARG B 1 212 ? -8.338  -12.606 10.754  1.00 8.52  ? 212 ARG B O   1 
ATOM   3869 C  CB  . ARG B 1 212 ? -9.903  -12.516 13.563  1.00 6.61  ? 212 ARG B CB  1 
ATOM   3870 C  CG  . ARG B 1 212 ? -8.812  -13.566 13.796  1.00 8.16  ? 212 ARG B CG  1 
ATOM   3871 C  CD  . ARG B 1 212 ? -9.331  -14.716 14.690  1.00 10.13 ? 212 ARG B CD  1 
ATOM   3872 N  NE  . ARG B 1 212 ? -8.196  -15.553 15.077  1.00 13.44 ? 212 ARG B NE  1 
ATOM   3873 C  CZ  . ARG B 1 212 ? -8.245  -16.551 15.952  1.00 15.84 ? 212 ARG B CZ  1 
ATOM   3874 N  NH1 . ARG B 1 212 ? -9.386  -16.860 16.551  1.00 16.56 ? 212 ARG B NH1 1 
ATOM   3875 N  NH2 . ARG B 1 212 ? -7.146  -17.241 16.227  1.00 16.92 ? 212 ARG B NH2 1 
ATOM   3876 N  N   . ASN B 1 213 ? -10.606 -12.491 10.479  1.00 6.98  ? 213 ASN B N   1 
ATOM   3877 C  CA  . ASN B 1 213 ? -10.574 -13.394 9.330   1.00 8.32  ? 213 ASN B CA  1 
ATOM   3878 C  C   . ASN B 1 213 ? -10.615 -12.514 8.075   1.00 8.08  ? 213 ASN B C   1 
ATOM   3879 O  O   . ASN B 1 213 ? -11.424 -11.545 8.007   1.00 7.70  ? 213 ASN B O   1 
ATOM   3880 C  CB  . ASN B 1 213 ? -11.846 -14.242 9.409   1.00 10.75 ? 213 ASN B CB  1 
ATOM   3881 C  CG  . ASN B 1 213 ? -11.841 -15.125 10.667  1.00 13.61 ? 213 ASN B CG  1 
ATOM   3882 O  OD1 . ASN B 1 213 ? -12.798 -15.165 11.371  1.00 19.95 ? 213 ASN B OD1 1 
ATOM   3883 N  ND2 . ASN B 1 213 ? -10.768 -15.778 10.901  1.00 18.13 ? 213 ASN B ND2 1 
ATOM   3884 N  N   . PRO B 1 214 ? -9.848  -12.800 7.065   1.00 7.88  ? 214 PRO B N   1 
ATOM   3885 C  CA  . PRO B 1 214 ? -9.908  -12.112 5.768   1.00 7.28  ? 214 PRO B CA  1 
ATOM   3886 C  C   . PRO B 1 214 ? -11.051 -12.511 4.937   1.00 6.83  ? 214 PRO B C   1 
ATOM   3887 O  O   . PRO B 1 214 ? -11.633 -13.632 5.131   1.00 8.72  ? 214 PRO B O   1 
ATOM   3888 C  CB  . PRO B 1 214 ? -8.566  -12.450 5.135   1.00 8.44  ? 214 PRO B CB  1 
ATOM   3889 C  CG  . PRO B 1 214 ? -8.338  -13.861 5.593   1.00 10.69 ? 214 PRO B CG  1 
ATOM   3890 C  CD  . PRO B 1 214 ? -8.761  -13.836 7.087   1.00 9.90  ? 214 PRO B CD  1 
ATOM   3891 N  N   . VAL B 1 215 ? -11.371 -11.692 3.943   1.00 6.04  ? 215 VAL B N   1 
ATOM   3892 C  CA  . VAL B 1 215 ? -12.190 -12.093 2.841   1.00 6.00  ? 215 VAL B CA  1 
ATOM   3893 C  C   . VAL B 1 215 ? -11.331 -12.352 1.631   1.00 5.94  ? 215 VAL B C   1 
ATOM   3894 O  O   . VAL B 1 215 ? -10.135 -12.080 1.619   1.00 6.90  ? 215 VAL B O   1 
ATOM   3895 C  CB  . VAL B 1 215 ? -13.261 -11.039 2.490   1.00 6.84  ? 215 VAL B CB  1 
ATOM   3896 C  CG1 . VAL B 1 215 ? -14.220 -10.825 3.678   1.00 6.87  ? 215 VAL B CG1 1 
ATOM   3897 C  CG2 . VAL B 1 215 ? -12.629 -9.738  1.952   1.00 7.05  ? 215 VAL B CG2 1 
ATOM   3898 N  N   . GLN B 1 216 ? -11.868 -12.978 0.578   1.00 6.07  ? 216 GLN B N   1 
ATOM   3899 C  CA  . GLN B 1 216 ? -11.156 -13.211 -0.672  1.00 5.46  ? 216 GLN B CA  1 
ATOM   3900 C  C   . GLN B 1 216 ? -11.776 -12.470 -1.832  1.00 5.29  ? 216 GLN B C   1 
ATOM   3901 O  O   . GLN B 1 216 ? -13.000 -12.330 -1.939  1.00 7.07  ? 216 GLN B O   1 
ATOM   3902 C  CB  . GLN B 1 216 ? -11.205 -14.739 -1.105  1.00 7.62  ? 216 GLN B CB  1 
ATOM   3903 C  CG  . GLN B 1 216 ? -10.509 -15.612 -0.052  1.00 8.12  ? 216 GLN B CG  1 
ATOM   3904 C  CD  . GLN B 1 216 ? -10.459 -17.095 -0.499  1.00 11.90 ? 216 GLN B CD  1 
ATOM   3905 O  OE1 . GLN B 1 216 ? -11.043 -17.551 -1.517  1.00 10.66 ? 216 GLN B OE1 1 
ATOM   3906 N  NE2 . GLN B 1 216 ? -9.635  -17.863 0.270   1.00 21.27 ? 216 GLN B NE2 1 
ATOM   3907 N  N   . ILE B 1 217 ? -10.928 -11.981 -2.694  1.00 5.00  ? 217 ILE B N   1 
ATOM   3908 C  CA  . ILE B 1 217 ? -11.344 -11.494 -4.023  1.00 5.20  ? 217 ILE B CA  1 
ATOM   3909 C  C   . ILE B 1 217 ? -10.386 -12.185 -5.033  1.00 5.04  ? 217 ILE B C   1 
ATOM   3910 O  O   . ILE B 1 217 ? -9.284  -12.595 -4.645  1.00 5.41  ? 217 ILE B O   1 
ATOM   3911 C  CB  . ILE B 1 217 ? -11.345 -9.909  -4.153  1.00 5.55  ? 217 ILE B CB  1 
ATOM   3912 C  CG1 . ILE B 1 217 ? -9.946  -9.411  -4.125  1.00 5.92  ? 217 ILE B CG1 1 
ATOM   3913 C  CG2 . ILE B 1 217 ? -12.264 -9.310  -3.059  1.00 5.79  ? 217 ILE B CG2 1 
ATOM   3914 C  CD1 . ILE B 1 217 ? -9.822  -7.880  -4.238  1.00 7.76  ? 217 ILE B CD1 1 
ATOM   3915 N  N   . SER B 1 218 ? -10.780 -12.201 -6.301  1.00 4.98  ? 218 SER B N   1 
ATOM   3916 C  CA  . SER B 1 218 ? -9.897  -12.933 -7.216  1.00 5.86  ? 218 SER B CA  1 
ATOM   3917 C  C   . SER B 1 218 ? -8.726  -12.189 -7.713  1.00 6.73  ? 218 SER B C   1 
ATOM   3918 O  O   . SER B 1 218 ? -8.660  -10.920 -7.630  1.00 5.84  ? 218 SER B O   1 
ATOM   3919 C  CB  . SER B 1 218 ? -10.683 -13.466 -8.413  1.00 6.77  ? 218 SER B CB  1 
ATOM   3920 O  OG  . SER B 1 218 ? -11.148 -12.389 -9.247  1.00 7.85  ? 218 SER B OG  1 
ATOM   3921 N  N   . GLN B 1 219 ? -7.771  -12.883 -8.306  1.00 7.93  ? 219 GLN B N   1 
ATOM   3922 C  CA  . GLN B 1 219 ? -6.671  -12.218 -9.043  1.00 8.80  ? 219 GLN B CA  1 
ATOM   3923 C  C   . GLN B 1 219 ? -7.210  -11.206 -10.080 1.00 8.29  ? 219 GLN B C   1 
ATOM   3924 O  O   . GLN B 1 219 ? -6.594  -10.105 -10.154 1.00 8.72  ? 219 GLN B O   1 
ATOM   3925 C  CB  . GLN B 1 219 ? -5.829  -13.278 -9.740  1.00 11.88 ? 219 GLN B CB  1 
ATOM   3926 C  CG  . GLN B 1 219 ? -4.504  -12.828 -10.371 1.00 16.79 ? 219 GLN B CG  1 
ATOM   3927 C  CD  . GLN B 1 219 ? -4.423  -11.894 -11.584 1.00 26.33 ? 219 GLN B CD  1 
ATOM   3928 O  OE1 . GLN B 1 219 ? -3.520  -11.024 -11.615 1.00 25.62 ? 219 GLN B OE1 1 
ATOM   3929 N  NE2 . GLN B 1 219 ? -5.254  -12.131 -12.626 1.00 29.79 ? 219 GLN B NE2 1 
ATOM   3930 N  N   . GLU B 1 220 ? -8.220  -11.575 -10.851 1.00 8.99  ? 220 GLU B N   1 
ATOM   3931 C  CA  . GLU B 1 220 ? -8.705  -10.660 -11.867 1.00 9.73  ? 220 GLU B CA  1 
ATOM   3932 C  C   . GLU B 1 220 ? -9.316  -9.425  -11.197 1.00 9.23  ? 220 GLU B C   1 
ATOM   3933 O  O   . GLU B 1 220 ? -9.180  -8.273  -11.713 1.00 9.84  ? 220 GLU B O   1 
ATOM   3934 C  CB  . GLU B 1 220 ? -9.698  -11.315 -12.797 1.00 11.93 ? 220 GLU B CB  1 
ATOM   3935 C  CG  . GLU B 1 220 ? -8.983  -12.459 -13.586 1.00 14.85 ? 220 GLU B CG  1 
ATOM   3936 C  CD  . GLU B 1 220 ? -8.820  -13.795 -12.867 1.00 17.74 ? 220 GLU B CD  1 
ATOM   3937 O  OE1 . GLU B 1 220 ? -9.201  -14.029 -11.708 1.00 15.75 ? 220 GLU B OE1 1 
ATOM   3938 O  OE2 . GLU B 1 220 ? -8.175  -14.680 -13.493 1.00 26.15 ? 220 GLU B OE2 1 
ATOM   3939 N  N   . GLN B 1 221 ? -9.944  -9.601  -10.047 1.00 7.15  ? 221 GLN B N   1 
ATOM   3940 C  CA  . GLN B 1 221 ? -10.489 -8.403  -9.347  1.00 6.69  ? 221 GLN B CA  1 
ATOM   3941 C  C   . GLN B 1 221 ? -9.407  -7.554  -8.835  1.00 6.93  ? 221 GLN B C   1 
ATOM   3942 O  O   . GLN B 1 221 ? -9.469  -6.306  -8.950  1.00 6.79  ? 221 GLN B O   1 
ATOM   3943 C  CB  . GLN B 1 221 ? -11.401 -8.857  -8.241  1.00 6.24  ? 221 GLN B CB  1 
ATOM   3944 C  CG  . GLN B 1 221 ? -12.719 -9.404  -8.702  1.00 6.19  ? 221 GLN B CG  1 
ATOM   3945 C  CD  . GLN B 1 221 ? -13.608 -9.850  -7.564  1.00 5.79  ? 221 GLN B CD  1 
ATOM   3946 O  OE1 . GLN B 1 221 ? -13.287 -10.816 -6.802  1.00 6.67  ? 221 GLN B OE1 1 
ATOM   3947 N  NE2 . GLN B 1 221 ? -14.775 -9.209  -7.374  1.00 6.48  ? 221 GLN B NE2 1 
ATOM   3948 N  N   . LEU B 1 222 ? -8.353  -8.148  -8.289  1.00 7.07  ? 222 LEU B N   1 
ATOM   3949 C  CA  . LEU B 1 222 ? -7.225  -7.348  -7.842  1.00 7.44  ? 222 LEU B CA  1 
ATOM   3950 C  C   . LEU B 1 222 ? -6.576  -6.621  -9.009  1.00 8.45  ? 222 LEU B C   1 
ATOM   3951 O  O   . LEU B 1 222 ? -6.196  -5.465  -8.861  1.00 7.27  ? 222 LEU B O   1 
ATOM   3952 C  CB  . LEU B 1 222 ? -6.188  -8.296  -7.154  1.00 7.89  ? 222 LEU B CB  1 
ATOM   3953 C  CG  . LEU B 1 222 ? -6.615  -8.543  -5.756  1.00 8.41  ? 222 LEU B CG  1 
ATOM   3954 C  CD1 . LEU B 1 222 ? -5.996  -9.830  -5.167  1.00 10.14 ? 222 LEU B CD1 1 
ATOM   3955 C  CD2 . LEU B 1 222 ? -6.209  -7.443  -4.777  1.00 8.99  ? 222 LEU B CD2 1 
ATOM   3956 N  N   . LEU B 1 223 ? -6.358  -7.306  -10.145 1.00 8.93  ? 223 LEU B N   1 
ATOM   3957 C  CA  . LEU B 1 223 ? -5.750  -6.647  -11.257 1.00 9.45  ? 223 LEU B CA  1 
ATOM   3958 C  C   . LEU B 1 223 ? -6.579  -5.528  -11.750 1.00 10.36 ? 223 LEU B C   1 
ATOM   3959 O  O   . LEU B 1 223 ? -6.002  -4.445  -12.110 1.00 9.41  ? 223 LEU B O   1 
ATOM   3960 C  CB  . LEU B 1 223 ? -5.567  -7.736  -12.385 1.00 10.79 ? 223 LEU B CB  1 
ATOM   3961 C  CG  . LEU B 1 223 ? -4.841  -7.131  -13.573 1.00 13.37 ? 223 LEU B CG  1 
ATOM   3962 C  CD1 . LEU B 1 223 ? -3.464  -6.681  -13.157 1.00 16.34 ? 223 LEU B CD1 1 
ATOM   3963 C  CD2 . LEU B 1 223 ? -4.798  -8.190  -14.699 1.00 15.48 ? 223 LEU B CD2 1 
ATOM   3964 N  N   . ALA B 1 224 ? -7.887  -5.698  -11.771 1.00 9.70  ? 224 ALA B N   1 
ATOM   3965 C  CA  . ALA B 1 224 ? -8.709  -4.596  -12.261 1.00 9.53  ? 224 ALA B CA  1 
ATOM   3966 C  C   . ALA B 1 224 ? -8.601  -3.439  -11.268 1.00 9.49  ? 224 ALA B C   1 
ATOM   3967 O  O   . ALA B 1 224 ? -8.425  -2.288  -11.671 1.00 11.96 ? 224 ALA B O   1 
ATOM   3968 C  CB  . ALA B 1 224 ? -10.150 -5.108  -12.421 1.00 12.40 ? 224 ALA B CB  1 
ATOM   3969 N  N   . LEU B 1 225 ? -8.679  -3.692  -9.949  1.00 8.47  ? 225 LEU B N   1 
ATOM   3970 C  CA  . LEU B 1 225 ? -8.511  -2.643  -8.947  1.00 8.40  ? 225 LEU B CA  1 
ATOM   3971 C  C   . LEU B 1 225 ? -7.209  -1.911  -9.062  1.00 8.91  ? 225 LEU B C   1 
ATOM   3972 O  O   . LEU B 1 225 ? -7.188  -0.690  -9.043  1.00 9.67  ? 225 LEU B O   1 
ATOM   3973 C  CB  . LEU B 1 225 ? -8.692  -3.260  -7.551  1.00 8.76  ? 225 LEU B CB  1 
ATOM   3974 C  CG  . LEU B 1 225 ? -8.426  -2.325  -6.405  1.00 9.47  ? 225 LEU B CG  1 
ATOM   3975 C  CD1 . LEU B 1 225 ? -9.433  -1.158  -6.375  1.00 9.61  ? 225 LEU B CD1 1 
ATOM   3976 C  CD2 . LEU B 1 225 ? -8.497  -3.133  -5.131  1.00 9.86  ? 225 LEU B CD2 1 
ATOM   3977 N  N   . GLU B 1 226 ? -6.134  -2.647  -9.261  1.00 8.50  ? 226 GLU B N   1 
ATOM   3978 C  CA  . GLU B 1 226 ? -4.787  -2.073  -9.392  1.00 8.20  ? 226 GLU B CA  1 
ATOM   3979 C  C   . GLU B 1 226 ? -4.472  -1.351  -10.695 1.00 8.32  ? 226 GLU B C   1 
ATOM   3980 O  O   . GLU B 1 226 ? -3.458  -0.717  -10.746 1.00 11.70 ? 226 GLU B O   1 
ATOM   3981 C  CB  . GLU B 1 226 ? -3.765  -3.231  -9.195  1.00 7.67  ? 226 GLU B CB  1 
ATOM   3982 C  CG  . GLU B 1 226 ? -3.869  -3.876  -7.810  1.00 7.99  ? 226 GLU B CG  1 
ATOM   3983 C  CD  . GLU B 1 226 ? -3.381  -5.318  -7.817  1.00 9.95  ? 226 GLU B CD  1 
ATOM   3984 O  OE1 . GLU B 1 226 ? -3.050  -5.839  -8.907  1.00 10.48 ? 226 GLU B OE1 1 
ATOM   3985 O  OE2 . GLU B 1 226 ? -3.333  -5.938  -6.734  1.00 10.48 ? 226 GLU B OE2 1 
ATOM   3986 N  N   . THR B 1 227 ? -5.304  -1.502  -11.712 1.00 7.40  ? 227 THR B N   1 
ATOM   3987 C  CA  . THR B 1 227 ? -5.047  -0.837  -12.989 1.00 8.68  ? 227 THR B CA  1 
ATOM   3988 C  C   . THR B 1 227 ? -6.161  0.110   -13.359 1.00 10.24 ? 227 THR B C   1 
ATOM   3989 O  O   . THR B 1 227 ? -6.040  0.779   -14.427 1.00 13.69 ? 227 THR B O   1 
ATOM   3990 C  CB  . THR B 1 227 ? -4.915  -1.908  -14.122 1.00 9.60  ? 227 THR B CB  1 
ATOM   3991 O  OG1 . THR B 1 227 ? -6.141  -2.673  -14.237 1.00 10.33 ? 227 THR B OG1 1 
ATOM   3992 C  CG2 . THR B 1 227 ? -3.652  -2.800  -13.906 1.00 8.99  ? 227 THR B CG2 1 
ATOM   3993 N  N   . ALA B 1 228 ? -7.184  0.276   -12.562 1.00 9.67  ? 228 ALA B N   1 
ATOM   3994 C  CA  . ALA B 1 228 ? -8.323  1.064   -13.025 1.00 9.95  ? 228 ALA B CA  1 
ATOM   3995 C  C   . ALA B 1 228 ? -8.127  2.561   -12.716 1.00 10.86 ? 228 ALA B C   1 
ATOM   3996 O  O   . ALA B 1 228 ? -8.864  3.353   -13.355 1.00 13.56 ? 228 ALA B O   1 
ATOM   3997 C  CB  . ALA B 1 228 ? -9.562  0.624   -12.292 1.00 13.53 ? 228 ALA B CB  1 
ATOM   3998 N  N   . LEU B 1 229 ? -7.344  2.975   -11.736 1.00 8.28  ? 229 LEU B N   1 
ATOM   3999 C  CA  . LEU B 1 229 ? -7.494  4.316   -11.186 1.00 7.38  ? 229 LEU B CA  1 
ATOM   4000 C  C   . LEU B 1 229 ? -6.207  5.077   -11.241 1.00 7.07  ? 229 LEU B C   1 
ATOM   4001 O  O   . LEU B 1 229 ? -5.124  4.585   -11.189 1.00 6.83  ? 229 LEU B O   1 
ATOM   4002 C  CB  . LEU B 1 229 ? -7.955  4.226   -9.714  1.00 7.65  ? 229 LEU B CB  1 
ATOM   4003 C  CG  . LEU B 1 229 ? -9.249  3.418   -9.503  1.00 8.61  ? 229 LEU B CG  1 
ATOM   4004 C  CD1 . LEU B 1 229 ? -9.470  3.131   -8.016  1.00 10.36 ? 229 LEU B CD1 1 
ATOM   4005 C  CD2 . LEU B 1 229 ? -10.408 4.247   -10.017 1.00 12.11 ? 229 LEU B CD2 1 
ATOM   4006 N  N   . TYR B 1 230 ? -6.402  6.400   -11.351 1.00 7.08  ? 230 TYR B N   1 
ATOM   4007 C  CA  . TYR B 1 230 ? -5.387  7.402   -11.353 1.00 7.33  ? 230 TYR B CA  1 
ATOM   4008 C  C   . TYR B 1 230 ? -5.581  8.403   -10.234 1.00 7.49  ? 230 TYR B C   1 
ATOM   4009 O  O   . TYR B 1 230 ? -6.709  8.744   -9.858  1.00 7.97  ? 230 TYR B O   1 
ATOM   4010 C  CB  . TYR B 1 230 ? -5.385  8.132   -12.746 1.00 7.48  ? 230 TYR B CB  1 
ATOM   4011 C  CG  . TYR B 1 230 ? -4.778  7.236   -13.770 1.00 8.23  ? 230 TYR B CG  1 
ATOM   4012 C  CD1 . TYR B 1 230 ? -3.443  7.362   -14.110 1.00 9.77  ? 230 TYR B CD1 1 
ATOM   4013 C  CD2 . TYR B 1 230 ? -5.578  6.277   -14.396 1.00 9.76  ? 230 TYR B CD2 1 
ATOM   4014 C  CE1 . TYR B 1 230 ? -2.879  6.439   -15.002 1.00 12.06 ? 230 TYR B CE1 1 
ATOM   4015 C  CE2 . TYR B 1 230 ? -4.972  5.378   -15.262 1.00 11.05 ? 230 TYR B CE2 1 
ATOM   4016 C  CZ  . TYR B 1 230 ? -3.668  5.469   -15.505 1.00 11.20 ? 230 TYR B CZ  1 
ATOM   4017 O  OH  . TYR B 1 230 ? -3.171  4.534   -16.450 1.00 20.02 ? 230 TYR B OH  1 
ATOM   4018 N  N   . CYS B 1 231 ? -4.469  8.902   -9.708  1.00 8.05  ? 231 CYS B N   1 
ATOM   4019 C  CA  . CYS B 1 231 ? -4.525  9.922   -8.654  1.00 9.22  ? 231 CYS B CA  1 
ATOM   4020 C  C   . CYS B 1 231 ? -4.770  11.336  -9.259  1.00 9.59  ? 231 CYS B C   1 
ATOM   4021 O  O   . CYS B 1 231 ? -5.033  12.319  -8.571  1.00 10.14 ? 231 CYS B O   1 
ATOM   4022 C  CB  . CYS B 1 231 ? -3.121  10.046  -8.026  1.00 9.89  ? 231 CYS B CB  1 
ATOM   4023 S  SG  . CYS B 1 231 ? -2.634  8.538   -7.114  1.00 13.89 ? 231 CYS B SG  1 
ATOM   4024 N  N   . THR B 1 232 ? -4.587  11.418  -10.567 1.00 8.04  ? 232 THR B N   1 
ATOM   4025 C  CA  . THR B 1 232 ? -4.546  12.724  -11.276 1.00 7.75  ? 232 THR B CA  1 
ATOM   4026 C  C   . THR B 1 232 ? -5.809  12.938  -12.049 1.00 8.26  ? 232 THR B C   1 
ATOM   4027 O  O   . THR B 1 232 ? -6.581  12.030  -12.388 1.00 7.45  ? 232 THR B O   1 
ATOM   4028 C  CB  . THR B 1 232 ? -3.289  12.671  -12.214 1.00 7.51  ? 232 THR B CB  1 
ATOM   4029 O  OG1 . THR B 1 232 ? -3.154  11.342  -12.825 1.00 8.85  ? 232 THR B OG1 1 
ATOM   4030 C  CG2 . THR B 1 232 ? -2.028  13.067  -11.362 1.00 9.28  ? 232 THR B CG2 1 
ATOM   4031 N  N   . HIS B 1 233 ? -6.021  14.204  -12.436 1.00 8.35  ? 233 HIS B N   1 
ATOM   4032 C  CA  . HIS B 1 233 ? -7.130  14.532  -13.303 1.00 8.49  ? 233 HIS B CA  1 
ATOM   4033 C  C   . HIS B 1 233 ? -7.011  14.021  -14.724 1.00 8.90  ? 233 HIS B C   1 
ATOM   4034 O  O   . HIS B 1 233 ? -5.922  13.701  -15.183 1.00 8.66  ? 233 HIS B O   1 
ATOM   4035 C  CB  . HIS B 1 233 ? -7.250  16.063  -13.410 1.00 11.06 ? 233 HIS B CB  1 
ATOM   4036 C  CG  . HIS B 1 233 ? -7.773  16.714  -12.171 1.00 13.34 ? 233 HIS B CG  1 
ATOM   4037 N  ND1 . HIS B 1 233 ? -7.064  17.628  -11.502 1.00 22.92 ? 233 HIS B ND1 1 
ATOM   4038 C  CD2 . HIS B 1 233 ? -8.979  16.579  -11.503 1.00 16.64 ? 233 HIS B CD2 1 
ATOM   4039 C  CE1 . HIS B 1 233 ? -7.783  18.103  -10.449 1.00 20.67 ? 233 HIS B CE1 1 
ATOM   4040 N  NE2 . HIS B 1 233 ? -8.953  17.463  -10.426 1.00 18.61 ? 233 HIS B NE2 1 
ATOM   4041 N  N   . MET B 1 234 ? -8.146  13.806  -15.375 1.00 8.52  ? 234 MET B N   1 
ATOM   4042 C  CA  . MET B 1 234 ? -8.188  13.291  -16.747 1.00 9.19  ? 234 MET B CA  1 
ATOM   4043 C  C   . MET B 1 234 ? -7.247  14.110  -17.696 1.00 9.79  ? 234 MET B C   1 
ATOM   4044 O  O   . MET B 1 234 ? -6.598  13.538  -18.576 1.00 10.53 ? 234 MET B O   1 
ATOM   4045 C  CB  . MET B 1 234 ? -9.623  13.365  -17.223 1.00 10.89 ? 234 MET B CB  1 
ATOM   4046 C  CG  . MET B 1 234 ? -9.776  12.689  -18.572 1.00 12.31 ? 234 MET B CG  1 
ATOM   4047 S  SD  . MET B 1 234 ? -11.586 12.526  -18.850 1.00 19.68 ? 234 MET B SD  1 
ATOM   4048 C  CE  . MET B 1 234 ? -11.527 11.548  -20.339 1.00 17.45 ? 234 MET B CE  1 
ATOM   4049 N  N   . ASP B 1 235 ? -7.118  15.382  -17.457 1.00 10.87 ? 235 ASP B N   1 
ATOM   4050 C  CA  . ASP B 1 235 ? -6.261  16.169  -18.345 1.00 12.65 ? 235 ASP B CA  1 
ATOM   4051 C  C   . ASP B 1 235 ? -4.905  16.470  -17.838 1.00 13.20 ? 235 ASP B C   1 
ATOM   4052 O  O   . ASP B 1 235 ? -4.186  17.327  -18.386 1.00 15.54 ? 235 ASP B O   1 
ATOM   4053 C  CB  . ASP B 1 235 ? -6.967  17.474  -18.697 1.00 17.78 ? 235 ASP B CB  1 
ATOM   4054 C  CG  . ASP B 1 235 ? -7.086  18.413  -17.520 1.00 21.86 ? 235 ASP B CG  1 
ATOM   4055 O  OD1 . ASP B 1 235 ? -6.685  18.088  -16.354 1.00 27.64 ? 235 ASP B OD1 1 
ATOM   4056 O  OD2 . ASP B 1 235 ? -7.626  19.520  -17.781 1.00 34.56 ? 235 ASP B OD2 1 
ATOM   4057 N  N   . ASP B 1 236 ? -4.404  15.726  -16.871 1.00 10.54 ? 236 ASP B N   1 
ATOM   4058 C  CA  . ASP B 1 236 ? -3.145  16.065  -16.279 1.00 10.40 ? 236 ASP B CA  1 
ATOM   4059 C  C   . ASP B 1 236 ? -2.019  15.562  -17.190 1.00 10.35 ? 236 ASP B C   1 
ATOM   4060 O  O   . ASP B 1 236 ? -2.017  14.389  -17.587 1.00 11.64 ? 236 ASP B O   1 
ATOM   4061 C  CB  . ASP B 1 236 ? -2.967  15.331  -14.899 1.00 11.64 ? 236 ASP B CB  1 
ATOM   4062 C  CG  . ASP B 1 236 ? -1.867  15.954  -14.071 1.00 13.43 ? 236 ASP B CG  1 
ATOM   4063 O  OD1 . ASP B 1 236 ? -0.770  16.158  -14.561 1.00 13.67 ? 236 ASP B OD1 1 
ATOM   4064 O  OD2 . ASP B 1 236 ? -2.017  16.232  -12.852 1.00 16.64 ? 236 ASP B OD2 1 
ATOM   4065 N  N   . PRO B 1 237 ? -1.054  16.407  -17.572 1.00 10.77 ? 237 PRO B N   1 
ATOM   4066 C  CA  . PRO B 1 237 ? -0.002  15.936  -18.443 1.00 11.08 ? 237 PRO B CA  1 
ATOM   4067 C  C   . PRO B 1 237 ? 1.079   15.077  -17.729 1.00 10.41 ? 237 PRO B C   1 
ATOM   4068 O  O   . PRO B 1 237 ? 2.024   14.522  -18.364 1.00 11.30 ? 237 PRO B O   1 
ATOM   4069 C  CB  . PRO B 1 237 ? 0.569   17.261  -18.971 1.00 10.91 ? 237 PRO B CB  1 
ATOM   4070 C  CG  . PRO B 1 237 ? 0.367   18.193  -17.753 1.00 12.17 ? 237 PRO B CG  1 
ATOM   4071 C  CD  . PRO B 1 237 ? -1.010  17.859  -17.283 1.00 10.49 ? 237 PRO B CD  1 
ATOM   4072 N  N   A SER B 1 238 ? 0.983   14.994  -16.388 0.50 10.29 ? 238 SER B N   1 
ATOM   4073 N  N   B SER B 1 238 ? 0.997   14.925  -16.400 0.50 10.00 ? 238 SER B N   1 
ATOM   4074 C  CA  A SER B 1 238 ? 1.819   14.078  -15.571 0.50 10.60 ? 238 SER B CA  1 
ATOM   4075 C  CA  B SER B 1 238 ? 1.898   13.975  -15.680 0.50 10.17 ? 238 SER B CA  1 
ATOM   4076 C  C   A SER B 1 238 ? 0.904   13.100  -14.829 0.50 9.59  ? 238 SER B C   1 
ATOM   4077 C  C   B SER B 1 238 ? 1.091   12.981  -14.867 0.50 9.53  ? 238 SER B C   1 
ATOM   4078 O  O   A SER B 1 238 ? 0.697   13.254  -13.602 0.50 10.43 ? 238 SER B O   1 
ATOM   4079 O  O   B SER B 1 238 ? 1.144   12.995  -13.648 0.50 9.77  ? 238 SER B O   1 
ATOM   4080 C  CB  A SER B 1 238 ? 2.657   14.807  -14.518 0.50 11.08 ? 238 SER B CB  1 
ATOM   4081 C  CB  B SER B 1 238 ? 2.818   14.688  -14.711 0.50 10.51 ? 238 SER B CB  1 
ATOM   4082 O  OG  A SER B 1 238 ? 3.819   14.039  -14.229 0.50 14.64 ? 238 SER B OG  1 
ATOM   4083 O  OG  B SER B 1 238 ? 3.637   15.622  -15.417 0.50 12.24 ? 238 SER B OG  1 
ATOM   4084 N  N   . PRO B 1 239 ? 0.407   12.080  -15.540 1.00 9.16  ? 239 PRO B N   1 
ATOM   4085 C  CA  . PRO B 1 239 ? -0.519  11.155  -14.825 1.00 9.01  ? 239 PRO B CA  1 
ATOM   4086 C  C   . PRO B 1 239 ? 0.213   10.286  -13.851 1.00 9.38  ? 239 PRO B C   1 
ATOM   4087 O  O   . PRO B 1 239 ? 1.410   9.945   -14.025 1.00 9.54  ? 239 PRO B O   1 
ATOM   4088 C  CB  . PRO B 1 239 ? -1.013  10.221  -15.913 1.00 10.89 ? 239 PRO B CB  1 
ATOM   4089 C  CG  . PRO B 1 239 ? -0.613  10.862  -17.173 1.00 13.19 ? 239 PRO B CG  1 
ATOM   4090 C  CD  . PRO B 1 239 ? 0.517   11.820  -16.964 1.00 10.50 ? 239 PRO B CD  1 
ATOM   4091 N  N   . ARG B 1 240 ? -0.522  9.914   -12.784 1.00 8.45  ? 240 ARG B N   1 
ATOM   4092 C  CA  . ARG B 1 240 ? 0.058   9.058   -11.731 1.00 9.61  ? 240 ARG B CA  1 
ATOM   4093 C  C   . ARG B 1 240 ? -0.971  7.965   -11.419 1.00 7.37  ? 240 ARG B C   1 
ATOM   4094 O  O   . ARG B 1 240 ? -2.128  8.304   -11.111 1.00 9.14  ? 240 ARG B O   1 
ATOM   4095 C  CB  . ARG B 1 240 ? 0.381   9.796   -10.458 1.00 10.16 ? 240 ARG B CB  1 
ATOM   4096 C  CG  . ARG B 1 240 ? 1.592   10.740  -10.673 1.00 12.10 ? 240 ARG B CG  1 
ATOM   4097 C  CD  . ARG B 1 240 ? 1.905   11.499  -9.383  1.00 14.13 ? 240 ARG B CD  1 
ATOM   4098 N  NE  . ARG B 1 240 ? 0.826   12.428  -9.072  1.00 15.77 ? 240 ARG B NE  1 
ATOM   4099 C  CZ  . ARG B 1 240 ? -0.018  12.284  -8.034  1.00 15.20 ? 240 ARG B CZ  1 
ATOM   4100 N  NH1 . ARG B 1 240 ? 0.046   11.186  -7.276  1.00 14.93 ? 240 ARG B NH1 1 
ATOM   4101 N  NH2 . ARG B 1 240 ? -0.965  13.173  -7.865  1.00 19.71 ? 240 ARG B NH2 1 
ATOM   4102 N  N   . GLU B 1 241 ? -0.566  6.715   -11.534 1.00 8.18  ? 241 GLU B N   1 
ATOM   4103 C  CA  . GLU B 1 241 ? -1.501  5.595   -11.261 1.00 7.89  ? 241 GLU B CA  1 
ATOM   4104 C  C   . GLU B 1 241 ? -1.751  5.526   -9.741  1.00 6.90  ? 241 GLU B C   1 
ATOM   4105 O  O   . GLU B 1 241 ? -0.818  5.718   -8.915  1.00 8.25  ? 241 GLU B O   1 
ATOM   4106 C  CB  . GLU B 1 241 ? -0.795  4.338   -11.642 1.00 10.89 ? 241 GLU B CB  1 
ATOM   4107 C  CG  . GLU B 1 241 ? -0.708  4.224   -13.169 1.00 11.69 ? 241 GLU B CG  1 
ATOM   4108 C  CD  . GLU B 1 241 ? 0.230   3.096   -13.516 1.00 18.94 ? 241 GLU B CD  1 
ATOM   4109 O  OE1 . GLU B 1 241 ? 1.372   3.101   -12.970 1.00 26.60 ? 241 GLU B OE1 1 
ATOM   4110 O  OE2 . GLU B 1 241 ? -0.190  2.235   -14.293 1.00 24.84 ? 241 GLU B OE2 1 
ATOM   4111 N  N   . MET B 1 242 ? -2.986  5.155   -9.398  1.00 6.21  ? 242 MET B N   1 
ATOM   4112 C  CA  . MET B 1 242 ? -3.313  4.972   -7.965  1.00 6.65  ? 242 MET B CA  1 
ATOM   4113 C  C   . MET B 1 242 ? -3.019  3.492   -7.583  1.00 6.47  ? 242 MET B C   1 
ATOM   4114 O  O   . MET B 1 242 ? -3.857  2.596   -7.812  1.00 6.48  ? 242 MET B O   1 
ATOM   4115 C  CB  . MET B 1 242 ? -4.781  5.334   -7.767  1.00 6.98  ? 242 MET B CB  1 
ATOM   4116 C  CG  . MET B 1 242 ? -5.170  5.324   -6.287  1.00 7.25  ? 242 MET B CG  1 
ATOM   4117 S  SD  . MET B 1 242 ? -6.878  5.682   -5.961  1.00 8.35  ? 242 MET B SD  1 
ATOM   4118 C  CE  . MET B 1 242 ? -6.967  7.426   -6.536  1.00 8.69  ? 242 MET B CE  1 
ATOM   4119 N  N   . ILE B 1 243 ? -1.799  3.343   -7.124  1.00 5.92  ? 243 ILE B N   1 
ATOM   4120 C  CA  . ILE B 1 243 ? -1.260  2.045   -6.752  1.00 6.07  ? 243 ILE B CA  1 
ATOM   4121 C  C   . ILE B 1 243 ? -0.454  2.236   -5.511  1.00 4.98  ? 243 ILE B C   1 
ATOM   4122 O  O   . ILE B 1 243 ? -0.055  3.342   -5.153  1.00 6.23  ? 243 ILE B O   1 
ATOM   4123 C  CB  . ILE B 1 243 ? -0.352  1.406   -7.850  1.00 6.36  ? 243 ILE B CB  1 
ATOM   4124 C  CG1 . ILE B 1 243 ? 0.705   2.464   -8.276  1.00 7.86  ? 243 ILE B CG1 1 
ATOM   4125 C  CG2 . ILE B 1 243 ? -1.163  0.999   -9.064  1.00 8.25  ? 243 ILE B CG2 1 
ATOM   4126 C  CD1 . ILE B 1 243 ? 1.759   1.879   -9.239  1.00 10.50 ? 243 ILE B CD1 1 
ATOM   4127 N  N   . ASN B 1 244 ? -0.259  1.097   -4.777  1.00 5.29  ? 244 ASN B N   1 
ATOM   4128 C  CA  . ASN B 1 244 ? 0.549   1.118   -3.577  1.00 5.55  ? 244 ASN B CA  1 
ATOM   4129 C  C   . ASN B 1 244 ? 0.131   2.142   -2.584  1.00 5.47  ? 244 ASN B C   1 
ATOM   4130 O  O   . ASN B 1 244 ? 0.928   2.808   -1.976  1.00 5.17  ? 244 ASN B O   1 
ATOM   4131 C  CB  . ASN B 1 244 ? 2.066   1.217   -3.932  1.00 7.04  ? 244 ASN B CB  1 
ATOM   4132 C  CG  . ASN B 1 244 ? 2.438   0.190   -4.925  1.00 8.64  ? 244 ASN B CG  1 
ATOM   4133 O  OD1 . ASN B 1 244 ? 2.064   -1.000  -4.868  1.00 9.86  ? 244 ASN B OD1 1 
ATOM   4134 N  ND2 . ASN B 1 244 ? 3.194   0.680   -5.966  1.00 11.87 ? 244 ASN B ND2 1 
ATOM   4135 N  N   . ASN B 1 245 ? -1.194  2.299   -2.447  1.00 4.65  ? 245 ASN B N   1 
ATOM   4136 C  CA  . ASN B 1 245 ? -1.733  3.341   -1.599  1.00 4.65  ? 245 ASN B CA  1 
ATOM   4137 C  C   . ASN B 1 245 ? -2.000  2.865   -0.201  1.00 4.92  ? 245 ASN B C   1 
ATOM   4138 O  O   . ASN B 1 245 ? -3.102  2.896   0.325   1.00 5.78  ? 245 ASN B O   1 
ATOM   4139 C  CB  . ASN B 1 245 ? -3.070  3.927   -2.265  1.00 5.39  ? 245 ASN B CB  1 
ATOM   4140 C  CG  . ASN B 1 245 ? -4.146  2.923   -2.364  1.00 5.76  ? 245 ASN B CG  1 
ATOM   4141 O  OD1 . ASN B 1 245 ? -3.933  1.762   -2.591  1.00 5.97  ? 245 ASN B OD1 1 
ATOM   4142 N  ND2 . ASN B 1 245 ? -5.396  3.410   -2.455  1.00 7.18  ? 245 ASN B ND2 1 
ATOM   4143 N  N   . PHE B 1 246 ? -0.930  2.413   0.409   1.00 4.60  ? 246 PHE B N   1 
ATOM   4144 C  CA  . PHE B 1 246 ? -0.932  1.976   1.826   1.00 5.22  ? 246 PHE B CA  1 
ATOM   4145 C  C   . PHE B 1 246 ? 0.230   2.567   2.517   1.00 5.74  ? 246 PHE B C   1 
ATOM   4146 O  O   . PHE B 1 246 ? 1.308   2.716   1.951   1.00 5.53  ? 246 PHE B O   1 
ATOM   4147 C  CB  . PHE B 1 246 ? -0.912  0.394   1.876   1.00 6.27  ? 246 PHE B CB  1 
ATOM   4148 C  CG  . PHE B 1 246 ? 0.351   -0.226  1.297   1.00 5.71  ? 246 PHE B CG  1 
ATOM   4149 C  CD1 . PHE B 1 246 ? 1.425   -0.603  2.128   1.00 6.57  ? 246 PHE B CD1 1 
ATOM   4150 C  CD2 . PHE B 1 246 ? 0.434   -0.519  -0.077  1.00 5.57  ? 246 PHE B CD2 1 
ATOM   4151 C  CE1 . PHE B 1 246 ? 2.585   -1.095  1.563   1.00 7.51  ? 246 PHE B CE1 1 
ATOM   4152 C  CE2 . PHE B 1 246 ? 1.588   -1.054  -0.652  1.00 5.86  ? 246 PHE B CE2 1 
ATOM   4153 C  CZ  . PHE B 1 246 ? 2.671   -1.332  0.214   1.00 6.94  ? 246 PHE B CZ  1 
ATOM   4154 N  N   . ARG B 1 247 ? 0.045   2.873   3.775   1.00 4.63  ? 247 ARG B N   1 
ATOM   4155 C  CA  . ARG B 1 247 ? 1.156   3.376   4.629   1.00 5.29  ? 247 ARG B CA  1 
ATOM   4156 C  C   . ARG B 1 247 ? 1.883   2.174   5.239   1.00 5.46  ? 247 ARG B C   1 
ATOM   4157 O  O   . ARG B 1 247 ? 1.245   1.157   5.564   1.00 5.74  ? 247 ARG B O   1 
ATOM   4158 C  CB  . ARG B 1 247 ? 0.567   4.219   5.777   1.00 4.89  ? 247 ARG B CB  1 
ATOM   4159 C  CG  . ARG B 1 247 ? 1.557   5.108   6.489   1.00 4.27  ? 247 ARG B CG  1 
ATOM   4160 C  CD  . ARG B 1 247 ? 0.844   5.778   7.613   1.00 5.19  ? 247 ARG B CD  1 
ATOM   4161 N  NE  . ARG B 1 247 ? 1.660   6.856   8.162   1.00 5.68  ? 247 ARG B NE  1 
ATOM   4162 C  CZ  . ARG B 1 247 ? 1.367   7.545   9.259   1.00 5.28  ? 247 ARG B CZ  1 
ATOM   4163 N  NH1 . ARG B 1 247 ? 0.263   7.282   9.946   1.00 5.56  ? 247 ARG B NH1 1 
ATOM   4164 N  NH2 . ARG B 1 247 ? 2.187   8.501   9.669   1.00 6.33  ? 247 ARG B NH2 1 
ATOM   4165 N  N   . GLN B 1 248 ? 3.212   2.313   5.456   1.00 5.30  ? 248 GLN B N   1 
ATOM   4166 C  CA  . GLN B 1 248 ? 3.941   1.304   6.230   1.00 6.06  ? 248 GLN B CA  1 
ATOM   4167 C  C   . GLN B 1 248 ? 3.430   1.260   7.628   1.00 6.17  ? 248 GLN B C   1 
ATOM   4168 O  O   . GLN B 1 248 ? 2.916   2.198   8.203   1.00 6.13  ? 248 GLN B O   1 
ATOM   4169 C  CB  . GLN B 1 248 ? 5.438   1.661   6.290   1.00 5.66  ? 248 GLN B CB  1 
ATOM   4170 C  CG  . GLN B 1 248 ? 6.112   1.707   4.899   1.00 6.15  ? 248 GLN B CG  1 
ATOM   4171 C  CD  . GLN B 1 248 ? 6.161   0.345   4.293   1.00 7.07  ? 248 GLN B CD  1 
ATOM   4172 O  OE1 . GLN B 1 248 ? 5.279   -0.018  3.479   1.00 8.70  ? 248 GLN B OE1 1 
ATOM   4173 N  NE2 . GLN B 1 248 ? 7.185   -0.455  4.614   1.00 8.23  ? 248 GLN B NE2 1 
ATOM   4174 N  N   . VAL B 1 249 ? 3.632   0.073   8.220   1.00 5.73  ? 249 VAL B N   1 
ATOM   4175 C  CA  . VAL B 1 249 ? 3.237   -0.024  9.682   1.00 6.04  ? 249 VAL B CA  1 
ATOM   4176 C  C   . VAL B 1 249 ? 4.141   0.795   10.578  1.00 5.80  ? 249 VAL B C   1 
ATOM   4177 O  O   . VAL B 1 249 ? 5.301   1.124   10.229  1.00 5.72  ? 249 VAL B O   1 
ATOM   4178 C  CB  . VAL B 1 249 ? 3.277   -1.473  10.176  1.00 6.99  ? 249 VAL B CB  1 
ATOM   4179 C  CG1 . VAL B 1 249 ? 2.201   -2.282  9.470   1.00 7.25  ? 249 VAL B CG1 1 
ATOM   4180 C  CG2 . VAL B 1 249 ? 4.649   -2.107  9.991   1.00 7.93  ? 249 VAL B CG2 1 
ATOM   4181 N  N   . GLN B 1 250 ? 3.549   1.225   11.653  1.00 5.83  ? 250 GLN B N   1 
ATOM   4182 C  CA  . GLN B 1 250 ? 4.061   2.225   12.589  1.00 6.10  ? 250 GLN B CA  1 
ATOM   4183 C  C   . GLN B 1 250 ? 4.625   1.563   13.842  1.00 7.59  ? 250 GLN B C   1 
ATOM   4184 O  O   . GLN B 1 250 ? 4.117   0.495   14.226  1.00 8.61  ? 250 GLN B O   1 
ATOM   4185 C  CB  . GLN B 1 250 ? 2.939   3.190   13.008  1.00 6.19  ? 250 GLN B CB  1 
ATOM   4186 C  CG  . GLN B 1 250 ? 2.360   3.883   11.777  1.00 6.64  ? 250 GLN B CG  1 
ATOM   4187 C  CD  . GLN B 1 250 ? 3.266   4.773   10.994  1.00 6.78  ? 250 GLN B CD  1 
ATOM   4188 O  OE1 . GLN B 1 250 ? 3.690   5.836   11.574  1.00 8.16  ? 250 GLN B OE1 1 
ATOM   4189 N  NE2 . GLN B 1 250 ? 3.508   4.487   9.729   1.00 6.14  ? 250 GLN B NE2 1 
ATOM   4190 N  N   . LYS B 1 251 ? 5.533   2.247   14.521  1.00 6.87  ? 251 LYS B N   1 
ATOM   4191 C  CA  . LYS B 1 251 ? 5.931   1.743   15.869  1.00 8.01  ? 251 LYS B CA  1 
ATOM   4192 C  C   . LYS B 1 251 ? 4.716   1.688   16.772  1.00 9.70  ? 251 LYS B C   1 
ATOM   4193 O  O   . LYS B 1 251 ? 3.800   2.510   16.734  1.00 9.49  ? 251 LYS B O   1 
ATOM   4194 C  CB  . LYS B 1 251 ? 6.941   2.696   16.495  1.00 11.20 ? 251 LYS B CB  1 
ATOM   4195 C  CG  . LYS B 1 251 ? 8.305   2.714   15.817  1.00 13.17 ? 251 LYS B CG  1 
ATOM   4196 C  CD  . LYS B 1 251 ? 9.184   1.639   16.330  1.00 13.99 ? 251 LYS B CD  1 
ATOM   4197 C  CE  . LYS B 1 251 ? 10.699  1.806   16.004  1.00 11.94 ? 251 LYS B CE  1 
ATOM   4198 N  NZ  . LYS B 1 251 ? 10.852  1.822   14.489  1.00 10.66 ? 251 LYS B NZ  1 
ATOM   4199 N  N   . PHE B 1 252 ? 4.695   0.691   17.669  1.00 10.86 ? 252 PHE B N   1 
ATOM   4200 C  CA  . PHE B 1 252 ? 3.568   0.541   18.579  1.00 12.24 ? 252 PHE B CA  1 
ATOM   4201 C  C   . PHE B 1 252 ? 4.098   -0.146  19.755  1.00 18.10 ? 252 PHE B C   1 
ATOM   4202 O  O   . PHE B 1 252 ? 4.233   -1.337  19.781  1.00 19.21 ? 252 PHE B O   1 
ATOM   4203 C  CB  . PHE B 1 252 ? 2.563   -0.418  17.929  1.00 15.40 ? 252 PHE B CB  1 
ATOM   4204 C  CG  . PHE B 1 252 ? 1.266   -0.545  18.668  1.00 13.87 ? 252 PHE B CG  1 
ATOM   4205 C  CD1 . PHE B 1 252 ? 0.248   0.403   18.509  1.00 13.51 ? 252 PHE B CD1 1 
ATOM   4206 C  CD2 . PHE B 1 252 ? 1.054   -1.643  19.496  1.00 17.33 ? 252 PHE B CD2 1 
ATOM   4207 C  CE1 . PHE B 1 252 ? -1.030  0.320   19.198  1.00 17.80 ? 252 PHE B CE1 1 
ATOM   4208 C  CE2 . PHE B 1 252 ? -0.206  -1.784  20.130  1.00 18.98 ? 252 PHE B CE2 1 
ATOM   4209 C  CZ  . PHE B 1 252 ? -1.229  -0.789  20.027  1.00 16.95 ? 252 PHE B CZ  1 
ATOM   4210 N  N   . ASP B 1 253 ? 4.441   0.694   20.738  1.00 19.99 ? 253 ASP B N   1 
ATOM   4211 C  CA  . ASP B 1 253 ? 5.223   0.314   21.936  1.00 26.56 ? 253 ASP B CA  1 
ATOM   4212 C  C   . ASP B 1 253 ? 4.571   1.104   23.035  1.00 25.94 ? 253 ASP B C   1 
ATOM   4213 O  O   . ASP B 1 253 ? 4.122   2.258   22.851  1.00 31.80 ? 253 ASP B O   1 
ATOM   4214 C  CB  . ASP B 1 253 ? 6.673   0.815   21.836  1.00 30.89 ? 253 ASP B CB  1 
ATOM   4215 C  CG  . ASP B 1 253 ? 7.410   0.318   20.556  1.00 41.45 ? 253 ASP B CG  1 
ATOM   4216 O  OD1 . ASP B 1 253 ? 7.609   -0.928  20.374  1.00 52.30 ? 253 ASP B OD1 1 
ATOM   4217 O  OD2 . ASP B 1 253 ? 7.812   1.183   19.732  1.00 33.86 ? 253 ASP B OD2 1 
ATOM   4218 N  N   . GLU B 1 254 ? 4.514   0.467   24.179  1.00 33.01 ? 254 GLU B N   1 
ATOM   4219 C  CA  . GLU B 1 254 ? 3.608   0.921   25.199  1.00 35.20 ? 254 GLU B CA  1 
ATOM   4220 C  C   . GLU B 1 254 ? 2.130   0.555   24.822  1.00 35.18 ? 254 GLU B C   1 
ATOM   4221 O  O   . GLU B 1 254 ? 1.413   0.154   25.709  1.00 42.17 ? 254 GLU B O   1 
ATOM   4222 C  CB  . GLU B 1 254 ? 3.828   2.421   25.571  1.00 41.07 ? 254 GLU B CB  1 
ATOM   4223 C  CG  . GLU B 1 254 ? 5.249   3.025   25.472  1.00 46.46 ? 254 GLU B CG  1 
ATOM   4224 C  CD  . GLU B 1 254 ? 6.386   2.135   25.981  1.00 57.74 ? 254 GLU B CD  1 
ATOM   4225 O  OE1 . GLU B 1 254 ? 6.230   1.550   27.088  1.00 60.99 ? 254 GLU B OE1 1 
ATOM   4226 O  OE2 . GLU B 1 254 ? 7.445   2.035   25.273  1.00 54.92 ? 254 GLU B OE2 1 
ATOM   4227 N  N   A ARG B 1 255 ? 1.746   0.623   23.544  0.50 30.09 ? 255 ARG B N   1 
ATOM   4228 N  N   B ARG B 1 255 ? 1.689   0.724   23.551  0.50 29.56 ? 255 ARG B N   1 
ATOM   4229 C  CA  A ARG B 1 255 ? 0.375   0.304   23.146  0.50 24.09 ? 255 ARG B CA  1 
ATOM   4230 C  CA  B ARG B 1 255 ? 0.292   0.367   23.143  0.50 23.31 ? 255 ARG B CA  1 
ATOM   4231 C  C   A ARG B 1 255 ? 0.088   -1.269  23.172  0.50 25.34 ? 255 ARG B C   1 
ATOM   4232 C  C   B ARG B 1 255 ? 0.076   -1.224  23.193  0.50 25.11 ? 255 ARG B C   1 
ATOM   4233 O  O   A ARG B 1 255 ? 0.998   -2.101  22.894  0.50 26.31 ? 255 ARG B O   1 
ATOM   4234 O  O   B ARG B 1 255 ? 1.023   -2.020  22.951  0.50 27.27 ? 255 ARG B O   1 
ATOM   4235 C  CB  A ARG B 1 255 ? 0.083   1.027   21.811  0.50 24.24 ? 255 ARG B CB  1 
ATOM   4236 C  CB  B ARG B 1 255 ? -0.134  1.035   21.772  0.50 22.55 ? 255 ARG B CB  1 
ATOM   4237 C  CG  A ARG B 1 255 ? 0.384   2.553   21.811  0.50 22.82 ? 255 ARG B CG  1 
ATOM   4238 C  CG  B ARG B 1 255 ? -0.476  2.572   21.666  0.50 21.67 ? 255 ARG B CG  1 
ATOM   4239 C  CD  A ARG B 1 255 ? 0.562   3.144   20.413  0.50 20.61 ? 255 ARG B CD  1 
ATOM   4240 C  CD  B ARG B 1 255 ? -0.987  2.956   20.223  0.50 19.14 ? 255 ARG B CD  1 
ATOM   4241 N  NE  A ARG B 1 255 ? -0.692  3.195   19.611  0.50 19.34 ? 255 ARG B NE  1 
ATOM   4242 N  NE  B ARG B 1 255 ? 0.094   3.079   19.197  0.50 19.78 ? 255 ARG B NE  1 
ATOM   4243 C  CZ  A ARG B 1 255 ? -0.725  3.254   18.273  0.50 19.76 ? 255 ARG B CZ  1 
ATOM   4244 C  CZ  B ARG B 1 255 ? -0.055  3.245   17.861  0.50 16.92 ? 255 ARG B CZ  1 
ATOM   4245 N  NH1 A ARG B 1 255 ? 0.425   3.262   17.539  0.50 22.01 ? 255 ARG B NH1 1 
ATOM   4246 N  NH1 B ARG B 1 255 ? -1.329  3.302   17.355  0.50 14.64 ? 255 ARG B NH1 1 
ATOM   4247 N  NH2 A ARG B 1 255 ? -1.900  3.301   17.639  0.50 14.97 ? 255 ARG B NH2 1 
ATOM   4248 N  NH2 B ARG B 1 255 ? 1.073   3.362   17.033  0.50 11.12 ? 255 ARG B NH2 1 
ATOM   4249 N  N   . LEU B 1 256 ? -1.124  -1.682  23.591  1.00 21.55 ? 256 LEU B N   1 
ATOM   4250 C  CA  . LEU B 1 256 ? -1.595  -3.065  23.339  1.00 18.22 ? 256 LEU B CA  1 
ATOM   4251 C  C   . LEU B 1 256 ? -2.810  -3.037  22.363  1.00 15.23 ? 256 LEU B C   1 
ATOM   4252 O  O   . LEU B 1 256 ? -3.601  -2.029  22.264  1.00 16.41 ? 256 LEU B O   1 
ATOM   4253 C  CB  . LEU B 1 256 ? -2.029  -3.789  24.617  1.00 23.27 ? 256 LEU B CB  1 
ATOM   4254 C  CG  . LEU B 1 256 ? -1.013  -3.950  25.687  1.00 24.62 ? 256 LEU B CG  1 
ATOM   4255 C  CD1 . LEU B 1 256 ? -1.589  -4.846  26.791  1.00 30.74 ? 256 LEU B CD1 1 
ATOM   4256 C  CD2 . LEU B 1 256 ? 0.313   -4.477  25.057  1.00 28.67 ? 256 LEU B CD2 1 
ATOM   4257 N  N   . VAL B 1 257 ? -2.931  -4.168  21.675  1.00 11.52 ? 257 VAL B N   1 
ATOM   4258 C  CA  . VAL B 1 257 ? -4.065  -4.423  20.818  1.00 9.85  ? 257 VAL B CA  1 
ATOM   4259 C  C   . VAL B 1 257 ? -4.905  -5.460  21.559  1.00 9.10  ? 257 VAL B C   1 
ATOM   4260 O  O   . VAL B 1 257 ? -4.375  -6.527  21.985  1.00 10.88 ? 257 VAL B O   1 
ATOM   4261 C  CB  . VAL B 1 257 ? -3.616  -5.030  19.471  1.00 9.23  ? 257 VAL B CB  1 
ATOM   4262 C  CG1 . VAL B 1 257 ? -4.771  -5.399  18.598  1.00 9.95  ? 257 VAL B CG1 1 
ATOM   4263 C  CG2 . VAL B 1 257 ? -2.770  -4.032  18.713  1.00 10.20 ? 257 VAL B CG2 1 
ATOM   4264 N  N   . TYR B 1 258 ? -6.153  -5.156  21.735  1.00 8.77  ? 258 TYR B N   1 
ATOM   4265 C  CA  . TYR B 1 258 ? -7.071  -6.060  22.457  1.00 8.38  ? 258 TYR B CA  1 
ATOM   4266 C  C   . TYR B 1 258 ? -7.766  -6.969  21.536  1.00 9.04  ? 258 TYR B C   1 
ATOM   4267 O  O   . TYR B 1 258 ? -8.135  -6.573  20.411  1.00 9.93  ? 258 TYR B O   1 
ATOM   4268 C  CB  . TYR B 1 258 ? -8.032  -5.204  23.277  1.00 10.37 ? 258 TYR B CB  1 
ATOM   4269 C  CG  . TYR B 1 258 ? -7.265  -4.305  24.232  1.00 13.58 ? 258 TYR B CG  1 
ATOM   4270 C  CD1 . TYR B 1 258 ? -6.755  -4.867  25.420  1.00 15.89 ? 258 TYR B CD1 1 
ATOM   4271 C  CD2 . TYR B 1 258 ? -6.873  -3.014  23.881  1.00 13.81 ? 258 TYR B CD2 1 
ATOM   4272 C  CE1 . TYR B 1 258 ? -5.934  -4.124  26.299  1.00 16.85 ? 258 TYR B CE1 1 
ATOM   4273 C  CE2 . TYR B 1 258 ? -6.113  -2.223  24.774  1.00 17.65 ? 258 TYR B CE2 1 
ATOM   4274 C  CZ  . TYR B 1 258 ? -5.635  -2.812  25.961  1.00 18.14 ? 258 TYR B CZ  1 
ATOM   4275 O  OH  . TYR B 1 258 ? -4.878  -1.949  26.757  1.00 22.17 ? 258 TYR B OH  1 
ATOM   4276 N  N   . THR B 1 259 ? -7.950  -8.219  21.853  1.00 8.26  ? 259 THR B N   1 
ATOM   4277 C  CA  . THR B 1 259 ? -8.572  -9.134  20.957  1.00 7.52  ? 259 THR B CA  1 
ATOM   4278 C  C   . THR B 1 259 ? -9.864  -9.662  21.591  1.00 7.71  ? 259 THR B C   1 
ATOM   4279 O  O   . THR B 1 259 ? -9.918  -9.859  22.826  1.00 8.33  ? 259 THR B O   1 
ATOM   4280 C  CB  . THR B 1 259 ? -7.706  -10.348 20.570  1.00 8.33  ? 259 THR B CB  1 
ATOM   4281 O  OG1 . THR B 1 259 ? -7.263  -11.008 21.752  1.00 10.95 ? 259 THR B OG1 1 
ATOM   4282 C  CG2 . THR B 1 259 ? -6.427  -9.865  19.857  1.00 8.79  ? 259 THR B CG2 1 
ATOM   4283 N  N   . SER B 1 260 ? -10.850 -9.908  20.780  1.00 7.20  ? 260 SER B N   1 
ATOM   4284 C  CA  . SER B 1 260 ? -12.139 -10.476 21.275  1.00 8.46  ? 260 SER B CA  1 
ATOM   4285 C  C   . SER B 1 260 ? -12.084 -11.972 21.289  1.00 8.93  ? 260 SER B C   1 
ATOM   4286 O  O   . SER B 1 260 ? -13.076 -12.653 21.704  1.00 11.02 ? 260 SER B O   1 
ATOM   4287 C  CB  . SER B 1 260 ? -13.288 -10.035 20.372  1.00 8.14  ? 260 SER B CB  1 
ATOM   4288 O  OG  . SER B 1 260 ? -13.151 -10.636 19.097  1.00 8.59  ? 260 SER B OG  1 
ATOM   4289 N  N   . PHE B 1 261 ? -10.965 -12.566 20.874  1.00 8.83  ? 261 PHE B N   1 
ATOM   4290 C  CA  . PHE B 1 261 ? -10.731 -14.021 20.792  1.00 10.08 ? 261 PHE B CA  1 
ATOM   4291 C  C   . PHE B 1 261 ? -9.515  -14.334 21.625  1.00 10.39 ? 261 PHE B C   1 
ATOM   4292 O  O   . PHE B 1 261 ? -8.583  -13.600 21.728  1.00 10.23 ? 261 PHE B O   1 
ATOM   4293 C  CB  . PHE B 1 261 ? -10.629 -14.440 19.347  1.00 10.03 ? 261 PHE B CB  1 
ATOM   4294 C  CG  . PHE B 1 261 ? -9.593  -13.713 18.569  1.00 9.80  ? 261 PHE B CG  1 
ATOM   4295 C  CD1 . PHE B 1 261 ? -8.308  -14.255 18.450  1.00 11.85 ? 261 PHE B CD1 1 
ATOM   4296 C  CD2 . PHE B 1 261 ? -9.870  -12.493 17.940  1.00 10.16 ? 261 PHE B CD2 1 
ATOM   4297 C  CE1 . PHE B 1 261 ? -7.300  -13.580 17.806  1.00 12.20 ? 261 PHE B CE1 1 
ATOM   4298 C  CE2 . PHE B 1 261 ? -8.864  -11.875 17.226  1.00 11.69 ? 261 PHE B CE2 1 
ATOM   4299 C  CZ  . PHE B 1 261 ? -7.610  -12.381 17.166  1.00 12.16 ? 261 PHE B CZ  1 
ATOM   4300 N  N   . SER B 1 262 ? -9.576  -15.515 22.264  1.00 14.98 ? 262 SER B N   1 
ATOM   4301 C  CA  . SER B 1 262 ? -8.475  -15.746 23.184  1.00 18.71 ? 262 SER B CA  1 
ATOM   4302 C  C   . SER B 1 262 ? -7.382  -16.514 22.488  1.00 28.69 ? 262 SER B C   1 
ATOM   4303 O  O   . SER B 1 262 ? -6.198  -16.167 22.639  1.00 36.30 ? 262 SER B O   1 
ATOM   4304 C  CB  . SER B 1 262 ? -8.997  -16.440 24.475  1.00 24.49 ? 262 SER B CB  1 
ATOM   4305 O  OG  . SER B 1 262 ? -9.632  -17.653 24.105  1.00 32.65 ? 262 SER B OG  1 
ATOM   4306 N  N   . GLN B 1 263 ? -7.835  -17.481 21.685  1.00 31.82 ? 263 GLN B N   1 
ATOM   4307 C  CA  . GLN B 1 263 ? -7.013  -18.338 20.813  1.00 35.81 ? 263 GLN B CA  1 
ATOM   4308 C  C   . GLN B 1 263 ? -7.664  -18.445 19.414  1.00 32.94 ? 263 GLN B C   1 
ATOM   4309 O  O   . GLN B 1 263 ? -7.033  -18.962 18.441  1.00 33.98 ? 263 GLN B O   1 
ATOM   4310 C  CB  . GLN B 1 263 ? -6.822  -19.762 21.439  1.00 44.51 ? 263 GLN B CB  1 
ATOM   4311 C  CG  . GLN B 1 263 ? -8.113  -20.539 21.733  1.00 53.52 ? 263 GLN B CG  1 
ATOM   4312 C  CD  . GLN B 1 263 ? -7.939  -21.634 22.788  1.00 58.28 ? 263 GLN B CD  1 
ATOM   4313 O  OE1 . GLN B 1 263 ? -6.988  -22.411 22.743  1.00 68.15 ? 263 GLN B OE1 1 
ATOM   4314 N  NE2 . GLN B 1 263 ? -8.873  -21.707 23.732  1.00 56.38 ? 263 GLN B NE2 1 
ATOM   4315 O  OXT . GLN B 1 263 ? -8.837  -18.021 19.287  1.00 22.60 ? 263 GLN B OXT 1 
ATOM   4316 N  N   . LYS C 1 3   ? 34.334  18.698  -27.078 1.00 47.80 ? 3   LYS C N   1 
ATOM   4317 C  CA  . LYS C 1 3   ? 33.267  18.245  -26.117 1.00 45.15 ? 3   LYS C CA  1 
ATOM   4318 C  C   . LYS C 1 3   ? 32.222  17.365  -26.822 1.00 36.45 ? 3   LYS C C   1 
ATOM   4319 O  O   . LYS C 1 3   ? 31.507  17.838  -27.749 1.00 40.15 ? 3   LYS C O   1 
ATOM   4320 C  CB  . LYS C 1 3   ? 32.572  19.438  -25.436 1.00 53.64 ? 3   LYS C CB  1 
ATOM   4321 C  CG  . LYS C 1 3   ? 31.208  19.120  -24.821 1.00 50.01 ? 3   LYS C CG  1 
ATOM   4322 C  CD  . LYS C 1 3   ? 31.382  18.736  -23.373 1.00 52.72 ? 3   LYS C CD  1 
ATOM   4323 C  CE  . LYS C 1 3   ? 30.606  17.477  -23.039 1.00 59.41 ? 3   LYS C CE  1 
ATOM   4324 N  NZ  . LYS C 1 3   ? 31.283  16.802  -21.887 1.00 52.16 ? 3   LYS C NZ  1 
ATOM   4325 N  N   . TRP C 1 4   ? 32.164  16.112  -26.339 1.00 24.55 ? 4   TRP C N   1 
ATOM   4326 C  CA  . TRP C 1 4   ? 31.256  15.046  -26.787 1.00 17.87 ? 4   TRP C CA  1 
ATOM   4327 C  C   . TRP C 1 4   ? 31.168  13.901  -25.814 1.00 16.44 ? 4   TRP C C   1 
ATOM   4328 O  O   . TRP C 1 4   ? 32.100  13.598  -25.018 1.00 17.35 ? 4   TRP C O   1 
ATOM   4329 C  CB  . TRP C 1 4   ? 31.675  14.558  -28.173 1.00 14.52 ? 4   TRP C CB  1 
ATOM   4330 C  CG  . TRP C 1 4   ? 33.001  13.855  -28.216 1.00 12.62 ? 4   TRP C CG  1 
ATOM   4331 C  CD1 . TRP C 1 4   ? 34.257  14.412  -28.420 1.00 13.13 ? 4   TRP C CD1 1 
ATOM   4332 C  CD2 . TRP C 1 4   ? 33.236  12.420  -28.073 1.00 11.09 ? 4   TRP C CD2 1 
ATOM   4333 N  NE1 . TRP C 1 4   ? 35.225  13.445  -28.408 1.00 14.11 ? 4   TRP C NE1 1 
ATOM   4334 C  CE2 . TRP C 1 4   ? 34.680  12.229  -28.206 1.00 13.29 ? 4   TRP C CE2 1 
ATOM   4335 C  CE3 . TRP C 1 4   ? 32.426  11.325  -27.856 1.00 10.59 ? 4   TRP C CE3 1 
ATOM   4336 C  CZ2 . TRP C 1 4   ? 35.259  10.983  -28.122 1.00 12.22 ? 4   TRP C CZ2 1 
ATOM   4337 C  CZ3 . TRP C 1 4   ? 33.022  10.072  -27.772 1.00 9.36  ? 4   TRP C CZ3 1 
ATOM   4338 C  CH2 . TRP C 1 4   ? 34.407  9.906   -27.901 1.00 11.36 ? 4   TRP C CH2 1 
ATOM   4339 N  N   . THR C 1 5   ? 30.027  13.195  -25.843 1.00 14.58 ? 5   THR C N   1 
ATOM   4340 C  CA  . THR C 1 5   ? 29.864  12.059  -24.949 1.00 15.47 ? 5   THR C CA  1 
ATOM   4341 C  C   . THR C 1 5   ? 29.115  10.943  -25.726 1.00 14.05 ? 5   THR C C   1 
ATOM   4342 O  O   . THR C 1 5   ? 28.787  11.104  -26.947 1.00 15.19 ? 5   THR C O   1 
ATOM   4343 C  CB  . THR C 1 5   ? 28.902  12.375  -23.816 1.00 18.51 ? 5   THR C CB  1 
ATOM   4344 O  OG1 . THR C 1 5   ? 27.649  12.718  -24.424 1.00 19.36 ? 5   THR C OG1 1 
ATOM   4345 C  CG2 . THR C 1 5   ? 29.410  13.637  -23.076 1.00 18.97 ? 5   THR C CG2 1 
ATOM   4346 N  N   . TYR C 1 6   ? 28.875  9.801   -25.067 1.00 17.85 ? 6   TYR C N   1 
ATOM   4347 C  CA  . TYR C 1 6   ? 28.015  8.766   -25.632 1.00 18.64 ? 6   TYR C CA  1 
ATOM   4348 C  C   . TYR C 1 6   ? 26.539  8.790   -25.122 1.00 18.90 ? 6   TYR C C   1 
ATOM   4349 O  O   . TYR C 1 6   ? 25.776  7.837   -25.303 1.00 21.77 ? 6   TYR C O   1 
ATOM   4350 C  CB  . TYR C 1 6   ? 28.519  7.384   -25.467 1.00 15.90 ? 6   TYR C CB  1 
ATOM   4351 C  CG  . TYR C 1 6   ? 29.798  7.073   -26.168 1.00 15.26 ? 6   TYR C CG  1 
ATOM   4352 C  CD1 . TYR C 1 6   ? 31.023  7.201   -25.521 1.00 14.05 ? 6   TYR C CD1 1 
ATOM   4353 C  CD2 . TYR C 1 6   ? 29.782  6.599   -27.471 1.00 12.74 ? 6   TYR C CD2 1 
ATOM   4354 C  CE1 . TYR C 1 6   ? 32.196  6.875   -26.167 1.00 13.17 ? 6   TYR C CE1 1 
ATOM   4355 C  CE2 . TYR C 1 6   ? 30.948  6.277   -28.121 1.00 12.13 ? 6   TYR C CE2 1 
ATOM   4356 C  CZ  . TYR C 1 6   ? 32.148  6.417   -27.470 1.00 12.82 ? 6   TYR C CZ  1 
ATOM   4357 O  OH  . TYR C 1 6   ? 33.299  6.087   -28.142 1.00 14.42 ? 6   TYR C OH  1 
ATOM   4358 N  N   . PHE C 1 7   ? 26.117  9.825   -24.413 1.00 24.20 ? 7   PHE C N   1 
ATOM   4359 C  CA  . PHE C 1 7   ? 24.731  9.847   -23.931 1.00 34.17 ? 7   PHE C CA  1 
ATOM   4360 C  C   . PHE C 1 7   ? 24.152  11.261  -23.990 1.00 40.45 ? 7   PHE C C   1 
ATOM   4361 O  O   . PHE C 1 7   ? 24.729  12.144  -24.633 1.00 36.92 ? 7   PHE C O   1 
ATOM   4362 C  CB  . PHE C 1 7   ? 24.739  9.408   -22.480 1.00 40.46 ? 7   PHE C CB  1 
ATOM   4363 C  CG  . PHE C 1 7   ? 25.485  10.373  -21.618 1.00 44.98 ? 7   PHE C CG  1 
ATOM   4364 C  CD1 . PHE C 1 7   ? 24.847  11.526  -21.122 1.00 52.64 ? 7   PHE C CD1 1 
ATOM   4365 C  CD2 . PHE C 1 7   ? 26.834  10.197  -21.369 1.00 48.10 ? 7   PHE C CD2 1 
ATOM   4366 C  CE1 . PHE C 1 7   ? 25.541  12.461  -20.367 1.00 50.27 ? 7   PHE C CE1 1 
ATOM   4367 C  CE2 . PHE C 1 7   ? 27.530  11.126  -20.609 1.00 49.37 ? 7   PHE C CE2 1 
ATOM   4368 C  CZ  . PHE C 1 7   ? 26.889  12.258  -20.119 1.00 42.72 ? 7   PHE C CZ  1 
ATOM   4369 N  N   . GLY C 1 8   ? 23.029  11.479  -23.297 1.00 40.69 ? 8   GLY C N   1 
ATOM   4370 C  CA  . GLY C 1 8   ? 22.452  12.826  -23.039 1.00 37.00 ? 8   GLY C CA  1 
ATOM   4371 C  C   . GLY C 1 8   ? 22.412  13.620  -24.329 1.00 40.38 ? 8   GLY C C   1 
ATOM   4372 O  O   . GLY C 1 8   ? 22.300  13.001  -25.423 1.00 43.25 ? 8   GLY C O   1 
ATOM   4373 N  N   . PRO C 1 9   ? 22.545  14.963  -24.238 1.00 33.53 ? 9   PRO C N   1 
ATOM   4374 C  CA  . PRO C 1 9   ? 22.501  15.828  -25.434 1.00 28.34 ? 9   PRO C CA  1 
ATOM   4375 C  C   . PRO C 1 9   ? 23.813  16.038  -26.211 1.00 23.79 ? 9   PRO C C   1 
ATOM   4376 O  O   . PRO C 1 9   ? 23.799  16.702  -27.237 1.00 21.92 ? 9   PRO C O   1 
ATOM   4377 C  CB  . PRO C 1 9   ? 22.110  17.203  -24.846 1.00 36.14 ? 9   PRO C CB  1 
ATOM   4378 C  CG  . PRO C 1 9   ? 22.624  17.168  -23.453 1.00 30.20 ? 9   PRO C CG  1 
ATOM   4379 C  CD  . PRO C 1 9   ? 22.474  15.757  -22.976 1.00 35.61 ? 9   PRO C CD  1 
ATOM   4380 N  N   . ASP C 1 10  ? 24.945  15.601  -25.684 1.00 22.92 ? 10  ASP C N   1 
ATOM   4381 C  CA  . ASP C 1 10  ? 26.177  15.711  -26.459 1.00 20.89 ? 10  ASP C CA  1 
ATOM   4382 C  C   . ASP C 1 10  ? 26.622  14.371  -27.070 1.00 16.93 ? 10  ASP C C   1 
ATOM   4383 O  O   . ASP C 1 10  ? 27.793  14.251  -27.473 1.00 15.64 ? 10  ASP C O   1 
ATOM   4384 C  CB  . ASP C 1 10  ? 27.311  16.249  -25.573 1.00 24.42 ? 10  ASP C CB  1 
ATOM   4385 C  CG  . ASP C 1 10  ? 27.041  17.712  -25.109 1.00 33.67 ? 10  ASP C CG  1 
ATOM   4386 O  OD1 . ASP C 1 10  ? 26.594  18.537  -25.946 1.00 35.32 ? 10  ASP C OD1 1 
ATOM   4387 O  OD2 . ASP C 1 10  ? 27.262  18.003  -23.900 1.00 38.24 ? 10  ASP C OD2 1 
ATOM   4388 N  N   . GLY C 1 11  ? 25.658  13.431  -27.087 1.00 18.09 ? 11  GLY C N   1 
ATOM   4389 C  CA  . GLY C 1 11  ? 25.811  12.056  -27.612 1.00 13.58 ? 11  GLY C CA  1 
ATOM   4390 C  C   . GLY C 1 11  ? 25.886  12.014  -29.157 1.00 11.10 ? 11  GLY C C   1 
ATOM   4391 O  O   . GLY C 1 11  ? 25.929  12.985  -29.858 1.00 10.45 ? 11  GLY C O   1 
ATOM   4392 N  N   . GLU C 1 12  ? 25.937  10.785  -29.598 1.00 9.07  ? 12  GLU C N   1 
ATOM   4393 C  CA  . GLU C 1 12  ? 26.308  10.525  -30.970 1.00 7.86  ? 12  GLU C CA  1 
ATOM   4394 C  C   . GLU C 1 12  ? 25.473  11.159  -32.057 1.00 7.40  ? 12  GLU C C   1 
ATOM   4395 O  O   . GLU C 1 12  ? 26.024  11.521  -33.100 1.00 6.58  ? 12  GLU C O   1 
ATOM   4396 C  CB  . GLU C 1 12  ? 26.533  9.005   -31.212 1.00 7.76  ? 12  GLU C CB  1 
ATOM   4397 C  CG  . GLU C 1 12  ? 25.183  8.261   -31.335 1.00 8.56  ? 12  GLU C CG  1 
ATOM   4398 C  CD  . GLU C 1 12  ? 25.437  6.766   -31.126 1.00 8.54  ? 12  GLU C CD  1 
ATOM   4399 O  OE1 . GLU C 1 12  ? 25.698  6.048   -32.128 1.00 8.08  ? 12  GLU C OE1 1 
ATOM   4400 O  OE2 . GLU C 1 12  ? 25.440  6.336   -29.947 1.00 10.65 ? 12  GLU C OE2 1 
ATOM   4401 N  N   . ASN C 1 13  ? 24.174  11.341  -31.824 1.00 6.72  ? 13  ASN C N   1 
ATOM   4402 C  CA  . ASN C 1 13  ? 23.358  11.968  -32.849 1.00 6.56  ? 13  ASN C CA  1 
ATOM   4403 C  C   . ASN C 1 13  ? 23.681  13.464  -32.982 1.00 6.79  ? 13  ASN C C   1 
ATOM   4404 O  O   . ASN C 1 13  ? 23.300  14.026  -34.016 1.00 8.05  ? 13  ASN C O   1 
ATOM   4405 C  CB  . ASN C 1 13  ? 21.930  11.829  -32.507 1.00 6.52  ? 13  ASN C CB  1 
ATOM   4406 C  CG  . ASN C 1 13  ? 21.441  10.393  -32.658 1.00 6.42  ? 13  ASN C CG  1 
ATOM   4407 O  OD1 . ASN C 1 13  ? 22.118  9.485   -33.188 1.00 7.65  ? 13  ASN C OD1 1 
ATOM   4408 N  ND2 . ASN C 1 13  ? 20.249  10.211  -32.168 1.00 6.03  ? 13  ASN C ND2 1 
ATOM   4409 N  N   A SER C 1 14  ? 24.393  14.014  -31.984 0.50 6.88  ? 14  SER C N   1 
ATOM   4410 N  N   B SER C 1 14  ? 24.390  14.051  -32.008 0.50 6.83  ? 14  SER C N   1 
ATOM   4411 C  CA  A SER C 1 14  ? 24.783  15.428  -31.998 0.50 7.08  ? 14  SER C CA  1 
ATOM   4412 C  CA  B SER C 1 14  ? 24.757  15.477  -32.136 0.50 6.96  ? 14  SER C CA  1 
ATOM   4413 C  C   A SER C 1 14  ? 26.156  15.696  -32.543 0.50 7.14  ? 14  SER C C   1 
ATOM   4414 C  C   B SER C 1 14  ? 26.227  15.694  -32.358 0.50 7.08  ? 14  SER C C   1 
ATOM   4415 O  O   A SER C 1 14  ? 26.457  16.849  -32.934 0.50 6.01  ? 14  SER C O   1 
ATOM   4416 O  O   B SER C 1 14  ? 26.682  16.821  -32.383 0.50 6.40  ? 14  SER C O   1 
ATOM   4417 C  CB  A SER C 1 14  ? 24.631  16.000  -30.584 0.50 7.75  ? 14  SER C CB  1 
ATOM   4418 C  CB  B SER C 1 14  ? 24.454  16.178  -30.841 0.50 7.78  ? 14  SER C CB  1 
ATOM   4419 O  OG  A SER C 1 14  ? 23.235  16.150  -30.362 0.50 10.04 ? 14  SER C OG  1 
ATOM   4420 O  OG  B SER C 1 14  ? 25.351  15.668  -29.902 0.50 9.06  ? 14  SER C OG  1 
ATOM   4421 N  N   . TRP C 1 15  ? 26.985  14.668  -32.613 1.00 6.46  ? 15  TRP C N   1 
ATOM   4422 C  CA  . TRP C 1 15  ? 28.409  14.874  -32.943 1.00 6.55  ? 15  TRP C CA  1 
ATOM   4423 C  C   . TRP C 1 15  ? 28.587  15.696  -34.184 1.00 6.91  ? 15  TRP C C   1 
ATOM   4424 O  O   . TRP C 1 15  ? 29.548  16.489  -34.322 1.00 7.68  ? 15  TRP C O   1 
ATOM   4425 C  CB  . TRP C 1 15  ? 29.111  13.545  -33.153 1.00 6.20  ? 15  TRP C CB  1 
ATOM   4426 C  CG  . TRP C 1 15  ? 29.294  12.736  -31.916 1.00 6.22  ? 15  TRP C CG  1 
ATOM   4427 C  CD1 . TRP C 1 15  ? 29.015  13.077  -30.646 1.00 6.19  ? 15  TRP C CD1 1 
ATOM   4428 C  CD2 . TRP C 1 15  ? 29.705  11.374  -31.886 1.00 5.79  ? 15  TRP C CD2 1 
ATOM   4429 N  NE1 . TRP C 1 15  ? 29.288  12.032  -29.756 1.00 7.00  ? 15  TRP C NE1 1 
ATOM   4430 C  CE2 . TRP C 1 15  ? 29.744  10.947  -30.483 1.00 6.42  ? 15  TRP C CE2 1 
ATOM   4431 C  CE3 . TRP C 1 15  ? 30.058  10.472  -32.887 1.00 6.31  ? 15  TRP C CE3 1 
ATOM   4432 C  CZ2 . TRP C 1 15  ? 30.096  9.656   -30.096 1.00 6.32  ? 15  TRP C CZ2 1 
ATOM   4433 C  CZ3 . TRP C 1 15  ? 30.467  9.191   -32.474 1.00 6.04  ? 15  TRP C CZ3 1 
ATOM   4434 C  CH2 . TRP C 1 15  ? 30.519  8.802   -31.129 1.00 6.35  ? 15  TRP C CH2 1 
ATOM   4435 N  N   . SER C 1 16  ? 27.728  15.536  -35.185 1.00 6.42  ? 16  SER C N   1 
ATOM   4436 C  CA  . SER C 1 16  ? 27.898  16.122  -36.517 1.00 6.96  ? 16  SER C CA  1 
ATOM   4437 C  C   . SER C 1 16  ? 27.803  17.674  -36.425 1.00 7.72  ? 16  SER C C   1 
ATOM   4438 O  O   . SER C 1 16  ? 28.273  18.322  -37.399 1.00 7.60  ? 16  SER C O   1 
ATOM   4439 C  CB  . SER C 1 16  ? 26.860  15.624  -37.526 1.00 7.20  ? 16  SER C CB  1 
ATOM   4440 O  OG  . SER C 1 16  ? 25.565  15.990  -37.026 1.00 8.44  ? 16  SER C OG  1 
ATOM   4441 N  N   A LYS C 1 17  ? 27.270  18.207  -35.315 0.50 7.87  ? 17  LYS C N   1 
ATOM   4442 N  N   B LYS C 1 17  ? 27.262  18.260  -35.380 0.50 7.44  ? 17  LYS C N   1 
ATOM   4443 C  CA  A LYS C 1 17  ? 27.170  19.688  -35.144 0.50 8.33  ? 17  LYS C CA  1 
ATOM   4444 C  CA  B LYS C 1 17  ? 27.284  19.753  -35.398 0.50 7.31  ? 17  LYS C CA  1 
ATOM   4445 C  C   A LYS C 1 17  ? 28.559  20.289  -35.105 0.50 8.14  ? 17  LYS C C   1 
ATOM   4446 C  C   B LYS C 1 17  ? 28.771  20.248  -35.349 0.50 7.09  ? 17  LYS C C   1 
ATOM   4447 O  O   A LYS C 1 17  ? 28.785  21.314  -35.734 0.50 7.36  ? 17  LYS C O   1 
ATOM   4448 O  O   B LYS C 1 17  ? 29.206  21.085  -36.230 0.50 6.10  ? 17  LYS C O   1 
ATOM   4449 C  CB  A LYS C 1 17  ? 26.470  20.020  -33.870 0.50 9.26  ? 17  LYS C CB  1 
ATOM   4450 C  CB  B LYS C 1 17  ? 26.447  20.231  -34.249 0.50 7.59  ? 17  LYS C CB  1 
ATOM   4451 C  CG  A LYS C 1 17  ? 25.070  19.488  -33.749 0.50 11.27 ? 17  LYS C CG  1 
ATOM   4452 C  CG  B LYS C 1 17  ? 24.959  20.033  -34.405 0.50 9.52  ? 17  LYS C CG  1 
ATOM   4453 C  CD  A LYS C 1 17  ? 24.553  19.553  -32.339 0.50 13.04 ? 17  LYS C CD  1 
ATOM   4454 C  CD  B LYS C 1 17  ? 24.165  20.445  -33.183 0.50 10.98 ? 17  LYS C CD  1 
ATOM   4455 C  CE  A LYS C 1 17  ? 23.116  19.108  -32.342 0.50 14.56 ? 17  LYS C CE  1 
ATOM   4456 C  CE  B LYS C 1 17  ? 24.118  21.957  -33.070 0.50 10.37 ? 17  LYS C CE  1 
ATOM   4457 N  NZ  A LYS C 1 17  ? 22.402  19.500  -31.105 0.50 17.00 ? 17  LYS C NZ  1 
ATOM   4458 N  NZ  B LYS C 1 17  ? 23.282  22.276  -31.853 0.50 12.97 ? 17  LYS C NZ  1 
ATOM   4459 N  N   A LYS C 1 18  ? 29.463  19.678  -34.382 0.50 8.28  ? 18  LYS C N   1 
ATOM   4460 N  N   B LYS C 1 18  ? 29.499  19.758  -34.354 0.50 7.41  ? 18  LYS C N   1 
ATOM   4461 C  CA  A LYS C 1 18  ? 30.793  20.255  -34.319 0.50 9.05  ? 18  LYS C CA  1 
ATOM   4462 C  CA  B LYS C 1 18  ? 30.921  20.152  -34.174 0.50 8.23  ? 18  LYS C CA  1 
ATOM   4463 C  C   A LYS C 1 18  ? 31.727  19.529  -35.234 0.50 8.78  ? 18  LYS C C   1 
ATOM   4464 C  C   B LYS C 1 18  ? 31.953  19.343  -34.907 0.50 8.33  ? 18  LYS C C   1 
ATOM   4465 O  O   A LYS C 1 18  ? 32.666  20.120  -35.751 0.50 7.92  ? 18  LYS C O   1 
ATOM   4466 O  O   B LYS C 1 18  ? 33.167  19.711  -35.004 0.50 8.37  ? 18  LYS C O   1 
ATOM   4467 C  CB  A LYS C 1 18  ? 31.291  20.302  -32.876 0.50 10.90 ? 18  LYS C CB  1 
ATOM   4468 C  CB  B LYS C 1 18  ? 31.297  20.135  -32.716 0.50 9.63  ? 18  LYS C CB  1 
ATOM   4469 C  CG  A LYS C 1 18  ? 30.632  21.450  -32.115 0.50 13.63 ? 18  LYS C CG  1 
ATOM   4470 C  CG  B LYS C 1 18  ? 32.792  20.347  -32.581 0.50 11.69 ? 18  LYS C CG  1 
ATOM   4471 C  CD  A LYS C 1 18  ? 31.320  22.801  -32.250 0.50 16.75 ? 18  LYS C CD  1 
ATOM   4472 C  CD  B LYS C 1 18  ? 33.105  20.578  -31.113 0.50 14.91 ? 18  LYS C CD  1 
ATOM   4473 C  CE  A LYS C 1 18  ? 30.392  23.906  -31.771 0.50 19.31 ? 18  LYS C CE  1 
ATOM   4474 C  CE  B LYS C 1 18  ? 34.581  20.838  -30.875 0.50 16.35 ? 18  LYS C CE  1 
ATOM   4475 N  NZ  A LYS C 1 18  ? 28.988  23.635  -32.186 0.50 17.11 ? 18  LYS C NZ  1 
ATOM   4476 N  NZ  B LYS C 1 18  ? 34.756  21.966  -29.921 0.50 20.35 ? 18  LYS C NZ  1 
ATOM   4477 N  N   . TYR C 1 19  ? 31.502  18.223  -35.458 1.00 7.65  ? 19  TYR C N   1 
ATOM   4478 C  CA  . TYR C 1 19  ? 32.394  17.352  -36.214 1.00 7.48  ? 19  TYR C CA  1 
ATOM   4479 C  C   . TYR C 1 19  ? 31.711  16.901  -37.454 1.00 7.92  ? 19  TYR C C   1 
ATOM   4480 O  O   . TYR C 1 19  ? 31.023  15.804  -37.479 1.00 7.95  ? 19  TYR C O   1 
ATOM   4481 C  CB  . TYR C 1 19  ? 32.726  16.134  -35.303 1.00 7.99  ? 19  TYR C CB  1 
ATOM   4482 C  CG  . TYR C 1 19  ? 33.375  16.560  -34.006 1.00 9.37  ? 19  TYR C CG  1 
ATOM   4483 C  CD1 . TYR C 1 19  ? 34.734  16.869  -33.926 1.00 9.10  ? 19  TYR C CD1 1 
ATOM   4484 C  CD2 . TYR C 1 19  ? 32.623  16.555  -32.849 1.00 8.59  ? 19  TYR C CD2 1 
ATOM   4485 C  CE1 . TYR C 1 19  ? 35.304  17.217  -32.699 1.00 10.82 ? 19  TYR C CE1 1 
ATOM   4486 C  CE2 . TYR C 1 19  ? 33.218  16.861  -31.609 1.00 10.03 ? 19  TYR C CE2 1 
ATOM   4487 C  CZ  . TYR C 1 19  ? 34.498  17.228  -31.552 1.00 11.43 ? 19  TYR C CZ  1 
ATOM   4488 O  OH  . TYR C 1 19  ? 35.125  17.523  -30.304 1.00 16.59 ? 19  TYR C OH  1 
ATOM   4489 N  N   . PRO C 1 20  ? 31.744  17.646  -38.538 1.00 7.44  ? 20  PRO C N   1 
ATOM   4490 C  CA  . PRO C 1 20  ? 30.864  17.402  -39.650 1.00 8.40  ? 20  PRO C CA  1 
ATOM   4491 C  C   . PRO C 1 20  ? 31.108  16.008  -40.265 1.00 7.39  ? 20  PRO C C   1 
ATOM   4492 O  O   . PRO C 1 20  ? 30.202  15.520  -40.940 1.00 8.13  ? 20  PRO C O   1 
ATOM   4493 C  CB  . PRO C 1 20  ? 31.142  18.520  -40.663 1.00 9.40  ? 20  PRO C CB  1 
ATOM   4494 C  CG  . PRO C 1 20  ? 32.100  19.433  -39.928 1.00 13.66 ? 20  PRO C CG  1 
ATOM   4495 C  CD  . PRO C 1 20  ? 32.568  18.899  -38.651 1.00 9.16  ? 20  PRO C CD  1 
ATOM   4496 N  N   . SER C 1 21  ? 32.314  15.449  -40.170 1.00 7.45  ? 21  SER C N   1 
ATOM   4497 C  CA  . SER C 1 21  ? 32.498  14.138  -40.827 1.00 6.76  ? 21  SER C CA  1 
ATOM   4498 C  C   . SER C 1 21  ? 31.609  13.107  -40.169 1.00 7.21  ? 21  SER C C   1 
ATOM   4499 O  O   . SER C 1 21  ? 31.390  12.023  -40.811 1.00 6.16  ? 21  SER C O   1 
ATOM   4500 C  CB  . SER C 1 21  ? 33.957  13.697  -40.724 1.00 7.47  ? 21  SER C CB  1 
ATOM   4501 O  OG  . SER C 1 21  ? 34.734  14.539  -41.626 1.00 9.72  ? 21  SER C OG  1 
ATOM   4502 N  N   . CYS C 1 22  ? 31.097  13.363  -38.963 1.00 6.91  ? 22  CYS C N   1 
ATOM   4503 C  CA  . CYS C 1 22  ? 30.270  12.329  -38.324 1.00 7.01  ? 22  CYS C CA  1 
ATOM   4504 C  C   . CYS C 1 22  ? 28.956  12.161  -39.034 1.00 7.80  ? 22  CYS C C   1 
ATOM   4505 O  O   . CYS C 1 22  ? 28.259  11.139  -38.801 1.00 8.26  ? 22  CYS C O   1 
ATOM   4506 C  CB  . CYS C 1 22  ? 30.039  12.655  -36.838 1.00 6.52  ? 22  CYS C CB  1 
ATOM   4507 S  SG  . CYS C 1 22  ? 31.611  12.743  -35.876 1.00 7.96  ? 22  CYS C SG  1 
ATOM   4508 N  N   . GLY C 1 23  ? 28.595  13.096  -39.882 1.00 7.78  ? 23  GLY C N   1 
ATOM   4509 C  CA  . GLY C 1 23  ? 27.374  12.979  -40.692 1.00 8.06  ? 23  GLY C CA  1 
ATOM   4510 C  C   . GLY C 1 23  ? 27.713  12.752  -42.193 1.00 8.25  ? 23  GLY C C   1 
ATOM   4511 O  O   . GLY C 1 23  ? 26.834  12.842  -43.032 1.00 8.58  ? 23  GLY C O   1 
ATOM   4512 N  N   . GLY C 1 24  ? 28.969  12.444  -42.501 1.00 7.69  ? 24  GLY C N   1 
ATOM   4513 C  CA  . GLY C 1 24  ? 29.423  12.210  -43.847 1.00 8.26  ? 24  GLY C CA  1 
ATOM   4514 C  C   . GLY C 1 24  ? 29.469  10.787  -44.314 1.00 8.28  ? 24  GLY C C   1 
ATOM   4515 O  O   . GLY C 1 24  ? 28.795  9.925   -43.753 1.00 9.74  ? 24  GLY C O   1 
ATOM   4516 N  N   . LEU C 1 25  ? 30.305  10.542  -45.294 1.00 9.19  ? 25  LEU C N   1 
ATOM   4517 C  CA  . LEU C 1 25  ? 30.397  9.227   -45.924 1.00 9.62  ? 25  LEU C CA  1 
ATOM   4518 C  C   . LEU C 1 25  ? 31.317  8.323   -45.062 1.00 9.44  ? 25  LEU C C   1 
ATOM   4519 O  O   . LEU C 1 25  ? 32.110  8.728   -44.201 1.00 8.54  ? 25  LEU C O   1 
ATOM   4520 C  CB  . LEU C 1 25  ? 31.036  9.310   -47.320 1.00 13.18 ? 25  LEU C CB  1 
ATOM   4521 C  CG  . LEU C 1 25  ? 30.321  10.296  -48.272 1.00 15.79 ? 25  LEU C CG  1 
ATOM   4522 C  CD1 . LEU C 1 25  ? 31.104  10.330  -49.584 1.00 20.27 ? 25  LEU C CD1 1 
ATOM   4523 C  CD2 . LEU C 1 25  ? 28.890  9.861   -48.426 1.00 18.84 ? 25  LEU C CD2 1 
ATOM   4524 N  N   . LEU C 1 26  ? 31.200  7.047   -45.419 1.00 9.94  ? 26  LEU C N   1 
ATOM   4525 C  CA  . LEU C 1 26  ? 32.095  5.960   -44.940 1.00 8.94  ? 26  LEU C CA  1 
ATOM   4526 C  C   . LEU C 1 26  ? 32.118  5.783   -43.436 1.00 7.07  ? 26  LEU C C   1 
ATOM   4527 O  O   . LEU C 1 26  ? 33.154  5.428   -42.841 1.00 8.54  ? 26  LEU C O   1 
ATOM   4528 C  CB  . LEU C 1 26  ? 33.526  6.158   -45.495 1.00 11.03 ? 26  LEU C CB  1 
ATOM   4529 C  CG  . LEU C 1 26  ? 33.859  6.091   -46.996 1.00 16.53 ? 26  LEU C CG  1 
ATOM   4530 C  CD1 . LEU C 1 26  ? 35.363  5.987   -47.243 1.00 19.07 ? 26  LEU C CD1 1 
ATOM   4531 C  CD2 . LEU C 1 26  ? 33.119  5.016   -47.777 1.00 14.31 ? 26  LEU C CD2 1 
ATOM   4532 N  N   . GLN C 1 27  ? 31.021  6.004   -42.763 1.00 5.56  ? 27  GLN C N   1 
ATOM   4533 C  CA  . GLN C 1 27  ? 31.030  5.956   -41.310 1.00 5.55  ? 27  GLN C CA  1 
ATOM   4534 C  C   . GLN C 1 27  ? 31.049  4.506   -40.796 1.00 5.82  ? 27  GLN C C   1 
ATOM   4535 O  O   . GLN C 1 27  ? 30.371  3.556   -41.337 1.00 7.41  ? 27  GLN C O   1 
ATOM   4536 C  CB  . GLN C 1 27  ? 29.828  6.676   -40.748 1.00 5.14  ? 27  GLN C CB  1 
ATOM   4537 C  CG  . GLN C 1 27  ? 29.900  8.219   -41.071 1.00 5.02  ? 27  GLN C CG  1 
ATOM   4538 C  CD  . GLN C 1 27  ? 31.057  8.862   -40.346 1.00 4.68  ? 27  GLN C CD  1 
ATOM   4539 O  OE1 . GLN C 1 27  ? 31.035  9.038   -39.151 1.00 4.73  ? 27  GLN C OE1 1 
ATOM   4540 N  NE2 . GLN C 1 27  ? 32.181  9.118   -41.098 1.00 6.02  ? 27  GLN C NE2 1 
ATOM   4541 N  N   . SER C 1 28  ? 31.762  4.324   -39.724 1.00 4.95  ? 28  SER C N   1 
ATOM   4542 C  CA  . SER C 1 28  ? 31.865  3.077   -38.981 1.00 4.74  ? 28  SER C CA  1 
ATOM   4543 C  C   . SER C 1 28  ? 31.261  3.267   -37.590 1.00 4.81  ? 28  SER C C   1 
ATOM   4544 O  O   . SER C 1 28  ? 31.111  4.399   -37.112 1.00 5.58  ? 28  SER C O   1 
ATOM   4545 C  CB  . SER C 1 28  ? 33.371  2.735   -38.799 1.00 5.16  ? 28  SER C CB  1 
ATOM   4546 O  OG  . SER C 1 28  ? 33.925  2.464   -40.079 1.00 5.26  ? 28  SER C OG  1 
ATOM   4547 N  N   . PRO C 1 29  ? 30.885  2.209   -36.871 1.00 4.51  ? 29  PRO C N   1 
ATOM   4548 C  CA  . PRO C 1 29  ? 31.046  0.820   -37.231 1.00 4.28  ? 29  PRO C CA  1 
ATOM   4549 C  C   . PRO C 1 29  ? 29.824  0.370   -38.036 1.00 4.59  ? 29  PRO C C   1 
ATOM   4550 O  O   . PRO C 1 29  ? 28.894  1.120   -38.298 1.00 5.37  ? 29  PRO C O   1 
ATOM   4551 C  CB  . PRO C 1 29  ? 31.063  0.104   -35.872 1.00 4.81  ? 29  PRO C CB  1 
ATOM   4552 C  CG  . PRO C 1 29  ? 30.104  0.908   -35.059 1.00 5.89  ? 29  PRO C CG  1 
ATOM   4553 C  CD  . PRO C 1 29  ? 30.346  2.392   -35.525 1.00 5.20  ? 29  PRO C CD  1 
ATOM   4554 N  N   . ILE C 1 30  ? 29.857  -0.895  -38.450 1.00 5.19  ? 30  ILE C N   1 
ATOM   4555 C  CA  . ILE C 1 30  ? 28.830  -1.497  -39.315 1.00 5.55  ? 30  ILE C CA  1 
ATOM   4556 C  C   . ILE C 1 30  ? 28.581  -2.892  -38.853 1.00 5.60  ? 30  ILE C C   1 
ATOM   4557 O  O   . ILE C 1 30  ? 29.334  -3.519  -38.058 1.00 5.59  ? 30  ILE C O   1 
ATOM   4558 C  CB  . ILE C 1 30  ? 29.349  -1.470  -40.767 1.00 6.07  ? 30  ILE C CB  1 
ATOM   4559 C  CG1 . ILE C 1 30  ? 30.602  -2.407  -40.936 1.00 6.29  ? 30  ILE C CG1 1 
ATOM   4560 C  CG2 . ILE C 1 30  ? 29.497  -0.007  -41.229 1.00 7.26  ? 30  ILE C CG2 1 
ATOM   4561 C  CD1 . ILE C 1 30  ? 30.959  -2.592  -42.430 1.00 7.78  ? 30  ILE C CD1 1 
ATOM   4562 N  N   . ASP C 1 31  ? 27.423  -3.366  -39.332 1.00 7.10  ? 31  ASP C N   1 
ATOM   4563 C  CA  . ASP C 1 31  ? 27.078  -4.799  -39.177 1.00 7.11  ? 31  ASP C CA  1 
ATOM   4564 C  C   . ASP C 1 31  ? 27.694  -5.623  -40.280 1.00 7.84  ? 31  ASP C C   1 
ATOM   4565 O  O   . ASP C 1 31  ? 27.578  -5.337  -41.497 1.00 9.46  ? 31  ASP C O   1 
ATOM   4566 C  CB  . ASP C 1 31  ? 25.584  -4.958  -39.298 1.00 8.03  ? 31  ASP C CB  1 
ATOM   4567 C  CG  . ASP C 1 31  ? 25.145  -6.385  -39.044 1.00 9.51  ? 31  ASP C CG  1 
ATOM   4568 O  OD1 . ASP C 1 31  ? 25.619  -7.079  -38.088 1.00 9.25  ? 31  ASP C OD1 1 
ATOM   4569 O  OD2 . ASP C 1 31  ? 24.256  -6.814  -39.826 1.00 14.51 ? 31  ASP C OD2 1 
ATOM   4570 N  N   . LEU C 1 32  ? 28.369  -6.671  -39.854 1.00 7.68  ? 32  LEU C N   1 
ATOM   4571 C  CA  . LEU C 1 32  ? 29.023  -7.596  -40.779 1.00 8.57  ? 32  LEU C CA  1 
ATOM   4572 C  C   . LEU C 1 32  ? 28.118  -8.809  -40.967 1.00 9.50  ? 32  LEU C C   1 
ATOM   4573 O  O   . LEU C 1 32  ? 27.896  -9.582  -40.030 1.00 11.59 ? 32  LEU C O   1 
ATOM   4574 C  CB  . LEU C 1 32  ? 30.370  -8.011  -40.173 1.00 8.41  ? 32  LEU C CB  1 
ATOM   4575 C  CG  . LEU C 1 32  ? 31.287  -6.845  -39.726 1.00 9.54  ? 32  LEU C CG  1 
ATOM   4576 C  CD1 . LEU C 1 32  ? 32.516  -7.341  -38.977 1.00 10.39 ? 32  LEU C CD1 1 
ATOM   4577 C  CD2 . LEU C 1 32  ? 31.697  -6.128  -40.991 1.00 9.61  ? 32  LEU C CD2 1 
ATOM   4578 N  N   . HIS C 1 33  ? 27.628  -9.008  -42.162 1.00 12.62 ? 33  HIS C N   1 
ATOM   4579 C  CA  . HIS C 1 33  ? 26.668  -10.099 -42.340 1.00 14.02 ? 33  HIS C CA  1 
ATOM   4580 C  C   . HIS C 1 33  ? 26.859  -10.703 -43.696 1.00 13.35 ? 33  HIS C C   1 
ATOM   4581 O  O   . HIS C 1 33  ? 27.368  -10.037 -44.570 1.00 12.82 ? 33  HIS C O   1 
ATOM   4582 C  CB  . HIS C 1 33  ? 25.233  -9.679  -42.098 1.00 14.29 ? 33  HIS C CB  1 
ATOM   4583 C  CG  . HIS C 1 33  ? 24.778  -8.606  -42.992 1.00 15.05 ? 33  HIS C CG  1 
ATOM   4584 N  ND1 . HIS C 1 33  ? 24.013  -8.840  -44.092 1.00 18.77 ? 33  HIS C ND1 1 
ATOM   4585 C  CD2 . HIS C 1 33  ? 24.913  -7.222  -42.897 1.00 15.44 ? 33  HIS C CD2 1 
ATOM   4586 C  CE1 . HIS C 1 33  ? 23.761  -7.718  -44.690 1.00 17.37 ? 33  HIS C CE1 1 
ATOM   4587 N  NE2 . HIS C 1 33  ? 24.276  -6.702  -43.967 1.00 19.06 ? 33  HIS C NE2 1 
ATOM   4588 N  N   . SER C 1 34  ? 26.324  -11.915 -43.939 1.00 16.50 ? 34  SER C N   1 
ATOM   4589 C  CA  . SER C 1 34  ? 26.867  -12.750 -45.044 1.00 17.66 ? 34  SER C CA  1 
ATOM   4590 C  C   . SER C 1 34  ? 26.619  -12.203 -46.410 1.00 17.54 ? 34  SER C C   1 
ATOM   4591 O  O   . SER C 1 34  ? 27.462  -12.324 -47.301 1.00 17.07 ? 34  SER C O   1 
ATOM   4592 C  CB  . SER C 1 34  ? 26.277  -14.169 -45.010 1.00 23.38 ? 34  SER C CB  1 
ATOM   4593 O  OG  . SER C 1 34  ? 26.513  -14.712 -43.712 1.00 29.29 ? 34  SER C OG  1 
ATOM   4594 N  N   . ASP C 1 35  ? 25.492  -11.516 -46.543 1.00 18.32 ? 35  ASP C N   1 
ATOM   4595 C  CA  . ASP C 1 35  ? 25.016  -10.991 -47.862 1.00 21.93 ? 35  ASP C CA  1 
ATOM   4596 C  C   . ASP C 1 35  ? 25.862  -9.843  -48.430 1.00 18.04 ? 35  ASP C C   1 
ATOM   4597 O  O   . ASP C 1 35  ? 25.807  -9.473  -49.638 1.00 20.78 ? 35  ASP C O   1 
ATOM   4598 C  CB  . ASP C 1 35  ? 23.519  -10.609 -47.658 1.00 32.67 ? 35  ASP C CB  1 
ATOM   4599 C  CG  . ASP C 1 35  ? 22.849  -10.046 -48.870 1.00 45.50 ? 35  ASP C CG  1 
ATOM   4600 O  OD1 . ASP C 1 35  ? 23.318  -10.265 -50.019 1.00 57.61 ? 35  ASP C OD1 1 
ATOM   4601 O  OD2 . ASP C 1 35  ? 21.798  -9.393  -48.665 1.00 52.23 ? 35  ASP C OD2 1 
ATOM   4602 N  N   . ILE C 1 36  ? 26.720  -9.265  -47.589 1.00 13.49 ? 36  ILE C N   1 
ATOM   4603 C  CA  . ILE C 1 36  ? 27.577  -8.232  -48.079 1.00 13.93 ? 36  ILE C CA  1 
ATOM   4604 C  C   . ILE C 1 36  ? 29.038  -8.605  -48.018 1.00 13.31 ? 36  ILE C C   1 
ATOM   4605 O  O   . ILE C 1 36  ? 29.877  -7.790  -48.215 1.00 13.37 ? 36  ILE C O   1 
ATOM   4606 C  CB  . ILE C 1 36  ? 27.414  -6.930  -47.298 1.00 12.88 ? 36  ILE C CB  1 
ATOM   4607 C  CG1 . ILE C 1 36  ? 27.653  -7.123  -45.769 1.00 13.35 ? 36  ILE C CG1 1 
ATOM   4608 C  CG2 . ILE C 1 36  ? 26.023  -6.298  -47.591 1.00 16.62 ? 36  ILE C CG2 1 
ATOM   4609 C  CD1 . ILE C 1 36  ? 27.840  -5.791  -45.021 1.00 16.33 ? 36  ILE C CD1 1 
ATOM   4610 N  N   . LEU C 1 37  ? 29.339  -9.840  -47.746 1.00 14.53 ? 37  LEU C N   1 
ATOM   4611 C  CA  . LEU C 1 37  ? 30.720  -10.281 -47.728 1.00 12.44 ? 37  LEU C CA  1 
ATOM   4612 C  C   . LEU C 1 37  ? 31.183  -10.789 -49.042 1.00 14.12 ? 37  LEU C C   1 
ATOM   4613 O  O   . LEU C 1 37  ? 30.422  -11.467 -49.824 1.00 14.57 ? 37  LEU C O   1 
ATOM   4614 C  CB  . LEU C 1 37  ? 30.850  -11.441 -46.698 1.00 13.72 ? 37  LEU C CB  1 
ATOM   4615 C  CG  . LEU C 1 37  ? 30.349  -11.160 -45.309 1.00 12.58 ? 37  LEU C CG  1 
ATOM   4616 C  CD1 . LEU C 1 37  ? 30.678  -12.416 -44.491 1.00 14.47 ? 37  LEU C CD1 1 
ATOM   4617 C  CD2 . LEU C 1 37  ? 31.131  -9.936  -44.758 1.00 13.54 ? 37  LEU C CD2 1 
ATOM   4618 N  N   . GLN C 1 38  ? 32.427  -10.517 -49.380 1.00 11.90 ? 38  GLN C N   1 
ATOM   4619 C  CA  . GLN C 1 38  ? 33.004  -11.044 -50.623 1.00 12.36 ? 38  GLN C CA  1 
ATOM   4620 C  C   . GLN C 1 38  ? 34.459  -11.489 -50.322 1.00 10.07 ? 38  GLN C C   1 
ATOM   4621 O  O   . GLN C 1 38  ? 35.256  -10.679 -49.886 1.00 9.85  ? 38  GLN C O   1 
ATOM   4622 C  CB  . GLN C 1 38  ? 32.966  -9.983  -51.700 1.00 13.19 ? 38  GLN C CB  1 
ATOM   4623 C  CG  . GLN C 1 38  ? 33.338  -10.569 -53.077 1.00 15.74 ? 38  GLN C CG  1 
ATOM   4624 C  CD  . GLN C 1 38  ? 33.041  -9.603  -54.191 1.00 21.17 ? 38  GLN C CD  1 
ATOM   4625 O  OE1 . GLN C 1 38  ? 31.848  -9.454  -54.630 1.00 25.46 ? 38  GLN C OE1 1 
ATOM   4626 N  NE2 . GLN C 1 38  ? 34.035  -8.898  -54.584 1.00 21.34 ? 38  GLN C NE2 1 
ATOM   4627 N  N   . TYR C 1 39  ? 34.824  -12.746 -50.626 1.00 10.88 ? 39  TYR C N   1 
ATOM   4628 C  CA  . TYR C 1 39  ? 36.243  -13.119 -50.582 1.00 9.97  ? 39  TYR C CA  1 
ATOM   4629 C  C   . TYR C 1 39  ? 37.130  -12.296 -51.485 1.00 10.79 ? 39  TYR C C   1 
ATOM   4630 O  O   . TYR C 1 39  ? 36.749  -12.011 -52.639 1.00 13.07 ? 39  TYR C O   1 
ATOM   4631 C  CB  . TYR C 1 39  ? 36.333  -14.643 -50.946 1.00 14.07 ? 39  TYR C CB  1 
ATOM   4632 C  CG  . TYR C 1 39  ? 37.741  -15.098 -51.100 1.00 13.34 ? 39  TYR C CG  1 
ATOM   4633 C  CD1 . TYR C 1 39  ? 38.533  -15.259 -49.991 1.00 16.33 ? 39  TYR C CD1 1 
ATOM   4634 C  CD2 . TYR C 1 39  ? 38.284  -15.408 -52.379 1.00 17.16 ? 39  TYR C CD2 1 
ATOM   4635 C  CE1 . TYR C 1 39  ? 39.866  -15.650 -50.115 1.00 17.84 ? 39  TYR C CE1 1 
ATOM   4636 C  CE2 . TYR C 1 39  ? 39.629  -15.817 -52.510 1.00 18.88 ? 39  TYR C CE2 1 
ATOM   4637 C  CZ  . TYR C 1 39  ? 40.384  -15.972 -51.361 1.00 20.70 ? 39  TYR C CZ  1 
ATOM   4638 O  OH  . TYR C 1 39  ? 41.736  -16.369 -51.423 1.00 22.35 ? 39  TYR C OH  1 
ATOM   4639 N  N   . ASP C 1 40  ? 38.300  -11.875 -51.025 1.00 11.46 ? 40  ASP C N   1 
ATOM   4640 C  CA  . ASP C 1 40  ? 39.262  -11.074 -51.787 1.00 11.58 ? 40  ASP C CA  1 
ATOM   4641 C  C   . ASP C 1 40  ? 40.604  -11.751 -51.544 1.00 13.37 ? 40  ASP C C   1 
ATOM   4642 O  O   . ASP C 1 40  ? 41.121  -11.838 -50.408 1.00 12.46 ? 40  ASP C O   1 
ATOM   4643 C  CB  . ASP C 1 40  ? 39.223  -9.671  -51.252 1.00 12.10 ? 40  ASP C CB  1 
ATOM   4644 C  CG  . ASP C 1 40  ? 40.202  -8.746  -51.946 1.00 17.02 ? 40  ASP C CG  1 
ATOM   4645 O  OD1 . ASP C 1 40  ? 41.076  -9.241  -52.688 1.00 15.28 ? 40  ASP C OD1 1 
ATOM   4646 O  OD2 . ASP C 1 40  ? 40.107  -7.521  -51.728 1.00 20.21 ? 40  ASP C OD2 1 
ATOM   4647 N  N   . ALA C 1 41  ? 41.163  -12.239 -52.669 1.00 13.88 ? 41  ALA C N   1 
ATOM   4648 C  CA  . ALA C 1 41  ? 42.478  -12.870 -52.609 1.00 14.85 ? 41  ALA C CA  1 
ATOM   4649 C  C   . ALA C 1 41  ? 43.621  -11.985 -52.242 1.00 14.65 ? 41  ALA C C   1 
ATOM   4650 O  O   . ALA C 1 41  ? 44.700  -12.503 -51.837 1.00 14.40 ? 41  ALA C O   1 
ATOM   4651 C  CB  . ALA C 1 41  ? 42.724  -13.543 -53.951 1.00 16.70 ? 41  ALA C CB  1 
ATOM   4652 N  N   . SER C 1 42  ? 43.465  -10.658 -52.328 1.00 13.28 ? 42  SER C N   1 
ATOM   4653 C  CA  . SER C 1 42  ? 44.549  -9.764  -51.963 1.00 14.83 ? 42  SER C CA  1 
ATOM   4654 C  C   . SER C 1 42  ? 44.781  -9.739  -50.402 1.00 12.56 ? 42  SER C C   1 
ATOM   4655 O  O   . SER C 1 42  ? 45.764  -9.147  -49.907 1.00 16.92 ? 42  SER C O   1 
ATOM   4656 C  CB  . SER C 1 42  ? 44.274  -8.406  -52.499 1.00 16.03 ? 42  SER C CB  1 
ATOM   4657 O  OG  . SER C 1 42  ? 43.255  -7.780  -51.689 1.00 18.75 ? 42  SER C OG  1 
ATOM   4658 N  N   . LEU C 1 43  ? 43.804  -10.302 -49.649 1.00 13.04 ? 43  LEU C N   1 
ATOM   4659 C  CA  . LEU C 1 43  ? 43.846  -10.096 -48.184 1.00 11.66 ? 43  LEU C CA  1 
ATOM   4660 C  C   . LEU C 1 43  ? 44.674  -11.192 -47.537 1.00 13.28 ? 43  LEU C C   1 
ATOM   4661 O  O   . LEU C 1 43  ? 44.174  -12.156 -46.925 1.00 13.28 ? 43  LEU C O   1 
ATOM   4662 C  CB  . LEU C 1 43  ? 42.415  -10.112 -47.658 1.00 10.70 ? 43  LEU C CB  1 
ATOM   4663 C  CG  . LEU C 1 43  ? 41.550  -8.996  -48.181 1.00 11.55 ? 43  LEU C CG  1 
ATOM   4664 C  CD1 . LEU C 1 43  ? 40.194  -9.079  -47.494 1.00 11.59 ? 43  LEU C CD1 1 
ATOM   4665 C  CD2 . LEU C 1 43  ? 42.175  -7.671  -47.977 1.00 11.38 ? 43  LEU C CD2 1 
ATOM   4666 N  N   . THR C 1 44  ? 45.962  -11.050 -47.740 1.00 14.28 ? 44  THR C N   1 
ATOM   4667 C  CA  . THR C 1 44  ? 46.909  -12.032 -47.204 1.00 14.76 ? 44  THR C CA  1 
ATOM   4668 C  C   . THR C 1 44  ? 47.141  -11.744 -45.728 1.00 15.29 ? 44  THR C C   1 
ATOM   4669 O  O   . THR C 1 44  ? 46.682  -10.720 -45.190 1.00 14.18 ? 44  THR C O   1 
ATOM   4670 C  CB  . THR C 1 44  ? 48.242  -11.871 -48.011 1.00 17.12 ? 44  THR C CB  1 
ATOM   4671 O  OG1 . THR C 1 44  ? 48.554  -10.464 -48.129 1.00 17.92 ? 44  THR C OG1 1 
ATOM   4672 C  CG2 . THR C 1 44  ? 48.057  -12.477 -49.319 1.00 19.73 ? 44  THR C CG2 1 
ATOM   4673 N  N   . PRO C 1 45  ? 47.849  -12.588 -44.987 1.00 15.63 ? 45  PRO C N   1 
ATOM   4674 C  CA  . PRO C 1 45  ? 48.083  -12.376 -43.579 1.00 16.65 ? 45  PRO C CA  1 
ATOM   4675 C  C   . PRO C 1 45  ? 48.870  -11.140 -43.254 1.00 16.01 ? 45  PRO C C   1 
ATOM   4676 O  O   . PRO C 1 45  ? 49.883  -10.883 -43.902 1.00 18.14 ? 45  PRO C O   1 
ATOM   4677 C  CB  . PRO C 1 45  ? 48.867  -13.610 -43.164 1.00 18.41 ? 45  PRO C CB  1 
ATOM   4678 C  CG  . PRO C 1 45  ? 48.385  -14.673 -44.128 1.00 17.16 ? 45  PRO C CG  1 
ATOM   4679 C  CD  . PRO C 1 45  ? 48.316  -13.942 -45.417 1.00 16.87 ? 45  PRO C CD  1 
ATOM   4680 N  N   . LEU C 1 46  ? 48.428  -10.361 -42.290 1.00 14.67 ? 46  LEU C N   1 
ATOM   4681 C  CA  . LEU C 1 46  ? 49.207  -9.291  -41.751 1.00 17.02 ? 46  LEU C CA  1 
ATOM   4682 C  C   . LEU C 1 46  ? 50.348  -9.842  -40.859 1.00 15.62 ? 46  LEU C C   1 
ATOM   4683 O  O   . LEU C 1 46  ? 50.173  -10.863 -40.226 1.00 16.92 ? 46  LEU C O   1 
ATOM   4684 C  CB  . LEU C 1 46  ? 48.343  -8.357  -40.925 1.00 17.01 ? 46  LEU C CB  1 
ATOM   4685 C  CG  . LEU C 1 46  ? 47.271  -7.665  -41.753 1.00 18.58 ? 46  LEU C CG  1 
ATOM   4686 C  CD1 . LEU C 1 46  ? 46.466  -6.792  -40.818 1.00 20.68 ? 46  LEU C CD1 1 
ATOM   4687 C  CD2 . LEU C 1 46  ? 47.829  -6.971  -43.006 1.00 21.60 ? 46  LEU C CD2 1 
ATOM   4688 N  N   . GLU C 1 47  ? 51.402  -9.030  -40.768 1.00 16.47 ? 47  GLU C N   1 
ATOM   4689 C  CA  . GLU C 1 47  ? 52.501  -9.335  -39.828 1.00 18.62 ? 47  GLU C CA  1 
ATOM   4690 C  C   . GLU C 1 47  ? 52.568  -8.240  -38.811 1.00 18.01 ? 47  GLU C C   1 
ATOM   4691 O  O   . GLU C 1 47  ? 52.551  -7.057  -39.177 1.00 16.78 ? 47  GLU C O   1 
ATOM   4692 C  CB  . GLU C 1 47  ? 53.830  -9.386  -40.611 1.00 24.02 ? 47  GLU C CB  1 
ATOM   4693 C  CG  . GLU C 1 47  ? 53.861  -10.551 -41.621 1.00 32.27 ? 47  GLU C CG  1 
ATOM   4694 C  CD  . GLU C 1 47  ? 55.099  -10.585 -42.576 1.00 48.54 ? 47  GLU C CD  1 
ATOM   4695 O  OE1 . GLU C 1 47  ? 56.262  -10.613 -42.075 1.00 54.47 ? 47  GLU C OE1 1 
ATOM   4696 O  OE2 . GLU C 1 47  ? 54.924  -10.634 -43.841 1.00 47.48 ? 47  GLU C OE2 1 
ATOM   4697 N  N   . PHE C 1 48  ? 52.701  -8.595  -37.543 1.00 15.38 ? 48  PHE C N   1 
ATOM   4698 C  CA  . PHE C 1 48  ? 52.662  -7.665  -36.472 1.00 16.09 ? 48  PHE C CA  1 
ATOM   4699 C  C   . PHE C 1 48  ? 54.086  -7.572  -35.970 1.00 18.36 ? 48  PHE C C   1 
ATOM   4700 O  O   . PHE C 1 48  ? 54.666  -8.563  -35.422 1.00 22.13 ? 48  PHE C O   1 
ATOM   4701 C  CB  . PHE C 1 48  ? 51.641  -8.090  -35.391 1.00 18.66 ? 48  PHE C CB  1 
ATOM   4702 C  CG  . PHE C 1 48  ? 50.342  -8.507  -35.992 1.00 16.54 ? 48  PHE C CG  1 
ATOM   4703 C  CD1 . PHE C 1 48  ? 49.472  -7.556  -36.473 1.00 18.13 ? 48  PHE C CD1 1 
ATOM   4704 C  CD2 . PHE C 1 48  ? 50.039  -9.835  -36.134 1.00 16.46 ? 48  PHE C CD2 1 
ATOM   4705 C  CE1 . PHE C 1 48  ? 48.300  -7.945  -37.112 1.00 15.94 ? 48  PHE C CE1 1 
ATOM   4706 C  CE2 . PHE C 1 48  ? 48.880  -10.239 -36.747 1.00 17.54 ? 48  PHE C CE2 1 
ATOM   4707 C  CZ  . PHE C 1 48  ? 47.982  -9.249  -37.203 1.00 16.79 ? 48  PHE C CZ  1 
ATOM   4708 N  N   . GLN C 1 49  ? 54.674  -6.441  -36.207 1.00 14.90 ? 49  GLN C N   1 
ATOM   4709 C  CA  . GLN C 1 49  ? 56.133  -6.270  -35.941 1.00 17.49 ? 49  GLN C CA  1 
ATOM   4710 C  C   . GLN C 1 49  ? 56.329  -5.372  -34.783 1.00 17.15 ? 49  GLN C C   1 
ATOM   4711 O  O   . GLN C 1 49  ? 55.692  -4.317  -34.676 1.00 15.12 ? 49  GLN C O   1 
ATOM   4712 C  CB  . GLN C 1 49  ? 56.838  -5.674  -37.182 1.00 22.13 ? 49  GLN C CB  1 
ATOM   4713 C  CG  . GLN C 1 49  ? 56.586  -6.572  -38.378 1.00 26.10 ? 49  GLN C CG  1 
ATOM   4714 C  CD  . GLN C 1 49  ? 57.666  -6.606  -39.453 1.00 41.80 ? 49  GLN C CD  1 
ATOM   4715 O  OE1 . GLN C 1 49  ? 58.322  -5.584  -39.747 1.00 47.32 ? 49  GLN C OE1 1 
ATOM   4716 N  NE2 . GLN C 1 49  ? 57.845  -7.808  -40.080 1.00 39.20 ? 49  GLN C NE2 1 
ATOM   4717 N  N   . GLY C 1 50  ? 57.256  -5.759  -33.870 1.00 16.01 ? 50  GLY C N   1 
ATOM   4718 C  CA  . GLY C 1 50  ? 57.542  -4.922  -32.736 1.00 16.28 ? 50  GLY C CA  1 
ATOM   4719 C  C   . GLY C 1 50  ? 56.451  -4.884  -31.676 1.00 14.33 ? 50  GLY C C   1 
ATOM   4720 O  O   . GLY C 1 50  ? 56.465  -3.986  -30.828 1.00 16.20 ? 50  GLY C O   1 
ATOM   4721 N  N   . TYR C 1 51  ? 55.545  -5.846  -31.723 1.00 16.79 ? 51  TYR C N   1 
ATOM   4722 C  CA  . TYR C 1 51  ? 54.433  -5.938  -30.733 1.00 15.31 ? 51  TYR C CA  1 
ATOM   4723 C  C   . TYR C 1 51  ? 54.884  -6.455  -29.330 1.00 15.05 ? 51  TYR C C   1 
ATOM   4724 O  O   . TYR C 1 51  ? 54.175  -6.294  -28.344 1.00 14.97 ? 51  TYR C O   1 
ATOM   4725 C  CB  . TYR C 1 51  ? 53.305  -6.806  -31.289 1.00 14.71 ? 51  TYR C CB  1 
ATOM   4726 C  CG  . TYR C 1 51  ? 52.284  -6.081  -32.150 1.00 14.63 ? 51  TYR C CG  1 
ATOM   4727 C  CD1 . TYR C 1 51  ? 50.920  -6.302  -31.980 1.00 15.34 ? 51  TYR C CD1 1 
ATOM   4728 C  CD2 . TYR C 1 51  ? 52.681  -5.193  -33.142 1.00 14.12 ? 51  TYR C CD2 1 
ATOM   4729 C  CE1 . TYR C 1 51  ? 49.984  -5.652  -32.764 1.00 15.10 ? 51  TYR C CE1 1 
ATOM   4730 C  CE2 . TYR C 1 51  ? 51.750  -4.538  -33.931 1.00 14.74 ? 51  TYR C CE2 1 
ATOM   4731 C  CZ  . TYR C 1 51  ? 50.404  -4.772  -33.739 1.00 16.72 ? 51  TYR C CZ  1 
ATOM   4732 O  OH  . TYR C 1 51  ? 49.473  -4.125  -34.520 1.00 15.91 ? 51  TYR C OH  1 
ATOM   4733 N  N   . ASN C 1 52  ? 56.061  -7.071  -29.287 1.00 15.71 ? 52  ASN C N   1 
ATOM   4734 C  CA  . ASN C 1 52  ? 56.518  -7.660  -28.013 1.00 19.20 ? 52  ASN C CA  1 
ATOM   4735 C  C   . ASN C 1 52  ? 57.200  -6.577  -27.175 1.00 18.10 ? 52  ASN C C   1 
ATOM   4736 O  O   . ASN C 1 52  ? 58.403  -6.398  -27.268 1.00 22.26 ? 52  ASN C O   1 
ATOM   4737 C  CB  . ASN C 1 52  ? 57.449  -8.835  -28.345 1.00 20.03 ? 52  ASN C CB  1 
ATOM   4738 C  CG  . ASN C 1 52  ? 57.432  -9.837  -27.246 1.00 24.72 ? 52  ASN C CG  1 
ATOM   4739 O  OD1 . ASN C 1 52  ? 57.069  -9.471  -26.104 1.00 20.95 ? 52  ASN C OD1 1 
ATOM   4740 N  ND2 . ASN C 1 52  ? 57.625  -11.115 -27.580 1.00 33.73 ? 52  ASN C ND2 1 
ATOM   4741 N  N   . LEU C 1 53  ? 56.453  -5.831  -26.377 1.00 18.67 ? 53  LEU C N   1 
ATOM   4742 C  CA  . LEU C 1 53  ? 57.032  -4.699  -25.716 1.00 19.80 ? 53  LEU C CA  1 
ATOM   4743 C  C   . LEU C 1 53  ? 57.666  -5.262  -24.427 1.00 20.71 ? 53  LEU C C   1 
ATOM   4744 O  O   . LEU C 1 53  ? 57.067  -6.094  -23.700 1.00 21.90 ? 53  LEU C O   1 
ATOM   4745 C  CB  . LEU C 1 53  ? 55.936  -3.683  -25.458 1.00 17.72 ? 53  LEU C CB  1 
ATOM   4746 C  CG  . LEU C 1 53  ? 55.112  -3.195  -26.666 1.00 17.93 ? 53  LEU C CG  1 
ATOM   4747 C  CD1 . LEU C 1 53  ? 54.090  -2.243  -26.120 1.00 19.70 ? 53  LEU C CD1 1 
ATOM   4748 C  CD2 . LEU C 1 53  ? 56.052  -2.528  -27.676 1.00 20.46 ? 53  LEU C CD2 1 
ATOM   4749 N  N   . SER C 1 54  ? 58.851  -4.758  -24.123 1.00 21.28 ? 54  SER C N   1 
ATOM   4750 C  CA  . SER C 1 54  ? 59.574  -5.248  -22.932 1.00 24.52 ? 54  SER C CA  1 
ATOM   4751 C  C   . SER C 1 54  ? 58.838  -4.893  -21.649 1.00 25.31 ? 54  SER C C   1 
ATOM   4752 O  O   . SER C 1 54  ? 58.324  -3.764  -21.517 1.00 20.64 ? 54  SER C O   1 
ATOM   4753 C  CB  . SER C 1 54  ? 60.921  -4.554  -22.912 1.00 25.48 ? 54  SER C CB  1 
ATOM   4754 O  OG  . SER C 1 54  ? 61.644  -4.945  -21.737 1.00 31.14 ? 54  SER C OG  1 
ATOM   4755 N  N   . ALA C 1 55  ? 58.839  -5.827  -20.697 1.00 25.09 ? 55  ALA C N   1 
ATOM   4756 C  CA  . ALA C 1 55  ? 58.345  -5.543  -19.325 1.00 25.05 ? 55  ALA C CA  1 
ATOM   4757 C  C   . ALA C 1 55  ? 59.104  -4.445  -18.576 1.00 24.87 ? 55  ALA C C   1 
ATOM   4758 O  O   . ALA C 1 55  ? 58.572  -3.910  -17.574 1.00 25.13 ? 55  ALA C O   1 
ATOM   4759 C  CB  . ALA C 1 55  ? 58.284  -6.825  -18.494 1.00 23.61 ? 55  ALA C CB  1 
ATOM   4760 N  N   . ASN C 1 56  ? 60.300  -4.114  -19.072 1.00 23.63 ? 56  ASN C N   1 
ATOM   4761 C  CA  . ASN C 1 56  ? 61.189  -3.108  -18.474 1.00 26.53 ? 56  ASN C CA  1 
ATOM   4762 C  C   . ASN C 1 56  ? 60.752  -1.723  -18.887 1.00 27.71 ? 56  ASN C C   1 
ATOM   4763 O  O   . ASN C 1 56  ? 61.222  -0.729  -18.278 1.00 27.43 ? 56  ASN C O   1 
ATOM   4764 C  CB  . ASN C 1 56  ? 62.639  -3.236  -19.019 1.00 33.22 ? 56  ASN C CB  1 
ATOM   4765 C  CG  . ASN C 1 56  ? 63.370  -4.502  -18.580 1.00 42.29 ? 56  ASN C CG  1 
ATOM   4766 O  OD1 . ASN C 1 56  ? 62.827  -5.425  -17.925 1.00 45.49 ? 56  ASN C OD1 1 
ATOM   4767 N  ND2 . ASN C 1 56  ? 64.635  -4.565  -18.982 1.00 40.49 ? 56  ASN C ND2 1 
ATOM   4768 N  N   . LYS C 1 57  ? 59.922  -1.652  -19.959 1.00 21.80 ? 57  LYS C N   1 
ATOM   4769 C  CA  . LYS C 1 57  ? 59.441  -0.365  -20.501 1.00 22.47 ? 57  LYS C CA  1 
ATOM   4770 C  C   . LYS C 1 57  ? 58.069  -0.169  -20.028 1.00 19.49 ? 57  LYS C C   1 
ATOM   4771 O  O   . LYS C 1 57  ? 57.439  -1.105  -19.565 1.00 22.30 ? 57  LYS C O   1 
ATOM   4772 C  CB  . LYS C 1 57  ? 59.393  -0.399  -22.020 1.00 25.61 ? 57  LYS C CB  1 
ATOM   4773 C  CG  . LYS C 1 57  ? 60.742  -0.593  -22.658 1.00 31.55 ? 57  LYS C CG  1 
ATOM   4774 C  CD  . LYS C 1 57  ? 60.534  -0.457  -24.166 1.00 33.01 ? 57  LYS C CD  1 
ATOM   4775 C  CE  . LYS C 1 57  ? 61.862  -0.567  -24.927 1.00 43.84 ? 57  LYS C CE  1 
ATOM   4776 N  NZ  . LYS C 1 57  ? 62.842  0.507   -24.567 1.00 49.71 ? 57  LYS C NZ  1 
ATOM   4777 N  N   . GLN C 1 58  ? 57.622  1.096   -20.013 1.00 17.29 ? 58  GLN C N   1 
ATOM   4778 C  CA  . GLN C 1 58  ? 56.250  1.301   -19.542 1.00 16.10 ? 58  GLN C CA  1 
ATOM   4779 C  C   . GLN C 1 58  ? 55.528  2.247   -20.533 1.00 16.25 ? 58  GLN C C   1 
ATOM   4780 O  O   . GLN C 1 58  ? 56.143  3.017   -21.303 1.00 16.83 ? 58  GLN C O   1 
ATOM   4781 C  CB  . GLN C 1 58  ? 56.236  1.867   -18.080 1.00 16.81 ? 58  GLN C CB  1 
ATOM   4782 C  CG  . GLN C 1 58  ? 56.616  3.311   -18.025 1.00 17.04 ? 58  GLN C CG  1 
ATOM   4783 C  CD  . GLN C 1 58  ? 56.717  3.846   -16.606 1.00 18.38 ? 58  GLN C CD  1 
ATOM   4784 O  OE1 . GLN C 1 58  ? 56.303  3.187   -15.632 1.00 21.78 ? 58  GLN C OE1 1 
ATOM   4785 N  NE2 . GLN C 1 58  ? 57.158  5.040   -16.502 1.00 16.84 ? 58  GLN C NE2 1 
ATOM   4786 N  N   . PHE C 1 59  ? 54.186  2.192   -20.465 1.00 14.95 ? 59  PHE C N   1 
ATOM   4787 C  CA  . PHE C 1 59  ? 53.320  2.823   -21.519 1.00 14.21 ? 59  PHE C CA  1 
ATOM   4788 C  C   . PHE C 1 59  ? 52.196  3.484   -20.845 1.00 14.57 ? 59  PHE C C   1 
ATOM   4789 O  O   . PHE C 1 59  ? 51.663  2.933   -19.897 1.00 15.99 ? 59  PHE C O   1 
ATOM   4790 C  CB  . PHE C 1 59  ? 52.874  1.735   -22.533 1.00 15.66 ? 59  PHE C CB  1 
ATOM   4791 C  CG  . PHE C 1 59  ? 54.070  1.109   -23.168 1.00 16.51 ? 59  PHE C CG  1 
ATOM   4792 C  CD1 . PHE C 1 59  ? 54.675  1.754   -24.262 1.00 16.25 ? 59  PHE C CD1 1 
ATOM   4793 C  CD2 . PHE C 1 59  ? 54.673  -0.022  -22.611 1.00 16.61 ? 59  PHE C CD2 1 
ATOM   4794 C  CE1 . PHE C 1 59  ? 55.859  1.261   -24.790 1.00 16.67 ? 59  PHE C CE1 1 
ATOM   4795 C  CE2 . PHE C 1 59  ? 55.911  -0.517  -23.114 1.00 15.53 ? 59  PHE C CE2 1 
ATOM   4796 C  CZ  . PHE C 1 59  ? 56.485  0.122   -24.236 1.00 16.80 ? 59  PHE C CZ  1 
ATOM   4797 N  N   . LEU C 1 60  ? 51.883  4.717   -21.234 1.00 14.01 ? 60  LEU C N   1 
ATOM   4798 C  CA  . LEU C 1 60  ? 50.964  5.554   -20.555 1.00 15.18 ? 60  LEU C CA  1 
ATOM   4799 C  C   . LEU C 1 60  ? 49.498  5.134   -20.811 1.00 14.48 ? 60  LEU C C   1 
ATOM   4800 O  O   . LEU C 1 60  ? 49.034  5.083   -21.982 1.00 14.10 ? 60  LEU C O   1 
ATOM   4801 C  CB  . LEU C 1 60  ? 51.146  6.981   -21.037 1.00 16.06 ? 60  LEU C CB  1 
ATOM   4802 C  CG  . LEU C 1 60  ? 50.429  8.089   -20.281 1.00 19.14 ? 60  LEU C CG  1 
ATOM   4803 C  CD1 . LEU C 1 60  ? 51.047  8.123   -18.861 1.00 21.65 ? 60  LEU C CD1 1 
ATOM   4804 C  CD2 . LEU C 1 60  ? 50.559  9.425   -21.019 1.00 20.57 ? 60  LEU C CD2 1 
ATOM   4805 N  N   . LEU C 1 61  ? 48.779  4.831   -19.763 1.00 14.19 ? 61  LEU C N   1 
ATOM   4806 C  CA  . LEU C 1 61  ? 47.334  4.578   -19.736 1.00 13.89 ? 61  LEU C CA  1 
ATOM   4807 C  C   . LEU C 1 61  ? 46.605  5.803   -19.270 1.00 15.68 ? 61  LEU C C   1 
ATOM   4808 O  O   . LEU C 1 61  ? 46.984  6.388   -18.220 1.00 15.26 ? 61  LEU C O   1 
ATOM   4809 C  CB  . LEU C 1 61  ? 47.102  3.413   -18.753 1.00 14.41 ? 61  LEU C CB  1 
ATOM   4810 C  CG  . LEU C 1 61  ? 45.800  2.659   -18.786 1.00 16.23 ? 61  LEU C CG  1 
ATOM   4811 C  CD1 . LEU C 1 61  ? 45.667  1.726   -20.046 1.00 17.15 ? 61  LEU C CD1 1 
ATOM   4812 C  CD2 . LEU C 1 61  ? 45.769  1.790   -17.510 1.00 19.35 ? 61  LEU C CD2 1 
ATOM   4813 N  N   . THR C 1 62  ? 45.574  6.217   -19.968 1.00 13.66 ? 62  THR C N   1 
ATOM   4814 C  CA  . THR C 1 62  ? 44.879  7.477   -19.709 1.00 15.72 ? 62  THR C CA  1 
ATOM   4815 C  C   . THR C 1 62  ? 43.401  7.166   -19.724 1.00 17.94 ? 62  THR C C   1 
ATOM   4816 O  O   . THR C 1 62  ? 42.862  6.594   -20.679 1.00 15.88 ? 62  THR C O   1 
ATOM   4817 C  CB  . THR C 1 62  ? 45.104  8.540   -20.782 1.00 18.71 ? 62  THR C CB  1 
ATOM   4818 O  OG1 . THR C 1 62  ? 46.476  8.922   -20.820 1.00 20.35 ? 62  THR C OG1 1 
ATOM   4819 C  CG2 . THR C 1 62  ? 44.220  9.818   -20.490 1.00 22.32 ? 62  THR C CG2 1 
ATOM   4820 N  N   . ASN C 1 63  ? 42.692  7.559   -18.698 1.00 16.79 ? 63  ASN C N   1 
ATOM   4821 C  CA  . ASN C 1 63  ? 41.315  7.817   -18.858 1.00 16.78 ? 63  ASN C CA  1 
ATOM   4822 C  C   . ASN C 1 63  ? 41.035  9.166   -19.418 1.00 17.86 ? 63  ASN C C   1 
ATOM   4823 O  O   . ASN C 1 63  ? 41.287  10.197  -18.756 1.00 18.18 ? 63  ASN C O   1 
ATOM   4824 C  CB  . ASN C 1 63  ? 40.686  7.716   -17.462 1.00 14.81 ? 63  ASN C CB  1 
ATOM   4825 C  CG  . ASN C 1 63  ? 39.182  7.883   -17.460 1.00 17.50 ? 63  ASN C CG  1 
ATOM   4826 O  OD1 . ASN C 1 63  ? 38.609  8.620   -18.255 1.00 17.74 ? 63  ASN C OD1 1 
ATOM   4827 N  ND2 . ASN C 1 63  ? 38.573  7.406   -16.384 1.00 15.73 ? 63  ASN C ND2 1 
ATOM   4828 N  N   . ASN C 1 64  ? 40.467  9.197   -20.640 1.00 20.08 ? 64  ASN C N   1 
ATOM   4829 C  CA  . ASN C 1 64  ? 40.206  10.436  -21.274 1.00 17.81 ? 64  ASN C CA  1 
ATOM   4830 C  C   . ASN C 1 64  ? 38.767  10.863  -21.208 1.00 17.19 ? 64  ASN C C   1 
ATOM   4831 O  O   . ASN C 1 64  ? 38.356  11.798  -21.938 1.00 21.05 ? 64  ASN C O   1 
ATOM   4832 C  CB  . ASN C 1 64  ? 40.748  10.429  -22.726 1.00 17.51 ? 64  ASN C CB  1 
ATOM   4833 C  CG  . ASN C 1 64  ? 40.072  9.450   -23.594 1.00 17.65 ? 64  ASN C CG  1 
ATOM   4834 O  OD1 . ASN C 1 64  ? 38.938  9.009   -23.305 1.00 18.29 ? 64  ASN C OD1 1 
ATOM   4835 N  ND2 . ASN C 1 64  ? 40.797  8.988   -24.635 1.00 21.44 ? 64  ASN C ND2 1 
ATOM   4836 N  N   . GLY C 1 65  ? 37.992  10.201  -20.359 1.00 15.91 ? 65  GLY C N   1 
ATOM   4837 C  CA  . GLY C 1 65  ? 36.567  10.454  -20.241 1.00 18.22 ? 65  GLY C CA  1 
ATOM   4838 C  C   . GLY C 1 65  ? 35.705  9.787   -21.294 1.00 21.07 ? 65  GLY C C   1 
ATOM   4839 O  O   . GLY C 1 65  ? 34.517  9.870   -21.175 1.00 23.42 ? 65  GLY C O   1 
ATOM   4840 N  N   . HIS C 1 66  ? 36.310  9.228   -22.335 1.00 17.86 ? 66  HIS C N   1 
ATOM   4841 C  CA  . HIS C 1 66  ? 35.608  8.480   -23.390 1.00 18.67 ? 66  HIS C CA  1 
ATOM   4842 C  C   . HIS C 1 66  ? 35.929  7.001   -23.366 1.00 15.16 ? 66  HIS C C   1 
ATOM   4843 O  O   . HIS C 1 66  ? 35.042  6.148   -23.543 1.00 19.70 ? 66  HIS C O   1 
ATOM   4844 C  CB  . HIS C 1 66  ? 35.945  9.068   -24.753 1.00 16.18 ? 66  HIS C CB  1 
ATOM   4845 C  CG  . HIS C 1 66  ? 35.744  10.575  -24.815 1.00 16.94 ? 66  HIS C CG  1 
ATOM   4846 N  ND1 . HIS C 1 66  ? 36.771  11.479  -24.993 1.00 20.37 ? 66  HIS C ND1 1 
ATOM   4847 C  CD2 . HIS C 1 66  ? 34.582  11.316  -24.738 1.00 15.81 ? 66  HIS C CD2 1 
ATOM   4848 C  CE1 . HIS C 1 66  ? 36.232  12.739  -25.035 1.00 18.23 ? 66  HIS C CE1 1 
ATOM   4849 N  NE2 . HIS C 1 66  ? 34.890  12.620  -24.812 1.00 20.73 ? 66  HIS C NE2 1 
ATOM   4850 N  N   . SER C 1 67  ? 37.167  6.641   -23.169 1.00 14.91 ? 67  SER C N   1 
ATOM   4851 C  CA  . SER C 1 67  ? 37.615  5.283   -23.061 1.00 15.27 ? 67  SER C CA  1 
ATOM   4852 C  C   . SER C 1 67  ? 38.834  5.303   -22.184 1.00 16.28 ? 67  SER C C   1 
ATOM   4853 O  O   . SER C 1 67  ? 39.060  6.353   -21.531 1.00 19.30 ? 67  SER C O   1 
ATOM   4854 C  CB  . SER C 1 67  ? 37.894  4.672   -24.489 1.00 17.72 ? 67  SER C CB  1 
ATOM   4855 O  OG  . SER C 1 67  ? 38.196  3.275   -24.455 1.00 21.54 ? 67  SER C OG  1 
ATOM   4856 N  N   . VAL C 1 68  ? 39.423  4.125   -22.073 1.00 14.67 ? 68  VAL C N   1 
ATOM   4857 C  CA  . VAL C 1 68  ? 40.771  4.079   -21.518 1.00 16.89 ? 68  VAL C CA  1 
ATOM   4858 C  C   . VAL C 1 68  ? 41.677  3.744   -22.666 1.00 16.64 ? 68  VAL C C   1 
ATOM   4859 O  O   . VAL C 1 68  ? 41.408  2.766   -23.434 1.00 15.86 ? 68  VAL C O   1 
ATOM   4860 C  CB  . VAL C 1 68  ? 40.796  3.093   -20.332 1.00 17.73 ? 68  VAL C CB  1 
ATOM   4861 C  CG1 . VAL C 1 68  ? 40.407  1.644   -20.699 1.00 17.91 ? 68  VAL C CG1 1 
ATOM   4862 C  CG2 . VAL C 1 68  ? 42.160  3.109   -19.658 1.00 19.82 ? 68  VAL C CG2 1 
ATOM   4863 N  N   . LYS C 1 69  ? 42.744  4.535   -22.805 1.00 13.93 ? 69  LYS C N   1 
ATOM   4864 C  CA  . LYS C 1 69  ? 43.652  4.297   -23.887 1.00 13.86 ? 69  LYS C CA  1 
ATOM   4865 C  C   . LYS C 1 69  ? 45.033  4.040   -23.373 1.00 15.84 ? 69  LYS C C   1 
ATOM   4866 O  O   . LYS C 1 69  ? 45.427  4.581   -22.324 1.00 15.11 ? 69  LYS C O   1 
ATOM   4867 C  CB  . LYS C 1 69  ? 43.579  5.402   -24.895 1.00 18.36 ? 69  LYS C CB  1 
ATOM   4868 C  CG  . LYS C 1 69  ? 44.264  6.641   -24.509 1.00 21.10 ? 69  LYS C CG  1 
ATOM   4869 C  CD  . LYS C 1 69  ? 44.313  7.629   -25.671 1.00 24.18 ? 69  LYS C CD  1 
ATOM   4870 C  CE  . LYS C 1 69  ? 44.693  8.932   -25.051 1.00 27.04 ? 69  LYS C CE  1 
ATOM   4871 N  NZ  . LYS C 1 69  ? 45.089  10.005  -26.018 1.00 28.25 ? 69  LYS C NZ  1 
ATOM   4872 N  N   . LEU C 1 70  ? 45.718  3.181   -24.053 1.00 12.20 ? 70  LEU C N   1 
ATOM   4873 C  CA  . LEU C 1 70  ? 47.112  2.863   -23.821 1.00 12.32 ? 70  LEU C CA  1 
ATOM   4874 C  C   . LEU C 1 70  ? 47.932  3.391   -24.979 1.00 12.68 ? 70  LEU C C   1 
ATOM   4875 O  O   . LEU C 1 70  ? 47.768  2.902   -26.086 1.00 11.87 ? 70  LEU C O   1 
ATOM   4876 C  CB  . LEU C 1 70  ? 47.281  1.381   -23.633 1.00 12.56 ? 70  LEU C CB  1 
ATOM   4877 C  CG  . LEU C 1 70  ? 48.664  0.900   -23.308 1.00 13.78 ? 70  LEU C CG  1 
ATOM   4878 C  CD1 . LEU C 1 70  ? 49.088  1.335   -21.890 1.00 13.78 ? 70  LEU C CD1 1 
ATOM   4879 C  CD2 . LEU C 1 70  ? 48.776  -0.618  -23.428 1.00 12.53 ? 70  LEU C CD2 1 
ATOM   4880 N  N   . ASN C 1 71  ? 48.859  4.306   -24.702 1.00 13.07 ? 71  ASN C N   1 
ATOM   4881 C  CA  . ASN C 1 71  ? 49.749  4.797   -25.737 1.00 13.79 ? 71  ASN C CA  1 
ATOM   4882 C  C   . ASN C 1 71  ? 50.682  3.666   -26.149 1.00 12.39 ? 71  ASN C C   1 
ATOM   4883 O  O   . ASN C 1 71  ? 51.091  2.826   -25.350 1.00 14.38 ? 71  ASN C O   1 
ATOM   4884 C  CB  . ASN C 1 71  ? 50.556  6.023   -25.284 1.00 14.18 ? 71  ASN C CB  1 
ATOM   4885 C  CG  . ASN C 1 71  ? 49.718  7.251   -25.186 1.00 17.51 ? 71  ASN C CG  1 
ATOM   4886 O  OD1 . ASN C 1 71  ? 48.527  7.265   -25.506 1.00 19.46 ? 71  ASN C OD1 1 
ATOM   4887 N  ND2 . ASN C 1 71  ? 50.367  8.375   -24.774 1.00 19.21 ? 71  ASN C ND2 1 
ATOM   4888 N  N   . LEU C 1 72  ? 51.024  3.586   -27.454 1.00 11.48 ? 72  LEU C N   1 
ATOM   4889 C  CA  . LEU C 1 72  ? 51.840  2.537   -27.977 1.00 11.03 ? 72  LEU C CA  1 
ATOM   4890 C  C   . LEU C 1 72  ? 52.962  3.178   -28.857 1.00 11.58 ? 72  LEU C C   1 
ATOM   4891 O  O   . LEU C 1 72  ? 52.749  4.285   -29.361 1.00 13.11 ? 72  LEU C O   1 
ATOM   4892 C  CB  . LEU C 1 72  ? 50.997  1.623   -28.928 1.00 11.47 ? 72  LEU C CB  1 
ATOM   4893 C  CG  . LEU C 1 72  ? 49.956  0.720   -28.240 1.00 10.92 ? 72  LEU C CG  1 
ATOM   4894 C  CD1 . LEU C 1 72  ? 49.114  0.145   -29.365 1.00 11.34 ? 72  LEU C CD1 1 
ATOM   4895 C  CD2 . LEU C 1 72  ? 50.556  -0.379  -27.387 1.00 14.97 ? 72  LEU C CD2 1 
ATOM   4896 N  N   . PRO C 1 73  ? 54.127  2.535   -28.897 1.00 14.01 ? 73  PRO C N   1 
ATOM   4897 C  CA  . PRO C 1 73  ? 55.255  3.181   -29.571 1.00 13.84 ? 73  PRO C CA  1 
ATOM   4898 C  C   . PRO C 1 73  ? 55.218  2.968   -31.085 1.00 15.54 ? 73  PRO C C   1 
ATOM   4899 O  O   . PRO C 1 73  ? 54.723  1.958   -31.528 1.00 15.82 ? 73  PRO C O   1 
ATOM   4900 C  CB  . PRO C 1 73  ? 56.464  2.437   -28.991 1.00 17.01 ? 73  PRO C CB  1 
ATOM   4901 C  CG  . PRO C 1 73  ? 56.012  1.030   -28.714 1.00 13.96 ? 73  PRO C CG  1 
ATOM   4902 C  CD  . PRO C 1 73  ? 54.482  1.179   -28.379 1.00 12.89 ? 73  PRO C CD  1 
ATOM   4903 N  N   . SER C 1 74  ? 55.756  3.967   -31.811 1.00 16.54 ? 74  SER C N   1 
ATOM   4904 C  CA  . SER C 1 74  ? 55.731  3.958   -33.283 1.00 18.79 ? 74  SER C CA  1 
ATOM   4905 C  C   . SER C 1 74  ? 56.642  2.877   -33.874 1.00 19.15 ? 74  SER C C   1 
ATOM   4906 O  O   . SER C 1 74  ? 56.516  2.567   -35.077 1.00 21.24 ? 74  SER C O   1 
ATOM   4907 C  CB  . SER C 1 74  ? 56.032  5.318   -33.838 1.00 21.43 ? 74  SER C CB  1 
ATOM   4908 O  OG  . SER C 1 74  ? 57.354  5.620   -33.546 1.00 25.39 ? 74  SER C OG  1 
ATOM   4909 N  N   . ASP C 1 75  ? 57.465  2.201   -33.061 1.00 18.44 ? 75  ASP C N   1 
ATOM   4910 C  CA  . ASP C 1 75  ? 58.211  1.020   -33.532 1.00 19.03 ? 75  ASP C CA  1 
ATOM   4911 C  C   . ASP C 1 75  ? 57.381  -0.188  -33.787 1.00 18.71 ? 75  ASP C C   1 
ATOM   4912 O  O   . ASP C 1 75  ? 57.804  -1.155  -34.404 1.00 19.77 ? 75  ASP C O   1 
ATOM   4913 C  CB  . ASP C 1 75  ? 59.329  0.653   -32.543 1.00 27.39 ? 75  ASP C CB  1 
ATOM   4914 C  CG  . ASP C 1 75  ? 60.529  1.575   -32.688 1.00 37.76 ? 75  ASP C CG  1 
ATOM   4915 O  OD1 . ASP C 1 75  ? 61.499  1.423   -31.899 1.00 53.48 ? 75  ASP C OD1 1 
ATOM   4916 O  OD2 . ASP C 1 75  ? 60.516  2.463   -33.583 1.00 45.52 ? 75  ASP C OD2 1 
ATOM   4917 N  N   . MET C 1 76  ? 56.157  -0.172  -33.256 1.00 14.18 ? 76  MET C N   1 
ATOM   4918 C  CA  . MET C 1 76  ? 55.248  -1.300  -33.452 1.00 15.02 ? 76  MET C CA  1 
ATOM   4919 C  C   . MET C 1 76  ? 54.554  -0.998  -34.783 1.00 11.97 ? 76  MET C C   1 
ATOM   4920 O  O   . MET C 1 76  ? 54.083  0.123   -34.959 1.00 12.37 ? 76  MET C O   1 
ATOM   4921 C  CB  . MET C 1 76  ? 54.060  -1.350  -32.447 1.00 16.46 ? 76  MET C CB  1 
ATOM   4922 C  CG  . MET C 1 76  ? 54.264  -2.037  -31.111 1.00 19.09 ? 76  MET C CG  1 
ATOM   4923 S  SD  . MET C 1 76  ? 52.771  -1.751  -30.130 1.00 20.48 ? 76  MET C SD  1 
ATOM   4924 C  CE  . MET C 1 76  ? 51.512  -2.612  -31.077 1.00 20.28 ? 76  MET C CE  1 
ATOM   4925 N  N   . HIS C 1 77  ? 54.517  -2.003  -35.618 1.00 11.32 ? 77  HIS C N   1 
ATOM   4926 C  CA  . HIS C 1 77  ? 53.848  -1.778  -36.917 1.00 12.83 ? 77  HIS C CA  1 
ATOM   4927 C  C   . HIS C 1 77  ? 53.246  -2.966  -37.533 1.00 13.51 ? 77  HIS C C   1 
ATOM   4928 O  O   . HIS C 1 77  ? 53.565  -4.115  -37.248 1.00 13.40 ? 77  HIS C O   1 
ATOM   4929 C  CB  . HIS C 1 77  ? 54.668  -0.966  -37.891 1.00 19.21 ? 77  HIS C CB  1 
ATOM   4930 C  CG  . HIS C 1 77  ? 55.910  -1.616  -38.247 1.00 20.14 ? 77  HIS C CG  1 
ATOM   4931 N  ND1 . HIS C 1 77  ? 57.071  -1.271  -37.701 1.00 24.91 ? 77  HIS C ND1 1 
ATOM   4932 C  CD2 . HIS C 1 77  ? 56.162  -2.576  -39.172 1.00 23.06 ? 77  HIS C CD2 1 
ATOM   4933 C  CE1 . HIS C 1 77  ? 58.032  -2.006  -38.220 1.00 24.00 ? 77  HIS C CE1 1 
ATOM   4934 N  NE2 . HIS C 1 77  ? 57.480  -2.813  -39.143 1.00 24.72 ? 77  HIS C NE2 1 
ATOM   4935 N  N   . ILE C 1 78  ? 52.318  -2.631  -38.433 1.00 12.67 ? 78  ILE C N   1 
ATOM   4936 C  CA  . ILE C 1 78  ? 51.752  -3.677  -39.306 1.00 14.78 ? 78  ILE C CA  1 
ATOM   4937 C  C   . ILE C 1 78  ? 52.508  -3.696  -40.604 1.00 14.02 ? 78  ILE C C   1 
ATOM   4938 O  O   . ILE C 1 78  ? 52.712  -2.643  -41.205 1.00 15.66 ? 78  ILE C O   1 
ATOM   4939 C  CB  . ILE C 1 78  ? 50.254  -3.371  -39.675 1.00 14.46 ? 78  ILE C CB  1 
ATOM   4940 C  CG1 . ILE C 1 78  ? 49.380  -3.230  -38.417 1.00 15.34 ? 78  ILE C CG1 1 
ATOM   4941 C  CG2 . ILE C 1 78  ? 49.653  -4.334  -40.716 1.00 17.43 ? 78  ILE C CG2 1 
ATOM   4942 C  CD1 . ILE C 1 78  ? 48.013  -2.535  -38.684 1.00 14.89 ? 78  ILE C CD1 1 
ATOM   4943 N  N   . GLN C 1 79  ? 52.940  -4.895  -41.002 1.00 16.28 ? 79  GLN C N   1 
ATOM   4944 C  CA  . GLN C 1 79  ? 53.550  -5.146  -42.291 1.00 20.40 ? 79  GLN C CA  1 
ATOM   4945 C  C   . GLN C 1 79  ? 52.510  -5.988  -43.097 1.00 19.45 ? 79  GLN C C   1 
ATOM   4946 O  O   . GLN C 1 79  ? 51.761  -6.843  -42.544 1.00 17.74 ? 79  GLN C O   1 
ATOM   4947 C  CB  . GLN C 1 79  ? 54.849  -5.936  -41.986 1.00 25.64 ? 79  GLN C CB  1 
ATOM   4948 C  CG  . GLN C 1 79  ? 55.321  -6.906  -43.067 1.00 37.00 ? 79  GLN C CG  1 
ATOM   4949 C  CD  . GLN C 1 79  ? 56.048  -6.215  -44.195 1.00 49.12 ? 79  GLN C CD  1 
ATOM   4950 O  OE1 . GLN C 1 79  ? 56.676  -5.150  -44.004 1.00 52.51 ? 79  GLN C OE1 1 
ATOM   4951 N  NE2 . GLN C 1 79  ? 55.971  -6.816  -45.397 1.00 54.14 ? 79  GLN C NE2 1 
ATOM   4952 N  N   . GLY C 1 80  ? 52.383  -5.669  -44.358 1.00 18.41 ? 80  GLY C N   1 
ATOM   4953 C  CA  . GLY C 1 80  ? 51.409  -6.364  -45.263 1.00 18.66 ? 80  GLY C CA  1 
ATOM   4954 C  C   . GLY C 1 80  ? 50.455  -5.431  -45.988 1.00 21.50 ? 80  GLY C C   1 
ATOM   4955 O  O   . GLY C 1 80  ? 49.815  -5.805  -46.999 1.00 25.36 ? 80  GLY C O   1 
ATOM   4956 N  N   . LEU C 1 81  ? 50.269  -4.197  -45.496 1.00 18.85 ? 81  LEU C N   1 
ATOM   4957 C  CA  . LEU C 1 81  ? 49.362  -3.253  -46.166 1.00 19.00 ? 81  LEU C CA  1 
ATOM   4958 C  C   . LEU C 1 81  ? 50.159  -2.491  -47.224 1.00 21.11 ? 81  LEU C C   1 
ATOM   4959 O  O   . LEU C 1 81  ? 51.365  -2.797  -47.373 1.00 21.84 ? 81  LEU C O   1 
ATOM   4960 C  CB  . LEU C 1 81  ? 48.702  -2.297  -45.150 1.00 17.67 ? 81  LEU C CB  1 
ATOM   4961 C  CG  . LEU C 1 81  ? 47.864  -3.074  -44.163 1.00 17.77 ? 81  LEU C CG  1 
ATOM   4962 C  CD1 . LEU C 1 81  ? 47.368  -2.199  -43.024 1.00 16.48 ? 81  LEU C CD1 1 
ATOM   4963 C  CD2 . LEU C 1 81  ? 46.638  -3.604  -44.952 1.00 17.27 ? 81  LEU C CD2 1 
ATOM   4964 N  N   . GLN C 1 82  ? 49.537  -1.474  -47.842 1.00 21.50 ? 82  GLN C N   1 
ATOM   4965 C  CA  . GLN C 1 82  ? 50.125  -0.706  -48.979 1.00 25.90 ? 82  GLN C CA  1 
ATOM   4966 C  C   . GLN C 1 82  ? 51.238  0.211   -48.505 1.00 24.70 ? 82  GLN C C   1 
ATOM   4967 O  O   . GLN C 1 82  ? 52.149  0.532   -49.260 1.00 25.21 ? 82  GLN C O   1 
ATOM   4968 C  CB  . GLN C 1 82  ? 49.055  0.145   -49.722 1.00 31.32 ? 82  GLN C CB  1 
ATOM   4969 C  CG  . GLN C 1 82  ? 48.086  -0.672  -50.587 1.00 39.11 ? 82  GLN C CG  1 
ATOM   4970 C  CD  . GLN C 1 82  ? 48.665  -2.031  -51.029 1.00 47.47 ? 82  GLN C CD  1 
ATOM   4971 O  OE1 . GLN C 1 82  ? 48.502  -3.064  -50.326 1.00 53.65 ? 82  GLN C OE1 1 
ATOM   4972 N  NE2 . GLN C 1 82  ? 49.372  -2.037  -52.180 1.00 45.72 ? 82  GLN C NE2 1 
ATOM   4973 N  N   . SER C 1 83  ? 51.174  0.628   -47.243 1.00 16.74 ? 83  SER C N   1 
ATOM   4974 C  CA  . SER C 1 83  ? 52.122  1.534   -46.607 1.00 14.73 ? 83  SER C CA  1 
ATOM   4975 C  C   . SER C 1 83  ? 52.379  0.866   -45.278 1.00 12.71 ? 83  SER C C   1 
ATOM   4976 O  O   . SER C 1 83  ? 51.572  0.047   -44.818 1.00 11.72 ? 83  SER C O   1 
ATOM   4977 C  CB  . SER C 1 83  ? 51.510  2.850   -46.280 1.00 15.11 ? 83  SER C CB  1 
ATOM   4978 O  OG  . SER C 1 83  ? 51.231  3.573   -47.511 1.00 17.78 ? 83  SER C OG  1 
ATOM   4979 N  N   . ARG C 1 84  ? 53.474  1.226   -44.618 1.00 12.05 ? 84  ARG C N   1 
ATOM   4980 C  CA  . ARG C 1 84  ? 53.619  0.859   -43.198 1.00 10.79 ? 84  ARG C CA  1 
ATOM   4981 C  C   . ARG C 1 84  ? 52.674  1.636   -42.341 1.00 10.71 ? 84  ARG C C   1 
ATOM   4982 O  O   . ARG C 1 84  ? 52.581  2.836   -42.497 1.00 10.40 ? 84  ARG C O   1 
ATOM   4983 C  CB  . ARG C 1 84  ? 55.053  1.171   -42.713 1.00 11.39 ? 84  ARG C CB  1 
ATOM   4984 C  CG  . ARG C 1 84  ? 55.276  0.726   -41.243 1.00 13.68 ? 84  ARG C CG  1 
ATOM   4985 C  CD  . ARG C 1 84  ? 56.678  1.128   -40.734 1.00 14.14 ? 84  ARG C CD  1 
ATOM   4986 N  NE  . ARG C 1 84  ? 57.540  0.117   -41.209 1.00 13.93 ? 84  ARG C NE  1 
ATOM   4987 C  CZ  . ARG C 1 84  ? 58.867  0.099   -40.900 1.00 14.39 ? 84  ARG C CZ  1 
ATOM   4988 N  NH1 . ARG C 1 84  ? 59.368  1.077   -40.168 1.00 17.02 ? 84  ARG C NH1 1 
ATOM   4989 N  NH2 . ARG C 1 84  ? 59.588  -0.898  -41.324 1.00 17.57 ? 84  ARG C NH2 1 
ATOM   4990 N  N   . TYR C 1 85  ? 51.966  0.942   -41.404 1.00 9.89  ? 85  TYR C N   1 
ATOM   4991 C  CA  . TYR C 1 85  ? 51.154  1.643   -40.435 1.00 9.84  ? 85  TYR C CA  1 
ATOM   4992 C  C   . TYR C 1 85  ? 51.779  1.390   -39.068 1.00 9.58  ? 85  TYR C C   1 
ATOM   4993 O  O   . TYR C 1 85  ? 51.889  0.237   -38.694 1.00 11.22 ? 85  TYR C O   1 
ATOM   4994 C  CB  . TYR C 1 85  ? 49.649  1.084   -40.503 1.00 10.27 ? 85  TYR C CB  1 
ATOM   4995 C  CG  . TYR C 1 85  ? 48.948  1.640   -41.688 1.00 9.00  ? 85  TYR C CG  1 
ATOM   4996 C  CD1 . TYR C 1 85  ? 48.119  2.747   -41.546 1.00 8.96  ? 85  TYR C CD1 1 
ATOM   4997 C  CD2 . TYR C 1 85  ? 49.061  1.027   -42.917 1.00 10.13 ? 85  TYR C CD2 1 
ATOM   4998 C  CE1 . TYR C 1 85  ? 47.439  3.239   -42.650 1.00 8.92  ? 85  TYR C CE1 1 
ATOM   4999 C  CE2 . TYR C 1 85  ? 48.382  1.568   -44.025 1.00 8.99  ? 85  TYR C CE2 1 
ATOM   5000 C  CZ  . TYR C 1 85  ? 47.596  2.681   -43.834 1.00 10.07 ? 85  TYR C CZ  1 
ATOM   5001 O  OH  . TYR C 1 85  ? 46.880  3.270   -44.878 1.00 11.87 ? 85  TYR C OH  1 
ATOM   5002 N  N   . SER C 1 86  ? 52.101  2.463   -38.377 1.00 8.77  ? 86  SER C N   1 
ATOM   5003 C  CA  . SER C 1 86  ? 52.729  2.332   -37.078 1.00 9.86  ? 86  SER C CA  1 
ATOM   5004 C  C   . SER C 1 86  ? 51.698  2.553   -35.980 1.00 9.56  ? 86  SER C C   1 
ATOM   5005 O  O   . SER C 1 86  ? 50.831  3.410   -36.029 1.00 10.71 ? 86  SER C O   1 
ATOM   5006 C  CB  . SER C 1 86  ? 53.837  3.373   -36.958 1.00 10.91 ? 86  SER C CB  1 
ATOM   5007 O  OG  . SER C 1 86  ? 54.831  3.116   -37.945 1.00 12.71 ? 86  SER C OG  1 
ATOM   5008 N  N   . ALA C 1 87  ? 51.961  1.899   -34.873 1.00 10.66 ? 87  ALA C N   1 
ATOM   5009 C  CA  . ALA C 1 87  ? 50.998  1.981   -33.752 1.00 10.75 ? 87  ALA C CA  1 
ATOM   5010 C  C   . ALA C 1 87  ? 50.990  3.366   -33.100 1.00 11.42 ? 87  ALA C C   1 
ATOM   5011 O  O   . ALA C 1 87  ? 52.040  4.099   -33.047 1.00 12.33 ? 87  ALA C O   1 
ATOM   5012 C  CB  . ALA C 1 87  ? 51.278  0.889   -32.757 1.00 10.76 ? 87  ALA C CB  1 
ATOM   5013 N  N   . THR C 1 88  ? 49.830  3.725   -32.565 1.00 9.70  ? 88  THR C N   1 
ATOM   5014 C  CA  . THR C 1 88  ? 49.713  4.928   -31.750 1.00 10.09 ? 88  THR C CA  1 
ATOM   5015 C  C   . THR C 1 88  ? 49.066  4.720   -30.381 1.00 11.22 ? 88  THR C C   1 
ATOM   5016 O  O   . THR C 1 88  ? 49.507  5.296   -29.383 1.00 11.42 ? 88  THR C O   1 
ATOM   5017 C  CB  . THR C 1 88  ? 49.158  6.145   -32.504 1.00 10.55 ? 88  THR C CB  1 
ATOM   5018 O  OG1 . THR C 1 88  ? 49.098  7.300   -31.683 1.00 11.85 ? 88  THR C OG1 1 
ATOM   5019 C  CG2 . THR C 1 88  ? 47.744  5.935   -33.043 1.00 11.18 ? 88  THR C CG2 1 
ATOM   5020 N  N   . GLN C 1 89  ? 48.006  3.910   -30.316 1.00 10.73 ? 89  GLN C N   1 
ATOM   5021 C  CA  . GLN C 1 89  ? 47.290  3.656   -29.038 1.00 10.68 ? 89  GLN C CA  1 
ATOM   5022 C  C   . GLN C 1 89  ? 46.379  2.456   -29.247 1.00 10.39 ? 89  GLN C C   1 
ATOM   5023 O  O   . GLN C 1 89  ? 45.998  2.155   -30.409 1.00 10.16 ? 89  GLN C O   1 
ATOM   5024 C  CB  . GLN C 1 89  ? 46.549  4.882   -28.573 1.00 11.14 ? 89  GLN C CB  1 
ATOM   5025 C  CG  . GLN C 1 89  ? 45.587  5.456   -29.581 1.00 12.82 ? 89  GLN C CG  1 
ATOM   5026 C  CD  . GLN C 1 89  ? 44.172  5.171   -29.145 1.00 13.14 ? 89  GLN C CD  1 
ATOM   5027 O  OE1 . GLN C 1 89  ? 43.856  4.006   -28.929 1.00 13.43 ? 89  GLN C OE1 1 
ATOM   5028 N  NE2 . GLN C 1 89  ? 43.380  6.163   -28.987 1.00 17.86 ? 89  GLN C NE2 1 
ATOM   5029 N  N   . LEU C 1 90  ? 45.980  1.830   -28.155 1.00 9.53  ? 90  LEU C N   1 
ATOM   5030 C  CA  . LEU C 1 90  ? 44.810  1.006   -28.154 1.00 9.31  ? 90  LEU C CA  1 
ATOM   5031 C  C   . LEU C 1 90  ? 43.851  1.423   -27.165 1.00 10.65 ? 90  LEU C C   1 
ATOM   5032 O  O   . LEU C 1 90  ? 44.156  2.158   -26.227 1.00 9.97  ? 90  LEU C O   1 
ATOM   5033 C  CB  . LEU C 1 90  ? 45.200  -0.460  -28.049 1.00 9.58  ? 90  LEU C CB  1 
ATOM   5034 C  CG  . LEU C 1 90  ? 45.952  -0.859  -26.728 1.00 9.61  ? 90  LEU C CG  1 
ATOM   5035 C  CD1 . LEU C 1 90  ? 45.040  -0.962  -25.502 1.00 10.21 ? 90  LEU C CD1 1 
ATOM   5036 C  CD2 . LEU C 1 90  ? 46.566  -2.200  -26.930 1.00 10.17 ? 90  LEU C CD2 1 
ATOM   5037 N  N   . HIS C 1 91  ? 42.625  0.928   -27.286 1.00 9.24  ? 91  HIS C N   1 
ATOM   5038 C  CA  . HIS C 1 91  ? 41.548  1.302   -26.391 1.00 7.89  ? 91  HIS C CA  1 
ATOM   5039 C  C   . HIS C 1 91  ? 40.420  0.264   -26.546 1.00 7.86  ? 91  HIS C C   1 
ATOM   5040 O  O   . HIS C 1 91  ? 40.498  -0.609  -27.407 1.00 8.69  ? 91  HIS C O   1 
ATOM   5041 C  CB  . HIS C 1 91  ? 41.038  2.699   -26.597 1.00 8.62  ? 91  HIS C CB  1 
ATOM   5042 C  CG  . HIS C 1 91  ? 40.452  2.863   -27.955 1.00 7.44  ? 91  HIS C CG  1 
ATOM   5043 N  ND1 . HIS C 1 91  ? 41.214  3.286   -29.037 1.00 8.38  ? 91  HIS C ND1 1 
ATOM   5044 C  CD2 . HIS C 1 91  ? 39.181  2.620   -28.398 1.00 8.29  ? 91  HIS C CD2 1 
ATOM   5045 C  CE1 . HIS C 1 91  ? 40.458  3.258   -30.134 1.00 7.40  ? 91  HIS C CE1 1 
ATOM   5046 N  NE2 . HIS C 1 91  ? 39.227  2.784   -29.774 1.00 6.19  ? 91  HIS C NE2 1 
ATOM   5047 N  N   . LEU C 1 92  ? 39.415  0.349   -25.657 1.00 8.06  ? 92  LEU C N   1 
ATOM   5048 C  CA  . LEU C 1 92  ? 38.296  -0.604  -25.700 1.00 9.92  ? 92  LEU C CA  1 
ATOM   5049 C  C   . LEU C 1 92  ? 36.988  0.159   -25.666 1.00 7.24  ? 92  LEU C C   1 
ATOM   5050 O  O   . LEU C 1 92  ? 36.827  1.317   -25.397 1.00 9.55  ? 92  LEU C O   1 
ATOM   5051 C  CB  . LEU C 1 92  ? 38.351  -1.518  -24.449 1.00 10.83 ? 92  LEU C CB  1 
ATOM   5052 C  CG  . LEU C 1 92  ? 39.538  -2.438  -24.537 1.00 11.14 ? 92  LEU C CG  1 
ATOM   5053 C  CD1 . LEU C 1 92  ? 40.627  -2.010  -23.551 1.00 14.38 ? 92  LEU C CD1 1 
ATOM   5054 C  CD2 . LEU C 1 92  ? 39.281  -3.880  -24.289 1.00 13.26 ? 92  LEU C CD2 1 
ATOM   5055 N  N   . HIS C 1 93  ? 35.964  -0.620  -26.079 1.00 8.30  ? 93  HIS C N   1 
ATOM   5056 C  CA  . HIS C 1 93  ? 34.577  -0.265  -26.011 1.00 7.72  ? 93  HIS C CA  1 
ATOM   5057 C  C   . HIS C 1 93  ? 33.800  -1.404  -25.342 1.00 7.31  ? 93  HIS C C   1 
ATOM   5058 O  O   . HIS C 1 93  ? 34.037  -2.528  -25.608 1.00 8.12  ? 93  HIS C O   1 
ATOM   5059 C  CB  . HIS C 1 93  ? 34.027  -0.068  -27.459 1.00 7.34  ? 93  HIS C CB  1 
ATOM   5060 C  CG  . HIS C 1 93  ? 34.795  0.972   -28.281 1.00 6.94  ? 93  HIS C CG  1 
ATOM   5061 N  ND1 . HIS C 1 93  ? 34.510  2.289   -28.284 1.00 7.59  ? 93  HIS C ND1 1 
ATOM   5062 C  CD2 . HIS C 1 93  ? 35.890  0.785   -29.049 1.00 7.29  ? 93  HIS C CD2 1 
ATOM   5063 C  CE1 . HIS C 1 93  ? 35.384  2.909   -29.111 1.00 7.78  ? 93  HIS C CE1 1 
ATOM   5064 N  NE2 . HIS C 1 93  ? 36.209  1.998   -29.561 1.00 5.93  ? 93  HIS C NE2 1 
ATOM   5065 N  N   . TRP C 1 94  ? 32.837  -0.982  -24.545 1.00 8.59  ? 94  TRP C N   1 
ATOM   5066 C  CA  . TRP C 1 94  ? 32.041  -1.947  -23.789 1.00 8.20  ? 94  TRP C CA  1 
ATOM   5067 C  C   . TRP C 1 94  ? 30.665  -1.393  -23.541 1.00 7.81  ? 94  TRP C C   1 
ATOM   5068 O  O   . TRP C 1 94  ? 30.318  -0.227  -23.760 1.00 7.74  ? 94  TRP C O   1 
ATOM   5069 C  CB  . TRP C 1 94  ? 32.758  -2.430  -22.468 1.00 9.18  ? 94  TRP C CB  1 
ATOM   5070 C  CG  . TRP C 1 94  ? 33.048  -1.301  -21.541 1.00 11.01 ? 94  TRP C CG  1 
ATOM   5071 C  CD1 . TRP C 1 94  ? 32.221  -0.753  -20.579 1.00 11.42 ? 94  TRP C CD1 1 
ATOM   5072 C  CD2 . TRP C 1 94  ? 34.243  -0.429  -21.525 1.00 9.89  ? 94  TRP C CD2 1 
ATOM   5073 N  NE1 . TRP C 1 94  ? 32.816  0.314   -19.922 1.00 10.98 ? 94  TRP C NE1 1 
ATOM   5074 C  CE2 . TRP C 1 94  ? 34.066  0.521   -20.435 1.00 10.98 ? 94  TRP C CE2 1 
ATOM   5075 C  CE3 . TRP C 1 94  ? 35.436  -0.370  -22.290 1.00 11.15 ? 94  TRP C CE3 1 
ATOM   5076 C  CZ2 . TRP C 1 94  ? 34.990  1.501   -20.164 1.00 11.35 ? 94  TRP C CZ2 1 
ATOM   5077 C  CZ3 . TRP C 1 94  ? 36.362  0.627   -21.971 1.00 11.26 ? 94  TRP C CZ3 1 
ATOM   5078 C  CH2 . TRP C 1 94  ? 36.160  1.501   -20.915 1.00 11.64 ? 94  TRP C CH2 1 
ATOM   5079 N  N   . GLY C 1 95  ? 29.899  -2.333  -22.934 1.00 9.54  ? 95  GLY C N   1 
ATOM   5080 C  CA  . GLY C 1 95  ? 28.508  -2.087  -22.563 1.00 10.53 ? 95  GLY C CA  1 
ATOM   5081 C  C   . GLY C 1 95  ? 28.322  -1.690  -21.086 1.00 10.74 ? 95  GLY C C   1 
ATOM   5082 O  O   . GLY C 1 95  ? 28.871  -0.691  -20.564 1.00 11.63 ? 95  GLY C O   1 
ATOM   5083 N  N   . ASN C 1 96  ? 27.419  -2.478  -20.471 1.00 13.20 ? 96  ASN C N   1 
ATOM   5084 C  CA  . ASN C 1 96  ? 27.145  -2.223  -19.025 1.00 14.67 ? 96  ASN C CA  1 
ATOM   5085 C  C   . ASN C 1 96  ? 26.692  -3.521  -18.416 1.00 15.45 ? 96  ASN C C   1 
ATOM   5086 O  O   . ASN C 1 96  ? 26.460  -4.509  -19.097 1.00 14.27 ? 96  ASN C O   1 
ATOM   5087 C  CB  . ASN C 1 96  ? 26.150  -1.115  -18.863 1.00 14.46 ? 96  ASN C CB  1 
ATOM   5088 C  CG  . ASN C 1 96  ? 24.743  -1.505  -19.242 1.00 20.13 ? 96  ASN C CG  1 
ATOM   5089 O  OD1 . ASN C 1 96  ? 24.052  -2.123  -18.433 1.00 24.49 ? 96  ASN C OD1 1 
ATOM   5090 N  ND2 . ASN C 1 96  ? 24.265  -1.058  -20.419 1.00 20.68 ? 96  ASN C ND2 1 
ATOM   5091 N  N   . PRO C 1 97  ? 26.732  -3.628  -17.058 1.00 17.11 ? 97  PRO C N   1 
ATOM   5092 C  CA  . PRO C 1 97  ? 26.457  -4.942  -16.470 1.00 17.10 ? 97  PRO C CA  1 
ATOM   5093 C  C   . PRO C 1 97  ? 25.020  -5.408  -16.710 1.00 16.85 ? 97  PRO C C   1 
ATOM   5094 O  O   . PRO C 1 97  ? 24.811  -6.587  -16.788 1.00 17.88 ? 97  PRO C O   1 
ATOM   5095 C  CB  . PRO C 1 97  ? 26.577  -4.639  -14.963 1.00 16.98 ? 97  PRO C CB  1 
ATOM   5096 C  CG  . PRO C 1 97  ? 27.539  -3.527  -14.855 1.00 18.77 ? 97  PRO C CG  1 
ATOM   5097 C  CD  . PRO C 1 97  ? 27.307  -2.668  -16.082 1.00 18.80 ? 97  PRO C CD  1 
ATOM   5098 N  N   . ASN C 1 98  ? 24.110  -4.465  -16.929 1.00 17.46 ? 98  ASN C N   1 
ATOM   5099 C  CA  . ASN C 1 98  ? 22.682  -4.910  -17.271 1.00 20.15 ? 98  ASN C CA  1 
ATOM   5100 C  C   . ASN C 1 98  ? 22.486  -5.389  -18.720 1.00 21.05 ? 98  ASN C C   1 
ATOM   5101 O  O   . ASN C 1 98  ? 21.562  -6.151  -19.029 1.00 22.71 ? 98  ASN C O   1 
ATOM   5102 C  CB  . ASN C 1 98  ? 21.693  -3.800  -16.993 1.00 22.05 ? 98  ASN C CB  1 
ATOM   5103 C  CG  . ASN C 1 98  ? 21.641  -3.468  -15.524 1.00 30.84 ? 98  ASN C CG  1 
ATOM   5104 O  OD1 . ASN C 1 98  ? 21.633  -4.364  -14.670 1.00 32.96 ? 98  ASN C OD1 1 
ATOM   5105 N  ND2 . ASN C 1 98  ? 21.705  -2.193  -15.223 1.00 33.12 ? 98  ASN C ND2 1 
ATOM   5106 N  N   . ASP C 1 99  ? 23.369  -4.932  -19.597 1.00 16.74 ? 99  ASP C N   1 
ATOM   5107 C  CA  . ASP C 1 99  ? 23.323  -5.206  -21.066 1.00 15.89 ? 99  ASP C CA  1 
ATOM   5108 C  C   . ASP C 1 99  ? 24.798  -5.327  -21.571 1.00 13.64 ? 99  ASP C C   1 
ATOM   5109 O  O   . ASP C 1 99  ? 25.293  -4.358  -22.174 1.00 14.08 ? 99  ASP C O   1 
ATOM   5110 C  CB  . ASP C 1 99  ? 22.552  -4.072  -21.760 1.00 15.58 ? 99  ASP C CB  1 
ATOM   5111 C  CG  . ASP C 1 99  ? 22.024  -4.467  -23.117 1.00 17.20 ? 99  ASP C CG  1 
ATOM   5112 O  OD1 . ASP C 1 99  ? 22.305  -5.583  -23.531 1.00 21.34 ? 99  ASP C OD1 1 
ATOM   5113 O  OD2 . ASP C 1 99  ? 21.434  -3.586  -23.738 1.00 23.10 ? 99  ASP C OD2 1 
ATOM   5114 N  N   . PRO C 1 100 ? 25.425  -6.453  -21.317 1.00 14.30 ? 100 PRO C N   1 
ATOM   5115 C  CA  . PRO C 1 100 ? 26.858  -6.531  -21.475 1.00 13.92 ? 100 PRO C CA  1 
ATOM   5116 C  C   . PRO C 1 100 ? 27.210  -6.873  -22.910 1.00 13.18 ? 100 PRO C C   1 
ATOM   5117 O  O   . PRO C 1 100 ? 27.796  -7.881  -23.243 1.00 13.13 ? 100 PRO C O   1 
ATOM   5118 C  CB  . PRO C 1 100 ? 27.264  -7.589  -20.465 1.00 16.68 ? 100 PRO C CB  1 
ATOM   5119 C  CG  . PRO C 1 100 ? 26.133  -8.515  -20.422 1.00 17.95 ? 100 PRO C CG  1 
ATOM   5120 C  CD  . PRO C 1 100 ? 24.945  -7.628  -20.539 1.00 13.52 ? 100 PRO C CD  1 
ATOM   5121 N  N   . HIS C 1 101 ? 26.783  -5.957  -23.765 1.00 12.65 ? 101 HIS C N   1 
ATOM   5122 C  CA  . HIS C 1 101 ? 26.969  -6.189  -25.248 1.00 12.79 ? 101 HIS C CA  1 
ATOM   5123 C  C   . HIS C 1 101 ? 27.362  -4.927  -25.944 1.00 15.24 ? 101 HIS C C   1 
ATOM   5124 O  O   . HIS C 1 101 ? 26.578  -4.382  -26.701 1.00 16.76 ? 101 HIS C O   1 
ATOM   5125 C  CB  . HIS C 1 101 ? 25.656  -6.726  -25.858 1.00 15.50 ? 101 HIS C CB  1 
ATOM   5126 C  CG  . HIS C 1 101 ? 25.093  -7.911  -25.103 1.00 17.18 ? 101 HIS C CG  1 
ATOM   5127 N  ND1 . HIS C 1 101 ? 25.607  -9.164  -25.185 1.00 16.38 ? 101 HIS C ND1 1 
ATOM   5128 C  CD2 . HIS C 1 101 ? 24.065  -7.961  -24.135 1.00 17.95 ? 101 HIS C CD2 1 
ATOM   5129 C  CE1 . HIS C 1 101 ? 24.881  -9.995  -24.358 1.00 19.04 ? 101 HIS C CE1 1 
ATOM   5130 N  NE2 . HIS C 1 101 ? 23.966  -9.248  -23.734 1.00 19.20 ? 101 HIS C NE2 1 
ATOM   5131 N  N   . GLY C 1 102 ? 28.593  -4.503  -25.776 1.00 12.27 ? 102 GLY C N   1 
ATOM   5132 C  CA  . GLY C 1 102 ? 29.035  -3.232  -26.192 1.00 10.07 ? 102 GLY C CA  1 
ATOM   5133 C  C   . GLY C 1 102 ? 30.209  -3.194  -27.158 1.00 8.71  ? 102 GLY C C   1 
ATOM   5134 O  O   . GLY C 1 102 ? 30.897  -2.149  -27.225 1.00 8.86  ? 102 GLY C O   1 
ATOM   5135 N  N   . SER C 1 103 ? 30.299  -4.215  -28.008 1.00 8.44  ? 103 SER C N   1 
ATOM   5136 C  CA  . SER C 1 103 ? 31.160  -4.071  -29.189 1.00 8.25  ? 103 SER C CA  1 
ATOM   5137 C  C   . SER C 1 103 ? 30.602  -2.977  -30.122 1.00 8.00  ? 103 SER C C   1 
ATOM   5138 O  O   . SER C 1 103 ? 29.406  -2.605  -30.052 1.00 9.91  ? 103 SER C O   1 
ATOM   5139 C  CB  . SER C 1 103 ? 31.309  -5.361  -29.969 1.00 8.04  ? 103 SER C CB  1 
ATOM   5140 O  OG  . SER C 1 103 ? 30.065  -5.775  -30.600 1.00 7.55  ? 103 SER C OG  1 
ATOM   5141 N  N   . GLU C 1 104 ? 31.478  -2.445  -30.956 1.00 6.56  ? 104 GLU C N   1 
ATOM   5142 C  CA  . GLU C 1 104 ? 31.051  -1.487  -31.997 1.00 6.65  ? 104 GLU C CA  1 
ATOM   5143 C  C   . GLU C 1 104 ? 30.565  -2.222  -33.227 1.00 6.29  ? 104 GLU C C   1 
ATOM   5144 O  O   . GLU C 1 104 ? 29.455  -1.980  -33.681 1.00 6.03  ? 104 GLU C O   1 
ATOM   5145 C  CB  . GLU C 1 104 ? 32.205  -0.522  -32.317 1.00 6.81  ? 104 GLU C CB  1 
ATOM   5146 C  CG  . GLU C 1 104 ? 32.753  0.192   -31.068 1.00 8.24  ? 104 GLU C CG  1 
ATOM   5147 C  CD  . GLU C 1 104 ? 33.056  1.602   -31.371 1.00 8.65  ? 104 GLU C CD  1 
ATOM   5148 O  OE1 . GLU C 1 104 ? 34.115  1.742   -32.030 1.00 8.83  ? 104 GLU C OE1 1 
ATOM   5149 O  OE2 . GLU C 1 104 ? 32.287  2.548   -31.112 1.00 9.92  ? 104 GLU C OE2 1 
ATOM   5150 N  N   . HIS C 1 105 ? 31.404  -3.035  -33.841 1.00 5.86  ? 105 HIS C N   1 
ATOM   5151 C  CA  . HIS C 1 105 ? 30.902  -3.913  -34.942 1.00 5.87  ? 105 HIS C CA  1 
ATOM   5152 C  C   . HIS C 1 105 ? 30.003  -4.955  -34.413 1.00 6.23  ? 105 HIS C C   1 
ATOM   5153 O  O   . HIS C 1 105 ? 30.148  -5.428  -33.269 1.00 8.16  ? 105 HIS C O   1 
ATOM   5154 C  CB  . HIS C 1 105 ? 32.089  -4.496  -35.664 1.00 5.95  ? 105 HIS C CB  1 
ATOM   5155 C  CG  . HIS C 1 105 ? 32.894  -3.471  -36.428 1.00 6.56  ? 105 HIS C CG  1 
ATOM   5156 N  ND1 . HIS C 1 105 ? 33.935  -2.770  -35.821 1.00 6.31  ? 105 HIS C ND1 1 
ATOM   5157 C  CD2 . HIS C 1 105 ? 32.739  -2.926  -37.692 1.00 6.65  ? 105 HIS C CD2 1 
ATOM   5158 C  CE1 . HIS C 1 105 ? 34.415  -1.865  -36.707 1.00 7.45  ? 105 HIS C CE1 1 
ATOM   5159 N  NE2 . HIS C 1 105 ? 33.704  -1.965  -37.855 1.00 7.50  ? 105 HIS C NE2 1 
ATOM   5160 N  N   . THR C 1 106 ? 29.081  -5.348  -35.273 1.00 6.18  ? 106 THR C N   1 
ATOM   5161 C  CA  . THR C 1 106 ? 28.171  -6.460  -34.976 1.00 6.21  ? 106 THR C CA  1 
ATOM   5162 C  C   . THR C 1 106 ? 28.369  -7.477  -36.054 1.00 6.79  ? 106 THR C C   1 
ATOM   5163 O  O   . THR C 1 106 ? 28.838  -7.147  -37.152 1.00 7.24  ? 106 THR C O   1 
ATOM   5164 C  CB  . THR C 1 106 ? 26.722  -6.040  -34.847 1.00 6.42  ? 106 THR C CB  1 
ATOM   5165 O  OG1 . THR C 1 106 ? 26.289  -5.463  -36.081 1.00 7.89  ? 106 THR C OG1 1 
ATOM   5166 C  CG2 . THR C 1 106 ? 26.527  -5.105  -33.707 1.00 8.02  ? 106 THR C CG2 1 
ATOM   5167 N  N   . VAL C 1 107 ? 28.003  -8.761  -35.754 1.00 7.20  ? 107 VAL C N   1 
ATOM   5168 C  CA  . VAL C 1 107 ? 28.070  -9.815  -36.770 1.00 7.93  ? 107 VAL C CA  1 
ATOM   5169 C  C   . VAL C 1 107 ? 26.681  -10.476 -36.808 1.00 7.67  ? 107 VAL C C   1 
ATOM   5170 O  O   . VAL C 1 107 ? 26.180  -10.875 -35.792 1.00 9.24  ? 107 VAL C O   1 
ATOM   5171 C  CB  . VAL C 1 107 ? 29.151  -10.894 -36.418 1.00 8.87  ? 107 VAL C CB  1 
ATOM   5172 C  CG1 . VAL C 1 107 ? 29.124  -11.987 -37.440 1.00 10.35 ? 107 VAL C CG1 1 
ATOM   5173 C  CG2 . VAL C 1 107 ? 30.577  -10.263 -36.235 1.00 10.98 ? 107 VAL C CG2 1 
ATOM   5174 N  N   . SER C 1 108 ? 26.071  -10.444 -37.988 1.00 9.73  ? 108 SER C N   1 
ATOM   5175 C  CA  . SER C 1 108 ? 24.745  -10.943 -38.224 1.00 10.75 ? 108 SER C CA  1 
ATOM   5176 C  C   . SER C 1 108 ? 23.811  -10.304 -37.196 1.00 10.40 ? 108 SER C C   1 
ATOM   5177 O  O   . SER C 1 108 ? 22.934  -11.007 -36.581 1.00 10.61 ? 108 SER C O   1 
ATOM   5178 C  CB  . SER C 1 108 ? 24.713  -12.510 -38.140 1.00 13.59 ? 108 SER C CB  1 
ATOM   5179 O  OG  . SER C 1 108 ? 25.645  -13.045 -39.112 1.00 17.00 ? 108 SER C OG  1 
ATOM   5180 N  N   . GLY C 1 109 ? 23.987  -8.998  -36.928 1.00 8.81  ? 109 GLY C N   1 
ATOM   5181 C  CA  . GLY C 1 109 ? 23.116  -8.256  -36.066 1.00 9.23  ? 109 GLY C CA  1 
ATOM   5182 C  C   . GLY C 1 109 ? 23.468  -8.308  -34.584 1.00 9.15  ? 109 GLY C C   1 
ATOM   5183 O  O   . GLY C 1 109 ? 22.845  -7.602  -33.794 1.00 11.59 ? 109 GLY C O   1 
ATOM   5184 N  N   . GLN C 1 110 ? 24.382  -9.152  -34.168 1.00 9.15  ? 110 GLN C N   1 
ATOM   5185 C  CA  . GLN C 1 110 ? 24.689  -9.347  -32.763 1.00 9.39  ? 110 GLN C CA  1 
ATOM   5186 C  C   . GLN C 1 110 ? 25.968  -8.606  -32.316 1.00 8.67  ? 110 GLN C C   1 
ATOM   5187 O  O   . GLN C 1 110 ? 27.012  -8.692  -32.986 1.00 8.20  ? 110 GLN C O   1 
ATOM   5188 C  CB  . GLN C 1 110 ? 24.964  -10.825 -32.597 1.00 10.59 ? 110 GLN C CB  1 
ATOM   5189 C  CG  . GLN C 1 110 ? 23.917  -11.747 -33.195 1.00 11.52 ? 110 GLN C CG  1 
ATOM   5190 C  CD  . GLN C 1 110 ? 22.500  -11.341 -32.728 1.00 13.40 ? 110 GLN C CD  1 
ATOM   5191 O  OE1 . GLN C 1 110 ? 22.237  -11.261 -31.527 1.00 15.31 ? 110 GLN C OE1 1 
ATOM   5192 N  NE2 . GLN C 1 110 ? 21.626  -10.997 -33.709 1.00 14.02 ? 110 GLN C NE2 1 
ATOM   5193 N  N   . HIS C 1 111 ? 25.828  -7.936  -31.215 1.00 10.13 ? 111 HIS C N   1 
ATOM   5194 C  CA  . HIS C 1 111 ? 26.979  -7.371  -30.541 1.00 9.97  ? 111 HIS C CA  1 
ATOM   5195 C  C   . HIS C 1 111 ? 27.740  -8.476  -29.853 1.00 11.57 ? 111 HIS C C   1 
ATOM   5196 O  O   . HIS C 1 111 ? 27.210  -9.491  -29.415 1.00 14.34 ? 111 HIS C O   1 
ATOM   5197 C  CB  . HIS C 1 111 ? 26.589  -6.345  -29.478 1.00 11.67 ? 111 HIS C CB  1 
ATOM   5198 C  CG  . HIS C 1 111 ? 26.132  -5.063  -30.035 1.00 12.09 ? 111 HIS C CG  1 
ATOM   5199 N  ND1 . HIS C 1 111 ? 26.943  -3.949  -30.214 1.00 12.20 ? 111 HIS C ND1 1 
ATOM   5200 C  CD2 . HIS C 1 111 ? 24.871  -4.698  -30.524 1.00 12.57 ? 111 HIS C CD2 1 
ATOM   5201 C  CE1 . HIS C 1 111 ? 26.185  -2.946  -30.771 1.00 12.88 ? 111 HIS C CE1 1 
ATOM   5202 N  NE2 . HIS C 1 111 ? 24.907  -3.424  -30.926 1.00 16.33 ? 111 HIS C NE2 1 
ATOM   5203 N  N   . PHE C 1 112 ? 29.009  -8.221  -29.685 1.00 9.80  ? 112 PHE C N   1 
ATOM   5204 C  CA  . PHE C 1 112 ? 29.863  -8.990  -28.761 1.00 9.15  ? 112 PHE C CA  1 
ATOM   5205 C  C   . PHE C 1 112 ? 29.922  -8.201  -27.474 1.00 8.76  ? 112 PHE C C   1 
ATOM   5206 O  O   . PHE C 1 112 ? 29.466  -7.054  -27.410 1.00 9.28  ? 112 PHE C O   1 
ATOM   5207 C  CB  . PHE C 1 112 ? 31.239  -9.205  -29.404 1.00 11.25 ? 112 PHE C CB  1 
ATOM   5208 C  CG  . PHE C 1 112 ? 31.183  -10.246 -30.422 1.00 13.32 ? 112 PHE C CG  1 
ATOM   5209 C  CD1 . PHE C 1 112 ? 31.647  -11.521 -30.144 1.00 13.84 ? 112 PHE C CD1 1 
ATOM   5210 C  CD2 . PHE C 1 112 ? 30.634  -9.977  -31.704 1.00 14.27 ? 112 PHE C CD2 1 
ATOM   5211 C  CE1 . PHE C 1 112 ? 31.556  -12.592 -31.091 1.00 17.63 ? 112 PHE C CE1 1 
ATOM   5212 C  CE2 . PHE C 1 112 ? 30.540  -11.022 -32.653 1.00 18.71 ? 112 PHE C CE2 1 
ATOM   5213 C  CZ  . PHE C 1 112 ? 31.036  -12.283 -32.352 1.00 18.05 ? 112 PHE C CZ  1 
ATOM   5214 N  N   . ALA C 1 113 ? 30.530  -8.789  -26.394 1.00 9.69  ? 113 ALA C N   1 
ATOM   5215 C  CA  . ALA C 1 113 ? 30.577  -8.082  -25.178 1.00 8.05  ? 113 ALA C CA  1 
ATOM   5216 C  C   . ALA C 1 113 ? 31.306  -6.782  -25.158 1.00 7.45  ? 113 ALA C C   1 
ATOM   5217 O  O   . ALA C 1 113 ? 30.957  -5.853  -24.529 1.00 9.89  ? 113 ALA C O   1 
ATOM   5218 C  CB  . ALA C 1 113 ? 31.200  -8.991  -24.099 1.00 9.84  ? 113 ALA C CB  1 
ATOM   5219 N  N   . ALA C 1 114 ? 32.449  -6.811  -25.888 1.00 8.55  ? 114 ALA C N   1 
ATOM   5220 C  CA  . ALA C 1 114 ? 33.317  -5.638  -25.925 1.00 7.65  ? 114 ALA C CA  1 
ATOM   5221 C  C   . ALA C 1 114 ? 34.146  -5.730  -27.216 1.00 7.52  ? 114 ALA C C   1 
ATOM   5222 O  O   . ALA C 1 114 ? 34.065  -6.699  -27.959 1.00 8.11  ? 114 ALA C O   1 
ATOM   5223 C  CB  . ALA C 1 114 ? 34.240  -5.675  -24.701 1.00 10.62 ? 114 ALA C CB  1 
ATOM   5224 N  N   . GLU C 1 115 ? 34.958  -4.683  -27.453 1.00 7.37  ? 115 GLU C N   1 
ATOM   5225 C  CA  . GLU C 1 115 ? 35.785  -4.692  -28.659 1.00 8.64  ? 115 GLU C CA  1 
ATOM   5226 C  C   . GLU C 1 115 ? 37.085  -3.863  -28.317 1.00 7.70  ? 115 GLU C C   1 
ATOM   5227 O  O   . GLU C 1 115 ? 37.007  -2.771  -27.677 1.00 9.78  ? 115 GLU C O   1 
ATOM   5228 C  CB  . GLU C 1 115 ? 35.018  -4.011  -29.774 1.00 7.79  ? 115 GLU C CB  1 
ATOM   5229 C  CG  . GLU C 1 115 ? 35.724  -4.051  -31.177 1.00 8.03  ? 115 GLU C CG  1 
ATOM   5230 C  CD  . GLU C 1 115 ? 34.759  -3.714  -32.320 1.00 8.56  ? 115 GLU C CD  1 
ATOM   5231 O  OE1 . GLU C 1 115 ? 35.268  -3.263  -33.376 1.00 8.71  ? 115 GLU C OE1 1 
ATOM   5232 O  OE2 . GLU C 1 115 ? 33.555  -4.007  -32.197 1.00 8.86  ? 115 GLU C OE2 1 
ATOM   5233 N  N   . LEU C 1 116 ? 38.212  -4.452  -28.717 1.00 8.04  ? 116 LEU C N   1 
ATOM   5234 C  CA  . LEU C 1 116 ? 39.506  -3.755  -28.612 1.00 8.68  ? 116 LEU C CA  1 
ATOM   5235 C  C   . LEU C 1 116 ? 39.918  -3.216  -29.963 1.00 8.10  ? 116 LEU C C   1 
ATOM   5236 O  O   . LEU C 1 116 ? 39.771  -3.972  -30.954 1.00 8.57  ? 116 LEU C O   1 
ATOM   5237 C  CB  . LEU C 1 116 ? 40.532  -4.791  -28.150 1.00 10.64 ? 116 LEU C CB  1 
ATOM   5238 C  CG  . LEU C 1 116 ? 42.045  -4.306  -28.260 1.00 11.16 ? 116 LEU C CG  1 
ATOM   5239 C  CD1 . LEU C 1 116 ? 42.291  -3.438  -27.064 1.00 14.88 ? 116 LEU C CD1 1 
ATOM   5240 C  CD2 . LEU C 1 116 ? 42.939  -5.500  -28.503 1.00 12.79 ? 116 LEU C CD2 1 
ATOM   5241 N  N   . HIS C 1 117 ? 40.391  -2.000  -29.956 1.00 7.79  ? 117 HIS C N   1 
ATOM   5242 C  CA  . HIS C 1 117 ? 40.890  -1.319  -31.164 1.00 6.91  ? 117 HIS C CA  1 
ATOM   5243 C  C   . HIS C 1 117 ? 42.362  -1.024  -30.958 1.00 7.33  ? 117 HIS C C   1 
ATOM   5244 O  O   . HIS C 1 117 ? 42.714  -0.376  -29.950 1.00 8.40  ? 117 HIS C O   1 
ATOM   5245 C  CB  . HIS C 1 117 ? 40.148  -0.059  -31.403 1.00 7.83  ? 117 HIS C CB  1 
ATOM   5246 C  CG  . HIS C 1 117 ? 38.768  -0.350  -31.885 1.00 6.47  ? 117 HIS C CG  1 
ATOM   5247 N  ND1 . HIS C 1 117 ? 37.748  0.561   -31.773 1.00 8.62  ? 117 HIS C ND1 1 
ATOM   5248 C  CD2 . HIS C 1 117 ? 38.256  -1.520  -32.508 1.00 8.55  ? 117 HIS C CD2 1 
ATOM   5249 C  CE1 . HIS C 1 117 ? 36.638  -0.027  -32.307 1.00 7.49  ? 117 HIS C CE1 1 
ATOM   5250 N  NE2 . HIS C 1 117 ? 36.902  -1.245  -32.729 1.00 6.42  ? 117 HIS C NE2 1 
ATOM   5251 N  N   . ILE C 1 118 ? 43.140  -1.461  -31.890 1.00 7.72  ? 118 ILE C N   1 
ATOM   5252 C  CA  . ILE C 1 118 ? 44.597  -1.032  -31.931 1.00 7.81  ? 118 ILE C CA  1 
ATOM   5253 C  C   . ILE C 1 118 ? 44.820  -0.096  -33.111 1.00 6.82  ? 118 ILE C C   1 
ATOM   5254 O  O   . ILE C 1 118 ? 44.660  -0.521  -34.310 1.00 6.93  ? 118 ILE C O   1 
ATOM   5255 C  CB  . ILE C 1 118 ? 45.527  -2.215  -32.039 1.00 8.57  ? 118 ILE C CB  1 
ATOM   5256 C  CG1 . ILE C 1 118 ? 45.195  -3.306  -31.006 1.00 9.33  ? 118 ILE C CG1 1 
ATOM   5257 C  CG2 . ILE C 1 118 ? 47.017  -1.773  -31.893 1.00 10.04 ? 118 ILE C CG2 1 
ATOM   5258 C  CD1 . ILE C 1 118 ? 46.060  -4.544  -31.098 1.00 11.82 ? 118 ILE C CD1 1 
ATOM   5259 N  N   . VAL C 1 119 ? 44.993  1.146   -32.824 1.00 6.72  ? 119 VAL C N   1 
ATOM   5260 C  CA  . VAL C 1 119 ? 45.033  2.238   -33.790 1.00 7.01  ? 119 VAL C CA  1 
ATOM   5261 C  C   . VAL C 1 119 ? 46.441  2.408   -34.291 1.00 7.83  ? 119 VAL C C   1 
ATOM   5262 O  O   . VAL C 1 119 ? 47.370  2.620   -33.497 1.00 9.63  ? 119 VAL C O   1 
ATOM   5263 C  CB  . VAL C 1 119 ? 44.530  3.543   -33.182 1.00 6.98  ? 119 VAL C CB  1 
ATOM   5264 C  CG1 . VAL C 1 119 ? 44.413  4.689   -34.227 1.00 8.39  ? 119 VAL C CG1 1 
ATOM   5265 C  CG2 . VAL C 1 119 ? 43.187  3.303   -32.469 1.00 8.29  ? 119 VAL C CG2 1 
ATOM   5266 N  N   . HIS C 1 120 ? 46.547  2.430   -35.613 1.00 7.21  ? 120 HIS C N   1 
ATOM   5267 C  CA  . HIS C 1 120 ? 47.874  2.718   -36.257 1.00 8.00  ? 120 HIS C CA  1 
ATOM   5268 C  C   . HIS C 1 120 ? 47.675  3.817   -37.238 1.00 8.89  ? 120 HIS C C   1 
ATOM   5269 O  O   . HIS C 1 120 ? 46.593  4.109   -37.757 1.00 8.23  ? 120 HIS C O   1 
ATOM   5270 C  CB  . HIS C 1 120 ? 48.287  1.488   -37.082 1.00 8.55  ? 120 HIS C CB  1 
ATOM   5271 C  CG  . HIS C 1 120 ? 48.430  0.244   -36.357 1.00 9.35  ? 120 HIS C CG  1 
ATOM   5272 N  ND1 . HIS C 1 120 ? 47.370  -0.431  -35.753 1.00 8.91  ? 120 HIS C ND1 1 
ATOM   5273 C  CD2 . HIS C 1 120 ? 49.586  -0.474  -36.051 1.00 9.54  ? 120 HIS C CD2 1 
ATOM   5274 C  CE1 . HIS C 1 120 ? 47.841  -1.554  -35.165 1.00 8.57  ? 120 HIS C CE1 1 
ATOM   5275 N  NE2 . HIS C 1 120 ? 49.201  -1.609  -35.375 1.00 9.78  ? 120 HIS C NE2 1 
ATOM   5276 N  N   . TYR C 1 121 ? 48.792  4.516   -37.610 1.00 8.47  ? 121 TYR C N   1 
ATOM   5277 C  CA  . TYR C 1 121 ? 48.744  5.583   -38.619 1.00 9.64  ? 121 TYR C CA  1 
ATOM   5278 C  C   . TYR C 1 121 ? 49.757  5.313   -39.696 1.00 8.75  ? 121 TYR C C   1 
ATOM   5279 O  O   . TYR C 1 121 ? 50.744  4.574   -39.517 1.00 8.07  ? 121 TYR C O   1 
ATOM   5280 C  CB  . TYR C 1 121 ? 49.084  6.938   -37.922 1.00 10.37 ? 121 TYR C CB  1 
ATOM   5281 C  CG  . TYR C 1 121 ? 50.480  7.180   -37.465 1.00 10.86 ? 121 TYR C CG  1 
ATOM   5282 C  CD1 . TYR C 1 121 ? 51.337  7.983   -38.214 1.00 10.65 ? 121 TYR C CD1 1 
ATOM   5283 C  CD2 . TYR C 1 121 ? 50.921  6.617   -36.282 1.00 11.32 ? 121 TYR C CD2 1 
ATOM   5284 C  CE1 . TYR C 1 121 ? 52.704  8.140   -37.782 1.00 11.31 ? 121 TYR C CE1 1 
ATOM   5285 C  CE2 . TYR C 1 121 ? 52.221  6.810   -35.813 1.00 13.63 ? 121 TYR C CE2 1 
ATOM   5286 C  CZ  . TYR C 1 121 ? 53.064  7.559   -36.583 1.00 13.73 ? 121 TYR C CZ  1 
ATOM   5287 O  OH  . TYR C 1 121 ? 54.381  7.663   -36.112 1.00 18.51 ? 121 TYR C OH  1 
ATOM   5288 N  N   . ASN C 1 122 ? 49.513  5.946   -40.841 1.00 8.94  ? 122 ASN C N   1 
ATOM   5289 C  CA  . ASN C 1 122 ? 50.388  5.727   -42.049 1.00 9.38  ? 122 ASN C CA  1 
ATOM   5290 C  C   . ASN C 1 122 ? 51.646  6.590   -41.929 1.00 10.03 ? 122 ASN C C   1 
ATOM   5291 O  O   . ASN C 1 122 ? 51.607  7.788   -42.167 1.00 9.94  ? 122 ASN C O   1 
ATOM   5292 C  CB  . ASN C 1 122 ? 49.612  6.095   -43.252 1.00 10.27 ? 122 ASN C CB  1 
ATOM   5293 C  CG  . ASN C 1 122 ? 50.300  5.761   -44.487 1.00 10.69 ? 122 ASN C CG  1 
ATOM   5294 O  OD1 . ASN C 1 122 ? 51.548  5.733   -44.542 1.00 11.86 ? 122 ASN C OD1 1 
ATOM   5295 N  ND2 . ASN C 1 122 ? 49.521  5.474   -45.519 1.00 11.01 ? 122 ASN C ND2 1 
ATOM   5296 N  N   . SER C 1 123 ? 52.689  5.894   -41.431 1.00 9.19  ? 123 SER C N   1 
ATOM   5297 C  CA  . SER C 1 123 ? 53.930  6.599   -41.073 1.00 11.27 ? 123 SER C CA  1 
ATOM   5298 C  C   . SER C 1 123 ? 54.785  6.750   -42.330 1.00 12.35 ? 123 SER C C   1 
ATOM   5299 O  O   . SER C 1 123 ? 55.717  7.627   -42.287 1.00 14.73 ? 123 SER C O   1 
ATOM   5300 C  CB  . SER C 1 123 ? 54.618  5.820   -39.952 1.00 11.66 ? 123 SER C CB  1 
ATOM   5301 O  OG  . SER C 1 123 ? 54.826  4.497   -40.258 1.00 11.47 ? 123 SER C OG  1 
ATOM   5302 N  N   . ASP C 1 124 ? 54.440  6.083   -43.426 1.00 11.41 ? 124 ASP C N   1 
ATOM   5303 C  CA  . ASP C 1 124 ? 55.121  6.398   -44.712 1.00 12.29 ? 124 ASP C CA  1 
ATOM   5304 C  C   . ASP C 1 124 ? 54.644  7.755   -45.232 1.00 13.86 ? 124 ASP C C   1 
ATOM   5305 O  O   . ASP C 1 124 ? 55.447  8.564   -45.776 1.00 17.38 ? 124 ASP C O   1 
ATOM   5306 C  CB  . ASP C 1 124 ? 54.844  5.298   -45.729 1.00 11.56 ? 124 ASP C CB  1 
ATOM   5307 C  CG  . ASP C 1 124 ? 55.555  4.018   -45.417 1.00 12.15 ? 124 ASP C CG  1 
ATOM   5308 O  OD1 . ASP C 1 124 ? 56.596  4.052   -44.662 1.00 13.44 ? 124 ASP C OD1 1 
ATOM   5309 O  OD2 . ASP C 1 124 ? 55.187  2.996   -45.974 1.00 12.98 ? 124 ASP C OD2 1 
ATOM   5310 N  N   . LEU C 1 125 ? 53.376  8.085   -45.068 1.00 11.16 ? 125 LEU C N   1 
ATOM   5311 C  CA  . LEU C 1 125 ? 52.848  9.342   -45.576 1.00 12.15 ? 125 LEU C CA  1 
ATOM   5312 C  C   . LEU C 1 125 ? 52.905  10.522  -44.606 1.00 13.12 ? 125 LEU C C   1 
ATOM   5313 O  O   . LEU C 1 125 ? 52.945  11.724  -45.065 1.00 15.04 ? 125 LEU C O   1 
ATOM   5314 C  CB  . LEU C 1 125 ? 51.389  9.165   -46.100 1.00 12.02 ? 125 LEU C CB  1 
ATOM   5315 C  CG  . LEU C 1 125 ? 51.177  8.197   -47.256 1.00 14.55 ? 125 LEU C CG  1 
ATOM   5316 C  CD1 . LEU C 1 125 ? 49.715  8.163   -47.676 1.00 16.36 ? 125 LEU C CD1 1 
ATOM   5317 C  CD2 . LEU C 1 125 ? 52.036  8.603   -48.484 1.00 16.98 ? 125 LEU C CD2 1 
ATOM   5318 N  N   . TYR C 1 126 ? 52.839  10.252  -43.304 1.00 11.23 ? 126 TYR C N   1 
ATOM   5319 C  CA  . TYR C 1 126 ? 52.538  11.301  -42.327 1.00 11.48 ? 126 TYR C CA  1 
ATOM   5320 C  C   . TYR C 1 126 ? 53.459  11.139  -41.147 1.00 13.64 ? 126 TYR C C   1 
ATOM   5321 O  O   . TYR C 1 126 ? 53.857  10.013  -40.798 1.00 13.16 ? 126 TYR C O   1 
ATOM   5322 C  CB  . TYR C 1 126 ? 51.066  11.223  -41.835 1.00 11.87 ? 126 TYR C CB  1 
ATOM   5323 C  CG  . TYR C 1 126 ? 50.133  11.261  -42.978 1.00 11.78 ? 126 TYR C CG  1 
ATOM   5324 C  CD1 . TYR C 1 126 ? 50.053  12.404  -43.847 1.00 13.36 ? 126 TYR C CD1 1 
ATOM   5325 C  CD2 . TYR C 1 126 ? 49.281  10.172  -43.294 1.00 10.93 ? 126 TYR C CD2 1 
ATOM   5326 C  CE1 . TYR C 1 126 ? 49.236  12.397  -44.970 1.00 12.11 ? 126 TYR C CE1 1 
ATOM   5327 C  CE2 . TYR C 1 126 ? 48.459  10.172  -44.396 1.00 11.86 ? 126 TYR C CE2 1 
ATOM   5328 C  CZ  . TYR C 1 126 ? 48.420  11.269  -45.239 1.00 12.32 ? 126 TYR C CZ  1 
ATOM   5329 O  OH  . TYR C 1 126 ? 47.588  11.267  -46.313 1.00 13.95 ? 126 TYR C OH  1 
ATOM   5330 N  N   . PRO C 1 127 ? 53.779  12.267  -40.448 1.00 15.05 ? 127 PRO C N   1 
ATOM   5331 C  CA  . PRO C 1 127 ? 54.828  12.196  -39.452 1.00 15.55 ? 127 PRO C CA  1 
ATOM   5332 C  C   . PRO C 1 127 ? 54.334  11.759  -38.090 1.00 16.69 ? 127 PRO C C   1 
ATOM   5333 O  O   . PRO C 1 127 ? 55.160  11.398  -37.225 1.00 19.02 ? 127 PRO C O   1 
ATOM   5334 C  CB  . PRO C 1 127 ? 55.304  13.677  -39.340 1.00 17.73 ? 127 PRO C CB  1 
ATOM   5335 C  CG  . PRO C 1 127 ? 54.151  14.494  -39.822 1.00 17.23 ? 127 PRO C CG  1 
ATOM   5336 C  CD  . PRO C 1 127 ? 53.483  13.640  -40.883 1.00 15.33 ? 127 PRO C CD  1 
ATOM   5337 N  N   . ASP C 1 128 ? 53.001  11.761  -37.879 1.00 15.46 ? 128 ASP C N   1 
ATOM   5338 C  CA  . ASP C 1 128 ? 52.458  11.358  -36.573 1.00 15.68 ? 128 ASP C CA  1 
ATOM   5339 C  C   . ASP C 1 128 ? 50.972  11.033  -36.746 1.00 13.44 ? 128 ASP C C   1 
ATOM   5340 O  O   . ASP C 1 128 ? 50.351  11.401  -37.773 1.00 13.08 ? 128 ASP C O   1 
ATOM   5341 C  CB  . ASP C 1 128 ? 52.707  12.476  -35.489 1.00 17.67 ? 128 ASP C CB  1 
ATOM   5342 C  CG  . ASP C 1 128 ? 52.260  13.803  -35.898 1.00 23.92 ? 128 ASP C CG  1 
ATOM   5343 O  OD1 . ASP C 1 128 ? 53.070  14.777  -35.743 1.00 30.67 ? 128 ASP C OD1 1 
ATOM   5344 O  OD2 . ASP C 1 128 ? 51.109  13.941  -36.282 1.00 25.37 ? 128 ASP C OD2 1 
ATOM   5345 N  N   . ALA C 1 129 ? 50.373  10.456  -35.707 1.00 13.28 ? 129 ALA C N   1 
ATOM   5346 C  CA  . ALA C 1 129 ? 49.010  10.072  -35.803 1.00 13.89 ? 129 ALA C CA  1 
ATOM   5347 C  C   . ALA C 1 129 ? 47.977  11.200  -35.937 1.00 13.92 ? 129 ALA C C   1 
ATOM   5348 O  O   . ALA C 1 129 ? 47.000  11.101  -36.677 1.00 14.70 ? 129 ALA C O   1 
ATOM   5349 C  CB  . ALA C 1 129 ? 48.680  9.189   -34.610 1.00 14.86 ? 129 ALA C CB  1 
ATOM   5350 N  N   . SER C 1 130 ? 48.200  12.246  -35.161 1.00 16.67 ? 130 SER C N   1 
ATOM   5351 C  CA  . SER C 1 130 ? 47.353  13.389  -35.247 1.00 17.53 ? 130 SER C CA  1 
ATOM   5352 C  C   . SER C 1 130 ? 47.285  13.961  -36.640 1.00 16.00 ? 130 SER C C   1 
ATOM   5353 O  O   . SER C 1 130 ? 46.190  14.242  -37.162 1.00 17.87 ? 130 SER C O   1 
ATOM   5354 C  CB  . SER C 1 130 ? 47.958  14.437  -34.311 1.00 20.71 ? 130 SER C CB  1 
ATOM   5355 O  OG  . SER C 1 130 ? 46.928  15.331  -33.994 1.00 34.27 ? 130 SER C OG  1 
ATOM   5356 N  N   . THR C 1 131 ? 48.470  14.120  -37.282 1.00 14.26 ? 131 THR C N   1 
ATOM   5357 C  CA  . THR C 1 131 ? 48.477  14.741  -38.615 1.00 14.29 ? 131 THR C CA  1 
ATOM   5358 C  C   . THR C 1 131 ? 47.766  13.757  -39.552 1.00 13.37 ? 131 THR C C   1 
ATOM   5359 O  O   . THR C 1 131 ? 47.118  14.181  -40.524 1.00 12.62 ? 131 THR C O   1 
ATOM   5360 C  CB  . THR C 1 131 ? 49.926  14.955  -39.120 1.00 15.52 ? 131 THR C CB  1 
ATOM   5361 O  OG1 . THR C 1 131 ? 50.602  15.751  -38.121 1.00 18.52 ? 131 THR C OG1 1 
ATOM   5362 C  CG2 . THR C 1 131 ? 49.981  15.612  -40.532 1.00 15.50 ? 131 THR C CG2 1 
ATOM   5363 N  N   . ALA C 1 132 ? 48.030  12.445  -39.318 1.00 11.44 ? 132 ALA C N   1 
ATOM   5364 C  CA  . ALA C 1 132 ? 47.429  11.450  -40.257 1.00 12.18 ? 132 ALA C CA  1 
ATOM   5365 C  C   . ALA C 1 132 ? 45.910  11.333  -40.199 1.00 11.36 ? 132 ALA C C   1 
ATOM   5366 O  O   . ALA C 1 132 ? 45.293  10.965  -41.175 1.00 10.40 ? 132 ALA C O   1 
ATOM   5367 C  CB  . ALA C 1 132 ? 47.973  10.030  -39.994 1.00 9.66  ? 132 ALA C CB  1 
ATOM   5368 N  N   . SER C 1 133 ? 45.362  11.664  -39.043 1.00 11.92 ? 133 SER C N   1 
ATOM   5369 C  CA  . SER C 1 133 ? 44.000  11.220  -38.736 1.00 12.86 ? 133 SER C CA  1 
ATOM   5370 C  C   . SER C 1 133 ? 42.939  11.793  -39.628 1.00 13.76 ? 133 SER C C   1 
ATOM   5371 O  O   . SER C 1 133 ? 41.858  11.173  -39.857 1.00 12.93 ? 133 SER C O   1 
ATOM   5372 C  CB  . SER C 1 133 ? 43.703  11.472  -37.255 1.00 12.20 ? 133 SER C CB  1 
ATOM   5373 O  OG  . SER C 1 133 ? 43.648  12.934  -37.016 1.00 12.92 ? 133 SER C OG  1 
ATOM   5374 N  N   . ASN C 1 134 ? 43.161  12.931  -40.216 1.00 11.79 ? 134 ASN C N   1 
ATOM   5375 C  CA  . ASN C 1 134 ? 42.208  13.569  -41.103 1.00 14.53 ? 134 ASN C CA  1 
ATOM   5376 C  C   . ASN C 1 134 ? 42.622  13.571  -42.557 1.00 13.79 ? 134 ASN C C   1 
ATOM   5377 O  O   . ASN C 1 134 ? 42.082  14.278  -43.404 1.00 17.71 ? 134 ASN C O   1 
ATOM   5378 C  CB  . ASN C 1 134 ? 41.851  14.980  -40.592 1.00 15.16 ? 134 ASN C CB  1 
ATOM   5379 C  CG  . ASN C 1 134 ? 42.984  15.959  -40.753 1.00 16.22 ? 134 ASN C CG  1 
ATOM   5380 O  OD1 . ASN C 1 134 ? 44.139  15.581  -40.814 1.00 17.68 ? 134 ASN C OD1 1 
ATOM   5381 N  ND2 . ASN C 1 134 ? 42.624  17.262  -40.918 1.00 19.40 ? 134 ASN C ND2 1 
ATOM   5382 N  N   . LYS C 1 135 ? 43.585  12.697  -42.931 1.00 13.86 ? 135 LYS C N   1 
ATOM   5383 C  CA  . LYS C 1 135 ? 44.138  12.685  -44.250 1.00 14.75 ? 135 LYS C CA  1 
ATOM   5384 C  C   . LYS C 1 135 ? 44.006  11.342  -44.966 1.00 12.87 ? 135 LYS C C   1 
ATOM   5385 O  O   . LYS C 1 135 ? 43.794  10.292  -44.310 1.00 12.33 ? 135 LYS C O   1 
ATOM   5386 C  CB  . LYS C 1 135 ? 45.641  13.070  -44.199 1.00 15.35 ? 135 LYS C CB  1 
ATOM   5387 C  CG  . LYS C 1 135 ? 45.810  14.537  -43.719 1.00 16.95 ? 135 LYS C CG  1 
ATOM   5388 C  CD  . LYS C 1 135 ? 47.241  15.079  -43.678 1.00 18.56 ? 135 LYS C CD  1 
ATOM   5389 C  CE  . LYS C 1 135 ? 47.307  16.473  -43.057 1.00 17.83 ? 135 LYS C CE  1 
ATOM   5390 N  NZ  . LYS C 1 135 ? 46.687  16.569  -41.705 1.00 18.00 ? 135 LYS C NZ  1 
ATOM   5391 N  N   . SER C 1 136 ? 44.118  11.362  -46.277 1.00 14.12 ? 136 SER C N   1 
ATOM   5392 C  CA  . SER C 1 136 ? 43.966  10.231  -47.091 1.00 12.61 ? 136 SER C CA  1 
ATOM   5393 C  C   . SER C 1 136 ? 44.823  9.055   -46.639 1.00 12.39 ? 136 SER C C   1 
ATOM   5394 O  O   . SER C 1 136 ? 46.050  9.184   -46.413 1.00 13.69 ? 136 SER C O   1 
ATOM   5395 C  CB  . SER C 1 136 ? 44.410  10.683  -48.489 1.00 16.02 ? 136 SER C CB  1 
ATOM   5396 O  OG  . SER C 1 136 ? 44.442  9.555   -49.265 1.00 19.85 ? 136 SER C OG  1 
ATOM   5397 N  N   . GLU C 1 137 ? 44.186  7.912   -46.481 1.00 12.30 ? 137 GLU C N   1 
ATOM   5398 C  CA  . GLU C 1 137 ? 44.934  6.695   -46.110 1.00 11.87 ? 137 GLU C CA  1 
ATOM   5399 C  C   . GLU C 1 137 ? 45.633  6.848   -44.812 1.00 11.14 ? 137 GLU C C   1 
ATOM   5400 O  O   . GLU C 1 137 ? 46.638  6.130   -44.554 1.00 10.83 ? 137 GLU C O   1 
ATOM   5401 C  CB  . GLU C 1 137 ? 45.915  6.199   -47.208 1.00 12.62 ? 137 GLU C CB  1 
ATOM   5402 C  CG  . GLU C 1 137 ? 45.201  5.982   -48.556 1.00 18.86 ? 137 GLU C CG  1 
ATOM   5403 C  CD  . GLU C 1 137 ? 46.130  5.491   -49.696 1.00 24.86 ? 137 GLU C CD  1 
ATOM   5404 O  OE1 . GLU C 1 137 ? 45.532  4.888   -50.627 1.00 32.38 ? 137 GLU C OE1 1 
ATOM   5405 O  OE2 . GLU C 1 137 ? 47.401  5.604   -49.670 1.00 31.82 ? 137 GLU C OE2 1 
ATOM   5406 N  N   . GLY C 1 138 ? 45.109  7.627   -43.903 1.00 8.84  ? 138 GLY C N   1 
ATOM   5407 C  CA  . GLY C 1 138 ? 45.818  7.998   -42.698 1.00 8.34  ? 138 GLY C CA  1 
ATOM   5408 C  C   . GLY C 1 138 ? 45.950  6.951   -41.663 1.00 7.88  ? 138 GLY C C   1 
ATOM   5409 O  O   . GLY C 1 138 ? 46.890  6.929   -40.903 1.00 8.52  ? 138 GLY C O   1 
ATOM   5410 N  N   . LEU C 1 139 ? 44.878  6.153   -41.458 1.00 7.65  ? 139 LEU C N   1 
ATOM   5411 C  CA  . LEU C 1 139 ? 44.820  5.285   -40.291 1.00 7.85  ? 139 LEU C CA  1 
ATOM   5412 C  C   . LEU C 1 139 ? 44.476  3.842   -40.643 1.00 6.93  ? 139 LEU C C   1 
ATOM   5413 O  O   . LEU C 1 139 ? 43.848  3.600   -41.695 1.00 7.80  ? 139 LEU C O   1 
ATOM   5414 C  CB  . LEU C 1 139 ? 43.759  5.760   -39.296 1.00 8.14  ? 139 LEU C CB  1 
ATOM   5415 C  CG  . LEU C 1 139 ? 43.993  7.173   -38.772 1.00 7.88  ? 139 LEU C CG  1 
ATOM   5416 C  CD1 . LEU C 1 139 ? 42.723  7.663   -38.047 1.00 11.00 ? 139 LEU C CD1 1 
ATOM   5417 C  CD2 . LEU C 1 139 ? 45.238  7.258   -37.898 1.00 10.47 ? 139 LEU C CD2 1 
ATOM   5418 N  N   . ALA C 1 140 ? 44.879  2.901   -39.813 1.00 6.34  ? 140 ALA C N   1 
ATOM   5419 C  CA  . ALA C 1 140 ? 44.487  1.503   -39.954 1.00 7.29  ? 140 ALA C CA  1 
ATOM   5420 C  C   . ALA C 1 140 ? 44.213  1.038   -38.530 1.00 7.41  ? 140 ALA C C   1 
ATOM   5421 O  O   . ALA C 1 140 ? 44.976  1.237   -37.636 1.00 8.38  ? 140 ALA C O   1 
ATOM   5422 C  CB  . ALA C 1 140 ? 45.531  0.587   -40.590 1.00 8.28  ? 140 ALA C CB  1 
ATOM   5423 N  N   . VAL C 1 141 ? 43.026  0.424   -38.299 1.00 6.55  ? 141 VAL C N   1 
ATOM   5424 C  CA  . VAL C 1 141 ? 42.638  -0.023  -36.966 1.00 6.29  ? 141 VAL C CA  1 
ATOM   5425 C  C   . VAL C 1 141 ? 42.455  -1.516  -37.035 1.00 6.13  ? 141 VAL C C   1 
ATOM   5426 O  O   . VAL C 1 141 ? 41.765  -2.042  -37.969 1.00 7.15  ? 141 VAL C O   1 
ATOM   5427 C  CB  . VAL C 1 141 ? 41.392  0.681   -36.420 1.00 6.57  ? 141 VAL C CB  1 
ATOM   5428 C  CG1 . VAL C 1 141 ? 41.060  0.162   -35.003 1.00 8.43  ? 141 VAL C CG1 1 
ATOM   5429 C  CG2 . VAL C 1 141 ? 41.625  2.214   -36.413 1.00 8.11  ? 141 VAL C CG2 1 
ATOM   5430 N  N   . LEU C 1 142 ? 43.022  -2.248  -36.066 1.00 6.15  ? 142 LEU C N   1 
ATOM   5431 C  CA  . LEU C 1 142 ? 42.721  -3.649  -35.905 1.00 7.26  ? 142 LEU C CA  1 
ATOM   5432 C  C   . LEU C 1 142 ? 41.682  -3.788  -34.850 1.00 7.20  ? 142 LEU C C   1 
ATOM   5433 O  O   . LEU C 1 142 ? 41.840  -3.172  -33.757 1.00 8.31  ? 142 LEU C O   1 
ATOM   5434 C  CB  . LEU C 1 142 ? 43.961  -4.417  -35.410 1.00 8.87  ? 142 LEU C CB  1 
ATOM   5435 C  CG  . LEU C 1 142 ? 45.216  -4.238  -36.257 1.00 9.49  ? 142 LEU C CG  1 
ATOM   5436 C  CD1 . LEU C 1 142 ? 46.334  -5.057  -35.659 1.00 11.99 ? 142 LEU C CD1 1 
ATOM   5437 C  CD2 . LEU C 1 142 ? 45.023  -4.761  -37.656 1.00 11.02 ? 142 LEU C CD2 1 
ATOM   5438 N  N   . ALA C 1 143 ? 40.640  -4.547  -35.107 1.00 6.41  ? 143 ALA C N   1 
ATOM   5439 C  CA  . ALA C 1 143 ? 39.551  -4.755  -34.143 1.00 6.71  ? 143 ALA C CA  1 
ATOM   5440 C  C   . ALA C 1 143 ? 39.441  -6.224  -33.791 1.00 6.33  ? 143 ALA C C   1 
ATOM   5441 O  O   . ALA C 1 143 ? 39.401  -7.120  -34.608 1.00 7.52  ? 143 ALA C O   1 
ATOM   5442 C  CB  . ALA C 1 143 ? 38.230  -4.315  -34.746 1.00 8.27  ? 143 ALA C CB  1 
ATOM   5443 N  N   . VAL C 1 144 ? 39.419  -6.382  -32.472 1.00 7.34  ? 144 VAL C N   1 
ATOM   5444 C  CA  . VAL C 1 144 ? 39.244  -7.709  -31.890 1.00 8.37  ? 144 VAL C CA  1 
ATOM   5445 C  C   . VAL C 1 144 ? 37.891  -7.721  -31.112 1.00 8.29  ? 144 VAL C C   1 
ATOM   5446 O  O   . VAL C 1 144 ? 37.653  -6.901  -30.213 1.00 8.25  ? 144 VAL C O   1 
ATOM   5447 C  CB  . VAL C 1 144 ? 40.353  -7.991  -30.872 1.00 8.88  ? 144 VAL C CB  1 
ATOM   5448 C  CG1 . VAL C 1 144 ? 40.101  -9.448  -30.313 1.00 10.17 ? 144 VAL C CG1 1 
ATOM   5449 C  CG2 . VAL C 1 144 ? 41.731  -7.936  -31.557 1.00 9.63  ? 144 VAL C CG2 1 
ATOM   5450 N  N   . LEU C 1 145 ? 37.032  -8.685  -31.508 1.00 8.88  ? 145 LEU C N   1 
ATOM   5451 C  CA  . LEU C 1 145 ? 35.762  -8.858  -30.815 1.00 9.19  ? 145 LEU C CA  1 
ATOM   5452 C  C   . LEU C 1 145 ? 36.012  -9.714  -29.531 1.00 10.32 ? 145 LEU C C   1 
ATOM   5453 O  O   . LEU C 1 145 ? 36.756  -10.676 -29.600 1.00 11.40 ? 145 LEU C O   1 
ATOM   5454 C  CB  . LEU C 1 145 ? 34.738  -9.526  -31.718 1.00 10.56 ? 145 LEU C CB  1 
ATOM   5455 C  CG  . LEU C 1 145 ? 34.552  -8.776  -33.038 1.00 10.65 ? 145 LEU C CG  1 
ATOM   5456 C  CD1 . LEU C 1 145 ? 33.935  -9.691  -34.102 1.00 12.88 ? 145 LEU C CD1 1 
ATOM   5457 C  CD2 . LEU C 1 145 ? 33.765  -7.515  -32.719 1.00 13.76 ? 145 LEU C CD2 1 
ATOM   5458 N  N   . ILE C 1 146 ? 35.337  -9.257  -28.487 1.00 8.30  ? 146 ILE C N   1 
ATOM   5459 C  CA  . ILE C 1 146 ? 35.534  -9.864  -27.127 1.00 10.11 ? 146 ILE C CA  1 
ATOM   5460 C  C   . ILE C 1 146 ? 34.237  -10.489 -26.653 1.00 11.67 ? 146 ILE C C   1 
ATOM   5461 O  O   . ILE C 1 146 ? 33.220  -9.835  -26.650 1.00 10.75 ? 146 ILE C O   1 
ATOM   5462 C  CB  . ILE C 1 146 ? 36.036  -8.830  -26.112 1.00 9.51  ? 146 ILE C CB  1 
ATOM   5463 C  CG1 . ILE C 1 146 ? 37.421  -8.226  -26.538 1.00 11.41 ? 146 ILE C CG1 1 
ATOM   5464 C  CG2 . ILE C 1 146 ? 36.124  -9.501  -24.690 1.00 10.97 ? 146 ILE C CG2 1 
ATOM   5465 C  CD1 . ILE C 1 146 ? 37.835  -6.987  -25.804 1.00 12.06 ? 146 ILE C CD1 1 
ATOM   5466 N  N   . GLU C 1 147 ? 34.292  -11.786 -26.274 1.00 12.95 ? 147 GLU C N   1 
ATOM   5467 C  CA  . GLU C 1 147 ? 33.093  -12.444 -25.637 1.00 14.10 ? 147 GLU C CA  1 
ATOM   5468 C  C   . GLU C 1 147 ? 33.480  -12.963 -24.268 1.00 15.61 ? 147 GLU C C   1 
ATOM   5469 O  O   . GLU C 1 147 ? 34.642  -13.146 -23.989 1.00 16.44 ? 147 GLU C O   1 
ATOM   5470 C  CB  . GLU C 1 147 ? 32.585  -13.550 -26.541 1.00 16.04 ? 147 GLU C CB  1 
ATOM   5471 C  CG  . GLU C 1 147 ? 33.589  -14.674 -26.756 1.00 18.37 ? 147 GLU C CG  1 
ATOM   5472 C  CD  . GLU C 1 147 ? 33.139  -15.647 -27.832 1.00 24.92 ? 147 GLU C CD  1 
ATOM   5473 O  OE1 . GLU C 1 147 ? 32.098  -15.376 -28.514 1.00 25.64 ? 147 GLU C OE1 1 
ATOM   5474 O  OE2 . GLU C 1 147 ? 33.832  -16.690 -28.008 1.00 28.08 ? 147 GLU C OE2 1 
ATOM   5475 N  N   . MET C 1 148 ? 32.478  -13.194 -23.426 1.00 17.93 ? 148 MET C N   1 
ATOM   5476 C  CA  . MET C 1 148 ? 32.703  -13.966 -22.169 1.00 20.61 ? 148 MET C CA  1 
ATOM   5477 C  C   . MET C 1 148 ? 33.137  -15.427 -22.384 1.00 21.19 ? 148 MET C C   1 
ATOM   5478 O  O   . MET C 1 148 ? 32.690  -16.174 -23.267 1.00 20.46 ? 148 MET C O   1 
ATOM   5479 C  CB  . MET C 1 148 ? 31.418  -14.012 -21.349 1.00 25.33 ? 148 MET C CB  1 
ATOM   5480 C  CG  . MET C 1 148 ? 30.956  -12.766 -20.596 1.00 32.97 ? 148 MET C CG  1 
ATOM   5481 S  SD  . MET C 1 148 ? 30.093  -13.166 -18.976 1.00 53.50 ? 148 MET C SD  1 
ATOM   5482 C  CE  . MET C 1 148 ? 29.001  -14.563 -19.381 1.00 38.23 ? 148 MET C CE  1 
ATOM   5483 N  N   . GLY C 1 149 ? 34.062  -15.857 -21.538 1.00 20.44 ? 149 GLY C N   1 
ATOM   5484 C  CA  . GLY C 1 149 ? 34.533  -17.241 -21.612 1.00 21.49 ? 149 GLY C CA  1 
ATOM   5485 C  C   . GLY C 1 149 ? 35.608  -17.370 -20.536 1.00 19.39 ? 149 GLY C C   1 
ATOM   5486 O  O   . GLY C 1 149 ? 35.427  -16.889 -19.389 1.00 21.69 ? 149 GLY C O   1 
ATOM   5487 N  N   . SER C 1 150 ? 36.727  -17.939 -20.953 1.00 21.88 ? 150 SER C N   1 
ATOM   5488 C  CA  . SER C 1 150 ? 37.863  -18.118 -20.057 1.00 20.72 ? 150 SER C CA  1 
ATOM   5489 C  C   . SER C 1 150 ? 38.567  -16.880 -19.664 1.00 24.17 ? 150 SER C C   1 
ATOM   5490 O  O   . SER C 1 150 ? 38.654  -15.927 -20.452 1.00 19.73 ? 150 SER C O   1 
ATOM   5491 C  CB  . SER C 1 150 ? 38.919  -18.991 -20.715 1.00 28.42 ? 150 SER C CB  1 
ATOM   5492 O  OG  . SER C 1 150 ? 38.467  -20.323 -20.825 1.00 35.47 ? 150 SER C OG  1 
ATOM   5493 N  N   . PHE C 1 151 ? 39.131  -16.902 -18.457 1.00 23.07 ? 151 PHE C N   1 
ATOM   5494 C  CA  . PHE C 1 151 ? 39.969  -15.819 -17.996 1.00 21.08 ? 151 PHE C CA  1 
ATOM   5495 C  C   . PHE C 1 151 ? 41.119  -15.629 -18.973 1.00 22.65 ? 151 PHE C C   1 
ATOM   5496 O  O   . PHE C 1 151 ? 41.699  -16.597 -19.438 1.00 23.87 ? 151 PHE C O   1 
ATOM   5497 C  CB  . PHE C 1 151 ? 40.582  -16.229 -16.602 1.00 19.65 ? 151 PHE C CB  1 
ATOM   5498 C  CG  . PHE C 1 151 ? 41.584  -15.225 -16.086 1.00 20.04 ? 151 PHE C CG  1 
ATOM   5499 C  CD1 . PHE C 1 151 ? 41.137  -14.036 -15.586 1.00 16.99 ? 151 PHE C CD1 1 
ATOM   5500 C  CD2 . PHE C 1 151 ? 42.971  -15.471 -16.111 1.00 19.98 ? 151 PHE C CD2 1 
ATOM   5501 C  CE1 . PHE C 1 151 ? 41.997  -13.026 -15.126 1.00 20.07 ? 151 PHE C CE1 1 
ATOM   5502 C  CE2 . PHE C 1 151 ? 43.808  -14.491 -15.631 1.00 18.88 ? 151 PHE C CE2 1 
ATOM   5503 C  CZ  . PHE C 1 151 ? 43.348  -13.270 -15.137 1.00 20.78 ? 151 PHE C CZ  1 
ATOM   5504 N  N   . ASN C 1 152 ? 41.461  -14.364 -19.231 1.00 21.08 ? 152 ASN C N   1 
ATOM   5505 C  CA  . ASN C 1 152 ? 42.523  -14.032 -20.143 1.00 19.79 ? 152 ASN C CA  1 
ATOM   5506 C  C   . ASN C 1 152 ? 43.645  -13.249 -19.495 1.00 17.27 ? 152 ASN C C   1 
ATOM   5507 O  O   . ASN C 1 152 ? 43.533  -12.096 -19.135 1.00 18.98 ? 152 ASN C O   1 
ATOM   5508 C  CB  . ASN C 1 152 ? 41.878  -13.202 -21.292 1.00 18.50 ? 152 ASN C CB  1 
ATOM   5509 C  CG  . ASN C 1 152 ? 42.782  -13.057 -22.458 1.00 21.83 ? 152 ASN C CG  1 
ATOM   5510 O  OD1 . ASN C 1 152 ? 43.967  -12.678 -22.299 1.00 18.42 ? 152 ASN C OD1 1 
ATOM   5511 N  ND2 . ASN C 1 152 ? 42.245  -13.326 -23.678 1.00 18.38 ? 152 ASN C ND2 1 
ATOM   5512 N  N   . PRO C 1 153 ? 44.743  -13.936 -19.192 1.00 22.12 ? 153 PRO C N   1 
ATOM   5513 C  CA  . PRO C 1 153 ? 45.853  -13.343 -18.503 1.00 22.23 ? 153 PRO C CA  1 
ATOM   5514 C  C   . PRO C 1 153 ? 46.440  -12.122 -19.257 1.00 19.93 ? 153 PRO C C   1 
ATOM   5515 O  O   . PRO C 1 153 ? 46.811  -11.153 -18.646 1.00 20.68 ? 153 PRO C O   1 
ATOM   5516 C  CB  . PRO C 1 153 ? 46.891  -14.522 -18.414 1.00 21.91 ? 153 PRO C CB  1 
ATOM   5517 C  CG  . PRO C 1 153 ? 46.131  -15.753 -18.737 1.00 25.59 ? 153 PRO C CG  1 
ATOM   5518 C  CD  . PRO C 1 153 ? 44.897  -15.367 -19.519 1.00 17.58 ? 153 PRO C CD  1 
ATOM   5519 N  N   . SER C 1 154 ? 46.377  -12.118 -20.598 1.00 21.10 ? 154 SER C N   1 
ATOM   5520 C  CA  . SER C 1 154 ? 46.883  -10.939 -21.394 1.00 18.65 ? 154 SER C CA  1 
ATOM   5521 C  C   . SER C 1 154 ? 46.061  -9.698  -21.282 1.00 15.48 ? 154 SER C C   1 
ATOM   5522 O  O   . SER C 1 154 ? 46.579  -8.593  -21.066 1.00 17.09 ? 154 SER C O   1 
ATOM   5523 C  CB  . SER C 1 154 ? 47.104  -11.351 -22.856 1.00 21.64 ? 154 SER C CB  1 
ATOM   5524 O  OG  . SER C 1 154 ? 47.706  -12.658 -22.846 1.00 28.53 ? 154 SER C OG  1 
ATOM   5525 N  N   . TYR C 1 155 ? 44.707  -9.832  -21.350 1.00 15.93 ? 155 TYR C N   1 
ATOM   5526 C  CA  . TYR C 1 155 ? 43.894  -8.745  -21.081 1.00 15.99 ? 155 TYR C CA  1 
ATOM   5527 C  C   . TYR C 1 155 ? 44.051  -8.216  -19.677 1.00 14.61 ? 155 TYR C C   1 
ATOM   5528 O  O   . TYR C 1 155 ? 43.937  -6.948  -19.411 1.00 15.33 ? 155 TYR C O   1 
ATOM   5529 C  CB  . TYR C 1 155 ? 42.390  -8.979  -21.469 1.00 13.08 ? 155 TYR C CB  1 
ATOM   5530 C  CG  . TYR C 1 155 ? 42.195  -8.849  -23.007 1.00 13.42 ? 155 TYR C CG  1 
ATOM   5531 C  CD1 . TYR C 1 155 ? 41.594  -7.686  -23.512 1.00 13.65 ? 155 TYR C CD1 1 
ATOM   5532 C  CD2 . TYR C 1 155 ? 42.675  -9.817  -23.885 1.00 13.36 ? 155 TYR C CD2 1 
ATOM   5533 C  CE1 . TYR C 1 155 ? 41.378  -7.589  -24.899 1.00 12.88 ? 155 TYR C CE1 1 
ATOM   5534 C  CE2 . TYR C 1 155 ? 42.479  -9.701  -25.308 1.00 13.19 ? 155 TYR C CE2 1 
ATOM   5535 C  CZ  . TYR C 1 155 ? 41.875  -8.537  -25.735 1.00 13.10 ? 155 TYR C CZ  1 
ATOM   5536 O  OH  . TYR C 1 155 ? 41.719  -8.414  -27.094 1.00 13.95 ? 155 TYR C OH  1 
ATOM   5537 N  N   . ASP C 1 156 ? 44.333  -9.152  -18.746 1.00 18.31 ? 156 ASP C N   1 
ATOM   5538 C  CA  . ASP C 1 156 ? 44.513  -8.702  -17.392 1.00 21.00 ? 156 ASP C CA  1 
ATOM   5539 C  C   . ASP C 1 156 ? 45.780  -7.840  -17.170 1.00 17.54 ? 156 ASP C C   1 
ATOM   5540 O  O   . ASP C 1 156 ? 45.836  -7.140  -16.139 1.00 18.06 ? 156 ASP C O   1 
ATOM   5541 C  CB  . ASP C 1 156 ? 44.444  -9.825  -16.384 1.00 21.36 ? 156 ASP C CB  1 
ATOM   5542 C  CG  . ASP C 1 156 ? 43.364  -9.599  -15.343 1.00 26.39 ? 156 ASP C CG  1 
ATOM   5543 O  OD1 . ASP C 1 156 ? 42.265  -9.140  -15.721 1.00 19.82 ? 156 ASP C OD1 1 
ATOM   5544 O  OD2 . ASP C 1 156 ? 43.615  -9.867  -14.148 1.00 30.18 ? 156 ASP C OD2 1 
ATOM   5545 N  N   . LYS C 1 157 ? 46.715  -7.879  -18.149 1.00 19.27 ? 157 LYS C N   1 
ATOM   5546 C  CA  . LYS C 1 157 ? 47.823  -6.926  -18.182 1.00 21.01 ? 157 LYS C CA  1 
ATOM   5547 C  C   . LYS C 1 157 ? 47.371  -5.443  -18.274 1.00 23.90 ? 157 LYS C C   1 
ATOM   5548 O  O   . LYS C 1 157 ? 48.026  -4.579  -17.743 1.00 25.32 ? 157 LYS C O   1 
ATOM   5549 C  CB  . LYS C 1 157 ? 48.842  -7.323  -19.220 1.00 22.20 ? 157 LYS C CB  1 
ATOM   5550 C  CG  . LYS C 1 157 ? 49.453  -8.665  -18.870 1.00 23.49 ? 157 LYS C CG  1 
ATOM   5551 C  CD  . LYS C 1 157 ? 50.457  -9.158  -19.870 1.00 26.91 ? 157 LYS C CD  1 
ATOM   5552 C  CE  . LYS C 1 157 ? 50.732  -10.610 -19.556 1.00 30.92 ? 157 LYS C CE  1 
ATOM   5553 N  NZ  . LYS C 1 157 ? 51.579  -11.212 -20.597 1.00 29.14 ? 157 LYS C NZ  1 
ATOM   5554 N  N   . ILE C 1 158 ? 46.222  -5.173  -18.895 1.00 17.85 ? 158 ILE C N   1 
ATOM   5555 C  CA  . ILE C 1 158 ? 45.703  -3.863  -18.892 1.00 17.62 ? 158 ILE C CA  1 
ATOM   5556 C  C   . ILE C 1 158 ? 44.750  -3.747  -17.700 1.00 16.89 ? 158 ILE C C   1 
ATOM   5557 O  O   . ILE C 1 158 ? 44.744  -2.676  -17.074 1.00 18.44 ? 158 ILE C O   1 
ATOM   5558 C  CB  . ILE C 1 158 ? 44.891  -3.619  -20.226 1.00 16.45 ? 158 ILE C CB  1 
ATOM   5559 C  CG1 . ILE C 1 158 ? 45.837  -3.801  -21.402 1.00 21.69 ? 158 ILE C CG1 1 
ATOM   5560 C  CG2 . ILE C 1 158 ? 44.190  -2.265  -20.261 1.00 16.78 ? 158 ILE C CG2 1 
ATOM   5561 C  CD1 . ILE C 1 158 ? 45.151  -3.860  -22.764 1.00 24.56 ? 158 ILE C CD1 1 
ATOM   5562 N  N   . PHE C 1 159 ? 43.799  -4.698  -17.555 1.00 17.25 ? 159 PHE C N   1 
ATOM   5563 C  CA  . PHE C 1 159 ? 42.672  -4.472  -16.637 1.00 18.74 ? 159 PHE C CA  1 
ATOM   5564 C  C   . PHE C 1 159 ? 43.043  -4.245  -15.163 1.00 17.28 ? 159 PHE C C   1 
ATOM   5565 O  O   . PHE C 1 159 ? 42.311  -3.597  -14.396 1.00 19.04 ? 159 PHE C O   1 
ATOM   5566 C  CB  . PHE C 1 159 ? 41.635  -5.594  -16.724 1.00 16.96 ? 159 PHE C CB  1 
ATOM   5567 C  CG  . PHE C 1 159 ? 40.954  -5.776  -18.066 1.00 17.90 ? 159 PHE C CG  1 
ATOM   5568 C  CD1 . PHE C 1 159 ? 40.836  -4.753  -18.998 1.00 20.38 ? 159 PHE C CD1 1 
ATOM   5569 C  CD2 . PHE C 1 159 ? 40.380  -7.001  -18.363 1.00 16.74 ? 159 PHE C CD2 1 
ATOM   5570 C  CE1 . PHE C 1 159 ? 40.185  -4.972  -20.209 1.00 18.38 ? 159 PHE C CE1 1 
ATOM   5571 C  CE2 . PHE C 1 159 ? 39.733  -7.225  -19.563 1.00 19.08 ? 159 PHE C CE2 1 
ATOM   5572 C  CZ  . PHE C 1 159 ? 39.634  -6.209  -20.489 1.00 17.16 ? 159 PHE C CZ  1 
ATOM   5573 N  N   . SER C 1 160 ? 44.188  -4.804  -14.839 1.00 20.87 ? 160 SER C N   1 
ATOM   5574 C  CA  . SER C 1 160 ? 44.753  -4.737  -13.474 1.00 19.14 ? 160 SER C CA  1 
ATOM   5575 C  C   . SER C 1 160 ? 45.243  -3.375  -13.127 1.00 24.06 ? 160 SER C C   1 
ATOM   5576 O  O   . SER C 1 160 ? 45.602  -3.109  -11.979 1.00 23.79 ? 160 SER C O   1 
ATOM   5577 C  CB  . SER C 1 160 ? 45.833  -5.811  -13.309 1.00 19.61 ? 160 SER C CB  1 
ATOM   5578 O  OG  . SER C 1 160 ? 46.969  -5.616  -14.143 1.00 21.48 ? 160 SER C OG  1 
ATOM   5579 N  N   . HIS C 1 161 ? 45.284  -2.463  -14.078 1.00 18.26 ? 161 HIS C N   1 
ATOM   5580 C  CA  . HIS C 1 161 ? 45.567  -1.072  -13.756 1.00 19.11 ? 161 HIS C CA  1 
ATOM   5581 C  C   . HIS C 1 161 ? 44.462  -0.096  -13.753 1.00 18.88 ? 161 HIS C C   1 
ATOM   5582 O  O   . HIS C 1 161 ? 44.667  1.094   -13.532 1.00 18.01 ? 161 HIS C O   1 
ATOM   5583 C  CB  . HIS C 1 161 ? 46.685  -0.558  -14.690 1.00 21.40 ? 161 HIS C CB  1 
ATOM   5584 C  CG  . HIS C 1 161 ? 47.947  -1.380  -14.622 1.00 25.39 ? 161 HIS C CG  1 
ATOM   5585 N  ND1 . HIS C 1 161 ? 49.002  -1.036  -13.812 1.00 24.27 ? 161 HIS C ND1 1 
ATOM   5586 C  CD2 . HIS C 1 161 ? 48.299  -2.571  -15.247 1.00 24.43 ? 161 HIS C CD2 1 
ATOM   5587 C  CE1 . HIS C 1 161 ? 49.985  -1.944  -13.976 1.00 25.32 ? 161 HIS C CE1 1 
ATOM   5588 N  NE2 . HIS C 1 161 ? 49.553  -2.884  -14.847 1.00 29.81 ? 161 HIS C NE2 1 
ATOM   5589 N  N   . LEU C 1 162 ? 43.239  -0.562  -14.053 1.00 18.03 ? 162 LEU C N   1 
ATOM   5590 C  CA  . LEU C 1 162 ? 42.153  0.390   -14.224 1.00 18.60 ? 162 LEU C CA  1 
ATOM   5591 C  C   . LEU C 1 162 ? 41.795  1.195   -13.019 1.00 15.30 ? 162 LEU C C   1 
ATOM   5592 O  O   . LEU C 1 162 ? 41.401  2.343   -13.178 1.00 18.67 ? 162 LEU C O   1 
ATOM   5593 C  CB  . LEU C 1 162 ? 40.882  -0.292  -14.791 1.00 17.91 ? 162 LEU C CB  1 
ATOM   5594 C  CG  . LEU C 1 162 ? 41.094  -0.909  -16.218 1.00 21.98 ? 162 LEU C CG  1 
ATOM   5595 C  CD1 . LEU C 1 162 ? 39.905  -1.714  -16.740 1.00 25.61 ? 162 LEU C CD1 1 
ATOM   5596 C  CD2 . LEU C 1 162 ? 41.556  0.069   -17.305 1.00 25.12 ? 162 LEU C CD2 1 
ATOM   5597 N  N   . GLN C 1 163 ? 42.008  0.688   -11.758 1.00 17.56 ? 163 GLN C N   1 
ATOM   5598 C  CA  . GLN C 1 163 ? 41.644  1.506   -10.578 1.00 19.26 ? 163 GLN C CA  1 
ATOM   5599 C  C   . GLN C 1 163 ? 42.588  2.691   -10.372 1.00 15.94 ? 163 GLN C C   1 
ATOM   5600 O  O   . GLN C 1 163 ? 42.338  3.496   -9.506  1.00 19.69 ? 163 GLN C O   1 
ATOM   5601 C  CB  . GLN C 1 163 ? 41.678  0.674   -9.308  1.00 19.37 ? 163 GLN C CB  1 
ATOM   5602 C  CG  . GLN C 1 163 ? 40.604  -0.460  -9.177  1.00 24.21 ? 163 GLN C CG  1 
ATOM   5603 C  CD  . GLN C 1 163 ? 39.180  -0.012  -9.408  1.00 26.25 ? 163 GLN C CD  1 
ATOM   5604 O  OE1 . GLN C 1 163 ? 38.640  0.925   -8.768  1.00 27.88 ? 163 GLN C OE1 1 
ATOM   5605 N  NE2 . GLN C 1 163 ? 38.565  -0.635  -10.390 1.00 31.26 ? 163 GLN C NE2 1 
ATOM   5606 N  N   . HIS C 1 164 ? 43.682  2.765   -11.129 1.00 16.44 ? 164 HIS C N   1 
ATOM   5607 C  CA  . HIS C 1 164 ? 44.548  3.953   -11.124 1.00 15.75 ? 164 HIS C CA  1 
ATOM   5608 C  C   . HIS C 1 164 ? 44.184  5.045   -12.092 1.00 20.82 ? 164 HIS C C   1 
ATOM   5609 O  O   . HIS C 1 164 ? 44.727  6.129   -12.068 1.00 20.31 ? 164 HIS C O   1 
ATOM   5610 C  CB  . HIS C 1 164 ? 45.991  3.581   -11.347 1.00 16.80 ? 164 HIS C CB  1 
ATOM   5611 C  CG  . HIS C 1 164 ? 46.462  2.509   -10.392 1.00 16.82 ? 164 HIS C CG  1 
ATOM   5612 N  ND1 . HIS C 1 164 ? 46.538  2.728   -9.045  1.00 15.93 ? 164 HIS C ND1 1 
ATOM   5613 C  CD2 . HIS C 1 164 ? 46.791  1.175   -10.606 1.00 15.99 ? 164 HIS C CD2 1 
ATOM   5614 C  CE1 . HIS C 1 164 ? 46.877  1.564   -8.445  1.00 17.03 ? 164 HIS C CE1 1 
ATOM   5615 N  NE2 . HIS C 1 164 ? 47.045  0.617   -9.404  1.00 17.09 ? 164 HIS C NE2 1 
ATOM   5616 N  N   . VAL C 1 165 ? 43.232  4.748   -12.971 1.00 19.81 ? 165 VAL C N   1 
ATOM   5617 C  CA  . VAL C 1 165 ? 42.751  5.798   -13.852 1.00 18.85 ? 165 VAL C CA  1 
ATOM   5618 C  C   . VAL C 1 165 ? 41.248  5.878   -13.789 1.00 19.34 ? 165 VAL C C   1 
ATOM   5619 O  O   . VAL C 1 165 ? 40.562  6.088   -14.808 1.00 17.54 ? 165 VAL C O   1 
ATOM   5620 C  CB  . VAL C 1 165 ? 43.307  5.596   -15.271 1.00 19.12 ? 165 VAL C CB  1 
ATOM   5621 C  CG1 . VAL C 1 165 ? 44.822  5.812   -15.292 1.00 19.73 ? 165 VAL C CG1 1 
ATOM   5622 C  CG2 . VAL C 1 165 ? 43.045  4.207   -15.748 1.00 19.12 ? 165 VAL C CG2 1 
ATOM   5623 N  N   . LYS C 1 166 ? 40.665  5.778   -12.589 1.00 19.59 ? 166 LYS C N   1 
ATOM   5624 C  CA  . LYS C 1 166 ? 39.213  5.713   -12.528 1.00 18.54 ? 166 LYS C CA  1 
ATOM   5625 C  C   . LYS C 1 166 ? 38.542  6.970   -12.971 1.00 20.34 ? 166 LYS C C   1 
ATOM   5626 O  O   . LYS C 1 166 ? 37.330  6.984   -13.319 1.00 21.04 ? 166 LYS C O   1 
ATOM   5627 C  CB  . LYS C 1 166 ? 38.737  5.422   -11.067 1.00 21.63 ? 166 LYS C CB  1 
ATOM   5628 C  CG  . LYS C 1 166 ? 39.112  4.037   -10.571 1.00 23.62 ? 166 LYS C CG  1 
ATOM   5629 C  CD  . LYS C 1 166 ? 38.536  3.821   -9.151  1.00 23.94 ? 166 LYS C CD  1 
ATOM   5630 C  CE  . LYS C 1 166 ? 37.037  4.031   -9.079  1.00 27.58 ? 166 LYS C CE  1 
ATOM   5631 N  NZ  . LYS C 1 166 ? 36.437  2.716   -9.503  1.00 28.75 ? 166 LYS C NZ  1 
ATOM   5632 N  N   . TYR C 1 167 ? 39.246  8.082   -12.965 1.00 16.02 ? 167 TYR C N   1 
ATOM   5633 C  CA  . TYR C 1 167 ? 38.533  9.341   -13.199 1.00 16.50 ? 167 TYR C CA  1 
ATOM   5634 C  C   . TYR C 1 167 ? 39.054  10.008  -14.478 1.00 14.48 ? 167 TYR C C   1 
ATOM   5635 O  O   . TYR C 1 167 ? 40.231  9.838   -14.760 1.00 16.41 ? 167 TYR C O   1 
ATOM   5636 C  CB  . TYR C 1 167 ? 38.578  10.403  -12.067 1.00 16.62 ? 167 TYR C CB  1 
ATOM   5637 C  CG  . TYR C 1 167 ? 37.908  9.987   -10.804 1.00 23.85 ? 167 TYR C CG  1 
ATOM   5638 C  CD1 . TYR C 1 167 ? 36.537  10.168  -10.650 1.00 22.50 ? 167 TYR C CD1 1 
ATOM   5639 C  CD2 . TYR C 1 167 ? 38.659  9.453   -9.757  1.00 21.84 ? 167 TYR C CD2 1 
ATOM   5640 C  CE1 . TYR C 1 167 ? 35.914  9.777   -9.470  1.00 25.63 ? 167 TYR C CE1 1 
ATOM   5641 C  CE2 . TYR C 1 167 ? 38.055  9.038   -8.595  1.00 25.53 ? 167 TYR C CE2 1 
ATOM   5642 C  CZ  . TYR C 1 167 ? 36.679  9.217   -8.451  1.00 26.68 ? 167 TYR C CZ  1 
ATOM   5643 O  OH  . TYR C 1 167 ? 36.096  8.820   -7.246  1.00 30.42 ? 167 TYR C OH  1 
ATOM   5644 N  N   . LYS C 1 168 ? 38.220  10.846  -15.091 1.00 17.40 ? 168 LYS C N   1 
ATOM   5645 C  CA  . LYS C 1 168 ? 38.647  11.617  -16.259 1.00 18.14 ? 168 LYS C CA  1 
ATOM   5646 C  C   . LYS C 1 168 ? 39.960  12.365  -16.049 1.00 21.48 ? 168 LYS C C   1 
ATOM   5647 O  O   . LYS C 1 168 ? 40.162  13.091  -15.031 1.00 23.24 ? 168 LYS C O   1 
ATOM   5648 C  CB  . LYS C 1 168 ? 37.558  12.616  -16.712 1.00 21.08 ? 168 LYS C CB  1 
ATOM   5649 C  CG  . LYS C 1 168 ? 37.955  13.188  -18.047 1.00 18.89 ? 168 LYS C CG  1 
ATOM   5650 C  CD  . LYS C 1 168 ? 36.819  14.025  -18.588 1.00 25.02 ? 168 LYS C CD  1 
ATOM   5651 C  CE  . LYS C 1 168 ? 37.374  14.755  -19.792 1.00 28.53 ? 168 LYS C CE  1 
ATOM   5652 N  NZ  . LYS C 1 168 ? 36.303  15.537  -20.496 1.00 33.50 ? 168 LYS C NZ  1 
ATOM   5653 N  N   . GLY C 1 169 ? 40.854  12.255  -17.027 1.00 20.67 ? 169 GLY C N   1 
ATOM   5654 C  CA  . GLY C 1 169 ? 42.115  12.959  -16.934 1.00 19.86 ? 169 GLY C CA  1 
ATOM   5655 C  C   . GLY C 1 169 ? 43.223  12.220  -16.241 1.00 19.38 ? 169 GLY C C   1 
ATOM   5656 O  O   . GLY C 1 169 ? 44.419  12.608  -16.434 1.00 23.00 ? 169 GLY C O   1 
ATOM   5657 N  N   . GLN C 1 170 ? 42.906  11.165  -15.442 1.00 16.43 ? 170 GLN C N   1 
ATOM   5658 C  CA  . GLN C 1 170 ? 43.909  10.474  -14.749 1.00 16.46 ? 170 GLN C CA  1 
ATOM   5659 C  C   . GLN C 1 170 ? 44.744  9.575   -15.610 1.00 17.54 ? 170 GLN C C   1 
ATOM   5660 O  O   . GLN C 1 170 ? 44.278  9.037   -16.636 1.00 17.12 ? 170 GLN C O   1 
ATOM   5661 C  CB  . GLN C 1 170 ? 43.294  9.684   -13.572 1.00 15.97 ? 170 GLN C CB  1 
ATOM   5662 C  CG  . GLN C 1 170 ? 42.725  10.584  -12.448 1.00 18.67 ? 170 GLN C CG  1 
ATOM   5663 C  CD  . GLN C 1 170 ? 42.246  9.726   -11.261 1.00 19.69 ? 170 GLN C CD  1 
ATOM   5664 O  OE1 . GLN C 1 170 ? 41.714  8.650   -11.402 1.00 18.48 ? 170 GLN C OE1 1 
ATOM   5665 N  NE2 . GLN C 1 170 ? 42.481  10.230  -10.040 1.00 20.50 ? 170 GLN C NE2 1 
ATOM   5666 N  N   . GLU C 1 171 ? 45.995  9.449   -15.247 1.00 18.18 ? 171 GLU C N   1 
ATOM   5667 C  CA  . GLU C 1 171 ? 46.944  8.618   -15.999 1.00 16.83 ? 171 GLU C CA  1 
ATOM   5668 C  C   . GLU C 1 171 ? 47.717  7.681   -15.169 1.00 16.26 ? 171 GLU C C   1 
ATOM   5669 O  O   . GLU C 1 171 ? 47.975  7.939   -13.955 1.00 19.13 ? 171 GLU C O   1 
ATOM   5670 C  CB  . GLU C 1 171 ? 47.950  9.574   -16.684 1.00 20.86 ? 171 GLU C CB  1 
ATOM   5671 C  CG  . GLU C 1 171 ? 47.319  10.580  -17.617 1.00 24.33 ? 171 GLU C CG  1 
ATOM   5672 C  CD  . GLU C 1 171 ? 48.305  11.529  -18.270 1.00 28.40 ? 171 GLU C CD  1 
ATOM   5673 O  OE1 . GLU C 1 171 ? 49.506  11.612  -17.834 1.00 32.14 ? 171 GLU C OE1 1 
ATOM   5674 O  OE2 . GLU C 1 171 ? 47.797  12.208  -19.212 1.00 32.81 ? 171 GLU C OE2 1 
ATOM   5675 N  N   . ALA C 1 172 ? 48.190  6.631   -15.761 1.00 16.01 ? 172 ALA C N   1 
ATOM   5676 C  CA  . ALA C 1 172 ? 49.053  5.652   -15.083 1.00 16.62 ? 172 ALA C CA  1 
ATOM   5677 C  C   . ALA C 1 172 ? 49.929  4.986   -16.047 1.00 22.38 ? 172 ALA C C   1 
ATOM   5678 O  O   . ALA C 1 172 ? 49.827  5.167   -17.251 1.00 22.66 ? 172 ALA C O   1 
ATOM   5679 C  CB  . ALA C 1 172 ? 48.266  4.624   -14.260 1.00 17.45 ? 172 ALA C CB  1 
ATOM   5680 N  N   . PHE C 1 173 ? 50.873  4.231   -15.579 1.00 19.96 ? 173 PHE C N   1 
ATOM   5681 C  CA  . PHE C 1 173 ? 51.759  3.481   -16.454 1.00 20.82 ? 173 PHE C CA  1 
ATOM   5682 C  C   . PHE C 1 173 ? 51.549  2.006   -16.308 1.00 23.11 ? 173 PHE C C   1 
ATOM   5683 O  O   . PHE C 1 173 ? 51.235  1.497   -15.221 1.00 25.25 ? 173 PHE C O   1 
ATOM   5684 C  CB  . PHE C 1 173 ? 53.252  3.803   -16.288 1.00 20.63 ? 173 PHE C CB  1 
ATOM   5685 C  CG  . PHE C 1 173 ? 53.664  5.136   -16.789 1.00 19.96 ? 173 PHE C CG  1 
ATOM   5686 C  CD1 . PHE C 1 173 ? 53.925  5.313   -18.144 1.00 22.31 ? 173 PHE C CD1 1 
ATOM   5687 C  CD2 . PHE C 1 173 ? 53.870  6.210   -15.920 1.00 21.97 ? 173 PHE C CD2 1 
ATOM   5688 C  CE1 . PHE C 1 173 ? 54.342  6.525   -18.647 1.00 22.31 ? 173 PHE C CE1 1 
ATOM   5689 C  CE2 . PHE C 1 173 ? 54.271  7.448   -16.425 1.00 23.73 ? 173 PHE C CE2 1 
ATOM   5690 C  CZ  . PHE C 1 173 ? 54.514  7.606   -17.785 1.00 24.24 ? 173 PHE C CZ  1 
ATOM   5691 N  N   . VAL C 1 174 ? 51.592  1.340   -17.450 1.00 20.72 ? 174 VAL C N   1 
ATOM   5692 C  CA  . VAL C 1 174 ? 51.496  -0.127  -17.561 1.00 21.06 ? 174 VAL C CA  1 
ATOM   5693 C  C   . VAL C 1 174 ? 52.829  -0.641  -18.089 1.00 21.06 ? 174 VAL C C   1 
ATOM   5694 O  O   . VAL C 1 174 ? 53.326  -0.217  -19.109 1.00 19.36 ? 174 VAL C O   1 
ATOM   5695 C  CB  . VAL C 1 174 ? 50.420  -0.491  -18.662 1.00 19.25 ? 174 VAL C CB  1 
ATOM   5696 C  CG1 . VAL C 1 174 ? 50.447  -1.997  -18.988 1.00 19.03 ? 174 VAL C CG1 1 
ATOM   5697 C  CG2 . VAL C 1 174 ? 49.073  0.005   -18.260 1.00 21.41 ? 174 VAL C CG2 1 
ATOM   5698 N  N   . PRO C 1 175 ? 53.421  -1.649  -17.438 1.00 20.36 ? 175 PRO C N   1 
ATOM   5699 C  CA  . PRO C 1 175 ? 54.602  -2.244  -18.031 1.00 19.02 ? 175 PRO C CA  1 
ATOM   5700 C  C   . PRO C 1 175 ? 54.367  -2.919  -19.369 1.00 19.39 ? 175 PRO C C   1 
ATOM   5701 O  O   . PRO C 1 175 ? 53.276  -3.434  -19.639 1.00 19.61 ? 175 PRO C O   1 
ATOM   5702 C  CB  . PRO C 1 175 ? 55.079  -3.251  -16.966 1.00 20.48 ? 175 PRO C CB  1 
ATOM   5703 C  CG  . PRO C 1 175 ? 54.209  -2.997  -15.784 1.00 20.32 ? 175 PRO C CG  1 
ATOM   5704 C  CD  . PRO C 1 175 ? 52.952  -2.361  -16.229 1.00 19.14 ? 175 PRO C CD  1 
ATOM   5705 N  N   . GLY C 1 176 ? 55.362  -2.898  -20.221 1.00 17.60 ? 176 GLY C N   1 
ATOM   5706 C  CA  . GLY C 1 176 ? 55.322  -3.556  -21.504 1.00 17.74 ? 176 GLY C CA  1 
ATOM   5707 C  C   . GLY C 1 176 ? 54.920  -4.989  -21.409 1.00 19.93 ? 176 GLY C C   1 
ATOM   5708 O  O   . GLY C 1 176 ? 55.173  -5.641  -20.444 1.00 21.44 ? 176 GLY C O   1 
ATOM   5709 N  N   . PHE C 1 177 ? 54.209  -5.454  -22.412 1.00 16.67 ? 177 PHE C N   1 
ATOM   5710 C  CA  . PHE C 1 177 ? 53.944  -6.901  -22.625 1.00 14.61 ? 177 PHE C CA  1 
ATOM   5711 C  C   . PHE C 1 177 ? 53.734  -7.119  -24.127 1.00 18.25 ? 177 PHE C C   1 
ATOM   5712 O  O   . PHE C 1 177 ? 53.735  -6.187  -24.924 1.00 16.35 ? 177 PHE C O   1 
ATOM   5713 C  CB  . PHE C 1 177 ? 52.727  -7.361  -21.790 1.00 17.17 ? 177 PHE C CB  1 
ATOM   5714 C  CG  . PHE C 1 177 ? 51.408  -6.768  -22.223 1.00 16.63 ? 177 PHE C CG  1 
ATOM   5715 C  CD1 . PHE C 1 177 ? 50.557  -7.510  -23.022 1.00 17.87 ? 177 PHE C CD1 1 
ATOM   5716 C  CD2 . PHE C 1 177 ? 50.998  -5.508  -21.773 1.00 16.17 ? 177 PHE C CD2 1 
ATOM   5717 C  CE1 . PHE C 1 177 ? 49.344  -7.007  -23.417 1.00 16.18 ? 177 PHE C CE1 1 
ATOM   5718 C  CE2 . PHE C 1 177 ? 49.761  -5.006  -22.124 1.00 18.46 ? 177 PHE C CE2 1 
ATOM   5719 C  CZ  . PHE C 1 177 ? 48.970  -5.758  -22.980 1.00 16.53 ? 177 PHE C CZ  1 
ATOM   5720 N  N   . ASN C 1 178 ? 53.591  -8.367  -24.530 1.00 16.60 ? 178 ASN C N   1 
ATOM   5721 C  CA  . ASN C 1 178 ? 53.413  -8.667  -25.944 1.00 17.16 ? 178 ASN C CA  1 
ATOM   5722 C  C   . ASN C 1 178 ? 51.938  -8.397  -26.389 1.00 15.70 ? 178 ASN C C   1 
ATOM   5723 O  O   . ASN C 1 178 ? 50.970  -9.074  -26.017 1.00 16.20 ? 178 ASN C O   1 
ATOM   5724 C  CB  . ASN C 1 178 ? 53.832  -10.110 -26.217 1.00 18.71 ? 178 ASN C CB  1 
ATOM   5725 C  CG  . ASN C 1 178 ? 53.670  -10.482 -27.644 1.00 22.11 ? 178 ASN C CG  1 
ATOM   5726 O  OD1 . ASN C 1 178 ? 53.428  -9.615  -28.480 1.00 18.91 ? 178 ASN C OD1 1 
ATOM   5727 N  ND2 . ASN C 1 178 ? 53.789  -11.786 -27.959 1.00 22.74 ? 178 ASN C ND2 1 
ATOM   5728 N  N   . ILE C 1 179 ? 51.804  -7.275  -27.129 1.00 15.22 ? 179 ILE C N   1 
ATOM   5729 C  CA  . ILE C 1 179 ? 50.493  -6.899  -27.551 1.00 14.73 ? 179 ILE C CA  1 
ATOM   5730 C  C   . ILE C 1 179 ? 49.857  -7.918  -28.493 1.00 15.05 ? 179 ILE C C   1 
ATOM   5731 O  O   . ILE C 1 179 ? 48.605  -8.006  -28.551 1.00 14.56 ? 179 ILE C O   1 
ATOM   5732 C  CB  . ILE C 1 179 ? 50.603  -5.527  -28.231 1.00 14.92 ? 179 ILE C CB  1 
ATOM   5733 C  CG1 . ILE C 1 179 ? 51.228  -4.467  -27.315 1.00 15.92 ? 179 ILE C CG1 1 
ATOM   5734 C  CG2 . ILE C 1 179 ? 49.214  -5.122  -28.790 1.00 15.68 ? 179 ILE C CG2 1 
ATOM   5735 C  CD1 . ILE C 1 179 ? 50.407  -4.233  -26.016 1.00 17.20 ? 179 ILE C CD1 1 
ATOM   5736 N  N   . GLU C 1 180 ? 50.633  -8.718  -29.183 1.00 16.12 ? 180 GLU C N   1 
ATOM   5737 C  CA  . GLU C 1 180 ? 50.066  -9.760  -30.024 1.00 18.62 ? 180 GLU C CA  1 
ATOM   5738 C  C   . GLU C 1 180 ? 49.232  -10.776 -29.214 1.00 19.41 ? 180 GLU C C   1 
ATOM   5739 O  O   . GLU C 1 180 ? 48.384  -11.427 -29.749 1.00 18.10 ? 180 GLU C O   1 
ATOM   5740 C  CB  . GLU C 1 180 ? 51.152  -10.503 -30.751 1.00 19.52 ? 180 GLU C CB  1 
ATOM   5741 C  CG  . GLU C 1 180 ? 50.591  -11.078 -32.022 1.00 21.68 ? 180 GLU C CG  1 
ATOM   5742 C  CD  . GLU C 1 180 ? 51.603  -11.714 -32.949 1.00 26.21 ? 180 GLU C CD  1 
ATOM   5743 O  OE1 . GLU C 1 180 ? 52.778  -11.377 -32.737 1.00 24.01 ? 180 GLU C OE1 1 
ATOM   5744 O  OE2 . GLU C 1 180 ? 51.146  -12.518 -33.848 1.00 27.10 ? 180 GLU C OE2 1 
ATOM   5745 N  N   . GLU C 1 181 ? 49.499  -10.897 -27.901 1.00 16.29 ? 181 GLU C N   1 
ATOM   5746 C  CA  . GLU C 1 181 ? 48.686  -11.819 -27.106 1.00 16.30 ? 181 GLU C CA  1 
ATOM   5747 C  C   . GLU C 1 181 ? 47.219  -11.371 -26.989 1.00 17.76 ? 181 GLU C C   1 
ATOM   5748 O  O   . GLU C 1 181 ? 46.393  -12.195 -26.535 1.00 17.37 ? 181 GLU C O   1 
ATOM   5749 C  CB  . GLU C 1 181 ? 49.208  -12.059 -25.690 1.00 18.64 ? 181 GLU C CB  1 
ATOM   5750 C  CG  . GLU C 1 181 ? 50.623  -12.600 -25.558 1.00 22.81 ? 181 GLU C CG  1 
ATOM   5751 C  CD  . GLU C 1 181 ? 51.237  -12.310 -24.145 1.00 27.80 ? 181 GLU C CD  1 
ATOM   5752 O  OE1 . GLU C 1 181 ? 50.558  -11.769 -23.224 1.00 30.47 ? 181 GLU C OE1 1 
ATOM   5753 O  OE2 . GLU C 1 181 ? 52.454  -12.588 -23.924 1.00 33.11 ? 181 GLU C OE2 1 
ATOM   5754 N  N   . LEU C 1 182 ? 46.930  -10.100 -27.357 1.00 13.61 ? 182 LEU C N   1 
ATOM   5755 C  CA  . LEU C 1 182 ? 45.566  -9.584  -27.339 1.00 12.59 ? 182 LEU C CA  1 
ATOM   5756 C  C   . LEU C 1 182 ? 44.759  -10.014 -28.583 1.00 14.03 ? 182 LEU C C   1 
ATOM   5757 O  O   . LEU C 1 182 ? 43.539  -9.841  -28.566 1.00 12.71 ? 182 LEU C O   1 
ATOM   5758 C  CB  . LEU C 1 182 ? 45.618  -8.068  -27.214 1.00 12.82 ? 182 LEU C CB  1 
ATOM   5759 C  CG  . LEU C 1 182 ? 46.203  -7.434  -25.943 1.00 12.61 ? 182 LEU C CG  1 
ATOM   5760 C  CD1 . LEU C 1 182 ? 46.160  -5.932  -25.937 1.00 13.62 ? 182 LEU C CD1 1 
ATOM   5761 C  CD2 . LEU C 1 182 ? 45.628  -7.964  -24.604 1.00 13.85 ? 182 LEU C CD2 1 
ATOM   5762 N  N   . LEU C 1 183 ? 45.426  -10.538 -29.612 1.00 13.23 ? 183 LEU C N   1 
ATOM   5763 C  CA  . LEU C 1 183 ? 44.801  -10.867 -30.869 1.00 13.09 ? 183 LEU C CA  1 
ATOM   5764 C  C   . LEU C 1 183 ? 44.214  -12.280 -30.735 1.00 14.42 ? 183 LEU C C   1 
ATOM   5765 O  O   . LEU C 1 183 ? 44.698  -13.129 -29.925 1.00 15.99 ? 183 LEU C O   1 
ATOM   5766 C  CB  . LEU C 1 183 ? 45.819  -10.793 -32.031 1.00 14.32 ? 183 LEU C CB  1 
ATOM   5767 C  CG  . LEU C 1 183 ? 46.427  -9.389  -32.107 1.00 15.41 ? 183 LEU C CG  1 
ATOM   5768 C  CD1 . LEU C 1 183 ? 47.385  -9.387  -33.262 1.00 20.21 ? 183 LEU C CD1 1 
ATOM   5769 C  CD2 . LEU C 1 183 ? 45.475  -8.242  -32.255 1.00 15.86 ? 183 LEU C CD2 1 
ATOM   5770 N  N   . PRO C 1 184 ? 43.262  -12.625 -31.541 1.00 13.21 ? 184 PRO C N   1 
ATOM   5771 C  CA  . PRO C 1 184 ? 42.618  -13.926 -31.476 1.00 15.33 ? 184 PRO C CA  1 
ATOM   5772 C  C   . PRO C 1 184 ? 43.389  -14.986 -32.242 1.00 17.65 ? 184 PRO C C   1 
ATOM   5773 O  O   . PRO C 1 184 ? 44.491  -14.709 -32.782 1.00 17.10 ? 184 PRO C O   1 
ATOM   5774 C  CB  . PRO C 1 184 ? 41.259  -13.648 -32.139 1.00 16.40 ? 184 PRO C CB  1 
ATOM   5775 C  CG  . PRO C 1 184 ? 41.596  -12.583 -33.160 1.00 15.19 ? 184 PRO C CG  1 
ATOM   5776 C  CD  . PRO C 1 184 ? 42.585  -11.707 -32.482 1.00 12.83 ? 184 PRO C CD  1 
ATOM   5777 N  N   . GLU C 1 185 ? 42.854  -16.212 -32.205 1.00 22.49 ? 185 GLU C N   1 
ATOM   5778 C  CA  . GLU C 1 185 ? 43.332  -17.272 -33.061 1.00 25.76 ? 185 GLU C CA  1 
ATOM   5779 C  C   . GLU C 1 185 ? 43.050  -16.972 -34.523 1.00 23.00 ? 185 GLU C C   1 
ATOM   5780 O  O   . GLU C 1 185 ? 42.080  -16.190 -34.865 1.00 18.58 ? 185 GLU C O   1 
ATOM   5781 C  CB  . GLU C 1 185 ? 42.646  -18.614 -32.711 1.00 31.85 ? 185 GLU C CB  1 
ATOM   5782 C  CG  . GLU C 1 185 ? 42.933  -19.096 -31.295 1.00 38.88 ? 185 GLU C CG  1 
ATOM   5783 C  CD  . GLU C 1 185 ? 44.390  -19.396 -31.038 1.00 49.12 ? 185 GLU C CD  1 
ATOM   5784 O  OE1 . GLU C 1 185 ? 45.217  -18.467 -31.164 1.00 59.39 ? 185 GLU C OE1 1 
ATOM   5785 O  OE2 . GLU C 1 185 ? 44.704  -20.556 -30.681 1.00 58.47 ? 185 GLU C OE2 1 
ATOM   5786 N  N   A ARG C 1 186 ? 43.897  -17.550 -35.376 0.50 20.37 ? 186 ARG C N   1 
ATOM   5787 N  N   B ARG C 1 186 ? 43.867  -17.591 -35.378 0.50 20.44 ? 186 ARG C N   1 
ATOM   5788 C  CA  A ARG C 1 186 ? 43.802  -17.426 -36.823 0.50 21.02 ? 186 ARG C CA  1 
ATOM   5789 C  CA  B ARG C 1 186 ? 43.832  -17.426 -36.830 0.50 21.11 ? 186 ARG C CA  1 
ATOM   5790 C  C   A ARG C 1 186 ? 43.610  -15.976 -37.301 0.50 19.00 ? 186 ARG C C   1 
ATOM   5791 C  C   B ARG C 1 186 ? 43.613  -15.979 -37.301 0.50 19.07 ? 186 ARG C C   1 
ATOM   5792 O  O   A ARG C 1 186 ? 42.653  -15.637 -38.037 0.50 19.04 ? 186 ARG C O   1 
ATOM   5793 O  O   B ARG C 1 186 ? 42.650  -15.647 -38.033 0.50 19.16 ? 186 ARG C O   1 
ATOM   5794 C  CB  A ARG C 1 186 ? 42.712  -18.332 -37.341 0.50 22.79 ? 186 ARG C CB  1 
ATOM   5795 C  CB  B ARG C 1 186 ? 42.852  -18.396 -37.452 0.50 22.97 ? 186 ARG C CB  1 
ATOM   5796 C  CG  A ARG C 1 186 ? 42.768  -19.693 -36.651 0.50 25.52 ? 186 ARG C CG  1 
ATOM   5797 C  CG  B ARG C 1 186 ? 43.150  -19.812 -36.965 0.50 25.60 ? 186 ARG C CG  1 
ATOM   5798 C  CD  A ARG C 1 186 ? 41.682  -20.615 -37.209 0.50 26.12 ? 186 ARG C CD  1 
ATOM   5799 C  CD  B ARG C 1 186 ? 41.944  -20.742 -37.063 0.50 26.61 ? 186 ARG C CD  1 
ATOM   5800 N  NE  A ARG C 1 186 ? 40.431  -20.514 -36.450 0.50 31.34 ? 186 ARG C NE  1 
ATOM   5801 N  NE  B ARG C 1 186 ? 41.007  -20.561 -35.946 0.50 31.64 ? 186 ARG C NE  1 
ATOM   5802 C  CZ  A ARG C 1 186 ? 39.286  -21.042 -36.840 0.50 30.00 ? 186 ARG C CZ  1 
ATOM   5803 C  CZ  B ARG C 1 186 ? 41.127  -21.113 -34.743 0.50 27.87 ? 186 ARG C CZ  1 
ATOM   5804 N  NH1 A ARG C 1 186 ? 39.251  -21.702 -37.995 0.50 32.32 ? 186 ARG C NH1 1 
ATOM   5805 N  NH1 B ARG C 1 186 ? 42.170  -21.872 -34.448 0.50 29.39 ? 186 ARG C NH1 1 
ATOM   5806 N  NH2 A ARG C 1 186 ? 38.189  -20.913 -36.087 0.50 29.60 ? 186 ARG C NH2 1 
ATOM   5807 N  NH2 B ARG C 1 186 ? 40.215  -20.863 -33.817 0.50 29.88 ? 186 ARG C NH2 1 
ATOM   5808 N  N   . THR C 1 187 ? 44.566  -15.145 -36.939 1.00 16.37 ? 187 THR C N   1 
ATOM   5809 C  CA  . THR C 1 187 ? 44.566  -13.787 -37.438 1.00 14.38 ? 187 THR C CA  1 
ATOM   5810 C  C   . THR C 1 187 ? 44.537  -13.683 -38.927 1.00 13.79 ? 187 THR C C   1 
ATOM   5811 O  O   . THR C 1 187 ? 44.212  -12.633 -39.395 1.00 12.33 ? 187 THR C O   1 
ATOM   5812 C  CB  . THR C 1 187 ? 45.646  -12.904 -36.842 1.00 15.80 ? 187 THR C CB  1 
ATOM   5813 O  OG1 . THR C 1 187 ? 46.890  -13.563 -37.002 1.00 18.80 ? 187 THR C OG1 1 
ATOM   5814 C  CG2 . THR C 1 187 ? 45.439  -12.722 -35.361 1.00 17.65 ? 187 THR C CG2 1 
ATOM   5815 N  N   . ALA C 1 188 ? 44.898  -14.740 -39.660 1.00 13.66 ? 188 ALA C N   1 
ATOM   5816 C  CA  . ALA C 1 188 ? 44.758  -14.678 -41.111 1.00 12.64 ? 188 ALA C CA  1 
ATOM   5817 C  C   . ALA C 1 188 ? 43.300  -14.509 -41.542 1.00 11.27 ? 188 ALA C C   1 
ATOM   5818 O  O   . ALA C 1 188 ? 43.092  -14.143 -42.703 1.00 11.86 ? 188 ALA C O   1 
ATOM   5819 C  CB  . ALA C 1 188 ? 45.301  -15.956 -41.761 1.00 15.80 ? 188 ALA C CB  1 
ATOM   5820 N  N   . GLU C 1 189 ? 42.288  -14.786 -40.682 1.00 12.85 ? 189 GLU C N   1 
ATOM   5821 C  CA  . GLU C 1 189 ? 40.858  -14.718 -41.099 1.00 12.01 ? 189 GLU C CA  1 
ATOM   5822 C  C   . GLU C 1 189 ? 40.317  -13.380 -40.562 1.00 9.56  ? 189 GLU C C   1 
ATOM   5823 O  O   . GLU C 1 189 ? 40.317  -13.105 -39.363 1.00 9.77  ? 189 GLU C O   1 
ATOM   5824 C  CB  . GLU C 1 189 ? 39.992  -15.813 -40.477 1.00 15.72 ? 189 GLU C CB  1 
ATOM   5825 C  CG  . GLU C 1 189 ? 40.504  -17.207 -40.920 1.00 19.38 ? 189 GLU C CG  1 
ATOM   5826 C  CD  . GLU C 1 189 ? 39.965  -18.376 -40.071 1.00 26.70 ? 189 GLU C CD  1 
ATOM   5827 O  OE1 . GLU C 1 189 ? 39.112  -18.157 -39.181 1.00 29.90 ? 189 GLU C OE1 1 
ATOM   5828 O  OE2 . GLU C 1 189 ? 40.431  -19.558 -40.261 1.00 33.34 ? 189 GLU C OE2 1 
ATOM   5829 N  N   . TYR C 1 190 ? 39.968  -12.514 -41.498 1.00 8.35  ? 190 TYR C N   1 
ATOM   5830 C  CA  . TYR C 1 190 ? 39.491  -11.170 -41.072 1.00 8.51  ? 190 TYR C CA  1 
ATOM   5831 C  C   . TYR C 1 190 ? 38.578  -10.601 -42.147 1.00 7.90  ? 190 TYR C C   1 
ATOM   5832 O  O   . TYR C 1 190 ? 38.605  -10.968 -43.287 1.00 8.40  ? 190 TYR C O   1 
ATOM   5833 C  CB  . TYR C 1 190 ? 40.666  -10.206 -40.801 1.00 9.14  ? 190 TYR C CB  1 
ATOM   5834 C  CG  . TYR C 1 190 ? 41.643  -10.027 -41.957 1.00 9.50  ? 190 TYR C CG  1 
ATOM   5835 C  CD1 . TYR C 1 190 ? 41.419  -9.085  -42.989 1.00 9.33  ? 190 TYR C CD1 1 
ATOM   5836 C  CD2 . TYR C 1 190 ? 42.849  -10.786 -41.980 1.00 9.84  ? 190 TYR C CD2 1 
ATOM   5837 C  CE1 . TYR C 1 190 ? 42.363  -8.862  -44.053 1.00 9.42  ? 190 TYR C CE1 1 
ATOM   5838 C  CE2 . TYR C 1 190 ? 43.752  -10.546 -43.006 1.00 9.01  ? 190 TYR C CE2 1 
ATOM   5839 C  CZ  . TYR C 1 190 ? 43.489  -9.657  -44.038 1.00 9.48  ? 190 TYR C CZ  1 
ATOM   5840 O  OH  . TYR C 1 190 ? 44.406  -9.418  -45.015 1.00 10.13 ? 190 TYR C OH  1 
ATOM   5841 N  N   . TYR C 1 191 ? 37.828  -9.562  -41.698 1.00 7.01  ? 191 TYR C N   1 
ATOM   5842 C  CA  . TYR C 1 191 ? 37.004  -8.757  -42.540 1.00 6.34  ? 191 TYR C CA  1 
ATOM   5843 C  C   . TYR C 1 191 ? 37.766  -7.448  -42.781 1.00 6.60  ? 191 TYR C C   1 
ATOM   5844 O  O   . TYR C 1 191 ? 38.502  -6.980  -41.863 1.00 7.69  ? 191 TYR C O   1 
ATOM   5845 C  CB  . TYR C 1 191 ? 35.754  -8.371  -41.792 1.00 7.65  ? 191 TYR C CB  1 
ATOM   5846 C  CG  . TYR C 1 191 ? 34.865  -9.472  -41.258 1.00 8.11  ? 191 TYR C CG  1 
ATOM   5847 C  CD1 . TYR C 1 191 ? 33.828  -10.006 -42.014 1.00 9.01  ? 191 TYR C CD1 1 
ATOM   5848 C  CD2 . TYR C 1 191 ? 35.011  -9.917  -39.951 1.00 8.89  ? 191 TYR C CD2 1 
ATOM   5849 C  CE1 . TYR C 1 191 ? 32.992  -10.991 -41.500 1.00 9.22  ? 191 TYR C CE1 1 
ATOM   5850 C  CE2 . TYR C 1 191 ? 34.186  -10.897 -39.432 1.00 8.71  ? 191 TYR C CE2 1 
ATOM   5851 C  CZ  . TYR C 1 191 ? 33.182  -11.430 -40.208 1.00 9.74  ? 191 TYR C CZ  1 
ATOM   5852 O  OH  . TYR C 1 191 ? 32.368  -12.407 -39.676 1.00 13.64 ? 191 TYR C OH  1 
ATOM   5853 N  N   . ARG C 1 192 ? 37.591  -6.855  -43.964 1.00 6.57  ? 192 ARG C N   1 
ATOM   5854 C  CA  . ARG C 1 192 ? 38.287  -5.610  -44.290 1.00 7.23  ? 192 ARG C CA  1 
ATOM   5855 C  C   . ARG C 1 192 ? 37.346  -4.673  -44.951 1.00 6.31  ? 192 ARG C C   1 
ATOM   5856 O  O   . ARG C 1 192 ? 36.610  -5.050  -45.901 1.00 7.04  ? 192 ARG C O   1 
ATOM   5857 C  CB  . ARG C 1 192 ? 39.444  -5.944  -45.237 1.00 8.11  ? 192 ARG C CB  1 
ATOM   5858 C  CG  . ARG C 1 192 ? 40.057  -4.798  -46.042 1.00 8.77  ? 192 ARG C CG  1 
ATOM   5859 C  CD  . ARG C 1 192 ? 40.815  -3.804  -45.155 1.00 9.92  ? 192 ARG C CD  1 
ATOM   5860 N  NE  . ARG C 1 192 ? 41.788  -4.461  -44.289 1.00 9.23  ? 192 ARG C NE  1 
ATOM   5861 C  CZ  . ARG C 1 192 ? 42.952  -5.029  -44.645 1.00 10.20 ? 192 ARG C CZ  1 
ATOM   5862 N  NH1 . ARG C 1 192 ? 43.340  -5.021  -45.954 1.00 11.60 ? 192 ARG C NH1 1 
ATOM   5863 N  NH2 . ARG C 1 192 ? 43.724  -5.610  -43.727 1.00 11.67 ? 192 ARG C NH2 1 
ATOM   5864 N  N   . TYR C 1 193 ? 37.359  -3.419  -44.552 1.00 5.50  ? 193 TYR C N   1 
ATOM   5865 C  CA  . TYR C 1 193 ? 36.565  -2.402  -45.344 1.00 5.23  ? 193 TYR C CA  1 
ATOM   5866 C  C   . TYR C 1 193 ? 37.172  -1.036  -45.037 1.00 5.23  ? 193 TYR C C   1 
ATOM   5867 O  O   . TYR C 1 193 ? 37.810  -0.847  -43.981 1.00 5.73  ? 193 TYR C O   1 
ATOM   5868 C  CB  . TYR C 1 193 ? 35.061  -2.470  -45.019 1.00 5.19  ? 193 TYR C CB  1 
ATOM   5869 C  CG  . TYR C 1 193 ? 34.676  -1.954  -43.637 1.00 5.30  ? 193 TYR C CG  1 
ATOM   5870 C  CD1 . TYR C 1 193 ? 34.180  -0.656  -43.535 1.00 5.07  ? 193 TYR C CD1 1 
ATOM   5871 C  CD2 . TYR C 1 193 ? 34.846  -2.701  -42.494 1.00 5.09  ? 193 TYR C CD2 1 
ATOM   5872 C  CE1 . TYR C 1 193 ? 33.793  -0.151  -42.325 1.00 5.80  ? 193 TYR C CE1 1 
ATOM   5873 C  CE2 . TYR C 1 193 ? 34.502  -2.211  -41.230 1.00 5.23  ? 193 TYR C CE2 1 
ATOM   5874 C  CZ  . TYR C 1 193 ? 33.980  -0.911  -41.158 1.00 4.91  ? 193 TYR C CZ  1 
ATOM   5875 O  OH  . TYR C 1 193 ? 33.648  -0.358  -39.949 1.00 5.64  ? 193 TYR C OH  1 
ATOM   5876 N  N   . ARG C 1 194 ? 36.874  -0.099  -45.925 1.00 6.05  ? 194 ARG C N   1 
ATOM   5877 C  CA  . ARG C 1 194 ? 37.220  1.307   -45.660 1.00 6.67  ? 194 ARG C CA  1 
ATOM   5878 C  C   . ARG C 1 194 ? 36.159  2.018   -44.919 1.00 7.00  ? 194 ARG C C   1 
ATOM   5879 O  O   . ARG C 1 194 ? 34.968  2.018   -45.276 1.00 7.24  ? 194 ARG C O   1 
ATOM   5880 C  CB  . ARG C 1 194 ? 37.427  2.053   -47.029 1.00 9.80  ? 194 ARG C CB  1 
ATOM   5881 C  CG  . ARG C 1 194 ? 38.649  1.493   -47.756 1.00 14.38 ? 194 ARG C CG  1 
ATOM   5882 C  CD  . ARG C 1 194 ? 38.994  2.059   -49.167 1.00 25.70 ? 194 ARG C CD  1 
ATOM   5883 N  NE  . ARG C 1 194 ? 40.239  1.352   -49.583 1.00 35.96 ? 194 ARG C NE  1 
ATOM   5884 C  CZ  . ARG C 1 194 ? 41.503  1.680   -49.231 1.00 46.92 ? 194 ARG C CZ  1 
ATOM   5885 N  NH1 . ARG C 1 194 ? 41.780  2.761   -48.470 1.00 42.93 ? 194 ARG C NH1 1 
ATOM   5886 N  NH2 . ARG C 1 194 ? 42.517  0.907   -49.638 1.00 46.48 ? 194 ARG C NH2 1 
ATOM   5887 N  N   . GLY C 1 195 ? 36.519  2.608   -43.789 1.00 5.53  ? 195 GLY C N   1 
ATOM   5888 C  CA  . GLY C 1 195 ? 35.541  3.301   -42.998 1.00 5.70  ? 195 GLY C CA  1 
ATOM   5889 C  C   . GLY C 1 195 ? 36.119  4.477   -42.257 1.00 5.56  ? 195 GLY C C   1 
ATOM   5890 O  O   . GLY C 1 195 ? 36.918  5.253   -42.807 1.00 5.97  ? 195 GLY C O   1 
ATOM   5891 N  N   . SER C 1 196 ? 35.632  4.712   -41.046 1.00 5.37  ? 196 SER C N   1 
ATOM   5892 C  CA  . SER C 1 196 ? 35.932  5.978   -40.322 1.00 5.20  ? 196 SER C CA  1 
ATOM   5893 C  C   . SER C 1 196 ? 36.313  5.674   -38.916 1.00 5.53  ? 196 SER C C   1 
ATOM   5894 O  O   . SER C 1 196 ? 36.154  4.576   -38.388 1.00 5.38  ? 196 SER C O   1 
ATOM   5895 C  CB  . SER C 1 196 ? 34.680  6.878   -40.306 1.00 6.10  ? 196 SER C CB  1 
ATOM   5896 O  OG  . SER C 1 196 ? 33.714  6.423   -39.390 1.00 5.59  ? 196 SER C OG  1 
ATOM   5897 N  N   . LEU C 1 197 ? 36.848  6.732   -38.315 1.00 5.33  ? 197 LEU C N   1 
ATOM   5898 C  CA  . LEU C 1 197 ? 36.898  6.734   -36.865 1.00 6.63  ? 197 LEU C CA  1 
ATOM   5899 C  C   . LEU C 1 197 ? 35.450  6.551   -36.324 1.00 5.99  ? 197 LEU C C   1 
ATOM   5900 O  O   . LEU C 1 197 ? 34.479  7.064   -36.900 1.00 6.21  ? 197 LEU C O   1 
ATOM   5901 C  CB  . LEU C 1 197 ? 37.462  8.079   -36.253 1.00 7.96  ? 197 LEU C CB  1 
ATOM   5902 C  CG  . LEU C 1 197 ? 38.926  8.216   -36.657 1.00 9.38  ? 197 LEU C CG  1 
ATOM   5903 C  CD1 . LEU C 1 197 ? 39.265  9.674   -36.281 1.00 11.36 ? 197 LEU C CD1 1 
ATOM   5904 C  CD2 . LEU C 1 197 ? 39.814  7.240   -35.985 1.00 12.22 ? 197 LEU C CD2 1 
ATOM   5905 N  N   . THR C 1 198 ? 35.338  5.854   -35.172 1.00 6.33  ? 198 THR C N   1 
ATOM   5906 C  CA  . THR C 1 198 ? 34.012  5.687   -34.546 1.00 6.25  ? 198 THR C CA  1 
ATOM   5907 C  C   . THR C 1 198 ? 33.714  6.719   -33.459 1.00 7.54  ? 198 THR C C   1 
ATOM   5908 O  O   . THR C 1 198 ? 32.650  6.690   -32.813 1.00 7.89  ? 198 THR C O   1 
ATOM   5909 C  CB  . THR C 1 198 ? 33.771  4.278   -34.037 1.00 6.71  ? 198 THR C CB  1 
ATOM   5910 O  OG1 . THR C 1 198 ? 34.624  4.116   -32.905 1.00 6.39  ? 198 THR C OG1 1 
ATOM   5911 C  CG2 . THR C 1 198 ? 34.006  3.179   -35.028 1.00 6.92  ? 198 THR C CG2 1 
ATOM   5912 N  N   . THR C 1 199 ? 34.627  7.657   -33.286 1.00 7.06  ? 199 THR C N   1 
ATOM   5913 C  CA  . THR C 1 199 ? 34.497  8.755   -32.370 1.00 7.17  ? 199 THR C CA  1 
ATOM   5914 C  C   . THR C 1 199 ? 34.779  10.012  -33.126 1.00 6.77  ? 199 THR C C   1 
ATOM   5915 O  O   . THR C 1 199 ? 35.428  9.959   -34.155 1.00 7.03  ? 199 THR C O   1 
ATOM   5916 C  CB  . THR C 1 199 ? 35.475  8.732   -31.208 1.00 8.82  ? 199 THR C CB  1 
ATOM   5917 O  OG1 . THR C 1 199 ? 36.816  8.724   -31.718 1.00 12.84 ? 199 THR C OG1 1 
ATOM   5918 C  CG2 . THR C 1 199 ? 35.294  7.438   -30.385 1.00 11.11 ? 199 THR C CG2 1 
ATOM   5919 N  N   . PRO C 1 200 ? 34.304  11.172  -32.631 1.00 7.04  ? 200 PRO C N   1 
ATOM   5920 C  CA  . PRO C 1 200 ? 34.723  12.441  -33.257 1.00 7.75  ? 200 PRO C CA  1 
ATOM   5921 C  C   . PRO C 1 200 ? 36.270  12.503  -33.417 1.00 7.98  ? 200 PRO C C   1 
ATOM   5922 O  O   . PRO C 1 200 ? 36.942  11.981  -32.500 1.00 9.06  ? 200 PRO C O   1 
ATOM   5923 C  CB  . PRO C 1 200 ? 34.263  13.474  -32.189 1.00 7.68  ? 200 PRO C CB  1 
ATOM   5924 C  CG  . PRO C 1 200 ? 32.965  12.851  -31.654 1.00 7.49  ? 200 PRO C CG  1 
ATOM   5925 C  CD  . PRO C 1 200 ? 33.343  11.368  -31.517 1.00 7.40  ? 200 PRO C CD  1 
ATOM   5926 N  N   . PRO C 1 201 ? 36.756  13.006  -34.505 1.00 7.49  ? 201 PRO C N   1 
ATOM   5927 C  CA  . PRO C 1 201 ? 36.010  13.712  -35.554 1.00 7.58  ? 201 PRO C CA  1 
ATOM   5928 C  C   . PRO C 1 201 ? 35.374  12.914  -36.666 1.00 6.30  ? 201 PRO C C   1 
ATOM   5929 O  O   . PRO C 1 201 ? 34.907  13.416  -37.648 1.00 7.90  ? 201 PRO C O   1 
ATOM   5930 C  CB  . PRO C 1 201 ? 37.031  14.726  -36.189 1.00 7.78  ? 201 PRO C CB  1 
ATOM   5931 C  CG  . PRO C 1 201 ? 38.161  14.678  -35.170 1.00 9.59  ? 201 PRO C CG  1 
ATOM   5932 C  CD  . PRO C 1 201 ? 38.232  13.279  -34.616 1.00 8.11  ? 201 PRO C CD  1 
ATOM   5933 N  N   . CYS C 1 202 ? 35.450  11.584  -36.495 1.00 6.93  ? 202 CYS C N   1 
ATOM   5934 C  CA  . CYS C 1 202 ? 34.749  10.617  -37.389 1.00 7.10  ? 202 CYS C CA  1 
ATOM   5935 C  C   . CYS C 1 202 ? 35.334  10.649  -38.798 1.00 6.81  ? 202 CYS C C   1 
ATOM   5936 O  O   . CYS C 1 202 ? 34.628  10.346  -39.724 1.00 7.14  ? 202 CYS C O   1 
ATOM   5937 C  CB  . CYS C 1 202 ? 33.221  10.867  -37.507 1.00 8.53  ? 202 CYS C CB  1 
ATOM   5938 S  SG  . CYS C 1 202 ? 32.305  10.815  -35.933 1.00 8.13  ? 202 CYS C SG  1 
ATOM   5939 N  N   . ASN C 1 203 ? 36.637  10.951  -38.953 1.00 7.38  ? 203 ASN C N   1 
ATOM   5940 C  CA  . ASN C 1 203 ? 37.177  11.081  -40.286 1.00 7.44  ? 203 ASN C CA  1 
ATOM   5941 C  C   . ASN C 1 203 ? 37.119  9.797   -41.032 1.00 6.86  ? 203 ASN C C   1 
ATOM   5942 O  O   . ASN C 1 203 ? 37.414  8.734   -40.425 1.00 6.37  ? 203 ASN C O   1 
ATOM   5943 C  CB  . ASN C 1 203 ? 38.648  11.514  -40.156 1.00 8.12  ? 203 ASN C CB  1 
ATOM   5944 C  CG  . ASN C 1 203 ? 38.768  12.785  -39.338 1.00 8.96  ? 203 ASN C CG  1 
ATOM   5945 O  OD1 . ASN C 1 203 ? 38.839  12.682  -38.121 1.00 10.34 ? 203 ASN C OD1 1 
ATOM   5946 N  ND2 . ASN C 1 203 ? 38.699  13.912  -39.956 1.00 12.08 ? 203 ASN C ND2 1 
ATOM   5947 N  N   . PRO C 1 204 ? 36.781  9.852   -42.313 1.00 6.99  ? 204 PRO C N   1 
ATOM   5948 C  CA  . PRO C 1 204 ? 36.635  8.595   -43.149 1.00 6.98  ? 204 PRO C CA  1 
ATOM   5949 C  C   . PRO C 1 204 ? 37.977  8.183   -43.691 1.00 7.30  ? 204 PRO C C   1 
ATOM   5950 O  O   . PRO C 1 204 ? 38.148  8.010   -44.914 1.00 9.23  ? 204 PRO C O   1 
ATOM   5951 C  CB  . PRO C 1 204 ? 35.699  9.051   -44.258 1.00 8.15  ? 204 PRO C CB  1 
ATOM   5952 C  CG  . PRO C 1 204 ? 36.023  10.553  -44.446 1.00 8.75  ? 204 PRO C CG  1 
ATOM   5953 C  CD  . PRO C 1 204 ? 36.318  11.094  -43.066 1.00 8.10  ? 204 PRO C CD  1 
ATOM   5954 N  N   . THR C 1 205 ? 38.884  7.894   -42.754 1.00 6.90  ? 205 THR C N   1 
ATOM   5955 C  CA  . THR C 1 205 ? 40.310  7.724   -43.120 1.00 7.93  ? 205 THR C CA  1 
ATOM   5956 C  C   . THR C 1 205 ? 40.850  6.440   -42.539 1.00 8.23  ? 205 THR C C   1 
ATOM   5957 O  O   . THR C 1 205 ? 42.085  6.204   -42.536 1.00 9.28  ? 205 THR C O   1 
ATOM   5958 C  CB  . THR C 1 205 ? 41.137  8.859   -42.525 1.00 7.79  ? 205 THR C CB  1 
ATOM   5959 O  OG1 . THR C 1 205 ? 40.868  8.916   -41.138 1.00 9.40  ? 205 THR C OG1 1 
ATOM   5960 C  CG2 . THR C 1 205 ? 40.796  10.177  -43.288 1.00 9.30  ? 205 THR C CG2 1 
ATOM   5961 N  N   . VAL C 1 206 ? 39.970  5.494   -42.157 1.00 6.82  ? 206 VAL C N   1 
ATOM   5962 C  CA  . VAL C 1 206 ? 40.405  4.256   -41.505 1.00 6.74  ? 206 VAL C CA  1 
ATOM   5963 C  C   . VAL C 1 206 ? 40.240  3.059   -42.409 1.00 6.62  ? 206 VAL C C   1 
ATOM   5964 O  O   . VAL C 1 206 ? 39.130  2.747   -42.903 1.00 7.98  ? 206 VAL C O   1 
ATOM   5965 C  CB  . VAL C 1 206 ? 39.575  4.017   -40.245 1.00 6.02  ? 206 VAL C CB  1 
ATOM   5966 C  CG1 . VAL C 1 206 ? 39.965  2.662   -39.562 1.00 5.61  ? 206 VAL C CG1 1 
ATOM   5967 C  CG2 . VAL C 1 206 ? 39.787  5.122   -39.163 1.00 6.78  ? 206 VAL C CG2 1 
ATOM   5968 N  N   . LEU C 1 207 ? 41.333  2.312   -42.590 1.00 5.78  ? 207 LEU C N   1 
ATOM   5969 C  CA  . LEU C 1 207 ? 41.266  0.923   -43.090 1.00 6.45  ? 207 LEU C CA  1 
ATOM   5970 C  C   . LEU C 1 207 ? 41.003  -0.002  -41.962 1.00 5.80  ? 207 LEU C C   1 
ATOM   5971 O  O   . LEU C 1 207 ? 41.841  -0.191  -41.079 1.00 6.03  ? 207 LEU C O   1 
ATOM   5972 C  CB  . LEU C 1 207 ? 42.615  0.598   -43.767 1.00 9.29  ? 207 LEU C CB  1 
ATOM   5973 C  CG  . LEU C 1 207 ? 42.546  -0.652  -44.616 1.00 12.45 ? 207 LEU C CG  1 
ATOM   5974 C  CD1 . LEU C 1 207 ? 41.585  -0.561  -45.829 1.00 15.82 ? 207 LEU C CD1 1 
ATOM   5975 C  CD2 . LEU C 1 207 ? 43.977  -0.889  -45.089 1.00 19.74 ? 207 LEU C CD2 1 
ATOM   5976 N  N   . TRP C 1 208 ? 39.821  -0.601  -41.945 1.00 5.17  ? 208 TRP C N   1 
ATOM   5977 C  CA  . TRP C 1 208 ? 39.444  -1.484  -40.835 1.00 4.89  ? 208 TRP C CA  1 
ATOM   5978 C  C   . TRP C 1 208 ? 39.766  -2.910  -41.114 1.00 5.65  ? 208 TRP C C   1 
ATOM   5979 O  O   . TRP C 1 208 ? 39.567  -3.413  -42.248 1.00 6.25  ? 208 TRP C O   1 
ATOM   5980 C  CB  . TRP C 1 208 ? 37.888  -1.428  -40.598 1.00 5.08  ? 208 TRP C CB  1 
ATOM   5981 C  CG  . TRP C 1 208 ? 37.491  -0.232  -39.817 1.00 5.02  ? 208 TRP C CG  1 
ATOM   5982 C  CD1 . TRP C 1 208 ? 37.046  0.967   -40.279 1.00 4.69  ? 208 TRP C CD1 1 
ATOM   5983 C  CD2 . TRP C 1 208 ? 37.594  -0.082  -38.404 1.00 4.78  ? 208 TRP C CD2 1 
ATOM   5984 N  NE1 . TRP C 1 208 ? 36.811  1.832   -39.259 1.00 4.92  ? 208 TRP C NE1 1 
ATOM   5985 C  CE2 . TRP C 1 208 ? 37.157  1.230   -38.080 1.00 5.46  ? 208 TRP C CE2 1 
ATOM   5986 C  CE3 . TRP C 1 208 ? 37.952  -0.943  -37.377 1.00 6.10  ? 208 TRP C CE3 1 
ATOM   5987 C  CZ2 . TRP C 1 208 ? 37.122  1.716   -36.781 1.00 6.21  ? 208 TRP C CZ2 1 
ATOM   5988 C  CZ3 . TRP C 1 208 ? 37.912  -0.471  -36.092 1.00 6.37  ? 208 TRP C CZ3 1 
ATOM   5989 C  CH2 . TRP C 1 208 ? 37.525  0.841   -35.783 1.00 6.55  ? 208 TRP C CH2 1 
ATOM   5990 N  N   . THR C 1 209 ? 40.288  -3.588  -40.101 1.00 5.83  ? 209 THR C N   1 
ATOM   5991 C  CA  . THR C 1 209 ? 40.571  -5.027  -40.115 1.00 6.34  ? 209 THR C CA  1 
ATOM   5992 C  C   . THR C 1 209 ? 39.880  -5.573  -38.899 1.00 6.92  ? 209 THR C C   1 
ATOM   5993 O  O   . THR C 1 209 ? 40.359  -5.216  -37.791 1.00 7.84  ? 209 THR C O   1 
ATOM   5994 C  CB  . THR C 1 209 ? 42.074  -5.375  -40.100 1.00 7.09  ? 209 THR C CB  1 
ATOM   5995 O  OG1 . THR C 1 209 ? 42.620  -4.790  -41.281 1.00 7.56  ? 209 THR C OG1 1 
ATOM   5996 C  CG2 . THR C 1 209 ? 42.242  -6.874  -40.056 1.00 7.51  ? 209 THR C CG2 1 
ATOM   5997 N  N   . VAL C 1 210 ? 38.811  -6.350  -39.041 1.00 6.68  ? 210 VAL C N   1 
ATOM   5998 C  CA  . VAL C 1 210 ? 38.147  -6.925  -37.873 1.00 6.80  ? 210 VAL C CA  1 
ATOM   5999 C  C   . VAL C 1 210 ? 38.386  -8.404  -37.915 1.00 7.17  ? 210 VAL C C   1 
ATOM   6000 O  O   . VAL C 1 210 ? 38.007  -9.044  -38.898 1.00 7.35  ? 210 VAL C O   1 
ATOM   6001 C  CB  . VAL C 1 210 ? 36.626  -6.673  -37.968 1.00 6.96  ? 210 VAL C CB  1 
ATOM   6002 C  CG1 . VAL C 1 210 ? 35.866  -7.286  -36.806 1.00 9.08  ? 210 VAL C CG1 1 
ATOM   6003 C  CG2 . VAL C 1 210 ? 36.333  -5.182  -38.112 1.00 7.97  ? 210 VAL C CG2 1 
ATOM   6004 N  N   . PHE C 1 211 ? 39.046  -8.939  -36.907 1.00 6.85  ? 211 PHE C N   1 
ATOM   6005 C  CA  . PHE C 1 211 ? 39.313  -10.370 -36.994 1.00 7.44  ? 211 PHE C CA  1 
ATOM   6006 C  C   . PHE C 1 211 ? 38.049  -11.180 -36.929 1.00 8.54  ? 211 PHE C C   1 
ATOM   6007 O  O   . PHE C 1 211 ? 37.108  -10.823 -36.188 1.00 9.16  ? 211 PHE C O   1 
ATOM   6008 C  CB  . PHE C 1 211 ? 40.335  -10.691 -35.877 1.00 8.12  ? 211 PHE C CB  1 
ATOM   6009 C  CG  . PHE C 1 211 ? 41.645  -10.086 -36.160 1.00 7.40  ? 211 PHE C CG  1 
ATOM   6010 C  CD1 . PHE C 1 211 ? 42.425  -10.549 -37.230 1.00 9.47  ? 211 PHE C CD1 1 
ATOM   6011 C  CD2 . PHE C 1 211 ? 42.135  -9.024  -35.361 1.00 8.89  ? 211 PHE C CD2 1 
ATOM   6012 C  CE1 . PHE C 1 211 ? 43.687  -9.931  -37.514 1.00 9.97  ? 211 PHE C CE1 1 
ATOM   6013 C  CE2 . PHE C 1 211 ? 43.368  -8.457  -35.651 1.00 9.15  ? 211 PHE C CE2 1 
ATOM   6014 C  CZ  . PHE C 1 211 ? 44.106  -8.890  -36.727 1.00 9.97  ? 211 PHE C CZ  1 
ATOM   6015 N  N   . ARG C 1 212 ? 38.046  -12.270 -37.673 1.00 8.60  ? 212 ARG C N   1 
ATOM   6016 C  CA  . ARG C 1 212 ? 36.839  -13.133 -37.703 1.00 9.05  ? 212 ARG C CA  1 
ATOM   6017 C  C   . ARG C 1 212 ? 36.495  -13.749 -36.340 1.00 9.85  ? 212 ARG C C   1 
ATOM   6018 O  O   . ARG C 1 212 ? 35.343  -13.856 -35.954 1.00 11.41 ? 212 ARG C O   1 
ATOM   6019 C  CB  . ARG C 1 212 ? 37.067  -14.207 -38.726 1.00 10.78 ? 212 ARG C CB  1 
ATOM   6020 C  CG  . ARG C 1 212 ? 35.789  -15.046 -39.083 1.00 12.48 ? 212 ARG C CG  1 
ATOM   6021 C  CD  . ARG C 1 212 ? 36.234  -16.293 -39.793 1.00 15.53 ? 212 ARG C CD  1 
ATOM   6022 N  NE  . ARG C 1 212 ? 35.022  -16.918 -40.308 1.00 20.45 ? 212 ARG C NE  1 
ATOM   6023 C  CZ  . ARG C 1 212 ? 34.988  -17.945 -41.139 1.00 21.07 ? 212 ARG C CZ  1 
ATOM   6024 N  NH1 . ARG C 1 212 ? 36.103  -18.506 -41.566 1.00 23.40 ? 212 ARG C NH1 1 
ATOM   6025 N  NH2 . ARG C 1 212 ? 33.810  -18.412 -41.539 1.00 23.48 ? 212 ARG C NH2 1 
ATOM   6026 N  N   . ASN C 1 213 ? 37.556  -14.186 -35.641 1.00 10.95 ? 213 ASN C N   1 
ATOM   6027 C  CA  . ASN C 1 213 ? 37.353  -14.992 -34.404 1.00 11.81 ? 213 ASN C CA  1 
ATOM   6028 C  C   . ASN C 1 213 ? 37.482  -14.096 -33.194 1.00 11.22 ? 213 ASN C C   1 
ATOM   6029 O  O   . ASN C 1 213 ? 38.374  -13.238 -33.117 1.00 10.87 ? 213 ASN C O   1 
ATOM   6030 C  CB  . ASN C 1 213 ? 38.465  -16.036 -34.348 1.00 13.32 ? 213 ASN C CB  1 
ATOM   6031 C  CG  . ASN C 1 213 ? 38.450  -16.931 -35.529 1.00 16.37 ? 213 ASN C CG  1 
ATOM   6032 O  OD1 . ASN C 1 213 ? 39.484  -17.129 -36.193 1.00 20.34 ? 213 ASN C OD1 1 
ATOM   6033 N  ND2 . ASN C 1 213 ? 37.286  -17.514 -35.801 1.00 17.16 ? 213 ASN C ND2 1 
ATOM   6034 N  N   . PRO C 1 214 ? 36.588  -14.202 -32.228 1.00 11.79 ? 214 PRO C N   1 
ATOM   6035 C  CA  . PRO C 1 214 ? 36.668  -13.409 -31.020 1.00 10.62 ? 214 PRO C CA  1 
ATOM   6036 C  C   . PRO C 1 214 ? 37.700  -13.979 -30.026 1.00 12.01 ? 214 PRO C C   1 
ATOM   6037 O  O   . PRO C 1 214 ? 38.115  -15.152 -30.196 1.00 13.76 ? 214 PRO C O   1 
ATOM   6038 C  CB  . PRO C 1 214 ? 35.263  -13.551 -30.366 1.00 13.03 ? 214 PRO C CB  1 
ATOM   6039 C  CG  . PRO C 1 214 ? 34.877  -14.942 -30.869 1.00 15.39 ? 214 PRO C CG  1 
ATOM   6040 C  CD  . PRO C 1 214 ? 35.422  -15.115 -32.273 1.00 14.33 ? 214 PRO C CD  1 
ATOM   6041 N  N   . VAL C 1 215 ? 38.085  -13.106 -29.073 1.00 10.53 ? 215 VAL C N   1 
ATOM   6042 C  CA  . VAL C 1 215 ? 38.814  -13.596 -27.897 1.00 12.83 ? 215 VAL C CA  1 
ATOM   6043 C  C   . VAL C 1 215 ? 37.779  -13.737 -26.784 1.00 14.65 ? 215 VAL C C   1 
ATOM   6044 O  O   . VAL C 1 215 ? 36.684  -13.161 -26.833 1.00 14.40 ? 215 VAL C O   1 
ATOM   6045 C  CB  . VAL C 1 215 ? 39.949  -12.628 -27.483 1.00 13.30 ? 215 VAL C CB  1 
ATOM   6046 C  CG1 . VAL C 1 215 ? 41.043  -12.553 -28.563 1.00 16.07 ? 215 VAL C CG1 1 
ATOM   6047 C  CG2 . VAL C 1 215 ? 39.420  -11.279 -27.019 1.00 12.65 ? 215 VAL C CG2 1 
ATOM   6048 N  N   . GLN C 1 216 ? 38.157  -14.498 -25.728 1.00 14.63 ? 216 GLN C N   1 
ATOM   6049 C  CA  . GLN C 1 216 ? 37.374  -14.556 -24.506 1.00 15.81 ? 216 GLN C CA  1 
ATOM   6050 C  C   . GLN C 1 216 ? 38.035  -13.924 -23.329 1.00 15.00 ? 216 GLN C C   1 
ATOM   6051 O  O   . GLN C 1 216 ? 39.292  -14.015 -23.175 1.00 16.50 ? 216 GLN C O   1 
ATOM   6052 C  CB  . GLN C 1 216 ? 37.168  -16.036 -24.155 1.00 16.84 ? 216 GLN C CB  1 
ATOM   6053 C  CG  . GLN C 1 216 ? 36.438  -16.728 -25.250 1.00 19.40 ? 216 GLN C CG  1 
ATOM   6054 C  CD  . GLN C 1 216 ? 35.976  -18.070 -24.858 1.00 27.99 ? 216 GLN C CD  1 
ATOM   6055 O  OE1 . GLN C 1 216 ? 36.293  -18.559 -23.737 1.00 30.77 ? 216 GLN C OE1 1 
ATOM   6056 N  NE2 . GLN C 1 216 ? 35.260  -18.724 -25.766 1.00 28.87 ? 216 GLN C NE2 1 
ATOM   6057 N  N   . ILE C 1 217 ? 37.237  -13.289 -22.487 1.00 16.36 ? 217 ILE C N   1 
ATOM   6058 C  CA  . ILE C 1 217 ? 37.686  -12.821 -21.194 1.00 15.87 ? 217 ILE C CA  1 
ATOM   6059 C  C   . ILE C 1 217 ? 36.666  -13.377 -20.158 1.00 18.16 ? 217 ILE C C   1 
ATOM   6060 O  O   . ILE C 1 217 ? 35.559  -13.771 -20.551 1.00 18.06 ? 217 ILE C O   1 
ATOM   6061 C  CB  . ILE C 1 217 ? 37.833  -11.281 -21.063 1.00 16.10 ? 217 ILE C CB  1 
ATOM   6062 C  CG1 . ILE C 1 217 ? 36.491  -10.546 -21.208 1.00 14.56 ? 217 ILE C CG1 1 
ATOM   6063 C  CG2 . ILE C 1 217 ? 38.889  -10.809 -22.067 1.00 16.81 ? 217 ILE C CG2 1 
ATOM   6064 C  CD1 . ILE C 1 217 ? 36.531  -9.052  -20.979 1.00 16.87 ? 217 ILE C CD1 1 
ATOM   6065 N  N   . SER C 1 218 ? 37.044  -13.536 -18.880 1.00 17.87 ? 218 SER C N   1 
ATOM   6066 C  CA  . SER C 1 218 ? 36.055  -14.121 -17.965 1.00 18.98 ? 218 SER C CA  1 
ATOM   6067 C  C   . SER C 1 218 ? 34.936  -13.148 -17.698 1.00 18.76 ? 218 SER C C   1 
ATOM   6068 O  O   . SER C 1 218 ? 35.065  -11.880 -17.872 1.00 18.77 ? 218 SER C O   1 
ATOM   6069 C  CB  . SER C 1 218 ? 36.736  -14.479 -16.643 1.00 16.40 ? 218 SER C CB  1 
ATOM   6070 O  OG  . SER C 1 218 ? 37.287  -13.344 -16.005 1.00 19.60 ? 218 SER C OG  1 
ATOM   6071 N  N   . GLN C 1 219 ? 33.810  -13.707 -17.163 1.00 20.09 ? 219 GLN C N   1 
ATOM   6072 C  CA  . GLN C 1 219 ? 32.759  -12.810 -16.639 1.00 20.92 ? 219 GLN C CA  1 
ATOM   6073 C  C   . GLN C 1 219 ? 33.277  -11.802 -15.620 1.00 17.49 ? 219 GLN C C   1 
ATOM   6074 O  O   . GLN C 1 219 ? 32.867  -10.693 -15.563 1.00 17.46 ? 219 GLN C O   1 
ATOM   6075 C  CB  . GLN C 1 219 ? 31.526  -13.616 -16.013 1.00 25.40 ? 219 GLN C CB  1 
ATOM   6076 C  CG  . GLN C 1 219 ? 31.807  -14.176 -14.583 1.00 37.03 ? 219 GLN C CG  1 
ATOM   6077 C  CD  . GLN C 1 219 ? 30.823  -13.724 -13.449 1.00 42.38 ? 219 GLN C CD  1 
ATOM   6078 O  OE1 . GLN C 1 219 ? 29.824  -14.430 -13.182 1.00 48.48 ? 219 GLN C OE1 1 
ATOM   6079 N  NE2 . GLN C 1 219 ? 31.130  -12.583 -12.736 1.00 37.75 ? 219 GLN C NE2 1 
ATOM   6080 N  N   . GLU C 1 220 ? 34.195  -12.247 -14.749 1.00 19.00 ? 220 GLU C N   1 
ATOM   6081 C  CA  . GLU C 1 220 ? 34.757  -11.332 -13.787 1.00 20.84 ? 220 GLU C CA  1 
ATOM   6082 C  C   . GLU C 1 220 ? 35.593  -10.195 -14.430 1.00 15.39 ? 220 GLU C C   1 
ATOM   6083 O  O   . GLU C 1 220 ? 35.462  -9.124  -14.030 1.00 18.42 ? 220 GLU C O   1 
ATOM   6084 C  CB  . GLU C 1 220 ? 35.570  -12.113 -12.724 1.00 25.60 ? 220 GLU C CB  1 
ATOM   6085 C  CG  . GLU C 1 220 ? 34.849  -13.337 -12.102 1.00 33.97 ? 220 GLU C CG  1 
ATOM   6086 C  CD  . GLU C 1 220 ? 35.122  -14.725 -12.757 1.00 37.48 ? 220 GLU C CD  1 
ATOM   6087 O  OE1 . GLU C 1 220 ? 34.805  -14.998 -13.936 1.00 33.32 ? 220 GLU C OE1 1 
ATOM   6088 O  OE2 . GLU C 1 220 ? 35.641  -15.620 -12.046 1.00 40.73 ? 220 GLU C OE2 1 
ATOM   6089 N  N   . GLN C 1 221 ? 36.402  -10.515 -15.449 1.00 17.92 ? 221 GLN C N   1 
ATOM   6090 C  CA  . GLN C 1 221 ? 37.172  -9.470  -16.203 1.00 15.47 ? 221 GLN C CA  1 
ATOM   6091 C  C   . GLN C 1 221 ? 36.246  -8.447  -16.894 1.00 12.63 ? 221 GLN C C   1 
ATOM   6092 O  O   . GLN C 1 221 ? 36.421  -7.241  -16.732 1.00 14.58 ? 221 GLN C O   1 
ATOM   6093 C  CB  . GLN C 1 221 ? 38.017  -10.143 -17.222 1.00 16.33 ? 221 GLN C CB  1 
ATOM   6094 C  CG  . GLN C 1 221 ? 39.323  -10.667 -16.593 1.00 15.91 ? 221 GLN C CG  1 
ATOM   6095 C  CD  . GLN C 1 221 ? 40.129  -11.395 -17.632 1.00 15.10 ? 221 GLN C CD  1 
ATOM   6096 O  OE1 . GLN C 1 221 ? 39.703  -12.358 -18.244 1.00 14.85 ? 221 GLN C OE1 1 
ATOM   6097 N  NE2 . GLN C 1 221 ? 41.383  -10.932 -17.800 1.00 16.79 ? 221 GLN C NE2 1 
ATOM   6098 N  N   . LEU C 1 222 ? 35.139  -9.006  -17.457 1.00 15.37 ? 222 LEU C N   1 
ATOM   6099 C  CA  . LEU C 1 222 ? 34.133  -8.146  -18.129 1.00 14.83 ? 222 LEU C CA  1 
ATOM   6100 C  C   . LEU C 1 222 ? 33.428  -7.188  -17.226 1.00 13.97 ? 222 LEU C C   1 
ATOM   6101 O  O   . LEU C 1 222 ? 33.319  -6.015  -17.458 1.00 14.67 ? 222 LEU C O   1 
ATOM   6102 C  CB  . LEU C 1 222 ? 33.171  -9.011  -18.975 1.00 15.75 ? 222 LEU C CB  1 
ATOM   6103 C  CG  . LEU C 1 222 ? 32.074  -8.237  -19.692 1.00 16.88 ? 222 LEU C CG  1 
ATOM   6104 C  CD1 . LEU C 1 222 ? 32.734  -7.308  -20.726 1.00 16.89 ? 222 LEU C CD1 1 
ATOM   6105 C  CD2 . LEU C 1 222 ? 31.262  -9.310  -20.378 1.00 16.49 ? 222 LEU C CD2 1 
ATOM   6106 N  N   . LEU C 1 223 ? 32.976  -7.726  -16.055 1.00 15.47 ? 223 LEU C N   1 
ATOM   6107 C  CA  . LEU C 1 223 ? 32.348  -6.933  -15.043 1.00 17.02 ? 223 LEU C CA  1 
ATOM   6108 C  C   . LEU C 1 223 ? 33.283  -5.901  -14.475 1.00 13.61 ? 223 LEU C C   1 
ATOM   6109 O  O   . LEU C 1 223 ? 32.876  -4.781  -14.280 1.00 15.86 ? 223 LEU C O   1 
ATOM   6110 C  CB  . LEU C 1 223 ? 31.775  -7.885  -13.966 1.00 20.71 ? 223 LEU C CB  1 
ATOM   6111 C  CG  . LEU C 1 223 ? 30.815  -7.146  -13.036 1.00 22.11 ? 223 LEU C CG  1 
ATOM   6112 C  CD1 . LEU C 1 223 ? 29.570  -6.562  -13.735 1.00 23.02 ? 223 LEU C CD1 1 
ATOM   6113 C  CD2 . LEU C 1 223 ? 30.400  -8.066  -11.867 1.00 24.06 ? 223 LEU C CD2 1 
ATOM   6114 N  N   . ALA C 1 224 ? 34.521  -6.314  -14.268 1.00 19.29 ? 224 ALA C N   1 
ATOM   6115 C  CA  . ALA C 1 224 ? 35.558  -5.395  -13.824 1.00 19.95 ? 224 ALA C CA  1 
ATOM   6116 C  C   . ALA C 1 224 ? 35.720  -4.217  -14.813 1.00 16.31 ? 224 ALA C C   1 
ATOM   6117 O  O   . ALA C 1 224 ? 35.761  -3.072  -14.421 1.00 18.09 ? 224 ALA C O   1 
ATOM   6118 C  CB  . ALA C 1 224 ? 36.900  -6.147  -13.548 1.00 18.79 ? 224 ALA C CB  1 
ATOM   6119 N  N   . LEU C 1 225 ? 35.797  -4.517  -16.115 1.00 17.40 ? 225 LEU C N   1 
ATOM   6120 C  CA  . LEU C 1 225 ? 35.940  -3.413  -17.102 1.00 15.34 ? 225 LEU C CA  1 
ATOM   6121 C  C   . LEU C 1 225 ? 34.738  -2.497  -17.121 1.00 14.43 ? 225 LEU C C   1 
ATOM   6122 O  O   . LEU C 1 225 ? 34.856  -1.278  -17.094 1.00 16.34 ? 225 LEU C O   1 
ATOM   6123 C  CB  . LEU C 1 225 ? 36.119  -4.069  -18.472 1.00 14.84 ? 225 LEU C CB  1 
ATOM   6124 C  CG  . LEU C 1 225 ? 36.209  -3.066  -19.630 1.00 14.27 ? 225 LEU C CG  1 
ATOM   6125 C  CD1 . LEU C 1 225 ? 37.492  -2.269  -19.592 1.00 13.98 ? 225 LEU C CD1 1 
ATOM   6126 C  CD2 . LEU C 1 225 ? 36.218  -3.923  -20.896 1.00 16.73 ? 225 LEU C CD2 1 
ATOM   6127 N  N   . GLU C 1 226 ? 33.549  -3.114  -17.114 1.00 13.76 ? 226 GLU C N   1 
ATOM   6128 C  CA  . GLU C 1 226 ? 32.312  -2.343  -17.099 1.00 16.01 ? 226 GLU C CA  1 
ATOM   6129 C  C   . GLU C 1 226 ? 32.056  -1.472  -15.861 1.00 15.22 ? 226 GLU C C   1 
ATOM   6130 O  O   . GLU C 1 226 ? 31.300  -0.524  -15.904 1.00 18.32 ? 226 GLU C O   1 
ATOM   6131 C  CB  . GLU C 1 226 ? 31.123  -3.268  -17.275 1.00 16.91 ? 226 GLU C CB  1 
ATOM   6132 C  CG  . GLU C 1 226 ? 31.071  -4.018  -18.609 1.00 16.06 ? 226 GLU C CG  1 
ATOM   6133 C  CD  . GLU C 1 226 ? 30.192  -5.258  -18.547 1.00 18.79 ? 226 GLU C CD  1 
ATOM   6134 O  OE1 . GLU C 1 226 ? 29.903  -5.737  -17.428 1.00 16.63 ? 226 GLU C OE1 1 
ATOM   6135 O  OE2 . GLU C 1 226 ? 29.789  -5.754  -19.619 1.00 17.78 ? 226 GLU C OE2 1 
ATOM   6136 N  N   . THR C 1 227 ? 32.715  -1.847  -14.767 1.00 17.61 ? 227 THR C N   1 
ATOM   6137 C  CA  . THR C 1 227 ? 32.517  -1.186  -13.489 1.00 19.59 ? 227 THR C CA  1 
ATOM   6138 C  C   . THR C 1 227 ? 33.652  -0.321  -12.972 1.00 20.38 ? 227 THR C C   1 
ATOM   6139 O  O   . THR C 1 227 ? 33.482  0.366   -11.941 1.00 21.70 ? 227 THR C O   1 
ATOM   6140 C  CB  . THR C 1 227 ? 32.103  -2.227  -12.378 1.00 17.52 ? 227 THR C CB  1 
ATOM   6141 O  OG1 . THR C 1 227 ? 33.074  -3.255  -12.228 1.00 18.45 ? 227 THR C OG1 1 
ATOM   6142 C  CG2 . THR C 1 227 ? 30.644  -2.814  -12.687 1.00 23.26 ? 227 THR C CG2 1 
ATOM   6143 N  N   . ALA C 1 228 ? 34.762  -0.312  -13.687 1.00 17.56 ? 228 ALA C N   1 
ATOM   6144 C  CA  . ALA C 1 228 ? 35.982  0.307   -13.124 1.00 20.62 ? 228 ALA C CA  1 
ATOM   6145 C  C   . ALA C 1 228 ? 36.074  1.788   -13.238 1.00 20.30 ? 228 ALA C C   1 
ATOM   6146 O  O   . ALA C 1 228 ? 36.707  2.396   -12.388 1.00 20.13 ? 228 ALA C O   1 
ATOM   6147 C  CB  . ALA C 1 228 ? 37.205  -0.342  -13.751 1.00 20.31 ? 228 ALA C CB  1 
ATOM   6148 N  N   . LEU C 1 229 ? 35.479  2.412   -14.275 1.00 16.51 ? 229 LEU C N   1 
ATOM   6149 C  CA  . LEU C 1 229 ? 35.787  3.765   -14.687 1.00 17.13 ? 229 LEU C CA  1 
ATOM   6150 C  C   . LEU C 1 229 ? 34.665  4.705   -14.697 1.00 21.09 ? 229 LEU C C   1 
ATOM   6151 O  O   . LEU C 1 229 ? 33.467  4.351   -14.871 1.00 18.13 ? 229 LEU C O   1 
ATOM   6152 C  CB  . LEU C 1 229 ? 36.446  3.806   -16.085 1.00 19.84 ? 229 LEU C CB  1 
ATOM   6153 C  CG  . LEU C 1 229 ? 37.550  2.773   -16.268 1.00 19.55 ? 229 LEU C CG  1 
ATOM   6154 C  CD1 . LEU C 1 229 ? 37.981  2.655   -17.739 1.00 23.94 ? 229 LEU C CD1 1 
ATOM   6155 C  CD2 . LEU C 1 229 ? 38.740  3.190   -15.388 1.00 21.06 ? 229 LEU C CD2 1 
ATOM   6156 N  N   . TYR C 1 230 ? 35.041  5.952   -14.490 1.00 20.86 ? 230 TYR C N   1 
ATOM   6157 C  CA  . TYR C 1 230 ? 34.083  6.999   -14.517 1.00 19.96 ? 230 TYR C CA  1 
ATOM   6158 C  C   . TYR C 1 230 ? 34.509  7.844   -15.649 1.00 18.59 ? 230 TYR C C   1 
ATOM   6159 O  O   . TYR C 1 230 ? 35.689  7.867   -16.035 1.00 20.71 ? 230 TYR C O   1 
ATOM   6160 C  CB  . TYR C 1 230 ? 34.080  7.792   -13.179 1.00 24.02 ? 230 TYR C CB  1 
ATOM   6161 C  CG  . TYR C 1 230 ? 33.527  6.902   -12.096 1.00 31.36 ? 230 TYR C CG  1 
ATOM   6162 C  CD1 . TYR C 1 230 ? 32.199  7.050   -11.643 1.00 31.24 ? 230 TYR C CD1 1 
ATOM   6163 C  CD2 . TYR C 1 230 ? 34.286  5.815   -11.618 1.00 38.20 ? 230 TYR C CD2 1 
ATOM   6164 C  CE1 . TYR C 1 230 ? 31.692  6.192   -10.680 1.00 38.83 ? 230 TYR C CE1 1 
ATOM   6165 C  CE2 . TYR C 1 230 ? 33.778  4.933   -10.665 1.00 42.17 ? 230 TYR C CE2 1 
ATOM   6166 C  CZ  . TYR C 1 230 ? 32.489  5.122   -10.201 1.00 43.90 ? 230 TYR C CZ  1 
ATOM   6167 O  OH  . TYR C 1 230 ? 32.031  4.229   -9.255  1.00 50.32 ? 230 TYR C OH  1 
ATOM   6168 N  N   A CYS C 1 231 ? 33.532  8.536   -16.217 0.50 20.09 ? 231 CYS C N   1 
ATOM   6169 N  N   B CYS C 1 231 ? 33.558  8.612   -16.172 0.50 19.01 ? 231 CYS C N   1 
ATOM   6170 C  CA  A CYS C 1 231 ? 33.864  9.464   -17.249 0.50 21.82 ? 231 CYS C CA  1 
ATOM   6171 C  CA  B CYS C 1 231 ? 33.868  9.524   -17.255 0.50 19.75 ? 231 CYS C CA  1 
ATOM   6172 C  C   A CYS C 1 231 ? 34.376  10.724  -16.624 0.50 22.13 ? 231 CYS C C   1 
ATOM   6173 C  C   B CYS C 1 231 ? 33.943  10.972  -16.784 0.50 18.96 ? 231 CYS C C   1 
ATOM   6174 O  O   A CYS C 1 231 ? 35.320  11.301  -17.173 0.50 22.71 ? 231 CYS C O   1 
ATOM   6175 O  O   B CYS C 1 231 ? 34.219  11.922  -17.528 0.50 14.62 ? 231 CYS C O   1 
ATOM   6176 C  CB  A CYS C 1 231 ? 32.658  9.828   -18.106 0.50 21.72 ? 231 CYS C CB  1 
ATOM   6177 C  CB  B CYS C 1 231 ? 32.848  9.351   -18.375 0.50 20.18 ? 231 CYS C CB  1 
ATOM   6178 S  SG  A CYS C 1 231 ? 32.029  8.572   -19.249 0.50 24.48 ? 231 CYS C SG  1 
ATOM   6179 S  SG  B CYS C 1 231 ? 31.107  9.679   -17.990 0.50 21.99 ? 231 CYS C SG  1 
ATOM   6180 N  N   . THR C 1 232 ? 33.749  11.127  -15.494 1.00 19.59 ? 232 THR C N   1 
ATOM   6181 C  CA  . THR C 1 232 ? 33.844  12.474  -14.899 1.00 20.33 ? 232 THR C CA  1 
ATOM   6182 C  C   . THR C 1 232 ? 35.135  12.639  -14.103 1.00 19.43 ? 232 THR C C   1 
ATOM   6183 O  O   . THR C 1 232 ? 35.801  11.669  -13.797 1.00 16.22 ? 232 THR C O   1 
ATOM   6184 C  CB  . THR C 1 232 ? 32.642  12.710  -13.998 1.00 20.31 ? 232 THR C CB  1 
ATOM   6185 O  OG1 . THR C 1 232 ? 32.399  11.509  -13.211 1.00 18.99 ? 232 THR C OG1 1 
ATOM   6186 C  CG2 . THR C 1 232 ? 31.440  13.091  -14.815 1.00 21.47 ? 232 THR C CG2 1 
ATOM   6187 N  N   . HIS C 1 233 ? 35.491  13.896  -13.760 1.00 23.54 ? 233 HIS C N   1 
ATOM   6188 C  CA  . HIS C 1 233 ? 36.700  14.129  -12.928 1.00 28.18 ? 233 HIS C CA  1 
ATOM   6189 C  C   . HIS C 1 233 ? 36.509  13.692  -11.515 1.00 31.97 ? 233 HIS C C   1 
ATOM   6190 O  O   . HIS C 1 233 ? 35.370  13.622  -11.029 1.00 28.07 ? 233 HIS C O   1 
ATOM   6191 C  CB  . HIS C 1 233 ? 37.078  15.593  -12.958 1.00 31.58 ? 233 HIS C CB  1 
ATOM   6192 C  CG  . HIS C 1 233 ? 37.702  16.028  -14.264 1.00 34.16 ? 233 HIS C CG  1 
ATOM   6193 N  ND1 . HIS C 1 233 ? 36.974  16.594  -15.271 1.00 38.44 ? 233 HIS C ND1 1 
ATOM   6194 C  CD2 . HIS C 1 233 ? 39.016  15.945  -14.721 1.00 35.73 ? 233 HIS C CD2 1 
ATOM   6195 C  CE1 . HIS C 1 233 ? 37.806  16.868  -16.317 1.00 39.40 ? 233 HIS C CE1 1 
ATOM   6196 N  NE2 . HIS C 1 233 ? 39.052  16.469  -15.970 1.00 38.38 ? 233 HIS C NE2 1 
ATOM   6197 N  N   . MET C 1 234 ? 37.636  13.392  -10.862 1.00 34.99 ? 234 MET C N   1 
ATOM   6198 C  CA  . MET C 1 234 ? 37.713  12.821  -9.508  1.00 42.09 ? 234 MET C CA  1 
ATOM   6199 C  C   . MET C 1 234 ? 36.796  13.369  -8.411  1.00 43.18 ? 234 MET C C   1 
ATOM   6200 O  O   . MET C 1 234 ? 36.329  12.624  -7.549  1.00 41.13 ? 234 MET C O   1 
ATOM   6201 C  CB  . MET C 1 234 ? 39.170  12.819  -9.001  1.00 42.43 ? 234 MET C CB  1 
ATOM   6202 C  CG  . MET C 1 234 ? 39.311  12.045  -7.692  1.00 46.96 ? 234 MET C CG  1 
ATOM   6203 S  SD  . MET C 1 234 ? 40.982  11.924  -7.047  1.00 50.80 ? 234 MET C SD  1 
ATOM   6204 C  CE  . MET C 1 234 ? 41.159  10.133  -6.856  1.00 36.26 ? 234 MET C CE  1 
ATOM   6205 N  N   . ASP C 1 235 ? 36.565  14.669  -8.458  1.00 44.12 ? 235 ASP C N   1 
ATOM   6206 C  CA  . ASP C 1 235 ? 35.877  15.367  -7.397  1.00 50.90 ? 235 ASP C CA  1 
ATOM   6207 C  C   . ASP C 1 235 ? 34.573  15.982  -7.904  1.00 51.85 ? 235 ASP C C   1 
ATOM   6208 O  O   . ASP C 1 235 ? 33.949  16.794  -7.207  1.00 47.89 ? 235 ASP C O   1 
ATOM   6209 C  CB  . ASP C 1 235 ? 36.820  16.441  -6.837  1.00 63.18 ? 235 ASP C CB  1 
ATOM   6210 C  CG  . ASP C 1 235 ? 37.726  17.044  -7.921  1.00 76.58 ? 235 ASP C CG  1 
ATOM   6211 O  OD1 . ASP C 1 235 ? 37.855  18.289  -7.955  1.00 79.77 ? 235 ASP C OD1 1 
ATOM   6212 O  OD2 . ASP C 1 235 ? 38.287  16.275  -8.752  1.00 77.34 ? 235 ASP C OD2 1 
ATOM   6213 N  N   . ASP C 1 236 ? 34.162  15.598  -9.118  1.00 45.44 ? 236 ASP C N   1 
ATOM   6214 C  CA  . ASP C 1 236 ? 32.800  15.868  -9.593  1.00 43.30 ? 236 ASP C CA  1 
ATOM   6215 C  C   . ASP C 1 236 ? 31.822  15.235  -8.598  1.00 41.71 ? 236 ASP C C   1 
ATOM   6216 O  O   . ASP C 1 236 ? 31.908  14.010  -8.342  1.00 38.58 ? 236 ASP C O   1 
ATOM   6217 C  CB  . ASP C 1 236 ? 32.573  15.315  -11.016 1.00 38.03 ? 236 ASP C CB  1 
ATOM   6218 C  CG  . ASP C 1 236 ? 31.324  15.897  -11.698 1.00 41.91 ? 236 ASP C CG  1 
ATOM   6219 O  OD1 . ASP C 1 236 ? 30.278  16.090  -11.013 1.00 49.05 ? 236 ASP C OD1 1 
ATOM   6220 O  OD2 . ASP C 1 236 ? 31.356  16.135  -12.941 1.00 43.46 ? 236 ASP C OD2 1 
ATOM   6221 N  N   . PRO C 1 237 ? 30.911  16.067  -8.021  1.00 45.44 ? 237 PRO C N   1 
ATOM   6222 C  CA  . PRO C 1 237 ? 29.878  15.623  -7.053  1.00 43.40 ? 237 PRO C CA  1 
ATOM   6223 C  C   . PRO C 1 237 ? 28.654  14.913  -7.725  1.00 47.05 ? 237 PRO C C   1 
ATOM   6224 O  O   . PRO C 1 237 ? 27.685  14.534  -7.034  1.00 42.05 ? 237 PRO C O   1 
ATOM   6225 C  CB  . PRO C 1 237 ? 29.440  16.940  -6.393  1.00 40.90 ? 237 PRO C CB  1 
ATOM   6226 C  CG  . PRO C 1 237 ? 29.670  18.004  -7.426  1.00 44.67 ? 237 PRO C CG  1 
ATOM   6227 C  CD  . PRO C 1 237 ? 30.772  17.513  -8.346  1.00 43.92 ? 237 PRO C CD  1 
ATOM   6228 N  N   . SER C 1 238 ? 28.690  14.797  -9.063  1.00 40.78 ? 238 SER C N   1 
ATOM   6229 C  CA  . SER C 1 238 ? 27.743  13.980  -9.834  1.00 36.09 ? 238 SER C CA  1 
ATOM   6230 C  C   . SER C 1 238 ? 28.526  13.045  -10.758 1.00 32.72 ? 238 SER C C   1 
ATOM   6231 O  O   . SER C 1 238 ? 28.593  13.308  -11.982 1.00 30.63 ? 238 SER C O   1 
ATOM   6232 C  CB  . SER C 1 238 ? 26.841  14.872  -10.707 1.00 39.64 ? 238 SER C CB  1 
ATOM   6233 O  OG  . SER C 1 238 ? 26.128  15.822  -9.926  1.00 43.02 ? 238 SER C OG  1 
ATOM   6234 N  N   . PRO C 1 239 ? 29.157  11.998  -10.195 1.00 32.52 ? 239 PRO C N   1 
ATOM   6235 C  CA  . PRO C 1 239 ? 29.943  11.064  -11.022 1.00 30.59 ? 239 PRO C CA  1 
ATOM   6236 C  C   . PRO C 1 239 ? 29.082  10.285  -11.992 1.00 30.54 ? 239 PRO C C   1 
ATOM   6237 O  O   . PRO C 1 239 ? 27.936  9.904   -11.685 1.00 30.74 ? 239 PRO C O   1 
ATOM   6238 C  CB  . PRO C 1 239 ? 30.517  10.063  -10.023 1.00 30.88 ? 239 PRO C CB  1 
ATOM   6239 C  CG  . PRO C 1 239 ? 29.726  10.298  -8.747  1.00 33.66 ? 239 PRO C CG  1 
ATOM   6240 C  CD  . PRO C 1 239 ? 29.337  11.729  -8.754  1.00 33.21 ? 239 PRO C CD  1 
ATOM   6241 N  N   . ARG C 1 240 ? 29.662  10.021  -13.136 1.00 24.60 ? 240 ARG C N   1 
ATOM   6242 C  CA  . ARG C 1 240 ? 28.994  9.225   -14.173 1.00 24.31 ? 240 ARG C CA  1 
ATOM   6243 C  C   . ARG C 1 240 ? 29.926  8.028   -14.483 1.00 23.82 ? 240 ARG C C   1 
ATOM   6244 O  O   . ARG C 1 240 ? 31.117  8.173   -14.754 1.00 20.91 ? 240 ARG C O   1 
ATOM   6245 C  CB  . ARG C 1 240 ? 28.714  10.044  -15.412 1.00 27.27 ? 240 ARG C CB  1 
ATOM   6246 C  CG  . ARG C 1 240 ? 27.707  11.189  -15.310 1.00 36.98 ? 240 ARG C CG  1 
ATOM   6247 C  CD  . ARG C 1 240 ? 27.563  11.944  -16.661 1.00 43.64 ? 240 ARG C CD  1 
ATOM   6248 N  NE  . ARG C 1 240 ? 28.505  13.062  -16.800 1.00 45.04 ? 240 ARG C NE  1 
ATOM   6249 C  CZ  . ARG C 1 240 ? 29.403  13.188  -17.778 1.00 50.88 ? 240 ARG C CZ  1 
ATOM   6250 N  NH1 . ARG C 1 240 ? 29.509  12.255  -18.716 1.00 45.60 ? 240 ARG C NH1 1 
ATOM   6251 N  NH2 . ARG C 1 240 ? 30.204  14.247  -17.816 1.00 57.53 ? 240 ARG C NH2 1 
ATOM   6252 N  N   . GLU C 1 241 ? 29.367  6.831   -14.449 1.00 23.22 ? 241 GLU C N   1 
ATOM   6253 C  CA  . GLU C 1 241 ? 30.104  5.617   -14.847 1.00 22.59 ? 241 GLU C CA  1 
ATOM   6254 C  C   . GLU C 1 241 ? 30.470  5.633   -16.335 1.00 21.42 ? 241 GLU C C   1 
ATOM   6255 O  O   . GLU C 1 241 ? 29.671  6.036   -17.159 1.00 21.10 ? 241 GLU C O   1 
ATOM   6256 C  CB  . GLU C 1 241 ? 29.295  4.362   -14.637 1.00 29.35 ? 241 GLU C CB  1 
ATOM   6257 C  CG  . GLU C 1 241 ? 29.022  4.028   -13.197 1.00 35.10 ? 241 GLU C CG  1 
ATOM   6258 C  CD  . GLU C 1 241 ? 27.742  3.246   -13.009 1.00 39.11 ? 241 GLU C CD  1 
ATOM   6259 O  OE1 . GLU C 1 241 ? 26.970  3.065   -13.983 1.00 46.01 ? 241 GLU C OE1 1 
ATOM   6260 O  OE2 . GLU C 1 241 ? 27.487  2.815   -11.857 1.00 48.47 ? 241 GLU C OE2 1 
ATOM   6261 N  N   . MET C 1 242 ? 31.650  5.125   -16.667 1.00 16.77 ? 242 MET C N   1 
ATOM   6262 C  CA  . MET C 1 242 ? 32.008  5.010   -18.101 1.00 14.55 ? 242 MET C CA  1 
ATOM   6263 C  C   . MET C 1 242 ? 31.543  3.632   -18.598 1.00 13.83 ? 242 MET C C   1 
ATOM   6264 O  O   . MET C 1 242 ? 32.138  2.577   -18.332 1.00 13.00 ? 242 MET C O   1 
ATOM   6265 C  CB  . MET C 1 242 ? 33.518  5.208   -18.283 1.00 14.13 ? 242 MET C CB  1 
ATOM   6266 C  CG  . MET C 1 242 ? 33.899  5.004   -19.770 1.00 14.23 ? 242 MET C CG  1 
ATOM   6267 S  SD  . MET C 1 242 ? 35.672  5.088   -20.000 1.00 15.46 ? 242 MET C SD  1 
ATOM   6268 C  CE  . MET C 1 242 ? 36.143  6.717   -19.467 1.00 16.59 ? 242 MET C CE  1 
ATOM   6269 N  N   . ILE C 1 243 ? 30.386  3.682   -19.267 1.00 12.97 ? 243 ILE C N   1 
ATOM   6270 C  CA  . ILE C 1 243 ? 29.728  2.500   -19.737 1.00 12.22 ? 243 ILE C CA  1 
ATOM   6271 C  C   . ILE C 1 243 ? 29.164  2.888   -21.133 1.00 10.60 ? 243 ILE C C   1 
ATOM   6272 O  O   . ILE C 1 243 ? 28.991  4.044   -21.473 1.00 10.66 ? 243 ILE C O   1 
ATOM   6273 C  CB  . ILE C 1 243 ? 28.561  2.031   -18.793 1.00 13.64 ? 243 ILE C CB  1 
ATOM   6274 C  CG1 . ILE C 1 243 ? 27.667  3.184   -18.425 1.00 14.95 ? 243 ILE C CG1 1 
ATOM   6275 C  CG2 . ILE C 1 243 ? 29.113  1.283   -17.542 1.00 13.34 ? 243 ILE C CG2 1 
ATOM   6276 C  CD1 . ILE C 1 243 ? 26.435  2.722   -17.606 1.00 16.34 ? 243 ILE C CD1 1 
ATOM   6277 N  N   . ASN C 1 244 ? 28.818  1.843   -21.856 1.00 9.06  ? 244 ASN C N   1 
ATOM   6278 C  CA  . ASN C 1 244 ? 28.108  1.990   -23.176 1.00 10.12 ? 244 ASN C CA  1 
ATOM   6279 C  C   . ASN C 1 244 ? 28.855  2.951   -24.135 1.00 9.54  ? 244 ASN C C   1 
ATOM   6280 O  O   . ASN C 1 244 ? 28.273  3.803   -24.775 1.00 9.63  ? 244 ASN C O   1 
ATOM   6281 C  CB  . ASN C 1 244 ? 26.675  2.404   -22.959 1.00 10.65 ? 244 ASN C CB  1 
ATOM   6282 C  CG  . ASN C 1 244 ? 25.937  1.466   -22.056 1.00 12.06 ? 244 ASN C CG  1 
ATOM   6283 O  OD1 . ASN C 1 244 ? 26.039  0.265   -22.149 1.00 16.35 ? 244 ASN C OD1 1 
ATOM   6284 N  ND2 . ASN C 1 244 ? 25.214  2.131   -21.090 1.00 14.75 ? 244 ASN C ND2 1 
ATOM   6285 N  N   . ASN C 1 245 ? 30.206  2.808   -24.117 1.00 9.00  ? 245 ASN C N   1 
ATOM   6286 C  CA  . ASN C 1 245 ? 31.021  3.774   -24.837 1.00 9.23  ? 245 ASN C CA  1 
ATOM   6287 C  C   . ASN C 1 245 ? 31.371  3.278   -26.249 1.00 8.39  ? 245 ASN C C   1 
ATOM   6288 O  O   . ASN C 1 245 ? 32.511  2.987   -26.603 1.00 9.60  ? 245 ASN C O   1 
ATOM   6289 C  CB  . ASN C 1 245 ? 32.293  4.105   -24.021 1.00 10.03 ? 245 ASN C CB  1 
ATOM   6290 C  CG  . ASN C 1 245 ? 33.126  2.904   -23.723 1.00 11.17 ? 245 ASN C CG  1 
ATOM   6291 O  OD1 . ASN C 1 245 ? 32.714  1.731   -23.719 1.00 10.66 ? 245 ASN C OD1 1 
ATOM   6292 N  ND2 . ASN C 1 245 ? 34.367  3.178   -23.366 1.00 14.02 ? 245 ASN C ND2 1 
ATOM   6293 N  N   . PHE C 1 246 ? 30.314  3.031   -26.973 1.00 8.05  ? 246 PHE C N   1 
ATOM   6294 C  CA  . PHE C 1 246 ? 30.389  2.457   -28.306 1.00 7.96  ? 246 PHE C CA  1 
ATOM   6295 C  C   . PHE C 1 246 ? 29.427  3.266   -29.142 1.00 7.09  ? 246 PHE C C   1 
ATOM   6296 O  O   . PHE C 1 246 ? 28.389  3.740   -28.649 1.00 7.67  ? 246 PHE C O   1 
ATOM   6297 C  CB  . PHE C 1 246 ? 30.064  0.920   -28.380 1.00 8.91  ? 246 PHE C CB  1 
ATOM   6298 C  CG  . PHE C 1 246 ? 28.696  0.564   -27.950 1.00 9.37  ? 246 PHE C CG  1 
ATOM   6299 C  CD1 . PHE C 1 246 ? 27.617  0.454   -28.876 1.00 10.30 ? 246 PHE C CD1 1 
ATOM   6300 C  CD2 . PHE C 1 246 ? 28.419  0.332   -26.595 1.00 10.16 ? 246 PHE C CD2 1 
ATOM   6301 C  CE1 . PHE C 1 246 ? 26.346  0.181   -28.454 1.00 10.16 ? 246 PHE C CE1 1 
ATOM   6302 C  CE2 . PHE C 1 246 ? 27.110  0.001   -26.151 1.00 11.00 ? 246 PHE C CE2 1 
ATOM   6303 C  CZ  . PHE C 1 246 ? 26.042  0.000   -27.083 1.00 10.26 ? 246 PHE C CZ  1 
ATOM   6304 N  N   . ARG C 1 247 ? 29.711  3.406   -30.446 1.00 5.66  ? 247 ARG C N   1 
ATOM   6305 C  CA  . ARG C 1 247 ? 28.776  4.075   -31.395 1.00 5.74  ? 247 ARG C CA  1 
ATOM   6306 C  C   . ARG C 1 247 ? 27.838  3.046   -31.965 1.00 5.38  ? 247 ARG C C   1 
ATOM   6307 O  O   . ARG C 1 247 ? 28.232  1.886   -32.193 1.00 5.80  ? 247 ARG C O   1 
ATOM   6308 C  CB  . ARG C 1 247 ? 29.607  4.688   -32.549 1.00 5.62  ? 247 ARG C CB  1 
ATOM   6309 C  CG  . ARG C 1 247 ? 28.866  5.741   -33.343 1.00 5.41  ? 247 ARG C CG  1 
ATOM   6310 C  CD  . ARG C 1 247 ? 29.675  6.140   -34.593 1.00 5.20  ? 247 ARG C CD  1 
ATOM   6311 N  NE  . ARG C 1 247 ? 29.070  7.291   -35.199 1.00 5.92  ? 247 ARG C NE  1 
ATOM   6312 C  CZ  . ARG C 1 247 ? 29.590  7.840   -36.303 1.00 5.77  ? 247 ARG C CZ  1 
ATOM   6313 N  NH1 . ARG C 1 247 ? 30.619  7.274   -36.937 1.00 6.29  ? 247 ARG C NH1 1 
ATOM   6314 N  NH2 . ARG C 1 247 ? 29.026  8.935   -36.806 1.00 6.12  ? 247 ARG C NH2 1 
ATOM   6315 N  N   . GLN C 1 248 ? 26.582  3.457   -32.195 1.00 5.72  ? 248 GLN C N   1 
ATOM   6316 C  CA  . GLN C 1 248 ? 25.626  2.538   -32.866 1.00 6.00  ? 248 GLN C CA  1 
ATOM   6317 C  C   . GLN C 1 248 ? 26.093  2.258   -34.318 1.00 6.65  ? 248 GLN C C   1 
ATOM   6318 O  O   . GLN C 1 248 ? 26.822  3.054   -34.938 1.00 6.07  ? 248 GLN C O   1 
ATOM   6319 C  CB  . GLN C 1 248 ? 24.278  3.243   -33.029 1.00 6.04  ? 248 GLN C CB  1 
ATOM   6320 C  CG  . GLN C 1 248 ? 23.609  3.568   -31.685 1.00 6.54  ? 248 GLN C CG  1 
ATOM   6321 C  CD  . GLN C 1 248 ? 23.248  2.340   -30.871 1.00 8.28  ? 248 GLN C CD  1 
ATOM   6322 O  OE1 . GLN C 1 248 ? 24.006  1.892   -29.964 1.00 9.76  ? 248 GLN C OE1 1 
ATOM   6323 N  NE2 . GLN C 1 248 ? 22.109  1.701   -31.268 1.00 8.79  ? 248 GLN C NE2 1 
ATOM   6324 N  N   . VAL C 1 249 ? 25.713  1.118   -34.864 1.00 6.21  ? 249 VAL C N   1 
ATOM   6325 C  CA  . VAL C 1 249 ? 26.056  0.775   -36.234 1.00 6.60  ? 249 VAL C CA  1 
ATOM   6326 C  C   . VAL C 1 249 ? 25.478  1.801   -37.230 1.00 6.16  ? 249 VAL C C   1 
ATOM   6327 O  O   . VAL C 1 249 ? 24.367  2.313   -37.039 1.00 6.49  ? 249 VAL C O   1 
ATOM   6328 C  CB  . VAL C 1 249 ? 25.659  -0.659  -36.644 1.00 8.19  ? 249 VAL C CB  1 
ATOM   6329 C  CG1 . VAL C 1 249 ? 26.538  -1.675  -35.882 1.00 9.23  ? 249 VAL C CG1 1 
ATOM   6330 C  CG2 . VAL C 1 249 ? 24.189  -0.835  -36.436 1.00 11.25 ? 249 VAL C CG2 1 
ATOM   6331 N  N   . GLN C 1 250 ? 26.202  2.006   -38.273 1.00 5.99  ? 250 GLN C N   1 
ATOM   6332 C  CA  . GLN C 1 250 ? 25.840  2.977   -39.344 1.00 6.27  ? 250 GLN C CA  1 
ATOM   6333 C  C   . GLN C 1 250 ? 25.243  2.238   -40.518 1.00 7.31  ? 250 GLN C C   1 
ATOM   6334 O  O   . GLN C 1 250 ? 25.592  1.064   -40.783 1.00 8.43  ? 250 GLN C O   1 
ATOM   6335 C  CB  . GLN C 1 250 ? 27.110  3.670   -39.781 1.00 6.22  ? 250 GLN C CB  1 
ATOM   6336 C  CG  . GLN C 1 250 ? 27.901  4.225   -38.558 1.00 5.61  ? 250 GLN C CG  1 
ATOM   6337 C  CD  . GLN C 1 250 ? 27.175  5.415   -37.922 1.00 5.32  ? 250 GLN C CD  1 
ATOM   6338 O  OE1 . GLN C 1 250 ? 26.943  6.448   -38.636 1.00 6.05  ? 250 GLN C OE1 1 
ATOM   6339 N  NE2 . GLN C 1 250 ? 26.811  5.363   -36.691 1.00 5.57  ? 250 GLN C NE2 1 
ATOM   6340 N  N   . LYS C 1 251 ? 24.393  2.956   -41.230 1.00 7.18  ? 251 LYS C N   1 
ATOM   6341 C  CA  . LYS C 1 251 ? 23.965  2.389   -42.538 1.00 8.05  ? 251 LYS C CA  1 
ATOM   6342 C  C   . LYS C 1 251 ? 25.167  2.098   -43.443 1.00 8.03  ? 251 LYS C C   1 
ATOM   6343 O  O   . LYS C 1 251 ? 26.097  2.880   -43.477 1.00 9.50  ? 251 LYS C O   1 
ATOM   6344 C  CB  . LYS C 1 251 ? 22.952  3.298   -43.219 1.00 8.63  ? 251 LYS C CB  1 
ATOM   6345 C  CG  . LYS C 1 251 ? 21.596  3.309   -42.475 1.00 10.87 ? 251 LYS C CG  1 
ATOM   6346 C  CD  . LYS C 1 251 ? 20.625  4.207   -43.143 1.00 11.65 ? 251 LYS C CD  1 
ATOM   6347 C  CE  . LYS C 1 251 ? 19.174  3.905   -42.725 1.00 9.87  ? 251 LYS C CE  1 
ATOM   6348 N  NZ  . LYS C 1 251 ? 18.945  4.053   -41.232 1.00 7.90  ? 251 LYS C NZ  1 
ATOM   6349 N  N   . PHE C 1 252 ? 25.059  0.995   -44.174 1.00 9.82  ? 252 PHE C N   1 
ATOM   6350 C  CA  . PHE C 1 252 ? 26.155  0.577   -45.098 1.00 10.14 ? 252 PHE C CA  1 
ATOM   6351 C  C   . PHE C 1 252 ? 25.465  -0.068  -46.258 1.00 14.67 ? 252 PHE C C   1 
ATOM   6352 O  O   . PHE C 1 252 ? 25.080  -1.227  -46.162 1.00 18.47 ? 252 PHE C O   1 
ATOM   6353 C  CB  . PHE C 1 252 ? 26.923  -0.475  -44.392 1.00 10.31 ? 252 PHE C CB  1 
ATOM   6354 C  CG  . PHE C 1 252 ? 28.168  -0.948  -45.068 1.00 10.04 ? 252 PHE C CG  1 
ATOM   6355 C  CD1 . PHE C 1 252 ? 29.363  -0.211  -44.979 1.00 10.72 ? 252 PHE C CD1 1 
ATOM   6356 C  CD2 . PHE C 1 252 ? 28.187  -2.198  -45.701 1.00 11.89 ? 252 PHE C CD2 1 
ATOM   6357 C  CE1 . PHE C 1 252 ? 30.560  -0.651  -45.586 1.00 10.45 ? 252 PHE C CE1 1 
ATOM   6358 C  CE2 . PHE C 1 252 ? 29.416  -2.658  -46.247 1.00 11.77 ? 252 PHE C CE2 1 
ATOM   6359 C  CZ  . PHE C 1 252 ? 30.553  -1.891  -46.167 1.00 10.82 ? 252 PHE C CZ  1 
ATOM   6360 N  N   . ASP C 1 253 ? 25.231  0.739   -47.249 1.00 16.79 ? 253 ASP C N   1 
ATOM   6361 C  CA  . ASP C 1 253 ? 24.378  0.368   -48.384 1.00 19.92 ? 253 ASP C CA  1 
ATOM   6362 C  C   . ASP C 1 253 ? 25.123  0.328   -49.720 1.00 16.65 ? 253 ASP C C   1 
ATOM   6363 O  O   . ASP C 1 253 ? 25.956  1.189   -50.005 1.00 17.70 ? 253 ASP C O   1 
ATOM   6364 C  CB  . ASP C 1 253 ? 23.225  1.389   -48.434 1.00 22.17 ? 253 ASP C CB  1 
ATOM   6365 C  CG  . ASP C 1 253 ? 22.053  0.947   -49.360 1.00 28.45 ? 253 ASP C CG  1 
ATOM   6366 O  OD1 . ASP C 1 253 ? 21.564  -0.229  -49.281 1.00 39.04 ? 253 ASP C OD1 1 
ATOM   6367 O  OD2 . ASP C 1 253 ? 21.664  1.801   -50.182 1.00 37.06 ? 253 ASP C OD2 1 
ATOM   6368 N  N   . GLU C 1 254 ? 24.836  -0.704  -50.503 1.00 16.99 ? 254 GLU C N   1 
ATOM   6369 C  CA  . GLU C 1 254 ? 25.490  -0.839  -51.818 1.00 19.75 ? 254 GLU C CA  1 
ATOM   6370 C  C   . GLU C 1 254 ? 26.991  -0.886  -51.675 1.00 16.91 ? 254 GLU C C   1 
ATOM   6371 O  O   . GLU C 1 254 ? 27.731  -0.324  -52.513 1.00 18.71 ? 254 GLU C O   1 
ATOM   6372 C  CB  . GLU C 1 254 ? 25.105  0.301   -52.791 1.00 23.62 ? 254 GLU C CB  1 
ATOM   6373 C  CG  . GLU C 1 254 ? 23.610  0.346   -53.142 1.00 32.82 ? 254 GLU C CG  1 
ATOM   6374 C  CD  . GLU C 1 254 ? 23.123  -0.935  -53.841 1.00 41.16 ? 254 GLU C CD  1 
ATOM   6375 O  OE1 . GLU C 1 254 ? 23.892  -1.533  -54.636 1.00 59.22 ? 254 GLU C OE1 1 
ATOM   6376 O  OE2 . GLU C 1 254 ? 21.967  -1.359  -53.634 1.00 43.80 ? 254 GLU C OE2 1 
ATOM   6377 N  N   . ARG C 1 255 ? 27.440  -1.511  -50.572 1.00 14.31 ? 255 ARG C N   1 
ATOM   6378 C  CA  . ARG C 1 255 ? 28.874  -1.679  -50.350 1.00 13.73 ? 255 ARG C CA  1 
ATOM   6379 C  C   . ARG C 1 255 ? 29.165  -3.127  -49.903 1.00 12.16 ? 255 ARG C C   1 
ATOM   6380 O  O   . ARG C 1 255 ? 28.324  -3.857  -49.373 1.00 14.01 ? 255 ARG C O   1 
ATOM   6381 C  CB  . ARG C 1 255 ? 29.460  -0.734  -49.303 1.00 12.75 ? 255 ARG C CB  1 
ATOM   6382 C  CG  . ARG C 1 255 ? 29.348  0.729   -49.708 1.00 13.26 ? 255 ARG C CG  1 
ATOM   6383 C  CD  . ARG C 1 255 ? 29.949  1.708   -48.663 1.00 12.45 ? 255 ARG C CD  1 
ATOM   6384 N  NE  . ARG C 1 255 ? 31.332  1.315   -48.487 1.00 13.28 ? 255 ARG C NE  1 
ATOM   6385 C  CZ  . ARG C 1 255 ? 32.056  1.630   -47.433 1.00 13.80 ? 255 ARG C CZ  1 
ATOM   6386 N  NH1 . ARG C 1 255 ? 31.540  2.359   -46.462 1.00 13.88 ? 255 ARG C NH1 1 
ATOM   6387 N  NH2 . ARG C 1 255 ? 33.310  1.207   -47.355 1.00 11.67 ? 255 ARG C NH2 1 
ATOM   6388 N  N   . LEU C 1 256 ? 30.419  -3.516  -50.066 1.00 11.78 ? 256 LEU C N   1 
ATOM   6389 C  CA  . LEU C 1 256 ? 30.844  -4.807  -49.597 1.00 12.25 ? 256 LEU C CA  1 
ATOM   6390 C  C   . LEU C 1 256 ? 31.904  -4.716  -48.462 1.00 10.79 ? 256 LEU C C   1 
ATOM   6391 O  O   . LEU C 1 256 ? 32.586  -3.706  -48.288 1.00 11.57 ? 256 LEU C O   1 
ATOM   6392 C  CB  . LEU C 1 256 ? 31.516  -5.563  -50.761 1.00 14.00 ? 256 LEU C CB  1 
ATOM   6393 C  CG  . LEU C 1 256 ? 30.623  -5.769  -51.984 1.00 18.11 ? 256 LEU C CG  1 
ATOM   6394 C  CD1 . LEU C 1 256 ? 31.436  -6.169  -53.176 1.00 19.92 ? 256 LEU C CD1 1 
ATOM   6395 C  CD2 . LEU C 1 256 ? 29.718  -6.949  -51.693 1.00 19.44 ? 256 LEU C CD2 1 
ATOM   6396 N  N   . VAL C 1 257 ? 31.945  -5.802  -47.696 1.00 11.58 ? 257 VAL C N   1 
ATOM   6397 C  CA  . VAL C 1 257 ? 33.015  -6.013  -46.765 1.00 10.23 ? 257 VAL C CA  1 
ATOM   6398 C  C   . VAL C 1 257 ? 33.778  -7.208  -47.329 1.00 9.52  ? 257 VAL C C   1 
ATOM   6399 O  O   . VAL C 1 257 ? 33.214  -8.278  -47.664 1.00 11.51 ? 257 VAL C O   1 
ATOM   6400 C  CB  . VAL C 1 257 ? 32.474  -6.403  -45.403 1.00 10.97 ? 257 VAL C CB  1 
ATOM   6401 C  CG1 . VAL C 1 257 ? 33.614  -6.804  -44.504 1.00 12.28 ? 257 VAL C CG1 1 
ATOM   6402 C  CG2 . VAL C 1 257 ? 31.688  -5.246  -44.789 1.00 13.05 ? 257 VAL C CG2 1 
ATOM   6403 N  N   . TYR C 1 258 ? 35.064  -7.038  -47.499 1.00 9.18  ? 258 TYR C N   1 
ATOM   6404 C  CA  . TYR C 1 258 ? 35.948  -8.045  -48.098 1.00 9.26  ? 258 TYR C CA  1 
ATOM   6405 C  C   . TYR C 1 258 ? 36.450  -8.972  -47.063 1.00 10.38 ? 258 TYR C C   1 
ATOM   6406 O  O   . TYR C 1 258 ? 36.746  -8.561  -45.944 1.00 10.52 ? 258 TYR C O   1 
ATOM   6407 C  CB  . TYR C 1 258 ? 37.021  -7.353  -48.872 1.00 10.55 ? 258 TYR C CB  1 
ATOM   6408 C  CG  . TYR C 1 258 ? 36.402  -6.467  -49.911 1.00 11.66 ? 258 TYR C CG  1 
ATOM   6409 C  CD1 . TYR C 1 258 ? 35.943  -6.993  -51.111 1.00 13.79 ? 258 TYR C CD1 1 
ATOM   6410 C  CD2 . TYR C 1 258 ? 36.212  -5.117  -49.669 1.00 14.42 ? 258 TYR C CD2 1 
ATOM   6411 C  CE1 . TYR C 1 258 ? 35.348  -6.189  -52.058 1.00 16.01 ? 258 TYR C CE1 1 
ATOM   6412 C  CE2 . TYR C 1 258 ? 35.619  -4.304  -50.608 1.00 15.08 ? 258 TYR C CE2 1 
ATOM   6413 C  CZ  . TYR C 1 258 ? 35.191  -4.846  -51.800 1.00 15.44 ? 258 TYR C CZ  1 
ATOM   6414 O  OH  . TYR C 1 258 ? 34.600  -4.036  -52.735 1.00 18.82 ? 258 TYR C OH  1 
ATOM   6415 N  N   . THR C 1 259 ? 36.530  -10.263 -47.373 1.00 9.22  ? 259 THR C N   1 
ATOM   6416 C  CA  . THR C 1 259 ? 36.980  -11.167 -46.342 1.00 9.27  ? 259 THR C CA  1 
ATOM   6417 C  C   . THR C 1 259 ? 38.198  -11.946 -46.843 1.00 9.89  ? 259 THR C C   1 
ATOM   6418 O  O   . THR C 1 259 ? 38.337  -12.206 -48.047 1.00 10.08 ? 259 THR C O   1 
ATOM   6419 C  CB  . THR C 1 259 ? 35.904  -12.188 -45.976 1.00 10.88 ? 259 THR C CB  1 
ATOM   6420 O  OG1 . THR C 1 259 ? 35.514  -12.911 -47.159 1.00 14.36 ? 259 THR C OG1 1 
ATOM   6421 C  CG2 . THR C 1 259 ? 34.627  -11.556 -45.436 1.00 9.80  ? 259 THR C CG2 1 
ATOM   6422 N  N   . SER C 1 260 ? 39.050  -12.325 -45.921 1.00 9.40  ? 260 SER C N   1 
ATOM   6423 C  CA  . SER C 1 260 ? 40.275  -13.039 -46.291 1.00 10.98 ? 260 SER C CA  1 
ATOM   6424 C  C   . SER C 1 260 ? 39.974  -14.524 -46.286 1.00 12.53 ? 260 SER C C   1 
ATOM   6425 O  O   . SER C 1 260 ? 40.922  -15.323 -46.639 1.00 15.55 ? 260 SER C O   1 
ATOM   6426 C  CB  . SER C 1 260 ? 41.356  -12.733 -45.298 1.00 10.79 ? 260 SER C CB  1 
ATOM   6427 O  OG  . SER C 1 260 ? 41.011  -13.303 -44.024 1.00 10.36 ? 260 SER C OG  1 
ATOM   6428 N  N   . PHE C 1 261 ? 38.739  -14.883 -45.958 1.00 11.33 ? 261 PHE C N   1 
ATOM   6429 C  CA  . PHE C 1 261 ? 38.333  -16.292 -45.818 1.00 13.84 ? 261 PHE C CA  1 
ATOM   6430 C  C   . PHE C 1 261 ? 37.189  -16.533 -46.764 1.00 16.38 ? 261 PHE C C   1 
ATOM   6431 O  O   . PHE C 1 261 ? 36.403  -15.642 -47.098 1.00 16.97 ? 261 PHE C O   1 
ATOM   6432 C  CB  . PHE C 1 261 ? 37.982  -16.639 -44.395 1.00 12.92 ? 261 PHE C CB  1 
ATOM   6433 C  CG  . PHE C 1 261 ? 36.951  -15.729 -43.758 1.00 12.51 ? 261 PHE C CG  1 
ATOM   6434 C  CD1 . PHE C 1 261 ? 35.598  -15.982 -43.831 1.00 12.44 ? 261 PHE C CD1 1 
ATOM   6435 C  CD2 . PHE C 1 261 ? 37.351  -14.558 -43.169 1.00 11.72 ? 261 PHE C CD2 1 
ATOM   6436 C  CE1 . PHE C 1 261 ? 34.662  -15.152 -43.246 1.00 15.71 ? 261 PHE C CE1 1 
ATOM   6437 C  CE2 . PHE C 1 261 ? 36.444  -13.725 -42.556 1.00 12.42 ? 261 PHE C CE2 1 
ATOM   6438 C  CZ  . PHE C 1 261 ? 35.085  -13.955 -42.613 1.00 14.09 ? 261 PHE C CZ  1 
ATOM   6439 N  N   . SER C 1 262 ? 37.142  -17.778 -47.268 1.00 24.73 ? 262 SER C N   1 
ATOM   6440 C  CA  . SER C 1 262 ? 36.025  -18.231 -48.140 1.00 35.03 ? 262 SER C CA  1 
ATOM   6441 C  C   . SER C 1 262 ? 34.889  -18.800 -47.308 1.00 43.79 ? 262 SER C C   1 
ATOM   6442 O  O   . SER C 1 262 ? 35.110  -19.691 -46.485 1.00 39.04 ? 262 SER C O   1 
ATOM   6443 C  CB  . SER C 1 262 ? 36.487  -19.305 -49.142 1.00 39.25 ? 262 SER C CB  1 
ATOM   6444 O  OG  . SER C 1 262 ? 37.914  -19.337 -49.380 1.00 40.23 ? 262 SER C OG  1 
ATOM   6445 N  N   . LYS D 1 3   ? 14.090  19.622  -45.630 1.00 28.41 ? 3   LYS D N   1 
ATOM   6446 C  CA  . LYS D 1 3   ? 14.866  18.790  -46.565 1.00 26.33 ? 3   LYS D CA  1 
ATOM   6447 C  C   . LYS D 1 3   ? 15.750  17.720  -45.836 1.00 22.76 ? 3   LYS D C   1 
ATOM   6448 O  O   . LYS D 1 3   ? 16.708  17.203  -46.420 1.00 21.18 ? 3   LYS D O   1 
ATOM   6449 C  CB  . LYS D 1 3   ? 15.714  19.644  -47.497 1.00 32.77 ? 3   LYS D CB  1 
ATOM   6450 C  CG  . LYS D 1 3   ? 16.690  20.561  -46.811 1.00 36.78 ? 3   LYS D CG  1 
ATOM   6451 C  CD  . LYS D 1 3   ? 17.757  20.937  -47.836 1.00 41.70 ? 3   LYS D CD  1 
ATOM   6452 C  CE  . LYS D 1 3   ? 19.111  20.953  -47.141 1.00 43.76 ? 3   LYS D CE  1 
ATOM   6453 N  NZ  . LYS D 1 3   ? 20.143  20.122  -47.808 1.00 42.88 ? 3   LYS D NZ  1 
ATOM   6454 N  N   . TRP D 1 4   ? 15.396  17.371  -44.566 1.00 13.42 ? 4   TRP D N   1 
ATOM   6455 C  CA  . TRP D 1 4   ? 16.026  16.157  -43.973 1.00 11.36 ? 4   TRP D CA  1 
ATOM   6456 C  C   . TRP D 1 4   ? 15.695  14.965  -44.826 1.00 10.38 ? 4   TRP D C   1 
ATOM   6457 O  O   . TRP D 1 4   ? 14.715  14.900  -45.572 1.00 10.76 ? 4   TRP D O   1 
ATOM   6458 C  CB  . TRP D 1 4   ? 15.517  15.960  -42.549 1.00 9.29  ? 4   TRP D CB  1 
ATOM   6459 C  CG  . TRP D 1 4   ? 14.056  15.658  -42.397 1.00 7.66  ? 4   TRP D CG  1 
ATOM   6460 C  CD1 . TRP D 1 4   ? 13.043  16.532  -42.088 1.00 8.39  ? 4   TRP D CD1 1 
ATOM   6461 C  CD2 . TRP D 1 4   ? 13.418  14.325  -42.392 1.00 7.60  ? 4   TRP D CD2 1 
ATOM   6462 N  NE1 . TRP D 1 4   ? 11.839  15.877  -41.959 1.00 8.75  ? 4   TRP D NE1 1 
ATOM   6463 C  CE2 . TRP D 1 4   ? 12.009  14.540  -42.130 1.00 7.18  ? 4   TRP D CE2 1 
ATOM   6464 C  CE3 . TRP D 1 4   ? 13.925  13.034  -42.541 1.00 8.07  ? 4   TRP D CE3 1 
ATOM   6465 C  CZ2 . TRP D 1 4   ? 11.106  13.469  -42.022 1.00 8.23  ? 4   TRP D CZ2 1 
ATOM   6466 C  CZ3 . TRP D 1 4   ? 12.956  11.969  -42.441 1.00 7.85  ? 4   TRP D CZ3 1 
ATOM   6467 C  CH2 . TRP D 1 4   ? 11.628  12.223  -42.206 1.00 7.76  ? 4   TRP D CH2 1 
ATOM   6468 N  N   . THR D 1 5   ? 16.617  14.006  -44.758 1.00 8.20  ? 5   THR D N   1 
ATOM   6469 C  CA  . THR D 1 5   ? 16.508  12.805  -45.585 1.00 8.76  ? 5   THR D CA  1 
ATOM   6470 C  C   . THR D 1 5   ? 16.944  11.599  -44.758 1.00 8.80  ? 5   THR D C   1 
ATOM   6471 O  O   . THR D 1 5   ? 17.314  11.698  -43.602 1.00 7.66  ? 5   THR D O   1 
ATOM   6472 C  CB  . THR D 1 5   ? 17.407  12.801  -46.845 1.00 10.07 ? 5   THR D CB  1 
ATOM   6473 O  OG1 . THR D 1 5   ? 18.740  12.726  -46.371 1.00 10.71 ? 5   THR D OG1 1 
ATOM   6474 C  CG2 . THR D 1 5   ? 17.192  14.014  -47.742 1.00 9.46  ? 5   THR D CG2 1 
ATOM   6475 N  N   . TYR D 1 6   ? 16.938  10.399  -45.353 1.00 8.26  ? 6   TYR D N   1 
ATOM   6476 C  CA  . TYR D 1 6   ? 17.540  9.250   -44.754 1.00 7.61  ? 6   TYR D CA  1 
ATOM   6477 C  C   . TYR D 1 6   ? 18.857  8.815   -45.326 1.00 9.28  ? 6   TYR D C   1 
ATOM   6478 O  O   . TYR D 1 6   ? 19.412  7.754   -44.993 1.00 9.81  ? 6   TYR D O   1 
ATOM   6479 C  CB  . TYR D 1 6   ? 16.552  8.043   -44.952 1.00 8.50  ? 6   TYR D CB  1 
ATOM   6480 C  CG  . TYR D 1 6   ? 15.315  8.125   -44.108 1.00 6.58  ? 6   TYR D CG  1 
ATOM   6481 C  CD1 . TYR D 1 6   ? 15.319  7.619   -42.815 1.00 7.52  ? 6   TYR D CD1 1 
ATOM   6482 C  CD2 . TYR D 1 6   ? 14.147  8.658   -44.607 1.00 7.08  ? 6   TYR D CD2 1 
ATOM   6483 C  CE1 . TYR D 1 6   ? 14.152  7.656   -42.043 1.00 7.49  ? 6   TYR D CE1 1 
ATOM   6484 C  CE2 . TYR D 1 6   ? 12.992  8.674   -43.808 1.00 7.08  ? 6   TYR D CE2 1 
ATOM   6485 C  CZ  . TYR D 1 6   ? 13.037  8.167   -42.530 1.00 6.41  ? 6   TYR D CZ  1 
ATOM   6486 O  OH  . TYR D 1 6   ? 11.850  8.111   -41.854 1.00 7.30  ? 6   TYR D OH  1 
ATOM   6487 N  N   . PHE D 1 7   ? 19.410  9.626   -46.209 1.00 10.62 ? 7   PHE D N   1 
ATOM   6488 C  CA  . PHE D 1 7   ? 20.630  9.256   -46.935 1.00 12.58 ? 7   PHE D CA  1 
ATOM   6489 C  C   . PHE D 1 7   ? 21.394  10.525  -47.305 1.00 12.65 ? 7   PHE D C   1 
ATOM   6490 O  O   . PHE D 1 7   ? 20.829  11.366  -47.995 1.00 14.46 ? 7   PHE D O   1 
ATOM   6491 C  CB  . PHE D 1 7   ? 20.289  8.482   -48.272 1.00 16.40 ? 7   PHE D CB  1 
ATOM   6492 C  CG  . PHE D 1 7   ? 21.522  8.042   -49.040 1.00 20.38 ? 7   PHE D CG  1 
ATOM   6493 C  CD1 . PHE D 1 7   ? 22.313  6.997   -48.588 1.00 22.81 ? 7   PHE D CD1 1 
ATOM   6494 C  CD2 . PHE D 1 7   ? 21.876  8.725   -50.226 1.00 24.83 ? 7   PHE D CD2 1 
ATOM   6495 C  CE1 . PHE D 1 7   ? 23.459  6.575   -49.314 1.00 25.89 ? 7   PHE D CE1 1 
ATOM   6496 C  CE2 . PHE D 1 7   ? 23.001  8.338   -50.941 1.00 29.26 ? 7   PHE D CE2 1 
ATOM   6497 C  CZ  . PHE D 1 7   ? 23.765  7.250   -50.500 1.00 30.32 ? 7   PHE D CZ  1 
ATOM   6498 N  N   . GLY D 1 8   ? 22.697  10.488  -47.069 1.00 12.96 ? 8   GLY D N   1 
ATOM   6499 C  CA  . GLY D 1 8   ? 23.525  11.592  -47.593 1.00 13.87 ? 8   GLY D CA  1 
ATOM   6500 C  C   . GLY D 1 8   ? 23.716  12.645  -46.543 1.00 15.06 ? 8   GLY D C   1 
ATOM   6501 O  O   . GLY D 1 8   ? 23.507  12.442  -45.329 1.00 14.15 ? 8   GLY D O   1 
ATOM   6502 N  N   . PRO D 1 9   ? 24.111  13.838  -46.984 1.00 14.44 ? 9   PRO D N   1 
ATOM   6503 C  CA  . PRO D 1 9   ? 24.525  14.824  -46.006 1.00 13.87 ? 9   PRO D CA  1 
ATOM   6504 C  C   . PRO D 1 9   ? 23.451  15.315  -45.061 1.00 12.43 ? 9   PRO D C   1 
ATOM   6505 O  O   . PRO D 1 9   ? 23.759  15.865  -43.980 1.00 13.41 ? 9   PRO D O   1 
ATOM   6506 C  CB  . PRO D 1 9   ? 25.028  16.057  -46.856 1.00 14.34 ? 9   PRO D CB  1 
ATOM   6507 C  CG  . PRO D 1 9   ? 25.013  15.594  -48.263 1.00 18.90 ? 9   PRO D CG  1 
ATOM   6508 C  CD  . PRO D 1 9   ? 24.297  14.238  -48.403 1.00 15.78 ? 9   PRO D CD  1 
ATOM   6509 N  N   . ASP D 1 10  ? 22.142  15.159  -45.416 1.00 10.37 ? 10  ASP D N   1 
ATOM   6510 C  CA  . ASP D 1 10  ? 21.039  15.575  -44.568 1.00 10.63 ? 10  ASP D CA  1 
ATOM   6511 C  C   . ASP D 1 10  ? 20.333  14.365  -43.913 1.00 8.32  ? 10  ASP D C   1 
ATOM   6512 O  O   . ASP D 1 10  ? 19.244  14.525  -43.421 1.00 9.00  ? 10  ASP D O   1 
ATOM   6513 C  CB  . ASP D 1 10  ? 20.022  16.367  -45.390 1.00 12.70 ? 10  ASP D CB  1 
ATOM   6514 C  CG  . ASP D 1 10  ? 20.660  17.668  -45.949 1.00 18.25 ? 10  ASP D CG  1 
ATOM   6515 O  OD1 . ASP D 1 10  ? 21.315  18.433  -45.208 1.00 20.85 ? 10  ASP D OD1 1 
ATOM   6516 O  OD2 . ASP D 1 10  ? 20.496  17.874  -47.143 1.00 22.89 ? 10  ASP D OD2 1 
ATOM   6517 N  N   . GLY D 1 11  ? 21.068  13.283  -43.885 1.00 8.31  ? 11  GLY D N   1 
ATOM   6518 C  CA  . GLY D 1 11  ? 20.528  12.055  -43.308 1.00 6.70  ? 11  GLY D CA  1 
ATOM   6519 C  C   . GLY D 1 11  ? 20.634  12.064  -41.790 1.00 6.76  ? 11  GLY D C   1 
ATOM   6520 O  O   . GLY D 1 11  ? 20.834  13.082  -41.116 1.00 5.76  ? 11  GLY D O   1 
ATOM   6521 N  N   . GLU D 1 12  ? 20.349  10.913  -41.169 1.00 5.45  ? 12  GLU D N   1 
ATOM   6522 C  CA  . GLU D 1 12  ? 19.975  10.889  -39.778 1.00 5.41  ? 12  GLU D CA  1 
ATOM   6523 C  C   . GLU D 1 12  ? 21.026  11.367  -38.762 1.00 5.25  ? 12  GLU D C   1 
ATOM   6524 O  O   . GLU D 1 12  ? 20.650  11.832  -37.719 1.00 5.45  ? 12  GLU D O   1 
ATOM   6525 C  CB  . GLU D 1 12  ? 19.474  9.443   -39.294 1.00 5.73  ? 12  GLU D CB  1 
ATOM   6526 C  CG  . GLU D 1 12  ? 20.578  8.399   -39.255 1.00 6.30  ? 12  GLU D CG  1 
ATOM   6527 C  CD  . GLU D 1 12  ? 19.957  7.009   -39.296 1.00 6.44  ? 12  GLU D CD  1 
ATOM   6528 O  OE1 . GLU D 1 12  ? 19.616  6.562   -38.186 1.00 6.65  ? 12  GLU D OE1 1 
ATOM   6529 O  OE2 . GLU D 1 12  ? 19.819  6.482   -40.384 1.00 8.57  ? 12  GLU D OE2 1 
ATOM   6530 N  N   . ASN D 1 13  ? 22.314  11.240  -39.129 1.00 5.20  ? 13  ASN D N   1 
ATOM   6531 C  CA  . ASN D 1 13  ? 23.290  11.731  -38.162 1.00 5.38  ? 13  ASN D CA  1 
ATOM   6532 C  C   . ASN D 1 13  ? 23.349  13.269  -38.198 1.00 5.87  ? 13  ASN D C   1 
ATOM   6533 O  O   . ASN D 1 13  ? 23.964  13.796  -37.261 1.00 6.85  ? 13  ASN D O   1 
ATOM   6534 C  CB  . ASN D 1 13  ? 24.687  11.181  -38.536 1.00 5.90  ? 13  ASN D CB  1 
ATOM   6535 C  CG  . ASN D 1 13  ? 24.823  9.716   -38.210 1.00 5.75  ? 13  ASN D CG  1 
ATOM   6536 O  OD1 . ASN D 1 13  ? 23.900  9.061   -37.714 1.00 7.40  ? 13  ASN D OD1 1 
ATOM   6537 N  ND2 . ASN D 1 13  ? 25.976  9.212   -38.567 1.00 6.34  ? 13  ASN D ND2 1 
ATOM   6538 N  N   . SER D 1 14  ? 22.656  13.882  -39.100 1.00 5.76  ? 14  SER D N   1 
ATOM   6539 C  CA  . SER D 1 14  ? 22.587  15.365  -39.215 1.00 5.74  ? 14  SER D CA  1 
ATOM   6540 C  C   . SER D 1 14  ? 21.301  15.907  -38.754 1.00 6.50  ? 14  SER D C   1 
ATOM   6541 O  O   . SER D 1 14  ? 21.227  17.155  -38.630 1.00 6.90  ? 14  SER D O   1 
ATOM   6542 C  CB  . SER D 1 14  ? 22.905  15.794  -40.637 1.00 6.81  ? 14  SER D CB  1 
ATOM   6543 O  OG  . SER D 1 14  ? 24.279  15.468  -40.901 1.00 9.09  ? 14  SER D OG  1 
ATOM   6544 N  N   . TRP D 1 15  ? 20.279  15.138  -38.421 1.00 5.64  ? 15  TRP D N   1 
ATOM   6545 C  CA  . TRP D 1 15  ? 18.988  15.724  -38.127 1.00 5.55  ? 15  TRP D CA  1 
ATOM   6546 C  C   . TRP D 1 15  ? 19.110  16.645  -36.914 1.00 5.62  ? 15  TRP D C   1 
ATOM   6547 O  O   . TRP D 1 15  ? 18.347  17.617  -36.849 1.00 6.34  ? 15  TRP D O   1 
ATOM   6548 C  CB  . TRP D 1 15  ? 18.027  14.585  -37.708 1.00 5.85  ? 15  TRP D CB  1 
ATOM   6549 C  CG  . TRP D 1 15  ? 17.658  13.717  -38.854 1.00 6.13  ? 15  TRP D CG  1 
ATOM   6550 C  CD1 . TRP D 1 15  ? 17.878  13.872  -40.207 1.00 5.05  ? 15  TRP D CD1 1 
ATOM   6551 C  CD2 . TRP D 1 15  ? 16.843  12.495  -38.742 1.00 5.62  ? 15  TRP D CD2 1 
ATOM   6552 N  NE1 . TRP D 1 15  ? 17.291  12.824  -40.931 1.00 5.93  ? 15  TRP D NE1 1 
ATOM   6553 C  CE2 . TRP D 1 15  ? 16.633  12.003  -40.081 1.00 5.31  ? 15  TRP D CE2 1 
ATOM   6554 C  CE3 . TRP D 1 15  ? 16.259  11.841  -37.682 1.00 5.62  ? 15  TRP D CE3 1 
ATOM   6555 C  CZ2 . TRP D 1 15  ? 15.907  10.788  -40.369 1.00 5.90  ? 15  TRP D CZ2 1 
ATOM   6556 C  CZ3 . TRP D 1 15  ? 15.549  10.653  -37.933 1.00 5.92  ? 15  TRP D CZ3 1 
ATOM   6557 C  CH2 . TRP D 1 15  ? 15.343  10.162  -39.236 1.00 5.30  ? 15  TRP D CH2 1 
ATOM   6558 N  N   A SER D 1 16  ? 19.933  16.339  -35.951 0.50 5.41  ? 16  SER D N   1 
ATOM   6559 N  N   B SER D 1 16  ? 19.967  16.344  -35.963 0.50 6.23  ? 16  SER D N   1 
ATOM   6560 C  CA  A SER D 1 16  ? 19.950  17.103  -34.677 0.50 5.54  ? 16  SER D CA  1 
ATOM   6561 C  CA  B SER D 1 16  ? 20.039  17.098  -34.670 0.50 6.96  ? 16  SER D CA  1 
ATOM   6562 C  C   A SER D 1 16  ? 20.417  18.534  -34.961 0.50 5.98  ? 16  SER D C   1 
ATOM   6563 C  C   B SER D 1 16  ? 20.621  18.492  -34.890 0.50 6.92  ? 16  SER D C   1 
ATOM   6564 O  O   A SER D 1 16  ? 20.147  19.379  -34.117 0.50 5.52  ? 16  SER D O   1 
ATOM   6565 O  O   B SER D 1 16  ? 20.578  19.299  -33.973 0.50 6.64  ? 16  SER D O   1 
ATOM   6566 C  CB  A SER D 1 16  ? 20.919  16.455  -33.735 0.50 5.20  ? 16  SER D CB  1 
ATOM   6567 C  CB  B SER D 1 16  ? 20.886  16.341  -33.681 0.50 7.84  ? 16  SER D CB  1 
ATOM   6568 O  OG  A SER D 1 16  ? 22.219  16.555  -34.265 0.50 4.87  ? 16  SER D OG  1 
ATOM   6569 O  OG  B SER D 1 16  ? 20.312  15.055  -33.466 0.50 11.60 ? 16  SER D OG  1 
ATOM   6570 N  N   . LYS D 1 17  ? 21.086  18.761  -36.101 1.00 6.77  ? 17  LYS D N   1 
ATOM   6571 C  CA  . LYS D 1 17  ? 21.585  20.143  -36.377 1.00 6.87  ? 17  LYS D CA  1 
ATOM   6572 C  C   . LYS D 1 17  ? 20.365  21.030  -36.475 1.00 8.88  ? 17  LYS D C   1 
ATOM   6573 O  O   . LYS D 1 17  ? 20.530  22.273  -36.119 1.00 9.03  ? 17  LYS D O   1 
ATOM   6574 C  CB  . LYS D 1 17  ? 22.331  20.201  -37.659 1.00 7.72  ? 17  LYS D CB  1 
ATOM   6575 C  CG  . LYS D 1 17  ? 23.609  19.340  -37.700 1.00 9.27  ? 17  LYS D CG  1 
ATOM   6576 C  CD  . LYS D 1 17  ? 24.114  19.265  -39.130 1.00 8.70  ? 17  LYS D CD  1 
ATOM   6577 C  CE  . LYS D 1 17  ? 25.314  18.365  -39.259 1.00 9.01  ? 17  LYS D CE  1 
ATOM   6578 N  NZ  . LYS D 1 17  ? 25.950  18.522  -40.600 1.00 11.19 ? 17  LYS D NZ  1 
ATOM   6579 N  N   . LYS D 1 18  ? 19.230  20.601  -36.966 1.00 8.06  ? 18  LYS D N   1 
ATOM   6580 C  CA  . LYS D 1 18  ? 18.034  21.453  -37.086 1.00 8.13  ? 18  LYS D CA  1 
ATOM   6581 C  C   . LYS D 1 18  ? 16.967  21.056  -36.105 1.00 9.04  ? 18  LYS D C   1 
ATOM   6582 O  O   . LYS D 1 18  ? 16.078  21.839  -35.866 1.00 10.74 ? 18  LYS D O   1 
ATOM   6583 C  CB  . LYS D 1 18  ? 17.409  21.317  -38.461 1.00 10.05 ? 18  LYS D CB  1 
ATOM   6584 C  CG  . LYS D 1 18  ? 18.221  22.057  -39.595 1.00 16.96 ? 18  LYS D CG  1 
ATOM   6585 C  CD  . LYS D 1 18  ? 17.776  21.625  -40.992 1.00 19.07 ? 18  LYS D CD  1 
ATOM   6586 C  CE  . LYS D 1 18  ? 18.480  22.463  -42.111 1.00 27.43 ? 18  LYS D CE  1 
ATOM   6587 N  NZ  . LYS D 1 18  ? 17.957  22.119  -43.483 1.00 32.65 ? 18  LYS D NZ  1 
ATOM   6588 N  N   . TYR D 1 19  ? 16.985  19.876  -35.544 1.00 7.62  ? 19  TYR D N   1 
ATOM   6589 C  CA  . TYR D 1 19  ? 15.900  19.368  -34.762 1.00 7.29  ? 19  TYR D CA  1 
ATOM   6590 C  C   . TYR D 1 19  ? 16.518  18.856  -33.478 1.00 7.08  ? 19  TYR D C   1 
ATOM   6591 O  O   . TYR D 1 19  ? 16.968  17.674  -33.423 1.00 7.07  ? 19  TYR D O   1 
ATOM   6592 C  CB  . TYR D 1 19  ? 15.237  18.132  -35.535 1.00 7.04  ? 19  TYR D CB  1 
ATOM   6593 C  CG  . TYR D 1 19  ? 14.617  18.552  -36.815 1.00 6.87  ? 19  TYR D CG  1 
ATOM   6594 C  CD1 . TYR D 1 19  ? 13.404  19.272  -36.877 1.00 8.43  ? 19  TYR D CD1 1 
ATOM   6595 C  CD2 . TYR D 1 19  ? 15.277  18.332  -38.015 1.00 6.80  ? 19  TYR D CD2 1 
ATOM   6596 C  CE1 . TYR D 1 19  ? 12.894  19.620  -38.080 1.00 9.77  ? 19  TYR D CE1 1 
ATOM   6597 C  CE2 . TYR D 1 19  ? 14.780  18.722  -39.190 1.00 8.28  ? 19  TYR D CE2 1 
ATOM   6598 C  CZ  . TYR D 1 19  ? 13.603  19.392  -39.220 1.00 9.68  ? 19  TYR D CZ  1 
ATOM   6599 O  OH  . TYR D 1 19  ? 13.034  19.759  -40.456 1.00 14.47 ? 19  TYR D OH  1 
ATOM   6600 N  N   . PRO D 1 20  ? 16.646  19.667  -32.428 1.00 6.86  ? 20  PRO D N   1 
ATOM   6601 C  CA  . PRO D 1 20  ? 17.420  19.293  -31.305 1.00 8.40  ? 20  PRO D CA  1 
ATOM   6602 C  C   . PRO D 1 20  ? 16.977  18.009  -30.588 1.00 7.13  ? 20  PRO D C   1 
ATOM   6603 O  O   . PRO D 1 20  ? 17.812  17.359  -30.015 1.00 7.49  ? 20  PRO D O   1 
ATOM   6604 C  CB  . PRO D 1 20  ? 17.302  20.490  -30.326 1.00 8.89  ? 20  PRO D CB  1 
ATOM   6605 C  CG  . PRO D 1 20  ? 16.564  21.456  -31.031 1.00 10.81 ? 20  PRO D CG  1 
ATOM   6606 C  CD  . PRO D 1 20  ? 16.105  21.059  -32.408 1.00 7.57  ? 20  PRO D CD  1 
ATOM   6607 N  N   . SER D 1 21  ? 15.674  17.729  -30.617 1.00 7.20  ? 21  SER D N   1 
ATOM   6608 C  CA  . SER D 1 21  ? 15.250  16.519  -29.908 1.00 6.43  ? 21  SER D CA  1 
ATOM   6609 C  C   . SER D 1 21  ? 15.814  15.287  -30.576 1.00 6.47  ? 21  SER D C   1 
ATOM   6610 O  O   . SER D 1 21  ? 15.814  14.268  -29.876 1.00 7.22  ? 21  SER D O   1 
ATOM   6611 C  CB  . SER D 1 21  ? 13.726  16.377  -29.861 1.00 6.60  ? 21  SER D CB  1 
ATOM   6612 O  OG  . SER D 1 21  ? 13.178  17.439  -29.036 1.00 10.82 ? 21  SER D OG  1 
ATOM   6613 N  N   . CYS D 1 22  ? 16.258  15.306  -31.843 1.00 6.49  ? 22  CYS D N   1 
ATOM   6614 C  CA  . CYS D 1 22  ? 16.835  14.116  -32.422 1.00 6.61  ? 22  CYS D CA  1 
ATOM   6615 C  C   . CYS D 1 22  ? 18.132  13.775  -31.793 1.00 7.26  ? 22  CYS D C   1 
ATOM   6616 O  O   . CYS D 1 22  ? 18.599  12.671  -31.975 1.00 8.20  ? 22  CYS D O   1 
ATOM   6617 C  CB  . CYS D 1 22  ? 17.029  14.304  -33.898 1.00 7.01  ? 22  CYS D CB  1 
ATOM   6618 S  SG  . CYS D 1 22  ? 15.458  14.640  -34.823 1.00 7.20  ? 22  CYS D SG  1 
ATOM   6619 N  N   . GLY D 1 23  ? 18.736  14.685  -31.001 1.00 8.55  ? 23  GLY D N   1 
ATOM   6620 C  CA  . GLY D 1 23  ? 19.955  14.442  -30.232 1.00 8.76  ? 23  GLY D CA  1 
ATOM   6621 C  C   . GLY D 1 23  ? 19.711  14.369  -28.749 1.00 10.74 ? 23  GLY D C   1 
ATOM   6622 O  O   . GLY D 1 23  ? 20.646  14.361  -27.903 1.00 11.85 ? 23  GLY D O   1 
ATOM   6623 N  N   . GLY D 1 24  ? 18.441  14.257  -28.399 1.00 10.45 ? 24  GLY D N   1 
ATOM   6624 C  CA  . GLY D 1 24  ? 17.964  14.274  -26.961 1.00 12.46 ? 24  GLY D CA  1 
ATOM   6625 C  C   . GLY D 1 24  ? 17.767  12.865  -26.442 1.00 13.74 ? 24  GLY D C   1 
ATOM   6626 O  O   . GLY D 1 24  ? 18.225  11.905  -27.031 1.00 14.10 ? 24  GLY D O   1 
ATOM   6627 N  N   . LEU D 1 25  ? 17.150  12.757  -25.305 1.00 16.18 ? 25  LEU D N   1 
ATOM   6628 C  CA  . LEU D 1 25  ? 16.998  11.437  -24.740 1.00 17.70 ? 25  LEU D CA  1 
ATOM   6629 C  C   . LEU D 1 25  ? 15.708  10.746  -25.342 1.00 12.96 ? 25  LEU D C   1 
ATOM   6630 O  O   . LEU D 1 25  ? 14.866  11.341  -26.079 1.00 12.17 ? 25  LEU D O   1 
ATOM   6631 C  CB  . LEU D 1 25  ? 16.894  11.522  -23.184 1.00 22.87 ? 25  LEU D CB  1 
ATOM   6632 C  CG  . LEU D 1 25  ? 18.077  12.173  -22.399 1.00 23.24 ? 25  LEU D CG  1 
ATOM   6633 C  CD1 . LEU D 1 25  ? 17.614  12.438  -20.980 1.00 28.44 ? 25  LEU D CD1 1 
ATOM   6634 C  CD2 . LEU D 1 25  ? 19.247  11.199  -22.409 1.00 29.52 ? 25  LEU D CD2 1 
ATOM   6635 N  N   . LEU D 1 26  ? 15.558  9.495   -24.942 1.00 13.11 ? 26  LEU D N   1 
ATOM   6636 C  CA  . LEU D 1 26  ? 14.392  8.680   -25.201 1.00 11.34 ? 26  LEU D CA  1 
ATOM   6637 C  C   . LEU D 1 26  ? 14.059  8.495   -26.636 1.00 8.27  ? 26  LEU D C   1 
ATOM   6638 O  O   . LEU D 1 26  ? 12.902  8.511   -27.052 1.00 9.47  ? 26  LEU D O   1 
ATOM   6639 C  CB  . LEU D 1 26  ? 13.194  9.303   -24.495 1.00 15.16 ? 26  LEU D CB  1 
ATOM   6640 C  CG  . LEU D 1 26  ? 13.115  9.317   -22.977 1.00 24.89 ? 26  LEU D CG  1 
ATOM   6641 C  CD1 . LEU D 1 26  ? 11.648  9.176   -22.652 1.00 29.65 ? 26  LEU D CD1 1 
ATOM   6642 C  CD2 . LEU D 1 26  ? 13.930  8.212   -22.330 1.00 22.95 ? 26  LEU D CD2 1 
ATOM   6643 N  N   . GLN D 1 27  ? 15.093  8.328   -27.425 1.00 7.43  ? 27  GLN D N   1 
ATOM   6644 C  CA  . GLN D 1 27  ? 14.824  8.219   -28.856 1.00 6.37  ? 27  GLN D CA  1 
ATOM   6645 C  C   . GLN D 1 27  ? 14.464  6.819   -29.296 1.00 5.88  ? 27  GLN D C   1 
ATOM   6646 O  O   . GLN D 1 27  ? 14.862  5.798   -28.687 1.00 7.18  ? 27  GLN D O   1 
ATOM   6647 C  CB  . GLN D 1 27  ? 16.119  8.677   -29.629 1.00 6.53  ? 27  GLN D CB  1 
ATOM   6648 C  CG  . GLN D 1 27  ? 16.441  10.163  -29.388 1.00 7.31  ? 27  GLN D CG  1 
ATOM   6649 C  CD  . GLN D 1 27  ? 15.394  10.982  -30.052 1.00 6.04  ? 27  GLN D CD  1 
ATOM   6650 O  OE1 . GLN D 1 27  ? 15.412  11.135  -31.303 1.00 6.15  ? 27  GLN D OE1 1 
ATOM   6651 N  NE2 . GLN D 1 27  ? 14.446  11.519  -29.303 1.00 6.30  ? 27  GLN D NE2 1 
ATOM   6652 N  N   . SER D 1 28  ? 13.726  6.773   -30.398 1.00 4.98  ? 28  SER D N   1 
ATOM   6653 C  CA  . SER D 1 28  ? 13.298  5.485   -31.010 1.00 4.90  ? 28  SER D CA  1 
ATOM   6654 C  C   . SER D 1 28  ? 13.809  5.480   -32.425 1.00 5.10  ? 28  SER D C   1 
ATOM   6655 O  O   . SER D 1 28  ? 14.130  6.535   -33.027 1.00 4.48  ? 28  SER D O   1 
ATOM   6656 C  CB  . SER D 1 28  ? 11.761  5.508   -31.070 1.00 5.56  ? 28  SER D CB  1 
ATOM   6657 O  OG  . SER D 1 28  ? 11.232  5.413   -29.772 1.00 5.61  ? 28  SER D OG  1 
ATOM   6658 N  N   . PRO D 1 29  ? 13.905  4.331   -33.072 1.00 4.47  ? 29  PRO D N   1 
ATOM   6659 C  CA  . PRO D 1 29  ? 13.525  2.982   -32.555 1.00 4.78  ? 29  PRO D CA  1 
ATOM   6660 C  C   . PRO D 1 29  ? 14.646  2.385   -31.770 1.00 5.40  ? 29  PRO D C   1 
ATOM   6661 O  O   . PRO D 1 29  ? 15.712  2.949   -31.642 1.00 5.79  ? 29  PRO D O   1 
ATOM   6662 C  CB  . PRO D 1 29  ? 13.266  2.229   -33.924 1.00 5.40  ? 29  PRO D CB  1 
ATOM   6663 C  CG  . PRO D 1 29  ? 14.403  2.772   -34.819 1.00 5.33  ? 29  PRO D CG  1 
ATOM   6664 C  CD  . PRO D 1 29  ? 14.448  4.255   -34.465 1.00 4.95  ? 29  PRO D CD  1 
ATOM   6665 N  N   . ILE D 1 30  ? 14.411  1.176   -31.309 1.00 4.86  ? 30  ILE D N   1 
ATOM   6666 C  CA  . ILE D 1 30  ? 15.362  0.463   -30.459 1.00 6.52  ? 30  ILE D CA  1 
ATOM   6667 C  C   . ILE D 1 30  ? 15.355  -1.024  -30.870 1.00 5.95  ? 30  ILE D C   1 
ATOM   6668 O  O   . ILE D 1 30  ? 14.461  -1.506  -31.589 1.00 5.98  ? 30  ILE D O   1 
ATOM   6669 C  CB  . ILE D 1 30  ? 15.100  0.549   -28.962 1.00 6.38  ? 30  ILE D CB  1 
ATOM   6670 C  CG1 . ILE D 1 30  ? 13.658  0.050   -28.679 1.00 7.50  ? 30  ILE D CG1 1 
ATOM   6671 C  CG2 . ILE D 1 30  ? 15.275  2.045   -28.534 1.00 7.47  ? 30  ILE D CG2 1 
ATOM   6672 C  CD1 . ILE D 1 30  ? 13.405  -0.012  -27.197 1.00 9.61  ? 30  ILE D CD1 1 
ATOM   6673 N  N   . ASP D 1 31  ? 16.406  -1.681  -30.411 1.00 5.96  ? 31  ASP D N   1 
ATOM   6674 C  CA  . ASP D 1 31  ? 16.525  -3.118  -30.628 1.00 6.67  ? 31  ASP D CA  1 
ATOM   6675 C  C   . ASP D 1 31  ? 15.895  -3.826  -29.423 1.00 8.42  ? 31  ASP D C   1 
ATOM   6676 O  O   . ASP D 1 31  ? 16.295  -3.635  -28.294 1.00 9.52  ? 31  ASP D O   1 
ATOM   6677 C  CB  . ASP D 1 31  ? 17.977  -3.572  -30.752 1.00 7.89  ? 31  ASP D CB  1 
ATOM   6678 C  CG  . ASP D 1 31  ? 18.093  -5.093  -30.827 1.00 10.27 ? 31  ASP D CG  1 
ATOM   6679 O  OD1 . ASP D 1 31  ? 17.524  -5.702  -31.762 1.00 10.28 ? 31  ASP D OD1 1 
ATOM   6680 O  OD2 . ASP D 1 31  ? 18.721  -5.688  -29.925 1.00 13.16 ? 31  ASP D OD2 1 
ATOM   6681 N  N   . LEU D 1 32  ? 14.948  -4.653  -29.696 1.00 7.78  ? 32  LEU D N   1 
ATOM   6682 C  CA  . LEU D 1 32  ? 14.208  -5.374  -28.602 1.00 8.48  ? 32  LEU D CA  1 
ATOM   6683 C  C   . LEU D 1 32  ? 14.956  -6.680  -28.329 1.00 9.18  ? 32  LEU D C   1 
ATOM   6684 O  O   . LEU D 1 32  ? 14.935  -7.545  -29.190 1.00 10.45 ? 32  LEU D O   1 
ATOM   6685 C  CB  . LEU D 1 32  ? 12.776  -5.641  -29.105 1.00 8.28  ? 32  LEU D CB  1 
ATOM   6686 C  CG  . LEU D 1 32  ? 12.039  -4.304  -29.482 1.00 9.33  ? 32  LEU D CG  1 
ATOM   6687 C  CD1 . LEU D 1 32  ? 10.732  -4.755  -30.194 1.00 9.56  ? 32  LEU D CD1 1 
ATOM   6688 C  CD2 . LEU D 1 32  ? 11.737  -3.491  -28.238 1.00 11.99 ? 32  LEU D CD2 1 
ATOM   6689 N  N   . HIS D 1 33  ? 15.674  -6.754  -27.202 1.00 9.43  ? 33  HIS D N   1 
ATOM   6690 C  CA  . HIS D 1 33  ? 16.426  -7.983  -26.928 1.00 9.06  ? 33  HIS D CA  1 
ATOM   6691 C  C   . HIS D 1 33  ? 16.324  -8.302  -25.467 1.00 9.53  ? 33  HIS D C   1 
ATOM   6692 O  O   . HIS D 1 33  ? 16.041  -7.425  -24.628 1.00 9.86  ? 33  HIS D O   1 
ATOM   6693 C  CB  . HIS D 1 33  ? 17.928  -7.835  -27.379 1.00 10.16 ? 33  HIS D CB  1 
ATOM   6694 C  CG  . HIS D 1 33  ? 18.670  -6.751  -26.669 1.00 10.59 ? 33  HIS D CG  1 
ATOM   6695 N  ND1 . HIS D 1 33  ? 18.507  -5.409  -26.972 1.00 12.56 ? 33  HIS D ND1 1 
ATOM   6696 C  CD2 . HIS D 1 33  ? 19.603  -6.782  -25.616 1.00 13.09 ? 33  HIS D CD2 1 
ATOM   6697 C  CE1 . HIS D 1 33  ? 19.307  -4.656  -26.153 1.00 16.39 ? 33  HIS D CE1 1 
ATOM   6698 N  NE2 . HIS D 1 33  ? 19.946  -5.500  -25.319 1.00 16.40 ? 33  HIS D NE2 1 
ATOM   6699 N  N   . SER D 1 34  ? 16.641  -9.575  -25.137 1.00 10.80 ? 34  SER D N   1 
ATOM   6700 C  CA  . SER D 1 34  ? 16.294  -10.125 -23.800 1.00 13.03 ? 34  SER D CA  1 
ATOM   6701 C  C   . SER D 1 34  ? 16.778  -9.335  -22.625 1.00 11.99 ? 34  SER D C   1 
ATOM   6702 O  O   . SER D 1 34  ? 16.024  -9.183  -21.645 1.00 12.79 ? 34  SER D O   1 
ATOM   6703 C  CB  . SER D 1 34  ? 16.794  -11.585 -23.734 1.00 14.12 ? 34  SER D CB  1 
ATOM   6704 O  OG  . SER D 1 34  ? 18.203  -11.573 -23.839 1.00 19.11 ? 34  SER D OG  1 
ATOM   6705 N  N   . ASP D 1 35  ? 17.994  -8.825  -22.670 1.00 11.19 ? 35  ASP D N   1 
ATOM   6706 C  CA  . ASP D 1 35  ? 18.549  -8.146  -21.493 1.00 12.36 ? 35  ASP D CA  1 
ATOM   6707 C  C   . ASP D 1 35  ? 17.808  -6.962  -21.009 1.00 12.70 ? 35  ASP D C   1 
ATOM   6708 O  O   . ASP D 1 35  ? 17.964  -6.535  -19.869 1.00 15.19 ? 35  ASP D O   1 
ATOM   6709 C  CB  . ASP D 1 35  ? 19.977  -7.660  -21.808 1.00 16.00 ? 35  ASP D CB  1 
ATOM   6710 C  CG  . ASP D 1 35  ? 20.858  -8.722  -22.453 1.00 17.53 ? 35  ASP D CG  1 
ATOM   6711 O  OD1 . ASP D 1 35  ? 21.861  -9.094  -21.813 1.00 17.07 ? 35  ASP D OD1 1 
ATOM   6712 O  OD2 . ASP D 1 35  ? 20.599  -9.139  -23.604 1.00 19.81 ? 35  ASP D OD2 1 
ATOM   6713 N  N   . ILE D 1 36  ? 16.993  -6.336  -21.885 1.00 11.99 ? 36  ILE D N   1 
ATOM   6714 C  CA  . ILE D 1 36  ? 16.278  -5.102  -21.531 1.00 11.38 ? 36  ILE D CA  1 
ATOM   6715 C  C   . ILE D 1 36  ? 14.790  -5.302  -21.437 1.00 10.77 ? 36  ILE D C   1 
ATOM   6716 O  O   . ILE D 1 36  ? 14.059  -4.340  -21.259 1.00 11.59 ? 36  ILE D O   1 
ATOM   6717 C  CB  . ILE D 1 36  ? 16.680  -3.859  -22.411 1.00 13.52 ? 36  ILE D CB  1 
ATOM   6718 C  CG1 . ILE D 1 36  ? 16.512  -4.149  -23.895 1.00 14.53 ? 36  ILE D CG1 1 
ATOM   6719 C  CG2 . ILE D 1 36  ? 18.156  -3.478  -22.096 1.00 16.15 ? 36  ILE D CG2 1 
ATOM   6720 C  CD1 . ILE D 1 36  ? 15.102  -4.251  -24.295 1.00 15.71 ? 36  ILE D CD1 1 
ATOM   6721 N  N   . LEU D 1 37  ? 14.365  -6.563  -21.561 1.00 10.13 ? 37  LEU D N   1 
ATOM   6722 C  CA  . LEU D 1 37  ? 12.897  -6.850  -21.432 1.00 10.80 ? 37  LEU D CA  1 
ATOM   6723 C  C   . LEU D 1 37  ? 12.506  -7.118  -20.017 1.00 11.97 ? 37  LEU D C   1 
ATOM   6724 O  O   . LEU D 1 37  ? 13.273  -7.794  -19.267 1.00 14.59 ? 37  LEU D O   1 
ATOM   6725 C  CB  . LEU D 1 37  ? 12.500  -8.053  -22.262 1.00 11.16 ? 37  LEU D CB  1 
ATOM   6726 C  CG  . LEU D 1 37  ? 12.849  -7.886  -23.759 1.00 11.63 ? 37  LEU D CG  1 
ATOM   6727 C  CD1 . LEU D 1 37  ? 12.399  -9.137  -24.479 1.00 12.94 ? 37  LEU D CD1 1 
ATOM   6728 C  CD2 . LEU D 1 37  ? 12.162  -6.680  -24.445 1.00 12.04 ? 37  LEU D CD2 1 
ATOM   6729 N  N   . GLN D 1 38  ? 11.305  -6.664  -19.636 1.00 10.04 ? 38  GLN D N   1 
ATOM   6730 C  CA  . GLN D 1 38  ? 10.826  -7.022  -18.295 1.00 10.88 ? 38  GLN D CA  1 
ATOM   6731 C  C   . GLN D 1 38  ? 9.337   -7.166  -18.347 1.00 9.22  ? 38  GLN D C   1 
ATOM   6732 O  O   . GLN D 1 38  ? 8.596   -6.281  -18.787 1.00 9.19  ? 38  GLN D O   1 
ATOM   6733 C  CB  . GLN D 1 38  ? 11.178  -5.927  -17.378 1.00 12.99 ? 38  GLN D CB  1 
ATOM   6734 C  CG  . GLN D 1 38  ? 10.727  -6.301  -15.952 1.00 18.39 ? 38  GLN D CG  1 
ATOM   6735 C  CD  . GLN D 1 38  ? 11.290  -5.421  -14.929 1.00 22.07 ? 38  GLN D CD  1 
ATOM   6736 O  OE1 . GLN D 1 38  ? 12.465  -5.565  -14.570 1.00 29.58 ? 38  GLN D OE1 1 
ATOM   6737 N  NE2 . GLN D 1 38  ? 10.495  -4.482  -14.443 1.00 24.92 ? 38  GLN D NE2 1 
ATOM   6738 N  N   . TYR D 1 39  ? 8.827   -8.321  -17.910 1.00 8.66  ? 39  TYR D N   1 
ATOM   6739 C  CA  . TYR D 1 39  ? 7.389   -8.574  -17.869 1.00 7.95  ? 39  TYR D CA  1 
ATOM   6740 C  C   . TYR D 1 39  ? 6.744   -7.617  -16.902 1.00 8.40  ? 39  TYR D C   1 
ATOM   6741 O  O   . TYR D 1 39  ? 7.243   -7.354  -15.829 1.00 10.34 ? 39  TYR D O   1 
ATOM   6742 C  CB  . TYR D 1 39  ? 7.181   -10.063 -17.504 1.00 9.60  ? 39  TYR D CB  1 
ATOM   6743 C  CG  . TYR D 1 39  ? 5.701   -10.367 -17.218 1.00 11.54 ? 39  TYR D CG  1 
ATOM   6744 C  CD1 . TYR D 1 39  ? 4.763   -10.401 -18.200 1.00 12.62 ? 39  TYR D CD1 1 
ATOM   6745 C  CD2 . TYR D 1 39  ? 5.310   -10.571 -15.894 1.00 11.81 ? 39  TYR D CD2 1 
ATOM   6746 C  CE1 . TYR D 1 39  ? 3.428   -10.636 -17.956 1.00 13.45 ? 39  TYR D CE1 1 
ATOM   6747 C  CE2 . TYR D 1 39  ? 3.972   -10.806 -15.630 1.00 12.73 ? 39  TYR D CE2 1 
ATOM   6748 C  CZ  . TYR D 1 39  ? 3.059   -10.819 -16.604 1.00 12.17 ? 39  TYR D CZ  1 
ATOM   6749 O  OH  . TYR D 1 39  ? 1.677   -11.063 -16.406 1.00 16.17 ? 39  TYR D OH  1 
ATOM   6750 N  N   . ASP D 1 40  ? 5.585   -7.096  -17.317 1.00 8.65  ? 40  ASP D N   1 
ATOM   6751 C  CA  . ASP D 1 40  ? 4.835   -6.153  -16.463 1.00 9.98  ? 40  ASP D CA  1 
ATOM   6752 C  C   . ASP D 1 40  ? 3.400   -6.671  -16.598 1.00 9.63  ? 40  ASP D C   1 
ATOM   6753 O  O   . ASP D 1 40  ? 2.758   -6.688  -17.685 1.00 8.84  ? 40  ASP D O   1 
ATOM   6754 C  CB  . ASP D 1 40  ? 5.045   -4.751  -17.014 1.00 10.31 ? 40  ASP D CB  1 
ATOM   6755 C  CG  . ASP D 1 40  ? 4.286   -3.694  -16.234 1.00 13.84 ? 40  ASP D CG  1 
ATOM   6756 O  OD1 . ASP D 1 40  ? 3.514   -4.061  -15.323 1.00 11.49 ? 40  ASP D OD1 1 
ATOM   6757 O  OD2 . ASP D 1 40  ? 4.464   -2.495  -16.535 1.00 19.05 ? 40  ASP D OD2 1 
ATOM   6758 N  N   . ALA D 1 41  ? 2.842   -7.124  -15.419 1.00 8.88  ? 41  ALA D N   1 
ATOM   6759 C  CA  . ALA D 1 41  ? 1.436   -7.561  -15.381 1.00 10.29 ? 41  ALA D CA  1 
ATOM   6760 C  C   . ALA D 1 41  ? 0.414   -6.433  -15.492 1.00 10.91 ? 41  ALA D C   1 
ATOM   6761 O  O   . ALA D 1 41  ? -0.733  -6.731  -15.715 1.00 11.43 ? 41  ALA D O   1 
ATOM   6762 C  CB  . ALA D 1 41  ? 1.200   -8.276  -14.029 1.00 11.23 ? 41  ALA D CB  1 
ATOM   6763 N  N   . SER D 1 42  ? 0.884   -5.185  -15.460 1.00 10.84 ? 42  SER D N   1 
ATOM   6764 C  CA  . SER D 1 42  ? -0.034  -4.039  -15.648 1.00 13.65 ? 42  SER D CA  1 
ATOM   6765 C  C   . SER D 1 42  ? -0.374  -3.872  -17.122 1.00 14.32 ? 42  SER D C   1 
ATOM   6766 O  O   . SER D 1 42  ? -1.258  -3.028  -17.450 1.00 16.24 ? 42  SER D O   1 
ATOM   6767 C  CB  . SER D 1 42  ? 0.544   -2.770  -14.979 1.00 15.44 ? 42  SER D CB  1 
ATOM   6768 O  OG  . SER D 1 42  ? 1.537   -2.240  -15.848 1.00 20.32 ? 42  SER D OG  1 
ATOM   6769 N  N   . LEU D 1 43  ? 0.309   -4.594  -18.023 1.00 11.70 ? 43  LEU D N   1 
ATOM   6770 C  CA  . LEU D 1 43  ? 0.090   -4.406  -19.478 1.00 12.91 ? 43  LEU D CA  1 
ATOM   6771 C  C   . LEU D 1 43  ? -1.002  -5.291  -19.937 1.00 12.68 ? 43  LEU D C   1 
ATOM   6772 O  O   . LEU D 1 43  ? -0.827  -6.351  -20.495 1.00 12.87 ? 43  LEU D O   1 
ATOM   6773 C  CB  . LEU D 1 43  ? 1.420   -4.651  -20.202 1.00 11.86 ? 43  LEU D CB  1 
ATOM   6774 C  CG  . LEU D 1 43  ? 2.535   -3.716  -19.884 1.00 13.19 ? 43  LEU D CG  1 
ATOM   6775 C  CD1 . LEU D 1 43  ? 3.721   -4.133  -20.752 1.00 13.42 ? 43  LEU D CD1 1 
ATOM   6776 C  CD2 . LEU D 1 43  ? 2.246   -2.225  -20.031 1.00 17.14 ? 43  LEU D CD2 1 
ATOM   6777 N  N   . THR D 1 44  ? -2.245  -4.754  -19.852 1.00 15.11 ? 44  THR D N   1 
ATOM   6778 C  CA  . THR D 1 44  ? -3.429  -5.532  -20.232 1.00 15.01 ? 44  THR D CA  1 
ATOM   6779 C  C   . THR D 1 44  ? -3.778  -5.247  -21.687 1.00 13.70 ? 44  THR D C   1 
ATOM   6780 O  O   . THR D 1 44  ? -3.154  -4.396  -22.334 1.00 13.01 ? 44  THR D O   1 
ATOM   6781 C  CB  . THR D 1 44  ? -4.589  -5.078  -19.311 1.00 16.79 ? 44  THR D CB  1 
ATOM   6782 O  OG1 . THR D 1 44  ? -4.595  -3.690  -19.369 1.00 20.52 ? 44  THR D OG1 1 
ATOM   6783 C  CG2 . THR D 1 44  ? -4.186  -5.517  -17.877 1.00 20.13 ? 44  THR D CG2 1 
ATOM   6784 N  N   . PRO D 1 45  ? -4.693  -5.974  -22.251 1.00 14.55 ? 45  PRO D N   1 
ATOM   6785 C  CA  . PRO D 1 45  ? -4.897  -5.929  -23.703 1.00 13.84 ? 45  PRO D CA  1 
ATOM   6786 C  C   . PRO D 1 45  ? -5.476  -4.604  -24.185 1.00 15.24 ? 45  PRO D C   1 
ATOM   6787 O  O   . PRO D 1 45  ? -6.360  -4.043  -23.538 1.00 18.66 ? 45  PRO D O   1 
ATOM   6788 C  CB  . PRO D 1 45  ? -5.858  -7.107  -23.929 1.00 14.62 ? 45  PRO D CB  1 
ATOM   6789 C  CG  . PRO D 1 45  ? -5.546  -8.022  -22.796 1.00 14.69 ? 45  PRO D CG  1 
ATOM   6790 C  CD  . PRO D 1 45  ? -5.330  -7.151  -21.621 1.00 14.69 ? 45  PRO D CD  1 
ATOM   6791 N  N   . LEU D 1 46  ? -4.921  -4.051  -25.255 1.00 13.75 ? 46  LEU D N   1 
ATOM   6792 C  CA  . LEU D 1 46  ? -5.544  -2.888  -25.877 1.00 13.34 ? 46  LEU D CA  1 
ATOM   6793 C  C   . LEU D 1 46  ? -6.837  -3.259  -26.530 1.00 11.99 ? 46  LEU D C   1 
ATOM   6794 O  O   . LEU D 1 46  ? -7.020  -4.441  -26.960 1.00 13.06 ? 46  LEU D O   1 
ATOM   6795 C  CB  . LEU D 1 46  ? -4.656  -2.316  -26.943 1.00 15.54 ? 46  LEU D CB  1 
ATOM   6796 C  CG  . LEU D 1 46  ? -3.329  -1.688  -26.410 1.00 18.36 ? 46  LEU D CG  1 
ATOM   6797 C  CD1 . LEU D 1 46  ? -2.475  -1.318  -27.643 1.00 22.89 ? 46  LEU D CD1 1 
ATOM   6798 C  CD2 . LEU D 1 46  ? -3.589  -0.518  -25.456 1.00 21.98 ? 46  LEU D CD2 1 
ATOM   6799 N  N   . GLU D 1 47  ? -7.736  -2.270  -26.587 1.00 12.76 ? 47  GLU D N   1 
ATOM   6800 C  CA  . GLU D 1 47  ? -8.905  -2.475  -27.360 1.00 13.96 ? 47  GLU D CA  1 
ATOM   6801 C  C   . GLU D 1 47  ? -8.932  -1.478  -28.539 1.00 13.59 ? 47  GLU D C   1 
ATOM   6802 O  O   . GLU D 1 47  ? -8.559  -0.328  -28.369 1.00 12.67 ? 47  GLU D O   1 
ATOM   6803 C  CB  . GLU D 1 47  ? -10.196 -2.400  -26.514 1.00 21.29 ? 47  GLU D CB  1 
ATOM   6804 C  CG  . GLU D 1 47  ? -10.743 -3.808  -26.136 1.00 31.48 ? 47  GLU D CG  1 
ATOM   6805 C  CD  . GLU D 1 47  ? -11.780 -3.783  -24.981 1.00 42.34 ? 47  GLU D CD  1 
ATOM   6806 O  OE1 . GLU D 1 47  ? -11.841 -2.764  -24.229 1.00 53.74 ? 47  GLU D OE1 1 
ATOM   6807 O  OE2 . GLU D 1 47  ? -12.537 -4.780  -24.812 1.00 49.19 ? 47  GLU D OE2 1 
ATOM   6808 N  N   . PHE D 1 48  ? -9.303  -1.973  -29.685 1.00 12.29 ? 48  PHE D N   1 
ATOM   6809 C  CA  . PHE D 1 48  ? -9.154  -1.202  -30.958 1.00 13.34 ? 48  PHE D CA  1 
ATOM   6810 C  C   . PHE D 1 48  ? -10.534 -0.838  -31.310 1.00 14.32 ? 48  PHE D C   1 
ATOM   6811 O  O   . PHE D 1 48  ? -11.297 -1.740  -31.697 1.00 17.30 ? 48  PHE D O   1 
ATOM   6812 C  CB  . PHE D 1 48  ? -8.466  -2.026  -32.037 1.00 12.37 ? 48  PHE D CB  1 
ATOM   6813 C  CG  . PHE D 1 48  ? -7.136  -2.553  -31.575 1.00 12.70 ? 48  PHE D CG  1 
ATOM   6814 C  CD1 . PHE D 1 48  ? -6.016  -1.744  -31.351 1.00 12.47 ? 48  PHE D CD1 1 
ATOM   6815 C  CD2 . PHE D 1 48  ? -7.060  -3.924  -31.249 1.00 13.59 ? 48  PHE D CD2 1 
ATOM   6816 C  CE1 . PHE D 1 48  ? -4.842  -2.288  -30.819 1.00 14.27 ? 48  PHE D CE1 1 
ATOM   6817 C  CE2 . PHE D 1 48  ? -5.880  -4.482  -30.764 1.00 14.50 ? 48  PHE D CE2 1 
ATOM   6818 C  CZ  . PHE D 1 48  ? -4.762  -3.677  -30.582 1.00 13.05 ? 48  PHE D CZ  1 
ATOM   6819 N  N   . GLN D 1 49  ? -10.937 0.414   -31.101 1.00 11.29 ? 49  GLN D N   1 
ATOM   6820 C  CA  . GLN D 1 49  ? -12.341 0.824   -31.235 1.00 12.89 ? 49  GLN D CA  1 
ATOM   6821 C  C   . GLN D 1 49  ? -12.484 1.680   -32.485 1.00 10.64 ? 49  GLN D C   1 
ATOM   6822 O  O   . GLN D 1 49  ? -11.675 2.555   -32.790 1.00 9.96  ? 49  GLN D O   1 
ATOM   6823 C  CB  . GLN D 1 49  ? -12.782 1.691   -30.056 1.00 17.33 ? 49  GLN D CB  1 
ATOM   6824 C  CG  . GLN D 1 49  ? -12.512 1.187   -28.605 1.00 24.40 ? 49  GLN D CG  1 
ATOM   6825 C  CD  . GLN D 1 49  ? -13.252 -0.080  -28.094 1.00 36.75 ? 49  GLN D CD  1 
ATOM   6826 O  OE1 . GLN D 1 49  ? -13.161 -0.414  -26.875 1.00 39.54 ? 49  GLN D OE1 1 
ATOM   6827 N  NE2 . GLN D 1 49  ? -13.942 -0.804  -28.989 1.00 40.05 ? 49  GLN D NE2 1 
ATOM   6828 N  N   . GLY D 1 50  ? -13.471 1.406   -33.314 1.00 10.05 ? 50  GLY D N   1 
ATOM   6829 C  CA  . GLY D 1 50  ? -13.718 2.216   -34.485 1.00 9.62  ? 50  GLY D CA  1 
ATOM   6830 C  C   . GLY D 1 50  ? -12.720 1.956   -35.621 1.00 8.12  ? 50  GLY D C   1 
ATOM   6831 O  O   . GLY D 1 50  ? -12.668 2.736   -36.557 1.00 10.10 ? 50  GLY D O   1 
ATOM   6832 N  N   . TYR D 1 51  ? -12.007 0.828   -35.481 1.00 7.92  ? 51  TYR D N   1 
ATOM   6833 C  CA  . TYR D 1 51  ? -11.064 0.443   -36.570 1.00 7.59  ? 51  TYR D CA  1 
ATOM   6834 C  C   . TYR D 1 51  ? -11.732 -0.118  -37.830 1.00 7.64  ? 51  TYR D C   1 
ATOM   6835 O  O   . TYR D 1 51  ? -11.135 -0.200  -38.903 1.00 7.50  ? 51  TYR D O   1 
ATOM   6836 C  CB  . TYR D 1 51  ? -10.073 -0.624  -36.073 1.00 7.51  ? 51  TYR D CB  1 
ATOM   6837 C  CG  . TYR D 1 51  ? -8.850  -0.062  -35.386 1.00 7.45  ? 51  TYR D CG  1 
ATOM   6838 C  CD1 . TYR D 1 51  ? -7.577  -0.527  -35.696 1.00 7.96  ? 51  TYR D CD1 1 
ATOM   6839 C  CD2 . TYR D 1 51  ? -8.967  0.931   -34.425 1.00 7.77  ? 51  TYR D CD2 1 
ATOM   6840 C  CE1 . TYR D 1 51  ? -6.457  -0.015  -35.069 1.00 7.62  ? 51  TYR D CE1 1 
ATOM   6841 C  CE2 . TYR D 1 51  ? -7.854  1.449   -33.792 1.00 7.98  ? 51  TYR D CE2 1 
ATOM   6842 C  CZ  . TYR D 1 51  ? -6.602  0.973   -34.117 1.00 8.37  ? 51  TYR D CZ  1 
ATOM   6843 O  OH  . TYR D 1 51  ? -5.495  1.490   -33.485 1.00 9.70  ? 51  TYR D OH  1 
ATOM   6844 N  N   . ASN D 1 52  ? -13.034 -0.535  -37.730 1.00 9.49  ? 52  ASN D N   1 
ATOM   6845 C  CA  . ASN D 1 52  ? -13.670 -1.071  -38.912 1.00 9.25  ? 52  ASN D CA  1 
ATOM   6846 C  C   . ASN D 1 52  ? -14.266 0.031   -39.796 1.00 10.70 ? 52  ASN D C   1 
ATOM   6847 O  O   . ASN D 1 52  ? -15.441 0.408   -39.622 1.00 12.40 ? 52  ASN D O   1 
ATOM   6848 C  CB  . ASN D 1 52  ? -14.716 -2.069  -38.464 1.00 11.21 ? 52  ASN D CB  1 
ATOM   6849 C  CG  . ASN D 1 52  ? -15.350 -2.815  -39.630 1.00 13.89 ? 52  ASN D CG  1 
ATOM   6850 O  OD1 . ASN D 1 52  ? -15.049 -2.585  -40.762 1.00 17.22 ? 52  ASN D OD1 1 
ATOM   6851 N  ND2 . ASN D 1 52  ? -16.264 -3.714  -39.321 1.00 18.80 ? 52  ASN D ND2 1 
ATOM   6852 N  N   . LEU D 1 53  ? -13.465 0.570   -40.691 1.00 8.83  ? 53  LEU D N   1 
ATOM   6853 C  CA  . LEU D 1 53  ? -13.914 1.733   -41.469 1.00 8.84  ? 53  LEU D CA  1 
ATOM   6854 C  C   . LEU D 1 53  ? -14.831 1.299   -42.597 1.00 9.82  ? 53  LEU D C   1 
ATOM   6855 O  O   . LEU D 1 53  ? -14.620 0.250   -43.270 1.00 11.81 ? 53  LEU D O   1 
ATOM   6856 C  CB  . LEU D 1 53  ? -12.685 2.508   -42.006 1.00 9.42  ? 53  LEU D CB  1 
ATOM   6857 C  CG  . LEU D 1 53  ? -11.642 2.872   -40.940 1.00 10.29 ? 53  LEU D CG  1 
ATOM   6858 C  CD1 . LEU D 1 53  ? -10.487 3.556   -41.688 1.00 12.73 ? 53  LEU D CD1 1 
ATOM   6859 C  CD2 . LEU D 1 53  ? -12.192 3.808   -39.891 1.00 11.80 ? 53  LEU D CD2 1 
ATOM   6860 N  N   . SER D 1 54  ? -15.878 2.091   -42.796 1.00 9.66  ? 54  SER D N   1 
ATOM   6861 C  CA  . SER D 1 54  ? -16.808 1.742   -43.821 1.00 9.97  ? 54  SER D CA  1 
ATOM   6862 C  C   . SER D 1 54  ? -16.261 1.717   -45.238 1.00 10.33 ? 54  SER D C   1 
ATOM   6863 O  O   . SER D 1 54  ? -15.618 2.689   -45.649 1.00 10.24 ? 54  SER D O   1 
ATOM   6864 C  CB  . SER D 1 54  ? -17.964 2.771   -43.775 1.00 10.23 ? 54  SER D CB  1 
ATOM   6865 O  OG  . SER D 1 54  ? -18.917 2.400   -44.804 1.00 12.06 ? 54  SER D OG  1 
ATOM   6866 N  N   . ALA D 1 55  ? -16.591 0.680   -45.976 1.00 11.92 ? 55  ALA D N   1 
ATOM   6867 C  CA  . ALA D 1 55  ? -16.123 0.641   -47.361 1.00 13.01 ? 55  ALA D CA  1 
ATOM   6868 C  C   . ALA D 1 55  ? -16.773 1.644   -48.288 1.00 13.19 ? 55  ALA D C   1 
ATOM   6869 O  O   . ALA D 1 55  ? -16.331 1.854   -49.424 1.00 15.91 ? 55  ALA D O   1 
ATOM   6870 C  CB  . ALA D 1 55  ? -16.361 -0.761  -47.943 1.00 16.80 ? 55  ALA D CB  1 
ATOM   6871 N  N   . ASN D 1 56  ? -17.791 2.328   -47.792 1.00 11.75 ? 56  ASN D N   1 
ATOM   6872 C  CA  . ASN D 1 56  ? -18.436 3.430   -48.569 1.00 13.33 ? 56  ASN D CA  1 
ATOM   6873 C  C   . ASN D 1 56  ? -17.939 4.774   -48.203 1.00 13.23 ? 56  ASN D C   1 
ATOM   6874 O  O   . ASN D 1 56  ? -18.403 5.769   -48.749 1.00 16.01 ? 56  ASN D O   1 
ATOM   6875 C  CB  . ASN D 1 56  ? -19.957 3.399   -48.296 1.00 15.00 ? 56  ASN D CB  1 
ATOM   6876 C  CG  . ASN D 1 56  ? -20.608 2.187   -48.920 1.00 24.24 ? 56  ASN D CG  1 
ATOM   6877 O  OD1 . ASN D 1 56  ? -20.191 1.700   -49.989 1.00 23.59 ? 56  ASN D OD1 1 
ATOM   6878 N  ND2 . ASN D 1 56  ? -21.667 1.676   -48.252 1.00 27.09 ? 56  ASN D ND2 1 
ATOM   6879 N  N   . LYS D 1 57  ? -16.971 4.828   -47.322 1.00 11.21 ? 57  LYS D N   1 
ATOM   6880 C  CA  . LYS D 1 57  ? -16.246 6.066   -46.948 1.00 11.25 ? 57  LYS D CA  1 
ATOM   6881 C  C   . LYS D 1 57  ? -14.832 5.938   -47.536 1.00 10.32 ? 57  LYS D C   1 
ATOM   6882 O  O   . LYS D 1 57  ? -14.442 4.850   -47.995 1.00 12.63 ? 57  LYS D O   1 
ATOM   6883 C  CB  . LYS D 1 57  ? -16.169 6.276   -45.447 1.00 13.75 ? 57  LYS D CB  1 
ATOM   6884 C  CG  . LYS D 1 57  ? -17.564 6.519   -44.830 1.00 16.80 ? 57  LYS D CG  1 
ATOM   6885 C  CD  . LYS D 1 57  ? -17.415 6.974   -43.383 1.00 23.01 ? 57  LYS D CD  1 
ATOM   6886 C  CE  . LYS D 1 57  ? -18.710 7.667   -42.942 1.00 26.12 ? 57  LYS D CE  1 
ATOM   6887 N  NZ  . LYS D 1 57  ? -18.567 8.032   -41.491 1.00 33.05 ? 57  LYS D NZ  1 
ATOM   6888 N  N   . GLN D 1 58  ? -14.197 7.094   -47.688 1.00 11.20 ? 58  GLN D N   1 
ATOM   6889 C  CA  . GLN D 1 58  ? -12.839 7.039   -48.268 1.00 13.11 ? 58  GLN D CA  1 
ATOM   6890 C  C   . GLN D 1 58  ? -11.921 7.914   -47.462 1.00 10.66 ? 58  GLN D C   1 
ATOM   6891 O  O   . GLN D 1 58  ? -12.290 8.855   -46.790 1.00 12.39 ? 58  GLN D O   1 
ATOM   6892 C  CB  . GLN D 1 58  ? -12.815 7.370   -49.741 1.00 19.18 ? 58  GLN D CB  1 
ATOM   6893 C  CG  . GLN D 1 58  ? -13.394 8.674   -50.025 1.00 20.52 ? 58  GLN D CG  1 
ATOM   6894 C  CD  . GLN D 1 58  ? -13.546 8.938   -51.545 1.00 23.39 ? 58  GLN D CD  1 
ATOM   6895 O  OE1 . GLN D 1 58  ? -13.273 8.077   -52.424 1.00 21.32 ? 58  GLN D OE1 1 
ATOM   6896 N  NE2 . GLN D 1 58  ? -13.947 10.156  -51.836 1.00 26.67 ? 58  GLN D NE2 1 
ATOM   6897 N  N   . PHE D 1 59  ? -10.683 7.483   -47.458 1.00 9.10  ? 59  PHE D N   1 
ATOM   6898 C  CA  . PHE D 1 59  ? -9.614  8.062   -46.628 1.00 8.45  ? 59  PHE D CA  1 
ATOM   6899 C  C   . PHE D 1 59  ? -8.470  8.447   -47.509 1.00 9.09  ? 59  PHE D C   1 
ATOM   6900 O  O   . PHE D 1 59  ? -8.076  7.747   -48.428 1.00 9.91  ? 59  PHE D O   1 
ATOM   6901 C  CB  . PHE D 1 59  ? -9.241  6.994   -45.577 1.00 7.75  ? 59  PHE D CB  1 
ATOM   6902 C  CG  . PHE D 1 59  ? -10.436 6.650   -44.743 1.00 8.14  ? 59  PHE D CG  1 
ATOM   6903 C  CD1 . PHE D 1 59  ? -11.378 5.674   -45.183 1.00 8.29  ? 59  PHE D CD1 1 
ATOM   6904 C  CD2 . PHE D 1 59  ? -10.789 7.461   -43.630 1.00 8.35  ? 59  PHE D CD2 1 
ATOM   6905 C  CE1 . PHE D 1 59  ? -12.587 5.460   -44.448 1.00 8.04  ? 59  PHE D CE1 1 
ATOM   6906 C  CE2 . PHE D 1 59  ? -11.929 7.187   -42.913 1.00 8.35  ? 59  PHE D CE2 1 
ATOM   6907 C  CZ  . PHE D 1 59  ? -12.853 6.243   -43.345 1.00 8.55  ? 59  PHE D CZ  1 
ATOM   6908 N  N   . LEU D 1 60  ? -7.876  9.572   -47.185 1.00 8.86  ? 60  LEU D N   1 
ATOM   6909 C  CA  . LEU D 1 60  ? -6.863  10.145  -48.056 1.00 10.27 ? 60  LEU D CA  1 
ATOM   6910 C  C   . LEU D 1 60  ? -5.501  9.540   -47.831 1.00 9.78  ? 60  LEU D C   1 
ATOM   6911 O  O   . LEU D 1 60  ? -4.971  9.582   -46.710 1.00 9.91  ? 60  LEU D O   1 
ATOM   6912 C  CB  . LEU D 1 60  ? -6.795  11.627  -47.709 1.00 12.16 ? 60  LEU D CB  1 
ATOM   6913 C  CG  . LEU D 1 60  ? -6.090  12.516  -48.757 1.00 15.31 ? 60  LEU D CG  1 
ATOM   6914 C  CD1 . LEU D 1 60  ? -6.797  12.480  -50.109 1.00 15.81 ? 60  LEU D CD1 1 
ATOM   6915 C  CD2 . LEU D 1 60  ? -6.027  13.917  -48.159 1.00 18.87 ? 60  LEU D CD2 1 
ATOM   6916 N  N   . LEU D 1 61  ? -4.897  9.047   -48.865 1.00 9.02  ? 61  LEU D N   1 
ATOM   6917 C  CA  . LEU D 1 61  ? -3.479  8.611   -48.910 1.00 10.17 ? 61  LEU D CA  1 
ATOM   6918 C  C   . LEU D 1 61  ? -2.652  9.733   -49.517 1.00 11.55 ? 61  LEU D C   1 
ATOM   6919 O  O   . LEU D 1 61  ? -3.013  10.286  -50.575 1.00 12.16 ? 61  LEU D O   1 
ATOM   6920 C  CB  . LEU D 1 61  ? -3.401  7.330   -49.714 1.00 10.99 ? 61  LEU D CB  1 
ATOM   6921 C  CG  . LEU D 1 61  ? -2.108  6.510   -49.784 1.00 11.38 ? 61  LEU D CG  1 
ATOM   6922 C  CD1 . LEU D 1 61  ? -1.864  5.737   -48.493 1.00 11.07 ? 61  LEU D CD1 1 
ATOM   6923 C  CD2 . LEU D 1 61  ? -2.118  5.483   -50.894 1.00 12.39 ? 61  LEU D CD2 1 
ATOM   6924 N  N   . THR D 1 62  ? -1.555  10.103  -48.859 1.00 11.93 ? 62  THR D N   1 
ATOM   6925 C  CA  . THR D 1 62  ? -0.759  11.288  -49.302 1.00 11.84 ? 62  THR D CA  1 
ATOM   6926 C  C   . THR D 1 62  ? 0.723   10.853  -49.282 1.00 13.58 ? 62  THR D C   1 
ATOM   6927 O  O   . THR D 1 62  ? 1.203   10.253  -48.313 1.00 14.33 ? 62  THR D O   1 
ATOM   6928 C  CB  . THR D 1 62  ? -0.855  12.458  -48.356 1.00 14.40 ? 62  THR D CB  1 
ATOM   6929 O  OG1 . THR D 1 62  ? -2.192  12.919  -48.286 1.00 19.55 ? 62  THR D OG1 1 
ATOM   6930 C  CG2 . THR D 1 62  ? -0.010  13.712  -48.831 1.00 18.20 ? 62  THR D CG2 1 
ATOM   6931 N  N   . ASN D 1 63  ? 1.497   11.291  -50.253 1.00 12.27 ? 63  ASN D N   1 
ATOM   6932 C  CA  . ASN D 1 63  ? 2.983   11.293  -50.183 1.00 13.21 ? 63  ASN D CA  1 
ATOM   6933 C  C   . ASN D 1 63  ? 3.402   12.703  -49.786 1.00 12.81 ? 63  ASN D C   1 
ATOM   6934 O  O   . ASN D 1 63  ? 3.165   13.656  -50.475 1.00 13.40 ? 63  ASN D O   1 
ATOM   6935 C  CB  . ASN D 1 63  ? 3.467   10.965  -51.609 1.00 13.57 ? 63  ASN D CB  1 
ATOM   6936 C  CG  . ASN D 1 63  ? 4.986   10.934  -51.719 1.00 11.41 ? 63  ASN D CG  1 
ATOM   6937 O  OD1 . ASN D 1 63  ? 5.651   11.579  -50.890 1.00 11.97 ? 63  ASN D OD1 1 
ATOM   6938 N  ND2 . ASN D 1 63  ? 5.502   10.202  -52.658 1.00 10.46 ? 63  ASN D ND2 1 
ATOM   6939 N  N   . ASN D 1 64  ? 4.004   12.879  -48.584 1.00 17.31 ? 64  ASN D N   1 
ATOM   6940 C  CA  . ASN D 1 64  ? 4.440   14.228  -48.152 1.00 18.58 ? 64  ASN D CA  1 
ATOM   6941 C  C   . ASN D 1 64  ? 5.932   14.376  -48.361 1.00 20.19 ? 64  ASN D C   1 
ATOM   6942 O  O   . ASN D 1 64  ? 6.547   15.329  -47.834 1.00 22.88 ? 64  ASN D O   1 
ATOM   6943 C  CB  . ASN D 1 64  ? 4.114   14.551  -46.675 1.00 19.72 ? 64  ASN D CB  1 
ATOM   6944 C  CG  . ASN D 1 64  ? 4.849   13.654  -45.695 1.00 22.39 ? 64  ASN D CG  1 
ATOM   6945 O  OD1 . ASN D 1 64  ? 5.877   13.064  -45.996 1.00 20.75 ? 64  ASN D OD1 1 
ATOM   6946 N  ND2 . ASN D 1 64  ? 4.293   13.545  -44.473 1.00 24.60 ? 64  ASN D ND2 1 
ATOM   6947 N  N   . GLY D 1 65  ? 6.525   13.403  -49.064 1.00 16.20 ? 65  GLY D N   1 
ATOM   6948 C  CA  . GLY D 1 65  ? 7.960   13.551  -49.367 1.00 17.39 ? 65  GLY D CA  1 
ATOM   6949 C  C   . GLY D 1 65  ? 8.905   12.796  -48.462 1.00 20.75 ? 65  GLY D C   1 
ATOM   6950 O  O   . GLY D 1 65  ? 10.108  12.639  -48.739 1.00 21.80 ? 65  GLY D O   1 
ATOM   6951 N  N   . HIS D 1 66  ? 8.416   12.324  -47.332 1.00 21.57 ? 66  HIS D N   1 
ATOM   6952 C  CA  . HIS D 1 66  ? 9.295   11.697  -46.363 1.00 20.43 ? 66  HIS D CA  1 
ATOM   6953 C  C   . HIS D 1 66  ? 8.717   10.372  -46.108 1.00 15.27 ? 66  HIS D C   1 
ATOM   6954 O  O   . HIS D 1 66  ? 9.290   9.354   -45.802 1.00 21.77 ? 66  HIS D O   1 
ATOM   6955 C  CB  . HIS D 1 66  ? 9.300   12.586  -45.054 1.00 15.95 ? 66  HIS D CB  1 
ATOM   6956 C  CG  . HIS D 1 66  ? 10.060  13.857  -45.175 1.00 18.45 ? 66  HIS D CG  1 
ATOM   6957 N  ND1 . HIS D 1 66  ? 11.376  13.874  -45.427 1.00 15.74 ? 66  HIS D ND1 1 
ATOM   6958 C  CD2 . HIS D 1 66  ? 9.693   15.115  -44.978 1.00 14.44 ? 66  HIS D CD2 1 
ATOM   6959 C  CE1 . HIS D 1 66  ? 11.820  15.139  -45.421 1.00 18.05 ? 66  HIS D CE1 1 
ATOM   6960 N  NE2 . HIS D 1 66  ? 10.771  15.919  -45.164 1.00 22.00 ? 66  HIS D NE2 1 
ATOM   6961 N  N   . SER D 1 67  ? 7.351   10.415  -46.246 1.00 19.64 ? 67  SER D N   1 
ATOM   6962 C  CA  . SER D 1 67  ? 6.682   9.135   -46.235 1.00 18.76 ? 67  SER D CA  1 
ATOM   6963 C  C   . SER D 1 67  ? 5.271   9.189   -46.978 1.00 18.95 ? 67  SER D C   1 
ATOM   6964 O  O   . SER D 1 67  ? 4.749   10.293  -47.350 1.00 22.77 ? 67  SER D O   1 
ATOM   6965 C  CB  . SER D 1 67  ? 6.627   8.330   -44.856 1.00 29.92 ? 67  SER D CB  1 
ATOM   6966 O  OG  . SER D 1 67  ? 5.335   8.341   -44.199 1.00 22.58 ? 67  SER D OG  1 
ATOM   6967 N  N   . VAL D 1 68  ? 4.697   7.985   -47.073 1.00 18.17 ? 68  VAL D N   1 
ATOM   6968 C  CA  . VAL D 1 68  ? 3.278   7.887   -47.575 1.00 15.43 ? 68  VAL D CA  1 
ATOM   6969 C  C   . VAL D 1 68  ? 2.352   7.519   -46.346 1.00 10.68 ? 68  VAL D C   1 
ATOM   6970 O  O   . VAL D 1 68  ? 2.584   6.518   -45.675 1.00 12.16 ? 68  VAL D O   1 
ATOM   6971 C  CB  . VAL D 1 68  ? 3.043   6.832   -48.694 1.00 17.72 ? 68  VAL D CB  1 
ATOM   6972 C  CG1 . VAL D 1 68  ? 3.415   5.421   -48.236 1.00 21.90 ? 68  VAL D CG1 1 
ATOM   6973 C  CG2 . VAL D 1 68  ? 1.578   6.838   -49.124 1.00 18.97 ? 68  VAL D CG2 1 
ATOM   6974 N  N   . LYS D 1 69  ? 1.359   8.372   -46.167 1.00 10.28 ? 69  LYS D N   1 
ATOM   6975 C  CA  . LYS D 1 69  ? 0.444   8.179   -45.003 1.00 9.40  ? 69  LYS D CA  1 
ATOM   6976 C  C   . LYS D 1 69  ? -0.974  8.046   -45.456 1.00 8.53  ? 69  LYS D C   1 
ATOM   6977 O  O   . LYS D 1 69  ? -1.391  8.658   -46.437 1.00 9.23  ? 69  LYS D O   1 
ATOM   6978 C  CB  . LYS D 1 69  ? 0.687   9.266   -43.988 1.00 13.16 ? 69  LYS D CB  1 
ATOM   6979 C  CG  . LYS D 1 69  ? 0.231   10.603  -44.487 1.00 18.68 ? 69  LYS D CG  1 
ATOM   6980 C  CD  . LYS D 1 69  ? 0.215   11.651  -43.383 1.00 23.98 ? 69  LYS D CD  1 
ATOM   6981 C  CE  . LYS D 1 69  ? -0.323  12.941  -43.987 1.00 27.95 ? 69  LYS D CE  1 
ATOM   6982 N  NZ  . LYS D 1 69  ? -0.050  14.093  -43.081 1.00 35.63 ? 69  LYS D NZ  1 
ATOM   6983 N  N   . LEU D 1 70  ? -1.745  7.310   -44.679 1.00 6.25  ? 70  LEU D N   1 
ATOM   6984 C  CA  . LEU D 1 70  ? -3.179  7.207   -44.825 1.00 6.61  ? 70  LEU D CA  1 
ATOM   6985 C  C   . LEU D 1 70  ? -3.798  7.928   -43.651 1.00 6.28  ? 70  LEU D C   1 
ATOM   6986 O  O   . LEU D 1 70  ? -3.550  7.613   -42.500 1.00 6.56  ? 70  LEU D O   1 
ATOM   6987 C  CB  . LEU D 1 70  ? -3.574  5.729   -44.859 1.00 6.94  ? 70  LEU D CB  1 
ATOM   6988 C  CG  . LEU D 1 70  ? -5.104  5.496   -45.015 1.00 6.50  ? 70  LEU D CG  1 
ATOM   6989 C  CD1 . LEU D 1 70  ? -5.550  5.983   -46.416 1.00 8.19  ? 70  LEU D CD1 1 
ATOM   6990 C  CD2 . LEU D 1 70  ? -5.451  4.016   -44.768 1.00 9.37  ? 70  LEU D CD2 1 
ATOM   6991 N  N   . ASN D 1 71  ? -4.616  8.930   -43.950 1.00 6.81  ? 71  ASN D N   1 
ATOM   6992 C  CA  . ASN D 1 71  ? -5.347  9.632   -42.873 1.00 7.65  ? 71  ASN D CA  1 
ATOM   6993 C  C   . ASN D 1 71  ? -6.387  8.789   -42.281 1.00 8.45  ? 71  ASN D C   1 
ATOM   6994 O  O   . ASN D 1 71  ? -7.059  8.034   -42.988 1.00 10.67 ? 71  ASN D O   1 
ATOM   6995 C  CB  . ASN D 1 71  ? -5.973  10.901  -43.468 1.00 11.42 ? 71  ASN D CB  1 
ATOM   6996 C  CG  . ASN D 1 71  ? -4.994  12.010  -43.649 1.00 15.28 ? 71  ASN D CG  1 
ATOM   6997 O  OD1 . ASN D 1 71  ? -3.847  11.953  -43.313 1.00 21.91 ? 71  ASN D OD1 1 
ATOM   6998 N  ND2 . ASN D 1 71  ? -5.539  13.131  -44.093 1.00 20.12 ? 71  ASN D ND2 1 
ATOM   6999 N  N   . LEU D 1 72  ? -6.549  8.866   -40.981 1.00 6.97  ? 72  LEU D N   1 
ATOM   7000 C  CA  . LEU D 1 72  ? -7.502  8.057   -40.241 1.00 7.66  ? 72  LEU D CA  1 
ATOM   7001 C  C   . LEU D 1 72  ? -8.434  8.987   -39.461 1.00 8.48  ? 72  LEU D C   1 
ATOM   7002 O  O   . LEU D 1 72  ? -8.003  10.077  -39.080 1.00 9.27  ? 72  LEU D O   1 
ATOM   7003 C  CB  . LEU D 1 72  ? -6.739  7.137   -39.275 1.00 7.18  ? 72  LEU D CB  1 
ATOM   7004 C  CG  . LEU D 1 72  ? -5.873  6.090   -39.978 1.00 7.77  ? 72  LEU D CG  1 
ATOM   7005 C  CD1 . LEU D 1 72  ? -4.952  5.467   -38.921 1.00 7.25  ? 72  LEU D CD1 1 
ATOM   7006 C  CD2 . LEU D 1 72  ? -6.732  5.091   -40.712 1.00 8.04  ? 72  LEU D CD2 1 
ATOM   7007 N  N   . PRO D 1 73  ? -9.634  8.556   -39.194 1.00 8.28  ? 73  PRO D N   1 
ATOM   7008 C  CA  . PRO D 1 73  ? -10.646 9.406   -38.482 1.00 9.96  ? 73  PRO D CA  1 
ATOM   7009 C  C   . PRO D 1 73  ? -10.460 9.352   -36.974 1.00 11.23 ? 73  PRO D C   1 
ATOM   7010 O  O   . PRO D 1 73  ? -10.017 8.345   -36.374 1.00 11.63 ? 73  PRO D O   1 
ATOM   7011 C  CB  . PRO D 1 73  ? -11.929 8.753   -38.909 1.00 9.58  ? 73  PRO D CB  1 
ATOM   7012 C  CG  . PRO D 1 73  ? -11.604 7.262   -39.020 1.00 8.95  ? 73  PRO D CG  1 
ATOM   7013 C  CD  . PRO D 1 73  ? -10.227 7.277   -39.656 1.00 8.66  ? 73  PRO D CD  1 
ATOM   7014 N  N   . SER D 1 74  ? -10.701 10.479  -36.300 1.00 13.72 ? 74  SER D N   1 
ATOM   7015 C  CA  . SER D 1 74  ? -10.470 10.535  -34.875 1.00 14.73 ? 74  SER D CA  1 
ATOM   7016 C  C   . SER D 1 74  ? -11.471 9.696   -34.042 1.00 16.30 ? 74  SER D C   1 
ATOM   7017 O  O   . SER D 1 74  ? -11.181 9.429   -32.860 1.00 15.73 ? 74  SER D O   1 
ATOM   7018 C  CB  . SER D 1 74  ? -10.438 12.023  -34.458 1.00 16.69 ? 74  SER D CB  1 
ATOM   7019 O  OG  . SER D 1 74  ? -11.749 12.588  -34.680 1.00 22.74 ? 74  SER D OG  1 
ATOM   7020 N  N   . ASP D 1 75  ? -12.549 9.242   -34.677 1.00 15.39 ? 75  ASP D N   1 
ATOM   7021 C  CA  . ASP D 1 75  ? -13.451 8.324   -34.028 1.00 19.35 ? 75  ASP D CA  1 
ATOM   7022 C  C   . ASP D 1 75  ? -12.768 6.940   -33.773 1.00 16.49 ? 75  ASP D C   1 
ATOM   7023 O  O   . ASP D 1 75  ? -13.216 6.121   -32.920 1.00 19.66 ? 75  ASP D O   1 
ATOM   7024 C  CB  . ASP D 1 75  ? -14.742 8.130   -34.878 1.00 23.84 ? 75  ASP D CB  1 
ATOM   7025 C  CG  . ASP D 1 75  ? -14.521 7.314   -36.167 1.00 33.21 ? 75  ASP D CG  1 
ATOM   7026 O  OD1 . ASP D 1 75  ? -13.720 6.363   -36.167 1.00 46.88 ? 75  ASP D OD1 1 
ATOM   7027 O  OD2 . ASP D 1 75  ? -15.196 7.612   -37.186 1.00 41.11 ? 75  ASP D OD2 1 
ATOM   7028 N  N   . MET D 1 76  ? -11.705 6.658   -34.511 1.00 12.49 ? 76  MET D N   1 
ATOM   7029 C  CA  . MET D 1 76  ? -10.948 5.429   -34.305 1.00 12.15 ? 76  MET D CA  1 
ATOM   7030 C  C   . MET D 1 76  ? -10.018 5.669   -33.146 1.00 10.18 ? 76  MET D C   1 
ATOM   7031 O  O   . MET D 1 76  ? -9.350  6.711   -33.064 1.00 9.89  ? 76  MET D O   1 
ATOM   7032 C  CB  . MET D 1 76  ? -10.219 5.183   -35.620 1.00 14.45 ? 76  MET D CB  1 
ATOM   7033 C  CG  . MET D 1 76  ? -9.387  3.987   -35.665 1.00 12.73 ? 76  MET D CG  1 
ATOM   7034 S  SD  . MET D 1 76  ? -8.678  3.936   -37.390 1.00 12.96 ? 76  MET D SD  1 
ATOM   7035 C  CE  . MET D 1 76  ? -7.322  2.871   -37.006 1.00 12.60 ? 76  MET D CE  1 
ATOM   7036 N  N   . HIS D 1 77  ? -10.007 4.744   -32.165 1.00 9.50  ? 77  HIS D N   1 
ATOM   7037 C  CA  . HIS D 1 77  ? -9.213  4.966   -30.978 1.00 10.49 ? 77  HIS D CA  1 
ATOM   7038 C  C   . HIS D 1 77  ? -8.739  3.822   -30.274 1.00 9.01  ? 77  HIS D C   1 
ATOM   7039 O  O   . HIS D 1 77  ? -9.285  2.737   -30.562 1.00 9.52  ? 77  HIS D O   1 
ATOM   7040 C  CB  . HIS D 1 77  ? -9.935  5.935   -30.034 1.00 15.09 ? 77  HIS D CB  1 
ATOM   7041 C  CG  . HIS D 1 77  ? -11.183 5.422   -29.459 1.00 17.72 ? 77  HIS D CG  1 
ATOM   7042 N  ND1 . HIS D 1 77  ? -12.380 5.405   -30.134 1.00 22.13 ? 77  HIS D ND1 1 
ATOM   7043 C  CD2 . HIS D 1 77  ? -11.439 4.945   -28.166 1.00 18.87 ? 77  HIS D CD2 1 
ATOM   7044 C  CE1 . HIS D 1 77  ? -13.352 4.889   -29.302 1.00 23.38 ? 77  HIS D CE1 1 
ATOM   7045 N  NE2 . HIS D 1 77  ? -12.789 4.662   -28.085 1.00 20.92 ? 77  HIS D NE2 1 
ATOM   7046 N  N   . ILE D 1 78  ? -7.774  3.960   -29.403 1.00 9.71  ? 78  ILE D N   1 
ATOM   7047 C  CA  . ILE D 1 78  ? -7.428  2.868   -28.600 1.00 11.69 ? 78  ILE D CA  1 
ATOM   7048 C  C   . ILE D 1 78  ? -7.858  3.126   -27.190 1.00 13.14 ? 78  ILE D C   1 
ATOM   7049 O  O   . ILE D 1 78  ? -7.668  4.282   -26.702 1.00 13.21 ? 78  ILE D O   1 
ATOM   7050 C  CB  . ILE D 1 78  ? -5.968  2.452   -28.749 1.00 15.07 ? 78  ILE D CB  1 
ATOM   7051 C  CG1 . ILE D 1 78  ? -4.968  3.544   -28.603 1.00 17.55 ? 78  ILE D CG1 1 
ATOM   7052 C  CG2 . ILE D 1 78  ? -5.742  1.779   -30.095 1.00 17.39 ? 78  ILE D CG2 1 
ATOM   7053 C  CD1 . ILE D 1 78  ? -3.611  3.055   -29.218 1.00 17.18 ? 78  ILE D CD1 1 
ATOM   7054 N  N   . GLN D 1 79  ? -8.250  2.046   -26.546 1.00 14.26 ? 79  GLN D N   1 
ATOM   7055 C  CA  . GLN D 1 79  ? -8.532  2.009   -25.108 1.00 18.11 ? 79  GLN D CA  1 
ATOM   7056 C  C   . GLN D 1 79  ? -7.621  1.090   -24.401 1.00 15.96 ? 79  GLN D C   1 
ATOM   7057 O  O   . GLN D 1 79  ? -7.181  0.054   -24.974 1.00 16.58 ? 79  GLN D O   1 
ATOM   7058 C  CB  . GLN D 1 79  ? -9.984  1.617   -24.838 1.00 24.06 ? 79  GLN D CB  1 
ATOM   7059 C  CG  . GLN D 1 79  ? -11.010 2.680   -25.238 1.00 29.77 ? 79  GLN D CG  1 
ATOM   7060 C  CD  . GLN D 1 79  ? -11.224 3.760   -24.179 1.00 41.26 ? 79  GLN D CD  1 
ATOM   7061 O  OE1 . GLN D 1 79  ? -10.464 4.756   -24.078 1.00 42.89 ? 79  GLN D OE1 1 
ATOM   7062 N  NE2 . GLN D 1 79  ? -12.289 3.581   -23.386 1.00 43.76 ? 79  GLN D NE2 1 
ATOM   7063 N  N   . GLY D 1 80  ? -7.238  1.457   -23.158 1.00 14.80 ? 80  GLY D N   1 
ATOM   7064 C  CA  . GLY D 1 80  ? -6.345  0.595   -22.416 1.00 17.03 ? 80  GLY D CA  1 
ATOM   7065 C  C   . GLY D 1 80  ? -5.057  1.239   -21.946 1.00 21.20 ? 80  GLY D C   1 
ATOM   7066 O  O   . GLY D 1 80  ? -4.148  0.558   -21.329 1.00 24.68 ? 80  GLY D O   1 
ATOM   7067 N  N   . LEU D 1 81  ? -4.852  2.512   -22.343 1.00 14.18 ? 81  LEU D N   1 
ATOM   7068 C  CA  . LEU D 1 81  ? -3.718  3.268   -21.854 1.00 14.60 ? 81  LEU D CA  1 
ATOM   7069 C  C   . LEU D 1 81  ? -4.221  4.272   -20.834 1.00 13.17 ? 81  LEU D C   1 
ATOM   7070 O  O   . LEU D 1 81  ? -5.394  4.204   -20.459 1.00 15.67 ? 81  LEU D O   1 
ATOM   7071 C  CB  . LEU D 1 81  ? -3.099  3.990   -23.096 1.00 12.47 ? 81  LEU D CB  1 
ATOM   7072 C  CG  . LEU D 1 81  ? -2.632  3.084   -24.268 1.00 12.34 ? 81  LEU D CG  1 
ATOM   7073 C  CD1 . LEU D 1 81  ? -2.143  3.943   -25.448 1.00 14.93 ? 81  LEU D CD1 1 
ATOM   7074 C  CD2 . LEU D 1 81  ? -1.492  2.288   -23.664 1.00 12.35 ? 81  LEU D CD2 1 
ATOM   7075 N  N   . GLN D 1 82  ? -3.362  5.185   -20.391 1.00 12.54 ? 82  GLN D N   1 
ATOM   7076 C  CA  . GLN D 1 82  ? -3.732  6.161   -19.304 1.00 11.41 ? 82  GLN D CA  1 
ATOM   7077 C  C   . GLN D 1 82  ? -4.687  7.229   -19.723 1.00 11.99 ? 82  GLN D C   1 
ATOM   7078 O  O   . GLN D 1 82  ? -5.346  7.814   -18.908 1.00 11.39 ? 82  GLN D O   1 
ATOM   7079 C  CB  . GLN D 1 82  ? -2.491  6.785   -18.697 1.00 12.40 ? 82  GLN D CB  1 
ATOM   7080 C  CG  . GLN D 1 82  ? -2.004  8.085   -19.313 1.00 15.91 ? 82  GLN D CG  1 
ATOM   7081 C  CD  . GLN D 1 82  ? -1.519  7.942   -20.735 1.00 16.13 ? 82  GLN D CD  1 
ATOM   7082 O  OE1 . GLN D 1 82  ? -1.294  6.827   -21.297 1.00 17.26 ? 82  GLN D OE1 1 
ATOM   7083 N  NE2 . GLN D 1 82  ? -1.372  9.084   -21.360 1.00 16.70 ? 82  GLN D NE2 1 
ATOM   7084 N  N   . SER D 1 83  ? -4.837  7.388   -21.027 1.00 9.81  ? 83  SER D N   1 
ATOM   7085 C  CA  . SER D 1 83  ? -5.807  8.325   -21.640 1.00 9.58  ? 83  SER D CA  1 
ATOM   7086 C  C   . SER D 1 83  ? -6.336  7.714   -22.922 1.00 9.76  ? 83  SER D C   1 
ATOM   7087 O  O   . SER D 1 83  ? -5.742  6.749   -23.420 1.00 9.65  ? 83  SER D O   1 
ATOM   7088 C  CB  . SER D 1 83  ? -5.082  9.590   -22.098 1.00 11.78 ? 83  SER D CB  1 
ATOM   7089 O  OG  . SER D 1 83  ? -4.463  10.236  -20.977 1.00 11.65 ? 83  SER D OG  1 
ATOM   7090 N  N   A ARG D 1 84  ? -7.419  8.225   -23.492 0.50 10.30 ? 84  ARG D N   1 
ATOM   7091 N  N   B ARG D 1 84  ? -7.426  8.242   -23.483 0.50 8.98  ? 84  ARG D N   1 
ATOM   7092 C  CA  A ARG D 1 84  ? -7.839  7.780   -24.820 0.50 10.99 ? 84  ARG D CA  1 
ATOM   7093 C  CA  B ARG D 1 84  ? -7.879  7.913   -24.848 0.50 8.84  ? 84  ARG D CA  1 
ATOM   7094 C  C   A ARG D 1 84  ? -6.972  8.416   -25.890 0.50 9.34  ? 84  ARG D C   1 
ATOM   7095 C  C   B ARG D 1 84  ? -6.841  8.434   -25.815 0.50 8.12  ? 84  ARG D C   1 
ATOM   7096 O  O   A ARG D 1 84  ? -6.812  9.647   -25.943 0.50 9.10  ? 84  ARG D O   1 
ATOM   7097 O  O   B ARG D 1 84  ? -6.413  9.613   -25.711 0.50 8.27  ? 84  ARG D O   1 
ATOM   7098 C  CB  A ARG D 1 84  ? -9.297  8.128   -25.106 0.50 11.88 ? 84  ARG D CB  1 
ATOM   7099 C  CB  B ARG D 1 84  ? -9.245  8.571   -25.160 0.50 7.79  ? 84  ARG D CB  1 
ATOM   7100 C  CG  A ARG D 1 84  ? -9.580  7.731   -26.574 0.50 15.33 ? 84  ARG D CG  1 
ATOM   7101 C  CG  B ARG D 1 84  ? -9.668  8.329   -26.616 0.50 8.55  ? 84  ARG D CG  1 
ATOM   7102 C  CD  A ARG D 1 84  ? -10.988 8.022   -27.033 0.50 18.45 ? 84  ARG D CD  1 
ATOM   7103 C  CD  B ARG D 1 84  ? -11.150 8.657   -26.845 0.50 9.28  ? 84  ARG D CD  1 
ATOM   7104 N  NE  A ARG D 1 84  ? -11.931 7.670   -25.999 0.50 20.63 ? 84  ARG D NE  1 
ATOM   7105 N  NE  B ARG D 1 84  ? -11.267 8.717   -28.306 0.50 9.47  ? 84  ARG D NE  1 
ATOM   7106 C  CZ  A ARG D 1 84  ? -13.257 7.703   -26.183 0.50 24.18 ? 84  ARG D CZ  1 
ATOM   7107 C  CZ  B ARG D 1 84  ? -12.422 8.594   -28.990 0.50 10.48 ? 84  ARG D CZ  1 
ATOM   7108 N  NH1 A ARG D 1 84  ? -13.745 8.046   -27.358 0.50 22.36 ? 84  ARG D NH1 1 
ATOM   7109 N  NH1 B ARG D 1 84  ? -13.582 8.552   -28.320 0.50 13.04 ? 84  ARG D NH1 1 
ATOM   7110 N  NH2 A ARG D 1 84  ? -14.082 7.409   -25.198 0.50 25.38 ? 84  ARG D NH2 1 
ATOM   7111 N  NH2 B ARG D 1 84  ? -12.463 8.647   -30.348 0.50 10.22 ? 84  ARG D NH2 1 
ATOM   7112 N  N   . TYR D 1 85  ? -6.458  7.570   -26.784 1.00 8.15  ? 85  TYR D N   1 
ATOM   7113 C  CA  . TYR D 1 85  ? -5.673  8.012   -27.925 1.00 7.31  ? 85  TYR D CA  1 
ATOM   7114 C  C   . TYR D 1 85  ? -6.472  7.791   -29.136 1.00 8.45  ? 85  TYR D C   1 
ATOM   7115 O  O   . TYR D 1 85  ? -6.955  6.674   -29.423 1.00 10.51 ? 85  TYR D O   1 
ATOM   7116 C  CB  . TYR D 1 85  ? -4.371  7.266   -27.889 1.00 6.55  ? 85  TYR D CB  1 
ATOM   7117 C  CG  . TYR D 1 85  ? -3.376  7.813   -26.881 1.00 6.14  ? 85  TYR D CG  1 
ATOM   7118 C  CD1 . TYR D 1 85  ? -2.361  8.693   -27.263 1.00 6.46  ? 85  TYR D CD1 1 
ATOM   7119 C  CD2 . TYR D 1 85  ? -3.348  7.330   -25.569 1.00 6.53  ? 85  TYR D CD2 1 
ATOM   7120 C  CE1 . TYR D 1 85  ? -1.438  9.138   -26.339 1.00 6.82  ? 85  TYR D CE1 1 
ATOM   7121 C  CE2 . TYR D 1 85  ? -2.425  7.778   -24.657 1.00 7.11  ? 85  TYR D CE2 1 
ATOM   7122 C  CZ  . TYR D 1 85  ? -1.517  8.753   -25.045 1.00 7.49  ? 85  TYR D CZ  1 
ATOM   7123 O  OH  . TYR D 1 85  ? -0.561  9.181   -24.154 1.00 9.15  ? 85  TYR D OH  1 
ATOM   7124 N  N   . SER D 1 86  ? -6.625  8.821   -29.941 1.00 6.76  ? 86  SER D N   1 
ATOM   7125 C  CA  . SER D 1 86  ? -7.410  8.760   -31.145 1.00 7.27  ? 86  SER D CA  1 
ATOM   7126 C  C   . SER D 1 86  ? -6.487  8.687   -32.362 1.00 5.99  ? 86  SER D C   1 
ATOM   7127 O  O   . SER D 1 86  ? -5.407  9.314   -32.438 1.00 6.36  ? 86  SER D O   1 
ATOM   7128 C  CB  . SER D 1 86  ? -8.215  10.052  -31.303 1.00 8.47  ? 86  SER D CB  1 
ATOM   7129 O  OG  . SER D 1 86  ? -9.203  10.068  -30.239 1.00 10.38 ? 86  SER D OG  1 
ATOM   7130 N  N   . ALA D 1 87  ? -6.917  7.877   -33.333 1.00 6.58  ? 87  ALA D N   1 
ATOM   7131 C  CA  . ALA D 1 87  ? -6.057  7.729   -34.527 1.00 7.01  ? 87  ALA D CA  1 
ATOM   7132 C  C   . ALA D 1 87  ? -5.943  8.984   -35.322 1.00 7.72  ? 87  ALA D C   1 
ATOM   7133 O  O   . ALA D 1 87  ? -6.898  9.825   -35.370 1.00 8.53  ? 87  ALA D O   1 
ATOM   7134 C  CB  . ALA D 1 87  ? -6.610  6.645   -35.431 1.00 7.38  ? 87  ALA D CB  1 
ATOM   7135 N  N   . THR D 1 88  ? -4.790  9.127   -35.959 1.00 6.75  ? 88  THR D N   1 
ATOM   7136 C  CA  . THR D 1 88  ? -4.543  10.244  -36.917 1.00 7.87  ? 88  THR D CA  1 
ATOM   7137 C  C   . THR D 1 88  ? -4.076  9.788   -38.279 1.00 6.42  ? 88  THR D C   1 
ATOM   7138 O  O   . THR D 1 88  ? -4.529  10.318  -39.307 1.00 6.43  ? 88  THR D O   1 
ATOM   7139 C  CB  . THR D 1 88  ? -3.700  11.347  -36.301 1.00 8.98  ? 88  THR D CB  1 
ATOM   7140 O  OG1 . THR D 1 88  ? -3.637  12.438  -37.239 1.00 12.93 ? 88  THR D OG1 1 
ATOM   7141 C  CG2 . THR D 1 88  ? -2.318  10.893  -35.917 1.00 10.02 ? 88  THR D CG2 1 
ATOM   7142 N  N   . GLN D 1 89  ? -3.145  8.799   -38.322 1.00 5.64  ? 89  GLN D N   1 
ATOM   7143 C  CA  . GLN D 1 89  ? -2.682  8.331   -39.639 1.00 5.69  ? 89  GLN D CA  1 
ATOM   7144 C  C   . GLN D 1 89  ? -1.952  7.024   -39.460 1.00 4.87  ? 89  GLN D C   1 
ATOM   7145 O  O   . GLN D 1 89  ? -1.551  6.721   -38.331 1.00 5.13  ? 89  GLN D O   1 
ATOM   7146 C  CB  . GLN D 1 89  ? -1.744  9.404   -40.292 1.00 6.39  ? 89  GLN D CB  1 
ATOM   7147 C  CG  . GLN D 1 89  ? -0.594  9.781   -39.438 1.00 7.54  ? 89  GLN D CG  1 
ATOM   7148 C  CD  . GLN D 1 89  ? 0.689   9.249   -39.960 1.00 8.97  ? 89  GLN D CD  1 
ATOM   7149 O  OE1 . GLN D 1 89  ? 0.831   8.114   -40.155 1.00 9.72  ? 89  GLN D OE1 1 
ATOM   7150 N  NE2 . GLN D 1 89  ? 1.622   10.093  -40.245 1.00 12.28 ? 89  GLN D NE2 1 
ATOM   7151 N  N   . LEU D 1 90  ? -1.773  6.308   -40.547 1.00 4.35  ? 90  LEU D N   1 
ATOM   7152 C  CA  . LEU D 1 90  ? -0.796  5.223   -40.501 1.00 4.42  ? 90  LEU D CA  1 
ATOM   7153 C  C   . LEU D 1 90  ? 0.166   5.402   -41.696 1.00 4.02  ? 90  LEU D C   1 
ATOM   7154 O  O   . LEU D 1 90  ? -0.103  6.058   -42.666 1.00 4.76  ? 90  LEU D O   1 
ATOM   7155 C  CB  . LEU D 1 90  ? -1.473  3.845   -40.496 1.00 4.74  ? 90  LEU D CB  1 
ATOM   7156 C  CG  . LEU D 1 90  ? -2.392  3.500   -41.634 1.00 4.46  ? 90  LEU D CG  1 
ATOM   7157 C  CD1 . LEU D 1 90  ? -1.672  3.130   -42.924 1.00 5.27  ? 90  LEU D CD1 1 
ATOM   7158 C  CD2 . LEU D 1 90  ? -3.325  2.307   -41.187 1.00 6.25  ? 90  LEU D CD2 1 
ATOM   7159 N  N   . HIS D 1 91  ? 1.342   4.754   -41.594 1.00 3.91  ? 91  HIS D N   1 
ATOM   7160 C  CA  . HIS D 1 91  ? 2.356   4.822   -42.600 1.00 3.87  ? 91  HIS D CA  1 
ATOM   7161 C  C   . HIS D 1 91  ? 3.278   3.635   -42.403 1.00 3.96  ? 91  HIS D C   1 
ATOM   7162 O  O   . HIS D 1 91  ? 3.162   2.904   -41.408 1.00 3.92  ? 91  HIS D O   1 
ATOM   7163 C  CB  . HIS D 1 91  ? 3.145   6.180   -42.513 1.00 4.07  ? 91  HIS D CB  1 
ATOM   7164 C  CG  . HIS D 1 91  ? 3.837   6.348   -41.192 1.00 3.53  ? 91  HIS D CG  1 
ATOM   7165 N  ND1 . HIS D 1 91  ? 3.247   6.916   -40.081 1.00 4.18  ? 91  HIS D ND1 1 
ATOM   7166 C  CD2 . HIS D 1 91  ? 5.115   5.903   -40.793 1.00 3.85  ? 91  HIS D CD2 1 
ATOM   7167 C  CE1 . HIS D 1 91  ? 4.129   6.813   -39.071 1.00 3.64  ? 91  HIS D CE1 1 
ATOM   7168 N  NE2 . HIS D 1 91  ? 5.233   6.133   -39.485 1.00 3.67  ? 91  HIS D NE2 1 
ATOM   7169 N  N   . LEU D 1 92  ? 4.232   3.514   -43.328 1.00 5.32  ? 92  LEU D N   1 
ATOM   7170 C  CA  . LEU D 1 92  ? 5.163   2.405   -43.285 1.00 5.26  ? 92  LEU D CA  1 
ATOM   7171 C  C   . LEU D 1 92  ? 6.594   2.883   -43.447 1.00 4.73  ? 92  LEU D C   1 
ATOM   7172 O  O   . LEU D 1 92  ? 6.879   4.004   -43.816 1.00 5.49  ? 92  LEU D O   1 
ATOM   7173 C  CB  . LEU D 1 92  ? 4.871   1.397   -44.369 1.00 7.06  ? 92  LEU D CB  1 
ATOM   7174 C  CG  . LEU D 1 92  ? 3.504   0.657   -44.236 1.00 8.71  ? 92  LEU D CG  1 
ATOM   7175 C  CD1 . LEU D 1 92  ? 2.534   1.343   -45.117 1.00 11.42 ? 92  LEU D CD1 1 
ATOM   7176 C  CD2 . LEU D 1 92  ? 3.633   -0.792  -44.558 1.00 10.36 ? 92  LEU D CD2 1 
ATOM   7177 N  N   . HIS D 1 93  ? 7.471   1.939   -43.070 1.00 4.72  ? 93  HIS D N   1 
ATOM   7178 C  CA  . HIS D 1 93  ? 8.943   2.096   -43.312 1.00 4.52  ? 93  HIS D CA  1 
ATOM   7179 C  C   . HIS D 1 93  ? 9.459   0.865   -43.947 1.00 4.41  ? 93  HIS D C   1 
ATOM   7180 O  O   . HIS D 1 93  ? 8.972   -0.244  -43.637 1.00 4.52  ? 93  HIS D O   1 
ATOM   7181 C  CB  . HIS D 1 93  ? 9.643   2.277   -41.946 1.00 4.29  ? 93  HIS D CB  1 
ATOM   7182 C  CG  . HIS D 1 93  ? 9.159   3.398   -41.151 1.00 4.62  ? 93  HIS D CG  1 
ATOM   7183 N  ND1 . HIS D 1 93  ? 9.770   4.648   -41.262 1.00 4.98  ? 93  HIS D ND1 1 
ATOM   7184 C  CD2 . HIS D 1 93  ? 8.073   3.513   -40.344 1.00 4.03  ? 93  HIS D CD2 1 
ATOM   7185 C  CE1 . HIS D 1 93  ? 9.114   5.523   -40.449 1.00 4.38  ? 93  HIS D CE1 1 
ATOM   7186 N  NE2 . HIS D 1 93  ? 8.097   4.869   -39.841 1.00 3.55  ? 93  HIS D NE2 1 
ATOM   7187 N  N   . TRP D 1 94  ? 10.421  1.033   -44.885 1.00 4.08  ? 94  TRP D N   1 
ATOM   7188 C  CA  . TRP D 1 94  ? 10.940  -0.161  -45.687 1.00 4.17  ? 94  TRP D CA  1 
ATOM   7189 C  C   . TRP D 1 94  ? 12.331  0.088   -46.122 1.00 4.38  ? 94  TRP D C   1 
ATOM   7190 O  O   . TRP D 1 94  ? 12.935  1.146   -45.892 1.00 4.67  ? 94  TRP D O   1 
ATOM   7191 C  CB  . TRP D 1 94  ? 9.963   -0.478  -46.823 1.00 4.69  ? 94  TRP D CB  1 
ATOM   7192 C  CG  . TRP D 1 94  ? 9.852   0.729   -47.785 1.00 4.46  ? 94  TRP D CG  1 
ATOM   7193 C  CD1 . TRP D 1 94  ? 10.682  1.077   -48.823 1.00 5.37  ? 94  TRP D CD1 1 
ATOM   7194 C  CD2 . TRP D 1 94  ? 8.835   1.763   -47.690 1.00 4.90  ? 94  TRP D CD2 1 
ATOM   7195 N  NE1 . TRP D 1 94  ? 10.240  2.225   -49.445 1.00 5.91  ? 94  TRP D NE1 1 
ATOM   7196 C  CE2 . TRP D 1 94  ? 9.119   2.706   -48.740 1.00 5.45  ? 94  TRP D CE2 1 
ATOM   7197 C  CE3 . TRP D 1 94  ? 7.736   2.003   -46.844 1.00 5.60  ? 94  TRP D CE3 1 
ATOM   7198 C  CZ2 . TRP D 1 94  ? 8.288   3.804   -48.991 1.00 6.47  ? 94  TRP D CZ2 1 
ATOM   7199 C  CZ3 . TRP D 1 94  ? 6.965   3.174   -47.098 1.00 5.37  ? 94  TRP D CZ3 1 
ATOM   7200 C  CH2 . TRP D 1 94  ? 7.222   4.033   -48.132 1.00 6.12  ? 94  TRP D CH2 1 
ATOM   7201 N  N   . GLY D 1 95  ? 12.880  -0.946  -46.745 1.00 4.86  ? 95  GLY D N   1 
ATOM   7202 C  CA  . GLY D 1 95  ? 14.322  -0.955  -47.183 1.00 5.87  ? 95  GLY D CA  1 
ATOM   7203 C  C   . GLY D 1 95  ? 14.348  -0.703  -48.690 1.00 6.75  ? 95  GLY D C   1 
ATOM   7204 O  O   . GLY D 1 95  ? 13.852  0.333   -49.204 1.00 7.17  ? 95  GLY D O   1 
ATOM   7205 N  N   . ASN D 1 96  ? 14.909  -1.662  -49.450 1.00 7.92  ? 96  ASN D N   1 
ATOM   7206 C  CA  . ASN D 1 96  ? 14.985  -1.425  -50.889 1.00 10.03 ? 96  ASN D CA  1 
ATOM   7207 C  C   . ASN D 1 96  ? 15.145  -2.806  -51.493 1.00 10.62 ? 96  ASN D C   1 
ATOM   7208 O  O   . ASN D 1 96  ? 15.325  -3.756  -50.763 1.00 10.65 ? 96  ASN D O   1 
ATOM   7209 C  CB  . ASN D 1 96  ? 16.225  -0.518  -51.219 1.00 12.49 ? 96  ASN D CB  1 
ATOM   7210 C  CG  . ASN D 1 96  ? 17.549  -1.211  -51.003 1.00 15.18 ? 96  ASN D CG  1 
ATOM   7211 O  OD1 . ASN D 1 96  ? 17.966  -1.970  -51.898 1.00 21.30 ? 96  ASN D OD1 1 
ATOM   7212 N  ND2 . ASN D 1 96  ? 18.209  -1.005  -49.909 1.00 13.10 ? 96  ASN D ND2 1 
ATOM   7213 N  N   . PRO D 1 97  ? 15.041  -2.893  -52.849 1.00 13.99 ? 97  PRO D N   1 
ATOM   7214 C  CA  . PRO D 1 97  ? 15.001  -4.228  -53.477 1.00 15.47 ? 97  PRO D CA  1 
ATOM   7215 C  C   . PRO D 1 97  ? 16.243  -5.097  -53.188 1.00 15.88 ? 97  PRO D C   1 
ATOM   7216 O  O   . PRO D 1 97  ? 16.093  -6.332  -52.978 1.00 21.38 ? 97  PRO D O   1 
ATOM   7217 C  CB  . PRO D 1 97  ? 14.843  -3.855  -54.951 1.00 17.53 ? 97  PRO D CB  1 
ATOM   7218 C  CG  . PRO D 1 97  ? 14.151  -2.532  -54.976 1.00 18.43 ? 97  PRO D CG  1 
ATOM   7219 C  CD  . PRO D 1 97  ? 14.821  -1.839  -53.820 1.00 13.56 ? 97  PRO D CD  1 
ATOM   7220 N  N   . ASN D 1 98  ? 17.385  -4.432  -53.000 1.00 16.18 ? 98  ASN D N   1 
ATOM   7221 C  CA  . ASN D 1 98  ? 18.635  -5.099  -52.695 1.00 19.81 ? 98  ASN D CA  1 
ATOM   7222 C  C   . ASN D 1 98  ? 18.865  -5.440  -51.214 1.00 20.37 ? 98  ASN D C   1 
ATOM   7223 O  O   . ASN D 1 98  ? 19.806  -6.159  -50.841 1.00 23.82 ? 98  ASN D O   1 
ATOM   7224 C  CB  . ASN D 1 98  ? 19.788  -4.271  -53.282 1.00 23.02 ? 98  ASN D CB  1 
ATOM   7225 C  CG  . ASN D 1 98  ? 19.701  -4.176  -54.840 1.00 26.71 ? 98  ASN D CG  1 
ATOM   7226 O  OD1 . ASN D 1 98  ? 19.281  -5.128  -55.496 1.00 37.31 ? 98  ASN D OD1 1 
ATOM   7227 N  ND2 . ASN D 1 98  ? 20.056  -3.037  -55.403 1.00 32.78 ? 98  ASN D ND2 1 
ATOM   7228 N  N   . ASP D 1 99  ? 18.046  -4.853  -50.341 1.00 15.51 ? 99  ASP D N   1 
ATOM   7229 C  CA  . ASP D 1 99  ? 18.170  -5.090  -48.913 1.00 14.64 ? 99  ASP D CA  1 
ATOM   7230 C  C   . ASP D 1 99  ? 16.738  -4.888  -48.341 1.00 13.06 ? 99  ASP D C   1 
ATOM   7231 O  O   . ASP D 1 99  ? 16.401  -3.786  -47.853 1.00 11.26 ? 99  ASP D O   1 
ATOM   7232 C  CB  . ASP D 1 99  ? 19.149  -4.086  -48.310 1.00 16.42 ? 99  ASP D CB  1 
ATOM   7233 C  CG  . ASP D 1 99  ? 19.312  -4.254  -46.782 1.00 21.46 ? 99  ASP D CG  1 
ATOM   7234 O  OD1 . ASP D 1 99  ? 19.028  -5.384  -46.304 1.00 22.40 ? 99  ASP D OD1 1 
ATOM   7235 O  OD2 . ASP D 1 99  ? 19.680  -3.244  -46.109 1.00 28.70 ? 99  ASP D OD2 1 
ATOM   7236 N  N   . PRO D 1 100 ? 15.882  -5.867  -48.442 1.00 12.21 ? 100 PRO D N   1 
ATOM   7237 C  CA  . PRO D 1 100 ? 14.455  -5.782  -48.049 1.00 12.21 ? 100 PRO D CA  1 
ATOM   7238 C  C   . PRO D 1 100 ? 14.384  -6.022  -46.531 1.00 10.77 ? 100 PRO D C   1 
ATOM   7239 O  O   . PRO D 1 100 ? 13.780  -6.939  -46.027 1.00 11.44 ? 100 PRO D O   1 
ATOM   7240 C  CB  . PRO D 1 100 ? 13.793  -6.879  -48.866 1.00 13.33 ? 100 PRO D CB  1 
ATOM   7241 C  CG  . PRO D 1 100 ? 14.936  -7.903  -49.075 1.00 13.41 ? 100 PRO D CG  1 
ATOM   7242 C  CD  . PRO D 1 100 ? 16.171  -7.088  -49.269 1.00 14.45 ? 100 PRO D CD  1 
ATOM   7243 N  N   . HIS D 1 101 ? 15.100  -5.156  -45.790 1.00 10.54 ? 101 HIS D N   1 
ATOM   7244 C  CA  . HIS D 1 101 ? 15.213  -5.274  -44.340 1.00 10.74 ? 101 HIS D CA  1 
ATOM   7245 C  C   . HIS D 1 101 ? 15.137  -3.944  -43.678 1.00 10.58 ? 101 HIS D C   1 
ATOM   7246 O  O   . HIS D 1 101 ? 16.107  -3.464  -43.017 1.00 13.47 ? 101 HIS D O   1 
ATOM   7247 C  CB  . HIS D 1 101 ? 16.507  -6.014  -43.923 1.00 12.91 ? 101 HIS D CB  1 
ATOM   7248 C  CG  . HIS D 1 101 ? 16.609  -7.386  -44.576 1.00 16.16 ? 101 HIS D CG  1 
ATOM   7249 N  ND1 . HIS D 1 101 ? 15.954  -8.509  -44.110 1.00 20.69 ? 101 HIS D ND1 1 
ATOM   7250 C  CD2 . HIS D 1 101 ? 17.253  -7.783  -45.741 1.00 18.43 ? 101 HIS D CD2 1 
ATOM   7251 C  CE1 . HIS D 1 101 ? 16.207  -9.562  -44.936 1.00 23.13 ? 101 HIS D CE1 1 
ATOM   7252 N  NE2 . HIS D 1 101 ? 16.992  -9.127  -45.930 1.00 21.65 ? 101 HIS D NE2 1 
ATOM   7253 N  N   . GLY D 1 102 ? 13.977  -3.309  -43.790 1.00 7.73  ? 102 GLY D N   1 
ATOM   7254 C  CA  . GLY D 1 102 ? 13.851  -1.911  -43.436 1.00 6.69  ? 102 GLY D CA  1 
ATOM   7255 C  C   . GLY D 1 102 ? 12.886  -1.598  -42.314 1.00 5.42  ? 102 GLY D C   1 
ATOM   7256 O  O   . GLY D 1 102 ? 12.370  -0.484  -42.211 1.00 7.45  ? 102 GLY D O   1 
ATOM   7257 N  N   . SER D 1 103 ? 12.633  -2.575  -41.430 1.00 5.35  ? 103 SER D N   1 
ATOM   7258 C  CA  . SER D 1 103 ? 11.896  -2.229  -40.188 1.00 5.43  ? 103 SER D CA  1 
ATOM   7259 C  C   . SER D 1 103 ? 12.680  -1.223  -39.382 1.00 5.98  ? 103 SER D C   1 
ATOM   7260 O  O   . SER D 1 103 ? 13.919  -1.179  -39.491 1.00 7.15  ? 103 SER D O   1 
ATOM   7261 C  CB  . SER D 1 103 ? 11.543  -3.467  -39.365 1.00 5.42  ? 103 SER D CB  1 
ATOM   7262 O  OG  . SER D 1 103 ? 12.747  -4.015  -38.776 1.00 5.00  ? 103 SER D OG  1 
ATOM   7263 N  N   . GLU D 1 104 ? 11.986  -0.434  -38.570 1.00 5.58  ? 104 GLU D N   1 
ATOM   7264 C  CA  . GLU D 1 104 ? 12.715  0.390   -37.603 1.00 5.34  ? 104 GLU D CA  1 
ATOM   7265 C  C   . GLU D 1 104 ? 13.128  -0.277  -36.331 1.00 5.11  ? 104 GLU D C   1 
ATOM   7266 O  O   . GLU D 1 104 ? 14.323  -0.322  -36.000 1.00 6.15  ? 104 GLU D O   1 
ATOM   7267 C  CB  . GLU D 1 104 ? 11.821  1.639   -37.313 1.00 5.66  ? 104 GLU D CB  1 
ATOM   7268 C  CG  . GLU D 1 104 ? 11.442  2.372   -38.597 1.00 6.28  ? 104 GLU D CG  1 
ATOM   7269 C  CD  . GLU D 1 104 ? 11.372  3.837   -38.346 1.00 7.14  ? 104 GLU D CD  1 
ATOM   7270 O  OE1 . GLU D 1 104 ? 10.384  4.321   -37.741 1.00 7.56  ? 104 GLU D OE1 1 
ATOM   7271 O  OE2 . GLU D 1 104 ? 12.311  4.580   -38.708 1.00 7.27  ? 104 GLU D OE2 1 
ATOM   7272 N  N   . HIS D 1 105 ? 12.190  -0.874  -35.641 1.00 5.08  ? 105 HIS D N   1 
ATOM   7273 C  CA  . HIS D 1 105 ? 12.544  -1.769  -34.527 1.00 5.31  ? 105 HIS D CA  1 
ATOM   7274 C  C   . HIS D 1 105 ? 13.138  -3.003  -35.082 1.00 5.50  ? 105 HIS D C   1 
ATOM   7275 O  O   . HIS D 1 105 ? 12.827  -3.507  -36.125 1.00 6.16  ? 105 HIS D O   1 
ATOM   7276 C  CB  . HIS D 1 105 ? 11.273  -2.037  -33.705 1.00 5.26  ? 105 HIS D CB  1 
ATOM   7277 C  CG  . HIS D 1 105 ? 10.782  -0.814  -33.012 1.00 5.58  ? 105 HIS D CG  1 
ATOM   7278 N  ND1 . HIS D 1 105 ? 9.869   0.029   -33.586 1.00 6.52  ? 105 HIS D ND1 1 
ATOM   7279 C  CD2 . HIS D 1 105 ? 11.161  -0.247  -31.828 1.00 5.87  ? 105 HIS D CD2 1 
ATOM   7280 C  CE1 . HIS D 1 105 ? 9.663   1.087   -32.762 1.00 7.20  ? 105 HIS D CE1 1 
ATOM   7281 N  NE2 . HIS D 1 105 ? 10.459  0.949   -31.705 1.00 7.38  ? 105 HIS D NE2 1 
ATOM   7282 N  N   . THR D 1 106 ? 14.082  -3.495  -34.303 1.00 5.83  ? 106 THR D N   1 
ATOM   7283 C  CA  . THR D 1 106 ? 14.686  -4.813  -34.563 1.00 6.24  ? 106 THR D CA  1 
ATOM   7284 C  C   . THR D 1 106 ? 14.411  -5.733  -33.353 1.00 6.65  ? 106 THR D C   1 
ATOM   7285 O  O   . THR D 1 106 ? 14.135  -5.239  -32.238 1.00 6.11  ? 106 THR D O   1 
ATOM   7286 C  CB  . THR D 1 106 ? 16.166  -4.695  -34.872 1.00 6.90  ? 106 THR D CB  1 
ATOM   7287 O  OG1 . THR D 1 106 ? 16.832  -4.123  -33.735 1.00 8.02  ? 106 THR D OG1 1 
ATOM   7288 C  CG2 . THR D 1 106 ? 16.440  -3.760  -36.032 1.00 7.56  ? 106 THR D CG2 1 
ATOM   7289 N  N   . VAL D 1 107 ? 14.518  -7.066  -33.592 1.00 6.47  ? 107 VAL D N   1 
ATOM   7290 C  CA  . VAL D 1 107 ? 14.276  -8.026  -32.492 1.00 8.26  ? 107 VAL D CA  1 
ATOM   7291 C  C   . VAL D 1 107 ? 15.493  -8.906  -32.489 1.00 7.96  ? 107 VAL D C   1 
ATOM   7292 O  O   . VAL D 1 107 ? 15.856  -9.486  -33.513 1.00 9.36  ? 107 VAL D O   1 
ATOM   7293 C  CB  . VAL D 1 107 ? 12.964  -8.824  -32.715 1.00 8.19  ? 107 VAL D CB  1 
ATOM   7294 C  CG1 . VAL D 1 107 ? 12.906  -9.858  -31.596 1.00 10.66 ? 107 VAL D CG1 1 
ATOM   7295 C  CG2 . VAL D 1 107 ? 11.728  -7.876  -32.670 1.00 8.66  ? 107 VAL D CG2 1 
ATOM   7296 N  N   . SER D 1 108 ? 16.109  -8.893  -31.337 1.00 8.90  ? 108 SER D N   1 
ATOM   7297 C  CA  . SER D 1 108 ? 17.406  -9.674  -31.184 1.00 10.00 ? 108 SER D CA  1 
ATOM   7298 C  C   . SER D 1 108 ? 18.338  -9.387  -32.301 1.00 9.89  ? 108 SER D C   1 
ATOM   7299 O  O   . SER D 1 108 ? 18.974  -10.304 -32.871 1.00 11.94 ? 108 SER D O   1 
ATOM   7300 C  CB  . SER D 1 108 ? 17.084  -11.169 -31.056 1.00 10.91 ? 108 SER D CB  1 
ATOM   7301 O  OG  . SER D 1 108 ? 16.330  -11.313 -29.849 1.00 14.33 ? 108 SER D OG  1 
ATOM   7302 N  N   . GLY D 1 109 ? 18.452  -8.114  -32.623 1.00 8.79  ? 109 GLY D N   1 
ATOM   7303 C  CA  . GLY D 1 109 ? 19.389  -7.690  -33.664 1.00 10.83 ? 109 GLY D CA  1 
ATOM   7304 C  C   . GLY D 1 109 ? 18.987  -7.823  -35.122 1.00 12.02 ? 109 GLY D C   1 
ATOM   7305 O  O   . GLY D 1 109 ? 19.773  -7.455  -36.039 1.00 15.27 ? 109 GLY D O   1 
ATOM   7306 N  N   A GLN D 1 110 ? 17.795  -8.290  -35.365 0.50 10.49 ? 110 GLN D N   1 
ATOM   7307 N  N   B GLN D 1 110 ? 17.781  -8.314  -35.346 0.50 11.17 ? 110 GLN D N   1 
ATOM   7308 C  CA  A GLN D 1 110 ? 17.430  -8.545  -36.725 0.50 11.43 ? 110 GLN D CA  1 
ATOM   7309 C  CA  B GLN D 1 110 ? 17.304  -8.722  -36.668 0.50 12.38 ? 110 GLN D CA  1 
ATOM   7310 C  C   A GLN D 1 110 ? 16.311  -7.611  -37.117 0.50 9.08  ? 110 GLN D C   1 
ATOM   7311 C  C   B GLN D 1 110 ? 16.275  -7.664  -37.129 0.50 9.61  ? 110 GLN D C   1 
ATOM   7312 O  O   A GLN D 1 110 ? 15.314  -7.458  -36.406 0.50 8.10  ? 110 GLN D O   1 
ATOM   7313 O  O   B GLN D 1 110 ? 15.290  -7.444  -36.420 0.50 8.41  ? 110 GLN D O   1 
ATOM   7314 C  CB  A GLN D 1 110 ? 16.940  -9.962  -36.914 0.50 11.91 ? 110 GLN D CB  1 
ATOM   7315 C  CB  B GLN D 1 110 ? 16.592  -10.081 -36.595 0.50 14.60 ? 110 GLN D CB  1 
ATOM   7316 C  CG  A GLN D 1 110 ? 17.787  -11.015 -36.214 0.50 14.40 ? 110 GLN D CG  1 
ATOM   7317 C  CG  B GLN D 1 110 ? 17.443  -11.312 -36.179 0.50 18.64 ? 110 GLN D CG  1 
ATOM   7318 C  CD  A GLN D 1 110 ? 19.213  -10.894 -36.613 0.50 14.64 ? 110 GLN D CD  1 
ATOM   7319 C  CD  B GLN D 1 110 ? 18.059  -12.020 -37.353 0.50 21.52 ? 110 GLN D CD  1 
ATOM   7320 O  OE1 A GLN D 1 110 ? 19.508  -10.984 -37.788 0.50 18.01 ? 110 GLN D OE1 1 
ATOM   7321 O  OE1 B GLN D 1 110 ? 17.631  -13.090 -37.728 0.50 27.11 ? 110 GLN D OE1 1 
ATOM   7322 N  NE2 A GLN D 1 110 ? 20.114  -10.704 -35.644 0.50 15.10 ? 110 GLN D NE2 1 
ATOM   7323 N  NE2 B GLN D 1 110 ? 19.018  -11.374 -37.996 0.50 22.06 ? 110 GLN D NE2 1 
ATOM   7324 N  N   . HIS D 1 111 ? 16.485  -7.021  -38.291 1.00 10.16 ? 111 HIS D N   1 
ATOM   7325 C  CA  . HIS D 1 111 ? 15.400  -6.287  -38.943 1.00 9.57  ? 111 HIS D CA  1 
ATOM   7326 C  C   . HIS D 1 111 ? 14.397  -7.216  -39.496 1.00 10.17 ? 111 HIS D C   1 
ATOM   7327 O  O   . HIS D 1 111 ? 14.681  -8.383  -39.878 1.00 11.91 ? 111 HIS D O   1 
ATOM   7328 C  CB  . HIS D 1 111 ? 15.874  -5.442  -40.151 1.00 10.47 ? 111 HIS D CB  1 
ATOM   7329 C  CG  . HIS D 1 111 ? 16.625  -4.210  -39.784 1.00 9.76  ? 111 HIS D CG  1 
ATOM   7330 N  ND1 . HIS D 1 111 ? 16.018  -3.007  -39.603 1.00 12.02 ? 111 HIS D ND1 1 
ATOM   7331 C  CD2 . HIS D 1 111 ? 17.981  -4.004  -39.581 1.00 12.10 ? 111 HIS D CD2 1 
ATOM   7332 C  CE1 . HIS D 1 111 ? 16.958  -2.069  -39.305 1.00 12.24 ? 111 HIS D CE1 1 
ATOM   7333 N  NE2 . HIS D 1 111 ? 18.161  -2.684  -39.256 1.00 14.49 ? 111 HIS D NE2 1 
ATOM   7334 N  N   . PHE D 1 112 ? 13.180  -6.726  -39.578 1.00 7.35  ? 112 PHE D N   1 
ATOM   7335 C  CA  . PHE D 1 112 ? 12.162  -7.321  -40.349 1.00 7.04  ? 112 PHE D CA  1 
ATOM   7336 C  C   . PHE D 1 112 ? 12.110  -6.583  -41.717 1.00 6.18  ? 112 PHE D C   1 
ATOM   7337 O  O   . PHE D 1 112 ? 12.830  -5.589  -41.889 1.00 6.67  ? 112 PHE D O   1 
ATOM   7338 C  CB  . PHE D 1 112 ? 10.834  -7.233  -39.622 1.00 8.45  ? 112 PHE D CB  1 
ATOM   7339 C  CG  . PHE D 1 112 ? 10.736  -8.208  -38.501 1.00 8.96  ? 112 PHE D CG  1 
ATOM   7340 C  CD1 . PHE D 1 112 ? 10.008  -9.383  -38.627 1.00 12.83 ? 112 PHE D CD1 1 
ATOM   7341 C  CD2 . PHE D 1 112 ? 11.445  -7.975  -37.344 1.00 12.20 ? 112 PHE D CD2 1 
ATOM   7342 C  CE1 . PHE D 1 112 ? 9.963   -10.292 -37.595 1.00 14.54 ? 112 PHE D CE1 1 
ATOM   7343 C  CE2 . PHE D 1 112 ? 11.411  -8.877  -36.308 1.00 16.05 ? 112 PHE D CE2 1 
ATOM   7344 C  CZ  . PHE D 1 112 ? 10.669  -10.038 -36.432 1.00 13.51 ? 112 PHE D CZ  1 
ATOM   7345 N  N   . ALA D 1 113 ? 11.323  -7.100  -42.640 1.00 5.30  ? 113 ALA D N   1 
ATOM   7346 C  CA  . ALA D 1 113 ? 11.311  -6.513  -43.943 1.00 6.17  ? 113 ALA D CA  1 
ATOM   7347 C  C   . ALA D 1 113 ? 10.825  -5.036  -43.926 1.00 5.69  ? 113 ALA D C   1 
ATOM   7348 O  O   . ALA D 1 113 ? 11.317  -4.214  -44.708 1.00 6.52  ? 113 ALA D O   1 
ATOM   7349 C  CB  . ALA D 1 113 ? 10.469  -7.349  -44.952 1.00 7.47  ? 113 ALA D CB  1 
ATOM   7350 N  N   . ALA D 1 114 ? 9.737   -4.804  -43.201 1.00 4.75  ? 114 ALA D N   1 
ATOM   7351 C  CA  . ALA D 1 114 ? 9.118   -3.451  -43.180 1.00 4.51  ? 114 ALA D CA  1 
ATOM   7352 C  C   . ALA D 1 114 ? 8.433   -3.343  -41.835 1.00 4.42  ? 114 ALA D C   1 
ATOM   7353 O  O   . ALA D 1 114 ? 8.437   -4.234  -40.977 1.00 4.60  ? 114 ALA D O   1 
ATOM   7354 C  CB  . ALA D 1 114 ? 8.207   -3.243  -44.363 1.00 5.21  ? 114 ALA D CB  1 
ATOM   7355 N  N   . GLU D 1 115 ? 7.815   -2.157  -41.619 1.00 4.56  ? 115 GLU D N   1 
ATOM   7356 C  CA  . GLU D 1 115 ? 7.093   -1.935  -40.343 1.00 4.72  ? 115 GLU D CA  1 
ATOM   7357 C  C   . GLU D 1 115 ? 5.961   -0.956  -40.638 1.00 4.89  ? 115 GLU D C   1 
ATOM   7358 O  O   . GLU D 1 115 ? 6.129   0.016   -41.385 1.00 6.13  ? 115 GLU D O   1 
ATOM   7359 C  CB  . GLU D 1 115 ? 8.078   -1.332  -39.323 1.00 5.23  ? 115 GLU D CB  1 
ATOM   7360 C  CG  . GLU D 1 115 ? 7.514   -1.168  -37.914 1.00 5.97  ? 115 GLU D CG  1 
ATOM   7361 C  CD  . GLU D 1 115 ? 8.611   -0.952  -36.912 1.00 6.05  ? 115 GLU D CD  1 
ATOM   7362 O  OE1 . GLU D 1 115 ? 9.787   -1.386  -37.124 1.00 6.98  ? 115 GLU D OE1 1 
ATOM   7363 O  OE2 . GLU D 1 115 ? 8.343   -0.264  -35.873 1.00 6.78  ? 115 GLU D OE2 1 
ATOM   7364 N  N   . LEU D 1 116 ? 4.806   -1.222  -40.051 1.00 4.21  ? 116 LEU D N   1 
ATOM   7365 C  CA  . LEU D 1 116 ? 3.601   -0.354  -40.078 1.00 4.15  ? 116 LEU D CA  1 
ATOM   7366 C  C   . LEU D 1 116 ? 3.451   0.328   -38.797 1.00 4.35  ? 116 LEU D C   1 
ATOM   7367 O  O   . LEU D 1 116 ? 3.568   -0.274  -37.729 1.00 5.07  ? 116 LEU D O   1 
ATOM   7368 C  CB  . LEU D 1 116 ? 2.342   -1.255  -40.272 1.00 4.64  ? 116 LEU D CB  1 
ATOM   7369 C  CG  . LEU D 1 116 ? 1.000   -0.429  -40.181 1.00 5.33  ? 116 LEU D CG  1 
ATOM   7370 C  CD1 . LEU D 1 116 ? 0.810   0.405   -41.379 1.00 6.51  ? 116 LEU D CD1 1 
ATOM   7371 C  CD2 . LEU D 1 116 ? -0.139  -1.428  -39.988 1.00 7.05  ? 116 LEU D CD2 1 
ATOM   7372 N  N   . HIS D 1 117 ? 3.262   1.675   -38.872 1.00 3.98  ? 117 HIS D N   1 
ATOM   7373 C  CA  . HIS D 1 117 ? 2.975   2.460   -37.679 1.00 3.92  ? 117 HIS D CA  1 
ATOM   7374 C  C   . HIS D 1 117 ? 1.571   3.090   -37.770 1.00 3.94  ? 117 HIS D C   1 
ATOM   7375 O  O   . HIS D 1 117 ? 1.236   3.711   -38.805 1.00 4.98  ? 117 HIS D O   1 
ATOM   7376 C  CB  . HIS D 1 117 ? 3.983   3.584   -37.566 1.00 4.07  ? 117 HIS D CB  1 
ATOM   7377 C  CG  . HIS D 1 117 ? 5.312   3.099   -37.203 1.00 4.28  ? 117 HIS D CG  1 
ATOM   7378 N  ND1 . HIS D 1 117 ? 6.463   3.847   -37.454 1.00 4.52  ? 117 HIS D ND1 1 
ATOM   7379 C  CD2 . HIS D 1 117 ? 5.730   1.872   -36.617 1.00 5.20  ? 117 HIS D CD2 1 
ATOM   7380 C  CE1 . HIS D 1 117 ? 7.518   3.128   -37.009 1.00 4.75  ? 117 HIS D CE1 1 
ATOM   7381 N  NE2 . HIS D 1 117 ? 7.097   1.917   -36.549 1.00 4.38  ? 117 HIS D NE2 1 
ATOM   7382 N  N   . ILE D 1 118 ? 0.773   2.838   -36.741 1.00 4.37  ? 118 ILE D N   1 
ATOM   7383 C  CA  . ILE D 1 118 ? -0.557  3.557   -36.630 1.00 4.80  ? 118 ILE D CA  1 
ATOM   7384 C  C   . ILE D 1 118 ? -0.458  4.550   -35.560 1.00 4.56  ? 118 ILE D C   1 
ATOM   7385 O  O   . ILE D 1 118 ? -0.246  4.201   -34.380 1.00 4.26  ? 118 ILE D O   1 
ATOM   7386 C  CB  . ILE D 1 118 ? -1.652  2.488   -36.381 1.00 5.13  ? 118 ILE D CB  1 
ATOM   7387 C  CG1 . ILE D 1 118 ? -1.572  1.307   -37.401 1.00 5.56  ? 118 ILE D CG1 1 
ATOM   7388 C  CG2 . ILE D 1 118 ? -3.037  3.227   -36.469 1.00 5.76  ? 118 ILE D CG2 1 
ATOM   7389 C  CD1 . ILE D 1 118 ? -2.694  0.245   -37.143 1.00 8.09  ? 118 ILE D CD1 1 
ATOM   7390 N  N   . VAL D 1 119 ? -0.468  5.825   -35.958 1.00 4.38  ? 119 VAL D N   1 
ATOM   7391 C  CA  . VAL D 1 119 ? -0.190  6.932   -35.036 1.00 4.99  ? 119 VAL D CA  1 
ATOM   7392 C  C   . VAL D 1 119 ? -1.529  7.409   -34.426 1.00 4.70  ? 119 VAL D C   1 
ATOM   7393 O  O   . VAL D 1 119 ? -2.497  7.657   -35.185 1.00 5.23  ? 119 VAL D O   1 
ATOM   7394 C  CB  . VAL D 1 119 ? 0.482   8.106   -35.819 1.00 5.23  ? 119 VAL D CB  1 
ATOM   7395 C  CG1 . VAL D 1 119 ? 0.839   9.225   -34.845 1.00 6.25  ? 119 VAL D CG1 1 
ATOM   7396 C  CG2 . VAL D 1 119 ? 1.774   7.621   -36.497 1.00 5.55  ? 119 VAL D CG2 1 
ATOM   7397 N  N   . HIS D 1 120 ? -1.495  7.549   -33.112 1.00 5.00  ? 120 HIS D N   1 
ATOM   7398 C  CA  . HIS D 1 120 ? -2.626  8.125   -32.362 1.00 5.83  ? 120 HIS D CA  1 
ATOM   7399 C  C   . HIS D 1 120 ? -2.124  9.227   -31.477 1.00 5.99  ? 120 HIS D C   1 
ATOM   7400 O  O   . HIS D 1 120 ? -0.977  9.299   -31.096 1.00 6.27  ? 120 HIS D O   1 
ATOM   7401 C  CB  . HIS D 1 120 ? -3.238  7.052   -31.421 1.00 6.27  ? 120 HIS D CB  1 
ATOM   7402 C  CG  . HIS D 1 120 ? -3.666  5.798   -32.134 1.00 5.98  ? 120 HIS D CG  1 
ATOM   7403 N  ND1 . HIS D 1 120 ? -2.734  4.856   -32.667 1.00 6.19  ? 120 HIS D ND1 1 
ATOM   7404 C  CD2 . HIS D 1 120 ? -4.915  5.208   -32.231 1.00 6.52  ? 120 HIS D CD2 1 
ATOM   7405 C  CE1 . HIS D 1 120 ? -3.460  3.796   -33.188 1.00 5.95  ? 120 HIS D CE1 1 
ATOM   7406 N  NE2 . HIS D 1 120 ? -4.774  3.981   -32.937 1.00 6.61  ? 120 HIS D NE2 1 
ATOM   7407 N  N   . TYR D 1 121 ? -3.072  10.139  -31.177 1.00 6.03  ? 121 TYR D N   1 
ATOM   7408 C  CA  . TYR D 1 121 ? -2.733  11.275  -30.289 1.00 6.11  ? 121 TYR D CA  1 
ATOM   7409 C  C   . TYR D 1 121 ? -3.658  11.300  -29.073 1.00 5.99  ? 121 TYR D C   1 
ATOM   7410 O  O   . TYR D 1 121 ? -4.804  10.815  -29.098 1.00 5.86  ? 121 TYR D O   1 
ATOM   7411 C  CB  . TYR D 1 121 ? -2.811  12.614  -31.089 1.00 7.25  ? 121 TYR D CB  1 
ATOM   7412 C  CG  . TYR D 1 121 ? -4.205  13.051  -31.435 1.00 7.07  ? 121 TYR D CG  1 
ATOM   7413 C  CD1 . TYR D 1 121 ? -4.809  14.042  -30.662 1.00 7.48  ? 121 TYR D CD1 1 
ATOM   7414 C  CD2 . TYR D 1 121 ? -4.857  12.545  -32.552 1.00 8.97  ? 121 TYR D CD2 1 
ATOM   7415 C  CE1 . TYR D 1 121 ? -6.090  14.424  -30.911 1.00 9.41  ? 121 TYR D CE1 1 
ATOM   7416 C  CE2 . TYR D 1 121 ? -6.145  12.934  -32.835 1.00 9.24  ? 121 TYR D CE2 1 
ATOM   7417 C  CZ  . TYR D 1 121 ? -6.760  13.851  -31.973 1.00 9.74  ? 121 TYR D CZ  1 
ATOM   7418 O  OH  . TYR D 1 121 ? -8.066  14.227  -32.357 1.00 14.41 ? 121 TYR D OH  1 
ATOM   7419 N  N   . ASN D 1 122 ? -3.187  12.011  -28.074 1.00 6.49  ? 122 ASN D N   1 
ATOM   7420 C  CA  . ASN D 1 122 ? -3.887  12.049  -26.770 1.00 6.91  ? 122 ASN D CA  1 
ATOM   7421 C  C   . ASN D 1 122 ? -5.036  13.082  -26.848 1.00 7.65  ? 122 ASN D C   1 
ATOM   7422 O  O   . ASN D 1 122 ? -4.788  14.288  -26.642 1.00 8.95  ? 122 ASN D O   1 
ATOM   7423 C  CB  . ASN D 1 122 ? -2.911  12.375  -25.666 1.00 7.13  ? 122 ASN D CB  1 
ATOM   7424 C  CG  . ASN D 1 122 ? -3.543  12.225  -24.304 1.00 8.05  ? 122 ASN D CG  1 
ATOM   7425 O  OD1 . ASN D 1 122 ? -4.751  12.378  -24.138 1.00 8.24  ? 122 ASN D OD1 1 
ATOM   7426 N  ND2 . ASN D 1 122 ? -2.723  11.910  -23.316 1.00 10.45 ? 122 ASN D ND2 1 
ATOM   7427 N  N   . SER D 1 123 ? -6.221  12.600  -27.208 1.00 7.09  ? 123 SER D N   1 
ATOM   7428 C  CA  . SER D 1 123 ? -7.356  13.487  -27.407 1.00 8.29  ? 123 SER D CA  1 
ATOM   7429 C  C   . SER D 1 123 ? -8.025  13.856  -26.106 1.00 9.17  ? 123 SER D C   1 
ATOM   7430 O  O   . SER D 1 123 ? -8.857  14.794  -26.115 1.00 12.15 ? 123 SER D O   1 
ATOM   7431 C  CB  . SER D 1 123 ? -8.307  12.881  -28.414 1.00 8.71  ? 123 SER D CB  1 
ATOM   7432 O  OG  . SER D 1 123 ? -8.631  11.537  -28.032 1.00 11.51 ? 123 SER D OG  1 
ATOM   7433 N  N   . ASP D 1 124 ? -7.606  13.292  -24.976 1.00 8.47  ? 124 ASP D N   1 
ATOM   7434 C  CA  . ASP D 1 124 ? -8.081  13.761  -23.662 1.00 8.96  ? 124 ASP D CA  1 
ATOM   7435 C  C   . ASP D 1 124 ? -7.344  15.064  -23.333 1.00 11.46 ? 124 ASP D C   1 
ATOM   7436 O  O   . ASP D 1 124 ? -7.905  15.869  -22.550 1.00 15.55 ? 124 ASP D O   1 
ATOM   7437 C  CB  . ASP D 1 124 ? -7.742  12.694  -22.594 1.00 10.65 ? 124 ASP D CB  1 
ATOM   7438 C  CG  . ASP D 1 124 ? -8.667  11.492  -22.657 1.00 11.55 ? 124 ASP D CG  1 
ATOM   7439 O  OD1 . ASP D 1 124 ? -9.655  11.541  -23.417 1.00 12.70 ? 124 ASP D OD1 1 
ATOM   7440 O  OD2 . ASP D 1 124 ? -8.397  10.506  -21.939 1.00 12.82 ? 124 ASP D OD2 1 
ATOM   7441 N  N   . LEU D 1 125 ? -6.161  15.299  -23.865 1.00 9.88  ? 125 LEU D N   1 
ATOM   7442 C  CA  . LEU D 1 125 ? -5.315  16.454  -23.498 1.00 9.94  ? 125 LEU D CA  1 
ATOM   7443 C  C   . LEU D 1 125 ? -5.254  17.468  -24.610 1.00 10.27 ? 125 LEU D C   1 
ATOM   7444 O  O   . LEU D 1 125 ? -5.091  18.638  -24.320 1.00 11.30 ? 125 LEU D O   1 
ATOM   7445 C  CB  . LEU D 1 125 ? -3.905  16.030  -23.128 1.00 10.72 ? 125 LEU D CB  1 
ATOM   7446 C  CG  . LEU D 1 125 ? -3.668  15.553  -21.703 1.00 13.50 ? 125 LEU D CG  1 
ATOM   7447 C  CD1 . LEU D 1 125 ? -4.554  14.417  -21.227 1.00 16.30 ? 125 LEU D CD1 1 
ATOM   7448 C  CD2 . LEU D 1 125 ? -2.206  15.234  -21.505 1.00 13.67 ? 125 LEU D CD2 1 
ATOM   7449 N  N   . TYR D 1 126 ? -5.339  17.045  -25.865 1.00 9.28  ? 126 TYR D N   1 
ATOM   7450 C  CA  . TYR D 1 126 ? -4.967  17.864  -26.994 1.00 10.45 ? 126 TYR D CA  1 
ATOM   7451 C  C   . TYR D 1 126 ? -6.030  17.840  -28.062 1.00 11.19 ? 126 TYR D C   1 
ATOM   7452 O  O   . TYR D 1 126 ? -6.687  16.804  -28.310 1.00 11.35 ? 126 TYR D O   1 
ATOM   7453 C  CB  . TYR D 1 126 ? -3.612  17.378  -27.558 1.00 8.90  ? 126 TYR D CB  1 
ATOM   7454 C  CG  . TYR D 1 126 ? -2.533  17.424  -26.513 1.00 7.72  ? 126 TYR D CG  1 
ATOM   7455 C  CD1 . TYR D 1 126 ? -2.185  18.582  -25.847 1.00 8.21  ? 126 TYR D CD1 1 
ATOM   7456 C  CD2 . TYR D 1 126 ? -1.876  16.205  -26.127 1.00 8.51  ? 126 TYR D CD2 1 
ATOM   7457 C  CE1 . TYR D 1 126 ? -1.226  18.562  -24.842 1.00 8.48  ? 126 TYR D CE1 1 
ATOM   7458 C  CE2 . TYR D 1 126 ? -0.941  16.147  -25.127 1.00 8.70  ? 126 TYR D CE2 1 
ATOM   7459 C  CZ  . TYR D 1 126 ? -0.653  17.327  -24.418 1.00 8.43  ? 126 TYR D CZ  1 
ATOM   7460 O  OH  . TYR D 1 126 ? 0.309   17.270  -23.412 1.00 9.64  ? 126 TYR D OH  1 
ATOM   7461 N  N   . PRO D 1 127 ? -6.145  18.992  -28.808 1.00 12.28 ? 127 PRO D N   1 
ATOM   7462 C  CA  . PRO D 1 127 ? -7.290  19.130  -29.747 1.00 15.36 ? 127 PRO D CA  1 
ATOM   7463 C  C   . PRO D 1 127 ? -7.010  18.477  -31.026 1.00 17.48 ? 127 PRO D C   1 
ATOM   7464 O  O   . PRO D 1 127 ? -7.908  18.337  -31.817 1.00 21.06 ? 127 PRO D O   1 
ATOM   7465 C  CB  . PRO D 1 127 ? -7.305  20.642  -30.064 1.00 17.28 ? 127 PRO D CB  1 
ATOM   7466 C  CG  . PRO D 1 127 ? -6.008  21.208  -29.586 1.00 15.50 ? 127 PRO D CG  1 
ATOM   7467 C  CD  . PRO D 1 127 ? -5.461  20.259  -28.488 1.00 14.28 ? 127 PRO D CD  1 
ATOM   7468 N  N   . ASP D 1 128 ? -5.756  18.151  -31.296 1.00 14.26 ? 128 ASP D N   1 
ATOM   7469 C  CA  . ASP D 1 128 ? -5.329  17.566  -32.549 1.00 14.63 ? 128 ASP D CA  1 
ATOM   7470 C  C   . ASP D 1 128 ? -3.908  17.020  -32.492 1.00 13.54 ? 128 ASP D C   1 
ATOM   7471 O  O   . ASP D 1 128 ? -3.113  17.298  -31.534 1.00 12.39 ? 128 ASP D O   1 
ATOM   7472 C  CB  . ASP D 1 128 ? -5.450  18.627  -33.694 1.00 16.21 ? 128 ASP D CB  1 
ATOM   7473 C  CG  . ASP D 1 128 ? -4.565  19.815  -33.445 1.00 21.84 ? 128 ASP D CG  1 
ATOM   7474 O  OD1 . ASP D 1 128 ? -4.964  20.853  -32.789 1.00 24.29 ? 128 ASP D OD1 1 
ATOM   7475 O  OD2 . ASP D 1 128 ? -3.408  19.694  -33.755 1.00 21.37 ? 128 ASP D OD2 1 
ATOM   7476 N  N   . ALA D 1 129 ? -3.531  16.174  -33.461 1.00 11.88 ? 129 ALA D N   1 
ATOM   7477 C  CA  . ALA D 1 129 ? -2.316  15.518  -33.394 1.00 10.55 ? 129 ALA D CA  1 
ATOM   7478 C  C   . ALA D 1 129 ? -1.056  16.392  -33.500 1.00 10.61 ? 129 ALA D C   1 
ATOM   7479 O  O   . ALA D 1 129 ? -0.011  16.152  -32.855 1.00 10.25 ? 129 ALA D O   1 
ATOM   7480 C  CB  . ALA D 1 129 ? -2.189  14.401  -34.451 1.00 14.75 ? 129 ALA D CB  1 
ATOM   7481 N  N   A SER D 1 130 ? -1.208  17.454  -34.333 0.50 11.78 ? 130 SER D N   1 
ATOM   7482 N  N   B SER D 1 130 ? -1.127  17.441  -34.351 0.50 10.99 ? 130 SER D N   1 
ATOM   7483 C  CA  A SER D 1 130 ? -0.133  18.428  -34.506 0.50 11.64 ? 130 SER D CA  1 
ATOM   7484 C  CA  B SER D 1 130 ? 0.069   18.274  -34.488 0.50 10.29 ? 130 SER D CA  1 
ATOM   7485 C  C   A SER D 1 130 ? 0.229   18.968  -33.117 0.50 9.96  ? 130 SER D C   1 
ATOM   7486 C  C   B SER D 1 130 ? 0.291   19.077  -33.150 0.50 9.39  ? 130 SER D C   1 
ATOM   7487 O  O   A SER D 1 130 ? 1.378   18.838  -32.639 0.50 11.13 ? 130 SER D O   1 
ATOM   7488 O  O   B SER D 1 130 ? 1.467   19.258  -32.733 0.50 11.13 ? 130 SER D O   1 
ATOM   7489 C  CB  A SER D 1 130 ? -0.597  19.581  -35.425 0.50 12.97 ? 130 SER D CB  1 
ATOM   7490 C  CB  B SER D 1 130 ? -0.035  19.148  -35.748 0.50 9.83  ? 130 SER D CB  1 
ATOM   7491 O  OG  A SER D 1 130 ? -0.551  19.162  -36.771 0.50 17.87 ? 130 SER D OG  1 
ATOM   7492 O  OG  B SER D 1 130 ? 0.927   20.134  -35.787 0.50 12.17 ? 130 SER D OG  1 
ATOM   7493 N  N   . THR D 1 131 ? -0.785  19.506  -32.469 1.00 10.42 ? 131 THR D N   1 
ATOM   7494 C  CA  . THR D 1 131 ? -0.604  20.137  -31.144 1.00 9.92  ? 131 THR D CA  1 
ATOM   7495 C  C   . THR D 1 131 ? -0.027  19.135  -30.145 1.00 9.82  ? 131 THR D C   1 
ATOM   7496 O  O   . THR D 1 131 ? 0.846   19.434  -29.292 1.00 10.63 ? 131 THR D O   1 
ATOM   7497 C  CB  . THR D 1 131 ? -1.925  20.624  -30.645 1.00 12.19 ? 131 THR D CB  1 
ATOM   7498 O  OG1 . THR D 1 131 ? -2.433  21.634  -31.580 1.00 14.11 ? 131 THR D OG1 1 
ATOM   7499 C  CG2 . THR D 1 131 ? -1.772  21.272  -29.249 1.00 14.16 ? 131 THR D CG2 1 
ATOM   7500 N  N   . ALA D 1 132 ? -0.529  17.891  -30.196 1.00 9.21  ? 132 ALA D N   1 
ATOM   7501 C  CA  . ALA D 1 132 ? -0.057  16.885  -29.287 1.00 7.89  ? 132 ALA D CA  1 
ATOM   7502 C  C   . ALA D 1 132 ? 1.395   16.440  -29.456 1.00 8.12  ? 132 ALA D C   1 
ATOM   7503 O  O   . ALA D 1 132 ? 2.099   15.972  -28.531 1.00 7.93  ? 132 ALA D O   1 
ATOM   7504 C  CB  . ALA D 1 132 ? -0.879  15.590  -29.497 1.00 8.26  ? 132 ALA D CB  1 
ATOM   7505 N  N   . SER D 1 133 ? 1.834   16.525  -30.721 1.00 8.60  ? 133 SER D N   1 
ATOM   7506 C  CA  . SER D 1 133 ? 3.087   15.886  -31.075 1.00 9.50  ? 133 SER D CA  1 
ATOM   7507 C  C   . SER D 1 133 ? 4.362   16.302  -30.319 1.00 9.96  ? 133 SER D C   1 
ATOM   7508 O  O   . SER D 1 133 ? 5.328   15.517  -30.199 1.00 9.59  ? 133 SER D O   1 
ATOM   7509 C  CB  . SER D 1 133 ? 3.318   15.942  -32.609 1.00 9.86  ? 133 SER D CB  1 
ATOM   7510 O  OG  . SER D 1 133 ? 3.654   17.302  -32.976 1.00 13.10 ? 133 SER D OG  1 
ATOM   7511 N  N   . ASN D 1 134 ? 4.373   17.562  -29.808 1.00 9.71  ? 134 ASN D N   1 
ATOM   7512 C  CA  . ASN D 1 134 ? 5.503   18.009  -29.000 1.00 10.60 ? 134 ASN D CA  1 
ATOM   7513 C  C   . ASN D 1 134 ? 5.240   18.200  -27.599 1.00 11.28 ? 134 ASN D C   1 
ATOM   7514 O  O   . ASN D 1 134 ? 6.018   18.832  -26.898 1.00 13.69 ? 134 ASN D O   1 
ATOM   7515 C  CB  . ASN D 1 134 ? 6.186   19.231  -29.607 1.00 12.76 ? 134 ASN D CB  1 
ATOM   7516 C  CG  . ASN D 1 134 ? 5.310   20.446  -29.488 1.00 16.09 ? 134 ASN D CG  1 
ATOM   7517 O  OD1 . ASN D 1 134 ? 4.091   20.353  -29.444 1.00 14.45 ? 134 ASN D OD1 1 
ATOM   7518 N  ND2 . ASN D 1 134 ? 5.951   21.644  -29.408 1.00 16.78 ? 134 ASN D ND2 1 
ATOM   7519 N  N   . LYS D 1 135 ? 4.212   17.544  -27.125 1.00 9.90  ? 135 LYS D N   1 
ATOM   7520 C  CA  . LYS D 1 135 ? 3.752   17.752  -25.731 1.00 9.17  ? 135 LYS D CA  1 
ATOM   7521 C  C   . LYS D 1 135 ? 3.657   16.491  -24.944 1.00 9.82  ? 135 LYS D C   1 
ATOM   7522 O  O   . LYS D 1 135 ? 3.616   15.376  -25.492 1.00 9.07  ? 135 LYS D O   1 
ATOM   7523 C  CB  . LYS D 1 135 ? 2.376   18.460  -25.782 1.00 9.56  ? 135 LYS D CB  1 
ATOM   7524 C  CG  . LYS D 1 135 ? 2.561   19.902  -26.284 1.00 10.26 ? 135 LYS D CG  1 
ATOM   7525 C  CD  . LYS D 1 135 ? 1.250   20.698  -26.283 1.00 10.94 ? 135 LYS D CD  1 
ATOM   7526 C  CE  . LYS D 1 135 ? 1.472   22.057  -27.007 1.00 11.81 ? 135 LYS D CE  1 
ATOM   7527 N  NZ  . LYS D 1 135 ? 1.883   21.890  -28.460 1.00 13.10 ? 135 LYS D NZ  1 
ATOM   7528 N  N   A SER D 1 136 ? 3.660   16.639  -23.620 0.50 9.36  ? 136 SER D N   1 
ATOM   7529 N  N   B SER D 1 136 ? 3.651   16.649  -23.613 0.50 9.90  ? 136 SER D N   1 
ATOM   7530 C  CA  A SER D 1 136 ? 3.747   15.491  -22.749 0.50 9.14  ? 136 SER D CA  1 
ATOM   7531 C  CA  B SER D 1 136 ? 3.574   15.539  -22.664 0.50 10.14 ? 136 SER D CA  1 
ATOM   7532 C  C   A SER D 1 136 ? 2.607   14.516  -23.008 0.50 8.50  ? 136 SER D C   1 
ATOM   7533 C  C   B SER D 1 136 ? 2.528   14.498  -22.999 0.50 8.94  ? 136 SER D C   1 
ATOM   7534 O  O   A SER D 1 136 ? 1.443   14.885  -23.165 0.50 8.53  ? 136 SER D O   1 
ATOM   7535 O  O   B SER D 1 136 ? 1.327   14.807  -23.154 0.50 8.87  ? 136 SER D O   1 
ATOM   7536 C  CB  A SER D 1 136 ? 3.621   16.024  -21.334 0.50 9.27  ? 136 SER D CB  1 
ATOM   7537 C  CB  B SER D 1 136 ? 3.164   16.164  -21.323 0.50 10.61 ? 136 SER D CB  1 
ATOM   7538 O  OG  A SER D 1 136 ? 3.609   14.964  -20.414 0.50 10.29 ? 136 SER D OG  1 
ATOM   7539 O  OG  B SER D 1 136 ? 4.246   16.814  -20.686 0.50 14.70 ? 136 SER D OG  1 
ATOM   7540 N  N   . GLU D 1 137 ? 2.958   13.226  -23.052 1.00 9.06  ? 137 GLU D N   1 
ATOM   7541 C  CA  . GLU D 1 137 ? 1.987   12.149  -23.257 1.00 8.89  ? 137 GLU D CA  1 
ATOM   7542 C  C   . GLU D 1 137 ? 1.246   12.300  -24.564 1.00 7.09  ? 137 GLU D C   1 
ATOM   7543 O  O   . GLU D 1 137 ? 0.105   11.853  -24.729 1.00 7.79  ? 137 GLU D O   1 
ATOM   7544 C  CB  . GLU D 1 137 ? 0.948   11.986  -22.125 1.00 10.52 ? 137 GLU D CB  1 
ATOM   7545 C  CG  . GLU D 1 137 ? 1.662   12.013  -20.745 1.00 14.61 ? 137 GLU D CG  1 
ATOM   7546 C  CD  . GLU D 1 137 ? 2.470   10.756  -20.498 1.00 20.76 ? 137 GLU D CD  1 
ATOM   7547 O  OE1 . GLU D 1 137 ? 2.213   9.688   -21.105 1.00 24.58 ? 137 GLU D OE1 1 
ATOM   7548 O  OE2 . GLU D 1 137 ? 3.440   10.864  -19.717 1.00 30.41 ? 137 GLU D OE2 1 
ATOM   7549 N  N   . GLY D 1 138 ? 1.820   12.990  -25.551 1.00 6.25  ? 138 GLY D N   1 
ATOM   7550 C  CA  . GLY D 1 138 ? 1.028   13.369  -26.680 1.00 6.08  ? 138 GLY D CA  1 
ATOM   7551 C  C   . GLY D 1 138 ? 0.618   12.258  -27.658 1.00 5.60  ? 138 GLY D C   1 
ATOM   7552 O  O   . GLY D 1 138 ? -0.422  12.388  -28.274 1.00 6.36  ? 138 GLY D O   1 
ATOM   7553 N  N   . LEU D 1 139 ? 1.491   11.275  -27.843 1.00 5.72  ? 139 LEU D N   1 
ATOM   7554 C  CA  . LEU D 1 139 ? 1.227   10.300  -28.958 1.00 5.96  ? 139 LEU D CA  1 
ATOM   7555 C  C   . LEU D 1 139 ? 1.382   8.839   -28.479 1.00 6.09  ? 139 LEU D C   1 
ATOM   7556 O  O   . LEU D 1 139 ? 2.129   8.554   -27.511 1.00 6.50  ? 139 LEU D O   1 
ATOM   7557 C  CB  . LEU D 1 139 ? 2.272   10.476  -30.103 1.00 6.39  ? 139 LEU D CB  1 
ATOM   7558 C  CG  . LEU D 1 139 ? 2.261   11.850  -30.744 1.00 6.65  ? 139 LEU D CG  1 
ATOM   7559 C  CD1 . LEU D 1 139 ? 3.542   11.941  -31.623 1.00 7.29  ? 139 LEU D CD1 1 
ATOM   7560 C  CD2 . LEU D 1 139 ? 0.986   12.190  -31.516 1.00 8.49  ? 139 LEU D CD2 1 
ATOM   7561 N  N   . ALA D 1 140 ? 0.651   7.960   -29.161 1.00 6.00  ? 140 ALA D N   1 
ATOM   7562 C  CA  . ALA D 1 140 ? 0.852   6.500   -28.942 1.00 5.26  ? 140 ALA D CA  1 
ATOM   7563 C  C   . ALA D 1 140 ? 0.875   5.947   -30.321 1.00 5.32  ? 140 ALA D C   1 
ATOM   7564 O  O   . ALA D 1 140 ? -0.008  6.199   -31.161 1.00 6.63  ? 140 ALA D O   1 
ATOM   7565 C  CB  . ALA D 1 140 ? -0.313  5.955   -28.151 1.00 6.30  ? 140 ALA D CB  1 
ATOM   7566 N  N   . VAL D 1 141 ? 1.927   5.171   -30.619 1.00 5.21  ? 141 VAL D N   1 
ATOM   7567 C  CA  . VAL D 1 141 ? 2.035   4.507   -31.908 1.00 5.17  ? 141 VAL D CA  1 
ATOM   7568 C  C   . VAL D 1 141 ? 1.947   2.994   -31.730 1.00 5.33  ? 141 VAL D C   1 
ATOM   7569 O  O   . VAL D 1 141 ? 2.602   2.472   -30.824 1.00 6.24  ? 141 VAL D O   1 
ATOM   7570 C  CB  . VAL D 1 141 ? 3.315   4.932   -32.602 1.00 4.72  ? 141 VAL D CB  1 
ATOM   7571 C  CG1 . VAL D 1 141 ? 3.408   4.282   -34.022 1.00 5.63  ? 141 VAL D CG1 1 
ATOM   7572 C  CG2 . VAL D 1 141 ? 3.344   6.473   -32.768 1.00 5.91  ? 141 VAL D CG2 1 
ATOM   7573 N  N   . LEU D 1 142 ? 1.209   2.345   -32.617 1.00 5.11  ? 142 LEU D N   1 
ATOM   7574 C  CA  . LEU D 1 142 ? 1.208   0.877   -32.684 1.00 5.14  ? 142 LEU D CA  1 
ATOM   7575 C  C   . LEU D 1 142 ? 2.081   0.484   -33.835 1.00 5.52  ? 142 LEU D C   1 
ATOM   7576 O  O   . LEU D 1 142 ? 2.016   1.053   -34.918 1.00 6.54  ? 142 LEU D O   1 
ATOM   7577 C  CB  . LEU D 1 142 ? -0.221  0.424   -32.981 1.00 6.44  ? 142 LEU D CB  1 
ATOM   7578 C  CG  . LEU D 1 142 ? -1.332  0.738   -32.028 1.00 7.62  ? 142 LEU D CG  1 
ATOM   7579 C  CD1 . LEU D 1 142 ? -2.621  0.028   -32.487 1.00 8.16  ? 142 LEU D CD1 1 
ATOM   7580 C  CD2 . LEU D 1 142 ? -0.970  0.466   -30.542 1.00 8.44  ? 142 LEU D CD2 1 
ATOM   7581 N  N   . ALA D 1 143 ? 3.034   -0.411  -33.561 1.00 5.44  ? 143 ALA D N   1 
ATOM   7582 C  CA  . ALA D 1 143 ? 3.981   -0.902  -34.566 1.00 4.82  ? 143 ALA D CA  1 
ATOM   7583 C  C   . ALA D 1 143 ? 3.765   -2.385  -34.847 1.00 4.47  ? 143 ALA D C   1 
ATOM   7584 O  O   . ALA D 1 143 ? 3.711   -3.211  -33.912 1.00 4.88  ? 143 ALA D O   1 
ATOM   7585 C  CB  . ALA D 1 143 ? 5.405   -0.665  -34.076 1.00 4.69  ? 143 ALA D CB  1 
ATOM   7586 N  N   . VAL D 1 144 ? 3.611   -2.641  -36.099 1.00 4.37  ? 144 VAL D N   1 
ATOM   7587 C  CA  . VAL D 1 144 ? 3.483   -4.044  -36.631 1.00 4.48  ? 144 VAL D CA  1 
ATOM   7588 C  C   . VAL D 1 144 ? 4.689   -4.314  -37.490 1.00 4.32  ? 144 VAL D C   1 
ATOM   7589 O  O   . VAL D 1 144 ? 4.985   -3.615  -38.451 1.00 4.66  ? 144 VAL D O   1 
ATOM   7590 C  CB  . VAL D 1 144 ? 2.229   -4.194  -37.483 1.00 5.02  ? 144 VAL D CB  1 
ATOM   7591 C  CG1 . VAL D 1 144 ? 2.130   -5.660  -37.867 1.00 5.79  ? 144 VAL D CG1 1 
ATOM   7592 C  CG2 . VAL D 1 144 ? 0.989   -3.724  -36.731 1.00 5.88  ? 144 VAL D CG2 1 
ATOM   7593 N  N   . LEU D 1 145 ? 5.434   -5.365  -37.067 1.00 4.48  ? 145 LEU D N   1 
ATOM   7594 C  CA  . LEU D 1 145 ? 6.631   -5.835  -37.817 1.00 5.18  ? 145 LEU D CA  1 
ATOM   7595 C  C   . LEU D 1 145 ? 6.139   -6.682  -39.000 1.00 5.12  ? 145 LEU D C   1 
ATOM   7596 O  O   . LEU D 1 145 ? 5.148   -7.433  -38.826 1.00 5.62  ? 145 LEU D O   1 
ATOM   7597 C  CB  . LEU D 1 145 ? 7.525   -6.602  -36.883 1.00 7.01  ? 145 LEU D CB  1 
ATOM   7598 C  CG  . LEU D 1 145 ? 8.015   -5.856  -35.677 1.00 8.74  ? 145 LEU D CG  1 
ATOM   7599 C  CD1 . LEU D 1 145 ? 8.540   -6.840  -34.624 1.00 10.83 ? 145 LEU D CD1 1 
ATOM   7600 C  CD2 . LEU D 1 145 ? 9.061   -4.858  -36.158 1.00 10.69 ? 145 LEU D CD2 1 
ATOM   7601 N  N   . ILE D 1 146 ? 6.742   -6.456  -40.140 1.00 5.68  ? 146 ILE D N   1 
ATOM   7602 C  CA  . ILE D 1 146 ? 6.298   -7.073  -41.378 1.00 5.60  ? 146 ILE D CA  1 
ATOM   7603 C  C   . ILE D 1 146 ? 7.390   -7.930  -41.962 1.00 6.33  ? 146 ILE D C   1 
ATOM   7604 O  O   . ILE D 1 146 ? 8.502   -7.467  -42.201 1.00 6.21  ? 146 ILE D O   1 
ATOM   7605 C  CB  . ILE D 1 146 ? 5.932   -5.981  -42.437 1.00 5.53  ? 146 ILE D CB  1 
ATOM   7606 C  CG1 . ILE D 1 146 ? 4.712   -5.184  -41.958 1.00 6.68  ? 146 ILE D CG1 1 
ATOM   7607 C  CG2 . ILE D 1 146 ? 5.536   -6.662  -43.767 1.00 6.28  ? 146 ILE D CG2 1 
ATOM   7608 C  CD1 . ILE D 1 146 ? 4.413   -3.967  -42.766 1.00 6.70  ? 146 ILE D CD1 1 
ATOM   7609 N  N   A GLU D 1 147 ? 7.047   -9.197  -42.268 0.50 6.62  ? 147 GLU D N   1 
ATOM   7610 N  N   B GLU D 1 147 ? 7.164   -9.245  -42.114 0.50 6.65  ? 147 GLU D N   1 
ATOM   7611 C  CA  A GLU D 1 147 ? 8.021   -10.205 -42.762 0.50 7.60  ? 147 GLU D CA  1 
ATOM   7612 C  CA  B GLU D 1 147 ? 8.231   -10.077 -42.743 0.50 7.45  ? 147 GLU D CA  1 
ATOM   7613 C  C   A GLU D 1 147 ? 7.674   -10.502 -44.211 0.50 6.73  ? 147 GLU D C   1 
ATOM   7614 C  C   B GLU D 1 147 ? 7.749   -10.545 -44.102 0.50 6.72  ? 147 GLU D C   1 
ATOM   7615 O  O   A GLU D 1 147 ? 6.489   -10.390 -44.641 0.50 6.70  ? 147 GLU D O   1 
ATOM   7616 O  O   B GLU D 1 147 ? 6.553   -10.604 -44.329 0.50 6.74  ? 147 GLU D O   1 
ATOM   7617 C  CB  A GLU D 1 147 ? 7.860   -11.505 -41.981 0.50 9.30  ? 147 GLU D CB  1 
ATOM   7618 C  CB  B GLU D 1 147 ? 8.507   -11.316 -41.907 0.50 9.68  ? 147 GLU D CB  1 
ATOM   7619 C  CG  A GLU D 1 147 ? 8.882   -12.577 -42.285 0.50 12.87 ? 147 GLU D CG  1 
ATOM   7620 C  CG  B GLU D 1 147 ? 7.320   -12.190 -41.674 0.50 12.19 ? 147 GLU D CG  1 
ATOM   7621 C  CD  A GLU D 1 147 ? 8.868   -13.664 -41.195 0.50 17.24 ? 147 GLU D CD  1 
ATOM   7622 C  CD  B GLU D 1 147 ? 7.612   -13.363 -40.695 0.50 14.83 ? 147 GLU D CD  1 
ATOM   7623 O  OE1 A GLU D 1 147 ? 8.427   -13.372 -40.059 0.50 21.81 ? 147 GLU D OE1 1 
ATOM   7624 O  OE1 B GLU D 1 147 ? 6.926   -14.408 -40.764 0.50 19.05 ? 147 GLU D OE1 1 
ATOM   7625 O  OE2 A GLU D 1 147 ? 9.319   -14.805 -41.439 0.50 20.97 ? 147 GLU D OE2 1 
ATOM   7626 O  OE2 B GLU D 1 147 ? 8.543   -13.212 -39.851 0.50 18.45 ? 147 GLU D OE2 1 
ATOM   7627 N  N   . MET D 1 148 ? 8.697   -10.834 -45.006 1.00 6.99  ? 148 MET D N   1 
ATOM   7628 C  CA  . MET D 1 148 ? 8.388   -11.376 -46.311 1.00 8.19  ? 148 MET D CA  1 
ATOM   7629 C  C   . MET D 1 148 ? 7.781   -12.748 -46.188 1.00 7.93  ? 148 MET D C   1 
ATOM   7630 O  O   . MET D 1 148 ? 8.402   -13.625 -45.560 1.00 9.36  ? 148 MET D O   1 
ATOM   7631 C  CB  . MET D 1 148 ? 9.694   -11.508 -47.119 1.00 9.12  ? 148 MET D CB  1 
ATOM   7632 C  CG  . MET D 1 148 ? 9.419   -11.867 -48.559 1.00 10.68 ? 148 MET D CG  1 
ATOM   7633 S  SD  . MET D 1 148 ? 10.978  -11.852 -49.513 1.00 12.87 ? 148 MET D SD  1 
ATOM   7634 C  CE  . MET D 1 148 ? 11.527  -10.143 -49.422 1.00 13.62 ? 148 MET D CE  1 
ATOM   7635 N  N   . GLY D 1 149 ? 6.618   -12.934 -46.802 1.00 7.37  ? 149 GLY D N   1 
ATOM   7636 C  CA  . GLY D 1 149 ? 5.899   -14.244 -46.697 1.00 6.72  ? 149 GLY D CA  1 
ATOM   7637 C  C   . GLY D 1 149 ? 4.782   -14.320 -47.737 1.00 5.50  ? 149 GLY D C   1 
ATOM   7638 O  O   . GLY D 1 149 ? 4.951   -14.037 -48.880 1.00 5.67  ? 149 GLY D O   1 
ATOM   7639 N  N   . SER D 1 150 ? 3.602   -14.711 -47.262 1.00 6.57  ? 150 SER D N   1 
ATOM   7640 C  CA  . SER D 1 150 ? 2.415   -14.806 -48.143 1.00 6.60  ? 150 SER D CA  1 
ATOM   7641 C  C   . SER D 1 150 ? 1.816   -13.446 -48.508 1.00 6.89  ? 150 SER D C   1 
ATOM   7642 O  O   . SER D 1 150 ? 1.889   -12.472 -47.707 1.00 7.72  ? 150 SER D O   1 
ATOM   7643 C  CB  . SER D 1 150 ? 1.332   -15.671 -47.495 1.00 6.84  ? 150 SER D CB  1 
ATOM   7644 O  OG  . SER D 1 150 ? 1.794   -16.991 -47.272 1.00 8.07  ? 150 SER D OG  1 
ATOM   7645 N  N   . PHE D 1 151 ? 1.232   -13.444 -49.697 1.00 6.89  ? 151 PHE D N   1 
ATOM   7646 C  CA  . PHE D 1 151 ? 0.424   -12.267 -50.108 1.00 7.40  ? 151 PHE D CA  1 
ATOM   7647 C  C   . PHE D 1 151 ? -0.584  -11.916 -49.061 1.00 7.43  ? 151 PHE D C   1 
ATOM   7648 O  O   . PHE D 1 151 ? -1.291  -12.793 -48.491 1.00 8.07  ? 151 PHE D O   1 
ATOM   7649 C  CB  . PHE D 1 151 ? -0.189  -12.532 -51.470 1.00 7.39  ? 151 PHE D CB  1 
ATOM   7650 C  CG  . PHE D 1 151 ? -1.059  -11.419 -51.963 1.00 7.16  ? 151 PHE D CG  1 
ATOM   7651 C  CD1 . PHE D 1 151 ? -0.453  -10.359 -52.560 1.00 7.94  ? 151 PHE D CD1 1 
ATOM   7652 C  CD2 . PHE D 1 151 ? -2.445  -11.459 -51.759 1.00 9.15  ? 151 PHE D CD2 1 
ATOM   7653 C  CE1 . PHE D 1 151 ? -1.269  -9.273  -52.994 1.00 7.91  ? 151 PHE D CE1 1 
ATOM   7654 C  CE2 . PHE D 1 151 ? -3.242  -10.403 -52.175 1.00 8.77  ? 151 PHE D CE2 1 
ATOM   7655 C  CZ  . PHE D 1 151 ? -2.620  -9.356  -52.827 1.00 8.35  ? 151 PHE D CZ  1 
ATOM   7656 N  N   . ASN D 1 152 ? -0.682  -10.593 -48.806 1.00 6.50  ? 152 ASN D N   1 
ATOM   7657 C  CA  . ASN D 1 152 ? -1.565  -10.156 -47.772 1.00 7.08  ? 152 ASN D CA  1 
ATOM   7658 C  C   . ASN D 1 152 ? -2.648  -9.233  -48.408 1.00 7.71  ? 152 ASN D C   1 
ATOM   7659 O  O   . ASN D 1 152 ? -2.357  -8.052  -48.788 1.00 7.19  ? 152 ASN D O   1 
ATOM   7660 C  CB  . ASN D 1 152 ? -0.766  -9.327  -46.721 1.00 5.90  ? 152 ASN D CB  1 
ATOM   7661 C  CG  . ASN D 1 152 ? -1.555  -9.063  -45.448 1.00 6.32  ? 152 ASN D CG  1 
ATOM   7662 O  OD1 . ASN D 1 152 ? -2.712  -8.551  -45.582 1.00 7.30  ? 152 ASN D OD1 1 
ATOM   7663 N  ND2 . ASN D 1 152 ? -1.034  -9.311  -44.285 1.00 6.71  ? 152 ASN D ND2 1 
ATOM   7664 N  N   . PRO D 1 153 ? -3.852  -9.714  -48.561 1.00 8.16  ? 153 PRO D N   1 
ATOM   7665 C  CA  . PRO D 1 153 ? -4.916  -8.918  -49.239 1.00 8.80  ? 153 PRO D CA  1 
ATOM   7666 C  C   . PRO D 1 153 ? -5.315  -7.653  -48.484 1.00 9.08  ? 153 PRO D C   1 
ATOM   7667 O  O   . PRO D 1 153 ? -5.675  -6.670  -49.136 1.00 10.92 ? 153 PRO D O   1 
ATOM   7668 C  CB  . PRO D 1 153 ? -6.091  -9.942  -49.313 1.00 10.82 ? 153 PRO D CB  1 
ATOM   7669 C  CG  . PRO D 1 153 ? -5.484  -11.273 -49.151 1.00 13.38 ? 153 PRO D CG  1 
ATOM   7670 C  CD  . PRO D 1 153 ? -4.296  -11.087 -48.203 1.00 9.51  ? 153 PRO D CD  1 
ATOM   7671 N  N   . SER D 1 154 ? -5.126  -7.665  -47.175 1.00 8.79  ? 154 SER D N   1 
ATOM   7672 C  CA  . SER D 1 154 ? -5.521  -6.453  -46.395 1.00 9.01  ? 154 SER D CA  1 
ATOM   7673 C  C   . SER D 1 154 ? -4.498  -5.354  -46.606 1.00 9.21  ? 154 SER D C   1 
ATOM   7674 O  O   . SER D 1 154 ? -4.880  -4.199  -46.845 1.00 9.13  ? 154 SER D O   1 
ATOM   7675 C  CB  . SER D 1 154 ? -5.659  -6.760  -44.942 1.00 10.81 ? 154 SER D CB  1 
ATOM   7676 O  OG  . SER D 1 154 ? -6.657  -7.756  -44.753 1.00 14.17 ? 154 SER D OG  1 
ATOM   7677 N  N   . TYR D 1 155 ? -3.178  -5.641  -46.536 1.00 7.47  ? 155 TYR D N   1 
ATOM   7678 C  CA  . TYR D 1 155 ? -2.185  -4.613  -46.856 1.00 7.45  ? 155 TYR D CA  1 
ATOM   7679 C  C   . TYR D 1 155 ? -2.351  -4.212  -48.286 1.00 7.17  ? 155 TYR D C   1 
ATOM   7680 O  O   . TYR D 1 155 ? -2.064  -3.022  -48.637 1.00 8.16  ? 155 TYR D O   1 
ATOM   7681 C  CB  . TYR D 1 155 ? -0.754  -5.097  -46.556 1.00 6.61  ? 155 TYR D CB  1 
ATOM   7682 C  CG  . TYR D 1 155 ? -0.416  -4.973  -45.068 1.00 5.69  ? 155 TYR D CG  1 
ATOM   7683 C  CD1 . TYR D 1 155 ? 0.351   -3.917  -44.627 1.00 6.12  ? 155 TYR D CD1 1 
ATOM   7684 C  CD2 . TYR D 1 155 ? -0.881  -5.890  -44.131 1.00 5.54  ? 155 TYR D CD2 1 
ATOM   7685 C  CE1 . TYR D 1 155 ? 0.654   -3.766  -43.292 1.00 6.98  ? 155 TYR D CE1 1 
ATOM   7686 C  CE2 . TYR D 1 155 ? -0.580  -5.753  -42.789 1.00 6.11  ? 155 TYR D CE2 1 
ATOM   7687 C  CZ  . TYR D 1 155 ? 0.194   -4.687  -42.369 1.00 6.72  ? 155 TYR D CZ  1 
ATOM   7688 O  OH  . TYR D 1 155 ? 0.502   -4.535  -41.031 1.00 7.02  ? 155 TYR D OH  1 
ATOM   7689 N  N   . ASP D 1 156 ? -2.789  -5.073  -49.212 1.00 7.88  ? 156 ASP D N   1 
ATOM   7690 C  CA  . ASP D 1 156 ? -2.916  -4.646  -50.565 1.00 7.89  ? 156 ASP D CA  1 
ATOM   7691 C  C   . ASP D 1 156 ? -4.061  -3.601  -50.774 1.00 7.40  ? 156 ASP D C   1 
ATOM   7692 O  O   . ASP D 1 156 ? -4.009  -2.974  -51.836 1.00 8.74  ? 156 ASP D O   1 
ATOM   7693 C  CB  . ASP D 1 156 ? -3.109  -5.838  -51.511 1.00 10.16 ? 156 ASP D CB  1 
ATOM   7694 C  CG  . ASP D 1 156 ? -2.255  -5.730  -52.763 1.00 10.81 ? 156 ASP D CG  1 
ATOM   7695 O  OD1 . ASP D 1 156 ? -1.022  -5.572  -52.631 1.00 10.74 ? 156 ASP D OD1 1 
ATOM   7696 O  OD2 . ASP D 1 156 ? -2.814  -5.799  -53.877 1.00 15.83 ? 156 ASP D OD2 1 
ATOM   7697 N  N   . LYS D 1 157 ? -4.980  -3.484  -49.784 1.00 8.37  ? 157 LYS D N   1 
ATOM   7698 C  CA  . LYS D 1 157 ? -6.025  -2.425  -49.925 1.00 9.70  ? 157 LYS D CA  1 
ATOM   7699 C  C   . LYS D 1 157 ? -5.248  -1.091  -49.859 1.00 11.13 ? 157 LYS D C   1 
ATOM   7700 O  O   . LYS D 1 157 ? -5.731  -0.114  -50.504 1.00 12.73 ? 157 LYS D O   1 
ATOM   7701 C  CB  . LYS D 1 157 ? -7.003  -2.538  -48.834 1.00 11.03 ? 157 LYS D CB  1 
ATOM   7702 C  CG  . LYS D 1 157 ? -7.864  -3.801  -48.953 1.00 12.67 ? 157 LYS D CG  1 
ATOM   7703 C  CD  . LYS D 1 157 ? -8.708  -4.140  -47.719 1.00 16.68 ? 157 LYS D CD  1 
ATOM   7704 C  CE  . LYS D 1 157 ? -9.440  -5.523  -47.816 1.00 18.61 ? 157 LYS D CE  1 
ATOM   7705 N  NZ  . LYS D 1 157 ? -10.330 -5.950  -46.652 1.00 21.54 ? 157 LYS D NZ  1 
ATOM   7706 N  N   . ILE D 1 158 ? -4.088  -0.975  -49.231 1.00 9.17  ? 158 ILE D N   1 
ATOM   7707 C  CA  . ILE D 1 158 ? -3.313  0.242   -49.325 1.00 9.69  ? 158 ILE D CA  1 
ATOM   7708 C  C   . ILE D 1 158 ? -2.400  0.226   -50.504 1.00 8.43  ? 158 ILE D C   1 
ATOM   7709 O  O   . ILE D 1 158 ? -2.303  1.180   -51.301 1.00 9.18  ? 158 ILE D O   1 
ATOM   7710 C  CB  . ILE D 1 158 ? -2.444  0.408   -48.059 1.00 10.54 ? 158 ILE D CB  1 
ATOM   7711 C  CG1 . ILE D 1 158 ? -3.394  0.619   -46.826 1.00 12.46 ? 158 ILE D CG1 1 
ATOM   7712 C  CG2 . ILE D 1 158 ? -1.430  1.572   -48.229 1.00 10.92 ? 158 ILE D CG2 1 
ATOM   7713 C  CD1 . ILE D 1 158 ? -2.676  0.363   -45.496 1.00 14.39 ? 158 ILE D CD1 1 
ATOM   7714 N  N   . PHE D 1 159 ? -1.675  -0.910  -50.712 1.00 8.21  ? 159 PHE D N   1 
ATOM   7715 C  CA  . PHE D 1 159 ? -0.613  -0.884  -51.679 1.00 9.37  ? 159 PHE D CA  1 
ATOM   7716 C  C   . PHE D 1 159 ? -1.095  -0.750  -53.135 1.00 9.43  ? 159 PHE D C   1 
ATOM   7717 O  O   . PHE D 1 159 ? -0.366  -0.255  -53.938 1.00 10.58 ? 159 PHE D O   1 
ATOM   7718 C  CB  . PHE D 1 159 ? 0.195   -2.220  -51.596 1.00 8.19  ? 159 PHE D CB  1 
ATOM   7719 C  CG  . PHE D 1 159 ? 0.953   -2.447  -50.294 1.00 9.31  ? 159 PHE D CG  1 
ATOM   7720 C  CD1 . PHE D 1 159 ? 1.294   -1.413  -49.415 1.00 10.74 ? 159 PHE D CD1 1 
ATOM   7721 C  CD2 . PHE D 1 159 ? 1.288   -3.739  -49.958 1.00 9.90  ? 159 PHE D CD2 1 
ATOM   7722 C  CE1 . PHE D 1 159 ? 1.964   -1.737  -48.219 1.00 11.33 ? 159 PHE D CE1 1 
ATOM   7723 C  CE2 . PHE D 1 159 ? 1.999   -4.008  -48.831 1.00 10.47 ? 159 PHE D CE2 1 
ATOM   7724 C  CZ  . PHE D 1 159 ? 2.385   -2.997  -47.976 1.00 10.48 ? 159 PHE D CZ  1 
ATOM   7725 N  N   . SER D 1 160 ? -2.314  -1.181  -53.399 1.00 10.23 ? 160 SER D N   1 
ATOM   7726 C  CA  . SER D 1 160 ? -2.864  -1.009  -54.745 1.00 10.63 ? 160 SER D CA  1 
ATOM   7727 C  C   . SER D 1 160 ? -3.005  0.410   -55.221 1.00 11.62 ? 160 SER D C   1 
ATOM   7728 O  O   . SER D 1 160 ? -3.109  0.683   -56.405 1.00 13.02 ? 160 SER D O   1 
ATOM   7729 C  CB  . SER D 1 160 ? -4.207  -1.752  -54.864 1.00 12.75 ? 160 SER D CB  1 
ATOM   7730 O  OG  . SER D 1 160 ? -5.210  -1.091  -54.149 1.00 13.72 ? 160 SER D OG  1 
ATOM   7731 N  N   . HIS D 1 161 ? -2.907  1.367   -54.331 1.00 10.12 ? 161 HIS D N   1 
ATOM   7732 C  CA  . HIS D 1 161 ? -3.026  2.797   -54.646 1.00 10.82 ? 161 HIS D CA  1 
ATOM   7733 C  C   . HIS D 1 161 ? -1.689  3.512   -54.715 1.00 12.07 ? 161 HIS D C   1 
ATOM   7734 O  O   . HIS D 1 161 ? -1.694  4.677   -55.052 1.00 12.41 ? 161 HIS D O   1 
ATOM   7735 C  CB  . HIS D 1 161 ? -3.884  3.497   -53.551 1.00 10.17 ? 161 HIS D CB  1 
ATOM   7736 C  CG  . HIS D 1 161 ? -5.269  3.005   -53.479 1.00 11.31 ? 161 HIS D CG  1 
ATOM   7737 N  ND1 . HIS D 1 161 ? -6.284  3.578   -54.232 1.00 13.68 ? 161 HIS D ND1 1 
ATOM   7738 C  CD2 . HIS D 1 161 ? -5.843  1.976   -52.755 1.00 11.84 ? 161 HIS D CD2 1 
ATOM   7739 C  CE1 . HIS D 1 161 ? -7.431  2.923   -53.965 1.00 14.27 ? 161 HIS D CE1 1 
ATOM   7740 N  NE2 . HIS D 1 161 ? -7.168  1.919   -53.093 1.00 13.35 ? 161 HIS D NE2 1 
ATOM   7741 N  N   . LEU D 1 162 ? -0.579  2.814   -54.510 1.00 13.84 ? 162 LEU D N   1 
ATOM   7742 C  CA  . LEU D 1 162 ? 0.722   3.544   -54.380 1.00 15.03 ? 162 LEU D CA  1 
ATOM   7743 C  C   . LEU D 1 162 ? 1.089   4.197   -55.687 1.00 14.64 ? 162 LEU D C   1 
ATOM   7744 O  O   . LEU D 1 162 ? 1.760   5.284   -55.657 1.00 17.48 ? 162 LEU D O   1 
ATOM   7745 C  CB  . LEU D 1 162 ? 1.821   2.507   -54.041 1.00 17.81 ? 162 LEU D CB  1 
ATOM   7746 C  CG  . LEU D 1 162 ? 1.665   1.998   -52.613 1.00 21.12 ? 162 LEU D CG  1 
ATOM   7747 C  CD1 . LEU D 1 162 ? 2.795   0.981   -52.385 1.00 22.56 ? 162 LEU D CD1 1 
ATOM   7748 C  CD2 . LEU D 1 162 ? 1.614   3.056   -51.516 1.00 22.18 ? 162 LEU D CD2 1 
ATOM   7749 N  N   . GLN D 1 163 ? 0.693   3.616   -56.814 1.00 17.37 ? 163 GLN D N   1 
ATOM   7750 C  CA  . GLN D 1 163 ? 1.048   4.260   -58.095 1.00 18.78 ? 163 GLN D CA  1 
ATOM   7751 C  C   . GLN D 1 163 ? 0.392   5.642   -58.297 1.00 20.32 ? 163 GLN D C   1 
ATOM   7752 O  O   . GLN D 1 163 ? 0.807   6.416   -59.113 1.00 24.96 ? 163 GLN D O   1 
ATOM   7753 C  CB  . GLN D 1 163 ? 0.867   3.341   -59.298 1.00 24.72 ? 163 GLN D CB  1 
ATOM   7754 C  CG  . GLN D 1 163 ? 1.755   2.062   -59.204 1.00 31.99 ? 163 GLN D CG  1 
ATOM   7755 C  CD  . GLN D 1 163 ? 3.307   2.230   -59.273 1.00 32.85 ? 163 GLN D CD  1 
ATOM   7756 O  OE1 . GLN D 1 163 ? 3.865   3.114   -59.942 1.00 41.93 ? 163 GLN D OE1 1 
ATOM   7757 N  NE2 . GLN D 1 163 ? 3.997   1.321   -58.619 1.00 29.67 ? 163 GLN D NE2 1 
ATOM   7758 N  N   . HIS D 1 164 ? -0.602  5.968   -57.506 1.00 15.02 ? 164 HIS D N   1 
ATOM   7759 C  CA  . HIS D 1 164 ? -1.238  7.279   -57.576 1.00 14.71 ? 164 HIS D CA  1 
ATOM   7760 C  C   . HIS D 1 164 ? -0.747  8.336   -56.631 1.00 16.21 ? 164 HIS D C   1 
ATOM   7761 O  O   . HIS D 1 164 ? -1.240  9.531   -56.596 1.00 15.14 ? 164 HIS D O   1 
ATOM   7762 C  CB  . HIS D 1 164 ? -2.716  7.087   -57.350 1.00 18.42 ? 164 HIS D CB  1 
ATOM   7763 C  CG  . HIS D 1 164 ? -3.324  6.199   -58.407 1.00 21.86 ? 164 HIS D CG  1 
ATOM   7764 N  ND1 . HIS D 1 164 ? -3.542  6.633   -59.637 1.00 26.73 ? 164 HIS D ND1 1 
ATOM   7765 C  CD2 . HIS D 1 164 ? -3.701  4.861   -58.384 1.00 29.36 ? 164 HIS D CD2 1 
ATOM   7766 C  CE1 . HIS D 1 164 ? -4.056  5.633   -60.389 1.00 31.77 ? 164 HIS D CE1 1 
ATOM   7767 N  NE2 . HIS D 1 164 ? -4.152  4.551   -59.621 1.00 35.86 ? 164 HIS D NE2 1 
ATOM   7768 N  N   . VAL D 1 165 ? 0.228   7.928   -55.796 1.00 11.70 ? 165 VAL D N   1 
ATOM   7769 C  CA  . VAL D 1 165 ? 0.875   8.829   -54.871 1.00 12.22 ? 165 VAL D CA  1 
ATOM   7770 C  C   . VAL D 1 165 ? 2.393   8.731   -55.032 1.00 11.59 ? 165 VAL D C   1 
ATOM   7771 O  O   . VAL D 1 165 ? 3.146   8.889   -54.057 1.00 10.55 ? 165 VAL D O   1 
ATOM   7772 C  CB  . VAL D 1 165 ? 0.377   8.595   -53.397 1.00 14.04 ? 165 VAL D CB  1 
ATOM   7773 C  CG1 . VAL D 1 165 ? -1.117  8.915   -53.244 1.00 16.89 ? 165 VAL D CG1 1 
ATOM   7774 C  CG2 . VAL D 1 165 ? 0.689   7.200   -52.877 1.00 14.40 ? 165 VAL D CG2 1 
ATOM   7775 N  N   A LYS D 1 166 ? 2.842   8.491   -56.243 0.50 10.83 ? 166 LYS D N   1 
ATOM   7776 N  N   B LYS D 1 166 ? 2.776   8.520   -56.264 0.50 10.78 ? 166 LYS D N   1 
ATOM   7777 C  CA  A LYS D 1 166 ? 4.277   8.311   -56.475 0.50 11.20 ? 166 LYS D CA  1 
ATOM   7778 C  CA  B LYS D 1 166 ? 4.155   8.332   -56.613 0.50 11.23 ? 166 LYS D CA  1 
ATOM   7779 C  C   A LYS D 1 166 ? 5.122   9.508   -56.011 0.50 10.19 ? 166 LYS D C   1 
ATOM   7780 C  C   B LYS D 1 166 ? 5.103   9.475   -56.187 0.50 10.22 ? 166 LYS D C   1 
ATOM   7781 O  O   A LYS D 1 166 ? 6.158   9.303   -55.399 0.50 9.04  ? 166 LYS D O   1 
ATOM   7782 O  O   B LYS D 1 166 ? 6.219   9.173   -55.788 0.50 9.61  ? 166 LYS D O   1 
ATOM   7783 C  CB  A LYS D 1 166 ? 4.558   7.963   -57.950 0.50 12.60 ? 166 LYS D CB  1 
ATOM   7784 C  CB  B LYS D 1 166 ? 4.284   8.102   -58.117 0.50 12.26 ? 166 LYS D CB  1 
ATOM   7785 C  CG  A LYS D 1 166 ? 3.881   6.672   -58.363 0.50 14.08 ? 166 LYS D CG  1 
ATOM   7786 C  CG  B LYS D 1 166 ? 5.738   7.895   -58.477 0.50 13.50 ? 166 LYS D CG  1 
ATOM   7787 C  CD  A LYS D 1 166 ? 4.320   6.247   -59.740 0.50 17.43 ? 166 LYS D CD  1 
ATOM   7788 C  CD  B LYS D 1 166 ? 5.905   7.605   -59.968 0.50 16.46 ? 166 LYS D CD  1 
ATOM   7789 C  CE  A LYS D 1 166 ? 5.846   5.998   -59.757 0.50 17.05 ? 166 LYS D CE  1 
ATOM   7790 C  CE  B LYS D 1 166 ? 5.004   6.516   -60.524 0.50 22.17 ? 166 LYS D CE  1 
ATOM   7791 N  NZ  A LYS D 1 166 ? 6.209   4.616   -59.294 0.50 21.35 ? 166 LYS D NZ  1 
ATOM   7792 N  NZ  B LYS D 1 166 ? 5.390   5.120   -60.163 0.50 25.06 ? 166 LYS D NZ  1 
ATOM   7793 N  N   . TYR D 1 167 ? 4.665   10.746  -56.223 1.00 10.75 ? 167 TYR D N   1 
ATOM   7794 C  CA  . TYR D 1 167 ? 5.502   11.886  -55.974 1.00 9.74  ? 167 TYR D CA  1 
ATOM   7795 C  C   . TYR D 1 167 ? 5.048   12.749  -54.866 1.00 8.57  ? 167 TYR D C   1 
ATOM   7796 O  O   . TYR D 1 167 ? 3.841   12.725  -54.518 1.00 8.39  ? 167 TYR D O   1 
ATOM   7797 C  CB  . TYR D 1 167 ? 5.571   12.715  -57.300 1.00 10.80 ? 167 TYR D CB  1 
ATOM   7798 C  CG  . TYR D 1 167 ? 6.303   12.024  -58.379 1.00 12.18 ? 167 TYR D CG  1 
ATOM   7799 C  CD1 . TYR D 1 167 ? 7.693   11.919  -58.350 1.00 13.33 ? 167 TYR D CD1 1 
ATOM   7800 C  CD2 . TYR D 1 167 ? 5.610   11.464  -59.432 1.00 15.01 ? 167 TYR D CD2 1 
ATOM   7801 C  CE1 . TYR D 1 167 ? 8.372   11.266  -59.356 1.00 14.55 ? 167 TYR D CE1 1 
ATOM   7802 C  CE2 . TYR D 1 167 ? 6.277   10.812  -60.437 1.00 16.17 ? 167 TYR D CE2 1 
ATOM   7803 C  CZ  . TYR D 1 167 ? 7.654   10.715  -60.391 1.00 16.98 ? 167 TYR D CZ  1 
ATOM   7804 O  OH  . TYR D 1 167 ? 8.326   10.073  -61.390 1.00 24.07 ? 167 TYR D OH  1 
ATOM   7805 N  N   . LYS D 1 168 ? 5.980   13.489  -54.262 1.00 9.66  ? 168 LYS D N   1 
ATOM   7806 C  CA  . LYS D 1 168 ? 5.620   14.409  -53.189 1.00 11.02 ? 168 LYS D CA  1 
ATOM   7807 C  C   . LYS D 1 168 ? 4.433   15.243  -53.569 1.00 12.77 ? 168 LYS D C   1 
ATOM   7808 O  O   . LYS D 1 168 ? 4.359   15.817  -54.637 1.00 13.38 ? 168 LYS D O   1 
ATOM   7809 C  CB  . LYS D 1 168 ? 6.829   15.272  -52.848 1.00 12.15 ? 168 LYS D CB  1 
ATOM   7810 C  CG  . LYS D 1 168 ? 6.481   16.185  -51.693 1.00 14.92 ? 168 LYS D CG  1 
ATOM   7811 C  CD  . LYS D 1 168 ? 7.757   16.854  -51.189 1.00 20.25 ? 168 LYS D CD  1 
ATOM   7812 C  CE  . LYS D 1 168 ? 7.292   18.064  -50.412 1.00 22.45 ? 168 LYS D CE  1 
ATOM   7813 N  NZ  . LYS D 1 168 ? 8.483   18.968  -50.210 1.00 29.04 ? 168 LYS D NZ  1 
ATOM   7814 N  N   . GLY D 1 169 ? 3.473   15.332  -52.631 1.00 12.85 ? 169 GLY D N   1 
ATOM   7815 C  CA  . GLY D 1 169 ? 2.271   16.107  -52.742 1.00 14.52 ? 169 GLY D CA  1 
ATOM   7816 C  C   . GLY D 1 169 ? 1.064   15.480  -53.432 1.00 15.97 ? 169 GLY D C   1 
ATOM   7817 O  O   . GLY D 1 169 ? -0.051  16.059  -53.397 1.00 17.28 ? 169 GLY D O   1 
ATOM   7818 N  N   . GLN D 1 170 ? 1.268   14.301  -54.022 1.00 10.91 ? 170 GLN D N   1 
ATOM   7819 C  CA  . GLN D 1 170 ? 0.206   13.561  -54.674 1.00 11.19 ? 170 GLN D CA  1 
ATOM   7820 C  C   . GLN D 1 170 ? -0.649  12.836  -53.616 1.00 12.83 ? 170 GLN D C   1 
ATOM   7821 O  O   . GLN D 1 170 ? -0.144  12.369  -52.536 1.00 13.28 ? 170 GLN D O   1 
ATOM   7822 C  CB  . GLN D 1 170 ? 0.803   12.587  -55.691 1.00 11.46 ? 170 GLN D CB  1 
ATOM   7823 C  CG  . GLN D 1 170 ? 1.431   13.343  -56.863 1.00 10.91 ? 170 GLN D CG  1 
ATOM   7824 C  CD  . GLN D 1 170 ? 1.876   12.480  -57.954 1.00 14.37 ? 170 GLN D CD  1 
ATOM   7825 O  OE1 . GLN D 1 170 ? 2.153   11.299  -57.801 1.00 14.10 ? 170 GLN D OE1 1 
ATOM   7826 N  NE2 . GLN D 1 170 ? 1.799   13.036  -59.167 1.00 19.28 ? 170 GLN D NE2 1 
ATOM   7827 N  N   . GLU D 1 171 ? -1.920  12.629  -53.945 1.00 14.37 ? 171 GLU D N   1 
ATOM   7828 C  CA  . GLU D 1 171 ? -2.903  12.143  -52.972 1.00 13.48 ? 171 GLU D CA  1 
ATOM   7829 C  C   . GLU D 1 171 ? -3.847  11.251  -53.750 1.00 14.32 ? 171 GLU D C   1 
ATOM   7830 O  O   . GLU D 1 171 ? -4.096  11.490  -54.970 1.00 15.65 ? 171 GLU D O   1 
ATOM   7831 C  CB  . GLU D 1 171 ? -3.717  13.283  -52.387 1.00 17.35 ? 171 GLU D CB  1 
ATOM   7832 C  CG  . GLU D 1 171 ? -2.964  14.352  -51.591 1.00 21.02 ? 171 GLU D CG  1 
ATOM   7833 C  CD  . GLU D 1 171 ? -3.863  15.522  -51.170 1.00 29.94 ? 171 GLU D CD  1 
ATOM   7834 O  OE1 . GLU D 1 171 ? -4.934  15.690  -51.803 1.00 35.39 ? 171 GLU D OE1 1 
ATOM   7835 O  OE2 . GLU D 1 171 ? -3.488  16.272  -50.223 1.00 38.17 ? 171 GLU D OE2 1 
ATOM   7836 N  N   . ALA D 1 172 ? -4.456  10.279  -53.079 1.00 12.20 ? 172 ALA D N   1 
ATOM   7837 C  CA  . ALA D 1 172 ? -5.386  9.332   -53.681 1.00 11.78 ? 172 ALA D CA  1 
ATOM   7838 C  C   . ALA D 1 172 ? -6.334  8.948   -52.563 1.00 12.49 ? 172 ALA D C   1 
ATOM   7839 O  O   . ALA D 1 172 ? -5.973  8.924   -51.375 1.00 14.76 ? 172 ALA D O   1 
ATOM   7840 C  CB  . ALA D 1 172 ? -4.683  8.138   -54.212 1.00 12.09 ? 172 ALA D CB  1 
ATOM   7841 N  N   . PHE D 1 173 ? -7.557  8.587   -52.909 1.00 11.92 ? 173 PHE D N   1 
ATOM   7842 C  CA  . PHE D 1 173 ? -8.498  8.085   -51.909 1.00 10.92 ? 173 PHE D CA  1 
ATOM   7843 C  C   . PHE D 1 173 ? -8.518  6.588   -51.868 1.00 12.09 ? 173 PHE D C   1 
ATOM   7844 O  O   . PHE D 1 173 ? -8.497  5.914   -52.879 1.00 14.07 ? 173 PHE D O   1 
ATOM   7845 C  CB  . PHE D 1 173 ? -9.922  8.608   -52.259 1.00 14.42 ? 173 PHE D CB  1 
ATOM   7846 C  CG  . PHE D 1 173 ? -10.175 10.008  -51.737 1.00 15.64 ? 173 PHE D CG  1 
ATOM   7847 C  CD1 . PHE D 1 173 ? -10.180 10.288  -50.343 1.00 17.02 ? 173 PHE D CD1 1 
ATOM   7848 C  CD2 . PHE D 1 173 ? -10.396 11.049  -52.594 1.00 22.58 ? 173 PHE D CD2 1 
ATOM   7849 C  CE1 . PHE D 1 173 ? -10.380 11.575  -49.827 1.00 22.17 ? 173 PHE D CE1 1 
ATOM   7850 C  CE2 . PHE D 1 173 ? -10.601 12.347  -52.090 1.00 22.14 ? 173 PHE D CE2 1 
ATOM   7851 C  CZ  . PHE D 1 173 ? -10.583 12.619  -50.728 1.00 22.50 ? 173 PHE D CZ  1 
ATOM   7852 N  N   . VAL D 1 174 ? -8.531  6.076   -50.643 1.00 10.83 ? 174 VAL D N   1 
ATOM   7853 C  CA  . VAL D 1 174 ? -8.576  4.644   -50.353 1.00 10.02 ? 174 VAL D CA  1 
ATOM   7854 C  C   . VAL D 1 174 ? -9.937  4.374   -49.685 1.00 10.35 ? 174 VAL D C   1 
ATOM   7855 O  O   . VAL D 1 174 ? -10.261 4.947   -48.633 1.00 9.96  ? 174 VAL D O   1 
ATOM   7856 C  CB  . VAL D 1 174 ? -7.466  4.271   -49.365 1.00 9.49  ? 174 VAL D CB  1 
ATOM   7857 C  CG1 . VAL D 1 174 ? -7.569  2.768   -48.975 1.00 10.49 ? 174 VAL D CG1 1 
ATOM   7858 C  CG2 . VAL D 1 174 ? -6.126  4.609   -50.141 1.00 12.08 ? 174 VAL D CG2 1 
ATOM   7859 N  N   . PRO D 1 175 ? -10.761 3.416   -50.218 1.00 9.41  ? 175 PRO D N   1 
ATOM   7860 C  CA  . PRO D 1 175 ? -12.014 3.083   -49.568 1.00 9.62  ? 175 PRO D CA  1 
ATOM   7861 C  C   . PRO D 1 175 ? -11.699 2.456   -48.189 1.00 9.22  ? 175 PRO D C   1 
ATOM   7862 O  O   . PRO D 1 175 ? -10.655 1.803   -47.958 1.00 10.03 ? 175 PRO D O   1 
ATOM   7863 C  CB  . PRO D 1 175 ? -12.621 1.985   -50.440 1.00 10.43 ? 175 PRO D CB  1 
ATOM   7864 C  CG  . PRO D 1 175 ? -11.963 2.124   -51.771 1.00 12.44 ? 175 PRO D CG  1 
ATOM   7865 C  CD  . PRO D 1 175 ? -10.543 2.671   -51.459 1.00 10.80 ? 175 PRO D CD  1 
ATOM   7866 N  N   . GLY D 1 176 ? -12.577 2.674   -47.202 1.00 8.76  ? 176 GLY D N   1 
ATOM   7867 C  CA  . GLY D 1 176 ? -12.402 2.141   -45.887 1.00 7.94  ? 176 GLY D CA  1 
ATOM   7868 C  C   . GLY D 1 176 ? -12.381 0.594   -45.883 1.00 7.80  ? 176 GLY D C   1 
ATOM   7869 O  O   . GLY D 1 176 ? -13.037 -0.050  -46.672 1.00 9.83  ? 176 GLY D O   1 
ATOM   7870 N  N   . PHE D 1 177 ? -11.643 0.125   -44.899 1.00 8.53  ? 177 PHE D N   1 
ATOM   7871 C  CA  . PHE D 1 177 ? -11.628 -1.289  -44.621 1.00 8.10  ? 177 PHE D CA  1 
ATOM   7872 C  C   . PHE D 1 177 ? -11.297 -1.370  -43.142 1.00 9.05  ? 177 PHE D C   1 
ATOM   7873 O  O   . PHE D 1 177 ? -11.085 -0.406  -42.401 1.00 9.84  ? 177 PHE D O   1 
ATOM   7874 C  CB  . PHE D 1 177 ? -10.630 -2.029  -45.505 1.00 8.85  ? 177 PHE D CB  1 
ATOM   7875 C  CG  . PHE D 1 177 ? -9.205  -1.665  -45.288 1.00 9.66  ? 177 PHE D CG  1 
ATOM   7876 C  CD1 . PHE D 1 177 ? -8.408  -2.456  -44.410 1.00 11.04 ? 177 PHE D CD1 1 
ATOM   7877 C  CD2 . PHE D 1 177 ? -8.637  -0.563  -45.950 1.00 9.77  ? 177 PHE D CD2 1 
ATOM   7878 C  CE1 . PHE D 1 177 ? -7.040  -2.145  -44.295 1.00 9.82  ? 177 PHE D CE1 1 
ATOM   7879 C  CE2 . PHE D 1 177 ? -7.302  -0.186  -45.723 1.00 10.70 ? 177 PHE D CE2 1 
ATOM   7880 C  CZ  . PHE D 1 177 ? -6.510  -1.011  -44.918 1.00 11.75 ? 177 PHE D CZ  1 
ATOM   7881 N  N   . ASN D 1 178 ? -11.379 -2.614  -42.654 1.00 9.73  ? 178 ASN D N   1 
ATOM   7882 C  CA  . ASN D 1 178 ? -11.122 -2.838  -41.249 1.00 9.56  ? 178 ASN D CA  1 
ATOM   7883 C  C   . ASN D 1 178 ? -9.608  -2.834  -41.003 1.00 10.02 ? 178 ASN D C   1 
ATOM   7884 O  O   . ASN D 1 178 ? -8.909  -3.823  -41.304 1.00 9.97  ? 178 ASN D O   1 
ATOM   7885 C  CB  . ASN D 1 178 ? -11.726 -4.225  -40.799 1.00 11.68 ? 178 ASN D CB  1 
ATOM   7886 C  CG  . ASN D 1 178 ? -11.560 -4.477  -39.356 1.00 11.73 ? 178 ASN D CG  1 
ATOM   7887 O  OD1 . ASN D 1 178 ? -11.174 -3.684  -38.567 1.00 11.22 ? 178 ASN D OD1 1 
ATOM   7888 N  ND2 . ASN D 1 178 ? -11.903 -5.745  -38.962 1.00 17.02 ? 178 ASN D ND2 1 
ATOM   7889 N  N   . ILE D 1 179 ? -9.135  -1.831  -40.325 1.00 8.68  ? 179 ILE D N   1 
ATOM   7890 C  CA  . ILE D 1 179 ? -7.718  -1.603  -40.062 1.00 8.38  ? 179 ILE D CA  1 
ATOM   7891 C  C   . ILE D 1 179 ? -7.190  -2.640  -39.077 1.00 8.56  ? 179 ILE D C   1 
ATOM   7892 O  O   . ILE D 1 179 ? -5.996  -2.899  -39.074 1.00 8.81  ? 179 ILE D O   1 
ATOM   7893 C  CB  . ILE D 1 179 ? -7.536  -0.162  -39.509 1.00 8.62  ? 179 ILE D CB  1 
ATOM   7894 C  CG1 . ILE D 1 179 ? -8.041  0.907   -40.477 1.00 9.08  ? 179 ILE D CG1 1 
ATOM   7895 C  CG2 . ILE D 1 179 ? -6.053  0.157   -39.206 1.00 9.94  ? 179 ILE D CG2 1 
ATOM   7896 C  CD1 . ILE D 1 179 ? -7.398  0.902   -41.899 1.00 10.89 ? 179 ILE D CD1 1 
ATOM   7897 N  N   . GLU D 1 180 ? -8.059  -3.298  -38.308 1.00 8.75  ? 180 GLU D N   1 
ATOM   7898 C  CA  . GLU D 1 180 ? -7.589  -4.380  -37.462 1.00 9.52  ? 180 GLU D CA  1 
ATOM   7899 C  C   . GLU D 1 180 ? -7.034  -5.535  -38.348 1.00 9.21  ? 180 GLU D C   1 
ATOM   7900 O  O   . GLU D 1 180 ? -6.239  -6.324  -37.814 1.00 11.57 ? 180 GLU D O   1 
ATOM   7901 C  CB  . GLU D 1 180 ? -8.756  -4.892  -36.611 1.00 12.86 ? 180 GLU D CB  1 
ATOM   7902 C  CG  . GLU D 1 180 ? -8.993  -4.251  -35.276 1.00 19.12 ? 180 GLU D CG  1 
ATOM   7903 C  CD  . GLU D 1 180 ? -9.668  -5.188  -34.266 1.00 20.76 ? 180 GLU D CD  1 
ATOM   7904 O  OE1 . GLU D 1 180 ? -10.898 -5.155  -34.166 1.00 27.64 ? 180 GLU D OE1 1 
ATOM   7905 O  OE2 . GLU D 1 180 ? -8.968  -5.961  -33.596 1.00 24.83 ? 180 GLU D OE2 1 
ATOM   7906 N  N   . GLU D 1 181 ? -7.434  -5.624  -39.594 1.00 9.04  ? 181 GLU D N   1 
ATOM   7907 C  CA  . GLU D 1 181 ? -6.887  -6.668  -40.469 1.00 9.29  ? 181 GLU D CA  1 
ATOM   7908 C  C   . GLU D 1 181 ? -5.425  -6.463  -40.749 1.00 8.83  ? 181 GLU D C   1 
ATOM   7909 O  O   . GLU D 1 181 ? -4.756  -7.403  -41.217 1.00 9.61  ? 181 GLU D O   1 
ATOM   7910 C  CB  . GLU D 1 181 ? -7.576  -6.672  -41.833 1.00 11.09 ? 181 GLU D CB  1 
ATOM   7911 C  CG  . GLU D 1 181 ? -9.036  -7.117  -41.813 1.00 11.93 ? 181 GLU D CG  1 
ATOM   7912 C  CD  . GLU D 1 181 ? -9.693  -6.882  -43.164 1.00 18.10 ? 181 GLU D CD  1 
ATOM   7913 O  OE1 . GLU D 1 181 ? -9.023  -6.471  -44.183 1.00 21.55 ? 181 GLU D OE1 1 
ATOM   7914 O  OE2 . GLU D 1 181 ? -10.950 -7.056  -43.204 1.00 18.90 ? 181 GLU D OE2 1 
ATOM   7915 N  N   . LEU D 1 182 ? -4.859  -5.286  -40.428 1.00 7.45  ? 182 LEU D N   1 
ATOM   7916 C  CA  . LEU D 1 182 ? -3.420  -5.097  -40.551 1.00 7.16  ? 182 LEU D CA  1 
ATOM   7917 C  C   . LEU D 1 182 ? -2.647  -5.519  -39.331 1.00 7.79  ? 182 LEU D C   1 
ATOM   7918 O  O   . LEU D 1 182 ? -1.375  -5.519  -39.392 1.00 7.44  ? 182 LEU D O   1 
ATOM   7919 C  CB  . LEU D 1 182 ? -3.165  -3.573  -40.760 1.00 6.81  ? 182 LEU D CB  1 
ATOM   7920 C  CG  . LEU D 1 182 ? -3.857  -2.927  -41.985 1.00 6.53  ? 182 LEU D CG  1 
ATOM   7921 C  CD1 . LEU D 1 182 ? -3.461  -1.429  -42.012 1.00 7.27  ? 182 LEU D CD1 1 
ATOM   7922 C  CD2 . LEU D 1 182 ? -3.549  -3.618  -43.280 1.00 6.77  ? 182 LEU D CD2 1 
ATOM   7923 N  N   . LEU D 1 183 ? -3.299  -5.811  -38.237 1.00 7.99  ? 183 LEU D N   1 
ATOM   7924 C  CA  . LEU D 1 183 ? -2.650  -6.200  -37.019 1.00 8.25  ? 183 LEU D CA  1 
ATOM   7925 C  C   . LEU D 1 183 ? -2.376  -7.701  -37.021 1.00 7.80  ? 183 LEU D C   1 
ATOM   7926 O  O   . LEU D 1 183 ? -3.058  -8.493  -37.722 1.00 9.11  ? 183 LEU D O   1 
ATOM   7927 C  CB  . LEU D 1 183 ? -3.554  -5.873  -35.802 1.00 9.35  ? 183 LEU D CB  1 
ATOM   7928 C  CG  . LEU D 1 183 ? -3.965  -4.404  -35.709 1.00 10.67 ? 183 LEU D CG  1 
ATOM   7929 C  CD1 . LEU D 1 183 ? -4.731  -4.085  -34.404 1.00 12.76 ? 183 LEU D CD1 1 
ATOM   7930 C  CD2 . LEU D 1 183 ? -2.712  -3.552  -35.630 1.00 11.52 ? 183 LEU D CD2 1 
ATOM   7931 N  N   . PRO D 1 184 ? -1.366  -8.113  -36.234 1.00 7.40  ? 184 PRO D N   1 
ATOM   7932 C  CA  . PRO D 1 184 ? -0.982  -9.554  -36.149 1.00 9.02  ? 184 PRO D CA  1 
ATOM   7933 C  C   . PRO D 1 184 ? -1.864  -10.326 -35.232 1.00 11.49 ? 184 PRO D C   1 
ATOM   7934 O  O   . PRO D 1 184 ? -2.871  -9.810  -34.624 1.00 12.62 ? 184 PRO D O   1 
ATOM   7935 C  CB  . PRO D 1 184 ? 0.438   -9.491  -35.582 1.00 10.24 ? 184 PRO D CB  1 
ATOM   7936 C  CG  . PRO D 1 184 ? 0.403   -8.278  -34.683 1.00 9.72  ? 184 PRO D CG  1 
ATOM   7937 C  CD  . PRO D 1 184 ? -0.469  -7.280  -35.440 1.00 8.26  ? 184 PRO D CD  1 
ATOM   7938 N  N   . GLU D 1 185 ? -1.496  -11.635 -35.210 1.00 13.68 ? 185 GLU D N   1 
ATOM   7939 C  CA  . GLU D 1 185 ? -2.125  -12.561 -34.293 1.00 15.42 ? 185 GLU D CA  1 
ATOM   7940 C  C   . GLU D 1 185 ? -1.745  -12.167 -32.879 1.00 12.54 ? 185 GLU D C   1 
ATOM   7941 O  O   . GLU D 1 185 ? -0.606  -11.666 -32.621 1.00 13.10 ? 185 GLU D O   1 
ATOM   7942 C  CB  . GLU D 1 185 ? -1.571  -13.960 -34.566 1.00 18.89 ? 185 GLU D CB  1 
ATOM   7943 C  CG  . GLU D 1 185 ? -1.985  -14.553 -35.914 1.00 25.58 ? 185 GLU D CG  1 
ATOM   7944 C  CD  . GLU D 1 185 ? -1.447  -16.008 -36.038 1.00 37.99 ? 185 GLU D CD  1 
ATOM   7945 O  OE1 . GLU D 1 185 ? -1.334  -16.728 -35.005 1.00 45.54 ? 185 GLU D OE1 1 
ATOM   7946 O  OE2 . GLU D 1 185 ? -1.130  -16.463 -37.167 1.00 48.79 ? 185 GLU D OE2 1 
ATOM   7947 N  N   . ARG D 1 186 ? -2.639  -12.438 -31.921 1.00 12.37 ? 186 ARG D N   1 
ATOM   7948 C  CA  . ARG D 1 186 ? -2.324  -12.316 -30.484 1.00 13.09 ? 186 ARG D CA  1 
ATOM   7949 C  C   . ARG D 1 186 ? -1.859  -10.920 -30.132 1.00 12.04 ? 186 ARG D C   1 
ATOM   7950 O  O   . ARG D 1 186 ? -0.805  -10.704 -29.532 1.00 12.35 ? 186 ARG D O   1 
ATOM   7951 C  CB  . ARG D 1 186 ? -1.355  -13.353 -29.962 1.00 14.56 ? 186 ARG D CB  1 
ATOM   7952 C  CG  . ARG D 1 186 ? -2.017  -14.711 -30.110 1.00 17.84 ? 186 ARG D CG  1 
ATOM   7953 C  CD  . ARG D 1 186 ? -1.055  -15.834 -29.690 1.00 22.03 ? 186 ARG D CD  1 
ATOM   7954 N  NE  . ARG D 1 186 ? 0.027   -16.106 -30.647 1.00 23.41 ? 186 ARG D NE  1 
ATOM   7955 C  CZ  . ARG D 1 186 ? -0.168  -16.657 -31.864 1.00 28.88 ? 186 ARG D CZ  1 
ATOM   7956 N  NH1 . ARG D 1 186 ? -1.409  -16.974 -32.264 1.00 29.84 ? 186 ARG D NH1 1 
ATOM   7957 N  NH2 . ARG D 1 186 ? 0.855   -16.839 -32.689 1.00 33.10 ? 186 ARG D NH2 1 
ATOM   7958 N  N   . THR D 1 187 ? -2.717  -9.976  -30.438 1.00 9.83  ? 187 THR D N   1 
ATOM   7959 C  CA  . THR D 1 187 ? -2.318  -8.606  -30.128 1.00 10.88 ? 187 THR D CA  1 
ATOM   7960 C  C   . THR D 1 187 ? -2.149  -8.315  -28.610 1.00 11.57 ? 187 THR D C   1 
ATOM   7961 O  O   . THR D 1 187 ? -1.573  -7.274  -28.223 1.00 11.08 ? 187 THR D O   1 
ATOM   7962 C  CB  . THR D 1 187 ? -3.294  -7.577  -30.704 1.00 10.71 ? 187 THR D CB  1 
ATOM   7963 O  OG1 . THR D 1 187 ? -4.626  -7.922  -30.314 1.00 13.77 ? 187 THR D OG1 1 
ATOM   7964 C  CG2 . THR D 1 187 ? -3.233  -7.549  -32.255 1.00 12.43 ? 187 THR D CG2 1 
ATOM   7965 N  N   . ALA D 1 188 ? -2.656  -9.213  -27.713 1.00 10.14 ? 188 ALA D N   1 
ATOM   7966 C  CA  . ALA D 1 188 ? -2.437  -9.033  -26.327 1.00 10.89 ? 188 ALA D CA  1 
ATOM   7967 C  C   . ALA D 1 188 ? -0.926  -9.148  -25.953 1.00 8.92  ? 188 ALA D C   1 
ATOM   7968 O  O   . ALA D 1 188 ? -0.564  -8.729  -24.875 1.00 10.51 ? 188 ALA D O   1 
ATOM   7969 C  CB  . ALA D 1 188 ? -3.223  -10.137 -25.586 1.00 11.39 ? 188 ALA D CB  1 
ATOM   7970 N  N   . GLU D 1 189 ? -0.146  -9.755  -26.839 1.00 9.02  ? 189 GLU D N   1 
ATOM   7971 C  CA  . GLU D 1 189 ? 1.299   -9.885  -26.564 1.00 7.86  ? 189 GLU D CA  1 
ATOM   7972 C  C   . GLU D 1 189 ? 2.054   -8.757  -27.341 1.00 6.56  ? 189 GLU D C   1 
ATOM   7973 O  O   . GLU D 1 189 ? 2.104   -8.722  -28.575 1.00 6.97  ? 189 GLU D O   1 
ATOM   7974 C  CB  . GLU D 1 189 ? 1.787   -11.213 -27.162 1.00 10.39 ? 189 GLU D CB  1 
ATOM   7975 C  CG  . GLU D 1 189 ? 1.050   -12.316 -26.367 1.00 13.72 ? 189 GLU D CG  1 
ATOM   7976 C  CD  . GLU D 1 189 ? 1.411   -13.700 -26.853 1.00 20.87 ? 189 GLU D CD  1 
ATOM   7977 O  OE1 . GLU D 1 189 ? 2.549   -13.934 -27.231 1.00 20.86 ? 189 GLU D OE1 1 
ATOM   7978 O  OE2 . GLU D 1 189 ? 0.534   -14.634 -26.755 1.00 25.47 ? 189 GLU D OE2 1 
ATOM   7979 N  N   . TYR D 1 190 ? 2.672   -7.930  -26.519 1.00 5.98  ? 190 TYR D N   1 
ATOM   7980 C  CA  . TYR D 1 190 ? 3.395   -6.786  -27.091 1.00 5.84  ? 190 TYR D CA  1 
ATOM   7981 C  C   . TYR D 1 190 ? 4.455   -6.334  -26.202 1.00 6.12  ? 190 TYR D C   1 
ATOM   7982 O  O   . TYR D 1 190 ? 4.537   -6.687  -24.989 1.00 6.64  ? 190 TYR D O   1 
ATOM   7983 C  CB  . TYR D 1 190 ? 2.343   -5.640  -27.357 1.00 6.27  ? 190 TYR D CB  1 
ATOM   7984 C  CG  . TYR D 1 190 ? 1.586   -5.181  -26.133 1.00 6.33  ? 190 TYR D CG  1 
ATOM   7985 C  CD1 . TYR D 1 190 ? 2.145   -4.291  -25.219 1.00 5.88  ? 190 TYR D CD1 1 
ATOM   7986 C  CD2 . TYR D 1 190 ? 0.293   -5.616  -25.905 1.00 7.43  ? 190 TYR D CD2 1 
ATOM   7987 C  CE1 . TYR D 1 190 ? 1.441   -3.860  -24.111 1.00 7.09  ? 190 TYR D CE1 1 
ATOM   7988 C  CE2 . TYR D 1 190 ? -0.426  -5.192  -24.801 1.00 7.44  ? 190 TYR D CE2 1 
ATOM   7989 C  CZ  . TYR D 1 190 ? 0.157   -4.314  -23.907 1.00 7.14  ? 190 TYR D CZ  1 
ATOM   7990 O  OH  . TYR D 1 190 ? -0.540  -3.878  -22.799 1.00 8.85  ? 190 TYR D OH  1 
ATOM   7991 N  N   . TYR D 1 191 ? 5.365   -5.511  -26.737 1.00 5.54  ? 191 TYR D N   1 
ATOM   7992 C  CA  . TYR D 1 191 ? 6.386   -4.762  -26.091 1.00 6.07  ? 191 TYR D CA  1 
ATOM   7993 C  C   . TYR D 1 191 ? 5.916   -3.303  -25.947 1.00 6.39  ? 191 TYR D C   1 
ATOM   7994 O  O   . TYR D 1 191 ? 5.238   -2.783  -26.846 1.00 6.35  ? 191 TYR D O   1 
ATOM   7995 C  CB  . TYR D 1 191 ? 7.637   -4.697  -26.996 1.00 6.40  ? 191 TYR D CB  1 
ATOM   7996 C  CG  . TYR D 1 191 ? 8.195   -5.990  -27.525 1.00 6.61  ? 191 TYR D CG  1 
ATOM   7997 C  CD1 . TYR D 1 191 ? 9.181   -6.688  -26.764 1.00 7.50  ? 191 TYR D CD1 1 
ATOM   7998 C  CD2 . TYR D 1 191 ? 7.807   -6.492  -28.777 1.00 7.61  ? 191 TYR D CD2 1 
ATOM   7999 C  CE1 . TYR D 1 191 ? 9.744   -7.880  -27.260 1.00 7.26  ? 191 TYR D CE1 1 
ATOM   8000 C  CE2 . TYR D 1 191 ? 8.365   -7.668  -29.254 1.00 8.30  ? 191 TYR D CE2 1 
ATOM   8001 C  CZ  . TYR D 1 191 ? 9.345   -8.314  -28.505 1.00 8.01  ? 191 TYR D CZ  1 
ATOM   8002 O  OH  . TYR D 1 191 ? 9.942   -9.442  -28.998 1.00 11.64 ? 191 TYR D OH  1 
ATOM   8003 N  N   . ARG D 1 192 ? 6.265   -2.680  -24.827 1.00 6.16  ? 192 ARG D N   1 
ATOM   8004 C  CA  . ARG D 1 192 ? 5.830   -1.284  -24.606 1.00 6.77  ? 192 ARG D CA  1 
ATOM   8005 C  C   . ARG D 1 192 ? 6.956   -0.527  -23.995 1.00 6.68  ? 192 ARG D C   1 
ATOM   8006 O  O   . ARG D 1 192 ? 7.586   -0.939  -23.033 1.00 7.68  ? 192 ARG D O   1 
ATOM   8007 C  CB  . ARG D 1 192 ? 4.666   -1.359  -23.584 1.00 8.29  ? 192 ARG D CB  1 
ATOM   8008 C  CG  . ARG D 1 192 ? 4.497   -0.080  -22.870 1.00 15.11 ? 192 ARG D CG  1 
ATOM   8009 C  CD  . ARG D 1 192 ? 3.635   0.759   -23.676 1.00 13.67 ? 192 ARG D CD  1 
ATOM   8010 N  NE  . ARG D 1 192 ? 2.511   0.121   -24.353 1.00 15.78 ? 192 ARG D NE  1 
ATOM   8011 C  CZ  . ARG D 1 192 ? 1.354   -0.169  -23.771 1.00 13.26 ? 192 ARG D CZ  1 
ATOM   8012 N  NH1 . ARG D 1 192 ? 1.179   0.080   -22.481 1.00 19.02 ? 192 ARG D NH1 1 
ATOM   8013 N  NH2 . ARG D 1 192 ? 0.376   -0.725  -24.474 1.00 15.93 ? 192 ARG D NH2 1 
ATOM   8014 N  N   . TYR D 1 193 ? 7.220   0.658   -24.552 1.00 5.93  ? 193 TYR D N   1 
ATOM   8015 C  CA  . TYR D 1 193 ? 8.288   1.500   -23.955 1.00 5.80  ? 193 TYR D CA  1 
ATOM   8016 C  C   . TYR D 1 193 ? 8.041   2.974   -24.288 1.00 6.58  ? 193 TYR D C   1 
ATOM   8017 O  O   . TYR D 1 193 ? 7.268   3.307   -25.188 1.00 6.59  ? 193 TYR D O   1 
ATOM   8018 C  CB  . TYR D 1 193 ? 9.682   1.077   -24.424 1.00 6.30  ? 193 TYR D CB  1 
ATOM   8019 C  CG  . TYR D 1 193 ? 10.004  1.463   -25.842 1.00 5.72  ? 193 TYR D CG  1 
ATOM   8020 C  CD1 . TYR D 1 193 ? 10.746  2.600   -26.108 1.00 6.06  ? 193 TYR D CD1 1 
ATOM   8021 C  CD2 . TYR D 1 193 ? 9.581   0.690   -26.915 1.00 5.92  ? 193 TYR D CD2 1 
ATOM   8022 C  CE1 . TYR D 1 193 ? 11.063  2.963   -27.395 1.00 6.07  ? 193 TYR D CE1 1 
ATOM   8023 C  CE2 . TYR D 1 193 ? 9.887   1.046   -28.216 1.00 6.42  ? 193 TYR D CE2 1 
ATOM   8024 C  CZ  . TYR D 1 193 ? 10.633  2.188   -28.446 1.00 6.00  ? 193 TYR D CZ  1 
ATOM   8025 O  OH  . TYR D 1 193 ? 10.959  2.576   -29.721 1.00 6.87  ? 193 TYR D OH  1 
ATOM   8026 N  N   . ARG D 1 194 ? 8.698   3.803   -23.532 1.00 7.58  ? 194 ARG D N   1 
ATOM   8027 C  CA  . ARG D 1 194 ? 8.588   5.272   -23.808 1.00 8.39  ? 194 ARG D CA  1 
ATOM   8028 C  C   . ARG D 1 194 ? 9.690   5.713   -24.712 1.00 6.36  ? 194 ARG D C   1 
ATOM   8029 O  O   . ARG D 1 194 ? 10.886  5.467   -24.527 1.00 8.05  ? 194 ARG D O   1 
ATOM   8030 C  CB  . ARG D 1 194 ? 8.747   6.050   -22.517 1.00 10.74 ? 194 ARG D CB  1 
ATOM   8031 C  CG  . ARG D 1 194 ? 7.666   5.760   -21.521 1.00 15.67 ? 194 ARG D CG  1 
ATOM   8032 C  CD  . ARG D 1 194 ? 6.424   6.399   -21.979 1.00 22.24 ? 194 ARG D CD  1 
ATOM   8033 N  NE  . ARG D 1 194 ? 5.483   6.353   -20.854 1.00 37.23 ? 194 ARG D NE  1 
ATOM   8034 C  CZ  . ARG D 1 194 ? 5.073   7.439   -20.219 1.00 40.16 ? 194 ARG D CZ  1 
ATOM   8035 N  NH1 . ARG D 1 194 ? 5.550   8.634   -20.575 1.00 40.44 ? 194 ARG D NH1 1 
ATOM   8036 N  NH2 . ARG D 1 194 ? 4.202   7.317   -19.220 1.00 49.20 ? 194 ARG D NH2 1 
ATOM   8037 N  N   . GLY D 1 195 ? 9.267   6.328   -25.824 1.00 5.61  ? 195 GLY D N   1 
ATOM   8038 C  CA  . GLY D 1 195 ? 10.233  6.778   -26.820 1.00 6.07  ? 195 GLY D CA  1 
ATOM   8039 C  C   . GLY D 1 195 ? 9.811   8.026   -27.516 1.00 6.19  ? 195 GLY D C   1 
ATOM   8040 O  O   . GLY D 1 195 ? 9.230   8.943   -26.950 1.00 6.26  ? 195 GLY D O   1 
ATOM   8041 N  N   . SER D 1 196 ? 10.177  8.074   -28.775 1.00 5.24  ? 196 SER D N   1 
ATOM   8042 C  CA  . SER D 1 196 ? 10.068  9.304   -29.568 1.00 4.81  ? 196 SER D CA  1 
ATOM   8043 C  C   . SER D 1 196 ? 9.473   9.019   -30.912 1.00 5.19  ? 196 SER D C   1 
ATOM   8044 O  O   . SER D 1 196 ? 9.424   7.849   -31.429 1.00 5.20  ? 196 SER D O   1 
ATOM   8045 C  CB  . SER D 1 196 ? 11.494  9.931   -29.736 1.00 5.71  ? 196 SER D CB  1 
ATOM   8046 O  OG  . SER D 1 196 ? 12.264  9.196   -30.719 1.00 5.00  ? 196 SER D OG  1 
ATOM   8047 N  N   . LEU D 1 197 ? 9.287   10.112  -31.640 1.00 4.68  ? 197 LEU D N   1 
ATOM   8048 C  CA  . LEU D 1 197 ? 9.046   9.986   -33.076 1.00 5.18  ? 197 LEU D CA  1 
ATOM   8049 C  C   . LEU D 1 197 ? 10.376  9.533   -33.703 1.00 5.04  ? 197 LEU D C   1 
ATOM   8050 O  O   . LEU D 1 197 ? 11.501  9.855   -33.251 1.00 5.90  ? 197 LEU D O   1 
ATOM   8051 C  CB  . LEU D 1 197 ? 8.778   11.395  -33.706 1.00 6.07  ? 197 LEU D CB  1 
ATOM   8052 C  CG  . LEU D 1 197 ? 7.543   12.049  -33.244 1.00 7.64  ? 197 LEU D CG  1 
ATOM   8053 C  CD1 . LEU D 1 197 ? 7.502   13.509  -33.840 1.00 9.40  ? 197 LEU D CD1 1 
ATOM   8054 C  CD2 . LEU D 1 197 ? 6.332   11.349  -33.673 1.00 9.40  ? 197 LEU D CD2 1 
ATOM   8055 N  N   . THR D 1 198 ? 10.271  8.708   -34.777 1.00 4.95  ? 198 THR D N   1 
ATOM   8056 C  CA  . THR D 1 198 ? 11.504  8.245   -35.393 1.00 5.25  ? 198 THR D CA  1 
ATOM   8057 C  C   . THR D 1 198 ? 11.947  9.077   -36.566 1.00 5.48  ? 198 THR D C   1 
ATOM   8058 O  O   . THR D 1 198 ? 12.914  8.734   -37.260 1.00 5.71  ? 198 THR D O   1 
ATOM   8059 C  CB  . THR D 1 198 ? 11.338  6.814   -35.927 1.00 4.77  ? 198 THR D CB  1 
ATOM   8060 O  OG1 . THR D 1 198 ? 10.330  6.780   -36.941 1.00 4.77  ? 198 THR D OG1 1 
ATOM   8061 C  CG2 . THR D 1 198 ? 10.917  5.860   -34.771 1.00 5.02  ? 198 THR D CG2 1 
ATOM   8062 N  N   . THR D 1 199 ? 11.217  10.178  -36.779 1.00 5.51  ? 199 THR D N   1 
ATOM   8063 C  CA  . THR D 1 199 ? 11.582  11.189  -37.814 1.00 5.93  ? 199 THR D CA  1 
ATOM   8064 C  C   . THR D 1 199 ? 11.663  12.522  -37.099 1.00 6.35  ? 199 THR D C   1 
ATOM   8065 O  O   . THR D 1 199 ? 11.015  12.676  -36.058 1.00 6.64  ? 199 THR D O   1 
ATOM   8066 C  CB  . THR D 1 199 ? 10.487  11.384  -38.925 1.00 6.97  ? 199 THR D CB  1 
ATOM   8067 O  OG1 . THR D 1 199 ? 9.245   11.653  -38.325 1.00 9.92  ? 199 THR D OG1 1 
ATOM   8068 C  CG2 . THR D 1 199 ? 10.325  10.031  -39.683 1.00 8.49  ? 199 THR D CG2 1 
ATOM   8069 N  N   . PRO D 1 200 ? 12.358  13.510  -37.717 1.00 5.43  ? 200 PRO D N   1 
ATOM   8070 C  CA  . PRO D 1 200 ? 12.277  14.868  -37.201 1.00 6.68  ? 200 PRO D CA  1 
ATOM   8071 C  C   . PRO D 1 200 ? 10.804  15.261  -36.996 1.00 6.69  ? 200 PRO D C   1 
ATOM   8072 O  O   . PRO D 1 200 ? 9.969   14.940  -37.854 1.00 8.13  ? 200 PRO D O   1 
ATOM   8073 C  CB  . PRO D 1 200 ? 12.931  15.683  -38.351 1.00 6.61  ? 200 PRO D CB  1 
ATOM   8074 C  CG  . PRO D 1 200 ? 14.040  14.748  -38.830 1.00 6.92  ? 200 PRO D CG  1 
ATOM   8075 C  CD  . PRO D 1 200 ? 13.268  13.409  -38.885 1.00 6.18  ? 200 PRO D CD  1 
ATOM   8076 N  N   . PRO D 1 201 ? 10.493  16.017  -35.934 1.00 6.32  ? 201 PRO D N   1 
ATOM   8077 C  CA  . PRO D 1 201 ? 11.450  16.549  -34.969 1.00 6.13  ? 201 PRO D CA  1 
ATOM   8078 C  C   . PRO D 1 201 ? 11.882  15.683  -33.838 1.00 6.62  ? 201 PRO D C   1 
ATOM   8079 O  O   . PRO D 1 201 ? 12.544  16.118  -32.903 1.00 6.49  ? 201 PRO D O   1 
ATOM   8080 C  CB  . PRO D 1 201 ? 10.731  17.802  -34.357 1.00 6.78  ? 201 PRO D CB  1 
ATOM   8081 C  CG  . PRO D 1 201 ? 9.452   17.882  -35.148 1.00 9.87  ? 201 PRO D CG  1 
ATOM   8082 C  CD  . PRO D 1 201 ? 9.171   16.556  -35.764 1.00 8.22  ? 201 PRO D CD  1 
ATOM   8083 N  N   . CYS D 1 202 ? 11.495  14.388  -33.916 1.00 5.47  ? 202 CYS D N   1 
ATOM   8084 C  CA  . CYS D 1 202 ? 12.072  13.385  -32.940 1.00 5.96  ? 202 CYS D CA  1 
ATOM   8085 C  C   . CYS D 1 202 ? 11.604  13.627  -31.460 1.00 6.38  ? 202 CYS D C   1 
ATOM   8086 O  O   . CYS D 1 202 ? 12.257  13.204  -30.513 1.00 7.27  ? 202 CYS D O   1 
ATOM   8087 C  CB  . CYS D 1 202 ? 13.581  13.323  -32.880 1.00 6.92  ? 202 CYS D CB  1 
ATOM   8088 S  SG  . CYS D 1 202 ? 14.362  12.948  -34.513 1.00 7.11  ? 202 CYS D SG  1 
ATOM   8089 N  N   . ASN D 1 203 ? 10.424  14.218  -31.347 1.00 6.01  ? 203 ASN D N   1 
ATOM   8090 C  CA  . ASN D 1 203 ? 9.953   14.588  -30.004 1.00 7.06  ? 203 ASN D CA  1 
ATOM   8091 C  C   . ASN D 1 203 ? 9.833   13.358  -29.168 1.00 6.73  ? 203 ASN D C   1 
ATOM   8092 O  O   . ASN D 1 203 ? 9.302   12.327  -29.624 1.00 5.73  ? 203 ASN D O   1 
ATOM   8093 C  CB  . ASN D 1 203 ? 8.597   15.264  -30.123 1.00 8.04  ? 203 ASN D CB  1 
ATOM   8094 C  CG  . ASN D 1 203 ? 8.702   16.520  -30.987 1.00 10.69 ? 203 ASN D CG  1 
ATOM   8095 O  OD1 . ASN D 1 203 ? 8.623   16.398  -32.138 1.00 13.58 ? 203 ASN D OD1 1 
ATOM   8096 N  ND2 . ASN D 1 203 ? 9.107   17.593  -30.424 1.00 13.20 ? 203 ASN D ND2 1 
ATOM   8097 N  N   . PRO D 1 204 ? 10.262  13.386  -27.926 1.00 6.32  ? 204 PRO D N   1 
ATOM   8098 C  CA  . PRO D 1 204 ? 10.203  12.193  -27.025 1.00 7.67  ? 204 PRO D CA  1 
ATOM   8099 C  C   . PRO D 1 204 ? 8.835   12.067  -26.330 1.00 8.47  ? 204 PRO D C   1 
ATOM   8100 O  O   . PRO D 1 204 ? 8.743   12.099  -25.030 1.00 9.62  ? 204 PRO D O   1 
ATOM   8101 C  CB  . PRO D 1 204 ? 11.350  12.434  -25.997 1.00 8.46  ? 204 PRO D CB  1 
ATOM   8102 C  CG  . PRO D 1 204 ? 11.347  13.943  -25.870 1.00 8.05  ? 204 PRO D CG  1 
ATOM   8103 C  CD  . PRO D 1 204 ? 11.114  14.441  -27.330 1.00 7.88  ? 204 PRO D CD  1 
ATOM   8104 N  N   . THR D 1 205 ? 7.790   11.976  -27.135 1.00 6.68  ? 205 THR D N   1 
ATOM   8105 C  CA  . THR D 1 205 ? 6.417   12.074  -26.715 1.00 6.69  ? 205 THR D CA  1 
ATOM   8106 C  C   . THR D 1 205 ? 5.601   10.873  -27.117 1.00 6.33  ? 205 THR D C   1 
ATOM   8107 O  O   . THR D 1 205 ? 4.372   10.935  -27.070 1.00 7.06  ? 205 THR D O   1 
ATOM   8108 C  CB  . THR D 1 205 ? 5.759   13.301  -27.358 1.00 7.81  ? 205 THR D CB  1 
ATOM   8109 O  OG1 . THR D 1 205 ? 5.983   13.241  -28.793 1.00 8.21  ? 205 THR D OG1 1 
ATOM   8110 C  CG2 . THR D 1 205 ? 6.410   14.599  -26.858 1.00 8.82  ? 205 THR D CG2 1 
ATOM   8111 N  N   . VAL D 1 206 ? 6.269   9.743   -27.483 1.00 5.60  ? 206 VAL D N   1 
ATOM   8112 C  CA  . VAL D 1 206 ? 5.498   8.595   -27.983 1.00 6.10  ? 206 VAL D CA  1 
ATOM   8113 C  C   . VAL D 1 206 ? 5.581   7.432   -27.008 1.00 5.90  ? 206 VAL D C   1 
ATOM   8114 O  O   . VAL D 1 206 ? 6.640   6.976   -26.617 1.00 6.90  ? 206 VAL D O   1 
ATOM   8115 C  CB  . VAL D 1 206 ? 6.121   8.142   -29.307 1.00 5.98  ? 206 VAL D CB  1 
ATOM   8116 C  CG1 . VAL D 1 206 ? 5.381   6.903   -29.764 1.00 6.62  ? 206 VAL D CG1 1 
ATOM   8117 C  CG2 . VAL D 1 206 ? 6.068   9.168   -30.418 1.00 7.60  ? 206 VAL D CG2 1 
ATOM   8118 N  N   . LEU D 1 207 ? 4.397   6.934   -26.691 1.00 5.18  ? 207 LEU D N   1 
ATOM   8119 C  CA  . LEU D 1 207 ? 4.298   5.633   -26.008 1.00 6.37  ? 207 LEU D CA  1 
ATOM   8120 C  C   . LEU D 1 207 ? 4.169   4.583   -27.112 1.00 5.69  ? 207 LEU D C   1 
ATOM   8121 O  O   . LEU D 1 207 ? 3.229   4.548   -27.876 1.00 6.15  ? 207 LEU D O   1 
ATOM   8122 C  CB  . LEU D 1 207 ? 3.029   5.607   -25.150 1.00 8.50  ? 207 LEU D CB  1 
ATOM   8123 C  CG  . LEU D 1 207 ? 2.983   4.337   -24.300 1.00 9.61  ? 207 LEU D CG  1 
ATOM   8124 C  CD1 . LEU D 1 207 ? 4.105   4.291   -23.275 1.00 12.49 ? 207 LEU D CD1 1 
ATOM   8125 C  CD2 . LEU D 1 207 ? 1.657   4.282   -23.663 1.00 15.18 ? 207 LEU D CD2 1 
ATOM   8126 N  N   . TRP D 1 208 ? 5.210   3.763   -27.234 1.00 5.47  ? 208 TRP D N   1 
ATOM   8127 C  CA  . TRP D 1 208 ? 5.291   2.720   -28.269 1.00 5.30  ? 208 TRP D CA  1 
ATOM   8128 C  C   . TRP D 1 208 ? 4.688   1.414   -27.825 1.00 5.15  ? 208 TRP D C   1 
ATOM   8129 O  O   . TRP D 1 208 ? 5.036   0.961   -26.705 1.00 6.55  ? 208 TRP D O   1 
ATOM   8130 C  CB  . TRP D 1 208 ? 6.774   2.488   -28.672 1.00 5.45  ? 208 TRP D CB  1 
ATOM   8131 C  CG  . TRP D 1 208 ? 7.324   3.546   -29.565 1.00 5.11  ? 208 TRP D CG  1 
ATOM   8132 C  CD1 . TRP D 1 208 ? 8.036   4.713   -29.219 1.00 5.29  ? 208 TRP D CD1 1 
ATOM   8133 C  CD2 . TRP D 1 208 ? 7.136   3.586   -30.987 1.00 5.25  ? 208 TRP D CD2 1 
ATOM   8134 N  NE1 . TRP D 1 208 ? 8.259   5.449   -30.314 1.00 5.30  ? 208 TRP D NE1 1 
ATOM   8135 C  CE2 . TRP D 1 208 ? 7.725   4.826   -31.448 1.00 4.67  ? 208 TRP D CE2 1 
ATOM   8136 C  CE3 . TRP D 1 208 ? 6.462   2.771   -31.915 1.00 5.41  ? 208 TRP D CE3 1 
ATOM   8137 C  CZ2 . TRP D 1 208 ? 7.688   5.225   -32.774 1.00 5.32  ? 208 TRP D CZ2 1 
ATOM   8138 C  CZ3 . TRP D 1 208 ? 6.441   3.142   -33.258 1.00 5.72  ? 208 TRP D CZ3 1 
ATOM   8139 C  CH2 . TRP D 1 208 ? 7.053   4.327   -33.711 1.00 6.02  ? 208 TRP D CH2 1 
ATOM   8140 N  N   . THR D 1 209 ? 3.944   0.788   -28.696 1.00 4.61  ? 209 THR D N   1 
ATOM   8141 C  CA  . THR D 1 209 ? 3.472   -0.600  -28.484 1.00 5.30  ? 209 THR D CA  1 
ATOM   8142 C  C   . THR D 1 209 ? 3.897   -1.341  -29.730 1.00 5.08  ? 209 THR D C   1 
ATOM   8143 O  O   . THR D 1 209 ? 3.437   -0.983  -30.850 1.00 6.32  ? 209 THR D O   1 
ATOM   8144 C  CB  . THR D 1 209 ? 1.942   -0.630  -28.371 1.00 5.80  ? 209 THR D CB  1 
ATOM   8145 O  OG1 . THR D 1 209 ? 1.599   0.091   -27.178 1.00 6.32  ? 209 THR D OG1 1 
ATOM   8146 C  CG2 . THR D 1 209 ? 1.439   -2.110  -28.191 1.00 7.35  ? 209 THR D CG2 1 
ATOM   8147 N  N   . VAL D 1 210 ? 4.803   -2.286  -29.618 1.00 5.13  ? 210 VAL D N   1 
ATOM   8148 C  CA  . VAL D 1 210 ? 5.248   -3.081  -30.774 1.00 4.99  ? 210 VAL D CA  1 
ATOM   8149 C  C   . VAL D 1 210 ? 4.692   -4.490  -30.559 1.00 4.99  ? 210 VAL D C   1 
ATOM   8150 O  O   . VAL D 1 210 ? 4.977   -5.099  -29.533 1.00 5.85  ? 210 VAL D O   1 
ATOM   8151 C  CB  . VAL D 1 210 ? 6.779   -3.166  -30.806 1.00 5.43  ? 210 VAL D CB  1 
ATOM   8152 C  CG1 . VAL D 1 210 ? 7.252   -3.938  -32.042 1.00 6.39  ? 210 VAL D CG1 1 
ATOM   8153 C  CG2 . VAL D 1 210 ? 7.376   -1.723  -30.834 1.00 5.48  ? 210 VAL D CG2 1 
ATOM   8154 N  N   . PHE D 1 211 ? 3.854   -4.945  -31.445 1.00 4.59  ? 211 PHE D N   1 
ATOM   8155 C  CA  . PHE D 1 211 ? 3.277   -6.306  -31.247 1.00 5.13  ? 211 PHE D CA  1 
ATOM   8156 C  C   . PHE D 1 211 ? 4.401   -7.348  -31.374 1.00 5.36  ? 211 PHE D C   1 
ATOM   8157 O  O   . PHE D 1 211 ? 5.324   -7.272  -32.169 1.00 6.21  ? 211 PHE D O   1 
ATOM   8158 C  CB  . PHE D 1 211 ? 2.173   -6.539  -32.211 1.00 6.18  ? 211 PHE D CB  1 
ATOM   8159 C  CG  . PHE D 1 211 ? 1.010   -5.596  -31.979 1.00 6.47  ? 211 PHE D CG  1 
ATOM   8160 C  CD1 . PHE D 1 211 ? 0.227   -5.751  -30.802 1.00 7.15  ? 211 PHE D CD1 1 
ATOM   8161 C  CD2 . PHE D 1 211 ? 0.744   -4.510  -32.830 1.00 8.28  ? 211 PHE D CD2 1 
ATOM   8162 C  CE1 . PHE D 1 211 ? -0.770  -4.877  -30.494 1.00 7.64  ? 211 PHE D CE1 1 
ATOM   8163 C  CE2 . PHE D 1 211 ? -0.349  -3.671  -32.572 1.00 8.78  ? 211 PHE D CE2 1 
ATOM   8164 C  CZ  . PHE D 1 211 ? -1.097  -3.832  -31.367 1.00 8.45  ? 211 PHE D CZ  1 
ATOM   8165 N  N   . ARG D 1 212 ? 4.239   -8.433  -30.578 1.00 6.91  ? 212 ARG D N   1 
ATOM   8166 C  CA  . ARG D 1 212 ? 5.266   -9.491  -30.538 1.00 7.26  ? 212 ARG D CA  1 
ATOM   8167 C  C   . ARG D 1 212 ? 5.295   -10.255 -31.838 1.00 7.37  ? 212 ARG D C   1 
ATOM   8168 O  O   . ARG D 1 212 ? 6.395   -10.619 -32.298 1.00 9.15  ? 212 ARG D O   1 
ATOM   8169 C  CB  . ARG D 1 212 ? 4.891   -10.390 -29.398 1.00 7.81  ? 212 ARG D CB  1 
ATOM   8170 C  CG  . ARG D 1 212 ? 5.970   -11.512 -29.271 1.00 9.16  ? 212 ARG D CG  1 
ATOM   8171 C  CD  . ARG D 1 212 ? 5.479   -12.572 -28.305 1.00 11.03 ? 212 ARG D CD  1 
ATOM   8172 N  NE  . ARG D 1 212 ? 6.549   -13.545 -28.038 1.00 12.72 ? 212 ARG D NE  1 
ATOM   8173 C  CZ  . ARG D 1 212 ? 6.415   -14.465 -27.085 1.00 15.83 ? 212 ARG D CZ  1 
ATOM   8174 N  NH1 . ARG D 1 212 ? 5.271   -14.671 -26.526 1.00 15.45 ? 212 ARG D NH1 1 
ATOM   8175 N  NH2 . ARG D 1 212 ? 7.453   -15.258 -26.819 1.00 21.39 ? 212 ARG D NH2 1 
ATOM   8176 N  N   . ASN D 1 213 ? 4.182   -10.433 -32.474 1.00 7.05  ? 213 ASN D N   1 
ATOM   8177 C  CA  . ASN D 1 213 ? 4.127   -11.298 -33.658 1.00 8.33  ? 213 ASN D CA  1 
ATOM   8178 C  C   . ASN D 1 213 ? 4.112   -10.423 -34.924 1.00 8.82  ? 213 ASN D C   1 
ATOM   8179 O  O   . ASN D 1 213 ? 3.372   -9.403  -34.989 1.00 7.64  ? 213 ASN D O   1 
ATOM   8180 C  CB  . ASN D 1 213 ? 2.833   -12.094 -33.577 1.00 9.87  ? 213 ASN D CB  1 
ATOM   8181 C  CG  . ASN D 1 213 ? 2.890   -13.101 -32.411 1.00 12.45 ? 213 ASN D CG  1 
ATOM   8182 O  OD1 . ASN D 1 213 ? 2.039   -13.049 -31.578 1.00 18.12 ? 213 ASN D OD1 1 
ATOM   8183 N  ND2 . ASN D 1 213 ? 3.957   -13.838 -32.297 1.00 15.68 ? 213 ASN D ND2 1 
ATOM   8184 N  N   . PRO D 1 214 ? 4.827   -10.806 -35.934 1.00 7.83  ? 214 PRO D N   1 
ATOM   8185 C  CA  . PRO D 1 214 ? 4.759   -10.091 -37.241 1.00 7.66  ? 214 PRO D CA  1 
ATOM   8186 C  C   . PRO D 1 214 ? 3.622   -10.495 -38.093 1.00 7.38  ? 214 PRO D C   1 
ATOM   8187 O  O   . PRO D 1 214 ? 2.979   -11.511 -37.856 1.00 8.46  ? 214 PRO D O   1 
ATOM   8188 C  CB  . PRO D 1 214 ? 6.104   -10.468 -37.904 1.00 7.46  ? 214 PRO D CB  1 
ATOM   8189 C  CG  . PRO D 1 214 ? 6.245   -11.932 -37.466 1.00 9.49  ? 214 PRO D CG  1 
ATOM   8190 C  CD  . PRO D 1 214 ? 5.816   -11.942 -35.947 1.00 9.07  ? 214 PRO D CD  1 
ATOM   8191 N  N   . VAL D 1 215 ? 3.340   -9.685  -39.126 1.00 6.33  ? 215 VAL D N   1 
ATOM   8192 C  CA  . VAL D 1 215 ? 2.476   -10.123 -40.238 1.00 6.34  ? 215 VAL D CA  1 
ATOM   8193 C  C   . VAL D 1 215 ? 3.323   -10.385 -41.414 1.00 5.81  ? 215 VAL D C   1 
ATOM   8194 O  O   . VAL D 1 215 ? 4.551   -10.120 -41.391 1.00 7.08  ? 215 VAL D O   1 
ATOM   8195 C  CB  . VAL D 1 215 ? 1.413   -9.047  -40.601 1.00 6.73  ? 215 VAL D CB  1 
ATOM   8196 C  CG1 . VAL D 1 215 ? 0.551   -8.766  -39.388 1.00 8.32  ? 215 VAL D CG1 1 
ATOM   8197 C  CG2 . VAL D 1 215 ? 2.081   -7.727  -41.155 1.00 7.35  ? 215 VAL D CG2 1 
ATOM   8198 N  N   . GLN D 1 216 ? 2.794   -10.942 -42.473 1.00 6.25  ? 216 GLN D N   1 
ATOM   8199 C  CA  . GLN D 1 216 ? 3.550   -11.181 -43.680 1.00 6.22  ? 216 GLN D CA  1 
ATOM   8200 C  C   . GLN D 1 216 ? 2.929   -10.467 -44.851 1.00 6.58  ? 216 GLN D C   1 
ATOM   8201 O  O   . GLN D 1 216 ? 1.698   -10.317 -44.906 1.00 7.29  ? 216 GLN D O   1 
ATOM   8202 C  CB  . GLN D 1 216 ? 3.477   -12.705 -44.063 1.00 8.22  ? 216 GLN D CB  1 
ATOM   8203 C  CG  . GLN D 1 216 ? 4.211   -13.586 -43.125 1.00 9.04  ? 216 GLN D CG  1 
ATOM   8204 C  CD  . GLN D 1 216 ? 3.990   -15.068 -43.513 1.00 11.89 ? 216 GLN D CD  1 
ATOM   8205 O  OE1 . GLN D 1 216 ? 3.581   -15.543 -44.602 1.00 11.37 ? 216 GLN D OE1 1 
ATOM   8206 N  NE2 . GLN D 1 216 ? 4.156   -15.825 -42.454 1.00 20.09 ? 216 GLN D NE2 1 
ATOM   8207 N  N   . ILE D 1 217 ? 3.747   -9.996  -45.744 1.00 5.60  ? 217 ILE D N   1 
ATOM   8208 C  CA  . ILE D 1 217 ? 3.318   -9.528  -47.098 1.00 5.54  ? 217 ILE D CA  1 
ATOM   8209 C  C   . ILE D 1 217 ? 4.235   -10.254 -48.129 1.00 5.43  ? 217 ILE D C   1 
ATOM   8210 O  O   . ILE D 1 217 ? 5.343   -10.686 -47.707 1.00 5.78  ? 217 ILE D O   1 
ATOM   8211 C  CB  . ILE D 1 217 ? 3.347   -7.955  -47.264 1.00 5.44  ? 217 ILE D CB  1 
ATOM   8212 C  CG1 . ILE D 1 217 ? 4.797   -7.475  -47.268 1.00 6.22  ? 217 ILE D CG1 1 
ATOM   8213 C  CG2 . ILE D 1 217 ? 2.477   -7.311  -46.197 1.00 6.56  ? 217 ILE D CG2 1 
ATOM   8214 C  CD1 . ILE D 1 217 ? 4.895   -5.924  -47.410 1.00 7.92  ? 217 ILE D CD1 1 
ATOM   8215 N  N   . SER D 1 218 ? 3.832   -10.322 -49.376 1.00 5.25  ? 218 SER D N   1 
ATOM   8216 C  CA  . SER D 1 218 ? 4.688   -11.065 -50.278 1.00 5.43  ? 218 SER D CA  1 
ATOM   8217 C  C   . SER D 1 218 ? 5.893   -10.328 -50.789 1.00 6.49  ? 218 SER D C   1 
ATOM   8218 O  O   . SER D 1 218 ? 5.949   -9.031  -50.682 1.00 6.63  ? 218 SER D O   1 
ATOM   8219 C  CB  . SER D 1 218 ? 3.911   -11.569 -51.446 1.00 6.55  ? 218 SER D CB  1 
ATOM   8220 O  OG  . SER D 1 218 ? 3.515   -10.430 -52.236 1.00 7.48  ? 218 SER D OG  1 
ATOM   8221 N  N   . GLN D 1 219 ? 6.850   -11.007 -51.378 1.00 7.02  ? 219 GLN D N   1 
ATOM   8222 C  CA  . GLN D 1 219 ? 7.949   -10.350 -52.030 1.00 8.56  ? 219 GLN D CA  1 
ATOM   8223 C  C   . GLN D 1 219 ? 7.453   -9.347  -53.082 1.00 8.43  ? 219 GLN D C   1 
ATOM   8224 O  O   . GLN D 1 219 ? 8.050   -8.276  -53.217 1.00 8.30  ? 219 GLN D O   1 
ATOM   8225 C  CB  . GLN D 1 219 ? 8.775   -11.467 -52.741 1.00 11.01 ? 219 GLN D CB  1 
ATOM   8226 C  CG  . GLN D 1 219 ? 10.144  -10.981 -53.226 1.00 16.98 ? 219 GLN D CG  1 
ATOM   8227 C  CD  . GLN D 1 219 ? 10.160  -10.217 -54.522 1.00 21.72 ? 219 GLN D CD  1 
ATOM   8228 O  OE1 . GLN D 1 219 ? 10.993  -9.299  -54.686 1.00 27.75 ? 219 GLN D OE1 1 
ATOM   8229 N  NE2 . GLN D 1 219 ? 9.217   -10.536 -55.413 1.00 25.06 ? 219 GLN D NE2 1 
ATOM   8230 N  N   . GLU D 1 220 ? 6.437   -9.742  -53.823 1.00 8.52  ? 220 GLU D N   1 
ATOM   8231 C  CA  . GLU D 1 220 ? 5.987   -8.831  -54.871 1.00 9.38  ? 220 GLU D CA  1 
ATOM   8232 C  C   . GLU D 1 220 ? 5.369   -7.593  -54.237 1.00 8.02  ? 220 GLU D C   1 
ATOM   8233 O  O   . GLU D 1 220 ? 5.607   -6.458  -54.752 1.00 9.16  ? 220 GLU D O   1 
ATOM   8234 C  CB  . GLU D 1 220 ? 4.989   -9.509  -55.810 1.00 11.62 ? 220 GLU D CB  1 
ATOM   8235 C  CG  . GLU D 1 220 ? 5.626   -10.630 -56.643 1.00 13.57 ? 220 GLU D CG  1 
ATOM   8236 C  CD  . GLU D 1 220 ? 5.842   -11.924 -55.928 1.00 20.12 ? 220 GLU D CD  1 
ATOM   8237 O  OE1 . GLU D 1 220 ? 5.393   -12.154 -54.790 1.00 17.70 ? 220 GLU D OE1 1 
ATOM   8238 O  OE2 . GLU D 1 220 ? 6.485   -12.775 -56.571 1.00 27.57 ? 220 GLU D OE2 1 
ATOM   8239 N  N   . GLN D 1 221 ? 4.703   -7.710  -53.089 1.00 6.63  ? 221 GLN D N   1 
ATOM   8240 C  CA  . GLN D 1 221 ? 4.165   -6.489  -52.427 1.00 7.10  ? 221 GLN D CA  1 
ATOM   8241 C  C   . GLN D 1 221 ? 5.282   -5.673  -51.893 1.00 6.78  ? 221 GLN D C   1 
ATOM   8242 O  O   . GLN D 1 221 ? 5.241   -4.412  -52.042 1.00 7.68  ? 221 GLN D O   1 
ATOM   8243 C  CB  . GLN D 1 221 ? 3.263   -6.911  -51.301 1.00 6.22  ? 221 GLN D CB  1 
ATOM   8244 C  CG  . GLN D 1 221 ? 1.917   -7.549  -51.762 1.00 6.06  ? 221 GLN D CG  1 
ATOM   8245 C  CD  . GLN D 1 221 ? 1.056   -7.929  -50.649 1.00 5.43  ? 221 GLN D CD  1 
ATOM   8246 O  OE1 . GLN D 1 221 ? 1.352   -8.843  -49.837 1.00 6.56  ? 221 GLN D OE1 1 
ATOM   8247 N  NE2 . GLN D 1 221 ? -0.102  -7.241  -50.475 1.00 5.32  ? 221 GLN D NE2 1 
ATOM   8248 N  N   . LEU D 1 222 ? 6.352   -6.275  -51.340 1.00 7.31  ? 222 LEU D N   1 
ATOM   8249 C  CA  . LEU D 1 222 ? 7.476   -5.486  -50.868 1.00 7.41  ? 222 LEU D CA  1 
ATOM   8250 C  C   . LEU D 1 222 ? 8.166   -4.789  -52.022 1.00 8.41  ? 222 LEU D C   1 
ATOM   8251 O  O   . LEU D 1 222 ? 8.581   -3.635  -51.871 1.00 7.70  ? 222 LEU D O   1 
ATOM   8252 C  CB  . LEU D 1 222 ? 8.434   -6.450  -50.137 1.00 8.76  ? 222 LEU D CB  1 
ATOM   8253 C  CG  . LEU D 1 222 ? 8.103   -6.658  -48.735 1.00 10.46 ? 222 LEU D CG  1 
ATOM   8254 C  CD1 . LEU D 1 222 ? 8.802   -7.923  -48.194 1.00 11.29 ? 222 LEU D CD1 1 
ATOM   8255 C  CD2 . LEU D 1 222 ? 8.467   -5.461  -47.801 1.00 10.47 ? 222 LEU D CD2 1 
ATOM   8256 N  N   . LEU D 1 223 ? 8.385   -5.483  -53.135 1.00 8.32  ? 223 LEU D N   1 
ATOM   8257 C  CA  . LEU D 1 223 ? 9.122   -4.872  -54.227 1.00 8.55  ? 223 LEU D CA  1 
ATOM   8258 C  C   . LEU D 1 223 ? 8.276   -3.724  -54.747 1.00 9.74  ? 223 LEU D C   1 
ATOM   8259 O  O   . LEU D 1 223 ? 8.882   -2.668  -55.155 1.00 10.17 ? 223 LEU D O   1 
ATOM   8260 C  CB  . LEU D 1 223 ? 9.323   -5.948  -55.360 1.00 10.08 ? 223 LEU D CB  1 
ATOM   8261 C  CG  . LEU D 1 223 ? 10.075  -5.399  -56.570 1.00 10.78 ? 223 LEU D CG  1 
ATOM   8262 C  CD1 . LEU D 1 223 ? 11.454  -4.942  -56.111 1.00 13.37 ? 223 LEU D CD1 1 
ATOM   8263 C  CD2 . LEU D 1 223 ? 10.149  -6.547  -57.590 1.00 13.27 ? 223 LEU D CD2 1 
ATOM   8264 N  N   . ALA D 1 224 ? 6.966   -3.874  -54.803 1.00 9.37  ? 224 ALA D N   1 
ATOM   8265 C  CA  . ALA D 1 224 ? 6.151   -2.761  -55.309 1.00 10.89 ? 224 ALA D CA  1 
ATOM   8266 C  C   . ALA D 1 224 ? 6.242   -1.552  -54.345 1.00 11.66 ? 224 ALA D C   1 
ATOM   8267 O  O   . ALA D 1 224 ? 6.491   -0.455  -54.774 1.00 12.91 ? 224 ALA D O   1 
ATOM   8268 C  CB  . ALA D 1 224 ? 4.739   -3.213  -55.551 1.00 14.11 ? 224 ALA D CB  1 
ATOM   8269 N  N   . LEU D 1 225 ? 6.192   -1.791  -53.041 1.00 9.11  ? 225 LEU D N   1 
ATOM   8270 C  CA  . LEU D 1 225 ? 6.372   -0.777  -52.053 1.00 9.56  ? 225 LEU D CA  1 
ATOM   8271 C  C   . LEU D 1 225 ? 7.718   -0.085  -52.212 1.00 10.07 ? 225 LEU D C   1 
ATOM   8272 O  O   . LEU D 1 225 ? 7.800   1.157   -52.105 1.00 11.54 ? 225 LEU D O   1 
ATOM   8273 C  CB  . LEU D 1 225 ? 6.155   -1.340  -50.662 1.00 9.96  ? 225 LEU D CB  1 
ATOM   8274 C  CG  . LEU D 1 225 ? 6.389   -0.332  -49.556 1.00 10.32 ? 225 LEU D CG  1 
ATOM   8275 C  CD1 . LEU D 1 225 ? 5.333   0.814   -49.623 1.00 11.10 ? 225 LEU D CD1 1 
ATOM   8276 C  CD2 . LEU D 1 225 ? 6.193   -1.110  -48.248 1.00 11.99 ? 225 LEU D CD2 1 
ATOM   8277 N  N   . GLU D 1 226 ? 8.796   -0.847  -52.394 1.00 9.24  ? 226 GLU D N   1 
ATOM   8278 C  CA  . GLU D 1 226 ? 10.169  -0.373  -52.473 1.00 8.92  ? 226 GLU D CA  1 
ATOM   8279 C  C   . GLU D 1 226 ? 10.462  0.354   -53.750 1.00 9.66  ? 226 GLU D C   1 
ATOM   8280 O  O   . GLU D 1 226 ? 11.521  0.969   -53.832 1.00 13.92 ? 226 GLU D O   1 
ATOM   8281 C  CB  . GLU D 1 226 ? 11.128  -1.590  -52.338 1.00 9.23  ? 226 GLU D CB  1 
ATOM   8282 C  CG  . GLU D 1 226 ? 11.208  -2.204  -50.937 1.00 8.65  ? 226 GLU D CG  1 
ATOM   8283 C  CD  . GLU D 1 226 ? 11.596  -3.624  -50.978 1.00 11.90 ? 226 GLU D CD  1 
ATOM   8284 O  OE1 . GLU D 1 226 ? 11.817  -4.234  -52.065 1.00 11.16 ? 226 GLU D OE1 1 
ATOM   8285 O  OE2 . GLU D 1 226 ? 11.608  -4.232  -49.925 1.00 12.52 ? 226 GLU D OE2 1 
ATOM   8286 N  N   . THR D 1 227 ? 9.607   0.272   -54.749 1.00 8.23  ? 227 THR D N   1 
ATOM   8287 C  CA  . THR D 1 227 ? 9.952   0.904   -56.033 1.00 9.40  ? 227 THR D CA  1 
ATOM   8288 C  C   . THR D 1 227 ? 8.856   1.841   -56.449 1.00 10.79 ? 227 THR D C   1 
ATOM   8289 O  O   . THR D 1 227 ? 9.037   2.465   -57.497 1.00 13.83 ? 227 THR D O   1 
ATOM   8290 C  CB  . THR D 1 227 ? 10.163  -0.161  -57.134 1.00 11.78 ? 227 THR D CB  1 
ATOM   8291 O  OG1 . THR D 1 227 ? 8.935   -0.921  -57.285 1.00 11.50 ? 227 THR D OG1 1 
ATOM   8292 C  CG2 . THR D 1 227 ? 11.387  -1.052  -56.840 1.00 12.73 ? 227 THR D CG2 1 
ATOM   8293 N  N   . ALA D 1 228 ? 7.790   2.049   -55.672 1.00 11.12 ? 228 ALA D N   1 
ATOM   8294 C  CA  . ALA D 1 228 ? 6.675   2.841   -56.188 1.00 10.51 ? 228 ALA D CA  1 
ATOM   8295 C  C   . ALA D 1 228 ? 6.866   4.348   -55.917 1.00 12.05 ? 228 ALA D C   1 
ATOM   8296 O  O   . ALA D 1 228 ? 6.143   5.141   -56.562 1.00 14.51 ? 228 ALA D O   1 
ATOM   8297 C  CB  . ALA D 1 228 ? 5.386   2.378   -55.528 1.00 13.50 ? 228 ALA D CB  1 
ATOM   8298 N  N   . LEU D 1 229 ? 7.647   4.758   -54.949 1.00 10.63 ? 229 LEU D N   1 
ATOM   8299 C  CA  . LEU D 1 229 ? 7.482   6.106   -54.417 1.00 10.01 ? 229 LEU D CA  1 
ATOM   8300 C  C   . LEU D 1 229 ? 8.780   6.897   -54.496 1.00 11.51 ? 229 LEU D C   1 
ATOM   8301 O  O   . LEU D 1 229 ? 9.882   6.392   -54.418 1.00 9.73  ? 229 LEU D O   1 
ATOM   8302 C  CB  . LEU D 1 229 ? 7.068   6.049   -52.941 1.00 9.40  ? 229 LEU D CB  1 
ATOM   8303 C  CG  . LEU D 1 229 ? 5.711   5.290   -52.696 1.00 9.73  ? 229 LEU D CG  1 
ATOM   8304 C  CD1 . LEU D 1 229 ? 5.494   5.106   -51.223 1.00 11.70 ? 229 LEU D CD1 1 
ATOM   8305 C  CD2 . LEU D 1 229 ? 4.522   6.019   -53.289 1.00 12.64 ? 229 LEU D CD2 1 
ATOM   8306 N  N   . TYR D 1 230 ? 8.601   8.217   -54.609 1.00 11.63 ? 230 TYR D N   1 
ATOM   8307 C  CA  . TYR D 1 230 ? 9.680   9.205   -54.581 1.00 11.07 ? 230 TYR D CA  1 
ATOM   8308 C  C   . TYR D 1 230 ? 9.489   10.196  -53.499 1.00 10.67 ? 230 TYR D C   1 
ATOM   8309 O  O   . TYR D 1 230 ? 8.371   10.565  -53.164 1.00 10.72 ? 230 TYR D O   1 
ATOM   8310 C  CB  . TYR D 1 230 ? 9.741   9.901   -55.955 1.00 11.91 ? 230 TYR D CB  1 
ATOM   8311 C  CG  . TYR D 1 230 ? 10.240  9.008   -57.027 1.00 12.84 ? 230 TYR D CG  1 
ATOM   8312 C  CD1 . TYR D 1 230 ? 11.585  9.020   -57.359 1.00 14.75 ? 230 TYR D CD1 1 
ATOM   8313 C  CD2 . TYR D 1 230 ? 9.389   8.001   -57.566 1.00 16.12 ? 230 TYR D CD2 1 
ATOM   8314 C  CE1 . TYR D 1 230 ? 12.075  8.111   -58.331 1.00 18.52 ? 230 TYR D CE1 1 
ATOM   8315 C  CE2 . TYR D 1 230 ? 9.849   7.099   -58.517 1.00 20.64 ? 230 TYR D CE2 1 
ATOM   8316 C  CZ  . TYR D 1 230 ? 11.199  7.162   -58.870 1.00 20.95 ? 230 TYR D CZ  1 
ATOM   8317 O  OH  . TYR D 1 230 ? 11.696  6.233   -59.812 1.00 24.37 ? 230 TYR D OH  1 
ATOM   8318 N  N   . CYS D 1 231 ? 10.615  10.721  -52.969 1.00 11.30 ? 231 CYS D N   1 
ATOM   8319 C  CA  . CYS D 1 231 ? 10.542  11.765  -51.973 1.00 12.18 ? 231 CYS D CA  1 
ATOM   8320 C  C   . CYS D 1 231 ? 10.367  13.135  -52.592 1.00 10.65 ? 231 CYS D C   1 
ATOM   8321 O  O   . CYS D 1 231 ? 10.042  14.072  -51.864 1.00 13.93 ? 231 CYS D O   1 
ATOM   8322 C  CB  . CYS D 1 231 ? 11.886  11.936  -51.226 1.00 12.96 ? 231 CYS D CB  1 
ATOM   8323 S  SG  . CYS D 1 231 ? 12.402  10.375  -50.414 1.00 15.77 ? 231 CYS D SG  1 
ATOM   8324 N  N   . THR D 1 232 ? 10.594  13.230  -53.867 1.00 10.63 ? 232 THR D N   1 
ATOM   8325 C  CA  . THR D 1 232 ? 10.591  14.520  -54.582 1.00 10.90 ? 232 THR D CA  1 
ATOM   8326 C  C   . THR D 1 232 ? 9.326   14.766  -55.358 1.00 11.94 ? 232 THR D C   1 
ATOM   8327 O  O   . THR D 1 232 ? 8.496   13.901  -55.697 1.00 10.45 ? 232 THR D O   1 
ATOM   8328 C  CB  . THR D 1 232 ? 11.779  14.516  -55.526 1.00 12.85 ? 232 THR D CB  1 
ATOM   8329 O  OG1 . THR D 1 232 ? 11.939  13.212  -56.118 1.00 12.87 ? 232 THR D OG1 1 
ATOM   8330 C  CG2 . THR D 1 232 ? 13.060  14.872  -54.791 1.00 13.44 ? 232 THR D CG2 1 
ATOM   8331 N  N   . HIS D 1 233 ? 9.143   16.053  -55.684 1.00 11.44 ? 233 HIS D N   1 
ATOM   8332 C  CA  . HIS D 1 233 ? 8.042   16.428  -56.537 1.00 12.67 ? 233 HIS D CA  1 
ATOM   8333 C  C   . HIS D 1 233 ? 8.257   15.892  -57.936 1.00 13.67 ? 233 HIS D C   1 
ATOM   8334 O  O   . HIS D 1 233 ? 9.406   15.609  -58.369 1.00 12.59 ? 233 HIS D O   1 
ATOM   8335 C  CB  . HIS D 1 233 ? 7.939   17.984  -56.626 1.00 15.49 ? 233 HIS D CB  1 
ATOM   8336 C  CG  . HIS D 1 233 ? 7.380   18.637  -55.423 1.00 17.00 ? 233 HIS D CG  1 
ATOM   8337 N  ND1 . HIS D 1 233 ? 8.070   19.545  -54.710 1.00 26.55 ? 233 HIS D ND1 1 
ATOM   8338 C  CD2 . HIS D 1 233 ? 6.103   18.554  -54.839 1.00 19.66 ? 233 HIS D CD2 1 
ATOM   8339 C  CE1 . HIS D 1 233 ? 7.286   20.016  -53.708 1.00 24.54 ? 233 HIS D CE1 1 
ATOM   8340 N  NE2 . HIS D 1 233 ? 6.088   19.393  -53.780 1.00 25.16 ? 233 HIS D NE2 1 
ATOM   8341 N  N   . MET D 1 234 ? 7.152   15.655  -58.618 1.00 15.13 ? 234 MET D N   1 
ATOM   8342 C  CA  . MET D 1 234 ? 7.244   15.120  -59.966 1.00 16.96 ? 234 MET D CA  1 
ATOM   8343 C  C   . MET D 1 234 ? 8.198   15.866  -60.934 1.00 20.29 ? 234 MET D C   1 
ATOM   8344 O  O   . MET D 1 234 ? 8.925   15.237  -61.718 1.00 19.65 ? 234 MET D O   1 
ATOM   8345 C  CB  . MET D 1 234 ? 5.824   15.036  -60.546 1.00 19.80 ? 234 MET D CB  1 
ATOM   8346 C  CG  . MET D 1 234 ? 5.832   14.252  -61.865 1.00 24.79 ? 234 MET D CG  1 
ATOM   8347 S  SD  . MET D 1 234 ? 4.116   14.205  -62.418 1.00 31.10 ? 234 MET D SD  1 
ATOM   8348 C  CE  . MET D 1 234 ? 4.160   13.184  -63.898 1.00 28.44 ? 234 MET D CE  1 
ATOM   8349 N  N   . ASP D 1 235 ? 8.266   17.179  -60.813 1.00 19.38 ? 235 ASP D N   1 
ATOM   8350 C  CA  . ASP D 1 235 ? 9.154   17.948  -61.686 1.00 23.99 ? 235 ASP D CA  1 
ATOM   8351 C  C   . ASP D 1 235 ? 10.561  18.229  -61.157 1.00 23.13 ? 235 ASP D C   1 
ATOM   8352 O  O   . ASP D 1 235 ? 11.302  18.965  -61.763 1.00 24.71 ? 235 ASP D O   1 
ATOM   8353 C  CB  . ASP D 1 235 ? 8.446   19.264  -62.021 1.00 29.59 ? 235 ASP D CB  1 
ATOM   8354 C  CG  . ASP D 1 235 ? 8.271   20.183  -60.780 1.00 34.28 ? 235 ASP D CG  1 
ATOM   8355 O  OD1 . ASP D 1 235 ? 8.612   19.792  -59.637 1.00 36.74 ? 235 ASP D OD1 1 
ATOM   8356 O  OD2 . ASP D 1 235 ? 7.791   21.320  -60.936 1.00 37.32 ? 235 ASP D OD2 1 
ATOM   8357 N  N   . ASP D 1 236 ? 10.989  17.630  -60.058 1.00 18.39 ? 236 ASP D N   1 
ATOM   8358 C  CA  . ASP D 1 236 ? 12.268  17.932  -59.501 1.00 19.92 ? 236 ASP D CA  1 
ATOM   8359 C  C   . ASP D 1 236 ? 13.349  17.397  -60.452 1.00 20.88 ? 236 ASP D C   1 
ATOM   8360 O  O   . ASP D 1 236 ? 13.305  16.259  -60.892 1.00 21.36 ? 236 ASP D O   1 
ATOM   8361 C  CB  . ASP D 1 236 ? 12.465  17.214  -58.117 1.00 18.30 ? 236 ASP D CB  1 
ATOM   8362 C  CG  . ASP D 1 236 ? 13.619  17.763  -57.340 1.00 21.88 ? 236 ASP D CG  1 
ATOM   8363 O  OD1 . ASP D 1 236 ? 14.740  17.914  -57.880 1.00 21.23 ? 236 ASP D OD1 1 
ATOM   8364 O  OD2 . ASP D 1 236 ? 13.426  18.028  -56.127 1.00 24.65 ? 236 ASP D OD2 1 
ATOM   8365 N  N   . PRO D 1 237 ? 14.357  18.217  -60.752 1.00 20.95 ? 237 PRO D N   1 
ATOM   8366 C  CA  . PRO D 1 237 ? 15.379  17.724  -61.664 1.00 20.59 ? 237 PRO D CA  1 
ATOM   8367 C  C   . PRO D 1 237 ? 16.389  16.771  -61.000 1.00 24.47 ? 237 PRO D C   1 
ATOM   8368 O  O   . PRO D 1 237 ? 17.199  16.151  -61.714 1.00 23.15 ? 237 PRO D O   1 
ATOM   8369 C  CB  . PRO D 1 237 ? 16.078  19.051  -62.119 1.00 22.41 ? 237 PRO D CB  1 
ATOM   8370 C  CG  . PRO D 1 237 ? 15.800  20.035  -61.040 1.00 24.53 ? 237 PRO D CG  1 
ATOM   8371 C  CD  . PRO D 1 237 ? 14.428  19.680  -60.496 1.00 22.30 ? 237 PRO D CD  1 
ATOM   8372 N  N   . SER D 1 238 ? 16.332  16.627  -59.654 1.00 20.91 ? 238 SER D N   1 
ATOM   8373 C  CA  . SER D 1 238 ? 17.120  15.644  -58.908 1.00 20.85 ? 238 SER D CA  1 
ATOM   8374 C  C   . SER D 1 238 ? 16.199  14.668  -58.142 1.00 15.55 ? 238 SER D C   1 
ATOM   8375 O  O   . SER D 1 238 ? 16.048  14.849  -56.983 1.00 19.00 ? 238 SER D O   1 
ATOM   8376 C  CB  . SER D 1 238 ? 18.003  16.311  -57.838 1.00 23.62 ? 238 SER D CB  1 
ATOM   8377 O  OG  . SER D 1 238 ? 18.950  17.215  -58.466 1.00 31.53 ? 238 SER D OG  1 
ATOM   8378 N  N   . PRO D 1 239 ? 15.603  13.736  -58.847 1.00 16.42 ? 239 PRO D N   1 
ATOM   8379 C  CA  . PRO D 1 239 ? 14.657  12.857  -58.109 1.00 16.69 ? 239 PRO D CA  1 
ATOM   8380 C  C   . PRO D 1 239 ? 15.334  11.978  -57.133 1.00 16.64 ? 239 PRO D C   1 
ATOM   8381 O  O   . PRO D 1 239 ? 16.520  11.566  -57.277 1.00 17.03 ? 239 PRO D O   1 
ATOM   8382 C  CB  . PRO D 1 239 ? 14.037  11.978  -59.170 1.00 17.00 ? 239 PRO D CB  1 
ATOM   8383 C  CG  . PRO D 1 239 ? 14.742  12.253  -60.439 1.00 19.19 ? 239 PRO D CG  1 
ATOM   8384 C  CD  . PRO D 1 239 ? 15.552  13.498  -60.268 1.00 17.18 ? 239 PRO D CD  1 
ATOM   8385 N  N   . ARG D 1 240 ? 14.554  11.687  -56.076 1.00 13.51 ? 240 ARG D N   1 
ATOM   8386 C  CA  . ARG D 1 240 ? 15.134  10.760  -55.060 1.00 12.24 ? 240 ARG D CA  1 
ATOM   8387 C  C   . ARG D 1 240 ? 14.069  9.704   -54.709 1.00 11.85 ? 240 ARG D C   1 
ATOM   8388 O  O   . ARG D 1 240 ? 12.959  10.075  -54.336 1.00 11.98 ? 240 ARG D O   1 
ATOM   8389 C  CB  . ARG D 1 240 ? 15.403  11.522  -53.797 1.00 13.31 ? 240 ARG D CB  1 
ATOM   8390 C  CG  . ARG D 1 240 ? 16.642  12.456  -53.917 1.00 17.66 ? 240 ARG D CG  1 
ATOM   8391 C  CD  . ARG D 1 240 ? 16.968  13.202  -52.629 1.00 20.05 ? 240 ARG D CD  1 
ATOM   8392 N  NE  . ARG D 1 240 ? 15.980  14.229  -52.352 1.00 22.80 ? 240 ARG D NE  1 
ATOM   8393 C  CZ  . ARG D 1 240 ? 15.067  14.136  -51.372 1.00 24.02 ? 240 ARG D CZ  1 
ATOM   8394 N  NH1 . ARG D 1 240 ? 15.042  13.068  -50.551 1.00 19.00 ? 240 ARG D NH1 1 
ATOM   8395 N  NH2 . ARG D 1 240 ? 14.179  15.101  -51.211 1.00 26.17 ? 240 ARG D NH2 1 
ATOM   8396 N  N   . GLU D 1 241 ? 14.408  8.436   -54.894 1.00 12.16 ? 241 GLU D N   1 
ATOM   8397 C  CA  . GLU D 1 241 ? 13.522  7.325   -54.488 1.00 12.15 ? 241 GLU D CA  1 
ATOM   8398 C  C   . GLU D 1 241 ? 13.303  7.295   -52.974 1.00 9.71  ? 241 GLU D C   1 
ATOM   8399 O  O   . GLU D 1 241 ? 14.221  7.504   -52.162 1.00 10.89 ? 241 GLU D O   1 
ATOM   8400 C  CB  . GLU D 1 241 ? 14.169  6.009   -54.883 1.00 14.49 ? 241 GLU D CB  1 
ATOM   8401 C  CG  . GLU D 1 241 ? 14.260  5.860   -56.402 1.00 19.42 ? 241 GLU D CG  1 
ATOM   8402 C  CD  . GLU D 1 241 ? 15.259  4.815   -56.829 1.00 23.10 ? 241 GLU D CD  1 
ATOM   8403 O  OE1 . GLU D 1 241 ? 16.480  4.866   -56.387 1.00 32.15 ? 241 GLU D OE1 1 
ATOM   8404 O  OE2 . GLU D 1 241 ? 14.846  4.020   -57.680 1.00 31.28 ? 241 GLU D OE2 1 
ATOM   8405 N  N   . MET D 1 242 ? 12.048  6.990   -52.604 1.00 8.44  ? 242 MET D N   1 
ATOM   8406 C  CA  . MET D 1 242 ? 11.696  6.757   -51.229 1.00 8.87  ? 242 MET D CA  1 
ATOM   8407 C  C   . MET D 1 242 ? 11.987  5.305   -50.857 1.00 7.94  ? 242 MET D C   1 
ATOM   8408 O  O   . MET D 1 242 ? 11.146  4.404   -51.055 1.00 7.52  ? 242 MET D O   1 
ATOM   8409 C  CB  . MET D 1 242 ? 10.233  7.223   -51.026 1.00 8.26  ? 242 MET D CB  1 
ATOM   8410 C  CG  . MET D 1 242 ? 9.869   7.196   -49.544 1.00 8.19  ? 242 MET D CG  1 
ATOM   8411 S  SD  . MET D 1 242 ? 8.161   7.525   -49.247 1.00 10.23 ? 242 MET D SD  1 
ATOM   8412 C  CE  . MET D 1 242 ? 8.051   9.206   -49.886 1.00 12.15 ? 242 MET D CE  1 
ATOM   8413 N  N   . ILE D 1 243 ? 13.201  5.116   -50.383 1.00 7.93  ? 243 ILE D N   1 
ATOM   8414 C  CA  . ILE D 1 243 ? 13.769  3.789   -50.045 1.00 7.91  ? 243 ILE D CA  1 
ATOM   8415 C  C   . ILE D 1 243 ? 14.542  4.001   -48.773 1.00 6.77  ? 243 ILE D C   1 
ATOM   8416 O  O   . ILE D 1 243 ? 14.961  5.088   -48.442 1.00 7.10  ? 243 ILE D O   1 
ATOM   8417 C  CB  . ILE D 1 243 ? 14.694  3.182   -51.111 1.00 8.45  ? 243 ILE D CB  1 
ATOM   8418 C  CG1 . ILE D 1 243 ? 15.782  4.219   -51.495 1.00 9.76  ? 243 ILE D CG1 1 
ATOM   8419 C  CG2 . ILE D 1 243 ? 13.879  2.782   -52.305 1.00 11.03 ? 243 ILE D CG2 1 
ATOM   8420 C  CD1 . ILE D 1 243 ? 16.868  3.662   -52.384 1.00 11.51 ? 243 ILE D CD1 1 
ATOM   8421 N  N   . ASN D 1 244 ? 14.696  2.886   -48.036 1.00 6.18  ? 244 ASN D N   1 
ATOM   8422 C  CA  . ASN D 1 244 ? 15.483  2.889   -46.826 1.00 6.06  ? 244 ASN D CA  1 
ATOM   8423 C  C   . ASN D 1 244 ? 15.079  3.970   -45.849 1.00 6.38  ? 244 ASN D C   1 
ATOM   8424 O  O   . ASN D 1 244 ? 15.914  4.614   -45.237 1.00 6.58  ? 244 ASN D O   1 
ATOM   8425 C  CB  . ASN D 1 244 ? 17.011  2.977   -47.144 1.00 6.63  ? 244 ASN D CB  1 
ATOM   8426 C  CG  . ASN D 1 244 ? 17.429  1.930   -48.096 1.00 8.90  ? 244 ASN D CG  1 
ATOM   8427 O  OD1 . ASN D 1 244 ? 17.016  0.742   -47.983 1.00 10.48 ? 244 ASN D OD1 1 
ATOM   8428 N  ND2 . ASN D 1 244 ? 18.134  2.398   -49.152 1.00 11.18 ? 244 ASN D ND2 1 
ATOM   8429 N  N   . ASN D 1 245 ? 13.778  4.112   -45.701 1.00 5.59  ? 245 ASN D N   1 
ATOM   8430 C  CA  . ASN D 1 245 ? 13.251  5.221   -44.892 1.00 5.07  ? 245 ASN D CA  1 
ATOM   8431 C  C   . ASN D 1 245 ? 12.980  4.765   -43.501 1.00 5.28  ? 245 ASN D C   1 
ATOM   8432 O  O   . ASN D 1 245 ? 11.867  4.782   -42.966 1.00 6.26  ? 245 ASN D O   1 
ATOM   8433 C  CB  . ASN D 1 245 ? 11.947  5.776   -45.570 1.00 5.38  ? 245 ASN D CB  1 
ATOM   8434 C  CG  . ASN D 1 245 ? 10.819  4.757   -45.662 1.00 5.72  ? 245 ASN D CG  1 
ATOM   8435 O  OD1 . ASN D 1 245 ? 11.011  3.575   -45.772 1.00 6.57  ? 245 ASN D OD1 1 
ATOM   8436 N  ND2 . ASN D 1 245 ? 9.573   5.240   -45.717 1.00 8.17  ? 245 ASN D ND2 1 
ATOM   8437 N  N   . PHE D 1 246 ? 14.004  4.254   -42.882 1.00 4.94  ? 246 PHE D N   1 
ATOM   8438 C  CA  . PHE D 1 246 ? 14.022  3.846   -41.470 1.00 4.99  ? 246 PHE D CA  1 
ATOM   8439 C  C   . PHE D 1 246 ? 15.201  4.488   -40.785 1.00 5.62  ? 246 PHE D C   1 
ATOM   8440 O  O   . PHE D 1 246 ? 16.313  4.632   -41.381 1.00 5.66  ? 246 PHE D O   1 
ATOM   8441 C  CB  . PHE D 1 246 ? 14.065  2.278   -41.368 1.00 5.86  ? 246 PHE D CB  1 
ATOM   8442 C  CG  . PHE D 1 246 ? 15.310  1.620   -41.929 1.00 5.96  ? 246 PHE D CG  1 
ATOM   8443 C  CD1 . PHE D 1 246 ? 16.421  1.276   -41.101 1.00 6.76  ? 246 PHE D CD1 1 
ATOM   8444 C  CD2 . PHE D 1 246 ? 15.332  1.262   -43.302 1.00 5.66  ? 246 PHE D CD2 1 
ATOM   8445 C  CE1 . PHE D 1 246 ? 17.537  0.713   -41.702 1.00 7.58  ? 246 PHE D CE1 1 
ATOM   8446 C  CE2 . PHE D 1 246 ? 16.430  0.691   -43.907 1.00 6.53  ? 246 PHE D CE2 1 
ATOM   8447 C  CZ  . PHE D 1 246 ? 17.554  0.441   -43.085 1.00 7.35  ? 246 PHE D CZ  1 
ATOM   8448 N  N   . ARG D 1 247 ? 15.009  4.792   -39.529 1.00 4.77  ? 247 ARG D N   1 
ATOM   8449 C  CA  . ARG D 1 247 ? 16.116  5.316   -38.681 1.00 4.78  ? 247 ARG D CA  1 
ATOM   8450 C  C   . ARG D 1 247 ? 16.834  4.114   -38.047 1.00 4.81  ? 247 ARG D C   1 
ATOM   8451 O  O   . ARG D 1 247 ? 16.202  3.074   -37.701 1.00 4.89  ? 247 ARG D O   1 
ATOM   8452 C  CB  . ARG D 1 247 ? 15.491  6.192   -37.555 1.00 4.62  ? 247 ARG D CB  1 
ATOM   8453 C  CG  . ARG D 1 247 ? 16.535  7.005   -36.821 1.00 4.92  ? 247 ARG D CG  1 
ATOM   8454 C  CD  . ARG D 1 247 ? 15.877  7.703   -35.692 1.00 5.94  ? 247 ARG D CD  1 
ATOM   8455 N  NE  . ARG D 1 247 ? 16.691  8.800   -35.166 1.00 5.34  ? 247 ARG D NE  1 
ATOM   8456 C  CZ  . ARG D 1 247 ? 16.411  9.492   -34.064 1.00 5.51  ? 247 ARG D CZ  1 
ATOM   8457 N  NH1 . ARG D 1 247 ? 15.328  9.213   -33.349 1.00 5.73  ? 247 ARG D NH1 1 
ATOM   8458 N  NH2 . ARG D 1 247 ? 17.220  10.468  -33.674 1.00 4.71  ? 247 ARG D NH2 1 
ATOM   8459 N  N   . GLN D 1 248 ? 18.168  4.225   -37.856 1.00 4.53  ? 248 GLN D N   1 
ATOM   8460 C  CA  . GLN D 1 248 ? 18.915  3.183   -37.066 1.00 4.92  ? 248 GLN D CA  1 
ATOM   8461 C  C   . GLN D 1 248 ? 18.418  3.121   -35.658 1.00 5.27  ? 248 GLN D C   1 
ATOM   8462 O  O   . GLN D 1 248 ? 17.896  4.125   -35.101 1.00 5.47  ? 248 GLN D O   1 
ATOM   8463 C  CB  . GLN D 1 248 ? 20.415  3.527   -37.035 1.00 5.03  ? 248 GLN D CB  1 
ATOM   8464 C  CG  . GLN D 1 248 ? 21.050  3.547   -38.415 1.00 6.33  ? 248 GLN D CG  1 
ATOM   8465 C  CD  . GLN D 1 248 ? 21.091  2.181   -39.043 1.00 7.62  ? 248 GLN D CD  1 
ATOM   8466 O  OE1 . GLN D 1 248 ? 20.181  1.824   -39.800 1.00 8.34  ? 248 GLN D OE1 1 
ATOM   8467 N  NE2 . GLN D 1 248 ? 22.109  1.384   -38.747 1.00 8.21  ? 248 GLN D NE2 1 
ATOM   8468 N  N   . VAL D 1 249 ? 18.629  1.960   -35.047 1.00 5.39  ? 249 VAL D N   1 
ATOM   8469 C  CA  . VAL D 1 249 ? 18.238  1.886   -33.624 1.00 5.31  ? 249 VAL D CA  1 
ATOM   8470 C  C   . VAL D 1 249 ? 19.122  2.768   -32.703 1.00 5.50  ? 249 VAL D C   1 
ATOM   8471 O  O   . VAL D 1 249 ? 20.289  3.073   -33.054 1.00 5.66  ? 249 VAL D O   1 
ATOM   8472 C  CB  . VAL D 1 249 ? 18.262  0.438   -33.123 1.00 5.63  ? 249 VAL D CB  1 
ATOM   8473 C  CG1 . VAL D 1 249 ? 17.203  -0.431  -33.790 1.00 7.21  ? 249 VAL D CG1 1 
ATOM   8474 C  CG2 . VAL D 1 249 ? 19.633  -0.199  -33.305 1.00 6.84  ? 249 VAL D CG2 1 
ATOM   8475 N  N   . GLN D 1 250 ? 18.543  3.165   -31.640 1.00 5.35  ? 250 GLN D N   1 
ATOM   8476 C  CA  . GLN D 1 250 ? 19.131  4.134   -30.700 1.00 5.65  ? 250 GLN D CA  1 
ATOM   8477 C  C   . GLN D 1 250 ? 19.656  3.549   -29.422 1.00 6.97  ? 250 GLN D C   1 
ATOM   8478 O  O   . GLN D 1 250 ? 19.159  2.472   -29.000 1.00 7.68  ? 250 GLN D O   1 
ATOM   8479 C  CB  . GLN D 1 250 ? 17.983  5.137   -30.334 1.00 5.71  ? 250 GLN D CB  1 
ATOM   8480 C  CG  . GLN D 1 250 ? 17.350  5.814   -31.581 1.00 6.31  ? 250 GLN D CG  1 
ATOM   8481 C  CD  . GLN D 1 250 ? 18.288  6.689   -32.350 1.00 5.82  ? 250 GLN D CD  1 
ATOM   8482 O  OE1 . GLN D 1 250 ? 18.762  7.718   -31.767 1.00 6.54  ? 250 GLN D OE1 1 
ATOM   8483 N  NE2 . GLN D 1 250 ? 18.536  6.432   -33.624 1.00 5.85  ? 250 GLN D NE2 1 
ATOM   8484 N  N   . LYS D 1 251 ? 20.527  4.274   -28.753 1.00 7.35  ? 251 LYS D N   1 
ATOM   8485 C  CA  . LYS D 1 251 ? 20.948  3.846   -27.403 1.00 8.78  ? 251 LYS D CA  1 
ATOM   8486 C  C   . LYS D 1 251 ? 19.717  3.773   -26.493 1.00 8.88  ? 251 LYS D C   1 
ATOM   8487 O  O   . LYS D 1 251 ? 18.801  4.591   -26.593 1.00 8.77  ? 251 LYS D O   1 
ATOM   8488 C  CB  . LYS D 1 251 ? 21.827  4.962   -26.872 1.00 10.02 ? 251 LYS D CB  1 
ATOM   8489 C  CG  . LYS D 1 251 ? 23.228  4.995   -27.501 1.00 11.82 ? 251 LYS D CG  1 
ATOM   8490 C  CD  . LYS D 1 251 ? 24.061  3.866   -26.955 1.00 11.24 ? 251 LYS D CD  1 
ATOM   8491 C  CE  . LYS D 1 251 ? 25.550  3.877   -27.329 1.00 11.29 ? 251 LYS D CE  1 
ATOM   8492 N  NZ  . LYS D 1 251 ? 25.702  3.780   -28.849 1.00 10.49 ? 251 LYS D NZ  1 
ATOM   8493 N  N   A PHE D 1 252 ? 19.666  2.771   -25.672 0.50 11.21 ? 252 PHE D N   1 
ATOM   8494 N  N   B PHE D 1 252 ? 19.730  2.810   -25.560 0.50 9.48  ? 252 PHE D N   1 
ATOM   8495 C  CA  A PHE D 1 252 ? 18.524  2.730   -24.805 0.50 12.98 ? 252 PHE D CA  1 
ATOM   8496 C  CA  B PHE D 1 252 ? 18.661  2.631   -24.597 0.50 9.93  ? 252 PHE D CA  1 
ATOM   8497 C  C   A PHE D 1 252 ? 19.024  3.215   -23.403 0.50 17.91 ? 252 PHE D C   1 
ATOM   8498 C  C   B PHE D 1 252 ? 18.620  3.593   -23.470 0.50 12.69 ? 252 PHE D C   1 
ATOM   8499 O  O   A PHE D 1 252 ? 19.243  2.431   -22.484 0.50 17.38 ? 252 PHE D O   1 
ATOM   8500 O  O   B PHE D 1 252 ? 17.560  4.106   -23.029 0.50 10.33 ? 252 PHE D O   1 
ATOM   8501 C  CB  A PHE D 1 252 ? 17.844  1.359   -24.941 0.50 13.85 ? 252 PHE D CB  1 
ATOM   8502 C  CB  B PHE D 1 252 ? 18.814  1.243   -23.952 0.50 9.10  ? 252 PHE D CB  1 
ATOM   8503 C  CG  A PHE D 1 252 ? 16.419  1.300   -24.465 0.50 12.31 ? 252 PHE D CG  1 
ATOM   8504 C  CG  B PHE D 1 252 ? 18.157  0.204   -24.758 0.50 10.03 ? 252 PHE D CG  1 
ATOM   8505 C  CD1 A PHE D 1 252 ? 16.035  0.276   -23.626 0.50 12.84 ? 252 PHE D CD1 1 
ATOM   8506 C  CD1 B PHE D 1 252 ? 16.854  -0.104  -24.480 0.50 11.00 ? 252 PHE D CD1 1 
ATOM   8507 C  CD2 A PHE D 1 252 ? 15.456  2.243   -24.848 0.50 11.92 ? 252 PHE D CD2 1 
ATOM   8508 C  CD2 B PHE D 1 252 ? 18.771  -0.322  -25.898 0.50 10.54 ? 252 PHE D CD2 1 
ATOM   8509 C  CE1 A PHE D 1 252 ? 14.765  0.196   -23.123 0.50 12.87 ? 252 PHE D CE1 1 
ATOM   8510 C  CE1 B PHE D 1 252 ? 16.163  -0.988  -25.270 0.50 12.45 ? 252 PHE D CE1 1 
ATOM   8511 C  CE2 A PHE D 1 252 ? 14.168  2.165   -24.342 0.50 13.51 ? 252 PHE D CE2 1 
ATOM   8512 C  CE2 B PHE D 1 252 ? 18.092  -1.228  -26.679 0.50 9.65  ? 252 PHE D CE2 1 
ATOM   8513 C  CZ  A PHE D 1 252 ? 13.821  1.128   -23.493 0.50 11.78 ? 252 PHE D CZ  1 
ATOM   8514 C  CZ  B PHE D 1 252 ? 16.771  -1.547  -26.379 0.50 10.82 ? 252 PHE D CZ  1 
ATOM   8515 N  N   A ASP D 1 253 ? 19.251  4.548   -23.377 0.50 15.62 ? 253 ASP D N   1 
ATOM   8516 N  N   B ASP D 1 253 ? 19.804  3.673   -22.907 0.50 16.27 ? 253 ASP D N   1 
ATOM   8517 C  CA  A ASP D 1 253 ? 19.433  5.460   -22.223 0.50 16.29 ? 253 ASP D CA  1 
ATOM   8518 C  CA  B ASP D 1 253 ? 20.208  2.989   -21.751 0.50 19.51 ? 253 ASP D CA  1 
ATOM   8519 C  C   A ASP D 1 253 ? 18.786  4.959   -20.856 0.50 16.55 ? 253 ASP D C   1 
ATOM   8520 C  C   B ASP D 1 253 ? 19.483  3.572   -20.545 0.50 19.78 ? 253 ASP D C   1 
ATOM   8521 O  O   A ASP D 1 253 ? 17.997  5.693   -20.239 0.50 17.07 ? 253 ASP D O   1 
ATOM   8522 O  O   B ASP D 1 253 ? 18.880  4.629   -20.659 0.50 24.50 ? 253 ASP D O   1 
ATOM   8523 C  CB  A ASP D 1 253 ? 18.707  6.800   -22.548 0.50 15.56 ? 253 ASP D CB  1 
ATOM   8524 C  CB  B ASP D 1 253 ? 21.679  2.694   -21.626 0.50 19.12 ? 253 ASP D CB  1 
ATOM   8525 C  CG  A ASP D 1 253 ? 19.338  7.535   -23.782 0.50 16.20 ? 253 ASP D CG  1 
ATOM   8526 C  CG  B ASP D 1 253 ? 22.388  2.966   -23.007 0.50 19.10 ? 253 ASP D CG  1 
ATOM   8527 O  OD1 A ASP D 1 253 ? 20.559  7.483   -23.951 0.50 17.67 ? 253 ASP D OD1 1 
ATOM   8528 O  OD1 B ASP D 1 253 ? 23.198  2.233   -23.531 0.50 22.44 ? 253 ASP D OD1 1 
ATOM   8529 O  OD2 A ASP D 1 253 ? 18.584  8.168   -24.558 0.50 15.42 ? 253 ASP D OD2 1 
ATOM   8530 O  OD2 B ASP D 1 253 ? 22.119  3.987   -23.581 0.50 18.71 ? 253 ASP D OD2 1 
ATOM   8531 N  N   A GLU D 1 254 ? 19.169  3.725   -20.429 0.50 15.40 ? 254 GLU D N   1 
ATOM   8532 N  N   B GLU D 1 254 ? 19.437  2.884   -19.421 0.50 23.45 ? 254 GLU D N   1 
ATOM   8533 C  CA  A GLU D 1 254 ? 18.792  3.111   -19.129 0.50 17.85 ? 254 GLU D CA  1 
ATOM   8534 C  CA  B GLU D 1 254 ? 18.447  3.391   -18.471 0.50 25.81 ? 254 GLU D CA  1 
ATOM   8535 C  C   A GLU D 1 254 ? 17.398  2.486   -19.164 0.50 18.57 ? 254 GLU D C   1 
ATOM   8536 C  C   B GLU D 1 254 ? 17.059  2.871   -18.836 0.50 22.31 ? 254 GLU D C   1 
ATOM   8537 O  O   A GLU D 1 254 ? 17.051  1.631   -18.363 0.50 17.82 ? 254 GLU D O   1 
ATOM   8538 O  O   B GLU D 1 254 ? 16.371  2.437   -17.912 0.50 20.15 ? 254 GLU D O   1 
ATOM   8539 C  CB  A GLU D 1 254 ? 18.901  4.101   -17.936 0.50 18.84 ? 254 GLU D CB  1 
ATOM   8540 C  CB  B GLU D 1 254 ? 18.347  4.946   -18.402 0.50 29.26 ? 254 GLU D CB  1 
ATOM   8541 C  CG  A GLU D 1 254 ? 20.255  4.714   -17.771 0.50 20.15 ? 254 GLU D CG  1 
ATOM   8542 C  CG  B GLU D 1 254 ? 19.602  5.750   -18.035 0.50 31.80 ? 254 GLU D CG  1 
ATOM   8543 C  CD  A GLU D 1 254 ? 21.324  3.697   -17.534 0.50 22.00 ? 254 GLU D CD  1 
ATOM   8544 C  CD  B GLU D 1 254 ? 20.728  4.909   -17.460 0.50 35.33 ? 254 GLU D CD  1 
ATOM   8545 O  OE1 A GLU D 1 254 ? 22.365  3.731   -18.260 0.50 24.34 ? 254 GLU D OE1 1 
ATOM   8546 O  OE1 B GLU D 1 254 ? 21.841  4.952   -18.046 0.50 34.58 ? 254 GLU D OE1 1 
ATOM   8547 O  OE2 A GLU D 1 254 ? 21.109  2.861   -16.630 0.50 23.58 ? 254 GLU D OE2 1 
ATOM   8548 O  OE2 B GLU D 1 254 ? 20.505  4.223   -16.434 0.50 36.14 ? 254 GLU D OE2 1 
ATOM   8549 N  N   . ARG D 1 255 ? 16.605  2.913   -20.125 1.00 18.88 ? 255 ARG D N   1 
ATOM   8550 C  CA  . ARG D 1 255 ? 15.251  2.393   -20.328 1.00 17.40 ? 255 ARG D CA  1 
ATOM   8551 C  C   . ARG D 1 255 ? 15.128  0.819   -20.352 1.00 19.32 ? 255 ARG D C   1 
ATOM   8552 O  O   . ARG D 1 255 ? 16.094  0.126   -20.799 1.00 21.40 ? 255 ARG D O   1 
ATOM   8553 C  CB  . ARG D 1 255 ? 14.636  2.985   -21.626 1.00 18.21 ? 255 ARG D CB  1 
ATOM   8554 C  CG  . ARG D 1 255 ? 14.432  4.508   -21.703 1.00 18.71 ? 255 ARG D CG  1 
ATOM   8555 C  CD  . ARG D 1 255 ? 13.800  4.754   -23.115 1.00 19.72 ? 255 ARG D CD  1 
ATOM   8556 N  NE  . ARG D 1 255 ? 14.847  4.748   -24.144 1.00 20.12 ? 255 ARG D NE  1 
ATOM   8557 C  CZ  . ARG D 1 255 ? 14.712  5.050   -25.431 1.00 17.71 ? 255 ARG D CZ  1 
ATOM   8558 N  NH1 . ARG D 1 255 ? 13.471  5.309   -25.894 1.00 11.81 ? 255 ARG D NH1 1 
ATOM   8559 N  NH2 . ARG D 1 255 ? 15.839  5.099   -26.230 1.00 14.44 ? 255 ARG D NH2 1 
ATOM   8560 N  N   . LEU D 1 256 ? 14.020  0.263   -19.811 1.00 17.45 ? 256 LEU D N   1 
ATOM   8561 C  CA  . LEU D 1 256 ? 13.611  -1.128  -20.031 1.00 14.46 ? 256 LEU D CA  1 
ATOM   8562 C  C   . LEU D 1 256 ? 12.432  -1.088  -20.987 1.00 13.07 ? 256 LEU D C   1 
ATOM   8563 O  O   . LEU D 1 256 ? 11.755  -0.042  -21.144 1.00 14.80 ? 256 LEU D O   1 
ATOM   8564 C  CB  . LEU D 1 256 ? 13.115  -1.748  -18.760 1.00 16.33 ? 256 LEU D CB  1 
ATOM   8565 C  CG  . LEU D 1 256 ? 14.210  -1.743  -17.726 1.00 16.37 ? 256 LEU D CG  1 
ATOM   8566 C  CD1 . LEU D 1 256 ? 13.641  -2.453  -16.496 1.00 21.13 ? 256 LEU D CD1 1 
ATOM   8567 C  CD2 . LEU D 1 256 ? 15.548  -2.361  -18.213 1.00 20.08 ? 256 LEU D CD2 1 
ATOM   8568 N  N   . VAL D 1 257 ? 12.238  -2.182  -21.677 1.00 12.29 ? 257 VAL D N   1 
ATOM   8569 C  CA  . VAL D 1 257 ? 11.045  -2.403  -22.492 1.00 10.57 ? 257 VAL D CA  1 
ATOM   8570 C  C   . VAL D 1 257 ? 10.212  -3.404  -21.735 1.00 10.95 ? 257 VAL D C   1 
ATOM   8571 O  O   . VAL D 1 257 ? 10.686  -4.451  -21.322 1.00 10.80 ? 257 VAL D O   1 
ATOM   8572 C  CB  . VAL D 1 257 ? 11.420  -3.022  -23.860 1.00 10.84 ? 257 VAL D CB  1 
ATOM   8573 C  CG1 . VAL D 1 257 ? 10.187  -3.410  -24.654 1.00 11.07 ? 257 VAL D CG1 1 
ATOM   8574 C  CG2 . VAL D 1 257 ? 12.240  -2.003  -24.679 1.00 11.29 ? 257 VAL D CG2 1 
ATOM   8575 N  N   . TYR D 1 258 ? 9.002   -3.049  -21.457 1.00 8.68  ? 258 TYR D N   1 
ATOM   8576 C  CA  . TYR D 1 258 ? 8.065   -3.861  -20.656 1.00 9.24  ? 258 TYR D CA  1 
ATOM   8577 C  C   . TYR D 1 258 ? 7.280   -4.751  -21.587 1.00 9.12  ? 258 TYR D C   1 
ATOM   8578 O  O   . TYR D 1 258 ? 6.966   -4.421  -22.771 1.00 9.86  ? 258 TYR D O   1 
ATOM   8579 C  CB  . TYR D 1 258 ? 7.166   -2.945  -19.824 1.00 10.25 ? 258 TYR D CB  1 
ATOM   8580 C  CG  . TYR D 1 258 ? 8.011   -2.089  -18.934 1.00 12.46 ? 258 TYR D CG  1 
ATOM   8581 C  CD1 . TYR D 1 258 ? 8.527   -2.623  -17.741 1.00 13.04 ? 258 TYR D CD1 1 
ATOM   8582 C  CD2 . TYR D 1 258 ? 8.434   -0.809  -19.348 1.00 11.87 ? 258 TYR D CD2 1 
ATOM   8583 C  CE1 . TYR D 1 258 ? 9.362   -1.843  -16.919 1.00 15.19 ? 258 TYR D CE1 1 
ATOM   8584 C  CE2 . TYR D 1 258 ? 9.229   -0.035  -18.537 1.00 15.02 ? 258 TYR D CE2 1 
ATOM   8585 C  CZ  . TYR D 1 258 ? 9.713   -0.571  -17.349 1.00 17.51 ? 258 TYR D CZ  1 
ATOM   8586 O  OH  . TYR D 1 258 ? 10.576  0.174   -16.554 1.00 21.02 ? 258 TYR D OH  1 
ATOM   8587 N  N   . THR D 1 259 ? 7.012   -5.985  -21.179 1.00 8.10  ? 259 THR D N   1 
ATOM   8588 C  CA  . THR D 1 259 ? 6.353   -6.917  -22.063 1.00 7.81  ? 259 THR D CA  1 
ATOM   8589 C  C   . THR D 1 259 ? 5.068   -7.407  -21.419 1.00 7.85  ? 259 THR D C   1 
ATOM   8590 O  O   . THR D 1 259 ? 5.024   -7.585  -20.178 1.00 8.50  ? 259 THR D O   1 
ATOM   8591 C  CB  . THR D 1 259 ? 7.188   -8.131  -22.443 1.00 8.45  ? 259 THR D CB  1 
ATOM   8592 O  OG1 . THR D 1 259 ? 7.671   -8.728  -21.268 1.00 9.83  ? 259 THR D OG1 1 
ATOM   8593 C  CG2 . THR D 1 259 ? 8.473   -7.687  -23.223 1.00 9.46  ? 259 THR D CG2 1 
ATOM   8594 N  N   . SER D 1 260 ? 4.112   -7.736  -22.215 1.00 8.70  ? 260 SER D N   1 
ATOM   8595 C  CA  . SER D 1 260 ? 2.828   -8.254  -21.675 1.00 8.53  ? 260 SER D CA  1 
ATOM   8596 C  C   . SER D 1 260 ? 2.910   -9.778  -21.670 1.00 10.31 ? 260 SER D C   1 
ATOM   8597 O  O   . SER D 1 260 ? 1.879   -10.442 -21.306 1.00 15.23 ? 260 SER D O   1 
ATOM   8598 C  CB  . SER D 1 260 ? 1.678   -7.742  -22.562 1.00 9.86  ? 260 SER D CB  1 
ATOM   8599 O  OG  . SER D 1 260 ? 1.803   -8.358  -23.839 1.00 9.81  ? 260 SER D OG  1 
ATOM   8600 N  N   . PHE D 1 261 ? 4.035   -10.389 -21.991 1.00 11.04 ? 261 PHE D N   1 
ATOM   8601 C  CA  . PHE D 1 261 ? 4.252   -11.840 -22.081 1.00 12.57 ? 261 PHE D CA  1 
ATOM   8602 C  C   . PHE D 1 261 ? 5.517   -12.198 -21.396 1.00 16.23 ? 261 PHE D C   1 
ATOM   8603 O  O   . PHE D 1 261 ? 6.420   -11.415 -21.277 1.00 14.07 ? 261 PHE D O   1 
ATOM   8604 C  CB  . PHE D 1 261 ? 4.271   -12.285 -23.538 1.00 12.60 ? 261 PHE D CB  1 
ATOM   8605 C  CG  . PHE D 1 261 ? 5.325   -11.585 -24.335 1.00 12.50 ? 261 PHE D CG  1 
ATOM   8606 C  CD1 . PHE D 1 261 ? 6.617   -12.153 -24.435 1.00 15.23 ? 261 PHE D CD1 1 
ATOM   8607 C  CD2 . PHE D 1 261 ? 5.091   -10.370 -25.007 1.00 12.73 ? 261 PHE D CD2 1 
ATOM   8608 C  CE1 . PHE D 1 261 ? 7.611   -11.567 -25.182 1.00 14.80 ? 261 PHE D CE1 1 
ATOM   8609 C  CE2 . PHE D 1 261 ? 6.127   -9.796  -25.752 1.00 12.92 ? 261 PHE D CE2 1 
ATOM   8610 C  CZ  . PHE D 1 261 ? 7.364   -10.355 -25.827 1.00 14.55 ? 261 PHE D CZ  1 
ATOM   8611 N  N   . SER D 1 262 ? 5.545   -13.455 -20.907 1.00 24.30 ? 262 SER D N   1 
ATOM   8612 C  CA  . SER D 1 262 ? 6.800   -14.155 -20.467 1.00 29.07 ? 262 SER D CA  1 
ATOM   8613 C  C   . SER D 1 262 ? 7.517   -14.971 -21.588 1.00 29.54 ? 262 SER D C   1 
ATOM   8614 O  O   . SER D 1 262 ? 6.988   -15.662 -22.462 1.00 32.65 ? 262 SER D O   1 
ATOM   8615 C  CB  . SER D 1 262 ? 6.573   -15.048 -19.220 1.00 38.11 ? 262 SER D CB  1 
ATOM   8616 O  OG  . SER D 1 262 ? 5.713   -14.456 -18.222 1.00 34.16 ? 262 SER D OG  1 
HETATM 8617 ZN ZN  . ZN  E 2 .   ? 22.888  0.440   12.277  1.00 6.72  ? 301 ZN  A ZN  1 
HETATM 8618 C  C3  A 6Z9 F 3 .   ? 24.121  3.775   11.491  0.50 12.62 ? 302 6Z9 A C3  1 
HETATM 8619 C  C3  B 6Z9 F 3 .   ? 24.121  3.763   11.486  0.50 13.98 ? 302 6Z9 A C3  1 
HETATM 8620 C  C4  A 6Z9 F 3 .   ? 23.552  3.931   12.747  0.50 14.01 ? 302 6Z9 A C4  1 
HETATM 8621 C  C4  B 6Z9 F 3 .   ? 23.563  3.891   12.749  0.50 15.42 ? 302 6Z9 A C4  1 
HETATM 8622 C  C8  A 6Z9 F 3 .   ? 25.075  5.756   13.333  0.50 17.54 ? 302 6Z9 A C8  1 
HETATM 8623 C  C8  B 6Z9 F 3 .   ? 25.095  5.680   13.349  0.50 20.15 ? 302 6Z9 A C8  1 
HETATM 8624 C  C6  A 6Z9 F 3 .   ? 24.000  4.892   13.648  0.50 15.53 ? 302 6Z9 A C6  1 
HETATM 8625 C  C6  B 6Z9 F 3 .   ? 24.030  4.819   13.665  0.50 17.31 ? 302 6Z9 A C6  1 
HETATM 8626 C  C11 A 6Z9 F 3 .   ? 25.719  6.322   16.224  0.50 21.11 ? 302 6Z9 A C11 1 
HETATM 8627 C  C11 B 6Z9 F 3 .   ? 24.325  7.693   15.761  0.50 27.16 ? 302 6Z9 A C11 1 
HETATM 8628 C  C12 A 6Z9 F 3 .   ? 26.796  5.258   16.136  0.50 21.78 ? 302 6Z9 A C12 1 
HETATM 8629 C  C12 B 6Z9 F 3 .   ? 23.941  9.032   15.154  0.50 25.94 ? 302 6Z9 A C12 1 
HETATM 8630 C  C15 A 6Z9 F 3 .   ? 25.689  5.559   12.108  0.50 17.06 ? 302 6Z9 A C15 1 
HETATM 8631 C  C15 B 6Z9 F 3 .   ? 25.721  5.508   12.118  0.50 18.08 ? 302 6Z9 A C15 1 
HETATM 8632 C  C17 A 6Z9 F 3 .   ? 26.594  7.276   10.495  0.50 26.10 ? 302 6Z9 A C17 1 
HETATM 8633 C  C17 B 6Z9 F 3 .   ? 26.459  7.279   10.498  0.50 20.37 ? 302 6Z9 A C17 1 
HETATM 8634 C  C18 A 6Z9 F 3 .   ? 25.602  8.440   10.686  0.50 28.22 ? 302 6Z9 A C18 1 
HETATM 8635 C  C18 B 6Z9 F 3 .   ? 25.545  8.491   10.784  0.50 22.39 ? 302 6Z9 A C18 1 
HETATM 8636 C  C19 A 6Z9 F 3 .   ? 26.299  9.686   11.206  0.50 29.55 ? 302 6Z9 A C19 1 
HETATM 8637 C  C19 B 6Z9 F 3 .   ? 26.340  9.608   11.435  0.50 22.54 ? 302 6Z9 A C19 1 
HETATM 8638 C  C20 A 6Z9 F 3 .   ? 27.392  10.107  10.217  0.50 30.33 ? 302 6Z9 A C20 1 
HETATM 8639 C  C20 B 6Z9 F 3 .   ? 27.515  10.056  10.547  0.50 24.02 ? 302 6Z9 A C20 1 
HETATM 8640 C  C21 A 6Z9 F 3 .   ? 28.371  8.994   9.964   0.50 30.60 ? 302 6Z9 A C21 1 
HETATM 8641 C  C21 B 6Z9 F 3 .   ? 28.284  8.920   9.932   0.50 22.35 ? 302 6Z9 A C21 1 
HETATM 8642 C  C22 A 6Z9 F 3 .   ? 27.979  7.644   10.071  0.50 32.00 ? 302 6Z9 A C22 1 
HETATM 8643 C  C22 B 6Z9 F 3 .   ? 27.764  7.611   9.871   0.50 24.49 ? 302 6Z9 A C22 1 
HETATM 8644 C  C23 A 6Z9 F 3 .   ? 28.879  6.607   9.829   0.50 35.58 ? 302 6Z9 A C23 1 
HETATM 8645 C  C23 B 6Z9 F 3 .   ? 28.459  6.575   9.268   0.50 23.46 ? 302 6Z9 A C23 1 
HETATM 8646 C  C24 A 6Z9 F 3 .   ? 30.192  6.911   9.459   0.50 35.34 ? 302 6Z9 A C24 1 
HETATM 8647 C  C24 B 6Z9 F 3 .   ? 29.721  6.822   8.713   0.50 22.15 ? 302 6Z9 A C24 1 
HETATM 8648 C  C25 A 6Z9 F 3 .   ? 30.589  8.248   9.354   0.50 35.34 ? 302 6Z9 A C25 1 
HETATM 8649 C  C25 B 6Z9 F 3 .   ? 30.255  8.111   8.769   0.50 24.65 ? 302 6Z9 A C25 1 
HETATM 8650 C  C26 A 6Z9 F 3 .   ? 29.691  9.288   9.607   0.50 33.53 ? 302 6Z9 A C26 1 
HETATM 8651 C  C26 B 6Z9 F 3 .   ? 29.547  9.152   9.378   0.50 24.42 ? 302 6Z9 A C26 1 
HETATM 8652 C  C27 A 6Z9 F 3 .   ? 25.191  4.609   11.224  0.50 14.71 ? 302 6Z9 A C27 1 
HETATM 8653 C  C27 B 6Z9 F 3 .   ? 25.196  4.589   11.218  0.50 16.10 ? 302 6Z9 A C27 1 
HETATM 8654 O  O30 A 6Z9 F 3 .   ? 24.730  1.681   9.950   0.50 11.14 ? 302 6Z9 A O30 1 
HETATM 8655 O  O30 B 6Z9 F 3 .   ? 24.717  1.666   9.943   0.50 12.56 ? 302 6Z9 A O30 1 
HETATM 8656 S  S2  A 6Z9 F 3 .   ? 23.599  2.549   10.275  0.50 10.39 ? 302 6Z9 A S2  1 
HETATM 8657 S  S2  B 6Z9 F 3 .   ? 23.587  2.552   10.264  0.50 11.54 ? 302 6Z9 A S2  1 
HETATM 8658 O  O1  A 6Z9 F 3 .   ? 23.064  3.234   9.067   0.50 12.52 ? 302 6Z9 A O1  1 
HETATM 8659 O  O1  B 6Z9 F 3 .   ? 23.065  3.228   9.045   0.50 14.04 ? 302 6Z9 A O1  1 
HETATM 8660 N  N29 A 6Z9 F 3 .   ? 22.366  1.677   10.911  0.50 9.32  ? 302 6Z9 A N29 1 
HETATM 8661 N  N29 B 6Z9 F 3 .   ? 22.357  1.663   10.906  0.50 10.48 ? 302 6Z9 A N29 1 
HETATM 8662 F  F28 A 6Z9 F 3 .   ? 25.821  4.421   10.064  0.50 13.61 ? 302 6Z9 A F28 1 
HETATM 8663 F  F28 B 6Z9 F 3 .   ? 25.807  4.423   10.044  0.50 15.61 ? 302 6Z9 A F28 1 
HETATM 8664 S  S9  A 6Z9 F 3 .   ? 25.516  6.989   14.584  0.50 22.12 ? 302 6Z9 A S9  1 
HETATM 8665 S  S9  B 6Z9 F 3 .   ? 25.535  6.792   14.710  0.50 27.96 ? 302 6Z9 A S9  1 
HETATM 8666 O  O14 A 6Z9 F 3 .   ? 26.754  7.880   14.279  0.50 19.90 ? 302 6Z9 A O14 1 
HETATM 8667 O  O14 B 6Z9 F 3 .   ? 26.185  5.712   15.560  0.50 25.50 ? 302 6Z9 A O14 1 
HETATM 8668 O  O13 A 6Z9 F 3 .   ? 26.234  4.033   15.885  0.50 17.49 ? 302 6Z9 A O13 1 
HETATM 8669 O  O13 B 6Z9 F 3 .   ? 23.717  8.796   13.809  0.50 25.13 ? 302 6Z9 A O13 1 
HETATM 8670 O  O10 A 6Z9 F 3 .   ? 24.519  8.192   14.565  0.50 21.28 ? 302 6Z9 A O10 1 
HETATM 8671 O  O10 B 6Z9 F 3 .   ? 26.691  7.780   14.332  0.50 26.81 ? 302 6Z9 A O10 1 
HETATM 8672 F  F7  A 6Z9 F 3 .   ? 23.412  5.028   14.874  0.50 19.37 ? 302 6Z9 A F7  1 
HETATM 8673 F  F7  B 6Z9 F 3 .   ? 23.461  4.936   14.903  0.50 20.47 ? 302 6Z9 A F7  1 
HETATM 8674 F  F5  A 6Z9 F 3 .   ? 22.498  3.196   13.159  0.50 13.92 ? 302 6Z9 A F5  1 
HETATM 8675 F  F5  B 6Z9 F 3 .   ? 22.504  3.168   13.163  0.50 15.69 ? 302 6Z9 A F5  1 
HETATM 8676 N  N16 A 6Z9 F 3 .   ? 26.752  6.389   11.666  0.50 21.38 ? 302 6Z9 A N16 1 
HETATM 8677 N  N16 B 6Z9 F 3 .   ? 26.770  6.344   11.635  0.50 19.85 ? 302 6Z9 A N16 1 
HETATM 8678 ZN ZN  . ZN  G 2 .   ? -8.200  3.590   4.828   1.00 4.90  ? 301 ZN  B ZN  1 
HETATM 8679 C  C3  . 6Z9 H 3 .   ? -8.748  7.086   5.596   1.00 13.24 ? 302 6Z9 B C3  1 
HETATM 8680 C  C4  . 6Z9 H 3 .   ? -8.203  7.215   4.315   1.00 14.72 ? 302 6Z9 B C4  1 
HETATM 8681 C  C8  . 6Z9 H 3 .   ? -9.406  9.189   3.724   1.00 20.46 ? 302 6Z9 B C8  1 
HETATM 8682 C  C6  . 6Z9 H 3 .   ? -8.535  8.163   3.369   1.00 19.48 ? 302 6Z9 B C6  1 
HETATM 8683 C  C11 . 6Z9 H 3 .   ? -8.292  11.799  2.088   1.00 27.83 ? 302 6Z9 B C11 1 
HETATM 8684 C  C12 . 6Z9 H 3 .   ? -7.700  12.164  3.448   1.00 34.12 ? 302 6Z9 B C12 1 
HETATM 8685 C  C15 . 6Z9 H 3 .   ? -9.974  9.137   5.016   1.00 20.16 ? 302 6Z9 B C15 1 
HETATM 8686 C  C17 . 6Z9 H 3 .   ? -10.879 11.084  6.611   1.00 25.36 ? 302 6Z9 B C17 1 
HETATM 8687 C  C18 . 6Z9 H 3 .   ? -9.713  12.052  6.541   1.00 24.19 ? 302 6Z9 B C18 1 
HETATM 8688 C  C19 . 6Z9 H 3 .   ? -10.030 13.482  6.147   1.00 31.99 ? 302 6Z9 B C19 1 
HETATM 8689 C  C20 . 6Z9 H 3 .   ? -11.283 13.941  6.935   1.00 31.98 ? 302 6Z9 B C20 1 
HETATM 8690 C  C21 . 6Z9 H 3 .   ? -12.467 13.014  6.863   1.00 31.66 ? 302 6Z9 B C21 1 
HETATM 8691 C  C22 . 6Z9 H 3 .   ? -12.279 11.614  6.720   1.00 34.49 ? 302 6Z9 B C22 1 
HETATM 8692 C  C23 . 6Z9 H 3 .   ? -13.381 10.721  6.614   1.00 41.80 ? 302 6Z9 B C23 1 
HETATM 8693 C  C24 . 6Z9 H 3 .   ? -14.686 11.250  6.686   1.00 44.79 ? 302 6Z9 B C24 1 
HETATM 8694 C  C25 . 6Z9 H 3 .   ? -14.873 12.651  6.846   1.00 38.50 ? 302 6Z9 B C25 1 
HETATM 8695 C  C26 . 6Z9 H 3 .   ? -13.773 13.524  6.945   1.00 35.41 ? 302 6Z9 B C26 1 
HETATM 8696 C  C27 . 6Z9 H 3 .   ? -9.664  8.083   5.889   1.00 16.45 ? 302 6Z9 B C27 1 
HETATM 8697 O  O30 . 6Z9 H 3 .   ? -9.654  5.147   7.169   1.00 9.67  ? 302 6Z9 B O30 1 
HETATM 8698 S  S2  . 6Z9 H 3 .   ? -8.399  5.789   6.866   1.00 9.82  ? 302 6Z9 B S2  1 
HETATM 8699 O  O1  . 6Z9 H 3 .   ? -7.653  6.350   8.020   1.00 12.21 ? 302 6Z9 B O1  1 
HETATM 8700 N  N29 . 6Z9 H 3 .   ? -7.447  4.780   6.042   1.00 8.73  ? 302 6Z9 B N29 1 
HETATM 8701 F  F28 . 6Z9 H 3 .   ? -10.289 8.048   7.088   1.00 15.28 ? 302 6Z9 B F28 1 
HETATM 8702 S  S9  . 6Z9 H 3 .   ? -9.573  10.503  2.464   1.00 26.71 ? 302 6Z9 B S9  1 
HETATM 8703 O  O14 . 6Z9 H 3 .   ? -9.851  9.836   1.112   1.00 27.66 ? 302 6Z9 B O14 1 
HETATM 8704 O  O13 . 6Z9 H 3 .   ? -7.225  13.511  3.640   1.00 37.83 ? 302 6Z9 B O13 1 
HETATM 8705 O  O10 . 6Z9 H 3 .   ? -10.791 11.350  2.876   1.00 29.86 ? 302 6Z9 B O10 1 
HETATM 8706 F  F7  . 6Z9 H 3 .   ? -7.871  8.136   2.143   1.00 22.94 ? 302 6Z9 B F7  1 
HETATM 8707 F  F5  . 6Z9 H 3 .   ? -7.341  6.286   3.803   1.00 16.70 ? 302 6Z9 B F5  1 
HETATM 8708 N  N16 . 6Z9 H 3 .   ? -10.914 10.146  5.450   1.00 23.86 ? 302 6Z9 B N16 1 
HETATM 8709 ZN ZN  . ZN  I 2 .   ? 37.657  2.361   -30.947 1.00 7.77  ? 301 ZN  C ZN  1 
HETATM 8710 C  C3  . 6Z9 J 3 .   ? 38.972  5.676   -31.723 1.00 15.71 ? 302 6Z9 C C3  1 
HETATM 8711 C  C4  . 6Z9 J 3 .   ? 38.370  5.843   -30.455 1.00 15.05 ? 302 6Z9 C C4  1 
HETATM 8712 C  C8  . 6Z9 J 3 .   ? 39.914  7.557   -29.859 1.00 21.21 ? 302 6Z9 C C8  1 
HETATM 8713 C  C6  . 6Z9 J 3 .   ? 38.840  6.716   -29.517 1.00 19.30 ? 302 6Z9 C C6  1 
HETATM 8714 C  C11 . 6Z9 J 3 .   ? 40.608  7.859   -26.915 1.00 30.60 ? 302 6Z9 C C11 1 
HETATM 8715 C  C12 . 6Z9 J 3 .   ? 41.038  6.399   -26.839 1.00 29.15 ? 302 6Z9 C C12 1 
HETATM 8716 C  C15 . 6Z9 J 3 .   ? 40.606  7.377   -31.064 1.00 23.14 ? 302 6Z9 C C15 1 
HETATM 8717 C  C17 . 6Z9 J 3 .   ? 41.413  9.094   -32.638 1.00 26.84 ? 302 6Z9 C C17 1 
HETATM 8718 C  C18 . 6Z9 J 3 .   ? 40.411  10.196  -32.269 1.00 30.44 ? 302 6Z9 C C18 1 
HETATM 8719 C  C19 . 6Z9 J 3 .   ? 40.844  11.527  -32.875 1.00 32.17 ? 302 6Z9 C C19 1 
HETATM 8720 C  C20 . 6Z9 J 3 .   ? 42.270  11.873  -32.462 1.00 29.69 ? 302 6Z9 C C20 1 
HETATM 8721 C  C21 . 6Z9 J 3 .   ? 43.194  10.810  -33.021 1.00 27.77 ? 302 6Z9 C C21 1 
HETATM 8722 C  C22 . 6Z9 J 3 .   ? 42.746  9.463   -33.155 1.00 29.42 ? 302 6Z9 C C22 1 
HETATM 8723 C  C23 . 6Z9 J 3 .   ? 43.544  8.463   -33.716 1.00 34.15 ? 302 6Z9 C C23 1 
HETATM 8724 C  C24 . 6Z9 J 3 .   ? 44.832  8.835   -34.145 1.00 34.86 ? 302 6Z9 C C24 1 
HETATM 8725 C  C25 . 6Z9 J 3 .   ? 45.259  10.171  -33.999 1.00 33.23 ? 302 6Z9 C C25 1 
HETATM 8726 C  C26 . 6Z9 J 3 .   ? 44.462  11.187  -33.461 1.00 31.00 ? 302 6Z9 C C26 1 
HETATM 8727 C  C27 . 6Z9 J 3 .   ? 40.081  6.476   -32.022 1.00 17.16 ? 302 6Z9 C C27 1 
HETATM 8728 O  O30 . 6Z9 J 3 .   ? 39.527  3.523   -33.244 1.00 12.00 ? 302 6Z9 C O30 1 
HETATM 8729 S  S2  . 6Z9 J 3 .   ? 38.439  4.412   -33.012 1.00 12.35 ? 302 6Z9 C S2  1 
HETATM 8730 O  O1  . 6Z9 J 3 .   ? 37.914  5.041   -34.242 1.00 14.44 ? 302 6Z9 C O1  1 
HETATM 8731 N  N29 . 6Z9 J 3 .   ? 37.197  3.625   -32.293 1.00 10.06 ? 302 6Z9 C N29 1 
HETATM 8732 F  F28 . 6Z9 J 3 .   ? 40.705  6.243   -33.200 1.00 16.75 ? 302 6Z9 C F28 1 
HETATM 8733 S  S9  . 6Z9 J 3 .   ? 40.348  8.651   -28.511 1.00 27.09 ? 302 6Z9 C S9  1 
HETATM 8734 O  O14 . 6Z9 J 3 .   ? 41.664  9.437   -28.851 1.00 25.99 ? 302 6Z9 C O14 1 
HETATM 8735 O  O13 . 6Z9 J 3 .   ? 41.239  5.768   -28.062 1.00 43.13 ? 302 6Z9 C O13 1 
HETATM 8736 O  O10 . 6Z9 J 3 .   ? 39.339  9.868   -28.485 1.00 31.24 ? 302 6Z9 C O10 1 
HETATM 8737 F  F7  . 6Z9 J 3 .   ? 38.205  6.811   -28.304 1.00 22.21 ? 302 6Z9 C F7  1 
HETATM 8738 F  F5  . 6Z9 J 3 .   ? 37.241  5.051   -30.085 1.00 16.22 ? 302 6Z9 C F5  1 
HETATM 8739 N  N16 . 6Z9 J 3 .   ? 41.660  8.224   -31.488 1.00 23.56 ? 302 6Z9 C N16 1 
HETATM 8740 ZN ZN  . ZN  K 2 .   ? 6.830   5.559   -38.444 1.00 4.97  ? 301 ZN  D ZN  1 
HETATM 8741 C  C3  . 6Z9 L 3 .   ? 6.324   9.069   -37.771 1.00 12.75 ? 302 6Z9 D C3  1 
HETATM 8742 C  C4  . 6Z9 L 3 .   ? 6.856   9.161   -39.036 1.00 14.26 ? 302 6Z9 D C4  1 
HETATM 8743 C  C8  . 6Z9 L 3 .   ? 5.648   11.159  -39.603 1.00 16.74 ? 302 6Z9 D C8  1 
HETATM 8744 C  C6  . 6Z9 L 3 .   ? 6.549   10.178  -39.918 1.00 17.16 ? 302 6Z9 D C6  1 
HETATM 8745 C  C11 . 6Z9 L 3 .   ? 7.087   13.537  -41.247 1.00 28.17 ? 302 6Z9 D C11 1 
HETATM 8746 C  C12 . 6Z9 L 3 .   ? 7.230   14.506  -40.048 1.00 38.93 ? 302 6Z9 D C12 1 
HETATM 8747 C  C15 . 6Z9 L 3 .   ? 5.046   11.110  -38.353 1.00 16.38 ? 302 6Z9 D C15 1 
HETATM 8748 C  C17 . 6Z9 L 3 .   ? 3.883   12.809  -36.707 1.00 23.16 ? 302 6Z9 D C17 1 
HETATM 8749 C  C18 . 6Z9 L 3 .   ? 5.165   13.573  -36.541 1.00 22.01 ? 302 6Z9 D C18 1 
HETATM 8750 C  C19 . 6Z9 L 3 .   ? 5.212   15.038  -36.960 1.00 26.76 ? 302 6Z9 D C19 1 
HETATM 8751 C  C20 . 6Z9 L 3 .   ? 3.994   15.750  -36.381 1.00 24.22 ? 302 6Z9 D C20 1 
HETATM 8752 C  C21 . 6Z9 L 3 .   ? 2.691   15.017  -36.632 1.00 23.81 ? 302 6Z9 D C21 1 
HETATM 8753 C  C22 . 6Z9 L 3 .   ? 2.627   13.603  -36.798 1.00 23.63 ? 302 6Z9 D C22 1 
HETATM 8754 C  C23 . 6Z9 L 3 .   ? 1.435   12.930  -37.067 1.00 30.36 ? 302 6Z9 D C23 1 
HETATM 8755 C  C24 . 6Z9 L 3 .   ? 0.254   13.687  -37.172 1.00 30.29 ? 302 6Z9 D C24 1 
HETATM 8756 C  C25 . 6Z9 L 3 .   ? 0.297   15.093  -37.003 1.00 29.48 ? 302 6Z9 D C25 1 
HETATM 8757 C  C26 . 6Z9 L 3 .   ? 1.511   15.749  -36.739 1.00 26.74 ? 302 6Z9 D C26 1 
HETATM 8758 C  C27 . 6Z9 L 3 .   ? 5.418   10.097  -37.510 1.00 13.44 ? 302 6Z9 D C27 1 
HETATM 8759 O  O30 . 6Z9 L 3 .   ? 5.373   7.208   -36.095 1.00 8.41  ? 302 6Z9 D O30 1 
HETATM 8760 S  S2  . 6Z9 L 3 .   ? 6.656   7.805   -36.425 1.00 8.88  ? 302 6Z9 D S2  1 
HETATM 8761 O  O1  . 6Z9 L 3 .   ? 7.429   8.365   -35.301 1.00 10.77 ? 302 6Z9 D O1  1 
HETATM 8762 N  N29 . 6Z9 L 3 .   ? 7.627   6.823   -37.193 1.00 7.54  ? 302 6Z9 D N29 1 
HETATM 8763 F  F28 . 6Z9 L 3 .   ? 4.762   10.062  -36.283 1.00 14.29 ? 302 6Z9 D F28 1 
HETATM 8764 S  S9  . 6Z9 L 3 .   ? 5.643   12.417  -40.924 1.00 24.84 ? 302 6Z9 D S9  1 
HETATM 8765 O  O14 . 6Z9 L 3 .   ? 5.107   11.764  -42.167 1.00 24.52 ? 302 6Z9 D O14 1 
HETATM 8766 O  O13 . 6Z9 L 3 .   ? 8.209   15.561  -40.047 1.00 38.25 ? 302 6Z9 D O13 1 
HETATM 8767 O  O10 . 6Z9 L 3 .   ? 4.499   13.432  -40.538 1.00 26.57 ? 302 6Z9 D O10 1 
HETATM 8768 F  F7  . 6Z9 L 3 .   ? 7.143   10.150  -41.156 1.00 21.01 ? 302 6Z9 D F7  1 
HETATM 8769 F  F5  . 6Z9 L 3 .   ? 7.755   8.224   -39.494 1.00 15.14 ? 302 6Z9 D F5  1 
HETATM 8770 N  N16 . 6Z9 L 3 .   ? 4.049   12.079  -37.958 1.00 22.53 ? 302 6Z9 D N16 1 
HETATM 8771 O  O   . HOH M 4 .   ? 30.391  14.383  4.368   1.00 27.09 ? 401 HOH A O   1 
HETATM 8772 O  O   . HOH M 4 .   ? 24.681  -0.283  20.031  1.00 24.47 ? 402 HOH A O   1 
HETATM 8773 O  O   . HOH M 4 .   ? 42.257  -0.400  5.805   1.00 29.23 ? 403 HOH A O   1 
HETATM 8774 O  O   . HOH M 4 .   ? 4.645   -0.318  -8.400  1.00 26.77 ? 404 HOH A O   1 
HETATM 8775 O  O   . HOH M 4 .   ? 28.153  -24.217 8.311   1.00 31.70 ? 405 HOH A O   1 
HETATM 8776 O  O   . HOH M 4 .   ? 14.139  5.174   23.921  1.00 42.48 ? 406 HOH A O   1 
HETATM 8777 O  O   . HOH M 4 .   ? 13.007  14.111  14.204  1.00 19.19 ? 407 HOH A O   1 
HETATM 8778 O  O   . HOH M 4 .   ? 36.805  6.083   11.657  1.00 21.78 ? 408 HOH A O   1 
HETATM 8779 O  O   . HOH M 4 .   ? 18.468  -3.303  -5.821  1.00 30.39 ? 409 HOH A O   1 
HETATM 8780 O  O   . HOH M 4 .   ? 19.762  12.233  24.434  1.00 29.09 ? 410 HOH A O   1 
HETATM 8781 O  O   . HOH M 4 .   ? 34.914  -11.230 -3.199  1.00 31.00 ? 411 HOH A O   1 
HETATM 8782 O  O   . HOH M 4 .   ? 6.117   -3.450  20.923  1.00 27.53 ? 412 HOH A O   1 
HETATM 8783 O  O   . HOH M 4 .   ? 6.435   15.800  15.946  1.00 28.55 ? 413 HOH A O   1 
HETATM 8784 O  O   . HOH M 4 .   ? 21.602  16.534  31.236  1.00 34.72 ? 414 HOH A O   1 
HETATM 8785 O  O   . HOH M 4 .   ? 15.870  -12.146 26.888  1.00 19.76 ? 415 HOH A O   1 
HETATM 8786 O  O   . HOH M 4 .   ? 43.701  -4.667  12.832  1.00 21.72 ? 416 HOH A O   1 
HETATM 8787 O  O   . HOH M 4 .   ? 17.946  3.050   12.829  1.00 10.27 ? 417 HOH A O   1 
HETATM 8788 O  O   . HOH M 4 .   ? 41.703  5.742   5.511   1.00 31.94 ? 418 HOH A O   1 
HETATM 8789 O  O   . HOH M 4 .   ? 30.038  -4.016  -5.403  1.00 43.90 ? 419 HOH A O   1 
HETATM 8790 O  O   . HOH M 4 .   ? 11.799  16.272  15.070  1.00 30.14 ? 420 HOH A O   1 
HETATM 8791 O  O   . HOH M 4 .   ? 7.627   -10.647 3.394   1.00 25.74 ? 421 HOH A O   1 
HETATM 8792 O  O   . HOH M 4 .   ? 19.872  14.011  28.671  1.00 21.20 ? 422 HOH A O   1 
HETATM 8793 O  O   . HOH M 4 .   ? 45.154  -4.633  7.711   1.00 24.21 ? 423 HOH A O   1 
HETATM 8794 O  O   . HOH M 4 .   ? 13.651  16.436  11.645  1.00 11.91 ? 424 HOH A O   1 
HETATM 8795 O  O   . HOH M 4 .   ? 33.148  -15.271 3.792   1.00 21.61 ? 425 HOH A O   1 
HETATM 8796 O  O   . HOH M 4 .   ? 19.292  9.574   32.344  1.00 17.58 ? 426 HOH A O   1 
HETATM 8797 O  O   . HOH M 4 .   ? 10.566  -3.335  2.628   1.00 10.56 ? 427 HOH A O   1 
HETATM 8798 O  O   . HOH M 4 .   ? 9.492   -4.960  16.659  1.00 30.15 ? 428 HOH A O   1 
HETATM 8799 O  O   . HOH M 4 .   ? 9.864   -14.753 1.607   1.00 27.95 ? 429 HOH A O   1 
HETATM 8800 O  O   . HOH M 4 .   ? 34.499  3.487   31.510  1.00 31.38 ? 430 HOH A O   1 
HETATM 8801 O  O   . HOH M 4 .   ? 14.117  13.044  28.729  1.00 33.90 ? 431 HOH A O   1 
HETATM 8802 O  O   . HOH M 4 .   ? 47.168  -3.753  10.154  1.00 25.44 ? 432 HOH A O   1 
HETATM 8803 O  O   . HOH M 4 .   ? 28.766  2.228   -1.169  1.00 23.99 ? 433 HOH A O   1 
HETATM 8804 O  O   . HOH M 4 .   ? 35.943  -14.941 4.086   1.00 27.45 ? 434 HOH A O   1 
HETATM 8805 O  O   . HOH M 4 .   ? 18.020  -15.225 6.131   1.00 19.18 ? 435 HOH A O   1 
HETATM 8806 O  O   . HOH M 4 .   ? 42.028  2.472   29.404  1.00 22.90 ? 436 HOH A O   1 
HETATM 8807 O  O   . HOH M 4 .   ? 37.308  7.240   30.059  1.00 35.77 ? 437 HOH A O   1 
HETATM 8808 O  O   . HOH M 4 .   ? 27.982  -21.654 2.048   1.00 29.42 ? 438 HOH A O   1 
HETATM 8809 O  O   . HOH M 4 .   ? 14.335  -10.068 25.962  1.00 15.84 ? 439 HOH A O   1 
HETATM 8810 O  O   . HOH M 4 .   ? 13.890  1.610   -0.196  1.00 16.84 ? 440 HOH A O   1 
HETATM 8811 O  O   . HOH M 4 .   ? 11.219  3.354   19.148  1.00 18.12 ? 441 HOH A O   1 
HETATM 8812 O  O   . HOH M 4 .   ? 15.184  -6.924  21.082  1.00 9.97  ? 442 HOH A O   1 
HETATM 8813 O  O   . HOH M 4 .   ? 42.423  5.252   -4.881  1.00 31.23 ? 443 HOH A O   1 
HETATM 8814 O  O   . HOH M 4 .   ? 42.726  -10.369 19.099  1.00 27.93 ? 444 HOH A O   1 
HETATM 8815 O  O   . HOH M 4 .   ? 39.423  -12.735 19.957  1.00 22.50 ? 445 HOH A O   1 
HETATM 8816 O  O   . HOH M 4 .   ? 11.580  1.312   -4.168  1.00 34.57 ? 446 HOH A O   1 
HETATM 8817 O  O   . HOH M 4 .   ? 27.587  -21.209 24.517  1.00 27.72 ? 447 HOH A O   1 
HETATM 8818 O  O   . HOH M 4 .   ? 7.732   -8.154  11.759  1.00 21.10 ? 448 HOH A O   1 
HETATM 8819 O  O   . HOH M 4 .   ? 12.410  5.144   29.254  1.00 41.59 ? 449 HOH A O   1 
HETATM 8820 O  O   . HOH M 4 .   ? 11.971  -10.488 27.251  1.00 16.07 ? 450 HOH A O   1 
HETATM 8821 O  O   . HOH M 4 .   ? 32.748  -16.086 12.777  1.00 34.41 ? 451 HOH A O   1 
HETATM 8822 O  O   . HOH M 4 .   ? 12.454  -2.601  10.962  1.00 7.10  ? 452 HOH A O   1 
HETATM 8823 O  O   . HOH M 4 .   ? 9.272   11.386  1.105   1.00 13.54 ? 453 HOH A O   1 
HETATM 8824 O  O   . HOH M 4 .   ? 41.620  -10.103 23.460  1.00 42.11 ? 454 HOH A O   1 
HETATM 8825 O  O   . HOH M 4 .   ? 26.579  5.445   -3.546  1.00 28.03 ? 455 HOH A O   1 
HETATM 8826 O  O   . HOH M 4 .   ? 37.958  -7.801  24.575  1.00 23.17 ? 456 HOH A O   1 
HETATM 8827 O  O   . HOH M 4 .   ? 40.983  -10.600 9.810   1.00 17.33 ? 457 HOH A O   1 
HETATM 8828 O  O   . HOH M 4 .   ? 10.265  4.837   8.681   1.00 11.39 ? 458 HOH A O   1 
HETATM 8829 O  O   . HOH M 4 .   ? 10.587  6.198   15.305  1.00 12.76 ? 459 HOH A O   1 
HETATM 8830 O  O   . HOH M 4 .   ? 27.843  3.929   33.529  1.00 26.89 ? 460 HOH A O   1 
HETATM 8831 O  O   . HOH M 4 .   ? 32.226  -16.921 10.465  1.00 28.68 ? 461 HOH A O   1 
HETATM 8832 O  O   . HOH M 4 .   ? 5.427   15.990  13.420  1.00 27.85 ? 462 HOH A O   1 
HETATM 8833 O  O   . HOH M 4 .   ? 19.015  -6.540  -11.931 1.00 33.65 ? 463 HOH A O   1 
HETATM 8834 O  O   . HOH M 4 .   ? 5.871   -3.969  -8.235  1.00 25.50 ? 464 HOH A O   1 
HETATM 8835 O  O   . HOH M 4 .   ? 25.500  -18.554 12.586  1.00 19.96 ? 465 HOH A O   1 
HETATM 8836 O  O   . HOH M 4 .   ? 18.474  20.696  8.032   1.00 29.55 ? 466 HOH A O   1 
HETATM 8837 O  O   . HOH M 4 .   ? 31.408  5.485   32.547  1.00 21.92 ? 467 HOH A O   1 
HETATM 8838 O  O   . HOH M 4 .   ? 17.249  -16.989 3.716   1.00 38.48 ? 468 HOH A O   1 
HETATM 8839 O  O   . HOH M 4 .   ? 34.113  1.869   -5.639  1.00 28.98 ? 469 HOH A O   1 
HETATM 8840 O  O   . HOH M 4 .   ? 42.143  2.378   1.125   1.00 16.10 ? 470 HOH A O   1 
HETATM 8841 O  O   . HOH M 4 .   ? 28.471  -4.245  2.647   1.00 10.48 ? 471 HOH A O   1 
HETATM 8842 O  O   . HOH M 4 .   ? 40.192  -3.875  -1.956  1.00 30.73 ? 472 HOH A O   1 
HETATM 8843 O  O   . HOH M 4 .   ? 10.718  12.326  20.499  1.00 23.60 ? 473 HOH A O   1 
HETATM 8844 O  O   . HOH M 4 .   ? 38.731  -5.581  -2.986  1.00 29.73 ? 474 HOH A O   1 
HETATM 8845 O  O   . HOH M 4 .   ? 24.570  -7.401  -7.664  1.00 34.10 ? 475 HOH A O   1 
HETATM 8846 O  O   . HOH M 4 .   ? 36.092  -7.199  26.352  1.00 20.63 ? 476 HOH A O   1 
HETATM 8847 O  O   . HOH M 4 .   ? 25.901  2.473   -2.577  1.00 33.09 ? 477 HOH A O   1 
HETATM 8848 O  O   . HOH M 4 .   ? 30.374  -8.789  -2.549  1.00 20.60 ? 478 HOH A O   1 
HETATM 8849 O  O   . HOH M 4 .   ? 5.468   -11.953 13.377  1.00 16.44 ? 479 HOH A O   1 
HETATM 8850 O  O   . HOH M 4 .   ? 11.180  -4.807  -4.777  1.00 35.77 ? 480 HOH A O   1 
HETATM 8851 O  O   . HOH M 4 .   ? 36.662  -4.395  -0.735  1.00 19.65 ? 481 HOH A O   1 
HETATM 8852 O  O   . HOH M 4 .   ? 22.355  7.233   -4.016  1.00 29.96 ? 482 HOH A O   1 
HETATM 8853 O  O   . HOH M 4 .   ? 31.476  -13.419 2.561   1.00 22.37 ? 483 HOH A O   1 
HETATM 8854 O  O   . HOH M 4 .   ? 39.187  -15.896 16.972  1.00 26.78 ? 484 HOH A O   1 
HETATM 8855 O  O   . HOH M 4 .   ? 37.300  10.130  24.084  1.00 31.39 ? 485 HOH A O   1 
HETATM 8856 O  O   . HOH M 4 .   ? 11.349  3.818   -0.123  1.00 22.79 ? 486 HOH A O   1 
HETATM 8857 O  O   . HOH M 4 .   ? 11.353  5.191   2.158   1.00 9.15  ? 487 HOH A O   1 
HETATM 8858 O  O   . HOH M 4 .   ? 33.716  -13.594 26.608  1.00 24.13 ? 488 HOH A O   1 
HETATM 8859 O  O   . HOH M 4 .   ? 23.685  -16.237 29.661  1.00 21.91 ? 489 HOH A O   1 
HETATM 8860 O  O   . HOH M 4 .   ? 12.565  -12.399 16.481  1.00 18.38 ? 490 HOH A O   1 
HETATM 8861 O  O   . HOH M 4 .   ? 38.477  3.878   11.488  1.00 20.91 ? 491 HOH A O   1 
HETATM 8862 O  O   . HOH M 4 .   ? 4.744   -9.019  25.716  1.00 26.14 ? 492 HOH A O   1 
HETATM 8863 O  O   . HOH M 4 .   ? 10.157  -4.136  19.440  1.00 22.71 ? 493 HOH A O   1 
HETATM 8864 O  O   . HOH M 4 .   ? 17.325  0.218   28.465  1.00 16.41 ? 494 HOH A O   1 
HETATM 8865 O  O   . HOH M 4 .   ? 39.842  -12.307 11.717  1.00 19.45 ? 495 HOH A O   1 
HETATM 8866 O  O   . HOH M 4 .   ? 11.083  -5.147  0.700   1.00 22.12 ? 496 HOH A O   1 
HETATM 8867 O  O   . HOH M 4 .   ? 19.353  14.122  5.086   1.00 9.70  ? 497 HOH A O   1 
HETATM 8868 O  O   . HOH M 4 .   ? 19.024  11.815  -0.765  1.00 17.30 ? 498 HOH A O   1 
HETATM 8869 O  O   . HOH M 4 .   ? 29.807  -15.707 -1.716  1.00 20.66 ? 499 HOH A O   1 
HETATM 8870 O  O   . HOH M 4 .   ? 34.995  -0.966  30.603  1.00 29.00 ? 500 HOH A O   1 
HETATM 8871 O  O   . HOH M 4 .   ? 6.074   11.694  7.889   1.00 7.31  ? 501 HOH A O   1 
HETATM 8872 O  O   . HOH M 4 .   ? 23.027  -12.461 9.733   1.00 9.70  ? 502 HOH A O   1 
HETATM 8873 O  O   . HOH M 4 .   ? 32.747  6.547   13.125  1.00 29.77 ? 503 HOH A O   1 
HETATM 8874 O  O   . HOH M 4 .   ? 31.091  -21.010 8.536   1.00 28.96 ? 504 HOH A O   1 
HETATM 8875 O  O   . HOH M 4 .   ? 19.471  -0.702  26.586  1.00 11.89 ? 505 HOH A O   1 
HETATM 8876 O  O   . HOH M 4 .   ? 7.395   -6.795  2.472   1.00 26.30 ? 506 HOH A O   1 
HETATM 8877 O  O   . HOH M 4 .   ? 14.018  1.830   -2.956  1.00 19.19 ? 507 HOH A O   1 
HETATM 8878 O  O   . HOH M 4 .   ? 11.304  -6.545  -7.793  1.00 28.45 ? 508 HOH A O   1 
HETATM 8879 O  O   . HOH M 4 .   ? 26.050  11.082  31.155  1.00 20.30 ? 509 HOH A O   1 
HETATM 8880 O  O   . HOH M 4 .   ? 29.215  -17.020 14.996  1.00 25.95 ? 510 HOH A O   1 
HETATM 8881 O  O   . HOH M 4 .   ? 17.145  0.667   -0.465  1.00 16.33 ? 511 HOH A O   1 
HETATM 8882 O  O   . HOH M 4 .   ? 32.889  4.892   20.167  1.00 23.30 ? 512 HOH A O   1 
HETATM 8883 O  O   . HOH M 4 .   ? 31.756  -17.103 20.608  1.00 27.89 ? 513 HOH A O   1 
HETATM 8884 O  O   . HOH M 4 .   ? 19.332  -18.440 26.315  1.00 21.70 ? 514 HOH A O   1 
HETATM 8885 O  O   . HOH M 4 .   ? 10.467  -9.175  -8.153  1.00 35.12 ? 515 HOH A O   1 
HETATM 8886 O  O   . HOH M 4 .   ? 8.604   2.956   7.235   1.00 7.31  ? 516 HOH A O   1 
HETATM 8887 O  O   . HOH M 4 .   ? 7.429   4.955   11.165  1.00 8.71  ? 517 HOH A O   1 
HETATM 8888 O  O   . HOH M 4 .   ? 8.722   -6.420  7.266   1.00 16.25 ? 518 HOH A O   1 
HETATM 8889 O  O   . HOH M 4 .   ? 8.069   -10.369 26.301  1.00 26.99 ? 519 HOH A O   1 
HETATM 8890 O  O   . HOH M 4 .   ? 20.643  -9.954  31.852  1.00 16.04 ? 520 HOH A O   1 
HETATM 8891 O  O   . HOH M 4 .   ? 25.744  11.973  21.171  1.00 39.08 ? 521 HOH A O   1 
HETATM 8892 O  O   . HOH M 4 .   ? 36.837  4.891   14.526  1.00 28.42 ? 522 HOH A O   1 
HETATM 8893 O  O   . HOH M 4 .   ? 29.700  9.825   33.861  1.00 28.30 ? 523 HOH A O   1 
HETATM 8894 O  O   . HOH M 4 .   ? 26.228  11.981  6.512   1.00 24.75 ? 524 HOH A O   1 
HETATM 8895 O  O   . HOH M 4 .   ? 39.665  -13.705 7.846   1.00 34.49 ? 525 HOH A O   1 
HETATM 8896 O  O   . HOH M 4 .   ? 24.954  13.881  33.469  1.00 30.00 ? 526 HOH A O   1 
HETATM 8897 O  O   . HOH M 4 .   ? 43.405  -9.631  11.620  1.00 23.71 ? 527 HOH A O   1 
HETATM 8898 O  O   . HOH M 4 .   ? 12.011  7.539   8.627   1.00 9.57  ? 528 HOH A O   1 
HETATM 8899 O  O   . HOH M 4 .   ? 29.007  -15.075 16.973  1.00 16.29 ? 529 HOH A O   1 
HETATM 8900 O  O   . HOH M 4 .   ? 17.211  -3.567  -8.235  1.00 31.25 ? 530 HOH A O   1 
HETATM 8901 O  O   . HOH M 4 .   ? 11.757  -15.425 8.358   1.00 21.72 ? 531 HOH A O   1 
HETATM 8902 O  O   . HOH M 4 .   ? 20.521  15.465  2.033   1.00 30.43 ? 532 HOH A O   1 
HETATM 8903 O  O   . HOH M 4 .   ? 44.643  -1.655  14.956  1.00 30.62 ? 533 HOH A O   1 
HETATM 8904 O  O   . HOH M 4 .   ? 11.003  11.162  8.032   1.00 9.19  ? 534 HOH A O   1 
HETATM 8905 O  O   . HOH M 4 .   ? 13.730  -15.934 27.094  1.00 31.72 ? 535 HOH A O   1 
HETATM 8906 O  O   . HOH M 4 .   ? 32.152  -16.895 17.183  1.00 35.06 ? 536 HOH A O   1 
HETATM 8907 O  O   . HOH M 4 .   ? 17.745  9.557   0.136   1.00 9.54  ? 537 HOH A O   1 
HETATM 8908 O  O   . HOH M 4 .   ? 13.581  -12.593 20.780  1.00 15.03 ? 538 HOH A O   1 
HETATM 8909 O  O   . HOH M 4 .   ? 39.015  1.972   -6.033  1.00 24.86 ? 539 HOH A O   1 
HETATM 8910 O  O   . HOH M 4 .   ? 21.016  -2.792  -5.278  1.00 21.39 ? 540 HOH A O   1 
HETATM 8911 O  O   . HOH M 4 .   ? 21.005  -4.568  32.333  1.00 29.97 ? 541 HOH A O   1 
HETATM 8912 O  O   . HOH M 4 .   ? 25.818  -18.059 17.404  1.00 20.24 ? 542 HOH A O   1 
HETATM 8913 O  O   . HOH M 4 .   ? 17.573  7.966   19.791  1.00 28.57 ? 543 HOH A O   1 
HETATM 8914 O  O   . HOH M 4 .   ? 14.785  7.214   21.014  1.00 24.23 ? 544 HOH A O   1 
HETATM 8915 O  O   . HOH M 4 .   ? 41.615  7.040   3.225   1.00 30.82 ? 545 HOH A O   1 
HETATM 8916 O  O   . HOH M 4 .   ? 11.617  7.977   1.620   1.00 10.03 ? 546 HOH A O   1 
HETATM 8917 O  O   . HOH M 4 .   ? 23.442  3.235   -1.991  1.00 13.85 ? 547 HOH A O   1 
HETATM 8918 O  O   . HOH M 4 .   ? 45.281  1.367   22.464  1.00 37.80 ? 548 HOH A O   1 
HETATM 8919 O  O   . HOH M 4 .   ? 9.160   -10.985 14.085  1.00 26.88 ? 549 HOH A O   1 
HETATM 8920 O  O   . HOH M 4 .   ? 29.787  12.890  9.943   1.00 38.84 ? 550 HOH A O   1 
HETATM 8921 O  O   . HOH M 4 .   ? 8.918   3.943   2.643   1.00 11.77 ? 551 HOH A O   1 
HETATM 8922 O  O   . HOH M 4 .   ? 46.057  -9.450  16.728  1.00 33.22 ? 552 HOH A O   1 
HETATM 8923 O  O   . HOH M 4 .   ? 9.043   2.090   -8.159  1.00 36.90 ? 553 HOH A O   1 
HETATM 8924 O  O   . HOH M 4 .   ? 15.837  4.579   21.606  1.00 21.10 ? 554 HOH A O   1 
HETATM 8925 O  O   . HOH M 4 .   ? 17.768  9.982   21.933  1.00 32.15 ? 555 HOH A O   1 
HETATM 8926 O  O   . HOH M 4 .   ? 9.663   -5.519  -1.542  1.00 37.50 ? 556 HOH A O   1 
HETATM 8927 O  O   . HOH M 4 .   ? 14.259  4.403   -4.021  1.00 19.25 ? 557 HOH A O   1 
HETATM 8928 O  O   . HOH M 4 .   ? 14.479  -12.405 29.419  1.00 15.96 ? 558 HOH A O   1 
HETATM 8929 O  O   . HOH M 4 .   ? 25.571  -16.038 6.615   1.00 10.72 ? 559 HOH A O   1 
HETATM 8930 O  O   . HOH M 4 .   ? 14.826  -15.893 14.980  1.00 22.54 ? 560 HOH A O   1 
HETATM 8931 O  O   . HOH M 4 .   ? 7.678   9.046   14.150  1.00 15.44 ? 561 HOH A O   1 
HETATM 8932 O  O   . HOH M 4 .   ? 16.687  10.929  -3.263  1.00 20.04 ? 562 HOH A O   1 
HETATM 8933 O  O   . HOH M 4 .   ? 9.622   -2.603  10.383  1.00 18.47 ? 563 HOH A O   1 
HETATM 8934 O  O   . HOH M 4 .   ? 44.855  -4.208  15.607  1.00 31.41 ? 564 HOH A O   1 
HETATM 8935 O  O   . HOH M 4 .   ? 38.213  -13.518 5.635   1.00 24.37 ? 565 HOH A O   1 
HETATM 8936 O  O   . HOH M 4 .   ? 26.004  -18.520 20.587  1.00 18.64 ? 566 HOH A O   1 
HETATM 8937 O  O   . HOH M 4 .   ? 27.483  -15.877 -5.634  1.00 26.08 ? 567 HOH A O   1 
HETATM 8938 O  O   . HOH M 4 .   ? 37.974  10.043  -5.039  1.00 27.26 ? 568 HOH A O   1 
HETATM 8939 O  O   . HOH M 4 .   ? 38.376  -15.604 12.367  1.00 24.17 ? 569 HOH A O   1 
HETATM 8940 O  O   . HOH M 4 .   ? 15.173  -17.531 19.207  1.00 35.80 ? 570 HOH A O   1 
HETATM 8941 O  O   . HOH M 4 .   ? 35.184  10.205  10.245  1.00 26.35 ? 571 HOH A O   1 
HETATM 8942 O  O   . HOH M 4 .   ? 24.009  11.946  0.503   1.00 23.16 ? 572 HOH A O   1 
HETATM 8943 O  O   . HOH M 4 .   ? 18.132  5.478   20.707  1.00 18.91 ? 573 HOH A O   1 
HETATM 8944 O  O   . HOH M 4 .   ? 23.937  -21.208 26.548  1.00 25.93 ? 574 HOH A O   1 
HETATM 8945 O  O   . HOH M 4 .   ? 17.574  -16.633 -8.021  1.00 34.01 ? 575 HOH A O   1 
HETATM 8946 O  O   . HOH M 4 .   ? 42.457  2.634   5.219   1.00 35.03 ? 576 HOH A O   1 
HETATM 8947 O  O   . HOH M 4 .   ? 14.281  -1.994  28.873  1.00 19.60 ? 577 HOH A O   1 
HETATM 8948 O  O   . HOH M 4 .   ? 39.101  3.756   19.653  1.00 26.07 ? 578 HOH A O   1 
HETATM 8949 O  O   . HOH M 4 .   ? 25.700  -9.848  28.969  1.00 27.36 ? 579 HOH A O   1 
HETATM 8950 O  O   . HOH M 4 .   ? 44.108  -10.058 8.157   1.00 23.17 ? 580 HOH A O   1 
HETATM 8951 O  O   . HOH M 4 .   ? 8.034   -2.372  14.883  1.00 30.92 ? 581 HOH A O   1 
HETATM 8952 O  O   . HOH M 4 .   ? 23.096  12.416  14.952  1.00 30.70 ? 582 HOH A O   1 
HETATM 8953 O  O   . HOH M 4 .   ? 11.661  2.351   -6.795  1.00 38.99 ? 583 HOH A O   1 
HETATM 8954 O  O   . HOH M 4 .   ? 14.982  -14.553 19.149  1.00 14.67 ? 584 HOH A O   1 
HETATM 8955 O  O   . HOH M 4 .   ? 32.342  7.689   30.895  1.00 18.97 ? 585 HOH A O   1 
HETATM 8956 O  O   . HOH M 4 .   ? 23.998  -22.255 18.540  1.00 35.81 ? 586 HOH A O   1 
HETATM 8957 O  O   . HOH M 4 .   ? 31.550  -18.981 4.255   1.00 21.49 ? 587 HOH A O   1 
HETATM 8958 O  O   . HOH M 4 .   ? 13.364  5.072   -0.519  1.00 18.67 ? 588 HOH A O   1 
HETATM 8959 O  O   . HOH M 4 .   ? 10.159  3.080   22.438  1.00 24.98 ? 589 HOH A O   1 
HETATM 8960 O  O   . HOH M 4 .   ? 27.252  -5.458  -5.196  1.00 22.57 ? 590 HOH A O   1 
HETATM 8961 O  O   . HOH M 4 .   ? 11.518  9.617   -2.217  1.00 27.38 ? 591 HOH A O   1 
HETATM 8962 O  O   . HOH M 4 .   ? 27.800  -4.818  31.336  1.00 29.98 ? 592 HOH A O   1 
HETATM 8963 O  O   . HOH M 4 .   ? 43.893  1.773   2.899   1.00 29.84 ? 593 HOH A O   1 
HETATM 8964 O  O   . HOH M 4 .   ? 15.646  13.953  -0.424  1.00 24.41 ? 594 HOH A O   1 
HETATM 8965 O  O   . HOH M 4 .   ? 22.046  -19.145 15.094  1.00 30.35 ? 595 HOH A O   1 
HETATM 8966 O  O   . HOH M 4 .   ? 20.878  17.778  7.656   1.00 30.71 ? 596 HOH A O   1 
HETATM 8967 O  O   . HOH M 4 .   ? 12.414  4.445   22.135  1.00 25.05 ? 597 HOH A O   1 
HETATM 8968 O  O   . HOH M 4 .   ? 23.882  14.832  4.689   1.00 22.70 ? 598 HOH A O   1 
HETATM 8969 O  O   . HOH M 4 .   ? 35.844  14.990  8.323   1.00 38.41 ? 599 HOH A O   1 
HETATM 8970 O  O   . HOH M 4 .   ? 32.054  -18.511 7.020   1.00 24.59 ? 600 HOH A O   1 
HETATM 8971 O  O   . HOH M 4 .   ? 7.397   -2.066  -0.682  1.00 22.23 ? 601 HOH A O   1 
HETATM 8972 O  O   . HOH M 4 .   ? 45.085  -6.851  13.171  1.00 36.47 ? 602 HOH A O   1 
HETATM 8973 O  O   . HOH M 4 .   ? 12.965  -14.307 12.973  1.00 26.47 ? 603 HOH A O   1 
HETATM 8974 O  O   . HOH M 4 .   ? 14.991  -13.646 16.678  1.00 13.51 ? 604 HOH A O   1 
HETATM 8975 O  O   . HOH M 4 .   ? 24.133  -21.398 -3.450  1.00 33.19 ? 605 HOH A O   1 
HETATM 8976 O  O   . HOH M 4 .   ? 33.994  16.008  5.996   1.00 42.74 ? 606 HOH A O   1 
HETATM 8977 O  O   . HOH M 4 .   ? 6.153   -2.995  13.099  1.00 16.83 ? 607 HOH A O   1 
HETATM 8978 O  O   . HOH M 4 .   ? 37.369  7.761   9.599   1.00 30.22 ? 608 HOH A O   1 
HETATM 8979 O  O   . HOH M 4 .   ? 17.689  -6.263  33.651  1.00 29.79 ? 609 HOH A O   1 
HETATM 8980 O  O   . HOH M 4 .   ? 36.505  1.607   30.628  1.00 32.92 ? 610 HOH A O   1 
HETATM 8981 O  O   . HOH M 4 .   ? 24.889  15.987  2.234   1.00 27.19 ? 611 HOH A O   1 
HETATM 8982 O  O   . HOH M 4 .   ? 7.195   -0.726  8.198   1.00 25.99 ? 612 HOH A O   1 
HETATM 8983 O  O   . HOH M 4 .   ? 24.001  -15.363 -11.791 1.00 30.27 ? 613 HOH A O   1 
HETATM 8984 O  O   . HOH M 4 .   ? 29.462  9.533   14.066  1.00 36.22 ? 614 HOH A O   1 
HETATM 8985 O  O   . HOH M 4 .   ? 19.918  -7.461  32.301  1.00 27.01 ? 615 HOH A O   1 
HETATM 8986 O  O   . HOH M 4 .   ? 28.585  -9.247  30.597  1.00 28.69 ? 616 HOH A O   1 
HETATM 8987 O  O   . HOH M 4 .   ? 20.070  -19.267 28.872  1.00 34.49 ? 617 HOH A O   1 
HETATM 8988 O  O   . HOH M 4 .   ? 25.258  10.718  -2.885  1.00 38.28 ? 618 HOH A O   1 
HETATM 8989 O  O   . HOH M 4 .   ? 14.589  -14.038 2.364   1.00 34.47 ? 619 HOH A O   1 
HETATM 8990 O  O   . HOH M 4 .   ? 18.113  -15.745 33.999  1.00 28.26 ? 620 HOH A O   1 
HETATM 8991 O  O   . HOH M 4 .   ? 7.423   -2.155  -13.630 1.00 43.14 ? 621 HOH A O   1 
HETATM 8992 O  O   . HOH M 4 .   ? 23.681  -19.566 16.691  1.00 28.55 ? 622 HOH A O   1 
HETATM 8993 O  O   . HOH M 4 .   ? 29.823  6.839   12.589  1.00 30.66 ? 623 HOH A O   1 
HETATM 8994 O  O   . HOH M 4 .   ? 7.861   -12.948 -1.307  1.00 29.43 ? 624 HOH A O   1 
HETATM 8995 O  O   . HOH M 4 .   ? 33.774  -3.894  32.198  1.00 32.29 ? 625 HOH A O   1 
HETATM 8996 O  O   . HOH M 4 .   ? 8.266   -5.219  -6.563  1.00 36.47 ? 626 HOH A O   1 
HETATM 8997 O  O   . HOH M 4 .   ? 8.049   -6.814  31.986  1.00 45.12 ? 627 HOH A O   1 
HETATM 8998 O  O   . HOH M 4 .   ? 11.235  -1.507  28.072  1.00 38.67 ? 628 HOH A O   1 
HETATM 8999 O  O   . HOH M 4 .   ? 24.256  -11.857 30.215  1.00 30.24 ? 629 HOH A O   1 
HETATM 9000 O  O   . HOH M 4 .   ? 45.632  1.824   8.165   1.00 36.66 ? 630 HOH A O   1 
HETATM 9001 O  O   . HOH M 4 .   ? 28.804  -18.725 20.568  1.00 20.52 ? 631 HOH A O   1 
HETATM 9002 O  O   . HOH M 4 .   ? 45.906  1.986   25.839  1.00 34.45 ? 632 HOH A O   1 
HETATM 9003 O  O   . HOH M 4 .   ? 30.139  -17.697 18.486  1.00 28.84 ? 633 HOH A O   1 
HETATM 9004 O  O   . HOH M 4 .   ? 35.915  -16.276 13.405  1.00 36.97 ? 634 HOH A O   1 
HETATM 9005 O  O   . HOH M 4 .   ? 6.537   6.714   17.932  1.00 25.12 ? 635 HOH A O   1 
HETATM 9006 O  O   . HOH M 4 .   ? 39.822  2.680   16.998  1.00 36.73 ? 636 HOH A O   1 
HETATM 9007 O  O   . HOH M 4 .   ? 13.156  13.542  -1.988  1.00 22.56 ? 637 HOH A O   1 
HETATM 9008 O  O   . HOH M 4 .   ? 20.580  -0.082  -7.059  1.00 48.14 ? 638 HOH A O   1 
HETATM 9009 O  O   . HOH M 4 .   ? 26.021  14.294  36.215  1.00 41.23 ? 639 HOH A O   1 
HETATM 9010 O  O   . HOH M 4 .   ? 16.822  2.169   -7.968  1.00 31.65 ? 640 HOH A O   1 
HETATM 9011 O  O   . HOH M 4 .   ? 7.279   -5.529  5.092   1.00 24.77 ? 641 HOH A O   1 
HETATM 9012 O  O   . HOH M 4 .   ? 45.528  -0.073  6.286   1.00 30.84 ? 642 HOH A O   1 
HETATM 9013 O  O   . HOH M 4 .   ? 34.016  8.967   12.509  1.00 33.62 ? 643 HOH A O   1 
HETATM 9014 O  O   . HOH M 4 .   ? 10.061  3.935   -2.627  1.00 32.43 ? 644 HOH A O   1 
HETATM 9015 O  O   . HOH M 4 .   ? 33.653  -17.721 2.921   1.00 29.61 ? 645 HOH A O   1 
HETATM 9016 O  O   . HOH M 4 .   ? 7.906   6.508   15.471  1.00 15.32 ? 646 HOH A O   1 
HETATM 9017 O  O   . HOH M 4 .   ? 10.482  -3.869  30.296  1.00 32.33 ? 647 HOH A O   1 
HETATM 9018 O  O   . HOH M 4 .   ? 13.818  21.289  11.395  1.00 27.58 ? 648 HOH A O   1 
HETATM 9019 O  O   . HOH M 4 .   ? 51.135  -9.190  27.062  1.00 39.99 ? 649 HOH A O   1 
HETATM 9020 O  O   . HOH M 4 .   ? 27.194  -18.327 14.848  1.00 34.40 ? 650 HOH A O   1 
HETATM 9021 O  O   . HOH M 4 .   ? 23.366  14.690  0.363   1.00 38.41 ? 651 HOH A O   1 
HETATM 9022 O  O   . HOH M 4 .   ? 26.807  13.297  8.670   1.00 32.39 ? 652 HOH A O   1 
HETATM 9023 O  O   . HOH M 4 .   ? 23.413  -10.184 32.546  1.00 26.00 ? 653 HOH A O   1 
HETATM 9024 O  O   . HOH M 4 .   ? 15.153  15.050  13.522  1.00 26.25 ? 654 HOH A O   1 
HETATM 9025 O  O   . HOH M 4 .   ? 23.591  -4.122  -5.642  1.00 37.56 ? 655 HOH A O   1 
HETATM 9026 O  O   . HOH M 4 .   ? 16.415  -16.365 7.946   1.00 29.17 ? 656 HOH A O   1 
HETATM 9027 O  O   . HOH M 4 .   ? 30.069  -18.019 -2.645  1.00 27.01 ? 657 HOH A O   1 
HETATM 9028 O  O   . HOH M 4 .   ? 5.845   -0.469  -2.629  1.00 26.20 ? 658 HOH A O   1 
HETATM 9029 O  O   . HOH M 4 .   ? 24.067  -2.949  33.083  1.00 27.40 ? 659 HOH A O   1 
HETATM 9030 O  O   . HOH M 4 .   ? 24.776  -14.365 30.960  1.00 32.33 ? 660 HOH A O   1 
HETATM 9031 O  O   . HOH M 4 .   ? 38.758  -4.501  30.325  1.00 32.63 ? 661 HOH A O   1 
HETATM 9032 O  O   . HOH M 4 .   ? 36.716  13.531  -0.950  1.00 30.38 ? 662 HOH A O   1 
HETATM 9033 O  O   . HOH M 4 .   ? 32.380  -15.387 28.171  1.00 32.42 ? 663 HOH A O   1 
HETATM 9034 O  O   . HOH M 4 .   ? 21.675  2.532   -6.965  1.00 33.74 ? 664 HOH A O   1 
HETATM 9035 O  O   . HOH M 4 .   ? 24.529  -5.318  31.348  1.00 34.74 ? 665 HOH A O   1 
HETATM 9036 O  O   . HOH M 4 .   ? 20.077  21.710  9.383   1.00 35.52 ? 666 HOH A O   1 
HETATM 9037 O  O   . HOH M 4 .   ? 19.926  7.547   -4.505  1.00 33.71 ? 667 HOH A O   1 
HETATM 9038 O  O   . HOH M 4 .   ? 8.089   -4.746  9.275   1.00 24.66 ? 668 HOH A O   1 
HETATM 9039 O  O   . HOH M 4 .   ? 21.342  16.016  4.974   1.00 20.81 ? 669 HOH A O   1 
HETATM 9040 O  O   . HOH M 4 .   ? 17.259  13.477  -2.122  1.00 31.13 ? 670 HOH A O   1 
HETATM 9041 O  O   . HOH M 4 .   ? 13.560  -12.917 23.575  1.00 30.83 ? 671 HOH A O   1 
HETATM 9042 O  O   . HOH M 4 .   ? 19.360  -11.226 33.782  1.00 23.03 ? 672 HOH A O   1 
HETATM 9043 O  O   . HOH M 4 .   ? 11.956  5.374   -4.046  1.00 29.19 ? 673 HOH A O   1 
HETATM 9044 O  O   . HOH M 4 .   ? 27.103  -8.809  -13.287 1.00 31.70 ? 674 HOH A O   1 
HETATM 9045 O  O   . HOH M 4 .   ? 11.384  -13.079 25.910  1.00 31.98 ? 675 HOH A O   1 
HETATM 9046 O  O   . HOH M 4 .   ? 21.090  11.756  -2.701  1.00 27.47 ? 676 HOH A O   1 
HETATM 9047 O  O   . HOH M 4 .   ? 36.706  -4.182  34.676  1.00 38.21 ? 677 HOH A O   1 
HETATM 9048 O  O   . HOH M 4 .   ? 15.229  4.452   -6.591  1.00 29.65 ? 678 HOH A O   1 
HETATM 9049 O  O   . HOH M 4 .   ? 10.739  -15.075 30.169  1.00 26.95 ? 679 HOH A O   1 
HETATM 9050 O  O   . HOH M 4 .   ? 12.400  -15.828 11.014  1.00 30.40 ? 680 HOH A O   1 
HETATM 9051 O  O   . HOH M 4 .   ? 25.222  -18.462 30.219  1.00 33.68 ? 681 HOH A O   1 
HETATM 9052 O  O   . HOH M 4 .   ? 25.460  13.574  11.056  1.00 34.09 ? 682 HOH A O   1 
HETATM 9053 O  O   . HOH M 4 .   ? 13.661  -17.053 7.249   1.00 27.21 ? 683 HOH A O   1 
HETATM 9054 O  O   . HOH M 4 .   ? 19.308  10.294  -4.356  1.00 22.83 ? 684 HOH A O   1 
HETATM 9055 O  O   . HOH M 4 .   ? 22.949  16.394  8.820   1.00 33.09 ? 685 HOH A O   1 
HETATM 9056 O  O   . HOH M 4 .   ? 37.999  -11.334 26.936  1.00 35.92 ? 686 HOH A O   1 
HETATM 9057 O  O   . HOH M 4 .   ? 33.166  -18.250 27.772  1.00 35.94 ? 687 HOH A O   1 
HETATM 9058 O  O   . HOH M 4 .   ? 27.516  13.177  12.999  1.00 34.42 ? 688 HOH A O   1 
HETATM 9059 O  O   . HOH M 4 .   ? 31.944  -19.997 -1.394  1.00 28.38 ? 689 HOH A O   1 
HETATM 9060 O  O   . HOH M 4 .   ? 18.874  6.575   -6.861  1.00 31.70 ? 690 HOH A O   1 
HETATM 9061 O  O   . HOH M 4 .   ? 16.850  18.945  -0.123  1.00 34.24 ? 691 HOH A O   1 
HETATM 9062 O  O   . HOH M 4 .   ? 28.217  -17.758 30.469  1.00 37.65 ? 692 HOH A O   1 
HETATM 9063 O  O   . HOH N 4 .   ? -9.965  2.306   -15.934 1.00 27.10 ? 401 HOH B O   1 
HETATM 9064 O  O   . HOH N 4 .   ? 8.923   3.045   20.020  1.00 29.41 ? 402 HOH B O   1 
HETATM 9065 O  O   . HOH N 4 .   ? 5.491   -11.200 4.926   1.00 31.52 ? 403 HOH B O   1 
HETATM 9066 O  O   . HOH N 4 .   ? -0.292  16.649  -11.289 1.00 25.18 ? 404 HOH B O   1 
HETATM 9067 O  O   . HOH N 4 .   ? -29.391 2.334   6.001   1.00 23.53 ? 405 HOH B O   1 
HETATM 9068 O  O   . HOH N 4 .   ? -4.869  -19.991 17.973  1.00 32.54 ? 406 HOH B O   1 
HETATM 9069 O  O   . HOH N 4 .   ? -10.769 2.895   -2.614  1.00 16.85 ? 407 HOH B O   1 
HETATM 9070 O  O   . HOH N 4 .   ? -3.773  13.789  -7.070  1.00 28.84 ? 408 HOH B O   1 
HETATM 9071 O  O   . HOH N 4 .   ? -21.515 -9.910  10.041  1.00 32.26 ? 409 HOH B O   1 
HETATM 9072 O  O   . HOH N 4 .   ? -15.061 12.074  20.615  1.00 29.65 ? 410 HOH B O   1 
HETATM 9073 O  O   . HOH N 4 .   ? -27.311 3.534   -10.496 1.00 27.22 ? 411 HOH B O   1 
HETATM 9074 O  O   . HOH N 4 .   ? 3.495   -1.995  22.538  1.00 33.21 ? 412 HOH B O   1 
HETATM 9075 O  O   . HOH N 4 .   ? -2.701  5.107   3.900   1.00 8.80  ? 413 HOH B O   1 
HETATM 9076 O  O   . HOH N 4 .   ? 6.649   -11.355 17.378  1.00 26.78 ? 414 HOH B O   1 
HETATM 9077 O  O   . HOH N 4 .   ? -13.565 20.107  14.319  1.00 35.57 ? 415 HOH B O   1 
HETATM 9078 O  O   . HOH N 4 .   ? -30.870 2.128   10.372  1.00 42.10 ? 416 HOH B O   1 
HETATM 9079 O  O   . HOH N 4 .   ? -21.920 1.698   18.554  1.00 22.83 ? 417 HOH B O   1 
HETATM 9080 O  O   . HOH N 4 .   ? -26.834 -7.749  10.497  1.00 36.84 ? 418 HOH B O   1 
HETATM 9081 O  O   . HOH N 4 .   ? -27.179 -3.795  -5.802  1.00 32.49 ? 419 HOH B O   1 
HETATM 9082 O  O   . HOH N 4 .   ? -19.719 -7.539  -11.771 1.00 25.87 ? 420 HOH B O   1 
HETATM 9083 O  O   . HOH N 4 .   ? -17.269 10.849  4.275   1.00 29.46 ? 421 HOH B O   1 
HETATM 9084 O  O   . HOH N 4 .   ? -7.779  4.657   -0.194  1.00 17.43 ? 422 HOH B O   1 
HETATM 9085 O  O   . HOH N 4 .   ? 6.317   16.735  0.800   1.00 22.46 ? 423 HOH B O   1 
HETATM 9086 O  O   . HOH N 4 .   ? -2.527  -8.360  -9.249  1.00 24.54 ? 424 HOH B O   1 
HETATM 9087 O  O   . HOH N 4 .   ? 5.766   -9.350  13.479  1.00 16.80 ? 425 HOH B O   1 
HETATM 9088 O  O   . HOH N 4 .   ? -27.689 6.702   19.642  1.00 38.73 ? 426 HOH B O   1 
HETATM 9089 O  O   . HOH N 4 .   ? -18.643 8.083   -13.869 1.00 28.33 ? 427 HOH B O   1 
HETATM 9090 O  O   . HOH N 4 .   ? -4.498  11.258  -15.063 1.00 12.13 ? 428 HOH B O   1 
HETATM 9091 O  O   . HOH N 4 .   ? -16.455 -12.174 25.766  1.00 22.23 ? 429 HOH B O   1 
HETATM 9092 O  O   . HOH N 4 .   ? 3.208   1.254   -12.713 1.00 31.52 ? 430 HOH B O   1 
HETATM 9093 O  O   . HOH N 4 .   ? -4.222  -17.900 22.576  1.00 21.49 ? 431 HOH B O   1 
HETATM 9094 O  O   . HOH N 4 .   ? 5.173   6.314   0.967   1.00 10.56 ? 432 HOH B O   1 
HETATM 9095 O  O   . HOH N 4 .   ? -26.399 8.985   16.319  1.00 31.08 ? 433 HOH B O   1 
HETATM 9096 O  O   . HOH N 4 .   ? -14.639 -13.431 24.033  1.00 27.16 ? 434 HOH B O   1 
HETATM 9097 O  O   . HOH N 4 .   ? -7.612  -7.448  28.492  1.00 31.37 ? 435 HOH B O   1 
HETATM 9098 O  O   . HOH N 4 .   ? 7.827   11.860  14.728  1.00 20.83 ? 436 HOH B O   1 
HETATM 9099 O  O   . HOH N 4 .   ? 3.177   15.606  -5.205  1.00 34.46 ? 437 HOH B O   1 
HETATM 9100 O  O   . HOH N 4 .   ? -8.560  15.088  -2.340  1.00 44.75 ? 438 HOH B O   1 
HETATM 9101 O  O   . HOH N 4 .   ? -11.211 7.573   1.210   1.00 20.45 ? 439 HOH B O   1 
HETATM 9102 O  O   . HOH N 4 .   ? 4.349   3.804   20.720  1.00 34.80 ? 440 HOH B O   1 
HETATM 9103 O  O   . HOH N 4 .   ? -19.188 -1.091  -16.466 1.00 27.43 ? 441 HOH B O   1 
HETATM 9104 O  O   . HOH N 4 .   ? -17.328 -16.857 -6.007  1.00 25.67 ? 442 HOH B O   1 
HETATM 9105 O  O   . HOH N 4 .   ? -12.240 -13.610 -11.327 1.00 15.09 ? 443 HOH B O   1 
HETATM 9106 O  O   . HOH N 4 .   ? -20.210 -11.808 8.149   1.00 25.68 ? 444 HOH B O   1 
HETATM 9107 O  O   . HOH N 4 .   ? -4.212  16.140  -11.370 1.00 12.87 ? 445 HOH B O   1 
HETATM 9108 O  O   . HOH N 4 .   ? -14.050 -14.974 28.402  1.00 16.08 ? 446 HOH B O   1 
HETATM 9109 O  O   . HOH N 4 .   ? -27.202 -10.158 1.588   1.00 23.18 ? 447 HOH B O   1 
HETATM 9110 O  O   . HOH N 4 .   ? -17.512 -12.583 3.429   1.00 20.62 ? 448 HOH B O   1 
HETATM 9111 O  O   . HOH N 4 .   ? 4.182   14.749  1.680   1.00 20.62 ? 449 HOH B O   1 
HETATM 9112 O  O   . HOH N 4 .   ? -3.836  12.614  -18.372 1.00 14.27 ? 450 HOH B O   1 
HETATM 9113 O  O   . HOH N 4 .   ? -16.376 -8.442  30.439  1.00 31.94 ? 451 HOH B O   1 
HETATM 9114 O  O   . HOH N 4 .   ? -15.664 16.348  -8.375  1.00 28.87 ? 452 HOH B O   1 
HETATM 9115 O  O   . HOH N 4 .   ? 1.641   6.508   -8.250  1.00 18.92 ? 453 HOH B O   1 
HETATM 9116 O  O   . HOH N 4 .   ? 2.607   -13.258 15.918  1.00 17.11 ? 454 HOH B O   1 
HETATM 9117 O  O   . HOH N 4 .   ? 3.684   -2.129  13.991  1.00 12.66 ? 455 HOH B O   1 
HETATM 9118 O  O   . HOH N 4 .   ? -3.423  19.118  -20.214 1.00 31.04 ? 456 HOH B O   1 
HETATM 9119 O  O   . HOH N 4 .   ? -8.973  8.538   19.780  1.00 32.61 ? 457 HOH B O   1 
HETATM 9120 O  O   . HOH N 4 .   ? -13.650 7.329   -15.745 1.00 18.25 ? 458 HOH B O   1 
HETATM 9121 O  O   . HOH N 4 .   ? -21.138 -5.013  21.809  1.00 31.13 ? 459 HOH B O   1 
HETATM 9122 O  O   . HOH N 4 .   ? 4.426   6.430   14.080  1.00 10.11 ? 460 HOH B O   1 
HETATM 9123 O  O   . HOH N 4 .   ? -21.666 -8.812  -8.396  1.00 15.86 ? 461 HOH B O   1 
HETATM 9124 O  O   . HOH N 4 .   ? 0.843   18.203  -13.926 1.00 22.08 ? 462 HOH B O   1 
HETATM 9125 O  O   . HOH N 4 .   ? -18.323 -8.077  15.965  1.00 16.63 ? 463 HOH B O   1 
HETATM 9126 O  O   . HOH N 4 .   ? 7.803   21.444  7.814   1.00 9.57  ? 464 HOH B O   1 
HETATM 9127 O  O   . HOH N 4 .   ? -5.792  -12.547 11.874  1.00 15.20 ? 465 HOH B O   1 
HETATM 9128 O  O   . HOH N 4 .   ? -21.399 11.302  6.294   1.00 31.67 ? 466 HOH B O   1 
HETATM 9129 O  O   . HOH N 4 .   ? 0.957   0.638   -16.139 1.00 26.15 ? 467 HOH B O   1 
HETATM 9130 O  O   . HOH N 4 .   ? -2.905  -5.383  -4.118  1.00 8.27  ? 468 HOH B O   1 
HETATM 9131 O  O   . HOH N 4 .   ? -20.067 -12.201 -2.370  1.00 24.45 ? 469 HOH B O   1 
HETATM 9132 O  O   . HOH N 4 .   ? -31.828 5.139   -7.566  1.00 19.23 ? 470 HOH B O   1 
HETATM 9133 O  O   . HOH N 4 .   ? -26.786 9.062   -2.846  1.00 25.48 ? 471 HOH B O   1 
HETATM 9134 O  O   . HOH N 4 .   ? -6.695  11.083  -19.703 1.00 10.68 ? 472 HOH B O   1 
HETATM 9135 O  O   . HOH N 4 .   ? -30.069 -4.576  -0.730  1.00 18.86 ? 473 HOH B O   1 
HETATM 9136 O  O   . HOH N 4 .   ? 4.664   -5.933  8.985   1.00 18.25 ? 474 HOH B O   1 
HETATM 9137 O  O   . HOH N 4 .   ? -16.704 -16.836 16.688  1.00 28.36 ? 475 HOH B O   1 
HETATM 9138 O  O   . HOH N 4 .   ? -11.733 -5.041  -9.721  1.00 20.38 ? 476 HOH B O   1 
HETATM 9139 O  O   . HOH N 4 .   ? 3.645   3.436   -2.446  1.00 15.45 ? 477 HOH B O   1 
HETATM 9140 O  O   . HOH N 4 .   ? 5.895   12.267  -4.379  1.00 14.80 ? 478 HOH B O   1 
HETATM 9141 O  O   . HOH N 4 .   ? -3.025  -12.831 15.442  1.00 27.88 ? 479 HOH B O   1 
HETATM 9142 O  O   . HOH N 4 .   ? 12.529  14.552  2.303   1.00 12.89 ? 480 HOH B O   1 
HETATM 9143 O  O   . HOH N 4 .   ? -20.432 -0.935  -14.100 1.00 31.32 ? 481 HOH B O   1 
HETATM 9144 O  O   . HOH N 4 .   ? 9.192   7.295   8.452   1.00 17.25 ? 482 HOH B O   1 
HETATM 9145 O  O   . HOH N 4 .   ? -27.097 -6.293  6.738   1.00 21.19 ? 483 HOH B O   1 
HETATM 9146 O  O   . HOH N 4 .   ? 5.336   5.481   7.643   1.00 10.75 ? 484 HOH B O   1 
HETATM 9147 O  O   . HOH N 4 .   ? 11.419  14.464  -0.082  1.00 19.69 ? 485 HOH B O   1 
HETATM 9148 O  O   . HOH N 4 .   ? -18.090 9.428   -2.708  1.00 20.70 ? 486 HOH B O   1 
HETATM 9149 O  O   . HOH N 4 .   ? -26.811 -7.181  -1.553  1.00 20.27 ? 487 HOH B O   1 
HETATM 9150 O  O   . HOH N 4 .   ? -20.284 -12.120 1.070   1.00 31.15 ? 488 HOH B O   1 
HETATM 9151 O  O   . HOH N 4 .   ? -6.118  -18.296 -2.185  1.00 26.12 ? 489 HOH B O   1 
HETATM 9152 O  O   . HOH N 4 .   ? -16.544 -3.623  20.371  1.00 20.75 ? 490 HOH B O   1 
HETATM 9153 O  O   . HOH N 4 .   ? -24.623 -2.524  -6.378  1.00 14.68 ? 491 HOH B O   1 
HETATM 9154 O  O   . HOH N 4 .   ? -0.533  18.029  0.541   1.00 36.68 ? 492 HOH B O   1 
HETATM 9155 O  O   . HOH N 4 .   ? -13.917 0.409   14.956  1.00 11.61 ? 493 HOH B O   1 
HETATM 9156 O  O   . HOH N 4 .   ? -16.997 -10.805 1.273   1.00 12.48 ? 494 HOH B O   1 
HETATM 9157 O  O   . HOH N 4 .   ? 1.636   8.974   -6.972  1.00 15.91 ? 495 HOH B O   1 
HETATM 9158 O  O   . HOH N 4 .   ? 1.396   14.427  -11.221 1.00 17.51 ? 496 HOH B O   1 
HETATM 9159 O  O   . HOH N 4 .   ? -5.922  11.304  20.566  1.00 25.30 ? 497 HOH B O   1 
HETATM 9160 O  O   . HOH N 4 .   ? 7.266   -11.207 24.120  1.00 30.54 ? 498 HOH B O   1 
HETATM 9161 O  O   . HOH N 4 .   ? -32.083 -6.629  5.990   1.00 26.26 ? 499 HOH B O   1 
HETATM 9162 O  O   . HOH N 4 .   ? -19.597 -16.113 10.397  1.00 29.87 ? 500 HOH B O   1 
HETATM 9163 O  O   . HOH N 4 .   ? -20.940 -11.271 5.724   1.00 32.79 ? 501 HOH B O   1 
HETATM 9164 O  O   . HOH N 4 .   ? -20.382 -9.508  15.014  1.00 17.82 ? 502 HOH B O   1 
HETATM 9165 O  O   . HOH N 4 .   ? 4.588   17.222  3.674   1.00 24.14 ? 503 HOH B O   1 
HETATM 9166 O  O   . HOH N 4 .   ? -23.188 9.513   6.407   1.00 19.20 ? 504 HOH B O   1 
HETATM 9167 O  O   . HOH N 4 .   ? -3.229  2.548   21.159  1.00 20.91 ? 505 HOH B O   1 
HETATM 9168 O  O   . HOH N 4 .   ? 1.623   -1.572  5.769   1.00 7.88  ? 506 HOH B O   1 
HETATM 9169 O  O   . HOH N 4 .   ? -17.886 -9.956  28.672  1.00 21.21 ? 507 HOH B O   1 
HETATM 9170 O  O   . HOH N 4 .   ? -22.984 -2.309  -8.631  1.00 14.26 ? 508 HOH B O   1 
HETATM 9171 O  O   . HOH N 4 .   ? -21.765 -2.806  -12.710 1.00 30.25 ? 509 HOH B O   1 
HETATM 9172 O  O   . HOH N 4 .   ? -27.680 -4.300  8.661   1.00 16.25 ? 510 HOH B O   1 
HETATM 9173 O  O   . HOH N 4 .   ? -13.519 -6.731  -11.069 1.00 14.73 ? 511 HOH B O   1 
HETATM 9174 O  O   . HOH N 4 .   ? -8.874  -8.146  -14.465 1.00 16.59 ? 512 HOH B O   1 
HETATM 9175 O  O   . HOH N 4 .   ? -14.049 -14.723 5.945   1.00 13.83 ? 513 HOH B O   1 
HETATM 9176 O  O   . HOH N 4 .   ? 6.623   3.293   9.116   1.00 6.31  ? 514 HOH B O   1 
HETATM 9177 O  O   . HOH N 4 .   ? -32.963 -2.024  -8.386  1.00 28.46 ? 515 HOH B O   1 
HETATM 9178 O  O   . HOH N 4 .   ? 8.097   4.607   5.094   1.00 7.87  ? 516 HOH B O   1 
HETATM 9179 O  O   . HOH N 4 .   ? -5.644  -24.838 22.980  1.00 20.40 ? 517 HOH B O   1 
HETATM 9180 O  O   . HOH N 4 .   ? -10.960 17.426  -8.496  1.00 25.16 ? 518 HOH B O   1 
HETATM 9181 O  O   . HOH N 4 .   ? -16.960 -10.335 20.225  1.00 14.15 ? 519 HOH B O   1 
HETATM 9182 O  O   . HOH N 4 .   ? -24.108 0.827   21.068  1.00 29.66 ? 520 HOH B O   1 
HETATM 9183 O  O   . HOH N 4 .   ? -1.664  20.567  8.300   1.00 31.95 ? 521 HOH B O   1 
HETATM 9184 O  O   . HOH N 4 .   ? 3.084   -3.616  16.115  1.00 25.63 ? 522 HOH B O   1 
HETATM 9185 O  O   . HOH N 4 .   ? -5.666  1.521   -9.809  1.00 8.77  ? 523 HOH B O   1 
HETATM 9186 O  O   . HOH N 4 .   ? -1.564  16.695  10.959  1.00 11.21 ? 524 HOH B O   1 
HETATM 9187 O  O   . HOH N 4 .   ? -27.374 6.667   -11.836 1.00 20.54 ? 525 HOH B O   1 
HETATM 9188 O  O   . HOH N 4 .   ? -0.709  11.981  16.062  1.00 12.03 ? 526 HOH B O   1 
HETATM 9189 O  O   . HOH N 4 .   ? -10.330 -8.983  8.239   1.00 6.14  ? 527 HOH B O   1 
HETATM 9190 O  O   . HOH N 4 .   ? 4.925   -9.595  -12.315 1.00 26.55 ? 528 HOH B O   1 
HETATM 9191 O  O   . HOH N 4 .   ? 3.907   -2.406  -3.286  1.00 29.02 ? 529 HOH B O   1 
HETATM 9192 O  O   . HOH N 4 .   ? 3.936   -14.917 9.678   1.00 31.05 ? 530 HOH B O   1 
HETATM 9193 O  O   . HOH N 4 .   ? 8.469   -0.450  24.438  1.00 25.79 ? 531 HOH B O   1 
HETATM 9194 O  O   . HOH N 4 .   ? 4.013   11.336  -13.466 1.00 30.53 ? 532 HOH B O   1 
HETATM 9195 O  O   . HOH N 4 .   ? 5.433   19.920  10.609  1.00 20.76 ? 533 HOH B O   1 
HETATM 9196 O  O   . HOH N 4 .   ? -14.347 -10.792 23.830  1.00 18.92 ? 534 HOH B O   1 
HETATM 9197 O  O   . HOH N 4 .   ? 2.046   5.144   -5.713  1.00 19.63 ? 535 HOH B O   1 
HETATM 9198 O  O   . HOH N 4 .   ? -0.930  15.854  -8.760  1.00 32.37 ? 536 HOH B O   1 
HETATM 9199 O  O   . HOH N 4 .   ? -1.216  5.917   -4.950  1.00 14.14 ? 537 HOH B O   1 
HETATM 9200 O  O   . HOH N 4 .   ? -10.602 14.372  -13.977 1.00 13.15 ? 538 HOH B O   1 
HETATM 9201 O  O   . HOH N 4 .   ? -13.084 -17.433 7.374   1.00 37.60 ? 539 HOH B O   1 
HETATM 9202 O  O   . HOH N 4 .   ? -2.776  -0.230  25.383  1.00 25.56 ? 540 HOH B O   1 
HETATM 9203 O  O   . HOH N 4 .   ? -0.434  -13.156 22.422  1.00 28.97 ? 541 HOH B O   1 
HETATM 9204 O  O   . HOH N 4 .   ? -10.720 -10.319 29.699  1.00 21.42 ? 542 HOH B O   1 
HETATM 9205 O  O   . HOH N 4 .   ? 5.554   -8.092  -1.354  1.00 32.33 ? 543 HOH B O   1 
HETATM 9206 O  O   . HOH N 4 .   ? -24.064 8.446   23.331  1.00 36.70 ? 544 HOH B O   1 
HETATM 9207 O  O   . HOH N 4 .   ? -1.910  -11.399 -3.185  1.00 15.91 ? 545 HOH B O   1 
HETATM 9208 O  O   . HOH N 4 .   ? -29.849 -3.255  7.153   1.00 25.76 ? 546 HOH B O   1 
HETATM 9209 O  O   . HOH N 4 .   ? 6.595   4.757   13.689  1.00 10.90 ? 547 HOH B O   1 
HETATM 9210 O  O   . HOH N 4 .   ? -2.977  1.654   -14.510 1.00 28.10 ? 548 HOH B O   1 
HETATM 9211 O  O   . HOH N 4 .   ? -4.880  0.501   21.910  1.00 17.09 ? 549 HOH B O   1 
HETATM 9212 O  O   . HOH N 4 .   ? -32.635 -3.934  -1.829  1.00 28.71 ? 550 HOH B O   1 
HETATM 9213 O  O   . HOH N 4 .   ? -3.725  2.202   -11.954 1.00 11.26 ? 551 HOH B O   1 
HETATM 9214 O  O   . HOH N 4 .   ? -17.803 -3.581  26.988  1.00 27.15 ? 552 HOH B O   1 
HETATM 9215 O  O   . HOH N 4 .   ? -5.453  5.990   -0.204  1.00 16.20 ? 553 HOH B O   1 
HETATM 9216 O  O   . HOH N 4 .   ? -12.716 -0.536  22.594  1.00 22.20 ? 554 HOH B O   1 
HETATM 9217 O  O   . HOH N 4 .   ? 4.180   3.382   -5.999  1.00 16.39 ? 555 HOH B O   1 
HETATM 9218 O  O   . HOH N 4 .   ? 1.772   6.550   20.515  1.00 29.51 ? 556 HOH B O   1 
HETATM 9219 O  O   . HOH N 4 .   ? -20.894 13.587  7.953   1.00 23.80 ? 557 HOH B O   1 
HETATM 9220 O  O   . HOH N 4 .   ? -1.218  -0.634  -12.558 1.00 16.65 ? 558 HOH B O   1 
HETATM 9221 O  O   . HOH N 4 .   ? -27.204 -6.415  -4.778  1.00 26.23 ? 559 HOH B O   1 
HETATM 9222 O  O   . HOH N 4 .   ? 4.231   8.234   7.618   1.00 8.24  ? 560 HOH B O   1 
HETATM 9223 O  O   . HOH N 4 .   ? -11.804 -17.494 13.364  1.00 30.26 ? 561 HOH B O   1 
HETATM 9224 O  O   . HOH N 4 .   ? 6.057   -2.130  1.659   1.00 23.85 ? 562 HOH B O   1 
HETATM 9225 O  O   . HOH N 4 .   ? 4.915   9.143   14.386  1.00 11.66 ? 563 HOH B O   1 
HETATM 9226 O  O   . HOH N 4 .   ? -1.016  14.284  -4.679  1.00 30.41 ? 564 HOH B O   1 
HETATM 9227 O  O   . HOH N 4 .   ? -4.180  -12.676 25.885  1.00 27.13 ? 565 HOH B O   1 
HETATM 9228 O  O   . HOH N 4 .   ? 5.912   -6.040  14.701  1.00 22.81 ? 566 HOH B O   1 
HETATM 9229 O  O   . HOH N 4 .   ? -1.338  14.603  16.981  1.00 18.95 ? 567 HOH B O   1 
HETATM 9230 O  O   . HOH N 4 .   ? 2.076   6.009   -12.521 1.00 20.77 ? 568 HOH B O   1 
HETATM 9231 O  O   . HOH N 4 .   ? -6.557  -11.462 29.158  1.00 28.39 ? 569 HOH B O   1 
HETATM 9232 O  O   . HOH N 4 .   ? -31.056 1.971   2.157   1.00 20.44 ? 570 HOH B O   1 
HETATM 9233 O  O   . HOH N 4 .   ? 0.587   8.174   -4.570  1.00 16.28 ? 571 HOH B O   1 
HETATM 9234 O  O   . HOH N 4 .   ? -0.136  -13.998 8.966   1.00 26.70 ? 572 HOH B O   1 
HETATM 9235 O  O   . HOH N 4 .   ? 0.775   13.429  19.146  1.00 30.57 ? 573 HOH B O   1 
HETATM 9236 O  O   . HOH N 4 .   ? -0.616  -9.213  27.622  1.00 34.31 ? 574 HOH B O   1 
HETATM 9237 O  O   . HOH N 4 .   ? -16.532 3.009   21.892  1.00 23.42 ? 575 HOH B O   1 
HETATM 9238 O  O   . HOH N 4 .   ? -29.356 7.244   -1.779  1.00 30.53 ? 576 HOH B O   1 
HETATM 9239 O  O   . HOH N 4 .   ? 8.712   8.644   1.897   1.00 12.38 ? 577 HOH B O   1 
HETATM 9240 O  O   . HOH N 4 .   ? -8.915  -20.491 -0.798  1.00 15.37 ? 578 HOH B O   1 
HETATM 9241 O  O   . HOH N 4 .   ? -17.875 12.576  -12.720 1.00 22.64 ? 579 HOH B O   1 
HETATM 9242 O  O   . HOH N 4 .   ? -13.327 -11.935 11.685  1.00 7.98  ? 580 HOH B O   1 
HETATM 9243 O  O   . HOH N 4 .   ? -25.511 -7.384  13.097  1.00 22.72 ? 581 HOH B O   1 
HETATM 9244 O  O   . HOH N 4 .   ? -19.564 -13.637 14.503  1.00 20.06 ? 582 HOH B O   1 
HETATM 9245 O  O   . HOH N 4 .   ? -3.228  7.470   -3.743  1.00 14.47 ? 583 HOH B O   1 
HETATM 9246 O  O   . HOH N 4 .   ? -4.937  -12.635 22.503  1.00 32.53 ? 584 HOH B O   1 
HETATM 9247 O  O   . HOH N 4 .   ? 4.353   -2.076  6.349   1.00 13.79 ? 585 HOH B O   1 
HETATM 9248 O  O   . HOH N 4 .   ? 8.784   6.475   -1.976  1.00 24.77 ? 586 HOH B O   1 
HETATM 9249 O  O   . HOH N 4 .   ? -5.677  15.512  1.735   1.00 25.94 ? 587 HOH B O   1 
HETATM 9250 O  O   . HOH N 4 .   ? -22.896 6.559   -12.464 1.00 24.70 ? 588 HOH B O   1 
HETATM 9251 O  O   . HOH N 4 .   ? -7.204  7.067   18.995  1.00 21.09 ? 589 HOH B O   1 
HETATM 9252 O  O   . HOH N 4 .   ? 4.021   -9.145  3.052   1.00 23.75 ? 590 HOH B O   1 
HETATM 9253 O  O   . HOH N 4 .   ? 0.857   -8.978  25.495  1.00 32.13 ? 591 HOH B O   1 
HETATM 9254 O  O   . HOH N 4 .   ? -3.179  -12.702 -1.017  1.00 17.99 ? 592 HOH B O   1 
HETATM 9255 O  O   . HOH N 4 .   ? -15.863 -8.757  -13.155 1.00 33.68 ? 593 HOH B O   1 
HETATM 9256 O  O   . HOH N 4 .   ? -23.424 11.369  -1.303  1.00 19.19 ? 594 HOH B O   1 
HETATM 9257 O  O   . HOH N 4 .   ? -3.704  17.141  -0.744  1.00 32.15 ? 595 HOH B O   1 
HETATM 9258 O  O   . HOH N 4 .   ? -20.180 17.297  21.157  1.00 33.17 ? 596 HOH B O   1 
HETATM 9259 O  O   . HOH N 4 .   ? -21.708 10.171  3.338   1.00 22.19 ? 597 HOH B O   1 
HETATM 9260 O  O   . HOH N 4 .   ? -5.804  -15.276 13.350  1.00 25.95 ? 598 HOH B O   1 
HETATM 9261 O  O   . HOH N 4 .   ? -14.595 -14.146 0.692   1.00 15.97 ? 599 HOH B O   1 
HETATM 9262 O  O   . HOH N 4 .   ? 6.874   -1.307  17.376  1.00 17.99 ? 600 HOH B O   1 
HETATM 9263 O  O   . HOH N 4 .   ? -24.292 8.914   -1.699  1.00 16.01 ? 601 HOH B O   1 
HETATM 9264 O  O   . HOH N 4 .   ? 4.139   10.011  -6.894  1.00 23.07 ? 602 HOH B O   1 
HETATM 9265 O  O   . HOH N 4 .   ? -34.733 -2.710  -1.959  1.00 27.92 ? 603 HOH B O   1 
HETATM 9266 O  O   . HOH N 4 .   ? -26.552 10.334  4.927   1.00 33.88 ? 604 HOH B O   1 
HETATM 9267 O  O   . HOH N 4 .   ? -9.518  -1.999  -14.426 1.00 26.51 ? 605 HOH B O   1 
HETATM 9268 O  O   . HOH N 4 .   ? -16.642 5.804   -18.214 1.00 32.86 ? 606 HOH B O   1 
HETATM 9269 O  O   . HOH N 4 .   ? -26.254 -9.622  6.214   1.00 24.87 ? 607 HOH B O   1 
HETATM 9270 O  O   . HOH N 4 .   ? 3.454   21.370  9.415   1.00 23.78 ? 608 HOH B O   1 
HETATM 9271 O  O   . HOH N 4 .   ? 2.768   6.718   16.729  1.00 23.88 ? 609 HOH B O   1 
HETATM 9272 O  O   . HOH N 4 .   ? -12.022 -2.581  -10.689 1.00 23.98 ? 610 HOH B O   1 
HETATM 9273 O  O   . HOH N 4 .   ? -17.326 9.935   -14.119 1.00 34.21 ? 611 HOH B O   1 
HETATM 9274 O  O   . HOH N 4 .   ? -5.811  18.063  11.518  1.00 34.50 ? 612 HOH B O   1 
HETATM 9275 O  O   . HOH N 4 .   ? 7.742   -7.098  16.742  1.00 29.50 ? 613 HOH B O   1 
HETATM 9276 O  O   . HOH N 4 .   ? -2.034  11.849  -5.189  1.00 20.90 ? 614 HOH B O   1 
HETATM 9277 O  O   . HOH N 4 .   ? -29.775 7.858   6.014   1.00 30.71 ? 615 HOH B O   1 
HETATM 9278 O  O   . HOH N 4 .   ? -14.819 -14.671 -2.524  1.00 12.36 ? 616 HOH B O   1 
HETATM 9279 O  O   . HOH N 4 .   ? -30.795 7.232   -4.434  1.00 21.78 ? 617 HOH B O   1 
HETATM 9280 O  O   . HOH N 4 .   ? -11.599 -19.698 25.158  1.00 31.62 ? 618 HOH B O   1 
HETATM 9281 O  O   . HOH N 4 .   ? -9.490  16.829  -16.231 1.00 18.82 ? 619 HOH B O   1 
HETATM 9282 O  O   . HOH N 4 .   ? 3.692   -16.156 18.328  1.00 33.23 ? 620 HOH B O   1 
HETATM 9283 O  O   . HOH N 4 .   ? -8.437  17.544  10.772  1.00 29.56 ? 621 HOH B O   1 
HETATM 9284 O  O   . HOH N 4 .   ? -0.831  20.243  -0.617  1.00 38.19 ? 622 HOH B O   1 
HETATM 9285 O  O   . HOH N 4 .   ? -13.977 10.996  3.417   1.00 41.44 ? 623 HOH B O   1 
HETATM 9286 O  O   . HOH N 4 .   ? 3.452   -11.093 3.385   1.00 29.52 ? 624 HOH B O   1 
HETATM 9287 O  O   . HOH N 4 .   ? 5.006   -3.201  17.460  1.00 29.40 ? 625 HOH B O   1 
HETATM 9288 O  O   . HOH N 4 .   ? -0.849  -12.554 15.571  1.00 36.10 ? 626 HOH B O   1 
HETATM 9289 O  O   . HOH N 4 .   ? 7.820   -3.280  3.514   1.00 17.00 ? 627 HOH B O   1 
HETATM 9290 O  O   . HOH N 4 .   ? -2.374  -12.572 24.609  1.00 30.44 ? 628 HOH B O   1 
HETATM 9291 O  O   . HOH N 4 .   ? -16.099 -5.651  -12.842 1.00 33.20 ? 629 HOH B O   1 
HETATM 9292 O  O   . HOH N 4 .   ? 4.195   -13.264 22.489  1.00 26.45 ? 630 HOH B O   1 
HETATM 9293 O  O   . HOH N 4 .   ? -20.319 -13.438 11.731  1.00 28.08 ? 631 HOH B O   1 
HETATM 9294 O  O   . HOH N 4 .   ? -20.533 12.075  -13.111 1.00 35.45 ? 632 HOH B O   1 
HETATM 9295 O  O   . HOH N 4 .   ? 4.068   -4.396  1.083   1.00 28.77 ? 633 HOH B O   1 
HETATM 9296 O  O   . HOH N 4 .   ? -13.367 13.153  3.110   1.00 34.31 ? 634 HOH B O   1 
HETATM 9297 O  O   . HOH N 4 .   ? -1.822  9.767   -3.300  1.00 22.81 ? 635 HOH B O   1 
HETATM 9298 O  O   . HOH N 4 .   ? -5.565  14.755  -4.698  1.00 34.02 ? 636 HOH B O   1 
HETATM 9299 O  O   . HOH N 4 .   ? 1.450   22.589  9.430   1.00 38.37 ? 637 HOH B O   1 
HETATM 9300 O  O   . HOH N 4 .   ? -24.788 -1.206  -11.572 1.00 25.29 ? 638 HOH B O   1 
HETATM 9301 O  O   . HOH N 4 .   ? -1.214  -12.975 4.513   1.00 36.70 ? 639 HOH B O   1 
HETATM 9302 O  O   . HOH N 4 .   ? -21.465 -6.374  -9.795  1.00 23.74 ? 640 HOH B O   1 
HETATM 9303 O  O   . HOH N 4 .   ? -31.965 -2.076  6.234   1.00 40.39 ? 641 HOH B O   1 
HETATM 9304 O  O   . HOH N 4 .   ? -12.932 6.565   -18.009 1.00 34.63 ? 642 HOH B O   1 
HETATM 9305 O  O   . HOH N 4 .   ? -24.761 8.280   1.122   1.00 22.80 ? 643 HOH B O   1 
HETATM 9306 O  O   . HOH N 4 .   ? -17.696 -3.828  22.099  1.00 31.92 ? 644 HOH B O   1 
HETATM 9307 O  O   . HOH N 4 .   ? 3.432   13.967  -7.274  1.00 31.52 ? 645 HOH B O   1 
HETATM 9308 O  O   . HOH N 4 .   ? -17.678 -14.167 -2.207  1.00 26.97 ? 646 HOH B O   1 
HETATM 9309 O  O   . HOH N 4 .   ? -16.165 8.058   -16.911 1.00 31.95 ? 647 HOH B O   1 
HETATM 9310 O  O   . HOH N 4 .   ? -16.870 -16.874 3.461   1.00 38.43 ? 648 HOH B O   1 
HETATM 9311 O  O   . HOH N 4 .   ? -9.393  20.522  -12.210 1.00 42.56 ? 649 HOH B O   1 
HETATM 9312 O  O   . HOH N 4 .   ? -9.624  20.365  -8.445  1.00 35.34 ? 650 HOH B O   1 
HETATM 9313 O  O   . HOH N 4 .   ? -30.217 4.596   2.417   1.00 26.94 ? 651 HOH B O   1 
HETATM 9314 O  O   . HOH N 4 .   ? -33.296 6.843   -5.364  1.00 32.27 ? 652 HOH B O   1 
HETATM 9315 O  O   . HOH N 4 .   ? -20.064 -9.775  -12.119 1.00 30.09 ? 653 HOH B O   1 
HETATM 9316 O  O   . HOH N 4 .   ? -12.722 -9.038  -12.488 1.00 22.66 ? 654 HOH B O   1 
HETATM 9317 O  O   . HOH N 4 .   ? -11.035 15.845  -6.109  1.00 30.40 ? 655 HOH B O   1 
HETATM 9318 O  O   . HOH N 4 .   ? 12.772  11.318  -3.657  1.00 27.55 ? 656 HOH B O   1 
HETATM 9319 O  O   . HOH N 4 .   ? -3.643  15.765  -8.845  1.00 30.53 ? 657 HOH B O   1 
HETATM 9320 O  O   . HOH N 4 .   ? -0.226  -13.333 -4.324  1.00 27.08 ? 658 HOH B O   1 
HETATM 9321 O  O   . HOH N 4 .   ? 6.370   -5.598  11.283  1.00 30.97 ? 659 HOH B O   1 
HETATM 9322 O  O   . HOH N 4 .   ? -23.456 11.026  1.877   1.00 38.19 ? 660 HOH B O   1 
HETATM 9323 O  O   . HOH N 4 .   ? 3.906   14.909  -10.501 1.00 30.27 ? 661 HOH B O   1 
HETATM 9324 O  O   . HOH N 4 .   ? -11.348 -8.341  -14.874 1.00 26.62 ? 662 HOH B O   1 
HETATM 9325 O  O   . HOH N 4 .   ? -21.498 9.953   -14.675 1.00 40.03 ? 663 HOH B O   1 
HETATM 9326 O  O   . HOH N 4 .   ? 1.550   -0.657  -12.055 1.00 30.90 ? 664 HOH B O   1 
HETATM 9327 O  O   . HOH N 4 .   ? -23.286 -4.574  -9.996  1.00 26.20 ? 665 HOH B O   1 
HETATM 9328 O  O   . HOH N 4 .   ? -29.705 7.100   1.142   1.00 28.84 ? 666 HOH B O   1 
HETATM 9329 O  O   . HOH N 4 .   ? 5.909   2.251   -3.611  1.00 25.56 ? 667 HOH B O   1 
HETATM 9330 O  O   . HOH N 4 .   ? 2.018   -15.768 16.661  1.00 23.44 ? 668 HOH B O   1 
HETATM 9331 O  O   . HOH N 4 .   ? 7.799   6.031   0.751   1.00 20.47 ? 669 HOH B O   1 
HETATM 9332 O  O   . HOH N 4 .   ? -29.316 -7.645  6.493   1.00 28.14 ? 670 HOH B O   1 
HETATM 9333 O  O   . HOH N 4 .   ? -16.723 -14.078 27.834  1.00 18.57 ? 671 HOH B O   1 
HETATM 9334 O  O   . HOH N 4 .   ? -21.441 -11.966 15.817  1.00 23.18 ? 672 HOH B O   1 
HETATM 9335 O  O   . HOH N 4 .   ? -8.141  -5.850  -15.778 1.00 24.74 ? 673 HOH B O   1 
HETATM 9336 O  O   . HOH N 4 .   ? -15.071 1.240   22.996  1.00 35.76 ? 674 HOH B O   1 
HETATM 9337 O  O   . HOH N 4 .   ? -13.912 -4.976  -13.128 1.00 26.94 ? 675 HOH B O   1 
HETATM 9338 O  O   . HOH N 4 .   ? 7.544   -9.429  15.671  1.00 21.75 ? 676 HOH B O   1 
HETATM 9339 O  O   . HOH N 4 .   ? 2.453   -11.267 -12.032 1.00 32.28 ? 677 HOH B O   1 
HETATM 9340 O  O   . HOH N 4 .   ? -15.699 -14.542 3.649   1.00 35.44 ? 678 HOH B O   1 
HETATM 9341 O  O   . HOH N 4 .   ? 5.208   -13.019 15.849  1.00 24.66 ? 679 HOH B O   1 
HETATM 9342 O  O   . HOH N 4 .   ? -4.525  -13.823 9.700   1.00 29.87 ? 680 HOH B O   1 
HETATM 9343 O  O   . HOH N 4 .   ? -29.245 -6.095  -2.648  1.00 34.05 ? 681 HOH B O   1 
HETATM 9344 O  O   . HOH N 4 .   ? -10.769 16.770  -18.912 1.00 29.46 ? 682 HOH B O   1 
HETATM 9345 O  O   . HOH N 4 .   ? -19.287 -16.652 -3.979  1.00 28.80 ? 683 HOH B O   1 
HETATM 9346 O  O   . HOH N 4 .   ? -0.861  21.958  10.811  1.00 40.90 ? 684 HOH B O   1 
HETATM 9347 O  O   . HOH N 4 .   ? -10.338 -0.435  -15.986 1.00 35.60 ? 685 HOH B O   1 
HETATM 9348 O  O   . HOH N 4 .   ? -17.551 -12.769 21.251  1.00 24.35 ? 686 HOH B O   1 
HETATM 9349 O  O   . HOH N 4 .   ? -18.504 -11.899 23.875  1.00 33.50 ? 687 HOH B O   1 
HETATM 9350 O  O   . HOH N 4 .   ? 4.930   -7.267  1.166   1.00 23.80 ? 688 HOH B O   1 
HETATM 9351 O  O   . HOH N 4 .   ? 1.388   -15.272 22.889  1.00 32.26 ? 689 HOH B O   1 
HETATM 9352 O  O   . HOH N 4 .   ? -26.153 10.185  23.939  1.00 40.78 ? 690 HOH B O   1 
HETATM 9353 O  O   . HOH N 4 .   ? -3.653  15.325  18.340  1.00 31.57 ? 691 HOH B O   1 
HETATM 9354 O  O   . HOH N 4 .   ? -20.859 -10.850 -9.833  1.00 24.12 ? 692 HOH B O   1 
HETATM 9355 O  O   . HOH N 4 .   ? -13.332 -11.861 -13.104 1.00 23.24 ? 693 HOH B O   1 
HETATM 9356 O  O   . HOH N 4 .   ? -27.276 8.932   1.395   1.00 34.85 ? 694 HOH B O   1 
HETATM 9357 O  O   . HOH N 4 .   ? -7.701  -10.097 -16.001 1.00 19.70 ? 695 HOH B O   1 
HETATM 9358 O  O   . HOH N 4 .   ? -13.443 -21.620 22.578  1.00 33.57 ? 696 HOH B O   1 
HETATM 9359 O  O   . HOH N 4 .   ? -2.973  18.980  10.279  1.00 25.99 ? 697 HOH B O   1 
HETATM 9360 O  O   . HOH N 4 .   ? -13.350 -21.536 3.924   1.00 25.72 ? 698 HOH B O   1 
HETATM 9361 O  O   . HOH N 4 .   ? -13.083 -14.135 30.895  1.00 18.20 ? 699 HOH B O   1 
HETATM 9362 O  O   . HOH N 4 .   ? -10.613 -13.114 30.576  1.00 20.63 ? 700 HOH B O   1 
HETATM 9363 O  O   . HOH N 4 .   ? -19.196 -16.139 15.407  1.00 28.10 ? 701 HOH B O   1 
HETATM 9364 O  O   . HOH N 4 .   ? 12.910  11.458  -6.473  1.00 30.28 ? 702 HOH B O   1 
HETATM 9365 O  O   . HOH N 4 .   ? 11.195  9.469   -7.202  1.00 49.79 ? 703 HOH B O   1 
HETATM 9366 O  O   . HOH N 4 .   ? -4.874  19.026  7.647   1.00 34.62 ? 704 HOH B O   1 
HETATM 9367 O  O   . HOH N 4 .   ? -25.690 -6.074  -8.982  1.00 32.91 ? 705 HOH B O   1 
HETATM 9368 O  O   . HOH N 4 .   ? -12.126 -10.996 -15.989 1.00 33.40 ? 706 HOH B O   1 
HETATM 9369 O  O   . HOH N 4 .   ? 11.922  6.777   -8.341  1.00 37.88 ? 707 HOH B O   1 
HETATM 9370 O  O   . HOH O 4 .   ? 27.473  25.457  -32.338 1.00 15.30 ? 401 HOH C O   1 
HETATM 9371 O  O   . HOH O 4 .   ? 21.749  17.888  -27.633 1.00 31.16 ? 402 HOH C O   1 
HETATM 9372 O  O   . HOH O 4 .   ? 19.765  1.630   -51.657 1.00 19.60 ? 403 HOH C O   1 
HETATM 9373 O  O   . HOH O 4 .   ? 28.600  7.141   -19.108 1.00 37.02 ? 404 HOH C O   1 
HETATM 9374 O  O   . HOH O 4 .   ? 57.251  -8.580  -23.429 1.00 33.55 ? 405 HOH C O   1 
HETATM 9375 O  O   . HOH O 4 .   ? 40.785  -5.358  -52.806 1.00 31.34 ? 406 HOH C O   1 
HETATM 9376 O  O   . HOH O 4 .   ? 53.573  -3.444  -46.330 1.00 35.19 ? 407 HOH C O   1 
HETATM 9377 O  O   . HOH O 4 .   ? 36.418  -9.345  -53.837 1.00 28.45 ? 408 HOH C O   1 
HETATM 9378 O  O   . HOH O 4 .   ? 32.814  4.963   -30.516 1.00 11.58 ? 409 HOH C O   1 
HETATM 9379 O  O   . HOH O 4 .   ? 56.523  8.006   -37.442 1.00 26.62 ? 410 HOH C O   1 
HETATM 9380 O  O   . HOH O 4 .   ? 33.538  22.490  -35.281 1.00 24.57 ? 411 HOH C O   1 
HETATM 9381 O  O   . HOH O 4 .   ? 52.875  0.802   -13.364 1.00 22.25 ? 412 HOH C O   1 
HETATM 9382 O  O   . HOH O 4 .   ? 35.611  -19.945 -43.969 1.00 32.69 ? 413 HOH C O   1 
HETATM 9383 O  O   . HOH O 4 .   ? 20.745  -1.978  -51.010 1.00 34.83 ? 414 HOH C O   1 
HETATM 9384 O  O   . HOH O 4 .   ? 51.517  8.159   -31.314 1.00 23.05 ? 415 HOH C O   1 
HETATM 9385 O  O   . HOH O 4 .   ? 35.938  -13.542 -54.569 1.00 18.26 ? 416 HOH C O   1 
HETATM 9386 O  O   . HOH O 4 .   ? 59.549  4.546   -34.789 1.00 41.94 ? 417 HOH C O   1 
HETATM 9387 O  O   . HOH O 4 .   ? 28.634  18.416  -31.770 1.00 11.32 ? 418 HOH C O   1 
HETATM 9388 O  O   . HOH O 4 .   ? 25.028  -13.043 -41.642 1.00 22.33 ? 419 HOH C O   1 
HETATM 9389 O  O   . HOH O 4 .   ? 22.541  -8.778  -39.875 1.00 22.56 ? 420 HOH C O   1 
HETATM 9390 O  O   . HOH O 4 .   ? 20.645  17.896  -30.022 1.00 23.95 ? 421 HOH C O   1 
HETATM 9391 O  O   . HOH O 4 .   ? 38.931  -2.827  -11.768 1.00 28.57 ? 422 HOH C O   1 
HETATM 9392 O  O   . HOH O 4 .   ? 47.080  -14.703 -32.403 1.00 30.64 ? 423 HOH C O   1 
HETATM 9393 O  O   . HOH O 4 .   ? 47.744  -1.723  -10.350 1.00 33.31 ? 424 HOH C O   1 
HETATM 9394 O  O   . HOH O 4 .   ? 34.043  -16.704 -17.163 1.00 36.88 ? 425 HOH C O   1 
HETATM 9395 O  O   . HOH O 4 .   ? 52.956  4.869   -49.011 1.00 29.23 ? 426 HOH C O   1 
HETATM 9396 O  O   . HOH O 4 .   ? 55.872  5.421   -22.336 1.00 29.09 ? 427 HOH C O   1 
HETATM 9397 O  O   . HOH O 4 .   ? 33.469  -1.343  -49.047 1.00 17.96 ? 428 HOH C O   1 
HETATM 9398 O  O   . HOH O 4 .   ? 26.133  5.490   -24.151 1.00 24.13 ? 429 HOH C O   1 
HETATM 9399 O  O   . HOH O 4 .   ? 62.250  -0.990  -32.671 1.00 25.23 ? 430 HOH C O   1 
HETATM 9400 O  O   . HOH O 4 .   ? 33.572  11.701  -10.784 1.00 24.79 ? 431 HOH C O   1 
HETATM 9401 O  O   . HOH O 4 .   ? 29.895  -5.001  -22.151 1.00 13.54 ? 432 HOH C O   1 
HETATM 9402 O  O   . HOH O 4 .   ? 25.537  -1.585  -40.740 1.00 9.50  ? 433 HOH C O   1 
HETATM 9403 O  O   . HOH O 4 .   ? 25.563  8.228   -28.083 1.00 13.39 ? 434 HOH C O   1 
HETATM 9404 O  O   . HOH O 4 .   ? 42.154  6.575   -9.782  1.00 28.22 ? 435 HOH C O   1 
HETATM 9405 O  O   . HOH O 4 .   ? 40.310  -16.599 -30.662 1.00 22.09 ? 436 HOH C O   1 
HETATM 9406 O  O   . HOH O 4 .   ? 26.277  5.546   -43.467 1.00 16.79 ? 437 HOH C O   1 
HETATM 9407 O  O   . HOH O 4 .   ? 25.262  6.678   -34.689 1.00 8.94  ? 438 HOH C O   1 
HETATM 9408 O  O   . HOH O 4 .   ? 44.815  -14.751 -50.392 1.00 30.68 ? 439 HOH C O   1 
HETATM 9409 O  O   . HOH O 4 .   ? 28.869  -8.205  -17.369 1.00 21.06 ? 440 HOH C O   1 
HETATM 9410 O  O   . HOH O 4 .   ? 21.060  -1.369  -22.285 1.00 37.82 ? 441 HOH C O   1 
HETATM 9411 O  O   . HOH O 4 .   ? 41.871  -8.301  -55.067 1.00 18.49 ? 442 HOH C O   1 
HETATM 9412 O  O   . HOH O 4 .   ? 56.575  3.634   -13.001 1.00 17.99 ? 443 HOH C O   1 
HETATM 9413 O  O   . HOH O 4 .   ? 43.388  -2.370  -40.408 1.00 8.94  ? 444 HOH C O   1 
HETATM 9414 O  O   . HOH O 4 .   ? 28.132  16.149  -29.344 1.00 23.73 ? 445 HOH C O   1 
HETATM 9415 O  O   . HOH O 4 .   ? 46.617  7.973   -11.558 1.00 21.28 ? 446 HOH C O   1 
HETATM 9416 O  O   . HOH O 4 .   ? 56.909  4.385   -41.964 1.00 15.41 ? 447 HOH C O   1 
HETATM 9417 O  O   . HOH O 4 .   ? 22.539  -6.192  -31.518 1.00 20.06 ? 448 HOH C O   1 
HETATM 9418 O  O   . HOH O 4 .   ? 53.918  -13.716 -25.887 1.00 32.47 ? 449 HOH C O   1 
HETATM 9419 O  O   . HOH O 4 .   ? 24.243  13.186  -42.364 1.00 13.22 ? 450 HOH C O   1 
HETATM 9420 O  O   . HOH O 4 .   ? 28.821  3.337   -43.540 1.00 13.09 ? 451 HOH C O   1 
HETATM 9421 O  O   . HOH O 4 .   ? 53.137  6.000   -31.457 1.00 15.26 ? 452 HOH C O   1 
HETATM 9422 O  O   . HOH O 4 .   ? 26.140  -3.377  -42.698 1.00 15.94 ? 453 HOH C O   1 
HETATM 9423 O  O   . HOH O 4 .   ? 34.396  15.984  -38.354 1.00 9.52  ? 454 HOH C O   1 
HETATM 9424 O  O   . HOH O 4 .   ? 23.764  -4.470  -36.075 1.00 13.99 ? 455 HOH C O   1 
HETATM 9425 O  O   . HOH O 4 .   ? 41.534  7.418   -46.800 1.00 20.83 ? 456 HOH C O   1 
HETATM 9426 O  O   . HOH O 4 .   ? 41.079  13.815  -36.858 1.00 19.47 ? 457 HOH C O   1 
HETATM 9427 O  O   . HOH O 4 .   ? 24.129  9.104   -34.983 1.00 12.91 ? 458 HOH C O   1 
HETATM 9428 O  O   . HOH O 4 .   ? 27.602  16.306  -41.145 1.00 9.97  ? 459 HOH C O   1 
HETATM 9429 O  O   . HOH O 4 .   ? 30.267  6.427   -21.814 1.00 28.26 ? 460 HOH C O   1 
HETATM 9430 O  O   . HOH O 4 .   ? 47.031  2.170   -47.368 1.00 23.48 ? 461 HOH C O   1 
HETATM 9431 O  O   . HOH O 4 .   ? 26.289  7.050   -41.214 1.00 7.80  ? 462 HOH C O   1 
HETATM 9432 O  O   . HOH O 4 .   ? 51.698  -2.527  -43.741 1.00 19.18 ? 463 HOH C O   1 
HETATM 9433 O  O   . HOH O 4 .   ? 19.694  -7.612  -17.667 1.00 26.54 ? 464 HOH C O   1 
HETATM 9434 O  O   . HOH O 4 .   ? 24.317  -2.990  -27.364 1.00 32.69 ? 465 HOH C O   1 
HETATM 9435 O  O   . HOH O 4 .   ? 35.784  19.595  -35.805 1.00 35.34 ? 466 HOH C O   1 
HETATM 9436 O  O   . HOH O 4 .   ? 60.166  -2.149  -35.372 1.00 30.60 ? 467 HOH C O   1 
HETATM 9437 O  O   . HOH O 4 .   ? 47.420  9.128   -27.183 1.00 24.76 ? 468 HOH C O   1 
HETATM 9438 O  O   . HOH O 4 .   ? 52.095  -5.499  -18.277 1.00 28.70 ? 469 HOH C O   1 
HETATM 9439 O  O   . HOH O 4 .   ? 55.168  0.774   -14.994 1.00 26.97 ? 470 HOH C O   1 
HETATM 9440 O  O   . HOH O 4 .   ? 44.104  -5.549  -50.340 1.00 24.80 ? 471 HOH C O   1 
HETATM 9441 O  O   . HOH O 4 .   ? 45.487  -6.965  -45.598 1.00 17.16 ? 472 HOH C O   1 
HETATM 9442 O  O   . HOH O 4 .   ? 43.826  4.190   -44.375 1.00 15.18 ? 473 HOH C O   1 
HETATM 9443 O  O   . HOH O 4 .   ? 25.476  -7.287  -51.264 1.00 39.99 ? 474 HOH C O   1 
HETATM 9444 O  O   . HOH O 4 .   ? 50.181  -9.268  -46.269 1.00 25.60 ? 475 HOH C O   1 
HETATM 9445 O  O   . HOH O 4 .   ? 37.549  8.981   -47.414 1.00 22.64 ? 476 HOH C O   1 
HETATM 9446 O  O   . HOH O 4 .   ? 27.470  -10.401 -26.834 1.00 21.69 ? 477 HOH C O   1 
HETATM 9447 O  O   . HOH O 4 .   ? 40.122  13.615  -12.320 1.00 30.84 ? 478 HOH C O   1 
HETATM 9448 O  O   . HOH O 4 .   ? 32.890  -13.404 -37.145 1.00 18.05 ? 479 HOH C O   1 
HETATM 9449 O  O   . HOH O 4 .   ? 27.299  -0.713  -32.327 1.00 8.49  ? 480 HOH C O   1 
HETATM 9450 O  O   . HOH O 4 .   ? 22.406  6.895   -32.259 1.00 8.55  ? 481 HOH C O   1 
HETATM 9451 O  O   . HOH O 4 .   ? 55.848  -8.469  -32.922 1.00 20.62 ? 482 HOH C O   1 
HETATM 9452 O  O   . HOH O 4 .   ? 60.492  -7.475  -25.806 1.00 40.66 ? 483 HOH C O   1 
HETATM 9453 O  O   . HOH O 4 .   ? 53.799  -10.421 -22.683 1.00 26.81 ? 484 HOH C O   1 
HETATM 9454 O  O   . HOH O 4 .   ? 47.984  -8.814  -51.536 1.00 25.73 ? 485 HOH C O   1 
HETATM 9455 O  O   . HOH O 4 .   ? 33.960  1.392   -16.608 1.00 14.88 ? 486 HOH C O   1 
HETATM 9456 O  O   . HOH O 4 .   ? 40.001  -8.337  -14.327 1.00 32.86 ? 487 HOH C O   1 
HETATM 9457 O  O   . HOH O 4 .   ? 22.517  -5.096  -41.146 1.00 24.38 ? 488 HOH C O   1 
HETATM 9458 O  O   . HOH O 4 .   ? 54.195  -6.969  -18.208 1.00 27.09 ? 489 HOH C O   1 
HETATM 9459 O  O   . HOH O 4 .   ? 37.843  -10.528 -33.428 1.00 11.10 ? 490 HOH C O   1 
HETATM 9460 O  O   . HOH O 4 .   ? 20.337  -10.093 -29.866 1.00 19.60 ? 491 HOH C O   1 
HETATM 9461 O  O   . HOH O 4 .   ? 58.586  -2.291  -30.221 1.00 33.08 ? 492 HOH C O   1 
HETATM 9462 O  O   . HOH O 4 .   ? 38.286  -14.263 -13.574 1.00 31.60 ? 493 HOH C O   1 
HETATM 9463 O  O   . HOH O 4 .   ? 54.643  -10.201 -31.033 1.00 23.46 ? 494 HOH C O   1 
HETATM 9464 O  O   . HOH O 4 .   ? 48.139  -13.107 -39.451 1.00 26.85 ? 495 HOH C O   1 
HETATM 9465 O  O   . HOH O 4 .   ? 35.580  17.196  -41.576 1.00 22.71 ? 496 HOH C O   1 
HETATM 9466 O  O   . HOH O 4 .   ? 40.455  -16.078 -25.662 1.00 27.11 ? 497 HOH C O   1 
HETATM 9467 O  O   . HOH O 4 .   ? 51.915  12.824  -47.416 1.00 25.69 ? 498 HOH C O   1 
HETATM 9468 O  O   . HOH O 4 .   ? 43.098  -19.795 -41.056 1.00 31.58 ? 499 HOH C O   1 
HETATM 9469 O  O   . HOH O 4 .   ? 23.602  4.827   -36.080 1.00 6.76  ? 500 HOH C O   1 
HETATM 9470 O  O   . HOH O 4 .   ? 59.994  -2.891  -25.865 1.00 33.30 ? 501 HOH C O   1 
HETATM 9471 O  O   . HOH O 4 .   ? 31.815  2.105   -14.632 1.00 19.56 ? 502 HOH C O   1 
HETATM 9472 O  O   . HOH O 4 .   ? 26.969  9.464   -34.747 1.00 7.82  ? 503 HOH C O   1 
HETATM 9473 O  O   . HOH O 4 .   ? 25.876  -3.018  -48.295 1.00 21.89 ? 504 HOH C O   1 
HETATM 9474 O  O   . HOH O 4 .   ? 29.372  6.144   -47.346 1.00 14.18 ? 505 HOH C O   1 
HETATM 9475 O  O   . HOH O 4 .   ? 56.457  9.080   -40.000 1.00 29.57 ? 506 HOH C O   1 
HETATM 9476 O  O   . HOH O 4 .   ? 45.370  16.591  -38.500 1.00 23.21 ? 507 HOH C O   1 
HETATM 9477 O  O   . HOH O 4 .   ? 47.116  -12.993 -53.187 1.00 19.09 ? 508 HOH C O   1 
HETATM 9478 O  O   . HOH O 4 .   ? 34.082  13.559  -44.179 1.00 14.94 ? 509 HOH C O   1 
HETATM 9479 O  O   . HOH O 4 .   ? 24.604  -3.640  -44.797 1.00 24.70 ? 510 HOH C O   1 
HETATM 9480 O  O   . HOH O 4 .   ? 46.458  -11.375 -40.556 1.00 20.75 ? 511 HOH C O   1 
HETATM 9481 O  O   . HOH O 4 .   ? 44.940  -13.844 -44.805 1.00 18.54 ? 512 HOH C O   1 
HETATM 9482 O  O   . HOH O 4 .   ? 26.059  13.075  -35.448 1.00 8.10  ? 513 HOH C O   1 
HETATM 9483 O  O   . HOH O 4 .   ? 26.587  -8.680  -16.151 1.00 25.57 ? 514 HOH C O   1 
HETATM 9484 O  O   . HOH O 4 .   ? 43.292  -1.642  -10.800 1.00 32.53 ? 515 HOH C O   1 
HETATM 9485 O  O   . HOH O 4 .   ? 48.201  -11.096 -16.183 1.00 27.46 ? 516 HOH C O   1 
HETATM 9486 O  O   . HOH O 4 .   ? 26.708  -13.413 -34.656 1.00 18.60 ? 517 HOH C O   1 
HETATM 9487 O  O   . HOH O 4 .   ? 30.321  -10.697 -16.802 1.00 37.47 ? 518 HOH C O   1 
HETATM 9488 O  O   . HOH O 4 .   ? 58.135  -7.516  -31.169 1.00 22.41 ? 519 HOH C O   1 
HETATM 9489 O  O   . HOH O 4 .   ? 47.243  8.608   -29.977 1.00 25.78 ? 520 HOH C O   1 
HETATM 9490 O  O   . HOH O 4 .   ? 51.491  7.145   -28.534 1.00 21.55 ? 521 HOH C O   1 
HETATM 9491 O  O   . HOH O 4 .   ? 46.830  -0.722  -47.382 1.00 28.22 ? 522 HOH C O   1 
HETATM 9492 O  O   . HOH O 4 .   ? 47.330  7.196   -22.918 1.00 22.32 ? 523 HOH C O   1 
HETATM 9493 O  O   . HOH O 4 .   ? 43.683  -13.178 -26.139 1.00 22.21 ? 524 HOH C O   1 
HETATM 9494 O  O   . HOH O 4 .   ? 26.531  6.770   -14.131 1.00 32.88 ? 525 HOH C O   1 
HETATM 9495 O  O   . HOH O 4 .   ? 24.927  -2.027  -23.782 1.00 24.21 ? 526 HOH C O   1 
HETATM 9496 O  O   . HOH O 4 .   ? 29.570  9.123   -22.381 1.00 30.85 ? 527 HOH C O   1 
HETATM 9497 O  O   . HOH O 4 .   ? 22.742  0.070   -28.161 1.00 26.81 ? 528 HOH C O   1 
HETATM 9498 O  O   . HOH O 4 .   ? 32.716  11.362  -43.268 1.00 7.69  ? 529 HOH C O   1 
HETATM 9499 O  O   . HOH O 4 .   ? 34.787  -8.489  -11.314 1.00 27.84 ? 530 HOH C O   1 
HETATM 9500 O  O   . HOH O 4 .   ? 50.437  -5.257  -16.199 1.00 34.24 ? 531 HOH C O   1 
HETATM 9501 O  O   . HOH O 4 .   ? 36.068  -0.950  -48.547 1.00 16.24 ? 532 HOH C O   1 
HETATM 9502 O  O   . HOH O 4 .   ? 53.107  8.398   -23.910 1.00 26.57 ? 533 HOH C O   1 
HETATM 9503 O  O   . HOH O 4 .   ? 26.567  11.476  -45.547 1.00 27.04 ? 534 HOH C O   1 
HETATM 9504 O  O   . HOH O 4 .   ? 32.139  2.576   -43.650 1.00 11.73 ? 535 HOH C O   1 
HETATM 9505 O  O   . HOH O 4 .   ? 57.673  3.555   -38.158 1.00 32.30 ? 536 HOH C O   1 
HETATM 9506 O  O   . HOH O 4 .   ? 30.398  15.563  -43.819 1.00 22.85 ? 537 HOH C O   1 
HETATM 9507 O  O   . HOH O 4 .   ? 28.172  -10.670 -22.603 1.00 19.83 ? 538 HOH C O   1 
HETATM 9508 O  O   . HOH O 4 .   ? 42.407  -3.812  -48.403 1.00 20.15 ? 539 HOH C O   1 
HETATM 9509 O  O   . HOH O 4 .   ? 32.679  7.359   -22.409 1.00 22.15 ? 540 HOH C O   1 
HETATM 9510 O  O   . HOH O 4 .   ? 24.470  -0.645  -32.942 1.00 16.71 ? 541 HOH C O   1 
HETATM 9511 O  O   . HOH O 4 .   ? 52.003  9.868   -33.393 1.00 19.58 ? 542 HOH C O   1 
HETATM 9512 O  O   . HOH O 4 .   ? 22.702  10.990  -29.356 1.00 14.76 ? 543 HOH C O   1 
HETATM 9513 O  O   . HOH O 4 .   ? 46.475  -16.974 -38.709 1.00 24.18 ? 544 HOH C O   1 
HETATM 9514 O  O   . HOH O 4 .   ? 23.883  5.757   -40.698 1.00 10.15 ? 545 HOH C O   1 
HETATM 9515 O  O   . HOH O 4 .   ? 42.741  16.764  -44.738 1.00 28.30 ? 546 HOH C O   1 
HETATM 9516 O  O   . HOH O 4 .   ? 39.234  -19.580 -46.389 1.00 29.26 ? 547 HOH C O   1 
HETATM 9517 O  O   . HOH O 4 .   ? 38.465  5.120   -45.254 1.00 13.30 ? 548 HOH C O   1 
HETATM 9518 O  O   . HOH O 4 .   ? 40.127  -11.770 -55.338 1.00 21.44 ? 549 HOH C O   1 
HETATM 9519 O  O   . HOH O 4 .   ? 59.135  -7.884  -34.493 1.00 28.21 ? 550 HOH C O   1 
HETATM 9520 O  O   . HOH O 4 .   ? 49.302  1.678   -12.822 1.00 30.23 ? 551 HOH C O   1 
HETATM 9521 O  O   . HOH O 4 .   ? 32.831  -14.570 -51.692 1.00 21.38 ? 552 HOH C O   1 
HETATM 9522 O  O   . HOH O 4 .   ? 28.982  3.712   -46.205 1.00 15.64 ? 553 HOH C O   1 
HETATM 9523 O  O   . HOH O 4 .   ? 28.817  -0.179  -14.430 1.00 25.70 ? 554 HOH C O   1 
HETATM 9524 O  O   . HOH O 4 .   ? 44.137  14.492  -33.971 1.00 42.16 ? 555 HOH C O   1 
HETATM 9525 O  O   . HOH O 4 .   ? 26.305  4.085   -49.937 1.00 32.78 ? 556 HOH C O   1 
HETATM 9526 O  O   . HOH O 4 .   ? 32.752  0.847   -50.995 1.00 30.93 ? 557 HOH C O   1 
HETATM 9527 O  O   . HOH O 4 .   ? 39.816  18.075  -40.939 1.00 21.36 ? 558 HOH C O   1 
HETATM 9528 O  O   . HOH O 4 .   ? 59.579  3.143   -20.742 1.00 27.25 ? 559 HOH C O   1 
HETATM 9529 O  O   . HOH O 4 .   ? 38.415  -19.008 -16.553 1.00 33.44 ? 560 HOH C O   1 
HETATM 9530 O  O   . HOH O 4 .   ? 26.622  9.761   -41.794 1.00 10.48 ? 561 HOH C O   1 
HETATM 9531 O  O   . HOH O 4 .   ? 46.887  10.960  -12.897 1.00 29.05 ? 562 HOH C O   1 
HETATM 9532 O  O   . HOH O 4 .   ? 40.781  -1.406  -48.721 1.00 43.56 ? 563 HOH C O   1 
HETATM 9533 O  O   . HOH O 4 .   ? 29.687  -12.566 -24.108 1.00 19.13 ? 564 HOH C O   1 
HETATM 9534 O  O   . HOH O 4 .   ? 22.734  -2.869  -49.853 1.00 34.90 ? 565 HOH C O   1 
HETATM 9535 O  O   . HOH O 4 .   ? 26.529  -4.973  -51.422 1.00 29.21 ? 566 HOH C O   1 
HETATM 9536 O  O   . HOH O 4 .   ? 42.736  -13.895 -48.817 1.00 25.42 ? 567 HOH C O   1 
HETATM 9537 O  O   . HOH O 4 .   ? 41.041  3.837   -6.881  1.00 25.34 ? 568 HOH C O   1 
HETATM 9538 O  O   . HOH O 4 .   ? 22.394  -0.303  -44.137 1.00 21.30 ? 569 HOH C O   1 
HETATM 9539 O  O   . HOH O 4 .   ? 24.094  -9.069  -29.083 1.00 26.06 ? 570 HOH C O   1 
HETATM 9540 O  O   . HOH O 4 .   ? 40.534  -14.102 -36.571 1.00 13.13 ? 571 HOH C O   1 
HETATM 9541 O  O   . HOH O 4 .   ? 26.531  3.408   -47.412 1.00 21.66 ? 572 HOH C O   1 
HETATM 9542 O  O   . HOH O 4 .   ? 52.011  4.901   -12.914 1.00 30.52 ? 573 HOH C O   1 
HETATM 9543 O  O   . HOH O 4 .   ? 28.458  6.893   -43.999 1.00 16.85 ? 574 HOH C O   1 
HETATM 9544 O  O   . HOH O 4 .   ? 31.741  12.826  -46.568 1.00 18.57 ? 575 HOH C O   1 
HETATM 9545 O  O   . HOH O 4 .   ? 53.642  5.724   -23.425 1.00 19.71 ? 576 HOH C O   1 
HETATM 9546 O  O   . HOH O 4 .   ? 23.201  -11.676 -44.636 1.00 25.29 ? 577 HOH C O   1 
HETATM 9547 O  O   . HOH O 4 .   ? 29.511  -13.913 -28.221 1.00 23.18 ? 578 HOH C O   1 
HETATM 9548 O  O   . HOH O 4 .   ? 38.846  16.658  -38.788 1.00 17.34 ? 579 HOH C O   1 
HETATM 9549 O  O   . HOH O 4 .   ? 39.019  13.708  -42.922 1.00 19.67 ? 580 HOH C O   1 
HETATM 9550 O  O   . HOH O 4 .   ? 44.369  14.160  -47.302 1.00 23.88 ? 581 HOH C O   1 
HETATM 9551 O  O   . HOH O 4 .   ? 44.324  -4.742  -9.821  1.00 42.56 ? 582 HOH C O   1 
HETATM 9552 O  O   . HOH O 4 .   ? 40.807  -16.554 -22.694 1.00 30.13 ? 583 HOH C O   1 
HETATM 9553 O  O   . HOH O 4 .   ? 47.008  -16.523 -35.880 1.00 25.19 ? 584 HOH C O   1 
HETATM 9554 O  O   . HOH O 4 .   ? 23.126  -9.000  -17.371 1.00 33.19 ? 585 HOH C O   1 
HETATM 9555 O  O   . HOH O 4 .   ? 52.991  -11.538 -37.025 1.00 32.87 ? 586 HOH C O   1 
HETATM 9556 O  O   . HOH O 4 .   ? 33.121  -14.734 -47.165 1.00 34.27 ? 587 HOH C O   1 
HETATM 9557 O  O   . HOH O 4 .   ? 49.998  12.014  -32.759 1.00 21.06 ? 588 HOH C O   1 
HETATM 9558 O  O   . HOH O 4 .   ? 36.259  -3.133  -11.436 1.00 32.54 ? 589 HOH C O   1 
HETATM 9559 O  O   . HOH O 4 .   ? 49.482  12.066  -48.539 1.00 27.23 ? 590 HOH C O   1 
HETATM 9560 O  O   . HOH O 4 .   ? 35.275  -0.470  -9.644  1.00 38.36 ? 591 HOH C O   1 
HETATM 9561 O  O   . HOH O 4 .   ? 29.748  -11.703 -26.701 1.00 15.94 ? 592 HOH C O   1 
HETATM 9562 O  O   . HOH O 4 .   ? 48.396  18.886  -40.739 1.00 30.75 ? 593 HOH C O   1 
HETATM 9563 O  O   . HOH O 4 .   ? 41.812  -3.680  -11.388 1.00 44.50 ? 594 HOH C O   1 
HETATM 9564 O  O   . HOH O 4 .   ? 26.969  6.322   -21.108 1.00 32.57 ? 595 HOH C O   1 
HETATM 9565 O  O   . HOH O 4 .   ? 53.214  -13.498 -30.451 1.00 27.73 ? 596 HOH C O   1 
HETATM 9566 O  O   . HOH O 4 .   ? 49.035  11.073  -24.126 1.00 31.57 ? 597 HOH C O   1 
HETATM 9567 O  O   . HOH O 4 .   ? 28.039  2.728   -52.214 1.00 32.32 ? 598 HOH C O   1 
HETATM 9568 O  O   . HOH O 4 .   ? 32.213  -1.867  -51.991 1.00 28.57 ? 599 HOH C O   1 
HETATM 9569 O  O   . HOH O 4 .   ? 27.802  -12.455 -30.145 1.00 23.98 ? 600 HOH C O   1 
HETATM 9570 O  O   . HOH O 4 .   ? 29.491  -12.251 -40.871 1.00 30.77 ? 601 HOH C O   1 
HETATM 9571 O  O   . HOH O 4 .   ? 55.918  6.542   -30.047 1.00 27.47 ? 602 HOH C O   1 
HETATM 9572 O  O   . HOH O 4 .   ? 46.850  13.867  -47.917 1.00 30.30 ? 603 HOH C O   1 
HETATM 9573 O  O   . HOH O 4 .   ? 47.316  -7.784  -47.045 1.00 40.98 ? 604 HOH C O   1 
HETATM 9574 O  O   . HOH O 4 .   ? 23.857  3.758   -51.342 1.00 40.58 ? 605 HOH C O   1 
HETATM 9575 O  O   . HOH O 4 .   ? 21.151  -1.110  -30.179 1.00 18.58 ? 606 HOH C O   1 
HETATM 9576 O  O   . HOH O 4 .   ? 53.957  6.787   -27.819 1.00 21.02 ? 607 HOH C O   1 
HETATM 9577 O  O   . HOH O 4 .   ? 24.698  5.271   -20.995 1.00 33.25 ? 608 HOH C O   1 
HETATM 9578 O  O   . HOH O 4 .   ? 45.672  -5.819  -48.059 1.00 33.46 ? 609 HOH C O   1 
HETATM 9579 O  O   . HOH O 4 .   ? 44.820  8.744   -30.825 1.00 34.63 ? 610 HOH C O   1 
HETATM 9580 O  O   . HOH O 4 .   ? 44.484  7.143   -8.947  1.00 27.83 ? 611 HOH C O   1 
HETATM 9581 O  O   . HOH O 4 .   ? 33.559  -18.221 -30.952 1.00 39.35 ? 612 HOH C O   1 
HETATM 9582 O  O   . HOH O 4 .   ? 39.670  -5.088  -49.495 1.00 22.29 ? 613 HOH C O   1 
HETATM 9583 O  O   . HOH O 4 .   ? 64.965  -5.998  -15.423 1.00 29.53 ? 614 HOH C O   1 
HETATM 9584 O  O   . HOH O 4 .   ? 56.025  12.263  -43.005 1.00 33.01 ? 615 HOH C O   1 
HETATM 9585 O  O   . HOH O 4 .   ? 41.202  4.532   -45.575 1.00 29.02 ? 616 HOH C O   1 
HETATM 9586 O  O   . HOH O 4 .   ? 54.949  -1.955  -44.986 1.00 30.01 ? 617 HOH C O   1 
HETATM 9587 O  O   . HOH O 4 .   ? 23.267  -3.818  -47.785 1.00 37.48 ? 618 HOH C O   1 
HETATM 9588 O  O   . HOH O 4 .   ? 42.984  -5.626  -54.513 1.00 20.75 ? 619 HOH C O   1 
HETATM 9589 O  O   . HOH O 4 .   ? 54.319  -9.321  -19.311 1.00 36.84 ? 620 HOH C O   1 
HETATM 9590 O  O   . HOH O 4 .   ? 41.769  14.958  -34.579 1.00 33.82 ? 621 HOH C O   1 
HETATM 9591 O  O   . HOH O 4 .   ? 34.534  21.955  -38.357 1.00 31.44 ? 622 HOH C O   1 
HETATM 9592 O  O   . HOH O 4 .   ? 54.187  4.834   -25.957 1.00 22.56 ? 623 HOH C O   1 
HETATM 9593 O  O   . HOH O 4 .   ? 28.251  15.337  -45.472 1.00 23.98 ? 624 HOH C O   1 
HETATM 9594 O  O   . HOH O 4 .   ? 21.320  -3.559  -32.212 1.00 28.57 ? 625 HOH C O   1 
HETATM 9595 O  O   . HOH O 4 .   ? 35.742  1.393   -50.289 1.00 28.35 ? 626 HOH C O   1 
HETATM 9596 O  O   . HOH O 4 .   ? 54.397  12.556  -48.502 1.00 38.37 ? 627 HOH C O   1 
HETATM 9597 O  O   . HOH O 4 .   ? 25.078  5.672   -45.927 1.00 31.66 ? 628 HOH C O   1 
HETATM 9598 O  O   . HOH O 4 .   ? 44.912  -15.984 -24.714 1.00 32.51 ? 629 HOH C O   1 
HETATM 9599 O  O   . HOH O 4 .   ? 22.859  -2.655  -34.181 1.00 23.93 ? 630 HOH C O   1 
HETATM 9600 O  O   . HOH O 4 .   ? 48.683  -15.783 -40.170 1.00 27.83 ? 631 HOH C O   1 
HETATM 9601 O  O   . HOH O 4 .   ? 22.061  -3.890  -38.226 1.00 23.88 ? 632 HOH C O   1 
HETATM 9602 O  O   . HOH O 4 .   ? 22.825  8.610   -27.930 1.00 17.12 ? 633 HOH C O   1 
HETATM 9603 O  O   . HOH O 4 .   ? 67.185  -4.342  -15.822 1.00 35.61 ? 634 HOH C O   1 
HETATM 9604 O  O   . HOH O 4 .   ? 37.984  16.702  -42.843 1.00 28.95 ? 635 HOH C O   1 
HETATM 9605 O  O   . HOH O 4 .   ? 28.481  27.353  -30.565 1.00 23.18 ? 636 HOH C O   1 
HETATM 9606 O  O   . HOH O 4 .   ? 38.459  -2.446  -48.882 1.00 30.31 ? 637 HOH C O   1 
HETATM 9607 O  O   . HOH O 4 .   ? 46.381  -15.345 -48.281 1.00 32.17 ? 638 HOH C O   1 
HETATM 9608 O  O   . HOH O 4 .   ? 40.713  6.655   -7.412  1.00 38.32 ? 639 HOH C O   1 
HETATM 9609 O  O   . HOH O 4 .   ? 45.342  -15.983 -45.884 1.00 26.63 ? 640 HOH C O   1 
HETATM 9610 O  O   . HOH O 4 .   ? 20.531  1.369   -45.609 1.00 29.92 ? 641 HOH C O   1 
HETATM 9611 O  O   . HOH O 4 .   ? 46.859  -13.200 -14.944 1.00 30.44 ? 642 HOH C O   1 
HETATM 9612 O  O   . HOH O 4 .   ? 38.537  -13.539 -56.161 1.00 26.88 ? 643 HOH C O   1 
HETATM 9613 O  O   . HOH O 4 .   ? 42.147  -10.613 -56.652 1.00 16.80 ? 644 HOH C O   1 
HETATM 9614 O  O   . HOH O 4 .   ? 35.095  23.695  -33.889 1.00 27.98 ? 645 HOH C O   1 
HETATM 9615 O  O   . HOH O 4 .   ? 51.302  15.580  -43.866 1.00 32.56 ? 646 HOH C O   1 
HETATM 9616 O  O   . HOH O 4 .   ? 40.687  16.807  -36.901 1.00 31.70 ? 647 HOH C O   1 
HETATM 9617 O  O   . HOH O 4 .   ? 50.440  -13.010 -16.544 1.00 35.56 ? 648 HOH C O   1 
HETATM 9618 O  O   . HOH O 4 .   ? 36.337  17.847  -38.464 1.00 19.67 ? 649 HOH C O   1 
HETATM 9619 O  O   . HOH O 4 .   ? 36.130  13.636  -45.925 1.00 28.15 ? 650 HOH C O   1 
HETATM 9620 O  O   . HOH O 4 .   ? 32.274  15.119  -45.488 1.00 33.63 ? 651 HOH C O   1 
HETATM 9621 O  O   . HOH O 4 .   ? 36.684  4.309   -50.125 1.00 25.40 ? 652 HOH C O   1 
HETATM 9622 O  O   . HOH O 4 .   ? 34.840  9.413   -47.939 1.00 27.20 ? 653 HOH C O   1 
HETATM 9623 O  O   . HOH O 4 .   ? 26.959  7.163   -47.425 1.00 30.51 ? 654 HOH C O   1 
HETATM 9624 O  O   . HOH O 4 .   ? 19.189  16.005  -21.078 1.00 31.34 ? 655 HOH C O   1 
HETATM 9625 O  O   . HOH O 4 .   ? 28.434  26.049  -28.092 1.00 38.43 ? 656 HOH C O   1 
HETATM 9626 O  O   . HOH O 4 .   ? 27.400  -13.732 -32.100 1.00 31.44 ? 657 HOH C O   1 
HETATM 9627 O  O   . HOH O 4 .   ? 37.786  18.332  -34.733 1.00 34.72 ? 658 HOH C O   1 
HETATM 9628 O  O   . HOH O 4 .   ? 30.166  6.025   -50.028 1.00 23.69 ? 659 HOH C O   1 
HETATM 9629 O  O   . HOH O 4 .   ? 25.938  -11.263 -17.295 1.00 34.24 ? 660 HOH C O   1 
HETATM 9630 O  O   . HOH O 4 .   ? 34.296  11.919  -47.665 1.00 22.61 ? 661 HOH C O   1 
HETATM 9631 O  O   . HOH O 4 .   ? 51.184  -12.684 -51.585 1.00 36.33 ? 662 HOH C O   1 
HETATM 9632 O  O   . HOH O 4 .   ? 30.606  13.928  -48.885 1.00 27.42 ? 663 HOH C O   1 
HETATM 9633 O  O   . HOH O 4 .   ? 48.567  -17.762 -42.233 1.00 38.43 ? 664 HOH C O   1 
HETATM 9634 O  O   . HOH O 4 .   ? 41.660  -18.239 -13.871 1.00 37.33 ? 665 HOH C O   1 
HETATM 9635 O  O   . HOH O 4 .   ? 46.805  -18.008 -44.584 1.00 30.81 ? 666 HOH C O   1 
HETATM 9636 O  O   . HOH O 4 .   ? 33.828  8.315   -50.224 1.00 29.37 ? 667 HOH C O   1 
HETATM 9637 O  O   . HOH O 4 .   ? 33.212  21.368  -42.946 1.00 27.62 ? 668 HOH C O   1 
HETATM 9638 O  O   . HOH O 4 .   ? 38.770  21.294  -38.119 1.00 35.25 ? 669 HOH C O   1 
HETATM 9639 O  O   . HOH P 4 .   ? -14.380 4.739   -37.082 1.00 20.37 ? 401 HOH D O   1 
HETATM 9640 O  O   . HOH P 4 .   ? 7.330   -16.733 -24.435 1.00 35.92 ? 402 HOH D O   1 
HETATM 9641 O  O   . HOH P 4 .   ? 16.996  8.518   -22.917 1.00 29.85 ? 403 HOH D O   1 
HETATM 9642 O  O   . HOH P 4 .   ? 1.699   8.083   -22.704 1.00 31.55 ? 404 HOH D O   1 
HETATM 9643 O  O   . HOH P 4 .   ? 23.067  1.591   -18.893 1.00 26.21 ? 405 HOH D O   1 
HETATM 9644 O  O   . HOH P 4 .   ? 3.935   9.703   -42.042 1.00 20.51 ? 406 HOH D O   1 
HETATM 9645 O  O   . HOH P 4 .   ? 14.406  2.663   -16.525 1.00 29.06 ? 407 HOH D O   1 
HETATM 9646 O  O   . HOH P 4 .   ? 4.306   4.817   -45.809 1.00 17.02 ? 408 HOH D O   1 
HETATM 9647 O  O   . HOH P 4 .   ? -21.044 0.525   -46.191 1.00 36.07 ? 409 HOH D O   1 
HETATM 9648 O  O   . HOH P 4 .   ? 4.581   23.286  -28.213 1.00 37.26 ? 410 HOH D O   1 
HETATM 9649 O  O   . HOH P 4 .   ? 10.609  19.795  -40.808 1.00 33.27 ? 411 HOH D O   1 
HETATM 9650 O  O   . HOH P 4 .   ? 17.441  -6.484  -56.384 1.00 30.45 ? 412 HOH D O   1 
HETATM 9651 O  O   . HOH P 4 .   ? -2.482  -14.929 -48.774 1.00 30.50 ? 413 HOH D O   1 
HETATM 9652 O  O   . HOH P 4 .   ? -5.338  -9.722  -34.665 1.00 24.70 ? 414 HOH D O   1 
HETATM 9653 O  O   . HOH P 4 .   ? -5.779  13.672  -37.154 1.00 21.88 ? 415 HOH D O   1 
HETATM 9654 O  O   . HOH P 4 .   ? 0.027   -10.307 -18.092 1.00 27.37 ? 416 HOH D O   1 
HETATM 9655 O  O   . HOH P 4 .   ? 5.931   -0.085  -57.867 1.00 24.99 ? 417 HOH D O   1 
HETATM 9656 O  O   . HOH P 4 .   ? -2.136  11.346  -58.076 1.00 30.37 ? 418 HOH D O   1 
HETATM 9657 O  O   . HOH P 4 .   ? -8.195  -6.269  -28.223 1.00 31.46 ? 419 HOH D O   1 
HETATM 9658 O  O   . HOH P 4 .   ? -18.743 5.642   -40.706 1.00 37.07 ? 420 HOH D O   1 
HETATM 9659 O  O   . HOH P 4 .   ? 14.420  -8.193  -52.595 1.00 25.12 ? 421 HOH D O   1 
HETATM 9660 O  O   . HOH P 4 .   ? -2.326  13.120  -39.306 1.00 34.86 ? 422 HOH D O   1 
HETATM 9661 O  O   . HOH P 4 .   ? -5.352  -5.547  -53.868 1.00 28.07 ? 423 HOH D O   1 
HETATM 9662 O  O   . HOH P 4 .   ? -9.875  15.068  -30.752 1.00 24.97 ? 424 HOH D O   1 
HETATM 9663 O  O   . HOH P 4 .   ? -2.745  -10.434 -39.391 1.00 21.24 ? 425 HOH D O   1 
HETATM 9664 O  O   . HOH P 4 .   ? 12.221  7.058   -39.445 1.00 8.01  ? 426 HOH D O   1 
HETATM 9665 O  O   . HOH P 4 .   ? 12.193  -6.798  -52.107 1.00 22.71 ? 427 HOH D O   1 
HETATM 9666 O  O   . HOH P 4 .   ? 20.477  -8.690  -38.522 1.00 34.81 ? 428 HOH D O   1 
HETATM 9667 O  O   . HOH P 4 .   ? -10.353 11.750  -26.091 1.00 15.81 ? 429 HOH D O   1 
HETATM 9668 O  O   . HOH P 4 .   ? -6.308  -8.873  -37.265 1.00 28.06 ? 430 HOH D O   1 
HETATM 9669 O  O   . HOH P 4 .   ? -1.332  -1.394  -22.612 1.00 29.36 ? 431 HOH D O   1 
HETATM 9670 O  O   . HOH P 4 .   ? -15.285 -2.269  -43.483 1.00 18.59 ? 432 HOH D O   1 
HETATM 9671 O  O   . HOH P 4 .   ? 1.295   9.223   -59.142 1.00 23.24 ? 433 HOH D O   1 
HETATM 9672 O  O   . HOH P 4 .   ? 20.138  8.171   -42.366 1.00 10.30 ? 434 HOH D O   1 
HETATM 9673 O  O   . HOH P 4 .   ? 11.038  13.378  -58.577 1.00 17.62 ? 435 HOH D O   1 
HETATM 9674 O  O   . HOH P 4 .   ? -5.989  4.329   -24.409 1.00 17.08 ? 436 HOH D O   1 
HETATM 9675 O  O   . HOH P 4 .   ? 1.341   -17.133 -26.940 1.00 31.64 ? 437 HOH D O   1 
HETATM 9676 O  O   . HOH P 4 .   ? -11.967 -4.547  -31.831 1.00 31.16 ? 438 HOH D O   1 
HETATM 9677 O  O   . HOH P 4 .   ? -11.534 11.278  -46.063 1.00 28.74 ? 439 HOH D O   1 
HETATM 9678 O  O   . HOH P 4 .   ? 18.647  5.327   -45.702 1.00 14.42 ? 440 HOH D O   1 
HETATM 9679 O  O   . HOH P 4 .   ? -5.331  19.713  -21.917 1.00 22.90 ? 441 HOH D O   1 
HETATM 9680 O  O   . HOH P 4 .   ? 20.641  -7.507  -29.819 1.00 16.06 ? 442 HOH D O   1 
HETATM 9681 O  O   . HOH P 4 .   ? 12.739  20.041  -29.278 1.00 28.55 ? 443 HOH D O   1 
HETATM 9682 O  O   . HOH P 4 .   ? 10.948  10.303  -61.698 1.00 28.97 ? 444 HOH D O   1 
HETATM 9683 O  O   . HOH P 4 .   ? 16.651  8.231   -51.390 1.00 24.62 ? 445 HOH D O   1 
HETATM 9684 O  O   . HOH P 4 .   ? -2.116  -4.121  -55.808 1.00 34.02 ? 446 HOH D O   1 
HETATM 9685 O  O   . HOH P 4 .   ? 18.704  -0.259  -20.519 1.00 36.37 ? 447 HOH D O   1 
HETATM 9686 O  O   . HOH P 4 .   ? -1.687  -8.943  -16.833 1.00 21.12 ? 448 HOH D O   1 
HETATM 9687 O  O   . HOH P 4 .   ? 4.460   -0.732  -14.547 1.00 29.43 ? 449 HOH D O   1 
HETATM 9688 O  O   . HOH P 4 .   ? -5.878  5.327   -56.191 1.00 28.49 ? 450 HOH D O   1 
HETATM 9689 O  O   . HOH P 4 .   ? 20.856  14.019  -47.830 1.00 14.88 ? 451 HOH D O   1 
HETATM 9690 O  O   . HOH P 4 .   ? 18.729  12.641  -58.304 1.00 30.58 ? 452 HOH D O   1 
HETATM 9691 O  O   . HOH P 4 .   ? 23.142  13.779  -28.635 1.00 22.04 ? 453 HOH D O   1 
HETATM 9692 O  O   . HOH P 4 .   ? 11.744  -10.973 -27.760 1.00 28.47 ? 454 HOH D O   1 
HETATM 9693 O  O   . HOH P 4 .   ? 0.992   -12.029 -14.013 1.00 28.52 ? 455 HOH D O   1 
HETATM 9694 O  O   . HOH P 4 .   ? 21.103  13.688  -35.622 1.00 6.82  ? 456 HOH D O   1 
HETATM 9695 O  O   . HOH P 4 .   ? -4.507  10.196  -57.274 1.00 31.82 ? 457 HOH D O   1 
HETATM 9696 O  O   . HOH P 4 .   ? -9.715  8.504   -20.743 1.00 22.11 ? 458 HOH D O   1 
HETATM 9697 O  O   . HOH P 4 .   ? 9.763   12.605  -22.602 1.00 26.66 ? 459 HOH D O   1 
HETATM 9698 O  O   . HOH P 4 .   ? -5.686  -9.878  -41.679 1.00 29.36 ? 460 HOH D O   1 
HETATM 9699 O  O   . HOH P 4 .   ? 11.127  17.918  -54.746 1.00 21.47 ? 461 HOH D O   1 
HETATM 9700 O  O   . HOH P 4 .   ? 0.350   19.416  -21.786 1.00 30.14 ? 462 HOH D O   1 
HETATM 9701 O  O   . HOH P 4 .   ? 20.528  -6.217  -38.309 1.00 33.59 ? 463 HOH D O   1 
HETATM 9702 O  O   . HOH P 4 .   ? 20.375  21.764  -32.886 1.00 25.18 ? 464 HOH D O   1 
HETATM 9703 O  O   . HOH P 4 .   ? 2.445   -15.285 -29.787 1.00 25.54 ? 465 HOH D O   1 
HETATM 9704 O  O   . HOH P 4 .   ? 21.355  18.597  -42.518 1.00 24.68 ? 466 HOH D O   1 
HETATM 9705 O  O   . HOH P 4 .   ? -5.337  -10.076 -45.144 1.00 31.66 ? 467 HOH D O   1 
HETATM 9706 O  O   . HOH P 4 .   ? -12.026 10.244  -23.365 1.00 26.38 ? 468 HOH D O   1 
HETATM 9707 O  O   . HOH P 4 .   ? 21.360  9.318   -25.773 1.00 31.36 ? 469 HOH D O   1 
HETATM 9708 O  O   . HOH P 4 .   ? 16.560  0.396   -37.481 1.00 6.89  ? 470 HOH D O   1 
HETATM 9709 O  O   . HOH P 4 .   ? 19.477  8.420   -29.248 1.00 10.57 ? 471 HOH D O   1 
HETATM 9710 O  O   . HOH P 4 .   ? -13.336 12.385  -32.488 1.00 32.35 ? 472 HOH D O   1 
HETATM 9711 O  O   . HOH P 4 .   ? 18.905  -0.663  -46.433 1.00 31.88 ? 473 HOH D O   1 
HETATM 9712 O  O   . HOH P 4 .   ? -12.083 -4.849  -44.306 1.00 22.31 ? 474 HOH D O   1 
HETATM 9713 O  O   . HOH P 4 .   ? -12.233 -3.717  -36.042 1.00 21.51 ? 475 HOH D O   1 
HETATM 9714 O  O   . HOH P 4 .   ? 19.132  -11.648 -21.289 1.00 31.10 ? 476 HOH D O   1 
HETATM 9715 O  O   . HOH P 4 .   ? 16.289  19.996  -57.081 1.00 30.50 ? 477 HOH D O   1 
HETATM 9716 O  O   . HOH P 4 .   ? -10.027 15.222  -20.981 1.00 20.13 ? 478 HOH D O   1 
HETATM 9717 O  O   . HOH P 4 .   ? 14.370  5.827   -60.085 1.00 32.98 ? 479 HOH D O   1 
HETATM 9718 O  O   . HOH P 4 .   ? 8.879   -10.704 -31.196 1.00 15.34 ? 480 HOH D O   1 
HETATM 9719 O  O   . HOH P 4 .   ? 17.408  -11.321 -27.353 1.00 20.55 ? 481 HOH D O   1 
HETATM 9720 O  O   . HOH P 4 .   ? -12.319 -7.897  -41.004 1.00 21.87 ? 482 HOH D O   1 
HETATM 9721 O  O   . HOH P 4 .   ? 5.331   -0.293  -17.885 1.00 31.32 ? 483 HOH D O   1 
HETATM 9722 O  O   . HOH P 4 .   ? 2.686   21.508  -31.786 1.00 35.31 ? 484 HOH D O   1 
HETATM 9723 O  O   . HOH P 4 .   ? 4.476   -6.907  -34.844 1.00 7.07  ? 485 HOH D O   1 
HETATM 9724 O  O   . HOH P 4 .   ? -5.454  -7.048  -27.859 1.00 18.25 ? 486 HOH D O   1 
HETATM 9725 O  O   . HOH P 4 .   ? -7.880  3.639   -21.638 1.00 35.05 ? 487 HOH D O   1 
HETATM 9726 O  O   . HOH P 4 .   ? 20.397  7.446   -35.716 1.00 11.40 ? 488 HOH D O   1 
HETATM 9727 O  O   . HOH P 4 .   ? 14.590  19.924  -42.705 1.00 30.72 ? 489 HOH D O   1 
HETATM 9728 O  O   . HOH P 4 .   ? -9.338  16.064  -28.495 1.00 27.10 ? 490 HOH D O   1 
HETATM 9729 O  O   . HOH P 4 .   ? -7.006  -6.828  -51.527 1.00 17.96 ? 491 HOH D O   1 
HETATM 9730 O  O   . HOH P 4 .   ? 4.662   16.127  -57.344 1.00 15.88 ? 492 HOH D O   1 
HETATM 9731 O  O   . HOH P 4 .   ? 1.228   2.613   -28.189 1.00 7.43  ? 493 HOH D O   1 
HETATM 9732 O  O   . HOH P 4 .   ? -7.021  -2.966  -53.296 1.00 26.26 ? 494 HOH D O   1 
HETATM 9733 O  O   . HOH P 4 .   ? -4.970  -13.805 -32.394 1.00 26.21 ? 495 HOH D O   1 
HETATM 9734 O  O   . HOH P 4 .   ? 14.279  17.679  -52.146 1.00 29.56 ? 496 HOH D O   1 
HETATM 9735 O  O   . HOH P 4 .   ? 0.821   -8.134  -18.986 1.00 15.70 ? 497 HOH D O   1 
HETATM 9736 O  O   . HOH P 4 .   ? -3.098  11.499  -46.112 1.00 23.56 ? 498 HOH D O   1 
HETATM 9737 O  O   . HOH P 4 .   ? 18.688  -0.201  -29.422 1.00 11.65 ? 499 HOH D O   1 
HETATM 9738 O  O   . HOH P 4 .   ? 17.193  18.925  -43.187 1.00 33.67 ? 500 HOH D O   1 
HETATM 9739 O  O   . HOH P 4 .   ? 6.325   17.677  -33.499 1.00 25.50 ? 501 HOH D O   1 
HETATM 9740 O  O   . HOH P 4 .   ? 9.548   7.878   -43.497 1.00 15.94 ? 502 HOH D O   1 
HETATM 9741 O  O   . HOH P 4 .   ? -3.357  -5.656  -26.894 1.00 16.83 ? 503 HOH D O   1 
HETATM 9742 O  O   . HOH P 4 .   ? -3.806  23.972  -31.115 1.00 33.95 ? 504 HOH D O   1 
HETATM 9743 O  O   . HOH P 4 .   ? 26.469  16.179  -43.625 1.00 16.37 ? 505 HOH D O   1 
HETATM 9744 O  O   . HOH P 4 .   ? 23.042  6.498   -38.232 1.00 7.47  ? 506 HOH D O   1 
HETATM 9745 O  O   . HOH P 4 .   ? -8.269  -0.170  -51.677 1.00 14.92 ? 507 HOH D O   1 
HETATM 9746 O  O   . HOH P 4 .   ? 13.618  22.630  -34.911 1.00 31.18 ? 508 HOH D O   1 
HETATM 9747 O  O   . HOH P 4 .   ? 12.019  -3.516  -47.280 1.00 8.51  ? 509 HOH D O   1 
HETATM 9748 O  O   . HOH P 4 .   ? 0.627   -12.682 -37.013 1.00 12.99 ? 510 HOH D O   1 
HETATM 9749 O  O   . HOH P 4 .   ? -9.811  -0.392  -49.411 1.00 13.62 ? 511 HOH D O   1 
HETATM 9750 O  O   . HOH P 4 .   ? 8.569   -16.374 -45.320 1.00 25.42 ? 512 HOH D O   1 
HETATM 9751 O  O   . HOH P 4 .   ? 9.419   17.400  -41.721 1.00 30.32 ? 513 HOH D O   1 
HETATM 9752 O  O   . HOH P 4 .   ? -8.199  13.608  -44.683 1.00 29.48 ? 514 HOH D O   1 
HETATM 9753 O  O   . HOH P 4 .   ? 19.100  11.813  -50.108 1.00 19.97 ? 515 HOH D O   1 
HETATM 9754 O  O   . HOH P 4 .   ? 9.180   -10.043 -58.137 1.00 19.22 ? 516 HOH D O   1 
HETATM 9755 O  O   . HOH P 4 .   ? 11.768  9.315   -47.039 1.00 15.81 ? 517 HOH D O   1 
HETATM 9756 O  O   . HOH P 4 .   ? 18.862  -3.239  -43.200 1.00 20.42 ? 518 HOH D O   1 
HETATM 9757 O  O   . HOH P 4 .   ? -12.181 5.608   -53.058 1.00 30.53 ? 519 HOH D O   1 
HETATM 9758 O  O   . HOH P 4 .   ? 19.949  11.148  -29.067 1.00 12.24 ? 520 HOH D O   1 
HETATM 9759 O  O   . HOH P 4 .   ? 6.725   -13.806 -51.001 1.00 8.24  ? 521 HOH D O   1 
HETATM 9760 O  O   . HOH P 4 .   ? -2.096  11.568  -20.355 1.00 19.35 ? 522 HOH D O   1 
HETATM 9761 O  O   . HOH P 4 .   ? 16.542  10.754  -50.227 1.00 19.36 ? 523 HOH D O   1 
HETATM 9762 O  O   . HOH P 4 .   ? -6.759  0.293   -55.994 1.00 21.48 ? 524 HOH D O   1 
HETATM 9763 O  O   . HOH P 4 .   ? 21.583  5.220   -34.252 1.00 6.52  ? 525 HOH D O   1 
HETATM 9764 O  O   . HOH P 4 .   ? 9.233   3.375   -52.980 1.00 10.18 ? 526 HOH D O   1 
HETATM 9765 O  O   . HOH P 4 .   ? 19.558  -3.946  -34.266 1.00 16.22 ? 527 HOH D O   1 
HETATM 9766 O  O   . HOH P 4 .   ? 10.978  13.427  -61.201 1.00 25.56 ? 528 HOH D O   1 
HETATM 9767 O  O   . HOH P 4 .   ? 19.555  19.028  -39.845 1.00 22.56 ? 529 HOH D O   1 
HETATM 9768 O  O   . HOH P 4 .   ? 19.170  4.989   -49.223 1.00 18.00 ? 530 HOH D O   1 
HETATM 9769 O  O   . HOH P 4 .   ? -7.794  11.965  -36.931 1.00 17.25 ? 531 HOH D O   1 
HETATM 9770 O  O   . HOH P 4 .   ? -12.696 -1.787  -34.120 1.00 13.41 ? 532 HOH D O   1 
HETATM 9771 O  O   . HOH P 4 .   ? 13.646  18.649  -32.444 1.00 8.99  ? 533 HOH D O   1 
HETATM 9772 O  O   . HOH P 4 .   ? 0.269   -11.792 -23.157 1.00 34.83 ? 534 HOH D O   1 
HETATM 9773 O  O   . HOH P 4 .   ? -11.286 11.932  -30.448 1.00 30.21 ? 535 HOH D O   1 
HETATM 9774 O  O   . HOH P 4 .   ? 18.214  7.373   -27.227 1.00 18.70 ? 536 HOH D O   1 
HETATM 9775 O  O   . HOH P 4 .   ? 11.994  4.611   -22.089 1.00 23.55 ? 537 HOH D O   1 
HETATM 9776 O  O   . HOH P 4 .   ? 3.990   19.372  -51.898 1.00 29.39 ? 538 HOH D O   1 
HETATM 9777 O  O   . HOH P 4 .   ? 19.139  16.795  -41.753 1.00 18.68 ? 539 HOH D O   1 
HETATM 9778 O  O   . HOH P 4 .   ? 6.107   -6.351  -57.527 1.00 15.40 ? 540 HOH D O   1 
HETATM 9779 O  O   . HOH P 4 .   ? -12.537 -4.382  -47.472 1.00 24.68 ? 541 HOH D O   1 
HETATM 9780 O  O   . HOH P 4 .   ? -2.271  -8.647  -41.747 1.00 13.12 ? 542 HOH D O   1 
HETATM 9781 O  O   . HOH P 4 .   ? 7.970   9.165   -24.424 1.00 15.84 ? 543 HOH D O   1 
HETATM 9782 O  O   . HOH P 4 .   ? -15.121 4.346   -31.803 1.00 27.94 ? 544 HOH D O   1 
HETATM 9783 O  O   . HOH P 4 .   ? 8.620   -9.077  -14.047 1.00 25.09 ? 545 HOH D O   1 
HETATM 9784 O  O   . HOH P 4 .   ? -2.064  -7.835  -22.639 1.00 15.73 ? 546 HOH D O   1 
HETATM 9785 O  O   . HOH P 4 .   ? 6.073   21.463  -25.831 1.00 20.44 ? 547 HOH D O   1 
HETATM 9786 O  O   . HOH P 4 .   ? 21.670  -9.712  -26.171 1.00 26.68 ? 548 HOH D O   1 
HETATM 9787 O  O   . HOH P 4 .   ? 21.567  6.750   -29.685 1.00 9.79  ? 549 HOH D O   1 
HETATM 9788 O  O   . HOH P 4 .   ? 7.675   -4.830  -14.534 1.00 27.47 ? 550 HOH D O   1 
HETATM 9789 O  O   . HOH P 4 .   ? 18.863  -13.115 -33.297 1.00 28.04 ? 551 HOH D O   1 
HETATM 9790 O  O   . HOH P 4 .   ? 0.038   0.676   -56.597 1.00 36.27 ? 552 HOH D O   1 
HETATM 9791 O  O   . HOH P 4 .   ? 2.602   -0.440  -56.864 1.00 27.59 ? 553 HOH D O   1 
HETATM 9792 O  O   . HOH P 4 .   ? -13.472 -1.232  -49.230 1.00 27.66 ? 554 HOH D O   1 
HETATM 9793 O  O   . HOH P 4 .   ? -2.223  -14.177 -26.185 1.00 29.32 ? 555 HOH D O   1 
HETATM 9794 O  O   . HOH P 4 .   ? 2.750   9.456   -24.877 1.00 14.01 ? 556 HOH D O   1 
HETATM 9795 O  O   . HOH P 4 .   ? -2.520  -0.568  -16.735 1.00 22.43 ? 557 HOH D O   1 
HETATM 9796 O  O   . HOH P 4 .   ? 16.526  16.182  -54.372 1.00 23.12 ? 558 HOH D O   1 
HETATM 9797 O  O   . HOH P 4 .   ? 24.022  18.505  -42.719 1.00 15.76 ? 559 HOH D O   1 
HETATM 9798 O  O   . HOH P 4 .   ? 23.669  10.480  -41.541 1.00 14.70 ? 560 HOH D O   1 
HETATM 9799 O  O   . HOH P 4 .   ? -10.430 -4.610  -29.557 1.00 21.83 ? 561 HOH D O   1 
HETATM 9800 O  O   . HOH P 4 .   ? 14.634  13.971  -27.276 1.00 11.46 ? 562 HOH D O   1 
HETATM 9801 O  O   . HOH P 4 .   ? 14.684  -12.006 -34.232 1.00 30.81 ? 563 HOH D O   1 
HETATM 9802 O  O   . HOH P 4 .   ? 9.755   -13.344 -55.724 1.00 38.25 ? 564 HOH D O   1 
HETATM 9803 O  O   . HOH P 4 .   ? -8.452  9.226   -55.567 1.00 21.54 ? 565 HOH D O   1 
HETATM 9804 O  O   . HOH P 4 .   ? 19.241  10.236  -35.774 1.00 8.24  ? 566 HOH D O   1 
HETATM 9805 O  O   . HOH P 4 .   ? -4.076  9.988   -17.495 1.00 15.85 ? 567 HOH D O   1 
HETATM 9806 O  O   . HOH P 4 .   ? -9.432  5.189   -55.514 1.00 41.25 ? 568 HOH D O   1 
HETATM 9807 O  O   . HOH P 4 .   ? -15.674 9.553   -47.342 1.00 19.75 ? 569 HOH D O   1 
HETATM 9808 O  O   . HOH P 4 .   ? 17.073  7.701   -55.736 1.00 24.82 ? 570 HOH D O   1 
HETATM 9809 O  O   . HOH P 4 .   ? 10.379  2.488   -21.385 1.00 15.84 ? 571 HOH D O   1 
HETATM 9810 O  O   . HOH P 4 .   ? 11.251  3.952   -55.155 1.00 14.85 ? 572 HOH D O   1 
HETATM 9811 O  O   . HOH P 4 .   ? 12.790  -9.645  -46.299 1.00 18.46 ? 573 HOH D O   1 
HETATM 9812 O  O   . HOH P 4 .   ? -2.970  17.563  -36.627 1.00 26.07 ? 574 HOH D O   1 
HETATM 9813 O  O   . HOH P 4 .   ? -15.328 4.487   -50.730 1.00 32.03 ? 575 HOH D O   1 
HETATM 9814 O  O   . HOH P 4 .   ? -17.852 -1.705  -44.912 1.00 29.06 ? 576 HOH D O   1 
HETATM 9815 O  O   . HOH P 4 .   ? -17.123 -4.281  -36.608 1.00 29.17 ? 577 HOH D O   1 
HETATM 9816 O  O   . HOH P 4 .   ? -6.579  -7.422  -32.807 1.00 36.80 ? 578 HOH D O   1 
HETATM 9817 O  O   . HOH P 4 .   ? 17.165  6.942   -48.863 1.00 17.87 ? 579 HOH D O   1 
HETATM 9818 O  O   . HOH P 4 .   ? 13.952  16.412  -26.423 1.00 17.45 ? 580 HOH D O   1 
HETATM 9819 O  O   . HOH P 4 .   ? 1.175   -4.808  -54.384 1.00 19.05 ? 581 HOH D O   1 
HETATM 9820 O  O   . HOH P 4 .   ? 19.242  -0.188  -36.920 1.00 11.77 ? 582 HOH D O   1 
HETATM 9821 O  O   . HOH P 4 .   ? 8.856   21.764  -29.630 1.00 15.90 ? 583 HOH D O   1 
HETATM 9822 O  O   . HOH P 4 .   ? 13.000  13.791  -48.596 1.00 22.08 ? 584 HOH D O   1 
HETATM 9823 O  O   . HOH P 4 .   ? -12.705 8.344   -55.275 1.00 26.64 ? 585 HOH D O   1 
HETATM 9824 O  O   . HOH P 4 .   ? -9.101  11.173  -45.073 1.00 16.92 ? 586 HOH D O   1 
HETATM 9825 O  O   . HOH P 4 .   ? 13.760  1.215   -55.692 1.00 23.81 ? 587 HOH D O   1 
HETATM 9826 O  O   . HOH P 4 .   ? 1.125   24.292  -29.946 1.00 32.26 ? 588 HOH D O   1 
HETATM 9827 O  O   . HOH P 4 .   ? -1.575  2.527   -58.305 1.00 43.66 ? 589 HOH D O   1 
HETATM 9828 O  O   . HOH P 4 .   ? 18.727  -7.449  -40.120 1.00 20.13 ? 590 HOH D O   1 
HETATM 9829 O  O   . HOH P 4 .   ? 3.436   -13.719 -39.720 1.00 26.19 ? 591 HOH D O   1 
HETATM 9830 O  O   . HOH P 4 .   ? 18.658  -4.201  -18.242 1.00 37.75 ? 592 HOH D O   1 
HETATM 9831 O  O   . HOH P 4 .   ? -14.193 9.389   -44.620 1.00 25.05 ? 593 HOH D O   1 
HETATM 9832 O  O   . HOH P 4 .   ? 11.779  21.811  -62.303 1.00 33.95 ? 594 HOH D O   1 
HETATM 9833 O  O   . HOH P 4 .   ? 13.700  7.735   -48.246 1.00 13.26 ? 595 HOH D O   1 
HETATM 9834 O  O   . HOH P 4 .   ? 14.037  -11.283 -21.112 1.00 30.97 ? 596 HOH D O   1 
HETATM 9835 O  O   . HOH P 4 .   ? 11.491  -10.865 -44.091 1.00 18.66 ? 597 HOH D O   1 
HETATM 9836 O  O   . HOH P 4 .   ? 12.366  1.970   -18.071 1.00 18.93 ? 598 HOH D O   1 
HETATM 9837 O  O   . HOH P 4 .   ? 15.578  9.978   -47.932 1.00 14.89 ? 599 HOH D O   1 
HETATM 9838 O  O   . HOH P 4 .   ? 20.823  -4.075  -28.636 1.00 21.32 ? 600 HOH D O   1 
HETATM 9839 O  O   . HOH P 4 .   ? 3.363   19.551  -20.031 1.00 32.35 ? 601 HOH D O   1 
HETATM 9840 O  O   . HOH P 4 .   ? 0.095   -12.130 -42.383 1.00 14.01 ? 602 HOH D O   1 
HETATM 9841 O  O   . HOH P 4 .   ? 1.393   -9.829  -31.306 1.00 8.80  ? 603 HOH D O   1 
HETATM 9842 O  O   . HOH P 4 .   ? -11.264 -7.173  -36.451 1.00 26.99 ? 604 HOH D O   1 
HETATM 9843 O  O   . HOH P 4 .   ? 9.557   20.164  -31.818 1.00 14.46 ? 605 HOH D O   1 
HETATM 9844 O  O   . HOH P 4 .   ? -16.175 4.439   -41.016 1.00 17.20 ? 606 HOH D O   1 
HETATM 9845 O  O   . HOH P 4 .   ? 20.099  -7.883  -56.217 1.00 37.52 ? 607 HOH D O   1 
HETATM 9846 O  O   . HOH P 4 .   ? 23.737  8.327   -45.327 1.00 25.48 ? 608 HOH D O   1 
HETATM 9847 O  O   . HOH P 4 .   ? 18.612  23.276  -34.089 1.00 21.33 ? 609 HOH D O   1 
HETATM 9848 O  O   . HOH P 4 .   ? -6.577  12.509  -40.009 1.00 20.30 ? 610 HOH D O   1 
HETATM 9849 O  O   . HOH P 4 .   ? 3.607   -15.435 -22.008 1.00 39.02 ? 611 HOH D O   1 
HETATM 9850 O  O   . HOH P 4 .   ? -4.758  -11.247 -28.315 1.00 16.58 ? 612 HOH D O   1 
HETATM 9851 O  O   . HOH P 4 .   ? 10.822  -10.375 -17.049 1.00 21.45 ? 613 HOH D O   1 
HETATM 9852 O  O   . HOH P 4 .   ? -8.531  16.348  -34.417 1.00 29.24 ? 614 HOH D O   1 
HETATM 9853 O  O   . HOH P 4 .   ? -5.491  -10.996 -30.933 1.00 28.12 ? 615 HOH D O   1 
HETATM 9854 O  O   . HOH P 4 .   ? 13.507  -3.400  -12.779 1.00 43.49 ? 616 HOH D O   1 
HETATM 9855 O  O   . HOH P 4 .   ? 5.860   18.595  -59.586 1.00 28.16 ? 617 HOH D O   1 
HETATM 9856 O  O   . HOH P 4 .   ? -20.321 5.715   -51.060 1.00 20.74 ? 618 HOH D O   1 
HETATM 9857 O  O   . HOH P 4 .   ? 21.814  0.665   -25.870 1.00 24.36 ? 619 HOH D O   1 
HETATM 9858 O  O   . HOH P 4 .   ? -10.579 19.501  -31.055 1.00 29.90 ? 620 HOH D O   1 
HETATM 9859 O  O   . HOH P 4 .   ? -15.092 -0.552  -35.527 1.00 16.96 ? 621 HOH D O   1 
HETATM 9860 O  O   . HOH P 4 .   ? 1.341   13.182  -40.561 1.00 33.93 ? 622 HOH D O   1 
HETATM 9861 O  O   . HOH P 4 .   ? 8.811   17.775  -27.363 1.00 20.02 ? 623 HOH D O   1 
HETATM 9862 O  O   . HOH P 4 .   ? -0.122  -12.693 -45.453 1.00 12.44 ? 624 HOH D O   1 
HETATM 9863 O  O   . HOH P 4 .   ? 16.577  24.311  -34.183 1.00 21.74 ? 625 HOH D O   1 
HETATM 9864 O  O   . HOH P 4 .   ? 15.994  15.328  -24.179 1.00 30.85 ? 626 HOH D O   1 
HETATM 9865 O  O   . HOH P 4 .   ? -17.476 5.594   -51.642 1.00 42.02 ? 627 HOH D O   1 
HETATM 9866 O  O   . HOH P 4 .   ? 8.936   -13.441 -29.957 1.00 28.10 ? 628 HOH D O   1 
HETATM 9867 O  O   . HOH P 4 .   ? -11.378 12.886  -38.076 1.00 29.21 ? 629 HOH D O   1 
HETATM 9868 O  O   . HOH P 4 .   ? -2.551  13.957  -56.641 1.00 23.79 ? 630 HOH D O   1 
HETATM 9869 O  O   . HOH P 4 .   ? 24.907  10.003  -44.084 1.00 34.34 ? 631 HOH D O   1 
HETATM 9870 O  O   . HOH P 4 .   ? 2.791   1.577   -20.307 1.00 35.08 ? 632 HOH D O   1 
HETATM 9871 O  O   . HOH P 4 .   ? -17.435 8.272   -50.304 1.00 34.31 ? 633 HOH D O   1 
HETATM 9872 O  O   . HOH P 4 .   ? -19.807 -0.579  -44.593 1.00 35.21 ? 634 HOH D O   1 
HETATM 9873 O  O   . HOH P 4 .   ? -16.125 3.216   -38.396 1.00 22.52 ? 635 HOH D O   1 
HETATM 9874 O  O   . HOH P 4 .   ? -5.875  15.712  -35.519 1.00 19.16 ? 636 HOH D O   1 
HETATM 9875 O  O   . HOH P 4 .   ? 11.042  18.939  -44.295 1.00 38.16 ? 637 HOH D O   1 
HETATM 9876 O  O   . HOH P 4 .   ? 2.028   15.395  -40.270 1.00 35.90 ? 638 HOH D O   1 
HETATM 9877 O  O   . HOH P 4 .   ? -0.388  3.916   -20.435 1.00 32.47 ? 639 HOH D O   1 
HETATM 9878 O  O   . HOH P 4 .   ? -2.399  -14.642 -39.450 1.00 25.49 ? 640 HOH D O   1 
HETATM 9879 O  O   . HOH P 4 .   ? 21.036  -0.597  -41.702 1.00 29.24 ? 641 HOH D O   1 
HETATM 9880 O  O   . HOH P 4 .   ? 13.188  11.545  -46.664 1.00 25.07 ? 642 HOH D O   1 
HETATM 9881 O  O   . HOH P 4 .   ? -13.807 12.327  -49.486 1.00 36.59 ? 643 HOH D O   1 
HETATM 9882 O  O   . HOH P 4 .   ? 11.682  -10.234 -42.071 1.00 23.20 ? 644 HOH D O   1 
HETATM 9883 O  O   . HOH P 4 .   ? 22.732  -1.528  -39.955 1.00 22.80 ? 645 HOH D O   1 
HETATM 9884 O  O   . HOH P 4 .   ? 10.248  -10.596 -20.802 1.00 31.91 ? 646 HOH D O   1 
HETATM 9885 O  O   . HOH P 4 .   ? 22.789  -4.956  -26.736 1.00 35.78 ? 647 HOH D O   1 
HETATM 9886 O  O   . HOH P 4 .   ? -9.634  0.348   -54.487 1.00 31.92 ? 648 HOH D O   1 
HETATM 9887 O  O   . HOH P 4 .   ? 21.719  -5.324  -57.678 1.00 38.96 ? 649 HOH D O   1 
HETATM 9888 O  O   . HOH P 4 .   ? 14.054  -10.663 -27.537 1.00 34.98 ? 650 HOH D O   1 
HETATM 9889 O  O   . HOH P 4 .   ? 16.489  1.665   -55.504 1.00 32.88 ? 651 HOH D O   1 
HETATM 9890 O  O   . HOH P 4 .   ? -8.171  19.435  -26.187 1.00 32.19 ? 652 HOH D O   1 
HETATM 9891 O  O   . HOH P 4 .   ? -16.976 1.701   -36.929 1.00 30.51 ? 653 HOH D O   1 
HETATM 9892 O  O   . HOH P 4 .   ? 5.330   9.592   -23.811 1.00 20.93 ? 654 HOH D O   1 
HETATM 9893 O  O   . HOH P 4 .   ? -9.557  10.389  -42.117 1.00 22.51 ? 655 HOH D O   1 
HETATM 9894 O  O   . HOH P 4 .   ? 0.969   -14.666 -41.611 1.00 31.84 ? 656 HOH D O   1 
HETATM 9895 O  O   . HOH P 4 .   ? 11.164  -13.970 -19.362 1.00 38.74 ? 657 HOH D O   1 
HETATM 9896 O  O   . HOH P 4 .   ? -2.843  -12.184 -45.181 1.00 21.18 ? 658 HOH D O   1 
HETATM 9897 O  O   . HOH P 4 .   ? -8.253  12.889  -41.182 1.00 27.84 ? 659 HOH D O   1 
HETATM 9898 O  O   . HOH P 4 .   ? 20.374  -2.473  -36.511 1.00 28.61 ? 660 HOH D O   1 
HETATM 9899 O  O   . HOH P 4 .   ? -16.016 10.069  -54.777 1.00 29.43 ? 661 HOH D O   1 
HETATM 9900 O  O   . HOH P 4 .   ? 8.683   9.880   -21.902 1.00 28.35 ? 662 HOH D O   1 
HETATM 9901 O  O   . HOH P 4 .   ? -15.046 6.829   -40.743 1.00 26.47 ? 663 HOH D O   1 
HETATM 9902 O  O   . HOH P 4 .   ? 14.523  -11.253 -47.680 1.00 29.21 ? 664 HOH D O   1 
HETATM 9903 O  O   . HOH P 4 .   ? 7.404   -4.187  -58.479 1.00 28.86 ? 665 HOH D O   1 
HETATM 9904 O  O   . HOH P 4 .   ? 2.035   -7.227  -55.640 1.00 26.21 ? 666 HOH D O   1 
HETATM 9905 O  O   . HOH P 4 .   ? -22.119 6.287   -49.145 1.00 23.09 ? 667 HOH D O   1 
HETATM 9906 O  O   . HOH P 4 .   ? 12.248  -12.404 -56.748 1.00 19.76 ? 668 HOH D O   1 
HETATM 9907 O  O   . HOH P 4 .   ? 27.860  13.203  -47.097 1.00 25.09 ? 669 HOH D O   1 
HETATM 9908 O  O   . HOH P 4 .   ? -14.533 -5.170  -36.214 1.00 30.79 ? 670 HOH D O   1 
HETATM 9909 O  O   . HOH P 4 .   ? 22.706  7.773   -42.575 1.00 21.84 ? 671 HOH D O   1 
HETATM 9910 O  O   . HOH P 4 .   ? -6.474  7.834   -57.413 1.00 23.98 ? 672 HOH D O   1 
HETATM 9911 O  O   . HOH P 4 .   ? -1.792  -11.277 -41.036 1.00 25.21 ? 673 HOH D O   1 
HETATM 9912 O  O   . HOH P 4 .   ? 5.382   -2.279  -59.018 1.00 25.75 ? 674 HOH D O   1 
HETATM 9913 O  O   . HOH P 4 .   ? 20.788  4.033   -46.842 1.00 20.49 ? 675 HOH D O   1 
HETATM 9914 O  O   . HOH P 4 .   ? 3.422   -6.512  -58.012 1.00 21.75 ? 676 HOH D O   1 
HETATM 9915 O  O   . HOH P 4 .   ? -1.240  -12.375 -39.077 1.00 25.43 ? 677 HOH D O   1 
HETATM 9916 O  O   . HOH P 4 .   ? 3.905   17.812  -49.584 1.00 34.83 ? 678 HOH D O   1 
HETATM 9917 O  O   . HOH P 4 .   ? 5.978   18.748  -35.841 1.00 27.71 ? 679 HOH D O   1 
HETATM 9918 O  O   . HOH P 4 .   ? 22.413  -7.554  -27.658 1.00 21.74 ? 680 HOH D O   1 
HETATM 9919 O  O   . HOH P 4 .   ? -6.602  -9.354  -26.888 1.00 29.59 ? 681 HOH D O   1 
HETATM 9920 O  O   . HOH P 4 .   ? -2.867  -9.800  -21.191 1.00 22.59 ? 682 HOH D O   1 
HETATM 9921 O  O   . HOH P 4 .   ? -14.721 9.223   -42.117 1.00 27.68 ? 683 HOH D O   1 
HETATM 9922 O  O   . HOH P 4 .   ? -3.779  -11.748 -42.465 1.00 25.59 ? 684 HOH D O   1 
HETATM 9923 O  O   . HOH P 4 .   ? 10.210  -11.792 -33.249 1.00 29.38 ? 685 HOH D O   1 
HETATM 9924 O  O   . HOH P 4 .   ? 16.275  -13.912 -26.644 1.00 34.93 ? 686 HOH D O   1 
HETATM 9925 O  O   . HOH P 4 .   ? 5.942   2.236   -20.273 1.00 39.88 ? 687 HOH D O   1 
HETATM 9926 O  O   . HOH P 4 .   ? -1.143  -15.356 -44.732 1.00 28.53 ? 688 HOH D O   1 
HETATM 9927 O  O   . HOH P 4 .   ? -11.404 -2.409  -49.785 1.00 23.93 ? 689 HOH D O   1 
HETATM 9928 O  O   . HOH P 4 .   ? -10.845 18.472  -28.741 1.00 30.32 ? 690 HOH D O   1 
HETATM 9929 O  O   . HOH P 4 .   ? -3.797  -8.783  -18.641 1.00 26.76 ? 691 HOH D O   1 
HETATM 9930 O  O   . HOH P 4 .   ? -8.176  -10.647 -41.991 1.00 34.72 ? 692 HOH D O   1 
HETATM 9931 O  O   . HOH P 4 .   ? -4.483  -14.512 -46.206 1.00 35.21 ? 693 HOH D O   1 
HETATM 9932 O  O   . HOH P 4 .   ? 5.758   -15.530 -36.701 1.00 34.74 ? 694 HOH D O   1 
HETATM 9933 O  O   . HOH P 4 .   ? 19.846  -5.709  -41.929 1.00 19.38 ? 695 HOH D O   1 
HETATM 9934 O  O   . HOH P 4 .   ? -7.728  -6.596  -18.361 1.00 30.19 ? 696 HOH D O   1 
HETATM 9935 O  O   . HOH P 4 .   ? 9.949   8.592   -19.522 1.00 26.54 ? 697 HOH D O   1 
HETATM 9936 O  O   . HOH P 4 .   ? -14.550 -4.180  -45.601 1.00 36.45 ? 698 HOH D O   1 
HETATM 9937 O  O   . HOH P 4 .   ? 12.536  12.992  -22.565 1.00 33.90 ? 699 HOH D O   1 
HETATM 9938 O  O   . HOH P 4 .   ? -6.449  -9.097  -52.898 1.00 24.18 ? 700 HOH D O   1 
HETATM 9939 O  O   . HOH P 4 .   ? 10.761  4.042   -19.347 1.00 24.64 ? 701 HOH D O   1 
HETATM 9940 O  O   . HOH P 4 .   ? -12.235 11.010  -42.075 1.00 32.10 ? 702 HOH D O   1 
HETATM 9941 O  O   . HOH P 4 .   ? 27.824  13.221  -49.656 1.00 28.62 ? 703 HOH D O   1 
HETATM 9942 O  O   . HOH P 4 .   ? 12.169  20.951  -32.517 1.00 17.20 ? 704 HOH D O   1 
HETATM 9943 O  O   . HOH P 4 .   ? 15.266  26.417  -35.261 1.00 28.44 ? 705 HOH D O   1 
HETATM 9944 O  O   . HOH P 4 .   ? 7.652   20.877  -33.754 1.00 33.90 ? 706 HOH D O   1 
HETATM 9945 O  O   . HOH P 4 .   ? -6.727  -12.370 -45.836 1.00 37.00 ? 707 HOH D O   1 
HETATM 9946 O  O   . HOH P 4 .   ? -4.610  -13.534 -27.392 1.00 36.76 ? 708 HOH D O   1 
HETATM 9947 O  O   . HOH P 4 .   ? 7.143   -8.265  -59.106 1.00 20.99 ? 709 HOH D O   1 
HETATM 9948 O  O   . HOH P 4 .   ? 14.875  24.642  -31.984 1.00 24.06 ? 710 HOH D O   1 
HETATM 9949 O  O   . HOH P 4 .   ? 11.875  6.283   -19.742 1.00 22.69 ? 711 HOH D O   1 
HETATM 9950 O  O   . HOH P 4 .   ? 2.600   -3.467  -58.435 1.00 32.33 ? 712 HOH D O   1 
HETATM 9951 O  O   . HOH P 4 .   ? 13.668  7.328   -18.256 1.00 34.41 ? 713 HOH D O   1 
HETATM 9952 O  O   . HOH P 4 .   ? 9.253   21.046  -36.416 1.00 37.40 ? 714 HOH D O   1 
HETATM 9953 O  O   . HOH P 4 .   ? -6.504  -9.088  -18.390 1.00 23.29 ? 715 HOH D O   1 
HETATM 9954 O  O   . HOH P 4 .   ? -4.179  -14.094 -41.689 1.00 26.57 ? 716 HOH D O   1 
# 
